1. Ivabradine Versus Amiodarone in the Management of Postoperative Junctional Ectopic Tachycardia
- Author
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Milind Padmakar Hote, Rajnish Juneja, Sarvesh Pal Singh, Sachin Talwar, Sivasubramanian Ramakrishnan, Balaji Arvind, Shyam S. Kothari, Saurabh Gupta, Velayoudam Devagourou, Palleti Rajashekar, Anita Saxena, Manoj Kumar Sahu, and Ujjwal K. Chowdhury
- Subjects
medicine.medical_specialty ,business.industry ,030204 cardiovascular system & hematology ,Amiodarone ,medicine.disease ,Cardiac surgery ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Interquartile range ,Internal medicine ,Junctional ectopic tachycardia ,medicine ,Clinical endpoint ,Cardiology ,Sinus rhythm ,030212 general & internal medicine ,business ,Ivabradine ,medicine.drug - Abstract
Objectives This study sought to compare the efficacy of ivabradine and amiodarone in the management of postoperative junctional ectopic tachycardia (JET) after cardiac surgery in children. Background JET is a serious arrhythmia occurring in children after cardiac surgery and requires aggressive management. Amiodarone has been conventionally used in its treatment. Recent studies have reported the utility of ivabradine in this regard. Methods In this open-label randomized controlled trial, 94 children (age ≤18 years) who developed postoperative JET were allocated to receive either amiodarone or ivabradine. The primary endpoint was restoration of normal sinus rhythm. Results Sinus rhythm was achieved in 43 out of the 46 patients (93.5%) in the amiodarone group and 46 out of the 48 patients (95.8%) in the ivabradine group (mean difference of treatment effect: 2.3%; 95% confidence interval: −6.7% to 11.5%). The median (interquartile range) time taken to achieve sinus rhythm conversion was similar in both the groups: 21.5 (17–30.2) hours versus 22 (13.4–38.5) hours (p = 0.36)]. The time taken to rate control of JET was significantly less in the amiodarone group: median 7.0 (5.5–9.5) hours versus 8.0 (5.8–10.8) hours (p = 0.02)]. No drug-related adverse events were observed in the ivabradine group. Conclusions Oral ivabradine is not inferior to intravenous amiodarone in converting postoperative JET to sinus rhythm. There was no difference in time taken to sinus rhythm conversion between the groups, although the rate control was earlier in patients who received amiodarone. Monotherapy with ivabradine may be considered as an alternative to amiodarone in the management of postoperative JET. (Comparison of Two Drugs, Ivabradine and Amiodarone, in the Management of Junctional Ectopic Tachycardia, an Abnormality in Cardiac Rhythm in Patients Under 18 years Who Undergo Cardiac Surgery: CTRI/2018/08/015182 )
- Published
- 2021