1. Neurodevelopmental outcomes in mild and moderate isolated ventriculomegaly originating in utero
- Author
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Baihua Jing, Faliang Zhou, Lili Liu, Hongyan Liu, Xinlin Hou, Junya Chen, and Guoyu Sun
- Subjects
Fetus ,medicine.medical_specialty ,Hyperplasia ,030219 obstetrics & reproductive medicine ,urogenital system ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Nervous System Malformations ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Neurodevelopmental Disorders ,In utero ,030225 pediatrics ,embryonic structures ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,business ,Hydrocephalus ,Ventriculomegaly - Abstract
To determine the differences in outcomes between mild and moderate isolated ventriculomegaly (IVM).We conducted a prospective cohort study on 94 fetuses with IVM and evaluated the neurodevelopmental outcomes at 12 months of age using the ASQ-3 and BSID-I neurodevelopmental assessment tools. Progression of VM was defined as an increase in the width of the ventricular by at least 3 mm during sequential ultrasound monitoring. The population was divided into two groups according to ventricular width: mild (10-12 mm) and moderate (12.1-15 mm), which were further evaluated for VM progression in utero separately.Neurodevelopmental assessments at 12 months were the main form of evaluations. Neurodevelopmental impairment (NDI) was defined as a mental development index (MDI) or psychomotor development index (PDI)85. There were no significant differences in NDI values between the mild and moderate groups (There were likely no differences in neurodevelopmental outcomes between mild and moderate IVM. In fetuses with mild to moderate VM, intrauterine progression may be a poor prognostic factor for neurodevelopmental outcomes.
- Published
- 2021
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