1. Renal involvement and metabolic alterations in adults patients affected by cystic fibrosis
- Author
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Enea Bonci, Paolo Palange, Manuel Murciano, Camilla Celani, Paolo Giangreco Marotta, Anna Paola Mitterhofer, Sandro Mazzaferro, Francesco Pelligra, Silvia Lai, Giuseppe Cimino, and Patrizia Troiani
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Renal function ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Kidney ,Cystic fibrosis ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Forced Expiratory Volume ,Chronic kidney disease ,medicine ,Lung transplantation ,Humans ,030212 general & internal medicine ,Endothelial dysfunction ,education ,Triglycerides ,education.field_of_study ,Lung ,business.industry ,Incidence (epidemiology) ,Research ,lcsh:R ,General Medicine ,medicine.disease ,Cardiovascular disease ,medicine.anatomical_structure ,Female ,business ,Kidney disease ,Glomerular Filtration Rate ,Lung Transplantation - Abstract
Background Cystic fibrosis (CF) is one of the most frequent genetic diseases and the median survival of these patients has improved in the last few decades, therefore it becomes necessary to evaluate the long-term complications as renal and cardiovascular risk factors. Aim of the study To evaluate the incidence, the manifestations of renal disease and the possible association with metabolic and endothelial dysfunction markers in the CF population. Materials and methods We performed a cross-sectional, observational study on 226 CF patients. Clinical and laboratory instrumental parameters (metabolic, inflammatory and endothelial dysfunction markers) were evaluated. Results We showed 65 patients with chronic kidney disease (CKD) and 158 patients with a reduced value of forced expiratory volume in 1 s (FEV1), of which 58 patients with a severe reduction of FEV1. Moreover 28 patients had undergone lung transplantation and them had a significant lower estimated Glomerular Filtration Rate (eGFR) with respect to the non-transplanted patients (p Conclusions Our study showed a high prevalence of CKD in CF patients. Moreover we showed an increase of endothelial dysfunction and metabolic indexes in patients with reduced renal function, as SUA, serum triglycerides and LDL, suggesting the need for an early and complete screening of the main metabolic indexes to reduce cardiovascular risk and progression of renal damage, in particular in patients with lung transplant.
- Published
- 2019