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Introduction: Organophosphorus poisoning (OPP) is one of the common medical emergencies among rural population in India due to suicide attempts. The purpose of this study was to investigate the relationship between the initial emergency laboratory parameters (electrolytes, liver function test, random blood glucose (RBS), renal function test, Hb, RBC and WBC) and severity of organophosphate poisoning based on Bardin’s Classification and type of OP compound consumed in patients admitted to emergency department with OPP. Materials and Methods: A retrospective observational study was done in OPP patients admitted to emergency medicine department. Based on Bardin’s classification all OPP cases were classified into 3 Grades of severity of poisoning.1-3 Hematological and biochemical parameters were compared based on this severity of poisoning. Results: With random sampling of 45 patients, 19 male and 26 female patients aged between 25-35 years, admitted with OPP were included in the study. The severity of poisoning was worst in females. The pseudocholinesterase, potassium and creatinine levels were significantly low in patients of grade 3 than grade 1 and grade 2 (p Conclusion: Emergency laboratory parameters in acute oraganophosphorus poisoning reflect the need for basic diagnostic facility in rural area. Laboratory parameters can also serve as possible predictive markers for severe outcomes and prognosis in OP poisoning. The knowledge of type of OP compound consumed can predict the severity of OP intoxication and need for emergency intervention. Keywords: Oragano phosphorous poisoning, Biochemical parameters.

Introduction: A triad of clinical evaluation, electrocardiography and biomarkers of acute cardio necrosis are basis for diagnosing acute coronary syndrome (ACS). Evaluation of ACS by electrocardiography can be inconclusive in patients on maintenance hemodialysis; thereby making cardiac biomarkers better indicators. Hemodialysis is known to alter troponin I values with studies suggesting high false positives but not for the values of CKMB mass. Aim: The aim of the study was to estimate the levels of cardiac CKMB-mass in patients with stage IV/stage V renal failure on maintenance hemodialysis (MHD) with no evidence of cardiac disease, and to correlate these values with manufactures guidelines for healthy individuals (cut off of Materials and Methods: The study was conducted on 23 patients between age group 20 to 70 years, diagnosed with stage IV or V Chronic Kidney disease (CKD) (confirmed biochemically and ultrasonographically). These patients were undergoing regular biweekly regime of maintenance hemodialysis for more than 3 months at dialysis unit PESIMSR, Kuppam. CKMB mass levels were measured in these patients. Results and Conclusion: The kidney function tests and electrolyte values were deranged in patients with CKD, however as the patients were on calcium supplementation, mineral levels were within normal range. Liver function tests of these patients were found to be normal. The hemoglobin and RBC levels were lower due to CKD associated anemia. CKMB-mass levels of these patients were done in Biomerieux Vidas analyzer using Enzyme linked fluorescent assay (ELFA) method. The values were within manufacturer’s cutoff range of 5ng/ml with mean value of 3.0±1.69 ng/ml. The patients were followed up either until death or for 24 months for any cardiac related events and follow up rate was 99%. The overall survival rates of the patients were found to be 77% and none of the patients were found to have developed cardiac related events and specifically myocardia

BACKGROUND Subclinical thyroid disorders with altered Thyroid Stimulating Hormone (TSH) level, yet normal circulating levels of free thyroid hormones (FT4) include subclinical hypothyroidism and subclinical hyperthyroidism. The prevalence of subclinical thyroid disorders is found to be increasing in our country and subclinical hypothyroidism is known to be linked with hypercholesterolemia. Hence, we intend to find the prevalence of subclinical thyroid diseases and its association with lipid profile. MATERIALS AND METHODS This study was done on 253 female medical students of PES institute of medical Sciences and research who were willing to participate in the study. Free T4 (FT4) and Thyroid Stimulating Hormone (TSH) levels were estimated by Enzyme Linked Immuno-Fluorescent Assay (ELFA). Lipid Profile of the subjects including total cholesterol, serum triglyceride, HDL, LDL, VLDL was estimated using VITROS instrument. Based on the levels of TSH and FT4 the students were categorized as euthyroid, subclinical hypothyroid and subclinical hyperthyroid. RESULTS The prevalence of subclinical hypothyroidism and subclinical hyperthyroidism was found to be 8.3% and 1.58% respectively among the study population. A statistically significant decrease in FT4 levels as the TSH levels increased was seen. As the TSH value increased, HDL levels significantly decreased, and the LDL levels were found to be increased significantly. CONCLUSION Prevalence of subclinical hypothyroidism is found to be high in our study. The students with subclinical hypothyroidism were found to have significantly increased levels of LDL and decreased levels of HDL, which is an important risk factor for atherosclerosis, hypertension and coronary heart disease. Hence early detection of subclinical thyroid disorders would help us prevent the individual from developing the overt disease and its complications.

BACKGROUND Thyroid dysfunction is very common in India. Among the thyroid disorders, it has been found that there is an increase in prevalence of Subclinical Hypothyroidism rather than Hypothyroidism in India. Although it has been three decades since universal salt iodization program was introduced in our country and a transition from iodine deficient to iodine sufficient state was considered to be attained in our country, the prevalence of thyroid disorders is still found to be increasing. Therefore, we aim to find the prevalence of various thyroid dysfunctions among the young adults so that early intervention can prevent the complications associated with thyroid disorders. MATERIALS AND METHODS This study was done on 100 first year medical students of PES institute of medical Sciences and research who were willing to participate in the study. Ethical clearance was taken from the institutional ethical committee. Written consent from the subjects was taken and 5 ml venous blood sample was collected from each subject after an overnight fasting. Free T4 (FT4) and Thyroid stimulating hormone (TSH) levels were estimated by Enzyme linked immuno-fluorescent assay (ELFA) using Biomeriex VIDAS instrument. Based on the levels of TSH and FT4 the students were categorized as Euthyroid, Hypothyroid, Subclinical Hypothyroid, Hyperthyroid or Subclinical Hyperthyroid. RESULTS Among 100 students involved in our study, 22 were males and 78 were females. 89% of the participants were found to be euthyroid. Prevalence of Subclinical Hypothyroidism was 8% and Prevalence of Subclinical Hyperthyroidism was 3%. It was found that all the cases of Subclinical Hypothyroidism and Subclinical Hyperthyroidism were females. CONCLUSION Early detection of thyroid disorders especially Subclinical Hypothyroidism and Subclinical Hyperthyroidism can prevent the complications associated with it.