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Infections of the ears, nose and thsoat are caused by a variety of pathogens at different sites and under various pathological conditions. Therefore, treatment with one antibiotic agent is sometimes not effective. In this study we evaluated the clinical and bacteriological results of combination therapy with aztreonam (AZT) and fosfomycin (FOM) in 4g patients with an acute exacerbation of chronic otitis media, chronic sinusitis or chronic tonsillitis.The clinical effectiveness was 80.4%. Of the 41 strains of bacteria isolated, disappeared, 6 decreased and 9 were unchanged after the treatmedt of AZT and FOM. No side effects were observed.

In recent years, the number of adults with acute deterioration of chronic otorhinolaryngological infections has been increasing.Problems that we encounter in the treatment of chronic otorhinolaryngological infections include an increase of drug-resistant bacteria and unsatisfactory penetration of drugs into the tissues. The authors recently used Tarivide (ofloxacin), a new drug of the quinolone family, to treat 20 patients with acute deterioration of chronic otorhinolaryngological diseases (tonsillitis, nasosinusitis and tympanitis). The drug proved to be clinically effective in 95.0% and bacteriologically effective in 88.2% of the 20 patients. In 6 patients who were treated with this drug preoperatively, the blood and tissue concentrations of the drug were high.These results indicate that ofloxacin can be useful for the treatment of chronic infections in the field of otorhinolaryngology.

We reviewed 64 cases of peritonsillar abscess treated at our clinic between May, 1975 and March, 1988. The patients consisted of 42 males and 22 females, aged 3 to 68 years. The abscess was on the right side in 35 cases, on the left in 28 cases and bilateral in 1 case. Bacteriological study of the abscess revealed a high percentage of α-streptococcus and β-streptococcus in aerobic culture, and Bacteroides sp., Peptostreptococcus sp., and Peptococcus., in anerobic culture. All patients were treated with antibiotics. Removal of abscess by puncture was performed in 23 patients, and incision for drainage was perfomed in 41. Interval tonsillectomy was perfomed in 3 patients and immediate tonsillectomy was perfomed in 1 patient. Recurrent peritonsillar abscess was observed in one patient who had not undergone tonsillectomy. Puncture of abscess, incision for drainage and administration of antibiotics are essential in the treatment of peritonsillar abscess.