8 results on '"Satoko Harada"'
Search Results
2. Collaborative work on evaluation of ovarian toxicity 15) Two- or four-week repeated-dose studies and fertility study of bromocriptine in female rats
- Author
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Zhu Jiuxin, Satoko Harada, Yoshiaki Tagawa, Toshihiko Kumazawa, Hiromi Nishitani, Tsukasa Ishiguro, Takashi Tanaharu, Yukiko Inoue, Ikuo Hayasaka, and Atsushi Nakajima
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Male ,Societies, Scientific ,medicine.medical_specialty ,Longevity ,Fertility Study ,Estrous Cycle ,Ovary ,Toxicology ,Public-Private Sector Partnerships ,Drug Administration Schedule ,Bromocriptine Mesylate ,Antiparkinson Agents ,Rats, Sprague-Dawley ,Japan ,Corpus Luteum ,Pregnancy ,Proliferating Cell Nuclear Antigen ,Internal medicine ,Toxicity Tests ,medicine ,Animals ,Ovarian Diseases ,Adverse effect ,Bromocriptine ,Estrous cycle ,business.industry ,Organ Size ,Rats ,Fertility ,medicine.anatomical_structure ,Endocrinology ,Pituitary Gland ,Toxicity ,Gestation ,Female ,business ,Infertility, Female ,medicine.drug - Abstract
The main focus of this study is to determine the optimal administration period concerning toxic effects on ovarian morphological changes in a repeated-dose toxicity study. To assess morphological and functional changes induced in the ovary by bromocriptine, the compound was administered to female rats at dose levels of 0, 0.08, 0.4 and 2 mg/kg for the 2- or 4-week repeated-dose toxicity study, and for the female fertility study from 2 weeks prior to mating to day 7 of gestation. In the 2-week repeated-dose toxicity study, increase of ovarian weights was observed at 2 mg/kg. In the 4-week repeated-dose toxicity study, ovarian weights were increased at 0.4 and 2 mg/kg. The number of corpora luteum was increased in the 0.4 and 2 mg/kg groups of the 2- and 4-week repeated-dose toxicity studies by histopathological examination of the ovaries. Bromocriptine did not affect estrous cyclicity in 2- and 4-week repeated dosing. In the female fertility study, although animals in any groups mated successfully, no females in 0.4 and 2 mg/kg groups were pregnant. There were no adverse effects on reproductive performance in the 0.08 mg/kg group. Based on these findings, the histopathological changes in the ovary are considered important parameters for evaluation of drugs including ovarian damage. We conclude that a 2-week administration period is sufficient to detect ovarian toxicity of bromocriptine in a repeated-dose toxicity study.
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- 2009
3. Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT1A Receptor in Mice: Implications for Obsessive-Compulsive Disorder
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Kenichi Mishima, Katsunori Iwasaki, Nobuaki Egashira, Michihiro Fujiwara, Ryoko Okuno, Ryoji Nishimura, Michihiko Matsushita, and Satoko Harada
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Male ,Agonist ,Obsessive-Compulsive Disorder ,Indoles ,medicine.drug_class ,Atypical antipsychotic ,Isoindoles ,Motor Activity ,Pharmacology ,Piperazines ,Marble burying ,Mice ,medicine ,Haloperidol ,Animals ,8-Hydroxy-2-(di-n-propylamino)tetralin ,Mice, Inbred ICR ,Risperidone ,Behavior, Animal ,Dose-Response Relationship, Drug ,Chemistry ,lcsh:RM1-950 ,Antagonist ,Perospirone ,Serotonin Receptor Agonists ,Disease Models, Animal ,Thiazoles ,lcsh:Therapeutics. Pharmacology ,Receptor, Serotonin, 5-HT1A ,Molecular Medicine ,5-HT1A receptor ,Serotonin Antagonists ,Antipsychotic Agents ,medicine.drug - Abstract
Perospirone is a novel atypical antipsychotic drug with dopamine (DA) D2- and serotonin (5-hydroxytryptamine, 5-HT) 5-HT2A-receptor antagonist, and 5-HT1A-receptor agonist properties. In the present study, we examined the effect of perospirone on marble-burying behavior, which has been considered an animal model of obsessive-compulsive disorder (OCD), compared with the effects of other antipsychotics such as haloperidol and risperidone. Perospirone at a dose of 10 mg/kg (p.o.) inhibited marble-burying behavior without affecting the locomotor activity in mice. On the other hand, haloperidol (0.1 mg/kg, i.p.) and risperidone (1 mg/kg, p.o.) showed significant suppression of locomotor activity at the dose that inhibited marble-burying behavior. Furthermore, the inhibition of marble-burying behavior by perospirone was antagonized by WAY100135 (10 mg/kg, i.p.), a selective 5-HT1A-receptor antagonist. WAY100135 at the same dose also antagonized the inhibition of marble-burying behavior by 8-OH-DPAT (3 mg/kg, i.p.), a selective 5-HT1A-receptor agonist. These findings suggest that perospirone may exhibit anti-OCD activity in clinical use and that 5-HT1A-receptor agonistic activity may be involved in the inhibition of marble-burying behavior by perospirone. Keywords:: marble-burying behavior, perospirone, antipsychotic drug, 5-HT1A receptor, obsessive-compulsive disorder
- Published
- 2005
4. Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder
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Ryoko Okuno, Nobuaki Egashira, Kenichi Mishima, Satoko Harada, Ryoji Nishimura, Michihiko Matsushita, Ryozo Oishi, Katsunori Iwasaki, and Michihiro Fujiwara
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Male ,Obsessive-Compulsive Disorder ,Reflex, Startle ,Glutamic Acid ,AMPA receptor ,Pharmacology ,Motor Activity ,Receptors, N-Methyl-D-Aspartate ,Marble burying ,chemistry.chemical_compound ,Mice ,Memantine ,Quinoxalines ,medicine ,Amantadine ,Animals ,Prepulse inhibition ,Mice, Inbred ICR ,Riluzole ,Behavior, Animal ,Dizocilpine ,chemistry ,Acoustic Stimulation ,Receptors, Glutamate ,NMDA receptor ,NBQX ,Dizocilpine Maleate ,Excitatory Amino Acid Antagonists ,medicine.drug - Abstract
Clinical evidence demonstrates altered glutamatergic neurotransmission in patients suffering from obsessive–compulsive disorder (OCD). We examined the effects of glutamate-related drugs on marble-burying behavior, which is an animal model of OCD. The uncompetitive N-methyl- d -aspartate (NMDA) antagonists memantine (10 mg/kg, i.p.) and amantadine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity in mice. Similarly, the uncompetitive NMDA receptor antagonist 5R,10S-(+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine hydrogen maleate (MK-801, 0.3 mg/kg, i.p.) inhibited marble-burying behavior. However, MK-801 at the same dose markedly increased locomotor activity. By contrast, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide (NBQX) and the glutamate release inhibitor riluzole showed no effect on marble-burying behavior and significant suppression of locomotor activity. MK-801 (0.3 mg/kg, i.p.) and memantine (10 mg/kg, i.p.) significantly disrupted prepulse inhibition as an operational measure of sensorimotor gating. By contrast, amantadine (30 mg/kg, i.p.) did not affect prepulse inhibition. These findings suggest that amantadine could be a useful drug for the treatment of OCD.
- Published
- 2007
5. Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine
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Katsunori Iwasaki, Ryoko Okuno, Satoko Harada, Ryoji Nishimura, Nobuaki Egashira, Kenichi Mishima, Kensuke Orito, Michihiro Fujiwara, and Michihiko Matsushita
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Male ,Obsessive-Compulsive Disorder ,medicine.drug_class ,Serotonin reuptake inhibitor ,Morpholines ,Sigma receptor ,Fluvoxamine ,Pharmacology ,Piperazines ,Marble burying ,Mice ,Phenazocine ,medicine ,Animals ,Receptors, sigma ,BD-1047 ,Mice, Inbred ICR ,Psychotropic Drugs ,Behavior, Animal ,Dose-Response Relationship, Drug ,Chemistry ,Antagonist ,Brain ,Receptor antagonist ,Ethylenediamines ,Paroxetine ,Butyrates ,Disease Models, Animal ,Selective Serotonin Reuptake Inhibitors ,medicine.drug ,Tropanes - Abstract
In the present study, we examined the involvement of the sigma1 receptor in the inhibitory effect of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine, compared with that of paroxetine, on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Sigma1 receptor agonists (+)-SKF 10047 and PRE-084 significantly inhibited marble-burying behavior. Sigma receptor antagonist BD 1047 and selective sigma1 receptor antagonist BD 1063 significantly attenuated the inhibition of marble-burying behavior by fluvoxamine. In contrast, selective sigma2 receptor antagonist SM-21 failed to affect the inhibition of marble-burying behavior by fluvoxamine. On the other hand, BD 1047 and BD 1063 had no effect on the inhibition of marble-burying behavior by paroxetine. These observations show that activation of the sigma1 receptor is a necessary component in the inhibitory effect of fluvoxamine on marble-burying behavior, and that the mechanism of its action is clearly different from that of paroxetine.
- Published
- 2006
6. Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
- Author
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Katsunori Iwasaki, Gozoh Tsujimoto, Satoko Harada, Tomomi Matsuda, Emi Koushi, Nobuaki Egashira, Yukio Takano, Kenichi Mishima, Michihiro Fujiwara, and Akito Tanoue
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Male ,medicine.medical_specialty ,Vasopressin ,Receptors, Vasopressin ,Neuropeptide ,Anxiety ,Statistics, Nonparametric ,Behavioral Neuroscience ,Mice ,Internal medicine ,medicine ,Animals ,Social Behavior ,Phencyclidine ,Mice, Knockout ,medicine.disease ,Social relation ,Mice, Inbred C57BL ,Endocrinology ,Schizophrenia ,Knockout mouse ,Exploratory Behavior ,Autism ,medicine.symptom ,Psychology ,Neuroscience ,medicine.drug - Abstract
The arginine vasopressin (AVP) system plays an important role in social behavior. Autism, with its hallmark disturbances in social behavior, has been associated with the V1a receptor (V1aR) gene. Furthermore, impairments of social function are often observed in symptoms of schizophrenia. Subchronic phencyclidine (PCP) produces behaviors relating to certain aspects of schizophrenic symptoms such as impairing social interaction in animals and it reduces the density of V1aR binding sites in several brain regions. Here, we report that V1aR knockout (KO) mice exhibited impairment of social behavior in a social interaction test, and showed reduced anxiety-related behavior in elevated plus-maze and marble-burying behavior tests. Given the current findings, the V1aR may be involved in the regulation of social interaction, and V1aR KO mice could be used as an animal model of psychiatric disorders associated with social behavior deficits, such as autism and schizophrenia.
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- 2006
7. Magnetic Field Effects on Photoelectrochemical Reactions of Porphyrin–Viologen Linked Compounds in an Ionic Liquid
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Sunao Yamada, Hiroaki Yonemura, Satoko Harada, and Hironobu Tahara
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Tetrafluoroborate ,Physics and Astronomy (miscellaneous) ,General Engineering ,General Physics and Astronomy ,Viologen ,Photochemistry ,Porphyrin ,Magnetic field ,chemistry.chemical_compound ,Crystallography ,chemistry ,Electrode ,Ionic liquid ,medicine ,Methylene ,Visible spectrum ,medicine.drug - Abstract
Magnetic field effects (MFEs) on photoelectrochemical reactions of three porphyrin–viologen linked compounds with various methylene groups [ZnP(n)V (n=4,6,8)] were examined in 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]) as an ionic liquid using a two-electrode cell. Stable anodic photocurrents are produced by irradiating ZnP(n)V (n=4,6,8) in [BMIM][BF4] with visible light, and the MFEs on photocurrents were clearly observed in ZnP(n)V (n=4,6,8). The MFEs on photocurrents increase with magnetic field for lower magnetic fields (B ≤200 mT) and are constant for higher magnetic fields (B > 200 mT). The magnitude of the MFEs in ZnP(n)V (n=6,8) are larger than that in ZnP(4)V. The MFEs can be explained by radical pair mechanism. The magnitude of the MFEs is larger than those in electrodes modified with ZnP(n)V (n=4,6,8) as Langmuir–Blodgett films. The results are most likely attributable to the properties of [BMIM][BF4] and the mechanism of photoelectrochemical reaction.
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- 2011
8. Magnetic Field Effects on Photoelectrochemical Reactions of a Porphyrin-Viologen Linked Compound in an Ionic Liquid
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Hironobu Tahara, Sunao Yamada, Satoko Harada, and Hiroaki Yonemura
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Photocurrent ,Viologen ,General Chemistry ,Condensed Matter Physics ,Photochemistry ,Porphyrin ,Magnetic field ,chemistry.chemical_compound ,chemistry ,Ionic liquid ,Electrode ,medicine ,General Materials Science ,Methylene ,Visible spectrum ,medicine.drug - Abstract
Magnetic field effects (MFEs) on photoelectrochemical reaction of a porphyrin-viologen linked compound with six methylene group (ZnP(n)V(n = 6)) were examined in an ionic liquid ([BMIM][BF4 ]) using two-electrode cell. A stable anodic photocurrent is produced by irradiating ZnP(6)V in [BMIM][BF4 ] with visible light, and the photocurrent clearly increased in the presence of a magnetic field. The MFEs are explained by radical pair mechanism. The magnitude of the MFEs is larger than those in electrodes modified with ZnP(n)V(n = 4,6,8) as Langmuir-Blodgett films. The results are most likely ascribed to the properties of [BMIM][BF 4 ].
- Published
- 2011
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