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1. A Randomized Clinical Trial of Antimicrobial Duration for Cystic Fibrosis Pulmonary Exacerbation Treatment

Author: Christopher H. Goss, Sonya L. Heltshe, Natalie E. West, Michelle Skalland, Don B. Sanders, Raksha Jain, Tara L. Barto, Barbra Fogarty, Bruce C. Marshall, Donald R. VanDevanter, Patrick A. Flume, Gregory Omlor, Brenda Bourne, Dion Roberts, Vicki Roberts, Samya Nasr, Dawn Kruse, Rachel Linnemann, Tsion Hailemichael, Caralee Forseen, Heidi Stapp, Natalie West, S. Patel, A. Claudio, Jerimiah Lysinger, Amy Harmala, George Solomon, Latona Kersh, Karen Miller, Dixie Durham, Ahmet Uluer, Robert Fowler, Carla Frederick, Nadine Caci, Charlotte Teneback, Julie Sweet, Michael Parkins, Clare Smith, Jennifer Goralski, Kelsey Haywood, Patrick Flume, Caroline Brailsford, Dana Albon, Christie Aderholt, Kimberly McBennett, Cindy Schaefer, Alpa Patel, April Hunt, Lauren Schumacher, Hari Polenakovik, Linda Clark, Jerry Nick, Katie Poch, Dana Kissner, James Cahill, Jorge Lascano, Erin Silverman, John McArdle, Alison Champagne, Robert Vender, Lisa Allwein, Lance Cohen, Norma (Jean) Barton, Tara Barto, Ami Patel, Cynthia Brown, Nia Vorhees, Michael Crosser, Lawrence Scott, Alix Ashare, Barbara Rodgers, Robert Zanni, Lisa Koval, Andrew Braun, Sophia Chiron Stevens, Maria Tupayachi Ortiz, Patricia Graham, Julie Biller, Erin Hubertz, Kathryn Moffett, Tammy Clark, Rebecca Griffith, Nancy Martinez, Sabiha Hussain, Fei Chen, Marie Egan, Catalina Guzman, Janice Wang, Aileen Espinal, Patricia Walker, Anne Kukral, Emily DiMango, Sarah Fracasso Francis, Carlos Milla, Colleen Dunn, Subramanyam Chittivelu, Ashley Scott, Daniel Dorgan, Sharon Ng, Joseph Pilewski, Rose Lanzo, Nauman Chaudary, Ryan Hayden, Steven Scofield, Barb Johnson, Brian Morrissey, Brandt Robinson, Douglas Conrad, Jenna Mielke, Moira Aitken, Chami Sanlors, Ravi Nayak, Freda Branch, Daniel Rosenbluth, Molly Siegel, Anil Ghimire, Mary Forell, Cori Daines, Monica Varela, Leslie Couch, Rebekah Hibbard, Allen Dozor, Armando Ramirez, Victor Ortega, Kathryn Kennedy, David Fish, and Karen Longtine
Subjects: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Time Factors, Cystic Fibrosis, Exacerbation, Critical Care and Intensive Care Medicine, Cystic fibrosis, law.invention, Randomized controlled trial, law, Internal medicine, medicine, Humans, Pseudomonas Infections, Respiratory system, Respiratory Tract Infections, business.industry, Cystic Fibrosis Pulmonary Exacerbation, Editorials, Respiratory infection, Original Articles, Middle Aged, medicine.disease, Antimicrobial, Anti-Bacterial Agents, Respiratory Function Tests, Clinical trial, Pseudomonas aeruginosa, Disease Progression, Female, business
Abstract: RATIONALE: People with cystic fibrosis (CF) experience acute worsening of respiratory symptoms and lung function known as pulmonary exacerbations. Treatment with intravenous antimicrobials is common; however, there is scant evidence to support a standard treatment duration. OBJECTIVES: To test differing durations of intravenous antimicrobials for CF exacerbations. METHODS: STOP2 (Standardized Treatment of Pulmonary Exacerbations 2) was a multicenter, randomized, controlled clinical trial in exacerbations among adults with CF. After 7–10 days of treatment, participants exhibiting predefined lung function and symptom improvements were randomized to 10 or 14 days’ total antimicrobial duration; all others were randomized to 14 or 21 days’ duration. MEASUREMENTS AND MAIN RESULTS: The primary outcome was percent predicted FEV(1) (ppFEV(1)) change from treatment initiation to 2 weeks after cessation. Among early responders, noninferiority of 10 days to 14 days was tested; superiority of 21 days compared with 14 days was compared for the others. Symptoms, weight, and adverse events were secondary. Among 982 randomized people, 277 met improvement criteria and were randomized to 10 or 14 days of treatment; the remaining 705 received 21 or 14 days of treatment. Mean ppFEV(1) change was 12.8 and 13.4 for 10 and 14 days, respectively, a ‒0.65 difference (95% CI [‒3.3 to 2.0]), excluding the predefined noninferiority margin. The 21- and 14-day arms experienced 3.3 and 3.4 mean ppFEV(1) changes, a difference of ‒0.10 (‒1.3 to 1.1). Secondary endpoints and sensitivity analyses were supportive. CONCLUSIONS: Among adults with CF with early treatment improvement during exacerbation, ppFEV(1) after 10 days of intravenous antimicrobials is not inferior to 14 days. For those with less improvement after one week, 21 days is not superior to 14 days. Clinical trial registered with www.clinicaltrials.gov (NCT02781610).
Published: 2021

2. Association of site of treatment with clinical outcomes following intravenous antimicrobial treatment of a pulmonary exacerbation

Author: M. Skalland, Christopher H. Goss, Patrick A. Flume, Natalie E. West, Umer Khan, Sonya L. Heltshe, Donald R. VanDevanter, and Don B. Sanders
Subjects: Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Randomization, Cystic Fibrosis, business.industry, Antimicrobial, medicine.disease, Cystic fibrosis, Article, Anti-Bacterial Agents, Clinical trial, Respiratory symptom, Anti-Infective Agents, Internal medicine, Pediatrics, Perinatology and Child Health, Propensity score matching, Humans, Medicine, Administration, Intravenous, business, Lung, Lung function, Pulmonary exacerbation
Abstract: BACKGROUND: In the STOP2 (Standardized Treatment of Pulmonary Exacerbations-2) study, intravenous (IV) antimicrobial treatment duration for adults with cystic fibrosis (CF) experiencing pulmonary exacerbations (PEx) was determined based on initial treatment response. The impact of home vs hospital care remains an important clinical question in CF. Our hypothesis was that STOP2 participants treated at home would have less improvement in lung function compared to those treated in the hospital. METHODS: Treating clinicians determined PEx treatment location, which was a stratification factor for STOP2 randomization. Lung function, weight, and symptom recovery were evaluated by treatment location. Propensity scores and inverse probability treatment weighting were used to test for differences in clinical response by treatment location. RESULTS: In all, 33% of STOP2 participants received IV antimicrobials in the hospital only, 46% both in the hospital and at home, and 21% at home only. Mean (95% CI) ppFEV(1) improvement was significantly (p
Published: 2022

3. Trans-Myocardial Blood Interleukin-6 Levels Relate to Intracoronary Imaging-Defined Features of Plaque Vulnerability and Predict Procedure-Induced Myocardial Infarction

Author: Marta Peverelli, Paul Bambrough, Stephen P. Hoole, Martin R. Bennett, Nick E.J. West, Adam J. Brown, and Joel P. Giblett
Subjects: medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Coronary Artery Disease, medicine.disease_cause, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, Myocardial infarction, Ultrasonography, Interventional, Coronary sinus, biology, Interleukin-6, business.industry, Percutaneous coronary intervention, General Medicine, Venous blood, Atherosclerosis, medicine.disease, Vulnerable plaque, Troponin, Plaque, Atherosclerotic, biology.protein, Cardiology, Biomarker (medicine), Cardiology and Cardiovascular Medicine, business, Biomarkers, Blood sampling
Abstract: Background Intravascular imaging has defined various vulnerable plaque (VP) phenotypes that predict future clinical events. Atherosclerosis is an inflammatory process and inflammation, measured by systemic biomarkers can also predict events and anti-inflammatory therapy is beneficial. We were interested to assess the relationship between plaque phenotypes and key inflammatory biomarkers, measured close to the coronary. Methods Ninety-two patients scheduled for elective percutaneous coronary intervention (PCI) underwent virtual histology intravascular ultrasound, optical coherence tomography, pressure wire and blood sampling from the guide catheter (GC), coronary sinus (CS) to determine trans-myocardial gradient (TMG = CS-GC) and from peripheral blood. Procedure related troponin release was assessed at 6-hours post-PCI from peripheral venous blood. Biomarker data were analysed and compared with coronary data. Results Interleukin (IL)-6 was associated with increased levels of tumour necrosis factor (TNF)-α and C-reactive protein (CRP) and the pre-PCI IL-6 TMG correlated with plaque features of vulnerability: plaque burden - PB (r = 0.253, p = 0.04) and minimal lumen area - MLA (r = −0.438, p = 0.007), although no relationship existed for thin-capped fibroatheroma defined by either imaging modality. Peripheral IL-6 levels had no correlation with post PCI troponin, although the pre-PCI IL-6 TMG was related (r = 0.334, p = 0.006), as was PB (r = 0.27, p = 0.029). Conclusion IL-6 TMG pre-PCI correlates with plaque burden and MLA that have been shown to predict future clinical events and is correlated with post-PCI troponin release. These associations were not apparent from peripheral blood and suggest that local coronary biomarker signatures may help further define vulnerability and risk.
Published: 2022

4. Utility of photography for trachoma surveys: A systematic review

Author: Christopher J. Brady, Fahd Naufal, and Sheila K. West
Subjects: Inflammation, Trachoma, business.industry, education, Photography, Infant, Prevalence survey, medicine.disease, Ophthalmology, Prevalence, medicine, Humans, Optometry, Grading (education), business, Conjunctiva, Trichiasis, Kappa
Abstract: As trachoma prevalence declines worldwide, performing field surveys with trained trachoma graders to validate its elimination becomes challenging. Graded conjunctival images could be used to train graders, validate field grades, and replace field grading. We review the use of photography to capture conjunctival images for the detection of trachomatous inflammation-follicular (TF) and -intense (TI), Trachomatous trichiasis (TT), and eyelid contour abnormalities. Literature searches were conducted between October 29, 2020 and February 15, 2021. We abstracted kappa scores for agreement between field and image graders, between field graders, and between image graders. The median kappa was calculated for studies discussing grading for TF and TI. Twenty-one studies were included - 19 described the use of imaging tools for grading TF and TI; 1 discussed TT; and 1 discussed eyelid contour abnormalities. For agreement between field and image graders, median kappa for TF was 0.71 (range: 0.57–0.92) and TI was 0.67 (0.37–0.74); between image graders, median kappa for TF was 0.65 (0.37–0.78) and TI was 0.76 (0.39–0.83); and between field graders, median kappa for TF was 0.86 (0.73–1) and TI was 0.82 (0.73–0.91). There is potential for the use of photography for trachoma prevalence surveys. Further research is warranted, particularly for TT and using newer smartphones.
Published: 2022

5. Longitudinal Changes in Scotopic and Mesopic Macular Function as Assessed with Microperimetry in Patients With Stargardt Disease: SMART Study Report No. 2

Author: Isabelle Audo, Michel Michaelides, Eberhart Zrenner, Alexander Ho, Michael S. Ip, Janet S. Sunness, Sheila K. West, Artur V. Cideciyan, David G. Birch, Millena Bittencourt, Ann-Margaret Ervin, Srinivas R. Sadda, Mohamed Ibrahim-Ahmed, Rupert W. Strauss, Hendrik P. N. Scholl, and Xiangrong Kong
Subjects: Fovea Centralis, medicine.medical_specialty, genetic structures, Mesopic vision, Visual Acuity, ABCA4, Article, Macular Degeneration, Study report, Ophthalmology, medicine, Humans, Stargardt Disease, Prospective Studies, Scotopic vision, Prospective cohort study, biology, business.industry, medicine.disease, eye diseases, Macular function, Stargardt disease, Cross-Sectional Studies, biology.protein, Visual Field Tests, ATP-Binding Cassette Transporters, sense organs, business, Microperimetry, Tomography, Optical Coherence
Abstract: PURPOSE: To estimate and compare cross-sectional scotopic versus mesopic macular sensitivity losses measured by microperimetry, and to report and compare the longitudinal rates of scotopic and mesopic macular sensitivity losses in ABCA4 gene associated Stargardt Disease (STGD1). DESIGN: Multicenter prospective cohort study. METHODS: PARTICIPANTS: 127 molecular confirmed STGD1 patients enrolled from 6 centers in the USA and Europe and followed every 6 months for up to 2 years. OBSERVATION PROCEDURES: The Nidek MP-1S device was used to measure macular sensitivities of the central 20° under mesopic and scotopic conditions. The mean deviations (MD) from normal for mesopic macular sensitivity for the fovea (within 2° eccentricity) and extrafovea (4°−10° eccentricity), and the MD for scotopic sensitivity for the extrafovea were calculated. Linear mixed effects models were used to estimate mesopic and scotopic changes. MAIN OUTCOME MEASURES: Baseline mesopic mean deviation (mMD) and scotopic MD (sMD) and rates of longitudinal changes in the mMDs and sMD. RESULTS: At baseline, all eyes had larger sMD, and the difference between extrafoveal sMD and mMD was 10.7 dB (p
Published: 2022

6. The financial challenges for Australian nursing students attending placement-based work-integrated learning

Author: Annette Marlow, Anthea Fagan, Victoria R. Terry, Thea F van de Mortel, Marie Hutchinson, Caryn West, Carey Mather, Tamara Power, Janie Brown, Kim Usher, Jackie Lea, Lin Zhao, and Cindy Woods
Subjects: Finance, Integrated learning, business.industry, media_common.quotation_subject, 1110 Nursing, Nursing, medicine.disease, Scholarship, Work (electrical), Debt, Workforce, medicine, Financial strain, Attrition, business, Psychology, Accommodation, General Nursing, media_common
Abstract: Background: Mandatory placement-based work-integrated learning (WIL) poses challenges for nursing students who work whilst studying. The financial burden of WIL links to other known direct and indirect challenges, yet no Australian study has quantified the financial challenges resulting from attending mandatory WIL placements. Placement-based WIL costs may preclude some students from completing WIL, which may impact student attrition and the future health workforce. Aim: To investigate Australian nursing students’ financial challenges related to mandatory WIL. Methods: An online cross-sectional survey conducted with nursing students from nine Australian universities across five Australian states. The 28-question survey investigated the location of, and travels to, the most recent WIL placement; and students’ employment, accommodation, financial support, expenses and debts, and financial strain pertaining to WIL placements. Results: Overall, 2,359 students participated. The majority were employed (84%); 65% of these reported that they were unable to work during WIL, affecting their employment. One-third incurred a financial liability from their placement, 79% reported financial hardship, and 73% found their placement stressful due to financial strain. Financial issues affected 62% of students’ health and wellbeing. Discussion: Financial pressures related to WIL impact nursing students. While students have strategies to reduce these pressures, universities can also better manage their placement preferencing and support of students to reduce financial impacts of placement-based WIL on students. Conclusions: Nursing students face substantial financial challenges related to placement-based WIL. Scholarship programs and other forms of support are required to assist nursing students to undertake WIL.
Published: 2022

7. Deep learning identifies inflamed fat as a risk factor for lymph node metastasis in early colorectal cancer

Author: Jakob Nikolas Kather, Marie Louise Malmstrøm, Tine Plato Kuhlmann, Nicholas P. West, I. Gögenur, Heike I. Grabsch, Narmin Ghaffari Laleh, Katarina Levic, Lara R. Heij, Susanne Eiholm, Oliver Lester Saldanha, Aurora Bono, Amelie Echle, Katerina Kouvidi, Titus J. Brinker, Philip Quirke, Scarlet Brockmoeller, RS: GROW - R2 - Basic and Translational Cancer Biology, Pathologie, MUMC+: DA Pat AIOS (9), and MUMC+: DA Pat Pathologie (9)
Subjects: Oncology, POLYPS, medicine.medical_specialty, Colorectal cancer, MICROSATELLITE INSTABILITY, PREDICTION, Biopsy, pT1 and pT2 bowel cancer, new predictive biomarker, Disease, Proof of Concept Study, Risk Assessment, Pathology and Forensic Medicine, Metastasis, Predictive Value of Tests, Risk Factors, Internal medicine, Image Interpretation, Computer-Assisted, medicine, Humans, metastasis, Diagnosis, Computer-Assisted, Biomarker discovery, Risk factor, Early Detection of Cancer, Neoplasm Staging, Retrospective Studies, Microscopy, Receiver operating characteristic, business.industry, inflamed adipose tissue, Digital pathology, Cancer, Reproducibility of Results, deep learning, medicine.disease, artificial intelligence, early colorectal cancer, prediction LNM, MODEL, INTEROBSERVER VARIABILITY, Adipose Tissue, AI, Lymphatic Metastasis, Lymph Nodes, business, Colorectal Neoplasms, digital pathology
Abstract: The spread of early-stage (T1 and T2) adenocarcinomas to locoregional lymph nodes is a key event in disease progression of colorectal cancer (CRC). The cellular mechanisms behind this event are not completely understood and existing predictive biomarkers are imperfect. Here, we used an end-to-end deep learning algorithm to identify risk factors for lymph node metastasis (LNM) status in digitized histopathology slides of the primary CRC and its surrounding tissue. In two large population-based cohorts, we show that this system can predict the presence of more than one LNM in pT2 CRC patients with an area under the receiver operating curve (AUROC) of 0.733 (0.67-0.758) and patients with any LNM with an AUROC of 0.711 (0.597-0.797). Similarly, in pT1 CRC patients, the presence of more than one LNM or any LNM was predictable with an AUROC of 0.733 (0.644-0.778) and 0.567 (0.542-0.597), respectively. Based on these findings, we used the deep learning system to guide human pathology experts towards highly predictive regions for LNM in the whole slide images. This hybrid human observer and deep learning approach identified inflamed adipose tissue as the highest predictive feature for LNM presence. Our study is a first proof of concept that artificial intelligence (AI) systems may be able to discover potentially new biological mechanisms in cancer progression. Our deep learning algorithm is publicly available and can be used for biomarker discovery in any disease setting. © 2021 The Pathological Society of Great Britain and Ireland. Published by John WileySons, Ltd.
Published: 2022

8. ASXL1 and STAG2 are common mutations in GATA2 deficiency patients with bone marrow disease and myelodysplastic syndrome

Author: Robert R. West, Dennis D. Hickstein, Desiree Tillo, Amy P. Hsu, Weixin Wang, Thomas R. Bauer, Katherine R. Calvo, Stephenie Droll, Justin B. Lack, Laura M. Tuschong, Lisa J. Embree, and Steven M. Holland
Subjects: Myeloid, GATA2 Deficiency, Cell Cycle Proteins, Disease, medicine.disease_cause, Trisomy 8, Germline mutation, Neoplasms, medicine, Humans, Chromosome 7 (human), Mutation, Myeloproliferative Disorders, business.industry, Hematology, medicine.disease, GATA2 Transcription Factor, Repressor Proteins, medicine.anatomical_structure, Myelodysplastic Syndromes, Immunology, Disease Progression, Female, Bone marrow, business
Abstract: Patients with GATA2 deficiencyharbor de novo or inherited germline mutations in the GATA2 transcription factor gene, predisposing them to myeloid malignancies. There is considerable variation in disease progression, even among family members with the same mutation in GATA2. We investigated somatic mutations in 106 patients with GATA2 deficiency to identify acquired mutations that are associated with myeloid malignancies. Myelodysplastic syndrome (MDS) was the most common diagnosis (∼44%), followed by GATA2 bone marrow immunodeficiency disorder (G2BMID; ∼37%). Thirteen percent of the cohort had GATA2 mutations but displayed no disease manifestations. There were no correlations between age or sex with disease progression or survival. Cytogenetic analyses showed a high incidence of abnormalities (∼43%), notably trisomy 8 (∼23%) and monosomy 7 (∼12%), but the changes did not correlate with lower survival. Somatic mutations in ASXL1 and STAG2 were detected in ∼25% of patients, although the mutations were rarely concomitant. Mutations in DNMT3A were found in ∼10% of patients. These somatic mutations were found similarly in G2BMID and MDS, suggesting clonal hematopoiesis in early stages of disease, before the onset of MDS. ASXL1 mutations conferred a lower survival probability and were more prevalent in female patients. STAG2 mutations also conferred a lower survival probability, but did not show a statistically significant sex bias. There was a conspicuous absence of many commonly mutated genes associated with myeloid malignancies, including TET2, IDH1/2, and the splicing factor genes. Notably, somatic mutations in chromatin-related genes and cohesin genes characterized disease progression in GATA2 deficiency.
Published: 2022

9. Adult allergic rhinitis sufferers have unique nasal mucosal and peripheral blood immune gene expression profiles: A case–control study

Author: Allan W. Cripps, Nicholas P. West, Annabelle M. Watts, Amanda J. Cox, and Peter K. Smith
Subjects: Chemokine, Allergy, Immunology, Mucous membrane of nose, Immunoglobulin E, Immune system, rhinitis, medicine, Humans, Immunology and Allergy, CCL17, mucosa, Innate immune system, biology, business.industry, Original Articles, Eosinophil, RC581-607, medicine.disease, Rhinitis, Allergic, Nasal Mucosa, Cross-Sectional Studies, medicine.anatomical_structure, Case-Control Studies, biology.protein, gene expression, Original Article, Immunologic diseases. Allergy, Transcriptome, business, epithelium
Abstract: Background Allergic rhinitis (AR) is a complex disease involving both mucosal and systemic immune compartments. Greater understanding of the immune networks underpinning AR pathophysiology may assist with further refining disease‐specific biomarkers. Objective To compare immune gene expression profiles in nasal mucosa and peripheral blood samples between adults with AR and controls without AR. Methods This cross‐sectional study included 45 adults with moderate‐severe and persistent AR (37.6 ± 12.8 years; mean ± SD) and 24 adults without AR (36.6 ± 10.2). Gene expression analysis was performed using the NanoString nCounter PanCancer Immune profiling panel (n = 730 immune genes) in combination with the panel plus probe set (n = 30 allergy‐related genes) with purified RNA from peripheral blood and cell lysates prepared from combined nasal lavage and nasal brushing. Results One hundred and thirteen genes were significantly differentially expressed in peripheral blood samples between groups (p, A series of genes were differentially expressed in both peripheral blood and nasal mucosal samples from adults with moderate‐severe persistent allergic rhinitis compared with adults without a history of allergic rhinitis.
Published: 2022

10. Crossed Screw Fixation Versus Dorsal Plating for First Metatarsophalangeal Joint Arthrodesis: A Retrospective Cohort Study

Author: Tenaya A. West, Sandeep Patel, Jonathan DeTommaso, Jason D. Pollard, and Diane M. Carpenter
Subjects: Metatarsophalangeal Joint, medicine.medical_specialty, Bone Screws, Arthrodesis, Osteoarthritis, 03 medical and health sciences, Hallux rigidus, 0302 clinical medicine, Interquartile range, Hallux Rigidus, medicine, Humans, Orthopedics and Sports Medicine, Hallux Valgus, Retrospective Studies, Fixation (histology), 030222 orthopedics, business.industry, Retrospective cohort study, 030229 sport sciences, Odds ratio, medicine.disease, Confidence interval, Surgery, Rheumatoid arthritis, business, Bone Plates
Abstract: Multiple fixation techniques for first metatarsophalangeal joint arthrodesis have been described with an average fusion rate of 93.5%. This retrospective cohort study assesses the association between crossed screws (vs dorsal plating) and medical comorbidities and the outcome radiographic union. Bivariate tests of association and multivariable logistic regression were employed to assess differences across fixation type and outcomes. We identified 305 patients who underwent a first metatarsophalangeal joint arthrodesis during the study period. Crossed screw fixation was used in 158 (51.8%) patients while dorsal plating (tubular or anatomic locking plate) was used in 147 (48.2%) patients. Dorsal plating was utilized more often in patients with rheumatoid arthritis (p = .019) and history of smoking (p = .044). At 12 weeks post-operatively there were no significant differences in fusion rates between the two groups (crossed screw group = 95.3% vs dorsal plate group (referent) = 93.5%, Adjusted odds ratio (AOR) 1.39, 95% confidence interval [CI] 0.45-4.26). Not smoking was associated with a greater odds of fusion at 12 weeks (96.2% for nonsmokers vs 75.0% for smokers (referent), AOR 0.07, 95% CI 0.02-0.28). Lower body mass index was associated with a greater odds of fusion at 12 weeks (AOR 0.90, 95% CI 0.82-0.99). Surgeons allowed weightbearing earlier with dorsal plate fixation (2 weeks (interquartile range [IQR] 2.6) versus 5 weeks (IQR 2.6) for crossed screw fixation, p = .001). Patients with multiple medical comorbidities were more likely to require revision surgery than patients having 0-1 comorbidities (p.05). Crossed screws can provide an inexpensive yet effective option for first metatarsophalangeal joint arthrodesis.
Published: 2022

11. Gynecologic oncologist impact on adjuvant chemotherapy care for stage II-IV ovarian cancer patients

Author: Charles F. Lynch, Mary E. Charlton, Michael O'Rorke, Sherri L. Stewart, Michele M. West, Megan E McDonald, Ryan M. Carnahan, Jacob Oleson, and Kristin S. Weeks
Subjects: Adult, Rural Population, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Antineoplastic Agents, Health Services Accessibility, Medical Records, Midwestern United States, Cohort Studies, Young Adult, medicine, Humans, Practice Patterns, Physicians', Stage (cooking), Aged, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, Oncologists, Ovarian Neoplasms, Chemotherapy, business.industry, Proportional hazards model, Medical record, General surgery, Obstetrics and Gynecology, Retrospective cohort study, Odds ratio, Middle Aged, medicine.disease, Oncology, Chemotherapy, Adjuvant, Female, Ovarian cancer, business, Gynecologic Oncologist
Abstract: Objective We aim to evaluate the impact gynecologic oncologists have on ovarian cancer adjuvant chemotherapy care from their role as surgeons recommending adjuvant chemotherapy care and their role as adjuvant chemotherapy providers while considering rural-urban differences. Methods Multivariable adjusted logistic regressions and Cox proportional hazards models were developed using a population-based, retrospective cohort of stage II-IV and unknown stage ovarian cancer patients diagnosed in Iowa, Kansas, and Missouri in 2010–2012 whose medical records were abstracted in 2017–2018. Results Gynecologic oncologist surgeons (versus other type of surgeon) were associated with increased odds of adjuvant chemotherapy initiation (adjusted odds ratio (OR) 2.18; 95% confidence interval (CI) 1.10–4.33) and having a gynecologic oncologist adjuvant chemotherapy provider (OR 10.0; 95% CI 4.58–21.8). Independent of type of surgeon, rural patients were less likely to have a gynecologic oncologist chemotherapy provider (OR 0.52; 95% CI 0.30–0.91). Gynecologic oncologist adjuvant chemotherapy providers (versus other providers) were associated with decreased surgery-to-chemotherapy time (rural: 6 days; urban: 8 days) and increased distance to chemotherapy (rural: 22 miles; urban: 11 miles). Rural women (versus urban) traveled 38 miles farther when their chemotherapy provider was a gynecologic oncologist and 27 miles farther when it was not. Conclusion Gynecologic oncologist surgeons may impact adjuvant chemotherapy initiation. Gynecologic oncologists serving as adjuvant chemotherapy providers were associated with some care benefits, such as reduced time from surgery-to-chemotherapy, and some care barriers, such as travel distance. The barriers and benefits of having a gynecologic oncologist involved in adjuvant chemotherapy care, including rural-urban differences, warrant further research in other populations.
Published: 2022

12. Visual impairment, severe visual impairment, and blindness in children in Britain (BCVIS2): a national observational study

Author: Lucinda J Teoh, Ameenat Lola Solebo, Jugnoo S Rahi, Joe Abbott, Wajda Abdullah, Gill Adams, Louise Allen, Christopher Anderson, Karen Ansell, Samira Anwar, Isabel Ash, Jane Ashworth, Sher Aslam, Majunath Astagi, Colin Ball, Rajesh Balu, Victoria Barrett, Zahabiyah Bassi, Adam Bates, Dushyant Batra, Sarah Bell, Linda Belmour, James Benzimra, Ginny Birrell, Susmito Biswas, Andrew Blaikie, Michael Blundell, Kate Bolton, Ewoud Bos, Pamela Bowen, Richard Bowman, Natalie Boyle, John Bradbury, Maria Bredow, Marsel Bregu, Nicholas Brennan, Rosie Brennan, Paul Brittain, Charles Buchanan, Catey Bunce, Howard Bunting, Priscilla Burgess, Cathie Burke, Alexandra Kate Bush, Jeremy Butcher, Lucilla Butler, Clare Cane, Cathryn Chadwick, Ruth Charlton, Anne-Marie Childs, Jessy Choi, Vivi Choleva, Amanda Churchill, Michael Clarke, Peter Clayton, Luke Clifford, Alan Connor, Rachel Cox, Lyn Cresswell, Annegret Dahlmann-Noor, Angela D'Amore, Mehul Dattani, Fiona Dean, Anita Devlin, Luna Dhir, Cora Doherty, Suzanne Dorey, Fiona Drimmie, Tina Duke, Gordon Dutton, Fiona Eaton, Megan Eaton, Danielle Eckersley, Clive Edelsten, Rachel Elderkin, Julia Ennis, Julia Escardo-Paton, Ziad Estephen, Onajite Etuwewe, Anthony Evans, Adjoa Ezekwe, Jenny Fairfield, Kevin Falzon, Allison Ferguson, Brian Fleck, Mary Gainsborough, Alexandra Galloway, Naomi Gerson-Sofer, Caspar Gibbon, Patricia Gibson, Kevin Goss, Katherine Graham-Evans, Judith Gray, Anna Gregory, Arun Gulati, Deniz Gurtin-Zorkun, Emma Guy, Diab Haddad, Helen Haggerty, Paul Haigh, Julia Hale, Samer Hamada, Joanne Hancox, Kerry Hanna, Sian Harris, Christine Harrison, Phillip Harvey, Sophie Headland, Dominic Heath, Paul Heaton, Robert Henderson, Melanie Hingorani, Zoe Hirst, Claire Hogg, Wolfgang Hogler, Roger Holden, Janice Hoole, Karen Horridge, Delyth Howard, Rachel Howells, Vanessa Irvine, Clare Irving, Nicola Johnson, Ian Johnston, Alice Jollands, David Jones, Annie Joseph, Archana Joshi, Pugazhvendan Kandaswamy, Charles Kattakayam, Joseph Keenan, Anne Kelly, James Kersey, Awais Khan, Peng Khaw, Tina Kipioti, Sadia Kiran, Lesley Kneen, Ajay Kotagiri, Richa Kulshrestha, Rosemary Lambley, Tim Lavy, Joanna Lawson, Vicki Lee, Jane Leitch, Julie Lennon, Gabi Lipshen, Chris Lloyd, John Loftus, Tom Lomas, Vernon Long, Jane Mackinnon, Mary MacRae, Usman Mahmood, Anna Maino, Sarah Maling, David Mansfield, Elizabeth Marder, Richard Markham, Jane Marr, Catherine Marsh, Anna Maw, Eleanor McCartney, Helen McCullagh, Anna McDonald, Derek McPhee, Lawrence Miall, Shila Mistry, Benjamin Moate, Meyyammai Mohan, Helen Moore, Will Moore, Nicola Morgan, Claire Morton, Alan Mulvihill, Ranjit Nair, Bill Newman, Christiane Nitsch, Katy O'Connell, Ngozi Oluonye, Vittaldas Pai, Helen Palmer, Maria Papadopoulos, Shelagh Parkinson, Bina Parmar, Manoj Parulekar, Madhavi Parvathareddy, Dipesh Patel, Himanshu Patel, Kamal Patel, Philippa Pennefather, Flaudia Petrone, Marcus Pierrepoint, Rachel Pilling, Sally Pollard, Renata Puertas, Karen Pysden, Anthony Quinn, Philip Quinn, Diyaa Rachdan, Jyoti Raina, Saul Rajak, Laura Ramm, Catherine Rands, Tekki Rao, Mary Ray, Ashwin Reddy, Sheilla Reilly, Maralla Rekha, Greg Richardson, Andrew Riordan, Nerys Roberts, Helen Robertson, Gillian Robinson, Neil Rogers, Shakir Saeed, Caroline Salmon, Jenefer Sargent, Nagini Sarvananthan, Conrad Schmoll, James Self, P Sellar, Elaine Service, Ayad Shafiq, Shilpa Shah, Vinod Sharma, Jemima Sharp, Julia Shaw, Manjula Shenoy, Tamsin Sleep, Elisa Smit, Katherine Smyth, Lynne Speedwell, Katherine Spowart, P Standring, Paulo Stanga, Alison Stanley, Alan Stanton, David Steel, John Stephen, Catherine Stewart, Jessica Street, Sally Stucke, Shona Sutherland, Katya Tambe, Anamika Tandon, Alison Tappin, Kate Taylor, Robert Taylor, Katherine Teasdale, Maria Theodorou, Gareth Thomas, Megan Thomas, Paula Thomas, Dorothy Thompson, Stephen Thomson, Indrajit Thopte, Peter Tiffin, Angela Tillett, Heidi Traunecker, Maria Tsimpida, Vivienne Van Someren, Udupa Venkatesh, Zoe Vermaak, Michael Vincent, David Walker, Simon Walker, Deidre Walsh, Bronwyn Walters, Martin Ward Platt, Louise Watson, Patrick Watts, Siobhan West, Stephanie West, Cathy White, Joy White, Gabriel Whitlingum, Cathy Williams, Sophie Wilne, Janice Wilson, Chien Wong, Tamsin Woodbridge, Paul Wright, Martha Wyles, and Philip Wylie
Subjects: Male, medicine.medical_specialty, Pediatrics, Adolescent, genetic structures, Cross-sectional study, Visual impairment, Vision Disorders, Blindness, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Epidemiology, Health care, Ethnicity, Developmental and Educational Psychology, medicine, Humans, Cumulative incidence, 030212 general & internal medicine, Child, business.industry, Incidence, Incidence (epidemiology), Infant, Newborn, Childhood blindness, Infant, medicine.disease, United Kingdom, eye diseases, Cross-Sectional Studies, Socioeconomic Factors, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Observational study, medicine.symptom, business
Abstract: Summary Background The WHO VISION 2020 global initiative against blindness, launched in 2000, prioritised childhood visual disability by aiming to end avoidable childhood blindness by 2020. However, progress has been hampered by the global paucity of epidemiological data concerning childhood visual disability. The British Childhood Visual Impairment and Blindness Study 2 (BCVIS2) was done to address this evidence gap. Methods BCVIS2 was a prospective UK-wide, cross-sectional, observational study to establish an inception cohort of children newly diagnosed with visual impairment. Ophthalmologists and paediatricians reported cases from 89 hospitals and community centres across the UK. We included children aged 18 years or younger who were newly diagnosed with any condition causing impaired visual acuity to a level of 0·5 logMAR or worse (worse than 6/18 Snellen) in each eye, or equivalent vision as assessed by standard qualitative measures, between Oct 1, 2015, and Nov 1, 2016. Eligible children were notified simultaneously but independently by their managing ophthalmologists and paediatricians via the two national active surveillance schemes, the British Ophthalmological Surveillance Unit and the British Paediatric Surveillance Unit. Standardised detailed demographic, socioeconomic, and clinical data about detection, management, and treatment were collected at diagnosis and 1 year later. We calculated incidence estimates and relative rates by key sociodemographic factors. We did descriptive analyses of underlying ophthalmic disorders and non-ophthalmic comorbidities. Findings 61 (7%) of 845 eligible children initially notified were ineligible at follow-up because of improved vision after treatment. Thus, the study sample comprised 784 children with permanent newly-diagnosed all-cause visual impairment, severe visual impairment, or blindness. 559 (72%) of 778 children had clinically significant non-ophthalmic impairments or conditions. 28 (4%) of 784 children died within a year after diagnosis of visual disability (all had underlying systemic disorders). Incidence of visual disability in the first year of life was 5·19 per 10 000 children (95% CI 4·71–5·72), almost ten times higher than among 1-to-4-year-olds and between 20 times and 100 times higher than in the older age groups. The overall cumulative incidence (or lifetime risk) of visual impairment, severe visual impairment, or blindness was 10·03 per 10 000 children (9·35–10·76). Incidence rates were higher for those from any ethnic minority group, the lowest quintile of socioeconomic status, and those born preterm or with low birthweight. 345 (44%) of 784 children had a single affected anatomical site. Disorders of the brain and visual pathways affected 378 (48%) of 784 children. Interpretation BCVIS2 provides a contemporary snapshot of the heterogeneity, multi-morbidity, and vulnerability associated with childhood visual disability in a high-income country. These findings could facilitate developing and delivering health care and planning of interventional research. Our findings highlight the importance of including childhood visual disability as a sentinel event and metric in global child health initiatives. Funding Fight for Sight, National Institute for Health Research, and Ulverscroft Foundation.
Published: 2021

13. Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics

Author: Jacob A. Davis, Misty M Strain, Rajesh C. Miranda, Gizelle Nicole Fauss, Rachel E. Baine, James W. Grau, Christopher West, Melissa K. Henwood, Joshua A. Reynolds, David T. Johnston, and Yung-Jen Huang
Subjects: Male, Pain, Hemodynamics, Hemorrhage, Rats, Sprague-Dawley, Norepinephrine (medication), Risk Factors, Prazosin, Noxious stimulus, Animals, Medicine, Spinal cord injury, Spinal Cord Injuries, business.industry, Original Articles, Blood flow, medicine.disease, Rats, Disease Models, Animal, Blood pressure, Anesthesia, Shock (circulatory), Neurology (clinical), medicine.symptom, business, Locomotion, medicine.drug
Abstract: Nociceptive input diminishes recovery and increases lesion area after a spinal cord injury (SCI). Recent work has linked these effects to the expansion of hemorrhage at the site of injury. The current paper examines whether these adverse effects are linked to a pain-induced rise in blood pressure and/or flow. Male rats with a low-thoracic spinal cord injury were treated with noxious input [electrical stimulation (shock) or capsaicin] soon after injury. Locomotor recovery and blood pressure were assessed throughout. Tissues were collected three hours, 24 hours, or 21 days later. Both electrical stimulation and capsaicin undermined locomotor function and increased the area of hemorrhage. Changes in blood pressure/flow varied depending on type of noxious input, with only shock producing changes in blood pressure. Providing behavioral control over the termination of noxious stimulation attenuated the rise in blood pressure and hemorrhage. Pretreatment with the alpha-1 adrenergic receptor inverse agonist, prazosin, reduced the stimulation-induced rise in blood pressure and hemorrhage. Prazosin also attenuated the adverse effect noxious stimulation has on long-term recovery. Administration of the adrenergic agonist, norepinephrine, a day after injury induced an increase in blood pressure and disrupted locomotor function, but had little effect on hemorrhage. Further, inducing a rise in blood pressure/flow using norepinephrine undermined long-term recovery and increased tissue loss. Mediational analyses suggest that the pain-induced rise in blood flow may foster hemorrhage after SCI. Increased blood pressure appears to act through an independent process to adversely affect locomotor performance, tissue sparing, and long-term recovery.
Published: 2021

14. A homozygous CAP2 pathogenic variant in a neonate presenting with rapidly progressive cardiomyopathy and nemaline rods

Author: Miguel Reyes-Múgica, Jessica Sebastian, Vivek S. Peche, Jennifer Baker, Shawn C. West, Sharavana Gurunathan, Brian Feingold, Jeffrey Field, Suneeta Madan-Khetarpal, and Hoda Z. Abdel-Hamid
Subjects: Pathology, medicine.medical_specialty, Muscle biopsy, medicine.diagnostic_test, business.industry, Actin monomer binding, Cardiomyopathy, Dilated cardiomyopathy, medicine.disease, Sarcomere, Hypotonia, Nemaline myopathy, Genetics, medicine, medicine.symptom, Nemaline bodies, business, Genetics (clinical)
Abstract: Nemaline Myopathy (NM) is a disorder of skeletal muscles caused by mutations in sarcomere proteins and characterized by accumulation of microscopic rod or thread-like structures (nemaline bodies) in skeletal muscles. Patients diagnosed with both NM and infantile cardiomyopathy are very rare. A male infant presented, within the first few hours of life, with severe dilated cardiomyopathy, biventricular dysfunction and left ventricular noncompaction. A muscle biopsy on the 8th day of life from the right sternocleidomastoid muscle identified nemaline rods. Whole exome sequencing identified a c.1288 delT (homozygous pathogenic variant) in the CAP2 gene (NM_006366), yielding a CAP2 protein (NP_006357.1) with a p.C430fs. Both parents were heterozygous for the same variant but have no history of heart or muscle disease. Analysis of patient derived fibroblasts and cardiomyocytes derived from induced pluripotent stem cells confirmed the p.C430fs mutation (pathogenic variant), which appears to cause loss of both CAP2 protein and mRNA. The CAP2 gene encodes cyclase associated protein 2, an actin monomer binding and filament depolymerizing protein and CAP2 knockout mice develop severe dilated cardiomyopathy and muscle weakness. The patient underwent a heart transplant at 1 year of age. Heart tissue explanted at that time also showed nemaline rods and additionally disintegration of the myofibrillar structure. Other extra cardiac concerns include mild hypotonia, atrophic and widened scarring. This is the first description of a patient presenting with nemaline myopathy associated with a pathogenic variant of CAP2.
Published: 2021

15. Injuries in Elite Men’s Rugby Union: An Updated (2012–2020) Meta-Analysis of 11,620 Match and Training Injuries

Author: Charli Robertson, Keith Stokes, James Brown, Lindsay Starling, Carly McKay, Stephen W. West, and Sean Williams
Subjects: medicine.medical_specialty, Sports medicine, business.industry, Physical Therapy, Sports Therapy and Rehabilitation, medicine.disease, Confidence interval, symbols.namesake, Meta-analysis, Injury data, Concussion, Elite, Injury incidence, symbols, Physical therapy, Medicine, Orthopedics and Sports Medicine, Poisson regression, business
Abstract: Background The most recent meta-analytic review of injuries in elite senior men’s Rugby Union was published in 2013. The demands of the game at the elite level are continually changing alongside law amendments and developments in player preparation. As such, an updated meta-analysis of injury data in this setting is necessary. Objective To meta-analyse time-loss injury data in elite senior men’s Rugby Union between 2012 and 2020. Methods Electronic databases were searched using the keywords ‘rugby’ and ‘inj*’. Nineteen studies met the inclusion criteria. Injury incidence rate data were modelled using a mixed-effects Poisson regression model. Days missed data were modelled using a general linear mixed model. Results The included data encompassed a total of 8819 match injuries and 2801 training injuries. The overall incidence rate of injuries in matches was 91 per 1000 h (95% confidence interval (CI) 77–106). The estimated mean days missed per match injury was 27 days (95% CI 23–32). The overall incidence rate of match concussions was 12 per 1000 h (95% CI 9–15). The overall incidence rate of training injuries was 2.8 per 1000 h (95% CI 1.9–4.0). Playing level was not a significant effect modifier for any outcome. Conclusions The injury incidence rate and mean days missed per injury in the present meta-analysis were higher, but statistically equivalent to, the 2013 meta-analysis (81 per 1000 h and 20 days, respectively). The injury incidence rate for match injuries in elite senior men’s Rugby Union is high in comparison to most team sports, though the training injury incidence rate compares favourably. The tackle event and concussion injuries should continue to be the focus of future preventative efforts.
Published: 2021

16. A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients

Author: Valentina Escott-Price, Jeremy Peter Cheadle, Victoria Gray, Christopher Wills, Yazhou He, Malcolm G. Dunlop, Daniel D. Buchanan, Steve Gallinger, Tim Maughan, Richard Kaplan, Katie Watts, Polly A. Newcomb, Philip J. Law, Matthew G. Summers, Steven R. Alberts, Amanda I. Phipps, Andrew T. Chan, Richard S. Houlston, Qian Shi, Loic Le Marchand, Ulrike Peters, Hannah West, Yi Lin, Nada Al-Tassan, and Rish K. Pai
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Receptor, ErbB-4, Genotype, Colorectal cancer, Single-nucleotide polymorphism, Genome-wide association study, Adenocarcinoma, Polymorphism, Single Nucleotide, Article, Internal medicine, Biomarkers, Tumor, medicine, Humans, SNP, Genetic association, business.industry, Hazard ratio, medicine.disease, Confidence interval, Clinical trial, Colorectal Neoplasms, business, Genome-Wide Association Study
Abstract: BACKGROUND: While genome-wide association studies (GWAS) have identified germline variants influencing the risk of developing colorectal cancer (CRC), there has been limited examination of the possible role of inherited variation as a determinant of patient outcome. PATIENTS AND METHODS: We performed a GWAS for overall survival (OS) in 1926 patients with advanced CRC from the COIN and COIN-B clinical trials. For single nucleotide polymorphisms (SNPs) showing an association with OS (P < 1.0 × 10(−5)), we conducted sensitivity analyses based on the time from diagnosis to death and sought independent replications in 5675 patients from the Study of Colorectal Cancer in Scotland (SOCCS) and 16,964 patients from the International Survival Analysis in Colorectal cancer Consortium (ISACC). We analysed the Human Protein Atlas to determine if ERBB4 expression was associated with survival in 438 patients with colon adenocarcinomas. RESULTS: The most significant SNP associated with OS was rs79612564 in ERBB4 (hazard ratio [HR] = 1.24, 95% confidence interval [CI] = 1.16–1.32, P = 1.9 × 10(−7)). SNPs at 17 loci had suggestive associations for OS and all had similar effects on the time from diagnosis to death. No lead SNPs were independently replicated in the meta-analysis of all patients from SOCCS and ISACC. However, rs79612564 was significant in stage-IV patients from SOCCS (P = 2.1 × 10(−2)) but not ISACC (P = 0.89) and SOCCS combined with COIN and COIN-B attained genome-wide significance (P = 1.7 × 10(−8)). Patients with high ERBB4 expression in their colon adenocarcinomas had worse survival (HR = 1.50, 95% CI = 1.1–1.9, P = 4.6 × 10(−2)). CONCLUSIONS: Genetic and expression data support a potential role for rs79612564 in the receptor tyrosine kinase ERBB4 as a predictive biomarker of survival.
Published: 2021

17. Radiation therapist‐led telephone follow‐up: identifying patients who require post‐treatment care

Author: Katrina West, Susan Prosser, Rachael Beldham-Collins, Jill Harris, Shamira Cross, and Fadila Najem
Subjects: medicine.medical_specialty, Coping (psychology), medicine.medical_treatment, R895-920, radiation therapy, 030218 nuclear medicine & medical imaging, Cohort Studies, 03 medical and health sciences, Medical physics. Medical radiology. Nuclear medicine, 0302 clinical medicine, side effects and telephone follow‐up, medicine, Humans, Radiology, Nuclear Medicine and imaging, Head and neck, Point of care, Cancer, Radiological and Ultrasound Technology, business.industry, Radiation Therapist, Head and neck cancer, patient care, Original Articles, medicine.disease, Telephone, Radiation therapy, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Cohort, Physical therapy, Original Article, Post treatment, business
Abstract: Introduction Radiation therapists implemented telephone follow‐up (TFU) in 2015 as an additional point of care post‐treatment. The purpose of this study was to determine whether TFU identified patients who required additional post‐treatment care before the next scheduled review. Methods Between January 2015 and July 2016, all patients who were prescribed curative intent treatment aged 18 years or over were called 10 days post‐radiation therapy (RT). Eight questions were developed and included asking patients how they were coping, if their side effects were improving, if they needed to contact the hospital and if more dressings were required. Patients who could not be contacted after two attempts were excluded from the study. Microsoft Excel and Statistical Package for Social Sciences (SPSS) were used to analyse the responses. Results Data were collected from 850 patients. A total of 28/846 (3%) of patients reported they were not coping after RT, with 26/830 (3%) reporting their side effects were getting worse. A total of 97/826 (12%) of patients felt they needed to contact the hospital because they were unwell. This study identified 104/677 (15%) of patients who responded required more dressings, with 67/104 (65.7%) and 10/104 (9.8%) of this cohort identified in the breast, and head and neck groups, respectively. Conclusion Radiation therapist‐led TFU has shown to be beneficial in identifying a small cohort of breast and head and neck cancer patients who required additional care post‐radiation treatment., RT‐led TFU effectively identified patients who required additional post‐treatment care. The information gained identified patients in need of assistance prior to scheduled medical follow‐up and allowed for timely support and advice to be given. Additional research is needed to determine the level of psychosocial support required by these patients
Published: 2021

18. Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic

Author: Glasbey, James C, Omar, Omar, Nepogodiev, Dmitri, Minaya-Bravo, Ana, Bankhead-Kendall, Brittany Kay, Fiore, Marco, Futaba, Kaori, Gabre-Kidan, Alodia, Gujjuri, Rohan R, Isik, Arda, Kaafarani, Haytham MA, Kamarajah, Sivesh K, Li, Elizabeth, Loeffler, Markus W, McLean, Kenneth A, Outani, Oumaima, Ntirenganya, Faustin, Satoi, Sohei, Shaw, Richard, Simoes, Joana FF, Stewart, Grant D, Tabiri, Stephen, Trout, Isobel M, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Venn, Mary L, Wilkin, Richard JW, Bhangu, Aneel, Smart, Neil J, Gallo, Gaetano, Moug, Susan, Pata, Francesco, Pockney, Peter, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Griffiths, Ewen A, Evans, Richard PT, Townend, Philip, Roberts, Keith, McKay, Siobhan, Isaac, John, Edwards, John, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Hutchinson, Peter, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Biel, Juan Rey, Batstone, Martin, Ganly, Ian, Vidya, Raghavan, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Sundar, Sudha, Fotopoulou, Christina, Leung, Elaine, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Rajkumar, Shylasree TS, Ng, Joe, Fujiwara, Keiiji, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, Jose, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Ghosh, Dhruv, Gomes, Gustavo Mendonca Ataide, Grecinos, Gustavo, Grundl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jonker, Pascal, Keller, Debby, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Loffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Roslani, April C, Rutegard, Martin, Segura-Sampedro, Juan Jose, Santos, Irene, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Allemand, C, Boccalatte, L, Figari, M, Lamm, M, Larranaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Alurralde, C, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, Garcia, JS, Garcia, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Lam, YH, Ong, BS, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Wright, G, Lanner, M, Koenigsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Oefner, D, Tsibulak, I, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Oehlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St John, S, Walkes, K, Flamey, N, Pattyn, P, Oosterlinck, W, Van den Eynde, J, Van den Eynde, R, Gatti, A, Nardi, C, Oliva, R, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, Terra, RM, Sokolov, M, Kidane, B, Srinathan, S, Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Dumitra, S, Kouyoumdjian, A, Johnston, B, Russell, C, Demyttenaere, S, Garfinkle, R, Abou-Khalil, J, Nessim, C, Stevenson, J, Heredia, F, Almeciga, A, Fletcher, A, Merchan, A, Puentes, LO, Mendoza Quevedo, J, Bacic, G, Karlovic, D, Krsul, D, Zelic, M, Luksic, I, Mamic, M, Bakmaz, B, Coza, I, Dijan, E, Katusic, Z, Mihanovic, J, Rakvin, I, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Szubota, I, Zatecky, J, Javurkova, V, Klat, J, Avlund, T, Christensen, P, Harbjerg, JL, Iversen, LH, Kjaer, DW, Kristensen, HO, Mekhael, M, Ebbehoj, AL, Krarup, P, Schlesinger, N, Smith, H, Abdelsamed, A, Azzam, AY, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, Abosamak, NE, 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H., Abdelkarem, M. M., Alaa, S., Ali, A. K., Ayman, A., Azizeldine, M. G., Elkhayat, H., Melghazaly, S., Monib, F. A., Nageh, M. A., Saad, M. M., Salah, M., Shahine, M., Yousof, E. A., Youssef, A., Eldaly, A., Elfiky, M., Nabil, A., Amira, G., Sallam, I., Sherief, M., Sherif, A., Abdelrahman, A., Aboulkassem, H., Ghaly, G., Hamdy, R., Morsi, A., Sherif, G., Abdeldayem, H., Abdelkader, S. I., Balabel, M., Fayed, Y., Sherif, A. E., Bekele, D., Kauppila, J., Sarjanoja, E., Helminen, O., Huhta, H., Kauppila, J. H., Beyrne, C., Jouffret, L., Lugans, L., Marie-Macron, L., Chouillard, E., De, S. B., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Testelin, S., Boucher, S., Breheret, R., Gueutier, A., Kahn, A., Kun-Darbois, J., Barrabe, A., Lakkis, Z., Louvrier, A., Manfredelli, S., Mathieu, P., Chebaro, A., Drubay, V., El, A. M., Eveno, C., Lecolle, K., Legault, G., Martin, L., Piessen, G., Pruvot, F. 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J., Gillen, K., Hasenburg, A., Krajnak, S., Linz, V., Schwab, R., Angelou, K., Haidopoulos, D., Rodolakis, A., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Fragulidis, G., Gklavas, A., Konstadoulakis, M., Memos, N., Papaconstantinou, I., Polydorou, A., Theodosopoulos, T., Vezakis, A., Antonopoulou, M. I., Manatakis, D. K., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Tsaousis, V., Vassiliu, P., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Baxevanidou, K., Bouliaris, K., Chatzikomnitsa, P., Efthimiou, M., Giaglaras, A., Kalfountzos, C., Koukoulis, G., Ntziovara, A. 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T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone, F. N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De, P. G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni', A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Capizzi, V., Cioffi, S. P. B., Citterio, D., Comini, L. 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T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De, N. P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De, C. E., De, I. P., Dondi, G., Frio, F., Jovine, E., Mineo, B. F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di, M. G. 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I., Salamah, A., Salem, M., Shuwayyah, A., Abdulwahed, E., Alshareea, E., Aribi, N., Aribi, S., Biala, M., Ghamgh, R., Morgom, M., Aldayri, Z., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevicius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Ong, E. C., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin, S. N., Hayati, F., Jayasilan, J., Sriram, R. K., Subramaniam, S., Che, J. A., Hussain, A. H., Mohamed, S. A. S., Mohdyunus, M. F., Soh, J. Y., Wong, M. P. K., Zakaria, A. D., Zakaria, Z., Fadzli, A., Fathi, N. Q., Koh, P. S., Liew, Y. T., Tang, C. Y., Teoh, L. Y., Wong, W. J., Yahaya, A. S., Alvarez, M. R., Arrangoiz, R., Cordera, F., De, L. R. A. M., Gomez-Pedraza, A., Hernandez, R., Maffuz-Aziz, A., Posada, J. A., Becerra, G. F. C., Alfaro-Goldaracena, A., Buerba, G. A., Castillejos-Molina, R. A., Chan, C., Dominguez-Rosado, I., Medina-Franco, H., Mercado, M. 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Saifeldin H., Saleh M.M.E.M., Samih A., Samir A.A., Shehata S., Shenit K., Attia D., Kamal N., Osman N., Abbas A.M., Abd E.H., Abdelkarem M.M., Alaa S., Ali A.K., Ayman A., Azizeldine M.G., Elkhayat H., Melghazaly S., Monib F.A., Nageh M.A., Saad M.M., Salah M., Shahine M., Yousof E.A., Youssef A., Eldaly A., Elfiky M., Nabil A., Amira G., Sallam I., Sherief M., Sherif A., Abdelrahman A., Aboulkassem H., Ghaly G., Hamdy R., Morsi A., Sherif G., Abdeldayem H., Abdelkader S.I., Balabel M., Fayed Y., Sherif A.E., Bekele D., Kauppila J., Sarjanoja E., Helminen O., Huhta H., Kauppila J.H., Beyrne C., Jouffret L., Lugans L., Marie-Macron L., Chouillard E., De S.B., Bettoni J., Dakpe S., Devauchelle B., Lavagen N., Testelin S., Boucher S., Breheret R., Gueutier A., Kahn A., Kun-Darbois J., Barrabe A., Lakkis Z., Louvrier A., Manfredelli S., Mathieu P., Chebaro A., Drubay V., El A.M., Eveno C., Lecolle K., Legault G., Martin L., Piessen G., Pruvot F.R., Truant S., Zerbib P., Ballouhey Q., 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S., Kleeff J., Lorenz K., Michalski C., Ronellenfitsch U., Schneider R., Bertolani E., Konigsrainer A., Quante M., Steidle C., Uberruck L., Yurttas C., Betz C.S., Bewarder J., Bottcher A., Burg S., Busch C., Gosau M., Heuer A., Izbicki J., Klatte T.O., Koenig D., Moeckelmann N., Nitschke C., Priemel M., Smeets R., Speth U., Thole S., Uzunoglu F.G., Vollkommer T., Zeller N., Battista M.J., Gillen K., Hasenburg A., Krajnak S., Linz V., Schwab R., Angelou K., Haidopoulos D., Rodolakis A., Antonakis P., Bramis K., Chardalias L., Contis I., Dafnios N., Dellaportas D., Fragulidis G., Gklavas A., Konstadoulakis M., Memos N., Papaconstantinou I., Polydorou A., Theodosopoulos T., Vezakis A., Antonopoulou M.I., Manatakis D.K., Tasis N., Arkadopoulos N., Danias N., Economopoulou P., Kokoropoulos P., Larentzakis A., Michalopoulos N., Selmani J., Sidiropoulos T., Tsaousis V., Vassiliu P., Bouchagier K., Klimopoulos S., Paspaliari D., Stylianidis G., Baxevanidou K., Bouliaris K., Chatzikomnitsa P., 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Pickett L., Akmenkalne L., Byrne J., Corrigan M., Cullinane C., Daly A., Fleming C., Jordan P., Killeen S., Lynch N., McCarthy A., Mustafa H., O'Brien S., O'Leary P., Syed W.A.S., Vernon L., Callanan D., Huang L., Ionescu A., Sheahan P., Balasubramanian I., Boland M., Conlon K., Evoy D., Fearon N., Gallagher T., Geraghty J., Heneghan H., Kennedy N., Maguire D., McCartan D., McDermott E.W., Prichard R.S., Winter D., Alazawi D., Barry C., Boyle T., Butt W., Connolly E.M., Donlon N., Donohue C., Fahey B.A., Farrell R., Fitzgerald C., Kinsella J., Larkin J.O., Lennon P., Maguire P.J., McCormick P., Mehigan B.J., Mohan H., Nugent T., O'Sullivan H., Ravi N., Reynolds J.V., Rogers A., Shokuhi P., Smith J., Smith L.A., Timon C., Bashir Y., Bass G., Connelly T., Creavin B., Earley H., Elliott J.A., Gillis A., Kavanagh D., Neary P., O'Riordan J., Reynolds I.S., Rice D., Ridgway P., Umair M., Whelan M., Carroll P., Collins C., Corless K., Finnegan L., Fowler A., Hogan A., Kerin M., Lowery A., McAnena P., McKevitt K., Nizami K., Ryan E., Samy A., Coffey J.C., Cunningham R., Devine M., Nally D., Peirce C., Tormey S., Hardy N., O'Malley S., Ryan M., MacIna S., Mariani N.M., Opocher E., Pisani C.A., Ferrari F., Odicino F., Sartori E., Cotsoglou C., Granieri S., Bianco F., Camillo' A., Colledan M., Tornese S., Zambelli M.F., Bissolotti G., Fusetti S., Lemma F., Marino M.V., Mirabella A., Vaccarella G., Agostini C., Alemanno G., Bartolini I., Bergamini C., Bruscino A., Checcucci C., De V.R., Di B.A., Fambrini M., Fortuna L., Maltinti G., Muiesan P., Petraglia F., Prosperi P., Ringressi M.N., Risaliti M., Sorbi F., Taddei A., Tucci R., Bassi C., Bortolasi L., Campagnaro T., Casetti L., De P.M., Esposito A., Fontana M., Guglielmi A., Landoni L., Malleo G., Marchegiani G., Nobile S., Paiella S., Pedrazzani C., Rattizzato S., Ruzzenente A., Salvia R., Turri G., Tuveri M., Bellora P., D'Aloisio G., Ferrari M., Francone E., Gentilli S., Nikaj H., Bianchini M., Chiarugi M., Coccolini F., Di F.G., Furbetta N., Gianardi D., Guadagni S., Morelli L., Palmeri M., Tartaglia D., Anania G., Carcoforo P., Chiozza M., De T.A., Koleva R.M., Portinari M., Sibilla M.G., Urbani A., Fabbri N., Feo C.V., Gennari S., Parini S., Righini E., Ampollini L., Bellanti L., Bergonzani M., Bertoli G., Bocchialini G., D'Angelo G., Lanfranco D., Musini L., Poli T., Santoro G.P., Varazzani A., Aguzzoli L., Borgonovo G., Castro R.C., Coiro S., Falco G., Mandato V.D., Mastrofilippo V., Montella M.T., Annessi V., Zizzo M., Grossi U., Novello S., Romano M., Rossi S., Zanus G., Esposito G., Frongia F., Pisanu A., Podda M., Belluco C., Lauretta A., Montori G., Moras L., Olivieri M., Bussu F., Carta A.G., Cossu M.L., Cottu P., Fancellu A., Feo C.F., Ginesu G.C., Giuliani G., Madonia M., Perra T., Piras A., Porcu A., Rizzo D., Scanu A.M., Tedde A., Tedde M., Delrio P., Rega D., Badalamenti G., Campisi G., Cordova A., Franza M., Maniaci G., Rinaldi G., Toia F., Calabro M., Farnesi F., Lunghi E.G., Muratore A., Pipitone F.N.S., Bambina F., D'Andrea G., Familiari P., Picotti V., De P.G., Luglio G., Pagano G., Tropeano F.P., Baldari L., Beltramini G.A., Boni L., Cassinotti E., Gianni' A., Pignataro L., Torretta S., Abatini C., Baia M., Biasoni D., Bogani G., Cadenelli P., Capizzi V., Cioffi S.P.B., Citterio D., Comini L.V., Cosimelli M., Folli S., Gennaro M., Giannini L., Zweroncy A., Guaglio M., MacChi A., Martinelli F., Mazzaferro V., Mosca A., Pasquali S., Piazza C., Raspagliesi F., Rolli L., Salvioni R., Sarpietro G., Sarre C., Sorrentino L., Agnes A., Alfieri S., Belia F., Biondi A., Cozza V., D'Amore A., D'Ugo D., De S.V., Gasparini G., Gordini L., Litta F., Lombardi C.P., Lorenzon L., Marra A.A., Marzi F., Moro A., Parello A., Perrone E., Ratto C., Rosa F., Saponaro G., Scambia G., Scrima O., Sganga G., Tudisco R., Belli A., Granata V., Izzo F., Palaia R., Patrone R., Carrano F.M., Carvello M.M., De V.A., Di C.F., Ferreli F., Gaino F., Mercante G., Rossi V., Spriano G., Donati D.M., Frisoni T., Palmerini E., Aprile A., Barra F., Batistotti P., Ferrero S., Fregatti P., Scabini S., Sparavigna M., Asti E., Bernardi D., Bonavina L., Lovece A., Adamoli L., Ansarin M., Cenciarelli S., Chu F., De B.R., Fumagalliromario U., Mastrilli F., Pietrobon G., Tagliabue M., Badellino E., Ferrero A., Massobrio R., De M.G.A., Federico P., Maida P., Marra E., Marte G., Petrillo A., Tammaro T., Tufo A., Berselli M., Borroni G., Cocozza E., Conti L., Desio M., Livraghi L., Quintodei V., Rizzi A., Zullo A., Baldi C., Corbellini C., Sampietro G.M., Cellerino P., Baldini E., Capelli P., Isolani S.M., Ribolla M., Bondurri A., Colombo F., Ferrario L., Guerci C., Maffioli A., Armao T., Ballabio M., Bisagni P., Gagliano A., Longhi M., Madonini M., Pizzini P., Baietti A.M., Biasini M., Maremonti P., Neri F., Prucher G.M., Ricci S., Ruggiero F., Zarabini A.G., Barmasse R., Mochet S., Usai A., Incollingo P., Mancini S., Marino C.L., Sagnotta A., Fruscio R., Grassi T., Nespoli L.C., Tamini N., Anastasi A., Bartalucci B., Bellacci A., Canonico G., Capezzuoli L., Di M.C., Ipponi P., Linari C., Montelatici M., Nelli T., Spagni G., Tirloni L., Vitali A., Abate E., Casati M., Casiraghi T., Laface L., Schiavo M., Arminio A., Cotoia A., Lizzi V., Vovola F., Vergari R., D'Ugo S., Depalma N., Spampinato M.G., Bartolucci P., Brachini G., Bruzzaniti P., Chiappini A., Chiarella V., Ciccarone F., Cicerchia P.M., Cirillo B., De T.G., Fiori E., Fonsi G.B., Franco G., Frati A., Giugliano M., Iannone I., La T.F., Lapolla P., Leonardo C., Marruzzo G., Meneghini S., Mingoli A., Ribuffo D., Salvati M., Santoro A., Sapienza P., Scafa A.K., Simonelli L., Zambon M., Capolupo G.T., Carannante F., Caricato M., Masciana G., Mazzotta E., Gattolin A., Migliore M., Rimonda R., Sasia D., Travaglio E., Cervellera M., Gori A., Sartarelli L., Tonini V., Giacometti M., Zonta S., Chessa A., Fiorini A., Norcini C., Colletti G., Confalonieri M., Costanzi A., Frattaruolo C., Mari G., Monteleone M., Bandiera A., Bocciolone L., Bonavina G., Candiani M., Candotti G., De N.P., Gagliardi F., Medone M., Mortini P., Negri G., Parise P., Piloni M., Sileri P., Vignali A., Belvedere A., Bernante P., Bertoglio P., Boussedra S., Brunocilla E., Cipriani R., Cisternino G., De C.E., De I.P., Dondi G., Frio F., Jovine E., Mineo B.F., Neri J., Parlanti D., Perrone A.M., Pezzuto A.P., Pignatti M., Pinto V., Poggioli G., Ravaioli M., Rottoli M., Schiavina R., Serenari M., Serra M., Solli P., Taffurelli M., Tanzanu M., Tesei M., Violante T., Zanotti S., Borghi F., Cianflocca D., Di M.G.S., Donati D., Gelarda E., Geretto P., Giraudo G., Giuffrida M.C., Marano A., Palagi S., Pellegrino L., Peluso C., Testa V., Agresta F., Prando D., Zese M., Aquila F., Gambacciani C., Pieri F., Santonocito O.S., Armatura G., Bertelli G., Frena A., Marinello P., Notte F., Patauner S., Scotton G., Fulginiti S.F., Sammarco G., Vescio G., Balercia P., Catarzi L., Consorti G., Di M.F., Fontana T., Daiko H., Ishikawa M., Ishiyama K., Iwata S., Kanematsu K., Kanemitsu Y., Kato T., Kawai A., Kobayashi E., Kobayashi K.M., Moritani K., Nakatani F., Oguma J., Tanase Y., Uno M., Al A.M., Ayasra Y., Qasem A., Abu Z.F.J., Fahmawee T., Hmedat A., Ibrahim A., Obeidat K., Abdel A.S., Abdel J.R., Abouchaar M.K., Al-Masri M., Al-Najjar H., Alawneh F., Alsaraireh O., Elayyan M., Ghanem R., Lataifeh I., Alkadeeki G.Z., Al M.F.S., Aldokali N., Senossi O., Subhi M.T., Burgan D., Kamoka E., Kilani A.I., Salamah A., Salem M., Shuwayyah A., Abdulwahed E., Alshareea E., Aribi N., Aribi S., Biala M., Ghamgh R., Morgom M., Aldayri Z., Ellojli I., Kredan A., Bradulskis S., Dainius E., Kubiliute E., Kutkevicius J., Parseliunas A., Subocius A., Venskutonis D., Rasoaherinomenjanahary F., Razafindrahita J.B., Samison L.H., Ong E.C., Hamdan K.H., Ibrahim M.R., Tan J.A., Thanapal M.R., Amin S.N., Hayati F., Jayasilan J., Sriram R.K., Subramaniam S., Che J.A., Hussain A.H., Mohamed S.A.S., Mohdyunus M.F., Soh J.Y., Wong M.P.K., Zakaria A.D., Zakaria Z., Fadzli A., Fathi N.Q., Koh P.S., Liew Y.T., Tang C.Y., Teoh L.Y., Wong W.J., Yahaya A.S., Alvarez M.R., Arrangoiz R., Cordera F., De L.R.A.M., Gomez-Pedraza A., Hernandez R., Maffuz-Aziz A., Posada J.A., Becerra G.F.C., Alfaro-Goldaracena A., Buerba G.A., Castillejos-Molina R.A., Chan C., Dominguez-Rosado I., Medina-Franco H., Mercado M.A., Oropeza-Aguilar M., Pena G.P.E., Posadas-Trujillo O.E., Rodriguez-Covarrubias F., Salgado-Nesme N., Vilatoba M., Arkha Y., Bechri H., El O.A., Oudrhiri M.Y., Derkaouihassani F., El A.N., Amrani L., Belkhadir Z.H., Benkabbou A., Chakib O., El A.B., El B.Y., Essangri H., Ghannam A., Majbar A.M., Mohsine R., Souadka A., Hompes R., Meima-Van P.E.M., Pronk A.J.M., Sharabiany S., Grotenhuis B., Hartveld L., Reijers S., Van H.W., Baaij J., Bolster-Van E.M., De G.M., Sloothaak D., Van D.P., Posma-Bouman L., Derksen T., Franken J., Oosterling S., Konsten J., Van H.M., Fidelis L., Sholadoye T.T., Tolani M.A., Olaogun J., Egbuchulem I.K., Lawal T.A., Ogundoyin O., Olulana D.I., Abdur-Rahman L., Adeyeye A., Aremu I., Bello J., Olasehinde O., Popoola A., Massoud J., Massoud R., Sorour T.M., Jamal A., Kerawala A.A., Memon A.S., Nafees A.R., Rai L., Ayub B., Hassan N., Martins R.S., Ramesh P., Butt U., Kashif M., Khan W.H., Umar M., Warisfarooka M., Wasim T., Ayubi A., Rashid I., Waqar S.H., Falcon G.M., Robles R., Jocson R., Teh C., Bobinski M., Kotarski J., Rasoul-Pelinska K., Azevedo C., MacHado D., Mendes F., De S.X., Fernandes U., Ferreira C., Guidi G., Leal C., Marcal A., Marques R., Martins D., Melo A., Tenreiro N., Vaz P.R., Vieira B., Almeida J.I., Correia D.S.T., Costa M.J.M.A., Fernandes V., Ferraz I., Gil C.G., Lima D.S.C., Lopes L., MacHado N., Marialva J., Nunes C.M., Pedro J., Pereira C., Reis R., Ribeiro A., Santos R., Saraiva P., Silva R., Tavares F., Teixeira M., Almeida A.C., Amaral M.J., Andrade R., Athaydenemesio R., Breda D., Camacho C., Canhoto C., Colino M., Correia S., Costa M., De B.J., De O.L.A., Duque M., Garrido S., Guerreiro P., Guimaraes A., Lazaro A., Lopes C., Martins R., Nogueira O., Oliveira A., Oliveira J.M., Rodrigues M., Ruivo A., Santos E., Silva M., Simoes J., Valente D.C.A., Almeida A., Cavaleiro S., Devezas V., Faria C.S., Jacome F., Magalhaes M.M., Nogueiro J., Pereira A., Pereira-Neves A., Pina-Vaz T., Santos-Sousa H., Silveira H., Vaz S., Vieira P., Gomes D.C.A., Lobo A.I., Pinto J., Tojal A., Cardoso N., Cardoso P., Domingues J.C., Henriques P., Manso M.I., Martins D.S.G., Morais H., Pereira R., Revez T., Ribeiro R., Ribeiro V.I., Soares A., Sousa S., Teixeira J., Amorim E., Baptista V.H., Dias B., Fazenda A., Melo N.J.P., Policarpo F., Sampaio D.N.G.M.I., Veiga D., Andrade A.K., Bandovas J.P., Borges N., Branquinho A., Chumbinho B., Correia J., Fidalgo H., Figueiredo D.B.I., Frade S., Gomes J., MacIel J., Pina S., Rodrigues A., Silva N., Silveira N.I., Sousa R., Ascensao J., Azevedo P., Costeira B., Cunha C., Garrido R., Gomes H., Lourenco I., Mendinhos G., Miranda P., Nobre P.A., Peralta F.M., Ribeiro J., Rio R.L., Sousa F.M., Galvao D., Soares A.C., Vieira A., Patricio B., Santos P.M.D.D., Vieira P.L.A.C., Cunha R., Faustino A., Freitas A., Martins A.B., Mendes J.R., Parreira R., Rosa J., Teves M., Abreu D.S.A., Claro M., Costa S.D., Deus A.C., Grilo J.V., Borges F., Corte R.J., Henriques S., Lima M.J., Matos C.P., Brito D.S.F., Caiado A., Fonseca F., Angelo M., Baiao J.M., Martins J.D., Vieira C.T., Messias J., Millan A., Salgado I., Santos P., Baia C., Canotilho R., Correia A.M., Ferreira P.A.P., Peyroteo M., Videira J.F., Bezede C., Chitul A., Ciofic E., Cristian D., Grama F., Pirtea L., Secosan C., Bonci E., Gata V., Titu S., Ginghina O., Iordache N., Iosifescu R.V., Kazachenko E., Markaryan D., Rodimov S., Tsarkov P., Tulina I., Litvina Y., Provozina A., Agapov M., Galliamov E., Kakotkin V., Kubyshkin V., Alshahrani M., Alsharif F., Eskander M., Al R.R., Majrashi S., Mashat A., Akeel N., Alharthi M., Aljiffry M., Basendowah M., Farsi A., Ghunaim M., Khoja A., Maghrabi A., Malibary N., Nassif M., Nawawi A., Saleem A., Samkari A., Trabulsi N., Al A.S., Alghamdi M., Alnumani T., Nasser M., Said B.A., Alhefdhi A., Almalik O., Alomair A., Alotaibi N., Alresaini F., Alsalamah R., Alsobhi S., Mahasin Z., Othman E., Velagapudi S., Ghedan S., Alharthi R., Awad S., Sharara M., Abdelrahman S., Althobaiti W., Al H.H., Alkarak S., Alqannas M., Alyami M., Alzamanan M., Cortes G.D., Elawad A., Alaamer O., Alriyees L., Alselaim N., Abdulkareem A., Ajlan A., Akkour K., Al-Habib A., Al-Khayal K., Alatar A., Alburakan A., Alhalal H., Alhassan B., Alhassan N., Alobeed O., Alsaif A., Alsaif F., Alshammari S., Alshaygy I., Barry M., Bin N.A., Bin T.T., Bokhari A., Elwatidy S., Helmi H., Madkhali A., Nouh T., Rabah P.D., Zubaidi A., Paunovic I., Slijepcevic N., Aleksic L., Antic A., Barisic G., Ceranic M., Galun D., Grubac Z., Jelenkovic J., Kecmanovic D., Kmezic S., Knezevic D., Krivokapic Z., Latincic S., Markovic V., Matic S., Miladinov M., Pavlov M., Pejovic I., Tadic B., Vasljevic J., Velickovic D., Zivanovic M., Perovic M., Srbinovic L., Andrijasevic S., Bozanovic T., Cerovic P.R., Dokic M., Janjic T., Jeremic K., Kadija S., Ladjeviclikic I., Mirkovic L., Pantovic S., Pilic I., Radojevic M., Stefanovic A., Vidakovic S., Vilendecic Z., Antic S., Dunderovic D., Jelovac D., Jezdic Z., Konstantinovic V., Kotlar B., Kuzmanovic C., Lazic M., Petrovic M., Popovic F., Pucar A., Romic M., Sumrak S., Vujanac V., Bascarevic V., Bogdanovic I., Grujicic D., Ilic R., Milicevic M., Milisavljevic F., Miljkovic A., Paunovic A., Scepanovic V., Stanimirovic A., Todorovic M., Jotic A., Milovanovic J., Trivic A., Bumbasirevic U., Dzamic Z., Kajmakovic B., Prijovic N., Zivkovic M., Buta M., Cvetkovic A., Djurisic I., Gacic S., Goran M., Inic Z., Jeftic N., Jevric M., Jokic V., Markovic I., Milanovic M., Nikolic S., Pejnovic L., Savkovic N., Spurnic I., Stevic D., Stojiljkovic D., Vucic N., Zegarac M., Karamarkovic A., Kenic M., Kovacevic B., Krdzic I., Milutinovic V., Chan C.W., Lieske B., Galis B., Simko K., Almgla N., Bernon M., Boutall A., Cairncross L., Herman A., Hilton T., Jonas E., Kloppers C., Malherbe F., Mugla W., Nel D., Rayamajhi S., Van W.T., Vogel J., Castano-Leon A.M., Delgado F.J., Eiriz F.C., Espino S.-I.M., Esteban S.O., Garcia P.D., Gomez P., Jimenez-Roldan L., Lagares A., Moreno-Gomez L., Paredes I., Perez N.A., Sanchez A.G., Santas M., Fernandez R.P., Paniagua G.S.M., Sanchez-Santos R., Vigorita V., Acrich E., Baenasanfeliu E., Barrios O., Golda T., Santanach C., Serrano-Navidad M., Sorribasgrifell M., Vives R.V., Escola D., Jimenez A., Cayetano P.L., Gomez F.L., Artigues E., Bernal-Sprekelsen J.C., Catalabauset J.C., Collera P., Diaz D.G.R., Farre F.R., Flores C.R., Gomez D.C.J., Guardia N., Guariglia C.A., Osorio A., Sanchez J.R., Sanchon L., Soto M.C., Albi M.B., Garcia V.J.E., Alonso-Lamberti L., Assaf M., Baeza P.N., Carabias A., Garcia-Quijada J., Huertas F.M.A., Jimenez M.J., Jimenez V., Jover J.M., Landeoaguero S.A., Leon R., Martin S.M., Perez S.V., Ponce S., Rodriguez J.L., Salazar A., Valle R.A., Aguado H., Aldecoaansorregui I., Bravo I.R., De L.F., Di S.A., Diaz-Feijoo B., Ensenat N.J., Fabregas N., Ferres A., Gil I.B., Gonzalez S.J., Gracia I., Hoyos C.J., Lacy A.M., Langdon C., Momblan D., Morales X., Oleaga L., Otero A., Pedrosa L., Poblete C.J., Reyes F.L., Roldan R.P., Rumia-Arboix J., Tercero-Uribe A.I., Topczewski T.E., Torales J., Torne A., Torne R., Turrado-Rodriguez V., Valero R., Valverde S., Anula R., Cano-Valderrama O., Del C.M.M., Diez-Valladares L., Dominguez I., Dziakova J., Garcia A.M., Garcia R.E., Gomez L.L., Muguerza J.M., Pizarro M.J., Saez C.P., Sanchez D.P.C., Sanchez-Pernaute A., Sanz O.G., Sanz-Lopez R., Torres A., Garces-Albir M., Lopez F., Martin-Arevalo J., Moro-Valdezate D., Pla-Marti V., Beltran D.H.J., De A.A.B., Gomez S.T., Jezieniecki C., Nunez D.B.H., Ortiz D.S.A.F., Romero D.D.A., Ruiz S.M., Trujillo D.J., Vazquez F.A., Lora-Cumplido P., Sosa M.V., Gonzalez-Gonzalez E., Minaya B.A., Alonso D.L.F.N., Cazadorlabat M., Cecchini L., Espinosa C.A., Jimenez T.M., Lopez C.A., Mancebo G., Martorell P., Munarriz M., Grau-Talens E.J., Martin-Perez B., Benavides B.J., Carrasco P.M., Fernandez P.V., Fernandez-Lopez A., Garcia E.D., Garcia P.V., Garcia S.V., Gimenezfrances C., Gonzalez V.F., Gurrea E., Lopez-Morales P., Marco G.A., Martinez A.J., Medina E., Munoz C.J., Parra B.P., Pena R.E., Ramirez F.M., Ruiz-Marin M., Sanchez R.C., Valero S.M., Estaire G.M., Fernandez C.A., Garcia S.E., Jimenez H.E., Martinez-Pinedo C., Munoz-Atienza V., Padilla-Valverde D., Picon R.R., Redondo C.F., Sanchez-Garcia S., Sanchez-Pelaez D., Colombari R.C., Del V.E., Fernandez M., Lozano L.P., Rey V.C., Steiner M.A., Tudela M., Zorrillaortuzar J., Alcaide M.F., Garcia P.J., Troncoso P.P., Mora-Guzman I., Abellan M., Achalandabasoboira M., Jorba R., Membaikuga R., Olona C., Sales M.R., Cavalle B.P., Gavaldapellice M.G.P., Salinas P.J., Aragon A.E., Barbier L., Cajavivancos P., Gainza A., Garcia G.J., Mallabiabarrenaormaechea G., Marin H., Martin P.P., Melchor C.I., Prieto C.M., Rodriguez F.A., Villalabeitiaateca I., De A.O.U., Duran B.M., Fernandez P.F., Ibanez-Aguirre F.J., Sanz L.A., Ugarte-Sierra B., De L.H.R.A., Di M.M., Garcia S.J., Martin-Perez E., Munoz D.N.J., Calvo E.P., Guillamotruano P., Colao G.L., Diaz P.D., Esteban A.E., Galindo J.P., Gutierrez S.M., Hernandez B.M., Serrano G.J., Alonso P.A., Dieguez B., Garcia-Conde M., Hernandez-Garcia M., Losada M., Chiesa-Estomba C.M., Gonzalez G.J., Larruscain E., Sistiaga-Suarez J.A., Alvarez E., Chavarrias N., Frias L., Gegundez S.A., Gortazar S., Gracia M., Guevara J., Hernandez G.A., Loayza A., Maria D.D., Marti C., Melendez M., Moreno-Palacios E., Perez Y., Prieto N.M., Ramos-Martin P., Rubio-Perez I., Saavedra J., Sanchez-Mendez J.I., Siegrist R.J., Urbieta A., Zapardiel I., Cantalejodiaz M., De M.A.M., Duque-Mallen V., Gascon F.I., Gonzalez-Nicolas T.M., Gracia-Roche C., Herrero L.M., Jariod F.U., Lanzon A., Martinez G.A., Matute M., Redondo C., Sanchez F.N., Sanchez-Rubio M., Santero-Ramirez M.S., Saudi S., Simon S.M., Uson-Bouthelier T., Blazquez M.A., Diez A.M., Garcia-Loarte G.E., Garcia-Moreno N.F., Gutierrez C.A., Hernandez P., Lasa I., Mendoza-Moreno F., Morales P.N., Ovejero M.E., Vera M.C., Acebes G.F., Bailon M., Bueno C.A., Choolanibhojwani E., Marcos-Santos P., Miguel T., Pacheco S.D., Perez-Saborido B., Sanchez G.J., Tejero-Pintor F.J., Alconchel F., Conesa A., Gil M.J., Gutierrez F.A., Lopez A.A., Nicolas-Lopez T., Ramirez R.P., Roca C.M., Rodrigues K., Ruiz M.J., Soriano A.I., Cano A., Capitan-Morales L., Cintas C.J., Gomez-Rosado J., Oliva M.F., Perez S.M., Rio L.F., Torres A.C., Valdes-Hernandez J., Cholewa H., Domingo S., Frasson M., Lago V., Marina M.T., Martinez C.C., Sancho-Muriel J., Landaluce-Olavarria A., Lecumberri D., Abad G.A., Abad-Motos A., Martinez-Hurtado E., Ripolles-Melchor J., Ruiz E.A., Cuadrado-Garcia A., Garcia-Sancho T.L., Heras A.J., Mate P., Ortega V.I., Picardo A.L., Rojo L.J., Sanchez C.F., Serralta D.C.D., Anchuelolatorre J., Cagigas F.C., Caina R.R., Gomez R.M., Hernanz F., Jimenofraile J., Martinez-Perez P., Poch C., Santarrufina M.S., Valbuena J.V., Moliner-Sanchez C., Pingarron-Martin L., Rey-Biel J., Ruiz M.I., Blas L.J., Cros B., Escartin J., Garcia E.J., Nogues A., Talal E.-A.I., Yanez C., Cagigal O.E., Cervera I., Diaz P.P., Elena G.D.C.R., Enjuto D., Fernandez B.P., Garces G.R., Gonzalez J., Hernandez I., Herrera-Merino N., Marqueta D.S.M., Martinez P.P., Perez G.M., Ramos B.A., Rodriguez G.L., Bescos C., Brana I., Caimari B., De P.G.-C.A., Duran-Valles F., Espin-Basany E., Giralt L.D.S.J., Pamias J., Prat N., Pujol P.R., Saezbarba M., Arulanantham A., Bandara G.B.K., Jayarajah U., Ravindrakumar S., Rodrigo V.S., Srishankar S., Elbe P., Lindqvist E.K., Taflin H., Alga A., Heinius G., Nordberg M., Pieniowski E., Gkekas I., Lofgren N., Sund M., Arigoni M., Bernasconi M., Christoforidis D., Di G.M., La R.D., Mongelli F., Chevallay M., Dwidar O., Gialamas E., Sauvain M., Klenke F., Kollar A., Kurze C., Bachler T., Crugnale A.S., Giardini M., Guglielmetti L., Peros G., Solimene F., Aghayeva A., Hamzaoglu I., Sahin I., Akaydin E., Aliyeva Z., Aytac E., Baca B., Dulgeroglu O., Ozben V., Ozmen B.B., Uras C., Arikan A.E., Bilgin I.A., Bozkirli B., Ceyhan G.O., Kara H., Karahasanoglu T., Celik H., Meydanli M.M., Akilli H., Ayhan A., Kuscu E., Onan M.A., Akgor U., Dincer H.A., Erol T., Gultekin M., Orhan N., Ozgul N., Salman M.C., Soyak B., Alhamed A., Ergun S., Ozcelik M.F., Sanli A.N., Uludag S.S., Velidedeoglu M., Zengin A.K., Bozkurt M.A., Kara Y., Kocatas A., Cimenoglu B., Demirhan R., Saracoglu K., Azamat I.F., Balik E., Bugra D., Giray B., Kulle C.B., Taskiran C., Vatansever D., Gozal K., Guler S.A., Koken H., Tatar O.C., Utkan N.Z., Yildirim A., Yuksel E., Akin E., Altintoprak F., Bayhan Z., Cakmak G., Capoglu R., Celebi F., Demir H., Dikicier E., Firat N., Gonullu E., Kamburoglu M.B., Kocer B., Kucuk I.F., Mantoglu B., Colak E., Kucuk G.O., Uyanik M.S., Goksoy B., Bozkurt E., Citgez B., Mihmanli M., Tanal M., Yetkin G., Akalin M., Arican C., Avci E.K., Aydin C., Demirliatici S., Emiroglu M., Kaya T., Kebabci E., Kilinc G., Kirmizi Y., Ogucu H., Salimoglu S., Sert I., Tugmen C., Tuncer K., Uslu G., Yesilyurt D., Karaman E., Kolusari A., Yildiz A., Benson O., Lule H., Agilinko J., Ahmeidat A., Barabasz M., Bekheit M., Cheung L.K., Colloc T., Cymes W., Elhusseini M., Gradinariu G., Hannah A., Kamera B.S., Mignot G., Shaikh S., Sharma P., Abu-Nayla I., Agrawal A., Al-Mohammad A., Ali S., Ashcroft J., Azizi A., Baker O., Balakrishnan A., Byrne M., Cotter A., Coughlin P., Davies R.J., Durrani A., Elshaer M., Fordington S., Forouhi P., Georgiades F., Grimes H., Habeeb A., Hudson V., Irune E., Jah A., Khan D.Z., Kyriacou H., Liau S., Luke L., Mahmoud R., Mannion R., Masterson L., Mitrofan C.G., Mohan M., Morris A., Murphy S., O'Neill R., Price S., Pushpa-Rajah J., Raby-Smith W., Ramzi J., Rooney S., Santarius T., Singh A., Tan X.S., Townson A., Tweedle E., Walker C., Waseem S., Yordanov S., Jones T., Kattakayam A., Loh C., Lunevicius R., Pringle S., Schache A., Sheel A., Rossborough C., Angelou D., Choynowski M., McAree B., McCanny A., Neely D., Tutoveanu G., Ahad S., De L.C.M.M., Mosley F., Oktseloglou V., Alanbuki A., Patel M., Shabana A., Perera E., Raveendran D., Ravi-Shankar K., Thiruchelvam J., Arrowsmith L., Campbell W., Grove T., Kontovounisios C., Warren O., Rolland P., Aggarwal A., Brown S., Jelley C., Neal N., Clifford R., Eardley N., Krishnan E., Manu N., Martin E., Roy M.S., Serevina O.L., Smith C., Bordenave M., Houston R., Putnam G., Robson A., Tustin H., Emslie K., Labib P.L., Miller D., Minto G., Natale J., Nwinee H., Panahi P., Rogers L., Abubakar A., Akhter R.M., Ko K.Y.K., O'Brien H., Sasapu K., Woodun H., Inglis R., Ng H.J., De G.R.A., Ghazali N., Lambert J., Markose G., Math S., Sarantitis I., Shrestha D., Sultana A., Taggarsi M., Timbrell S., Vaz O.P., Vitone L., Day A., Dent H., Fahim M., Waheed S., Hunt A., Laskar N., Gupta A., Steinke J., Thrumurthy S., Massie E., McGivern K., Rutherford D., Wilson M., Hardie J., Kazzaz S., Handa S., Kaushal M., Kler A., Patel P., Redfern J., Tezas S., Aawsaj Y., Amonkar S., Blackwell L., Blake D., Carter J., Emerson H., Fisher A., Katory M., Korompelis P., McCormick W., Mustafa A., Pearce L., Ratnavelu N., Reehal R., Kretzmer L., Lalou L., Manku B., Parwaiz I., Stafford J., Abdelkarim M., Asqalan A., Gala T., Ibrahim S., Maw A., Mithany R., Morgan R., Sundaram V.G., Ang K., Chowdhry M.F., Mohammad A., Nakas A., Rathinam S., Boal M., Brown O., Dwerryhouse S., Higgs S., Boyd E., Irvine V., Kirk A., Bakolas G., Boulton A., Chandock A., Kumar M., Agoston P., Bille A., Challacombe B., Fraser S., Harrison-Phipps K., King J., Mehra G., Mills L., Najdy M., Nath R., Okiror L., Pilling J., Rizzo V., Routledge T., Sayasneh A., Stroman L., Wali A., Fehervari M., Habib N., Hamrang-Yousefi S., Jawad Z., Jiao L., Pai M., Ploski J., Rajagopal P., Saso S., Sodergren M., Spalding D., Laws S., Hardie C., McNaught C., Alam R., Budacan A., Cahill J., Kalkat M., Karandikar S., Kenyon L., Naumann D., Ayorinde J., Chase T., Cuming T., Ghanbari A., Humphreys L., Tayeh S., Aboelkassem I.A., Bichoo R., Cao H., Chai A.K.W., Choudhury J., Evans C., Fitzjohn H., Ikram H., Langstroth M., Loubani M., McMillan A., Nazir S., Qadri S.S.A., Robinson A., Ross E., Sehgal T., Dixon J., Dunning J., Freystaetter K., Jha M., Lester S., Madhavan A., Thulasiraman S.V., Viswanath Y., Curl-Roper T., Delimpalta C., Liao C.C.L., Velchuru V., Westwood E., Belcher E., Bond-Smith G., Chidambaram S., Fasanmade K., Fraser L., Fu H., Ganau M., Gore S., Graystone J., Jeyaretna D., Khatkar H., Lami M., Maher M., Mastoridis S., Mihai R., Piper R., Prabhu S., Risk O.B.F., Selbong U., Shah K., Smillie R., Soleymanimajd H., Sravanam S., Stavroulias D., Tebala G.D., Vatish M., Verberne C., Wallwork K., Winter S., Bhatti M.I., Boyd-Carson H., Elsey E., Gemmill E., Herrod P., Jibreel M., Lenzi E., Saafan T., Sapre D., Sian T., Watson N., Athanasiou A., Bourke G., Bradshaw L., Coe P., Costigan F., Elkadi H., Johnstone J., Kanatas A., Kantola V., Kaufmann A., Laios A., Lam S., MacInnes E., Munot S., Nahm C., Otify M., Pompili C., Smith I., Theophilou G., Toogood G., Wade R., Ward D., West C., Annamalai S., Ashmore C., Boddy A., Hossain T., Kourdouli A., Gvaramadze A., Jibril A., Prusty L., Thekkinkattil D., Askari A., Cirocchi N., Kudchadkar S., Patel K., Sagar J., Shaw S., Talwar R., Abdalla M., Edmondson R., Ismail O., Jones D., Newton K., Stylianides N., Aderombi A., Andaleeb U., Bajomo O., Beatson K., Garrett W., Mehmood M., Ng V., Al-Habsi R., Divya G.S., Keeler B., Al-Sarireh B., Egan R., Harries R., Henry A., Kittur M., Li Z., Parkins K., Soliman F., Spencer N., Thompson D., Burgess C., Gemmell C., Grieco C., Hollyman M., Hunt L., Morrison J., Ojha S., Ryan N., Abbadessa F., Barnard S., Dawe N., Hammond J., Mahmoud A.F., McPherson I., Mellor C., Moir J., Pandanaboyana S., Powell J., Rai B., Roy C., Sachdeva A., Saleh C., Tingle S., Williams T., Manickavasagam J., McDonald C., McGrath N., McSorley N., Ragupathy K., Ramsay L., Solth A., Kakisi O., Seebah K., Shaikh I., Sreedharan L., Youssef M., Shah J., Ameerally P., McLarty N., Mills S., Shenfine A., Sahnan K., Abu J., Addae-Boateng E., Bratt D., Brock L., Burnside N., Cadwell-Sneath S., Gajjar K., Gan C., Grundy C., Hallam K., Hassell K., Hawari M., Joshi A., Khout H., Konstantinidi K., Lee R.X.N., Nunns D., Schiemer R., Walton T., Weaver H., Whisker L., Williamson K., McVeigh J., Myatt R., Williams M.A., Kaur R., Michel M., Patil S., Ravindran S., Sarveswaran J., Scott L., Edmond M., King E., Bhangu A., Breik O., Cato L.D., Griffiths E., Idle M., Kamal M., Kisiel A., Kulkarni R., Mak J.K.C., Martin T., Parente A., Parmar S., 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Chew D., Crank M., Ilenkovan N., MacDonald M., Narice B., Rominiyi O., Thompson A., Varley I., Drake T., Harrison E., Linder G., Mayes J., McGregor R., Skipworth R., Zamvar V., Hawkin P., Raymond T., Ryska O., Baron R., Dunne D., Gahunia S., Halloran C., Howes N., McKinney R., McNicol F., Russ J., Szatmary P., Tan J.R., Thomas A., Whelan P., Anzak A., Banerjee A., Fuwa O., Hughes F., Jayasinghe J.D., Knowles C., Kocher H., Leal S.I., Ledesma F.S., Minicozzi A., Navaratne L., Rahman R., Ramamoorthy R., Sohrabi C., Thaha M., Thakur B., Venn M., Yip V., Baumber R., Parry J., Evans S., Jeys L., Morris G., Parry M., Ahmadi N., Aresu G., Barrett-Brown Z.M., Durio Y.H., Gearon D., Hogan J., King M., Peryt A., Pradeep I.S., Adishesh M., Atherton R., Baxter K., Brocklehurst M., Chaudhury M., Krishnamohan N., McAleer J., Owens G., Parkin E., Patkar P., Phang I., Aladeojebi A., Ali M., Barmayehvar B., Gaunt A., Gowda M., Halliday E., Kitchen M., Mansour F., Thomas M., Zakai D., Abbassi-Ghadi N., Assalaarachchi H., Currie A., Flavin M., Frampton A., Hague M., Hammer C., Hopper J., Horsnell J., Humphries S., Kamocka A., Madhuri T.K., Preston S., Singh P., Stebbing J., Tailor A., Walker D., Aljanadi F., Jones M., Mhandu P., O'Donnell C., Turkington R., Al-Ishaq Z., Bhasin S., Bodla A.S., Burahee A., Crichton A., Fossett R., Pigadas N., Pickford S., Rahman E., Snee D., Yassin N., Fountain D., Hasan M.T., Karabatsou K., Laurente R., Pathmanaban O., Al-Mukhtar A., Giblin A., Kelty C., Lee M., Lye G., Newman T., Sharkey A., Steele C., Sureshkumar S.N., Whitehall E., Athwal R., Baker A., Jones L., Konstantinou C., Ramcharan S., Vatish J., Wilkin R., Ethunandan M., Sekhon G.K., Shields H., Singh R., Wensley F., Lyons A., Abbott T., Anwar S., Ghufoor K., Chung E., Hagger R., Hainsworth A., Karim A., Owen H., Ramwell A., Williams K., Baker C., Davies A., Gossage J., Kelly M., Knight W., Hall J., Harris G., James G., Kang C., Lin D.J., Rajgor A.D., Royle T., Scurrah R., Steel B., Watson L.J., Choi D., Hutchison R., Jain A., Luoma V., Marcus H., May R., Menon A., Pramodana B., Webber L., Aneke I.A., Asaad P., Brown B., Collis J., Duff S., Khan A., Moura F., Wadham B., Warburton H., Elmoslemany T., Jenkinson M., Millward C., Zakaria R., McCluney S., Parmar C., Shah S., Allison J., Babar M.S., Collard B., Goodrum S., Lau K., Scott R., Thomas E., Whitmore H., Balasubramaniam D., Jayasankar B., Kapoor S., Ramachandran A., Elhamshary A., Imam S.M.B., Kapriniotis K., Lindsay J., Rakhshani-Moghadam S., Beech N., Chand M., Green L., Kalavrezos N., Kiconco H., McEwen R., Schilling C., Sinha D., Pereca J., Chopra S., Egbeare D., Thomas R., Combellack T., Jones S.E.F., Kornaszewska M., Mohammed M., Sharma A., Tahhan G., Valtzoglou V., Williams J., Eskander P., Gash K., Gourbault L., Hanna M., MacCabe T., Newton C., Olivier J., Rozwadowski S., Teh E., West D., Al-Omishy H., Baig M., Bates H., Di T.G., Dickson K., Dunne N., Gill C., Howe D., Jeevan D., Khajuria A., Martin-Ucar A., McEvoy K., Naredla P., Robertson S., Sait M., Sarma D.R., Shanbhag S., Shortland T., Simmonds S., Skillman J., Tewari N., Walton G., Akhtar M.A., Brunt A., McIntyre J., Milne K., Rashid M.M., Sgro A., Stewart K.E., Turnbull A., Aguilar G.M., Talukder S., Boyle C., Fernando D., Gallagher K., Laird A., Tham D., Bath M., Patki P., Tanabalan C., Arif T., Magee C., Nambirajan T., Powell S., Vinayagam R., Flindall I., Hanson A., Mahendran V., Green S., Lim M., MacDonald L., Miu V., Onos L., Sheridan K., Young R., Alam F., Griffiths O., Houlden C., Jones R., Kolli V.S., Lala A.K., Leeson S., Peevor R., Seymour Z., Chen L., Henderson E., Brown K., Fleming D., Heron C., Hill C., Kay H., Leede E., McElhinney K., Olson K., Osterberg E.C., Riley C., Srikanth P., Thornhill M., Blazer D., Dilalla G., Hwang E.S., Lee W., Lidsky M., Plichta J., Rosenberger L., Scheri R., Turnage K., Visgauss J., Zani S., Farma J., Clark J., Kwon D., Etchill E., Gabre-Kidan A., Jenny H.E., Kent A., Ladd M., Long C., Malapati H., Margalit A., Rapaport S., Rose J., Stevens K., Tsai L., Vervoort D., Yesantharao P., Dehal A., Klaristenfeld D., Huynh K., Brown L., Mullinax J., Gusani N., Hazelton J., Maines J., Oh J.S., Ssentongo A., Ssentongo P., Azam M., Choudhry A., Marx W., Fleming J., Fuson A., Gigliotti J., Ovaitt A., Ying Y., Abel M.K., Andaya V., Bigay K., Boeck M.A., Chern H., Corvera C., El-Sayed I., Glencer A., Ha P., Hamilton B.C.S., Heaton C., Hirose K., Jablons D.M., Kirkwood K., Kornblith L.Z., Kratz J.R., Lee R., Miller P.N., Nakakura E., Nunez-Garcia B., O'Donnell R., Ozgediz D., Park P., Robinson B., Sarin A., Sheu B., Varma M., Wai K., Wustrack R., Xu M.J., Beswick D., Goddard J., Manor J., Song J., Fullmer T., Gaskill C., Gross N., Kiong K., Roland C.L., Zafar S.N., Abdallah M., Abouassi A., Almasri M., Kulkarni G., Marwan H., Mehdi M., Aoun S., Ban V.S., Batjer H.H., Caruso J., Abbott D., Acher A., Aiken T., Barrett J., Foley E., Schwartz P., Hawkins A., Maiga A., Laufer J., Scasso S., Zweroncy, A., Glasbey, J, Omar, O, Nepogodiev, D, Minaya-Bravo, A, Bankhead-Kendall, B, Fiore, M, Futaba, K, Gujjuri, R, Isik, A, Kaafarani, H, Kamarajah, S, Li, E, Loffler, M, Mclean, K, Oumaima, O, Faustin, N, Sohei, S, Shaw, R, Simoes, J, Stewart, G, Tabiri, S, Trout, I, Bhangu, A, Siaw-Acheampong, K, Benson, R, Bywater, E, Chaudhry, D, Dawson, B, Evans, J, Heritage, E, Jones, C, Khatri, C, Khaw, R, Keatley, J, Knight, A, Lawday, S, Mann, H, Marson, E, Mckay, S, Mills, E, Pellino, G, Picciochi, M, Taylor, E, Tiwari, A, Venn, M, Wilkin, R, Aneel, B, Smart, N, Gallo, G, Moug, S, Pata, F, Pockney, P, Saverio, S, Vallance, A, Vimalchandran, D, Roberts, K, Isaac, J, Edwards, J, Coonar, A, Marchbank, A, Caruana, E, Layton, G, Patel, A, Brunelli, A, Ford, S, Desai, A, Gronchi, A, Almond, M, Tirotta, F, Sinziana, D, Price, S, Fountain, D, Jenkinson, M, Hutchinson, P, Marcus, H, Piper, R, Lippa, L, Servadei, F, Esene, I, Freyschlag, C, Neville, I, Rosseau, G, Schaller, K, Demetriades, A, 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A., Persiani R., Carrano F. M., De Virgilio A., Di Candido F., Emanuele P., De Berardinis R., Fumagalli Romario U., De Manzoni Garberini A., Sampietro G. M., Isolani S. M., Baietti A. M., Prucher G. M., Zarabini A. G., Marino Cosentino L., Nespoli L. C., Di Martino C., Spampinato M. G., Cicerchia P. M., De Toma G., Di bartolomeo A., Fonsi G. B., La Torre F., Scafa A. K., Capolupo G. T., De Nardi P., Ottolina J., De Crescenzo E., De Iaco P., Mineo Bianchi F., Perrone A. M., Pezzuto A. P., Di Maria Grimaldi S., Giuffrida M. C., Santonocito O. S., Fulginiti S. F., Di Marzo F., Kobayashi Kato M., Al Abdallah M., Abu Za'nouneh F. J., Abdel Al S., Abdel Jalil R., Abou Chaar M. K., Alkadeeki G., Subhi M. T., Kilani A. I., Razafindrahita J. B., Samison L. H., Ong E. C., Hamdan K. H., Ibrahim M. R., Tan J. A., Thanapal M. R., Amin Sahid N., Sriram R. K., Che Jusoh A., Hussain A. H., Mohamed Sidek A. S., Mohd Yunus M. F., Soh J. Y., Mpk W., Zakaria A. D., Fathi N. Q., Koh P. S., Liew Y. 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I., Martins dos Santos G., Ribeiro V. I., Baptista V. H., Melo Neves J. P., Bandovas J. P., Figueiredo de Barros I., Maciel J., Silveira Nunes I., Peralta Ferreira M., Rio Rodrigues L., Sousa Fernandes M., Soares A. C., Pmdd S., Vieira Paiva Lopes A. C., Mendes J. R., Abreu da Silva A., Costa Santos D., Deus A. C., Grilo J. V., Corte Real J., Lima M. J., Matos Costa P., Brito da Silva F., Baiao J. M., Martins Jordao D., Vieira Caroco T., Correia A. M., Videira J. F., Escobar P., Maldonado Santiago M., Kassir R., Sauvat F., Iosifescu R. V., Al Raddadi R., Al Awwad S., Al Habes H., Cortes Guiral D., Bin Nasser A., Bin Traiki T., Rabah P. D., Cerovic Popovic R., Ladjevic Likic I., Chan C. W., Van Wyngaard T., Castano-Leon A. M., Delgado Fernandez J., Eiriz Fernandez C., Espino Segura-Illa M., Esteban Sinovas O., Garcia Perez D., Perez Nunez A., Sanchez Aniceto G., Fernandez Rodriguez P., Paniagua Garcia Senorans M., Baena Sanfeliu E., Sorribas Grifell M., Vives R. V., Cayetano Paniagua L., Gomez Fernandez L., Bernal-Sprekelsen J. C., Catala Bauset J. C., Diaz Del Gobbo R., Farre Font R., Flores Clotet R., Gomez Diaz C. J., Guariglia C. A., Sanchez Jimenez R., Soto Montesinos C., Albi Martin B., Garcia Villayzan J. E., Baeza Pintado N., Jimenez Miramon J., Jover J. M., Landeo Aguero S. A., Perez Simon V., Rodriguez J. L., Valle Rubio A., Aldecoa Ansorregui I., Bravo Infante R., De Lacy F. B., Di Somma A., Ensenat Nora J., Gil Ibanez B., Gonzalez Sanchez J. J., Hoyos Castro J. A., Lacy A. M., Poblete Carrizo J., Reyes Figueroa L. A., Roldan Ramos P., Tercero-Uribe A. I., Topczewski T. E., Del Campo Martin M., Garcia Alonso M., Garcia Romero E., Gomez Latorre L., Muguerza J. M., Pizarro M. J., Saez Carlin P., Sanchez del Pueblo C., Sanz Ortega G., Beltran de Heredia J., De Andres Asenjo B., Gomez Sanz T., Nunez Del Barrio H., Ortiz de Solorzano Aurusa F. J., Romero de Diego A., Ruiz Soriano M., Trujillo Diaz J., Sosa M. V., Minaya Bravo A. M., Cazador Labat M., Espinosa C. A., Jimenez Toscano M., Lopez Campillo A., Grau-Talens E. J., Benavides Buleje J. A., Carrasco Prats M., Fernandez P. V., Garcia Escudero D., Garcia Porcel V. J., Garcia Soria V., Gimenez Frances C., Gonzalez Valverde F. M., Marco Garrido A., Martinez Alonso J. A., Munoz Camarena J. M., Parra Banos P. A., Pena Ros E., Ramirez Faraco M., Sanchez Rodriguez C., Valero Soriano M., Estaire Gomez M., Fernandez Camunas A., Garcia Santos E. P., Jimenez Higuera E., Picon Rodriguez R., Redondo Calvo F. J., Colombari R. C., Lozano Lominchar P., Rey Valcarcel C., Zorrilla Ortuzar J., Alcaide Matas F., Garcia Perez J. M., Troncoso Pereira P., Achalandabaso Boira M., Memba Ikuga R., Sales Mallafre R., Cavalle Busquets P., Mgp G. P., Salinas Pena J., Aragon Achig E. J., Caja Vivancos P., Garcia Gutierrez J. J., Mallabiabarrena Ormaechea G., Martin Playa P., Melchor Corcostegui I., Prieto Calvo M., Rodriguez Fraga A., Villalabeitia Ateca I., De Andres Olabarria U., Duran Ballesteros M., Fernandez Pablos F. J., Ibanez-Aguirre F. J., Sanz Larrainzar A., De la Hoz Rodriguez A., Di Martino M., Garcia Septiem J., Munoz de Nova J. L., Calvo Espino P., Guillamot Ruano P., Colao Garcia L., Diaz Perez D., Esteban Agusti E., Galindo Jara P., Gutierrez Samaniego M., Serrano Gonzalez J., Alonso Poza A., Chiesa-Estomba C. M., Gonzalez Garcia J. A., Sistiaga-Suarez J. A., Garcia Pineda V., Gegundez Simon A., Hernandez Gutierrez A., Maria Dolores D. T., Prieto Nieto M. I., Sanchez-Mendez J. I., Siegrist Ridruejo J., Gascon Ferrer I., Gonzalez-Nicolas Trebol M. T., Herrero Lopez M., Jariod Ferrer U. M., Martinez German A., Sanchez Fuentes N., Simon Sanz M. V., Blazquez Martin A., Diez Alonso M., Garcia Rico E., Garcia-Loarte Gomez E., Garcia-Moreno Nisa F., Gutierrez Calvo A., Morales Palacios N., Ovejero Merino E., Vera Mansilla C., Acebes Garcia F., Bueno Canones A. D., Choolani Bhojwani E., Pacheco Sanchez D., Sanchez Gonzalez J., Gil Martinez J., Gutierrez Fernandez A. I., Lopez Abad A., Ramirez Romero P., Roca Calvo M. J., Ruiz Manzanera J. J., Soriano A. I., Cintas Catena J., Oliva Mompean F., Rio Lafuente F. D., Torres Arcos C., Marina Martin T., Martinez Chicote C., Landaluce-olavarria A., Abad Gurumeta A., Ruiz Escobar A., Garcia-Sancho Tellez L., Heras Aznar J., Ortega Vazquez I., Picardo A. L., Rojo Lopez J. A., Sanchez Cabezudo Noguera F., Serralta de Colsa D., Anchuelo Latorre J., Cagigas Fernandez C., Caina Ruiz R., Gomez Ruiz M., Jimeno Fraile J., Santarrufina Martinez S., Valbuena Jabares V., Ruiz Martin I., Blas Laina J. L., Garcia Egea J., Talal El-Abur I., Cagigal Ortega E. P., Diaz Pena P., Gdcr E., Fernandez Bernabe P., Garces Garcia R., Marqueta De Salas M., Martinez Pascual P., Perez Gonzalez M., Ramos Bonilla A., Rodriguez Gomez L., De Pablo Garcia-Cuenca A., Giralt Lopez de Sagredo J., Pujol Pina R., Gbk B., Rodrigo V. S., Lindqvist E. K., Di Giuseppe M., La Regina D., Crugnale A. S., Ozmen B. B., Arikan A. E., Bilgin I. A., Ceyhan G. O., Dincer H. A., Salman M. C., OZcelik M. F., Sanli A. N., Uludag S. S., Zengin A. K., Azamat I. F., Kulle C. B., Guler S. A., Tatar O. C., Utkan N. Z., Kucuk I. F., Kucuk G. O., Avci E. K., Demirli Atici S., Cheung L. K., Davies R. J., Khan D. Z., Mitrofan C. G., Pushpa-rajah J., Tan X. S., Mfi D. L. C. M., Roy Mahapatra S., Serevina O. L., Labib P. L., Kyk K., Ng H. J., De Gea Rico A., Vaz O. P., Sundaram Venkatesan G., Chowdhry M. F., Aboelkassem Ibrahim A., Akw C., Ssa Q., Thulasiraman S. V., Ccl L., Di Chiara F., Obf R., Tebala G. D., Bhatti M. I., Harky A., Shackcloth M., Divya G. S., Mahmoud Ali F., Rxn L., Jkc M., Pathanki A. M., Khan A. H., Tan K. L., Malcolm F. L., Hidalgo Salinas C., Machairas N., Pollok J. M., Raptis D. A., Xyda S. E., Macdonald M., Tan J. R., Leal Silva I., Ledesma F. S., Barrett-Brown Z. M., Durio Yates H., Pradeep I. S., Madhuri T. K., Bodla A. S., Hasan M. T., Al-mukhtar A., Sureshkumar Shah N., Sekhon G. K., Lin D. J., Rajgor A. D., Watson L. J., Aneke I. A., Mccluney S., Smb I., Sef J., Maccabe T., Al-omishy H., Di Taranto G., Sarma D. R., Stewart K. E., Aguilar Gonzalez M., Kolli V. S., Lala A. K., Osterberg E. C., Hwang E. S., Jenny H. E., Oh J. S., Abel M. K., El-sayed I., Bcs H., Kornblith L. Z., Kratz J. R., Miller P. N., Xu M. J., Roland C. L., Zafar S. N., Ban V. S., Batjer H. H., Apollo - University of Cambridge Repository, and Collaborative, COVIDSurg
Subjects: Lung Diseases, Male, AcademicSubjects/MED00910, COVID-19/diagnosis, Settore MED/18 - CHIRURGIA GENERALE, neoplasms, 030230 surgery, minorsurgical procedures, Medical and Health Sciences, Lung Disease, 0302 clinical medicine, Postoperative Complications, 030202 anesthesiology, aged, aged, 80 and over, COVID-19, elective surgical procedures, female, humans, lung diseases, male, middle aged, Nasopharynx, pandemics, postoperative complications, risk assessment, SARS-CoV-2, COVID-19 nucleic acid testing, Neoplasms, 80 and over, 030212 general & internal medicine, 610 Medicine & health, Lung, Cancer, Aged, 80 and over, Incidence (epidemiology), Confounding, Pulmonary Complication, Lung Diseases/*etiology, Neoplasms/surgery, General Medicine, Middle Aged, Elective Surgical Procedures/adverse effects, Oncology, Elective Surgical Procedures, 030220 oncology & carcinogenesis, COVID-19 Nucleic Acid Testing, Original Article, Female, Patient Safety, AcademicSubjects/MED00010, Elective Surgical Procedure, 6.4 Surgery, Human, Cohort study, medicine.medical_specialty, preoperative caresurgical procedures, Preoperative care, Risk Assessment, Article, COVIDSurg Collaborative, NO, Vaccine Related, 03 medical and health sciences, Clinical Research, Biodefense, medicine, Nasopharynx/*virology, Humans, Nasopharynx/virology, Elective surgery, Adverse effect, Pandemics, LS7_4, Aged, Pandemic, business.industry, Surgery, Sars Cov2, Prevention, No key words available, electivesurgical procedures, Lung Diseases/etiology, Evaluation of treatments and therapeutic interventions, Postoperative complication, operativenasopharynxsurgery specialtypulmonary complicationscancer surgerysars-cov-2covid-19coronavirus pandemic, Odds ratio, medicine.disease, Confidence interval, Surgery, COVID-19/*diagnosis, Emerging Infectious Diseases, Good Health and Well Being, Neoplasm, Postoperative Complication, preoperative caresurgical procedures, electivesurgical procedures, minorsurgical procedures, operativenasopharynxsurgery specialtypulmonary complicationscancer surgerysars-cov-2covid-19coronavirus pandemic, Elective Surgical Procedures/*adverse effects, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Background Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. Methods This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. Results Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. Conclusion Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas., This was an international cohort study of 8784 patients undergoing elective cancer surgery during the COVID-19 pandemic. Preoperative nasopharyngeal swab testing for SARS-CoV-2 was associated with a reduction in postoperative pulmonary complications. This was consistent for major surgery and in high-incidence areas, but with no proven benefit before minor surgery in low-incidence areas.
Published: 2021
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19. Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Author: Writing Group (denotes joint first author) James, C Glasbey (UK), Dmitri Nepogodiev (UK), Joana FF Simoes (Portugal), Omar Omar (UK), Elizabeth Li (UK), Mary, L Venn (UK), Mohammad Abou Chaar (Jordan), Vita Capizzi (Italy), Daoud Chaudhry (UK), Anant Desai (UK), Jonathan, G Edwards (UK), Jonathan, P Evans (UK), Marco Fiore (Italy), Jose Flavio Videria (Portugal), Samuel, J Ford (UK), Ian Ganyli (USA), Ewen, A Griffiths (UK), Rohan, R Gujjuri (UK), Angelos, G Kolias (UK), Haytham MA Kaafarani (USA), Ana Minaya-Bravo (Spain), Siobhan, C McKay (UK), Helen, M Mohan (Ireland), Keith Roberts (UK), Carlos San Miguel-M&#233, ndez (Spain), Peter Pockney (Australia), Richard Shaw (UK), Neil, J Smart (UK), Grant, D Stewart (UK), Sudha Sundar (UK), Raghavan Vidya (UK), Aneel, A Bhangu (UK, Statistical analysis Glasbey JC, Overall guarantor)., Omar, O (Lead statistician), Bhangu, A CovidSurg Operations Committee Kwabena Siaw-Acheampong, Ruth, A Benson, Edward, Bywater, Daoud, Chaudhry, Brett, E Dawson, Jonathan, P Evans, James, C Glasbey, Rohan, R Gujjuri, Emily, Heritage, Conor, S Jones, Sivesh, K Kamarajah, Chetan, Khatri, Rachel, A Khaw, James, M Keatley, Andrew, Knight, Samuel, Lawday, Elizabeth, Li, Harvinder, S Mann, Ella, J Marson, Kenneth, A McLean, Siobhan, C Mckay, Emily, C Mills, Dmitri, Nepogodiev, Gianluca, Pellino, Maria, Picciochi, Elliott, H Taylor, Abhinav, Tiwari, Joana FF Simoes, Isobel, M Trout, Mary, L Venn, Richard JW Wilkin, International Cancer Leads (denotes specialty Principal Investigators) James C Glasbey (Chair), Aneel Bhangu., Colorectal: Neil, J Smart, Ana, Minaya-Bravo, Susan, Moug, Dale, Vimalchandran, Abigail, Vallance, Peter, Pockney, Oesophagogastric: Ewen, A Griffiths, Richard PT Evans, Philip, Townend, Hepatopancreatobilary: Keith Roberts, Siobhan, McKay, John, Isaac, Sohei, Satoi, Thoracic: John Edwards, Aman, S Coonar, Adrian, Marchbank, Edward, J Caruana, Georgia, R Layton, Akshay, Patel, Alessandro, Brunelli, Sarcoma: Samuel Ford, Anant, Desai, Alessandro, Gronchi, Marco, Fiore, Max, Almond, Fabio, Tirotta, Sinziana, Dumitra, Neurosurgery: Angelos Kolias, Stephen, J Price, Daniel, M Fountain, Michael, D Jenkinson, Peter, Hutchinson, Hani, J Marcus, Rory, J Piper, Laura, Lippa, Franco, Servadei, Ignatius, Esene, Christian, Freyschlag, Iuri, Neville, Gail, Rosseau, Karl, Schaller, Andreas, K Demetriades, Faith, Robertson, Alex, Alamri, Head and neck: Richard Shaw, Andrew, G Schache, Stuart, C Winter, Michael, Ho, Paul, Nankivell, Juan Rey Biel, Martin, Batstone, Ian, Ganly, Breast: Raghavan Vidya, Alex, Wilkins, Jagdeep, K Singh, Dinesh, Thekinkattil, Gynaecology: Sudha Sundar, Christina, Fotopoulou, Elaine, Leung, Tabassum, Khan, Luis, Chiva, Jalid, Sehouli, Anna, Fagotti, Paul, Cohen, Murat, Gutelkin, Rahel, Ghebre, Thomas, Konney, Rene, Pareja, Rob, Bristow, Sean, Dowdy, Shylasree TS Rajkumar, Joe, Ng, Keiiji, Fujiwara, Urology: Grant, D Stewart, Benjamin, Lamb, Krishna, Narahari, Alan, McNeill, Alexandra, Colquhoun, John, McGrath, Steve, Bromage, Ravi, Barod, Veeru, Kasivisvanathan, Dissemination Committee Joana FF Simoes (Chair), Tobias Klatte., Tom EF Abbott, Michel, Adamina, Adesoji, O Ademuyiwa, Arnav, Agarwal, Ehab, Alameer, Derek, Alderson, Felix, Alakaloko, Markus, Albertsmeiers, Osaid, Alser, Muhammad, Alshaar, Sattar, Alshryda, Alexis, P Arnaud, Knut Magne Augestad, Faris, Ayasra, Jos&#233, Azevedo, Brittany, K Bankhead-Kendall, Emma, Barlow, Ruth, Blanco-Colino, Amanpreet, Brar, Kerry, A Breen, Chris, Bretherton, Igor Lima Buarque, Joshua, Burke, Mohammad, Chaar, Sohini, Chakrabortee, Peter, Christensen, Daniel, Cox, Moises, Cukier, Miguel, F Cunha, Giana, H Davidson, Salomone Di Saverio, Thomas, M Drake, John, G Edwards, Muhammed, Elhadi, Sameh, Emile, Shebani, Farik, J Edward Fitzgerald, Samuel, Ford, Tatiana, Garmanova, Gaetano, Gallo, Dhruv, Ghosh, Gustavo Mendon&#231, a Ata&#237, de Gomes, Gustavo, Grecinos, Ewen, A Griffiths, Madalegna, Gr&#252, ndl, Constantine, Halkias, Ewen, M Harrison, Intisar, Hisham, Peter, J Hutchinson, Shelley, Hwang, Arda, Isik, Pascal, Jonker, Haytham MA Kaafarani, Angelos, Kolias, Schelto, Kruijff, Ismail, Lawani, Hans, Lederhuber, Sezai, Leventoglu, Andrey, Litvin, Andrew, Loehrer, Markus, W L&#246, ffler, Maria Aguilera Lorena, Maria Marta Madolo, Piotr, Major, Janet, Martin, Hassan, N Mashbari, Dennis, Mazingi, Symeon, Metallidis, Helen, M Mohan, Rachel, Moore, David, Moszkowicz, Joshua, S Ng-Kamstra, Mayaba, Maimbo, Milagros, Niquen, Faustin, Ntirenganya, Maricarmen, Olivos, Kacimi, Oussama, Oumaima, Outani, Marie Dione Parreno-Sacdalanm, Francesco, Pata, Carlos Jose Perez Rivera, Thomas, D Pinkney, Willemijn van der Plas, Ahmad, Qureshi, Dejan, Radenkovic, Antonio Ramos- De la Medina, Keith, Roberts, April, C Roslani, Martin, Ruteg&#229, Ir&#232, ne, Santos, Raza, Sayyed, Andrew, Schache, Andreas, A Schnitzbauer, Seyi-Olajide, Justina O., Neil, Sharma, Richard, Shaw, Sebastian, Shu, Kjetil, Soreide, Antonino, Spinelli, Grant, D Stewart, Malin, Sund, Sudha, Sundar, Stephen, Tabiri, Georgios, Tsoulfas, Gabrielle, H van Ramshorst, Raghavan, Vidya, Dale, Vimalachandran, Oliver, J Warren, Duane, Wedderburn, Naomi, Wright, EuroSurg, European Society of Coloproctology (ESCP), Global Initiative for Children&#8217, s Surgery (GICS), GlobalSurg, GlobalPaedSurg, ItSURG, PTSurg, SpainSurg, Italian Society of Colorectal Surgery (SICCR), Association of Surgeons in Training (ASiT), Irish Surgical Research Collaborative (ISRC), Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), Collaborators (denotes Site Principal Investigators) Argentina: Allemand C, Italian Society of Surgical Oncology (SICO)., Boccalatte, L, Figari, M, Lamm, M, Larra&#241, aga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L (Hospital Italiano De Buenos Aires), Alurralde, C, Caram, El, Eskinazi, D, Mendoza, Jp, Usandivaras M (Sanatorio, 9 De Julio Sa), Badra, R, Esteban, A, Garc&#237, a, Js, a, Pm, Gerchunoff, Ji, Lucchini, Sm, NIgra, Ma, Armenia: Hovhannisyan T, Vargas L (Sanatorio Allende)., Australia: Gould T, Stepanyan A (Nairi Medical Center)., Gourlay, R, Griffiths, B (Calvary Mater Newcastle), Gananadha S, McLaren M (Canberra Hospital), Cecire, J, Joshi, N, Salindera, S, Sutherland, A (Coffs Harbour Health Campus), Ahn, Jh, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H (Concord Repatriation General Hospital), Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, Vo UG (Fiona Stanley Hospital), Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Lam, Yh, Ong, Bs, Szpytma, M, Watson, D (Flinders Medical Centre), Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, Nolan, Gj, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M (Gold Coast University Hospital), Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N (John Hunter Hospital), Elliott M, Phung D (Lifehouse), Phan D, Townend D (Lismore Base Hospital), Bong C, Gundara J (Logan Hospital), Frankel, A (Princess Alexandra Hospital), Bowman S, Guerra GR (Queen Elizabeth Ii Jubilee Hospital), Bolt, J, Buddingh, K, Dudi-Venkata, Nn, Jog, S, Kroon, Hm, Sammour, T, Smith, R, Stranz, C (Royal Adelaide Hospital), Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B (Royal Brisbane And Women&#8217, s Hospital), Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, Mw, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Austria: Lanner M (Kardinal Schwarzenberg Klinikum), Wright G (St Vincent&#8217, s Hospital)., K&#246, nigsrainer, I (Landeskrankenhaus Feldkirch), Bauer, M, Freyschlag, C, Kafka, M, Messner, F, 214, fner, D, Tsibulak, I (Medical University Of Innsbruck), Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, hlberger, L, Presl, J, Azerbaijan: Namazov &#304, Wimmer A (Paracelsus Medical University Salzburg)., Barbados: Barker D, Samadov E (Leyla Medical Centerl)., Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O&#8217, Shea, M, Padmore, G, Paquette, N, Phillips, E, John S, St., Belgium: Flamey N, Walkes K (Queen Elizabeth Hospital)., Pattyn, P (Az Delta), Oosterlinck, W, Van den Eynde, J, Brazil: Gatti A, Van den Eynde R (Uz Leuven)., Nardi, C, Oliva, R (Hospital Geral De Pirajussara), De Cicco, R (Instituto De C&#226, ncer Dr Arnaldo Vieira De Carvalho), Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, Canada: Kidane B, Terra RM (Instituto Do C&#226, ncer De Estado De S&#227, o Paulo). Bulgaria: Sokolov M (University Hospital Alexandrovska)., Srinathan, S (Health Sciences Centre), Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S (Jewish General Hospital), Dumitra, S, Kouyoumdjian, A (Mcgill University Health Center), Johnston B, Russell C (Saint John Regional Hospital), Demyttenaere, S, Mary&#8217, s Hospital), Garfinkle R (St., Abou-Khalil, J, Nessim, C, Colombia: Almeciga A, Stevenson J (The Ottawa Hospital). Chile: Heredia F (Cl&#237, nica Universitaria De Concepci&#243, n)., Fletcher, A, Merchan A (Centro De Investigaciones Oncol&#243, gicas Cl&#237, nica San Diego, - Ciosad), Puentes LO (Hospital San Jos&#233, Croatia: Ba&#269, i&#263, G, Mendoza Quevedo J (Subred Sur Occidente De Kennedy (Hospital De Kennedy))., Karlovi&#263, D, Kr&#353, ul, D, Zeli&#263, M (University Hospital Center Rijeka), Luksic I, Mamic M (University Hospital Dubrava), Bakmaz, B, 262, oza, I, Dijan, E, Katusic, Z, Mihanovic, J, Cyprus: Frantzeskou K, Rakvin I (Zadar General Hospital)., Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Czechia: Martinek L, Yiallourou A (Nicosia General Hospital)., Skrovina, M, Szubota, I (Hospital &amp, amp, Oncological Centre Novy Jicin), 381, ateck&#253, J (Slezsk&#225, Nemocnice V Opav&#283, P. o. ), Javurkova, V, Denmark: Avlund T, Klat J (University Hospital Ostrava)., Christensen, P, Harbjerg, Jl, Iversen, Lh, Kjaer, Dw, Kristensen, H&#248, Mekhael, M (Aarhus University Hospital), Ebbeh&#248, j, Al, Krarup, P, Schlesinger, N, Egypt: Abdelsamed A, Smith H (Bispebjerg Hospital)., Azzam, Ay, Salem, H, Seleim, A (Al Azhar University Hospitals), Abdelmajeed, A, Abdou, M, Abosamak, Ne, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elhoseiny, M, Elnemr, M, Elqasabi, Ms, Elsayed Hewalla ME, Elsherbini, I, Essam, E, Eweda, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, Ms, Ragab, M, Sabry, A, Saifeldin, H, Saleh Mesbah Mohamed Elkaffas, M, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K (Alexandria Main University Hospital), Attia, D, Kamal, N, Osman, N (Alexandria Medical Research Institute), Abbas, Am, Abd Elazeem HAS, Abdelkarem, Mm, Alaa, S, Ali, Ak, Ayman, A, Azizeldine, Mg, Elkhayat, H, elghazaly S, M., Monib, Fa, Nageh, Ma, Saad, Mm, Salah, M, Shahine, M, Yousof, Ea, Youssef, A (Assiut University Hospital), Eldaly, A (El-Menshawy Hospital), ElFiky, M, Nabil, A (Kasr Alainy Faculty Of Medicine, Cairo, University), Amira, G, Sallam, I, Sherief, M, Sherif, A (Misr Cancer Center), Abdelrahman, A, Aboulkassem, H, Ghaly, G, Hamdy, R, Morsi, A, Sherif, G (National Cancer Institute), Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, Sherif AE (National Liver Institute, Finland: Kauppila J, Menoufia University). Ethiopia: Bekele D (Maddawalabu University Goba Referral Hospital)., Sarjanoja, E (L&#228, nsi-Pohja Central Hospital), Helminen, O, Huhta, H, France: Beyrne C, Kauppila JH (Oulu University Hospital)., Jouffret, L, Lugans, L, Marie-Macron, L (Centre Hospitalier Avignon), Chouillard E, De Simone B (Centre Hospitalier Intercommunal Poissy Saint Germain En Laye), Bettoni, J, Dakp&#233, S, Devauchelle, B, Lavagen, N, Testelin, S (Chu Amiens), Boucher, S, Breheret, R, Gueutier, A, Kahn, A, K&#252, n-Darbois, J (Chu Angers), Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P (Chu Besan&#231, on), Chebaro, A, Drubay, V, El amrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, Pruvot, Fr, Truant, S, Zerbib, P (Chu Lille), Ballouhey, Q, Barrat, B, Laloze, J, Salle, H, Taibi, A, Usseglio, J (Chu Limoges), Bergeat D, Merdrignac A (Chu Rennes - General Surgery), Le Roy, B, Perotto, Lo, Scalabre, A (Chu Saint Etienne), Aim&#233, A, Ezanno, A, Malgras, B (Hia Begin), Bouche P, Tzedakis S (H&#244, pital Cochin - Aphp), Cotte, E, Glehen, O, Lifante, J (Hopital Lyon Sud), D&#8217, Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B (Hus, Pole H&#233, pato-Digestif, / Ihu- Strasbourg), Bardet, J, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Moumen, A, Pourcher, G, Seguin-givelet, A, Tribillon, E (Institut Mutualiste Montsouris), Duchalais, E, Espitalier, F, Ferron, C, Germany: Bork U, Malard O (Nantes University Hospital)., Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P (Carl-Gustav-Carus University, Dresden), Tu, Beyer, K, Kamphues, C, Lauscher, J, Loch, Fn, Schineis, C (Charit&#233, University Medicine, Campus Benjamin Franklin), Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J (Department of General, Visceral and Transplantation Surgery, Ludwig- Maximilians-Universitat Munich), Becker R, Jonescheit J (Heilig-Geist Hospital Bensheim), Pergolini I, Reim D (Klinikum Rechts Der Isar Tum School Of Medicine), Boeker, C, Hakami, I, Mall, J (Krh Nordstadt-Siloah Hospitals), Liokatis P, Smolka W (LMU Klinikum Campus Innenstadt), Nowak K, Reinhard T (Romed Klinikum Rosenheim), H&#246, lzle, F, Modabber, A, Winnand, P (University Hospital Aachen), Knitschke, M (University Hospital Giessen And Marburg), Kauffmann P, Wolfer S (University Hospital Goettingen / Universit&#228, tsmedizin Goettingen), Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R (University Hospital Halle (Saale)), Bertolani, E, nigsrainer, A, L&#246, ffler, Mw, Quante, M, Steidle, C, 220, berr&#252, ck, L, Yurttas, C (University Hospital Tuebingen), Betz, Cs, Bewarder, J, B&#246, ttcher, A, Burg, S, Busch, C, Gosau, M, Heuer, A, Izbicki, J, Klatte, To, Koenig, D, Moeckelmann, N, Nitschke, C, Priemel, M, Smeets, R, Speth, U, Thole, S, Uzunoglu, Fg, Vollkommer, T, Zeller, N (University Medical Center Hamburg- Eppendorf), Battista, Mj, Gillen, K, Hasenburg, A, Krajnak, S, Linz, V, Schwab, R (University Of Mainz, Greece: Angelou K, Department Of Gynaecology And Obstetrics)., Haidopoulos, D, Rodolakis, A (Alexandra General Hospital), Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A (Aretaieion Hospital), Antonopoulou, Mi, Manatakis, Dk, Tasis, N (Athens Naval And Veterans Hospital), Arkadopoulos, N, Danias, N, Economopoulou, P, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Selmani, J, Sidiropoulos, T, Tsaousis, V, Vassiliu, P (Attikon University General Hospital), Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G (Evaggelismos General Hospital), Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Koukoulis, G, Ntziovara, Am, Petropoulos, K, Soulikia, K, Tsiamalou, I, Zervas, K, Zourntou, S (General Hospital Of Larissa &#8220, Koutlimpaneio And Triantafylleio&#8221, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D (General University Hospital Of Larissa), Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G (George Papanikolaou General Hospital Of Thessaloniki), Karaitianos I, Tsirlis T (Henry Dunant Hospital Center), Charalabopoulos, A, Liakakos, T, Mpaili, E, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C (Laiko University Hospital), Anthoulakis, C, Christou, C, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D (Papageorgiou General Hospital), Athanasakis, E, Chrysos, E, Tsiaousis, J, Xenaki, S, Hong Kong: Futaba K, Xynos E (University Hospital Of Heraklion Crete And Interclinic Hospital Of Crete)., Ho, Mf, Hon, Sf, Mak, Twc, Ng SSM (Prince Of Wales Hospital), Hungary: Banky B, Foo CC (Queen Mary Hospital)., Ireland: Aremu M, Suszt&#225, k N (Szent Borb&#225, la K&#243, rh&#225, z)., Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L (Connolly Hospital Blanchardstown), Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Killeen, S, Lynch, N, McCarthy, A, Mustafa, H, Brien, S, Leary, P, Syed, Was, Vernon, L (Cork University Hospital), Callanan, D, Huang, L, Ionescu, A, Sheahan, P (South Infirmary Victoria University Hospital), Balasubramanian, I, Boland, M, Conlon, K, Evoy, D, Fearon, N, Gallagher, T, Geraghty, J, Heneghan, H, Kennedy, N, Maguire, D, McCartan, D, McDermott, Ew, Prichard, Rs, Winter, D (St Vincent&#8217, s University Hospital), Alazawi, D, Barry, C, Boyle, T, Butt, W, Connolly, Em, Donlon, N, Donohue, C, Fahey, Ba, Farrell, R, Fitzgerald, C, Kinsella, J, Larkin, Jo, Lennon, P, Maguire, Pj, Mccormick, P, Mehigan, Bj, Mohan, H, Nugent, T, Sullivan, H, Ravi, N, Reynolds, Jv, Rogers, A, Shokuhi, P, Smith, J, Smith, La, James&#8217, s Hospital), Timon C (St., Bashir, Y, Bass, G, Connelly, T, Earley, H, Elliott, Ja, Gillis, A, Kavanagh, D, Neary, P, riordan, J, Reynolds, Is, Rice, D, Ridgway, P, Umair, M, Whelan, M (Tallaght Hospital), Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, A, Hogan, A, Kerin, M, Lowery, A, McAnena, P, McKevitt, K, Nizami, K, Ryan, &#201, Samy, A (University Hospital Galway), Coffey, Jc, Cunningham, R, Devine, M, Nally, D, Peirce, C, Tormey, S (University Hospital Limerick), Hardy, N, Malley, S, Italy: Macina S (Asst Mantua), Ryan M (University Hospital Waterford/University College Cork)., Mariani, Nm, Opocher, E, Pisani Ceretti A (Asst Santi Paolo, E Carlo), Ferrari, F, Odicino, F, Sartori, E (Asst Spedali Civili, Ospedale Di Brescia), Cotsoglou C, Granieri S (Asst Vimercate), Bianco, F, Camillo&#8217, Colledan, M, Tornese, S, Zambelli MF (Asst-Papa Giovanni Xxiii- Bergamo), Bissolotti, G, Fusetti, S, Lemma, F (Azienda Ospedaliera Di Padova), Marino, M, Mirabella, A, Vaccarella, G (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo), Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, De Vincenti, R, Di Bella, A, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, Ringressi, Mn, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R (Azienda Ospedaliera Universitaria Careggi), Bassi, C, Campagnaro, T, Casetti, L, De Pastena, M, Esposito, A, Fontana, M, Guglielmi, A, Landoni, L, Malleo, G, Marchegiani, G, Nobile, S, Paiella, S, Pedrazzani, C, Rattizzato, S, Ruzzenente, A, Salvia, R, Turri, G, Tuveri, M (Azienda Ospedaliera Universitaria Integrata Di Verona), Bellora, P, Aloisio, G, Ferrari, M, Francone, E, Gentilli, S, Nikaj, H (Azienda Ospedaliero Universitaria Maggiore Della Carit&#224, Bianchini, M, Chiarugi, M, Coccolini, F, Di Franco, G, Furbetta, N, Gianardi, D, Guadagni, S, Morelli, L, Palmeri, M, Tartaglia, D (Azienda Ospedaliero Universitaria Pisana), Anania, G, Carcoforo, P, Chiozza, M, De Troia, A, Koleva Radica, M, Portinari, M, Sibilla, Mg, Urbani, A (Azienda Ospedaliero Universitaria Sant&#8217, anna), Fabbri, N, Feo, Cv, Gennari, S, Parini, S, Righini E (Azienda Unit&#224, Sanitaria Locale di Ferrara, - University of Ferrara), Ampollini, L, Bellanti, L, Bergonzani, M, Bertoli, G, Bocchialini, G, Angelo, G, Lanfranco, D, Musini, L, Poli, T, Santoro, Gp, Varazzani, A (Azienda Ospedaliero-Universitaria Di Parma), Aguzzoli, L, Borgonovo, G, Castro Ruiz, C, Coiro, S, Falco, G, Mandato, Vd, Mastrofilippo, V, Montella, Mt, Annessi, V, Zizzo M (Azienda Unit&#224, Sanitaria Locale, - Irccs Di Reggio Emilia), Grossi, U, Novello, S, Romano, M, Rossi, S, Zanus, G (Ca&#8217, Foncello Treviso-DISCOG-Universit Di Padova), Esposito, G, Frongia, F, Pisanu, A, Podda, M (Cagliari University Hospital), Belluco, C, Lauretta, A, Montori, G, Moras, L, Olivieri, M (Centro Di Riferimento Oncologico Di Aviano (Cro) Irccs), Bussu, F, Carta, Ag, Cossu, Ml, Cottu, P, Fancellu, A, Feo, Cf, Ginesu, Gc, Giuliani, G, Madonia, M, Perra, T, Piras, A, Porcu, A, Rizzo, D, Scanu, Am, Tedde, A, Tedde, M (Cliniche San Pietro, Sassari), A. o. u., Delrio, P, Rega D (Colorectal Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale-I. r. c. c. s., ), Badalamenti, G, Campisi, G, Cordova, A, Franza, M, Maniaci, G, Rinaldi, G, Toia, F (Department Of Surgical, University Of Palermo), Oncological And Oral Sciences., Calabr&#242, M, Farnesi, F, Lunghi, Eg, Muratore, A, Pipitone Federico NS (Edoardo Agnelli), B&#224, mbina, F, Andrea, G, Familiari, P, Picotti, V (Fabrizio Spaziani), De Palma, G, Luglio, G, Pagano, G, Tropeano FP (Federico Ii University Hospital), Baldari, L, Beltramini, Ga, Boni, L, Cassinotti, E, Gianni&#8217, Pignataro, L, Torretta S (Fondazione Irccs Ca&#8217, Granda, - Ospedale Maggiore Policlinico), Abatini, C, Baia, M, Biasoni, D, Bogani, G, Cadenelli, P, Capizzi, V, Cioffi, Spb, Citterio, D, Comini, Lv, Cosimelli, M, Fiore, M, Folli, S, Gennaro, M, Giannini, L, Gronchi, A, Guaglio, M, Macchi, A, Martinelli, F, Mazzaferro, V, Mosca, A, Pasquali, S, Piazza, C, Raspagliesi, F, Rolli, L, Salvioni, R, Sarpietro, G, Sarre, C, Sorrentino, L (Fondazione Irccs Istituto Nazionale Dei Tumori, Milano), Agnes, A, Alfieri, S, Belia, F, Biondi, A, Cozza, V, Amore, A, Ugo, D, De Simone, V, Fagotti, A, Gasparini, G, Gordini, L, Litta, F, Lombardi, Cp, Lorenzon, L, Marra, Aa, Marzi, F, Moro, A, Parello, A, Perrone, E, Persiani, R, Ratto, C, Rosa, F, Saponaro, G, Scambia, G, Scrima, O, Sganga, G, Tudisco, R (Fondazione Policlinico Universitario Agostino Gemelli), Belli, A, Granata, V, Izzo, F, Palaia, R, Patrone R (Hpb Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale- I. r. c. c. s., ), Carrano, Fm, Carvello, Mm, De Virgilio, A, Di Candido, F, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spinelli, A, Spriano, G (Humanitas Clinical And Research Center Irccs, Rozzano (Mi) &amp, Humanitas, University, Department Of Biomedical Sciences, Pieve Emanuele (Mi)), Donati, Dm, Frisoni, T, Palmerini, E (Irccs Istituto Ortopedico Rizzoli), Aprile, A, Barra, F, Batistotti, P, Ferrero, S, Fregatti, P, Scabini, S, Sparavigna, M (Irccs Ospedale Policlinico San Martino), Asti, E, Bernardi, D, Bonavina, L, Lovece, A (University of Milan, IRCCS Policlinico San Donato), Adamoli, L, Ansarin, M, Cenciarelli, S, Chu, F, De Berardinis, R, Fumagalli Romario, U, Mastrilli, F, Pietrobon, G, Tagliabue M (Istituto Europeo Di Oncologia, - Irccs -Milano), Badellino, E, Ferrero, A, Massobrio, R (Mauriziano Hospital Torino, Italy), De Manzoni Garberini, A (Ospedale Civile Spirito Santo), Federico, P, Maida, P, Marra, E, Marte, G, Petrillo, A, Tammaro, T, Tufo, A (Ospedale Del Mare), Berselli, M, Borroni, G, Cocozza, E, Conti, L, Desio, M, Livraghi, L, Quintodei, V, Rizzi, A, Zullo A (Ospedale Di Circolo, E Fondazione Macchi (Varese)), Baldi, C, Corbellini, C, Sampietro GM (Ospedale Di Rho, - Asst Rhodense), Cellerino P (Ospedale Fatebenefratelli, E Oftalmico), Baldini, E, Capelli, P, Isolani, Sm, Ribolla, M (Ospedale Guglielmo Da Saliceto Piacenza), Bondurri, A, Colombo, F, Ferrario, L, Guerci, C, Maffioli, A (Ospedale Luigi Sacco Milano), Armao, T, Ballabio, M, Bisagni, P, Gagliano, A, Longhi, M, Madonini, M, Pizzini, P (Ospedale Maggiore Di Lodi), Baietti, Am, Biasini, M, Maremonti, P, Neri, F, Prucher, Gm, Ricci, S, Ruggiero, F, Zarabini AG (Ospedale Maggiore/Bellaria Carlo Alberto Pizzardi Ausl Bologna), Barmasse, R, Mochet, S, Usai, A (Ospedale Regionale Umberto Parini), Leonardo - Asl Napoli 3 Sud, Incollingo P (Ospedale S., Castellammare Di Stabia), Mancini, S, Marino Cosentino, L, Sagnotta, A (Ospedale San Filippo Neri), Fruscio, R, Grassi, T, Nespoli, Lc, Tamini, N (Ospedale San Gerardo), Anastasi, A, Bartalucci, B, Bellacci, A, Canonico, G, Capezzuoli, L, Di Martino, C, Ipponi, P, Linari, C, Montelatici, M, Nelli, T, Spagni, G, Tirloni, L, Vitali, A (Ospedale San Giovanni Di Dio), Abate, E, Casati, M, Casiraghi, T, Laface, L, Schiavo M (Ospedale Vittorio Emanuele Iii, - Carate Brianza), Arminio, A, Cotoia, A, Lizzi, V, Vovola, F (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia), Vergari, R (Ospedali Riuniti Di Ancona), Ugo, S, Depalma, N, 8220, Vito Fazzi&#8221, Spampinato MG (P. o., Bartolucci, P, Brachini, G, Bruzzaniti, P, Chiappini, A, Chiarella, V, Ciccarone, F, Cicerchia, Pm, Cirillo, B, De Toma, G, Di bartolomeo, A, Fiori, E, Fonsi, Gb, Franco, G, Frati, A, Giugliano, M, Iannone, I, La Torre, F, Lapolla, P, Leonardo, C, Marruzzo, G, Meneghini, S, Mingoli, A, Ribuffo, D, Salvati, M, Santoro, A, Sapienza, P, Scafa, Ak, Simonelli, L, Zambon M (Policlinico Umberto, I Sapienza University Of Rome), Capolupo, Gt, Carannante, F, Caricato, M, Mascian&#224, G, Mazzotta, E (Policlinico Universitario Campus Bio Medico Of Rome), Gattolin, A, Migliore, M, Rimonda, R, Sasia, D, Travaglio, E (Regina Montis Regalis Hospital, Mondov&#236, Cervellera, M, Gori, A, Sartarelli, L, orsola-Malpighi Hospital), Tonini V (S., Giacometti, M, Zonta, S (Ospedale San Biagio, Asl, VCO), Chessa, A, Fiorini, A, Norcini, C (San Giovanni Di Dio), Colletti, G, Confalonieri, M, Costanzi, A, Frattaruolo, C, Mari, G, Monteleone, M (San Leopoldo Mandic), Bandiera, A, Bocciolone, L, Bonavina, G, Candiani, M, De Nardi, P, Gagliardi, F, Medone, M, Mortini, P, Negri, G, Ottolina, J, Parise, P, Piloni, M, Sileri, P, Vignali, A (San Raffaele Scientific Institute, Milan), Belvedere, A, Bernante, P, Bertoglio, P, Boussedra, S, Brunocilla, E, Cipriani, R, Cisternino, G, De Crescenzo, E, De Iaco, P, Dondi, G, Frio, F, Jovine, E, Mineo Bianchi, F, Neri, J, Parlanti, D, Perrone, Am, Pezzuto, Ap, Pignatti, M, Pinto, V, Poggioli, G, Ravaioli, M, Rottoli, M, Schiavina, R, Serenari, M, Serra, M, Solli, P, Taffurelli, M, Tanzanu, M, Tesei, M, Violante, T, Zanotti, S (Sant&#8217, orsola Hospital, Alma Mater Studiorum University Of Bologna, Borghi, F, Cianflocca, D, Di Maria Grimaldi, S, Donati, D, Gelarda, E, Geretto, P, Giraudo, G, Giuffrida, Mc, Marano, A, Palagi, S, Pellegrino, L, Peluso, C, Testa V (Santa Croce, E Carle Hospital, Cuneo), Agresta, F, Prando, D, Zese M (Santa Maria Degli Angeli Hospital Ulss5, - Adria), Aquila, F, Gambacciani, C, Lippa, L, Pieri, F, Santonocito OS (Spedali Riuniti Di Livorno), Armatura, G, Bertelli, G, Frena, A, Marinello, P, Notte, F, Patauner, S, Moritz Hospital), Scotton G (St., Fulginiti, Sf, Gallo, G, Sammarco, G, Vescio, G (University &#8216, Magna Graecia&#8217, Of Catanzaro), Balercia, P, Catarzi, L, Consorti G (University Hospital Umberto, I Ancona), Di Marzo, F (Valtiberina), Japan: Daiko H, Fontana T (Vittorio Emanuele)., Ishikawa, M, Ishiyama, K, Iwata, S, Kanematsu, K, Kanemitsu, Y, Kato, T, Kawai, A, Kobayashi, E, Kobayashi Kato, M, Moritani, K, Nakatani, F, Oguma, J, Tanase, Y, Jordan: Al Abdallah M, Uno M (National Cancer Center Hospital)., Ayasra, F, Ayasra, Y, Qasem, A (Al-Basheer Hospital), Abu Za&#8217, nouneh FJ, Fahmawee, T, Hmedat, A, Ibrahim, A, Obeidat, K (King Abdullah University Hospital), Abdel Al, S, Abdel Jalil, R, Abou Chaar MK, Al-Masri, M, Al-Najjar, H, Alawneh, F, Alsaraireh, O, Elayyan, M, Ghanem, R, Libya: Alkadeeki G (Al-Jalaa Hospital), Lataifeh I (King Hussein Cancer Center)., Aldokali, N, Senossi, O, Subhi MT (Alkhadra Hospital), Burgan, D, Kamoka, E, Kilani, Ai, Salamah, A, Salem, M, Shuwayyah, A (National Cancer Institute, Sabratha, - Libya), Abdulwahed, E, Alshareea, E, Aribi, N, Aribi, S, Biala, M, Ghamgh, R, Morgom, M (Tripoli Central Hospital), Aldayri, Z, Ellojli, I, Lithuania: Bradulskis S, Kredan A (Tripoli University Hospital)., Dainius, E, Kubiliute, E, Kutkevi&#269, ius, J, Parseliunas, A, Subocius, A, Madagascar: Rasoaherinomenjanahary F, Venskutonis D (Lithuanian University Of Health Sciences Kaunas Clinical Hospital)., Razafindrahita, Jb, Malaysia: Ong EC (Bintulu), Samison LH (Joseph Ravoahangy Andrianavalona Hospital)., Hamdan, Kh, Ibrahim, Mr, Tan, Ja, Thanapal MR (Hospital Kuala Lumpur), Amin Sahid, N, Hayati, F, Jayasilan, J, Sriram, Rk, Subramaniam, S (Queen Elizabeth Hospital &amp, Universiti Malaysia Sabah, Kota, Kinabalu, Sabah, Malaysia), Che Jusoh, A, Hussain, Ah, Mohamed Sidek AS, Mohd Yunus MF, Soh, Jy, Wong, Mpk, Zakaria, Ad, Zakaria, Z (School Of Medical Sciences &amp, Hospital, Universiti Sains Malaysia), Fadzli, A, Fathi, Nq, Koh, Ps, Liew, Yt, Roslani, Ac, Tang, Cy, Teoh, Ly, Wong, Wj, Mexico: Alvarez MR, Yahaya AS (University Malaya Medical Centre)., Arrangoiz, R, Cordera, F, De la Rosa Abaroa MA, G&#243, mez-Pedraza, A, Hernandez, R, Maffuz-Aziz, A, Posada JA (Abc Medical Center), Becerra Garc&#237, a FC (Hospital San &#193, ngel Inn Chapultepec), Alfaro-Goldaracena, A, Buerba, Ga, Castillejos- Molina RA, Chan, C, Dominguez-Rosado, I, Medina-Franco, H, Mercado, M&#225, Oropeza- Aguilar, M, Pe&#241, a G&#243, mez Portugal, E, Posadas-Trujillo, Oe, Rodriguez-Covarrubias, F, Salgado-Nesme, N, Morocco: Arkha Y, Vilatoba M (Instituto Nacional De Ciencias M&#233, dicas Y Nutrici&#243, n &#8220, Salvador Zubir&#225, n&#8221, Bechri, H, El Ouahabi, A, Oudrhiri MY (Centre Hospitalier Universitaire Ibn Sina Rabat), Derkaoui hassani F, El abbadi N (Cheikh Zaid International University Hospital), Amrani, L, Belkhadir, Zh, Benkabbou, A, Chakib, O, El Ahmadi, B, El Bouazizi, Y, Essangri, H, Ghannam, A, Majbar, Am, Mohsine, R, Netherlands: Hompes R, Souadka A (Institut National D&#8217, oncologie)., Meima-van Praag, E, Pronk, Ajm, Sharabiany, S (Amsterdam Umc, University Of Amsterdam), Grotenhuis, B, Hartveld, L, Reijers, S, Van Houdt, W (Antoni Van Leeuwenhoek Ziekenhuis), Baaij, J, Bolster-van Eenennaam, M, De Graaff, M, Sloothaak, D, Van Duijvendijk, P (Gelre Ziekenhuis), Posma-Bouman, L (Slingeland Ziekenhuis), Derksen, T, Franken, J, Oosterling, S (Spaarne Gasthuis), De Bree, R (University Medical Center Utrecht), Konsten, J, Nigeria: Fidelis L, Van Heinsbergen M (Viecuri Medisch Centrum)., Sholadoye, Tt, Tolani, M (Ahmadu Bello University Teaching Hospital), Olaogun, J (Ekiti State University Teaching Hospital), Egbuchulem, Ik, Lawal, Ta, Ogundoyin, O, Olulana DI (University College Hospital), Abdur-Rahman, L, Adeyeye, A, Aremu, I, Bello, J, Olasehinde, O, Oman: Massoud J, Popoola A (University Of Ilorin Teaching Hospital)., Massoud, R, Pakistan: Jamal A, Sorour TM (Khoula Hospital)., Kerawala AA (Cancer Foundation Hospital), Memon, As, Nafees Ahmed, R, Pfau Civil Hospital), Rai L (Dr Ruth K. m., Ayub, B, Hassan, N, Martins, Rs, Ramesh, P, Sayyed, R (Patel Hospital), Butt, U, Kashif, M, Khan, Wh, Qureshi, A, Umar, M, Waris Farooka, M, Wasim, T (Services Hospital Lahore), Ayubi, A, Rashid, I, Peru: Falcon GM, Waqar SH (The Pakistan Institute Of Medical Sciences)., Philippines: Jocson R, Robles R (Instituto Regional De Enfermedades Neopl&#225, sicas Del Sur)., Teh, C (National Kidney &amp, Poland: Major P (Jagiellonian University Medical College), Transplant Institute)., Bobi&#324, ski, M, Kotarski, J, Rasoul-Peli&#324, ska, K (Medical University Of Lublin, Portugal: Azevedo C, Chair And Department Of Gynaecological Oncology And Gynaecology)., Machado, D, Mendes, F (Centro Hospitalar Cova Da Beira), De Sousa, X (Centro Hospitalar De Set&#250, bal), Fernandes, U, Ferreira, C, Guidi, G, Leal, C, Mar&#231, al, A, Marques, R, Martins, D, Melo, A, Tenreiro, N, Vaz Pereira, R, Vieira B (Centro Hospitalar De Tr&#225, s-Os-Montes, E Alto Douro, E. p. e., ), Almeida, Ji, Correia de S&#225, T, Costa, Mjma, Fernandes, V, Ferraz, I, Gil, Cg, Lima da Silva, C, Lopes, L, Machado, N, Marialva, J, Nunes Coelho, M, Pedro, J, Pereira, C, Reis, R, Ribeiro, A, Santos, R, Saraiva, P, Silva, R, Tavares, F, Teixeira M (Centro Hospitalar Do Tamega, E Sousa), Almeida, Ac, Amaral, Mj, Andrade, R, Athayde Nem&#233, sio, R, Breda, D, Camacho, C, Canhoto, C, Colino, M, Correia, S, Costa, M, De Barros, J, De Oliveira L&#243, pez AL, Duque, M, Garrido, S, Guerreiro, P, Guimar&#227, es, A, L&#225, zaro, A, Lopes, C, Martins, R, Nogueira, O, Oliveira, A, Oliveira, Jm, Rodrigues, M, Ruivo, A, Santos, E, Silva, M, Sim&#245, es, J, Valente da Costa A (Centro Hospitalar, E Universit&#225, rio De Coimbra), Almeida, A, Cavaleiro, S, Devezas, V, Faria, Cs, J&#225, come, F, Magalh&#227, es Maia, M, Nogueiro, J, Pereira, A, Pereira-Neves, A, Pina-Vaz, T, Santos-Sousa, H, Silveira, H, Vaz, S, Vieira P (Centro Hospitalar, E Universit&#225, rio De S&#227, o Jo&#227, Gomes da Costa A, Lobo Antunes I (Centro Hospitalar Lisboa Norte), Pinto J, Tojal A (Centro Hospitalar Tondela-Viseu), Cardoso, N, Cardoso, P, Domingues, Jc, Henriques, P, Manso, Mi, Martins dos Santos, G, Morais, H, Pereira, R, Revez, T, Ribeiro, R, Ribeiro, Vi, Soares, A, Sousa, S, Teixeira J (Centro Hospitalar Universit&#225, rio Do Algarve, - Unidade De Faro), Amorim, E, Baptista, Vh, Cunha, Mf, Dias, B, Fazenda, A, Melo Neves JP, Policarpo, F, Sampaio da N&#243, voa Gomes Miguel II, Veiga D (Centro Hospitalar Universitario Do Algarve, - Unidade De Portim&#227, Andrade, Ak, Bandovas, Jp, Borges, N, Branquinho, A, Chumbinho, B, Correia, J, Fidalgo, H, Figueiredo de Barros, I, Frade, S, Gomes, J, Maciel, J, Pina, S, Rodrigues, A, Silva, N, Silveira Nunes, I, Sousa, R (Centro Hospitalar Universit&#225, rio Lisboa Central), Ascens&#227, o, J, Azevedo, P, Costeira, B, Cunha, C, Garrido, R, Gomes, H, Louren&#231, o, I, Mendinhos, G, Miranda, P, Nobre Pinto, A, Peralta Ferreira, M, Ribeiro, J, Rio Rodrigues, L, Sousa Fernandes, M (Hospital Beatriz Angelo), Azevedo J (Hospital Da Horta, E. p. e. ), Galv&#227, o, D, Soares, Ac, Vieira, A, Vieira, B (Hospital De Santo Espirito Da Ilha Terceira), Patr&#237, cio, B, Santos, Pmdd, Vieira Paiva Lopes AC (Hospital De Torres Vedras, - Centro Hospitalar Do Oeste), Cunha, R, Faustino, A, Freitas, A, Martins, Ab, Mendes, Jr, Parreira, R, Rosa, J, Teves, M (Hospital Do Divino Esp&#237, rito Santo), Abreu da Silva, A, Claro, M, Costa Santos, D, Deus, Ac, Grilo JV (Hospital Do Litoral Alentejano), Borges, F, Corte Real, J, Henriques, S, Lima, Mj, Matos Costa, P (Hospital Garcia De Orta), Brito da Silva, F, Caiado, A, Fonseca, F (Instituto Portugu&#234, s De Oncologia De Lisboa Francisco Gentil), 194, ngelo, M, Baiao, Jm, Martins Jord&#227, Vieira Caro&#231, o, T (Ipo Coimbra), Messias, J, Millan, A, Salgado, I, Santos, P (Ipo Lisboa), Ba&#237, a, C, Canotilho, R, Correia, Am, Ferreira Pinto AP, Peyroteo, M, Puerto Rico: Escobar P, Videira JF (Ipo Porto)., R&#233, union: Kassir R, Maldonado Santiago M (Instituto Gineco Oncologico)., Romania: Bezede C, Sauvat F (Chu Reunion)., Chitul, A, Ciofic, E, Cristian, D, Grama, F (Coltea Clinical Hospital), Pirtea L, Secosan C (Emergency Clinical City Hospital), Bonci, E, Gata, V, Ion Chiricuta Institute Of Oncology), Titu S (Prof. Dr., Ginghina, O, Iordache, N, Russia: Garmanova T, Iosifescu RV (Saint John Emergency Hospital)., Kazachenko, E, Markaryan, D, Rodimov, S, Tsarkov, P, Tulina, I (Clinic Of Coloproctology And Minimally Invasive Surgery, Sechenov Medical State University), Litvina, Y, Provozina, A (Immanuel Kant Baltic Federal University, Regional Clinical Hospital), Agapov, M, Galliamov, E, Kakotkin, V, Kubyshkin, V, 1050, 1072, 1084, 1083, 1086, 1074, &#1040, (Moscow Research And Educational Center, Saudi Arabia: Alshahrani M, Lomonosov Moscow State University)., Alsharif, F, Eskander, M (Aseer Central Hospital), Al Raddadi, R, Majrashi, S, Mashat, A (East Jeddah General Hospital), Akeel, N, Alharthi, M, Aljiffry, M, Basendowah, M, Farsi, A, Ghunaim, M, Khoja, A, Maghrabi, A, Malibary, N, Nassif, M, Nawawi, A, Saleem, A, Samkari, A, Trabulsi, N (King Abdulaziz University Hospital), Al Awwad, S, Alghamdi, M, Alnumani, T, Nasser, M, Said bayazeed, A (King Fahad General Hospital), Alhefdhi, A, Almalik, O, Alomair, A, Alotaibi, N, Alresaini, F, Alsalamah, R, Alsobhi, S, Mahasin, Z, Othman, E, Velagapudi, S (King Faisal Specialist Hospital), Al Habes, H, Alamri, A, Alkarak, S, Alqannas, M, Alyami, M, Alzamanan, M, Cort&#233, s Guiral, D, Elawad, A (King Khalid Hospital), AlAamer, O, Alriyees, L, Alselaim, N (King Saud Bin Abdulaziz University For Health Sciences, King Abdullah International Medical Research Center, Ministry Of National Guard, Health, Affairs, General Surgery Department., ), Abdulkareem, A, Ajlan, A, Akkour, K, Al-Habib, A, Al-Khayal, K, Alatar, A, Alburakan, A, Alhalal, H, Alhassan, B, Alhassan, N, Alobeed, O, Alsaif, A, Alsaif, F, Alshammari, S, Alshaygy, I, Barry, M, Bin Nasser, A, Bin Traiki, T, Bokhari, A, Elwatidy, S, Helmi, H, Madkhali, A, Nouh, T, Rabah, Pd, Serbia: Paunovic I, Zubaidi A (King Saud University)., Slijepcevic, N (Centre For Endocrine Surgery, Clinical Centre Of Serbia), Aleksi&#263, L, Antic, A, Barisic, G, Ceranic, M, Galun, D, Gruba&#269, &#381, Jelenkovic, J, Kecmanovi&#263, Kmezi&#263, Knezevic, D, Krivokapic, Z, Latin&#269, Markovic, V, Mati&#263, Miladinov, M, Pavlov, M, Pejovic, I, Radenkovic, D, Tadic, B, Vasljevi&#263, J, Velickovic, D, Zivanovic, M (Clinic For Digestive Surgery, Perovic M, Srbinovic L (Clinic For Gynecology And Obstetrics Narodni Front), Andrijasevic, S, Bozanovic, T, Cerovic Popovic, R, Dokic, M, Janjic, T, Jeremic, K, Kadija, S, Ladjevic Likic, I, Mirkovic, L, Pantovic, S, Pilic, I, Radojevic, M, Stefanovic, A, Vidakovic, S, Vilendecic, Z (Clinic For Gynecology And Obstetrics, Clinical Center Of Serbia), Antic, S, Dun&#273, erovi&#263, Jelovac, D, Jezdic, Z, Konstantinovic, V, Kotlar, B, Kuzmanovic, C, Lazi&#263, Petrovic, M, Popovic, F, Pucar, A, Romic, M, Sumrak, S, Vujanac, V (Clinic For Maxillofacial Surgery, School Of Dental Medicine, University Of Belgrade), Bascarevic, V, Bogdanovi&#263, I, Gruji&#269, Ilic, R, Mili&#263, evi&#263, Milisavljevi&#263, F, Miljkovi&#263, Paunovic, A, 352, 263, epanovi&#263, V, Stanimirovic, A, Todorovic, M (Clinic For Neurosurgery, Jotic, A, Milovanovic, J, Trivic, A (Clinic For Otorhinolaryngology And Maxillofacial Surgery, Bumbasirevic, U, Dzamic, Z, Kajmakovi&#263, B, Prijovi&#263, N, Zivkovic, M (Clinic Of Urology, Buta, M, Cvetkovic, A, Djurisic, I, Gacic, S, Goran, M, Inic, Z, Jeftic, N, Jevric, M, Jokic, V, Markovic, I, Milanovi&#263, Nikolic, S, Pejnovic, L, Savkovi&#263, Spurnic, I, Stevic, D, Stojiljkovic, D, Vucic, N, Zegarac, M (Institute For Oncology And Radiology Of Serbia), Karamarkovic, A, Kenic, M, Kovacevic, B, Krdzic, I, Singapore: Chan CW, Milutinovi&#263, V (Zvezdara University Medical Center)., Slovakia: G&#225, lis B, Lieske B (National University Hospital)., South Africa: Almgla N, &#352, imko K (University Hospital Bratislava)., Bernon, M, Boutall, A, Cairncross, L, Herman, A, Hilton, T, Jonas, E, Kloppers, C, Malherbe, F, Mugla, W, Nel, D, Rayamajhi, S, Van Wyngaard, T, Spain: Casta&#241, o-Leon AM, Vogel J (Groote Schuur Hospital)., Delgado Fernandez, J, Eiriz Fernandez, C, Espino Segura-Illa, M, Esteban Sinovas, O, Garcia Perez, D, Gomez, P, Jimenez-Roldan, L, Lagares, A, Moreno- Gomez, L, Paredes, I, P&#233, rez N&#250, 241, ez, A, S&#225, nchez Aniceto, G, Santas, M (12 De Octubre University Hospital), Fern&#225, ndez Rodr&#237, guez, P, Paniagua Garc&#237, a Se&#241, orans, M, Sanchez- Santos, R, Vigorita, V (&#193, lvaro Cunqueiro Hospital), Acrich, E, Baena Sanfeliu, E, Barrios, O, Golda, T, Santanach, C, Serrano-Navidad, M, Sorribas Grifell, M, Vives RV (Bellvitge University Hospital), Escol&#224, D, Jim&#233, nez A (Comarcal Alt Pened&#233, Cayetano Paniagua L, G&#243, mez Fern&#225, ndez L (Consorci Sanitari De Terrassa), Artigues, E, Bernal-Sprekelsen, Jc, Catal&#225, Bauset JC (Consorcio Hospital General Universitario), Collera, P, Diaz Del Gobbo, R, Farre Font, R, Flores Clotet, R, mez D&#237, az CJ, Gu&#224, rdia, N, Guariglia, Ca, Osorio, A, Sanchez Jimenez, R, Sanchon, L, Soto Montesinos C (Fundaci&#243, Althaia, - Xarxa Assistencial Universit&#224, ria De Manresa), Albi Martin B, Garc&#237, a Villayz&#225, n JE (Fundaci&#243, n Jimenez Diaz University Hospital), Alonso-Lamberti, L, Assaf, M, Baeza Pintado, N, Carabias, A, a-Quijada, J, Huertas Fernandez MA, Jimenez Miram&#243, n, J, Jimenez, V, Jover, Jm, Landeo Ag&#252, ero SA, Leon, R, Mart&#237, n Salamanca MB, rez Sim&#243, n, V, Ponce, S, Rodriguez, Jl, Salazar, A, Valle Rubio, A (Getafe University Hospital), Aguado, H (Hell&#237, n Hospital), Aldecoa Ansorregui, I, Bravo Infante, R, De Lacy FB, Di Somma, A, D&#237, az-Feijoo, B, Ense&#241, at Nora, J, Fabregas, N, Ferr&#233, s, A, Gil Iba&#241, ez, B, Gonzalez Sanchez JJ, Gracia, I, Hoyos Castro JA, Lacy, Am, Langdon, C, Mombl&#225, n, D, Morales, X, Oleaga, L, Otero, A, Pedrosa, L, Poblete Carrizo, J, Reyes Figueroa LA, Roldan Ramos, P, Rumia-Arboix, J, Tercero-Uribe, Ai, Topczewski, Te, Torales, J, Torne, A, Torn&#233, R, Turrado-Rodriguez, V, Valero, R, Valverde, S (Hospital Clinic Barcelona), Anula, R, Cano-Valderrama, O, Del Campo Mart&#237, n, M, ez-Valladares, L, Dom&#237, nguez, I, Dziakova, J, a Alonso, M, a Romero, E, mez Latorre, L, Muguerza, Jm, Pizarro, Mj, Saez Carlin, P, nchez del Pueblo, C, nchez-Pernaute, A, Sanz Ortega, G, Sanz-Lopez, R, Torres, A (Hospital Cl&#237, nico De Madrid), Garc&#233, s-Albir, M, Lopez, F, n-Ar&#233, valo, J, Moro-Valdezate, D, Pla-Marti, V (Hospital Cl&#237, nico Universitario De Valencia), Beltr&#225, n de Heredia, J, De Andr&#233, s Asenjo, B, mez Sanz, T, Jezieniecki, C, Nu&#241, ez Del Barrio, H, Ortiz de Sol&#243, rzano Aurusa FJ, Romero de Diego, A, Ruiz Soriano, M, Trujillo D&#237, az, J, Vazquez fernandez, A (Hospital Cl&#237, nico Universitario De Valladolid), Lora-Cumplido P, Sosa MV (Hospital De Cabue&#241, es), Gonzalez-Gonzalez E, Minaya Bravo AM (Hospital Del Henares), Alonso de la Fuente, N, Cazador Labat, M, Cecchini, L, Espinosa, Ca, Jimenez Toscano, M, L&#243, pez Campillo, A, Mancebo, G, Martorell, P, Munarriz, M (Hospital Del Mar), Grau-Talens EJ, Martin-Perez B (Hospital Don Benito-Villanueva), Benavides Buleje JA, Carrasco Prats, M, ndez, Pv, ndez-L&#243, pez, A, a Escudero, D, a Porcel VJ, Garcia Soria, V, Gim&#233, nez Franc&#233, s, C, Gonz&#225, lez Valverde FM, Gurrea, E, pez-Morales, P, Marco Garrido, A, nez Alonso JA, Medina, E, Mu&#241, oz Camarena JM, Parra Ba&#241, os PA, a Ros, E, Ramirez Faraco, M, Ruiz-Mar&#237, Sanchez Rodriguez, C, Valero Soriano, M (Hospital General Reina Sof&#237, Estaire G&#243, mez, M, ndez Camu&#241, as, &#193, Garcia Santos EP, Jimenez Higuera, E, nez-Pinedo, C, oz-Atienza, V, Padilla-Valverde, D, Pic&#243, n Rodr&#237, guez, R, Redondo Calvo FJ, nchez-Garc&#237, a, S, Sanchez-Pelaez, D (Hospital General Universitario De Ciudad Real), Colombari, Rc, Del valle, E, ndez, M, Lozano Lominchar, P, n, L, Rey Valcarcel, C, Steiner, Ma, Tudela, M, Zorrilla Ort&#250, zar, J (Hospital General Universitario Gregorio Mara&#241, 243, Alcaide Matas, F, a P&#233, rez JM, Troncoso Pereira, P (Hospital Mateu Orfila), Mora-Guzm&#225, n, I (Hospital Santa B&#225, rbara), Abell&#225, Achalandabaso Boira, M, Jorba, R, Memba Ikuga, R, Olona, C, Sales Mallafr&#233, R (Hospital Universitari De Tarragona Joan Xxiii), Cavall&#233, Busquets, P, Gavalda Pellice MGP, Salinas Pe&#241, a, J (Hospital Universitari Sant Joan), Aragon Achig EJ, Barbier, L, Caja Vivancos, P, Gainza, A, a Gutierrez JJ, Mallabiabarrena Ormaechea, G, Mar&#237, n, H, Martin Playa, P, Melchor Corc&#243, stegui, I, Prieto Calvo, M, Rodriguez Fraga, A, Villalabeitia Ateca, I (Hospital Universitario Cruces), De Andres Olabarria, U, Dur&#225, n Ballesteros, M, ndez Pablos FJ, Ib&#225, ez-Aguirre, Fj, Sanz Larrainzar, A, Ugarte-Sierra, B (Hospital Universitario De Galdakao), De la Hoz Rodr&#237, guez, &#193, Di Martino, M, a Septiem, J, Martin-Perez, E, oz de Nova JL (Hospital Universitario De La Princesa), Calvo Espino P, Guillamot Ruano P (Hospital Universitario De M&#243, stoles), Colao Garc&#237, a, L, az P&#233, rez, D, Esteban Agust&#237, E, Galindo Jara, P, Gutierrez Samaniego, M, Hernandez Bartolome MA, Serrano Gonz&#225, lez, J (Hospital Universitario De Torrej&#243, n De Ardoz), Alonso Poza, A, Di&#233, guez, B, a-Conde, M, Hern&#225, ndez-Garc&#237, a, M, Losada, M (Hospital Universitario Del Sureste), Chiesa-Estomba, Cm, lez Garc&#237, a J&#193, Larruscain, E, Sistiaga-Su&#225, rez JA (Hospital Universitario Donostia), Alvarez, E, Chavarrias, N, Fr&#237, as, L, a Pineda, V, Geg&#250, ndez Sim&#243, n, A, Gort&#225, zar, S, Gracia, M, Guevara, J, ndez Gutierrez, A, Loayza, A, a Dolores DT, C, Melendez, M, Moreno-Palacios, E, Perez, Y, Prieto Nieto MI, Ramos- Mart&#237, n, P, Rubio-Perez, I, Saavedra, J, Sanchez-Mendez, Ji, Siegrist Ridruejo, J, Urbieta, A, Zapardiel, I (Hospital Universitario La Paz), Cantalejo diaz, M, De Miguel Ardevines MDC, Duque-Mall&#233, Gascon Ferrer, I, lez-Nicol&#225, s Tr&#233, bol MT, Gracia-Roche, C, Herrero Lopez, M, Jariod Ferrer UM, Lanzon, A, Martinez German, A, Matute, M, Redondo, C, nchez Fuentes, N, nchez-Rubio, M, Santero-Ramirez, Ms, Saud&#237, Sim&#243, n Sanz MV, Uson-Bouthelier, T (Hospital Universitario Miguel Servet), Blazquez Martin, A, Diez Alonso, M, a Rico, E, Garcia-Loarte Gomez, E, Garcia-Moreno Nisa, F, Gutierrez Calvo, A, Hernandez, P, Lasa, I, Mendoza-Moreno, F, Morales Palacios, N, Ovejero Merino, E, Vera Mansilla, C (Hospital Universitario Principe De Asturias), Acebes Garc&#237, a, F, Bail&#243, Bueno Ca&#241, ones AD, Choolani Bhojwani, E, Marcos-Santos, P, Miguel, T, Pacheco S&#225, nchez, D, rez-Saborido, B, Sanchez Gonzalez, J, Tejero-Pintor FJ (Hospital Universitario R&#237, o Hortega), Alconchel, F, Conesa, A, Gil Mart&#237, nez, J, Guti&#233, rrez Fern&#225, ndez AI, Lopez Abad, A, Nicol&#225, s-L&#243, pez, T, Ramirez Romero, P, Roca Calvo MJ, Rodrigues, K, Ruiz Manzanera JJ, Soriano AI (Hospital Universitario Virgen De La Arrixaca), Cano, A, Capitan-Morales, L, Cintas Catena, J, Gomez-Rosado, J, Oliva Mompean, F, rez S&#225, nchez MA, R&#237, o Lafuente FD, Torres Arcos, C, Valdes-Hernandez, J (Hospital Universitario Virgen Macarena), Cholewa, H, Domingo, S, Frasson, M, Lago, V, Marina Martin, T, nez Chicote, C, Sancho-Muriel J (Hospital Universitario, Y Polit&#233, cnico La Fe), Landaluce-olavarria A, Lecumberri D (Hospital Urduliz), Abad Gurumeta, A, Abad-Motos, A, nez-Hurtado, E, Ripoll&#233, s-Melchor, J, Ruiz Escobar, A (Infanta Leonor University Hospital), Cuadrado- Garc&#237, a, A, Garcia-Sancho Tellez, L, Heras Aznar, J, Mat&#233, P, Ortega V&#225, zquez, I, Picardo, Al, Rojo L&#243, pez JA, Sanchez Cabezudo Noguera, F, Serralta de Colsa, D (Infanta Sof&#237, a University Hospital), Anchuelo Latorre, J, Cagigas Fernandez, C, Cai&#241, a Ruiz, R, Gomez Ruiz, M, Hernanz, F, Jimeno Fraile, J, nez-P&#233, rez, P, Poch, C, Santarrufina Martinez, S, Valbuena Jabares, V (Marqu&#233, s De Valdecilla University Hospital), Moliner-S&#225, nchez, C, Pingarron-Martin, L, Rey-Biel, J, Ruiz Martin, I (Rey Juan Carlos University Hospital), Blas Laina JL, Cros, B, Escartin, J, Garcia Egea, J, Nogu&#233, Talal El-Abur, I, Y&#225, nez, C (Royo Villanova), Cagigal Ortega EP, Cervera, I, az Pe&#241, a, P, Elena, Gdcr, Enjuto, D, ndez Bernab&#233, s Garc&#237, a, R, Gonzalez, J, ndez, I, Herrera-Merino, N, Marqueta De Salas, M, Martinez Pascual, P, Perez Gonzalez, M, Ramos Bonilla, A, Rodr&#237, guez G&#243, mez, L (Severo Ochoa University Hospital), Besc&#243, Blanco-Colino, R, Brana, I, Caimari, B, De Pablo Garc&#237, a-Cuenca, A, Duran-Valles, F, Espin-Basany, E, Giralt L&#243, pez de Sagredo, J, Pamias, J, Pellino, G, Prat, N, Pujol Pina, R, Sri Lanka: Arulanantham A, Saez barba M (Vall D&#8217, hebron University Hospital)., Bandara, Gbk, Jayarajah, U, Ravindrakumar, S, Rodrigo VS (District General Hospital Chilaw), Srishankar S (Teaching Hospital Anuradhapura). Sudan: Ali karar AA (Al-Rajhi). Sweden: Elbe P, Lindqvist EK (Karolinska University Hospital), Taflin, H (Sahlgrenska University Hospital), 196, lg&#229, Heinius, G, Nordberg, M, Pieniowski, E (South General Hospital), Gkekas, I, fgren, N, Ruteg&#229, rd, M, Switzerland: Arigoni M, Sund M (Umea University Hospital)., Bernasconi, M, Christoforidis, D, Di Giuseppe, M, La Regina, D, Mongelli, F (Ente Ospedaliero Cantonale), Chevallay, M, Dwidar, O, Gialamas, E, Sauvain, M (Hopital De Pourtales), Klenke, F, Koll&#224, r, A, Kurze, C (Inselspital, Bern University Hospital, University Of Bern), Adamina, M, B&#228, chler, T, Crugnale, As, Giardini, M, Guglielmetti, L, Peros, G, Turkey: Aghayeva A, Solimene F (Kantonsspital Winterthur)., Hamzaoglu, I, Sahin, I (Acibadem Altunizade Hospital), Akaydin, E, Aliyeva, Z, Aytac, E, Baca, B, D&#252, lgero&#287, lu, O, Ozben, V, Ozmen, Bb, Uras, C (Acibadem Atakent Hospital), Arikan, Ae, Bilgin, Ia, Bozk&#305, rl&#305, Ceyhan, Go, Kara, H, Karahasano&#287, lu, T, Uras, C (Acibadem Maslak Hospital), Celik, H (Adana Baskent University), Meydanli MM (Ankara City Hospital), Akilli, H, Ayhan, A, Kuscu, E (Baskent University), Onan MA (Gazi University Medical Faculty Hospital), Akgor, U, Dincer, Ha, Erol, T, Gultekin, M, Orhan, N, Ozgul, N, Salman, Mc, Soyak, B (Hacettepe University Hospital), Alhamed, A, Erg&#252, n, S, OZcel&#305, k, Mf, Sanli, An, Uluda&#287, Velidedeoglu, M, Zengin AK (Istanbul Universty, - Cerrahpa&#351, a Medical Faculty), Bozkurt, Ma, Kara, Y, Kocata&#351, A (Kanuni Sultan Suleyman Training And Research Hospital), Cimenoglu, B, Demirhan, R, Lutfi Kirdar Training And Research Hospital), Saracoglu K (Kartal Dr., Azamat, I&#775, f, Balik, E, Bu&#287, ra, D, Giray, B, Kulle, Cb, Taskiran, C, Vatansever, D (Ko&#231, University Medical School), G&#246, zal, K, G&#252, ler, Sa, ken, H, Tatar, Oc, Utkan, Nz, Y&#305, ld&#305, r&#305, m, A, Y&#252, ksel, E (Kocaeli University Teaching Hospital), Akin, E, Altintoprak, F, Bayhan, Z, Cakmak, G, 199, apo&#287, lu, R, elebi, F, Demir, H, Dikicier, E, Firat, N, n&#252, ll&#252, Kamburo&#287, lu, Mb, Kocer, B, 231, 252, k, If, Mantoglu, B (Sakarya University Faculty Of Medicine), olak, E, Kucuk, Go, Uyanik MS (Samsun Training And Research Hospital), 304, lhan Varank Training And Research Hospital), G&#246, ksoy B (Sehit Prof. dr., Bozkurt, E, Citgez, B, Mihmanli, M, Tanal, M, Yetkin, G (Sisli Hamidiye Etfal Training And Research Hospital), Akalin, M, Arican, C, Avci, Ek, Aydin, C, Demirli At&#305, c&#305, Emiroglu, M, Kaya, T, Kebab&#231, 305, Kilinc, G, Kirmizi, Y, 287, c&#252, H, Salimo&#287, lu, S, Sert, I&#775, Tugmen, C, Tuncer, K, Uslu, G, Ye&#351, ilyurt, D (University Of Health Sciences Tepecik Training And Research Hospital), Karaman, E, Kolusar&#305, A (Van Yuzuncu Yil University, Medical, Faculty), Uganda: Benson O, Yildiz A (Yildirim Beyazit University Yenimahalle Training And Research Hospital)., United Kingdom: Agilinko J, Lule H (Kampala International University Teaching Hospital)., Ahmeidat, A, Barabasz, M, Bekheit, M, Cheung, Lk, Colloc, T, Cymes, W, Elhusseini, M, Gradinariu, G, Hannah, A, Kamera, Bs, Mignot, G, Shaikh, S, Sharma, P (Aberdeen Royal Infirmary), Abu-Nayla, I, Agrawal, A, Al-Mohammad, A, Ali, S, Ashcroft, J, Azizi, A, Baker, O, Balakrishnan, A, Byrne, M, Colquhoun, A, Cotter, A, Coughlin, P, Davies, Rj, Durrani, A, Elshaer, M, Fordington, S, Forouhi, P, Georgiades, F, Grimes, H, Habeeb, A, Hudson, V, Hutchinson, P, Irune, E, Jah, A, Khan, Dz, Kolias, A, Kyriacou, H, Lamb, B, Liau, S, Luke, L, Mahmoud, R, Mannion, R, Masterson, L, Mitrofan, Cg, Mohan, M, Morris, A, Murphy, S, Neill, R, Price, S, Pushpa-rajah, J, Raby-Smith, W, Ramzi, J, Rooney, S, Santarius, T, Singh, A, Stewart, Gd, Tan, Xs, Townson, A, Tweedle, E, Walker, C, Waseem, S, Yordanov, S (Addenbrooke&#8217, Jones, T, Kattakayam, A, Loh, C, Lunevicius, R, Pringle, S, Schache, A, Shaw, R, Sheel, A (Aintree University Hospital), Rossborough, C (Altnagelvin Area Hospital), Angelou, D, Choynowski, M, McAree, B, McCanny, A, Neely, D (Antrim Area Hospital- Northern Health And Social Care Trust), Tutoveanu, G (Barnsley Hospital Nhs Foundation Trust), Ahad, S, De La Cruz Monroy MFI, Mosley, F, Oktseloglou, V (Bradford Royal Infirmary), Alanbuki, A, Patel, M, Shabana, A (Brighton And Sussex Nhs Trust, Princess Royal Hospital), Perera, E, Raveendran, D, Ravi- Shankar, K, Thiruchelvam, J (Broomfield Hospital), Arrowsmith L, Campbell W (Causeway Hospital), Grove, T, Kontovounisios, C, Warren, O (Chelsea And Westminster Hospital), Rolland, P (Cheltenham General Hospital), Aggarwal, A, Brown, S, Jelley, C, Neal, N (Churchill Hospital), Clifford, R, Eardley, N, Krishnan, E, Manu, N, Martin, E, Roy Mahapatra, S, Serevina, Ol, Smith, C, Vimalachandran, D (Countess Of Chester Hospital), Bordenave, M, Houston, R, Putnam, G, Robson, A, Tustin, H (Cumberland Infirmary), Emslie, K, Labib, Pl, Marchbank, A, Miller, D, Minto, G, Natale, J, Nwinee, H, Panahi, P, Rogers, L (Derriford Hospital), Abubakar, A, Akhter Rahman MM, Kyk, Ko, Brien, H, Sasapu, K, Woodun, H (Diana Princess Of Wales Hospital Grimsby), Inglis R, Ng HJ (Dumfries And Galloway Royal Infirmary), De Gea Rico, A, Ghazali, N, Lambert, J, Markose, G, Math, S, Sarantitis, I, Shrestha, D, Sultana, A, Taggarsi, M, Timbrell, S, Vaz, Op, Vitone, L (East Lancashire Hospitals Nhs Trust), Day, A, Dent, H, Fahim, M, Waheed, S (East Surrey Hospital), Hunt A, Laskar N (East Sussex Healthcare (Conquest Hospital And Eastbourne District General Hospital)), Gupta, A, Steinke, J, Thrumurthy, S (Epsom &amp, St Helier University Hospitals Nhs Trust), Massie, E, McGivern, K, Rutherford, D, Wilson, M (Forth Valley Royal Hospital), Hardie J, Kazzaz S (Frimley Health Nhs Ft - Frimley Park), Handa, S, Kaushal, M, Kler, A, Patel, P, Redfern, J, Tezas, S (Furness General Hospital), Aawsaj, Y, Amonkar, S, Blackwell, L, Blake, D, Carter, J, Emerson, H, Fisher, A, Katory, M, Korompelis, P, McCormick, W, Mustafa, A, Pearce, L, Ratnavelu, N, Reehal, R (Gateshead Health Nhs Foundation Trust), Kretzmer, L, Lalou, L, Manku, B, Parwaiz, I, Stafford, J (George Eliot Hospital), Abdelkarim, M, Asqalan, A, Gala, T, Ibrahim, S, Maw, A, Mithany, R, Morgan, R, Sundaram Venkatesan, G (Glan Clwyd Hospital), Ang, K, Caruana, Ej, Chowdhry, Mf, Mohammad, A, Nakas, A, Rathinam, S (Glenfield Hospital), Boal, M, Brown, O, Dwerryhouse, S, Higgs, S, Vallance, A (Gloucestershire Royal Hospital), Boyd, E, Irvine, V, Kirk, A (Golden Jubilee National Hospital), Bakolas, G, Boulton, A, Chandock, A, Khan, T, Kumar, M (Good Hope Hospital), Agoston, P, Bill&#232, Challacombe, B, Fraser, S, Harrison-Phipps, K, King, J, Mehra, G, Mills, L, Najdy, M, Nath, R, Okiror, L, Pilling, J, Rizzo, V, Routledge, T, Sayasneh, A, Stroman, L, Wali, A (Guy&#8217, Fehervari, M, Fotopoulou, C, Habib, N, Hamrang-Yousefi, S, Jawad, Z, Jiao, L, Pai, M, Ploski, J, Rajagopal, P, Saso, S, Sodergren, M, Spalding, D (Hammersmith Hospital), Laws, S (Hampshire Hospitals Nhs Trust), Hardie C, McNaught C (Harrogate District Hospital), Alam, R, Budacan, A, Cahill, J, Kalkat, M, Karandikar, S, Kenyon, L, Naumann, D, Patel, A (Heartlands Hospital), Ayorinde, J, Chase, T, Cuming, T, Ghanbari, A, Humphreys, L, Tayeh, S (Homerton University Hospital), Aboelkassem Ibrahim, A, Bichoo, R, Cao, H, Chai, Akw, Choudhury, J, Evans, C, Fitzjohn, H, Ikram, H, Langstroth, M, Loubani, M, McMillan, A, Nazir, S, Qadri, Ssa, Robinson, A, Ross, E, Sehgal, T, Wilkins, A (Hull University Teaching Hospitals Nhs Trust), Dixon, J, Dunning, J, Freystaetter, K, Jha, M, Lester, S, Madhavan, A, Thulasiraman, Sv, Viswanath, Y (James Cook University Hospital), Curl-Roper, T, Delimpalta, C, Liao, Ccl, Velchuru, V, Westwood, E (James Paget Univeristy Nhs Foundation Trust Hospital), Belcher, E, Bond-Smith, G, Chidambaram, S, Di Chiara, F, Fasanmade, K, Fraser, L, Fu, H, Ganau, M, Gore, S, Graystone, J, Jeyaretna, D, Khatkar, H, Lami, M, Maher, M, Mastoridis, S, Mihai, R, Piper, R, Prabhu, S, Risk, Obf, Selbong, U, Shah, K, Smillie, R, Soleymani majd, H, Sravanam, S, Stavroulias, D, Tebala, Gd, Vatish, M, Verberne, C, Wallwork, K, Winter, S (John Radcliffe Hospital), Bhatti, Mi, Boyd-Carson, H, Elsey, E, Gemmill, E, Herrod, P, Jibreel, M, Lenzi, E, Saafan, T, Sapre, D, Sian, T, Watson, N (King&#8217, s Mill Hospital), Athanasiou, A, Bourke, G, Bradshaw, L, Brunelli, A, Burke, J, Coe, P, Costigan, F, Elkadi, H, Ho, M, Johnstone, J, Kanatas, A, Kantola, V, Kaufmann, A, Laios, A, Lam, S, MacInnes, E, Munot, S, Nahm, C, Otify, M, Pompili, C, Smith, I, Theophilou, G, Toogood, G, Wade, R, Ward, D, West, C (Leeds Teaching Hospitals Trust), Annamalai, S, Ashmore, C, Boddy, A, Hossain, T, Kourdouli, A (Leicester Royal Infirmary), Gvaramadze, A, Jibril, A, Prusty, L, Thekkinkattil, D (Lincoln County Hospital), Harky A, Shackcloth M (Liverpool Heart And Chest Hospital), Askari, A, Cirocchi, N, Kudchadkar, S, Patel, K, Sagar, J, Shaw, S, Talwar, R (Luton And Dunstable University Hospital), Abdalla, M, Edmondson, R, Ismail, O, Jones, D, Newton, K, Stylianides, N (Manchester Royal Infirmary), Aderombi, A, Andaleeb, U, Bajomo, O, Beatson, K, Garrett, W, Mehmood, M, V (Medway Hospital), Ng, Al-Habsi, R, Divya, Gs, Keeler, B (Milton Keynes University Hospital), Al- Sarireh, B, Egan, R, Harries, R, Henry, A, Kittur, M, Li, Z, Parkins, K, Soliman, F, Spencer, N, Thompson, D (Morriston Hospital Swansea), Burgess, C, Gemmell, C, Grieco, C, Hollyman, M, Hunt, L, Morrison, J, Ojha, S, Ryan, N (Musgrove Park Hospital), Abbadessa, F, Barnard, S, Dawe, N, Hammond, J, Mahmoud Ali, F, McPherson, I, Mellor, C, Moir, J, Pandanaboyana, S, Powell, J, Rai, B, Roy, C, Sachdeva, A, Saleh, C, Tingle, S, Williams T (Newcastle Upon Tyne Hospitals Nhs Foundation Trust., ), Manickavasagam, J, McDonald, C, McGrath, N, McSorley, N, Ragupathy, K, Ramsay, L, Solth, A (Ninewells Hospital), Kakisi, O, Seebah, K, Shaikh, I, Sreedharan, L, Youssef, M (Norfolk And Norwich University Hospital), Shah, J (North Manchester General Hospital), Ameerally, P (Northampton General Hospital), McLarty, N, Mills, S, Shenfine, A (Northumbria Nhs Hospital Trust), Sahnan, K (Northwick Park Hospital), Abu, J, Addae-Boateng, E, Bratt, D, Brock, L, Burnside, N, Cadwell-Sneath, S, Gajjar, K, Gan, C, Grundy, C, Hallam, K, Hassell, K, Hawari, M, Joshi, A, Khout, H, Konstantinidi, K, Lee, Rxn, Nunns, D, Schiemer, R, Walton, T, Weaver, H, Whisker, L, Williamson, K (Nottingham City Hospital), McVeigh, J, Myatt, R, Williams MA (Nuffield Orthopaedic Centre), Kaur, R, Leung, E, Sundar, S (Pan- Birmingham Gynaecological Cancer Centre), Michel, M, Patil, S, Ravindran, S, Sarveswaran, J, Scott, L (Pinderfields Hospital), Edmond M, King E (Poole Hospital), Almond, M, Bhangu, A, Breik, O, Cato, Ld, Desai, A, Ford, S, Griffiths, E, Idle, M, Kamal, M, Kisiel, A, Kulkarni, R, Mak, Jkc, Martin, T, Nankivell, P, Parente, A, Parmar, S, Pathanki, Am, Phelan, L, Praveen, P, Saeed, S, Sharma, N, Singh, J, Tirotta, F, Vijayan, D (Queen Elizabeth Hospital Birmingham), Geddes, A, McCaul, J, McMahon, J (Queen Elizabeth University Hospital), Khan, Ah, Khan, F, Mansuri, A, Mukherjee, S, Sarigul, M, Singh, S, Tan, Kl, Woodham, A (Queen&#8217, s Hospital Romford), Adiamah, A, Brewer, H, Chowdhury, A, Evans, J, Humes, D, Jackman, J, Koh, A, Lewis-Lloyd, C, Oyende, O, Reilly, J, Worku, D (Queens Medical Centre), Cool, P, Cribb, G, Shepherd, K (Robert Jones And Agnes Hunt Orthopaedic Hospital), Bisset C, Moug S (Royal Alexandra Hospital), Elson, N, Faulkner, G, Saleh, P, Underwood, C (Royal Bolton Hospital), Brixton, G, Findlay, L, Klatte, T, Majkowska, A, Manson, J, Potter, R (Royal Bournemouth Hospital), Bhalla, A, Chia, Z, Daliya, P, Goyal, A, Grimley, E, Hamad, A, Kumar, A, Malcolm, Fl, Theophilidou, E (Royal Derby Hospital), Bowden, J, Campain, N, Daniels, I, Fowler, G, John, J, Massey, L, McDermott, F, McGrath, J, McLennan, A, Ng, M, Pascoe, J, Rajaretnam, N (Royal Devon And Exeter Hospital), Bulathsinhala, S, Davidson, B, Fusai, G, Hidalgo Salinas, C, Machairas, N, Pissanou, T, Pollok, Jm, Raptis, Da, Soggiu, F, Tzerbinis, H, Xyda SE (Royal Free Hospital), Beamish, A, Davies, E, Foulkes, R, Magowan, D, Nassa, H, Ooi, R, Price, C, Smith, L, Solari, F, Tang, A, Williams, G (Royal Gwent Hospital), Al-Tamimi, Y, Bacon, A, Beasley, N, Chew, D, Crank, M, Ilenkovan, N, Macdonald, M, Narice, B, Rominiyi, O, Thompson, A, Varley, I (Royal Hallamshire Hospital), Drake, T, Harrison, E, Linder, G, Mayes, J, McGregor, R, Skipworth, R, Zamvar, V (Royal Infirmary Of Edinburgh), Hawkin, P, Raymond, T, Ryska, O (Royal Lancaster Infirmary), Baron, R, Dunne, D, Gahunia, S, Halloran, C, Howes, N, McKinney, R, McNicol, F, Russ, J, Szatmary, P, Tan, Jr, Thomas, A, Whelan, P (Royal Liverpool University Hospital), Anzak, A, Banerjee, A, Fuwa, O, Hughes, F, Jayasinghe, Jd, Knowles, C, Kocher, H, Leal Silva, I, Ledesma, Fs, Minicozzi, A, Navaratne, L, Rahman, R, Ramamoorthy, R, Sohrabi, C, Thaha, M, Thakur, B, Venn, M, Yip, V (Royal London Hospital), Baumber R, Parry J (Royal National Orthopaedic Hospital), Evans, S, Jeys, L, Morris, G, Parry, M, Stevenson, J (Royal Orthopaedic Hospital), Ahmadi, N, Aresu, G, Barrett-Brown, Zm, Coonar, As, Durio Yates, H, Gearon, D, Hogan, J, King, M, Peryt, A, Pradeep, Is, Smith, C (Royal Papworth Hospital), Adishesh, M, Atherton, R, Baxter, K, Brocklehurst, M, Chaudhury, M, Krishnamohan, N, McAleer, J, Owens, G, Parkin, E, Patkar, P, Phang, I (Royal Preston Hospital), Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Thomas, M, Zakai, D (Royal Stoke University Hospital), Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, Madhuri, Tk, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D (Royal Surrey County Hospital), Aljanadi, F, Jones, M, Mhandu, P, Donnell, C, Turkington, R (Royal Victoria Hospital, Belfast), Al-Ishaq, Z, Bhasin, S, Bodla, As, Burahee, A, Crichton, A, Fossett, R, Pigadas, N, Rahman, E, Snee, D, Vidya, R, Yassin, N (Royal Wolverhampton Nhs Trust), Fountain, D, Hasan, Mt, Karabatsou, K, Laurente, R, Pathmanaban, O (Salford Royal Hospital), Al-mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E (Sheffield Teaching Hospital Nhs Foundation Trust), Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R (South Warwickshire Nhs Foundation Trust), Ethunandan, M, Sekhon, Gk, Shields, H, Singh, R, Wensley, F (Southampton General Hospital), Lawday S, Lyons A (Southmead Hospital), Abbott, T, Anwar, S, Ghufoor, K, Sohrabi, C (St Bartholomew&#8217, s Hospital (Non-Cardiac Unit)), Chung, E, Hagger, R, Hainsworth, A, Karim, A, Owen, H, Ramwell, A, Williams, K (St George&#8217, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W (St Thomas&#8217, Hospital), 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T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone Federico, N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De Palma, G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni, A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Cioffi, S. P. B., Citterio, D., Comini, L. V., Cosimelli, M., Folli, S., Gennaro, M., Giannini, L., Gronchi, A., Guaglio, M., Macchi, A., Martinelli, F., Mazzaferro, V., Mosca, A., Pasquali, S., Piazza, C., Raspagliesi, F., Rolli, L., Salvioni, R., Sarpietro, G., Sarre, C., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., D'Amore, A., D'Ugo, D., De Simone, V., Fagotti, A., Gasparini, G., Gordini, L., Litta, F., Lombardi, C. P., Lorenzon, L., Marra, A. A., Marzi, F., Moro, A., Parello, A., Perrone, E., Persiani, R., Ratto, C., Rosa, F., Saponaro, G., Scambia, G., Scrima, O., Sganga, G., Tudisco, R., Belli, A., Granata, V., Izzo, F., Palaia, R., Patrone, R., Carrano, F. M., Carvello, M. M., De Virgilio, A., Di Candido, F., Ferreli, F., Gaino, F., Mercante, G., Rossi, V., Spinelli, A., Spriano, G., Donati, D. M., Frisoni, T., Palmerini, E., Aprile, A., Barra, F., Batistotti, P., Ferrero, S., Fregatti, P., Scabini, S., Sparavigna, M., Asti, E., Bernardi, D., Bonavina, L., Lovece, A., Adamoli, L., Ansarin, M., Cenciarelli, S., Chu, F., De Berardinis, R., Fumagalli Romario, U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino Cosentino, L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., D'Ugo, S., Depalma, N., Spampinato, M. G., Bartolucci, P., Brachini, G., Bruzzaniti, P., Chiappini, A., Chiarella, V., Ciccarone, F., Cicerchia, P. M., Cirillo, B., De Toma, G., Di bartolomeo, A., Fiori, E., Fonsi, G. B., Franco, G., Frati, A., Giugliano, M., Iannone, I., La Torre, F., Lapolla, P., Leonardo, C., Marruzzo, G., Meneghini, S., Mingoli, A., Ribuffo, D., Salvati, M., Santoro, A., Sapienza, P., Scafa, A. K., Simonelli, L., Zambon, M., Capolupo, G. T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De Nardi, P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di Maria Grimaldi, S., Gelarda, E., Geretto, P., Giraudo, G., Giuffrida, M. C., Marano, A., Palagi, S., Pellegrino, L., Peluso, C., Testa, V., Agresta, F., Prando, D., Zese, M., Aquila, F., Gambacciani, C., Lippa, L., Pieri, F., Santonocito, O. S., Armatura, G., Bertelli, G., Frena, A., Marinello, P., Notte, F., Patauner, S., Scotton, G., Fulginiti, S. F., Gallo, G., Sammarco, G., Vescio, G., Balercia, P., Catarzi, L., Consorti, G., Di Marzo, F., Fontana, T., Daiko, H., Ishikawa, M., Ishiyama, K., Iwata, S., Kanematsu, K., Kanemitsu, Y., Kato, T., Kawai, A., Kobayashi, E., Kobayashi Kato, M., Moritani, K., Nakatani, F., Oguma, J., Tanase, Y., Uno, M., Al Abdallah, M., Ayasra, F., Ayasra, Y., Qasem, A., Abu Za'nouneh, F. J., Fahmawee, T., Hmedat, A., Ibrahim, A., Obeidat, K., Abdel Al, S., Abdel Jalil, R., Abou Chaar, M. K., Al-Masri, M., Al-Najjar, H., Alawneh, F., Alsaraireh, O., Elayyan, M., Ghanem, R., Lataifeh, I., Alkadeeki, G. Z., Al Maadany, F. S., Aldokali, N., Senossi, O., Subhi, M. T., Burgan, D., Kamoka, E., Kilani, A. I., Salamah, A., Salem, M., Shuwayyah, A., Abdulwahed, E., Alshareea, E., Aribi, N., Aribi, S., Biala, M., Ghamgh, R., Morgom, M., Aldayri, Z., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevicius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Ong, E. C., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin Sahid, N., Hayati, F., Jayasilan, J., Sriram, R. K., Subramaniam, S., Che Jusoh, A., Hussain, A. H., Mohamed Sidek, A. S., Mohd Yunus, M. F., Soh, J. Y., Wong, M. P. K., Zakaria, A. D., Zakaria, Z., Fadzli, A., Fathi, N. Q., Koh, P. S., Liew, Y. T., Roslani, A. C., Tang, C. Y., Teoh, L. Y., Wong, W. J., Yahaya, A. S., Alvarez, M. R., Arrangoiz, R., Cordera, F., De La Rosa Abaroa, M. A., Gomez-Pedraza, A., Hernandez, R., Maffuz-Aziz, A., Posada, J. A., Becerra Garcia, F. C., Alfaro-Goldaracena, A., Buerba, G. A., Castillejos-Molina, R. A., Chan, C., Dominguez-Rosado, I., Medina-Franco, H., Mercado, M. A., Oropeza-Aguilar, M., Pena Gomez Portugal, E., Posadas-Trujillo, O. E., Rodriguez-Covarrubias, F., Salgado-Nesme, N., Vilatoba, M., Arkha, Y., Bechri, H., El Ouahabi, A., Oudrhiri, M. Y., Derkaoui hassani, F., El Abbadi, N., Amrani, L., Belkhadir, Z. H., Benkabbou, A., Chakib, O., El Ahmadi, B., El Bouazizi, Y., Essangri, H., Ghannam, A., Majbar, A. M., Mohsine, R., Souadka, A., Hompes, R., Meima-Van Praag, E. M., Pronk, A. J. M., Sharabiany, S., Grotenhuis, B., Hartveld, L., Reijers, S., Van Houdt, W., Baaij, J., Bolster-Van Eenennaam, M., De Graaff, M., Sloothaak, D., Van Duijvendijk, P., Posma-Bouman, L., Derksen, T., Franken, J., Oosterling, S., De Bree, R., Konsten, J., Van Heinsbergen, M., Fidelis, L., Sholadoye, T. T., Tolani, M. A., Olaogun, J., Egbuchulem, I. K., Lawal, T. A., Ogundoyin, O., Olulana, D. I., Abdur-Rahman, L., Adeyeye, A., Aremu, I., Bello, J., Olasehinde, O., Popoola, A., Massoud, J., Massoud, R., Sorour, T. M., Jamal, A., Kerawala, A. A., Memon, A. S., Nafees Ahmed, R., Rai, L., Ayub, B., Hassan, N., Martins, R. S., Ramesh, P., Sayyed, R., Butt, U., Kashif, M., Khan, W. H., Qureshi, A., Umar, M., Waris Farooka, M., Wasim, T., Ayubi, A., Rashid, I., Waqar, S. H., Falcon, G. M., Robles, R., Jocson, R., Teh, C., Major, P., Bobinski, M., Kotarski, J., Rasoul-Pelinska, K., Azevedo, C., Machado, D., Mendes, F., De Sousa, X., Fernandes, U., Ferreira, C., Guidi, G., Leal, C., Marcal, A., Marques, R., Martins, D., Melo, A., Tenreiro, N., Vaz Pereira, R., Vieira, B., Almeida, J. I., Correia de Sa, T., Costa, M. J. M. A., Fernandes, V., Ferraz, I., Gil, C. G., Lima Da Silva, C., Lopes, L., Machado, N., Marialva, J., Nunes Coelho, M., Pedro, J., Pereira, C., Reis, R., Ribeiro, A., Santos, R., Saraiva, P., Silva, R., Tavares, F., Teixeira, M., Almeida, A. C., Amaral, M. J., Andrade, R., Athayde Nemesio, R., Breda, D., Camacho, C., Canhoto, C., Colino, M., Correia, S., De Barros, J., De Oliveira Lopez, A. L., Duque, M., Garrido, S., Guerreiro, P., Guimaraes, A., Lazaro, A., Lopes, C., Nogueira, O., Oliveira, A., Oliveira, J. M., Rodrigues, M., Ruivo, A., Santos, E., Silva, M., Simoes, J., Valente Da Costa, A., Almeida, A., Cavaleiro, S., Devezas, V., Faria, C. S., Jacome, F., Magalhaes Maia, M., Nogueiro, J., Pereira, A., Pereira-Neves, A., Pina-Vaz, T., Santos-Sousa, H., Silveira, H., Vaz, S., Vieira, P., Gomes Da Costa, A., Lobo Antunes, I., Pinto, J., Tojal, A., Cardoso, N., Cardoso, P., Domingues, J. C., Henriques, P., Manso, M. I., Martins Dos Santos, G., Morais, H., Pereira, R., Revez, T., Ribeiro, R., Ribeiro, V. I., Sousa, S., Teixeira, J., Amorim, E., Baptista, V. H., Cunha, M. F., Dias, B., Fazenda, A., Melo Neves, J. P., Policarpo, F., Sampaio Da Novoa Gomes Miguel, I. I., Veiga, D., Andrade, A. K., Bandovas, J. P., Borges, N., Branquinho, A., Chumbinho, B., Correia, J., Fidalgo, H., Figueiredo De Barros, I., Frade, S., Gomes, J., Maciel, J., Pina, S., Rodrigues, A., Silva, N., Silveira Nunes, I., Sousa, R., Ascensao, J., Azevedo, P., Costeira, B., Cunha, C., Garrido, R., Gomes, H., Lourenco, I., Mendinhos, G., Miranda, P., Nobre Pinto, A., Peralta Ferreira, M., Ribeiro, J., Rio Rodrigues, L., Sousa Fernandes, M., Azevedo, J., Galvao, D., Soares, A. C., Vieira, A., Patricio, B., Santos, P. M. D. D., Vieira Paiva Lopes, A. C., Cunha, R., Faustino, A., Freitas, A., Martins, A. B., Mendes, J. R., Parreira, R., Rosa, J., Teves, M., Abreu Da Silva, A., Claro, M., Costa Santos, D., Deus, A. C., Grilo, J. V., Borges, F., Corte Real, J., Henriques, S., Lima, M. J., Matos Costa, P., Brito da Silva, F., Caiado, A., Fonseca, F., Angelo, M., Baiao, J. M., Martins Jordao, D., Vieira Caroco, T., Messias, J., Millan, A., Salgado, I., Baia, C., Canotilho, R., Correia, A. M., Ferreira Pinto, A. P., Peyroteo, M., Videira, J. F., Escobar, P., Maldonado Santiago, M., Kassir, R., Sauvat, F., Bezede, C., Chitul, A., Ciofic, E., Cristian, D., Grama, F., Pirtea, L., Secosan, C., Bonci, E., Gata, V., Titu, S., Ginghina, O., Iordache, N., Iosifescu, R. V., Garmanova, T., Kazachenko, E., Markaryan, D., Rodimov, S., Tsarkov, P., Tulina, I., Litvina, Y., Provozina, A., Agapov, M., Galliamov, E., Kakotkin, V., Kubyshkin, V., Alshahrani, M., Alsharif, F., Eskander, M., Al Raddadi, R., Majrashi, S., Mashat, A., Akeel, N., Alharthi, M., Aljiffry, M., Basendowah, M., Farsi, A., Ghunaim, M., Khoja, A., Maghrabi, A., Malibary, N., Nassif, M., Nawawi, A., Saleem, A., Samkari, A., Trabulsi, N., Al Awwad, S., Alghamdi, M., Alnumani, T., Nasser, M., Said bayazeed, A., Alhefdhi, A., Almalik, O., Alomair, A., Alotaibi, N., Alresaini, F., Alsalamah, R., Alsobhi, S., Mahasin, Z., Othman, E., Velagapudi, S., Ghedan, S., Alharthi, R., Awad, S., Sharara, M., Abdelrahman, S., Althobaiti, W., Al Habes, H., Alamri, A., Alkarak, S., Alqannas, M., Alyami, M., Alzamanan, M., Cortes Guiral, D., Elawad, A., Alaamer, O., Alriyees, L., Alselaim, N., Abdulkareem, A., Ajlan, A., Akkour, K., Al-Habib, A., Al-Khayal, K., Alatar, A., Alburakan, A., Alhalal, H., Alhassan, B., Alhassan, N., Alobeed, O., Alsaif, A., Alsaif, F., Alshammari, S., Alshaygy, I., Barry, M., Bin Nasser, A., Bin Traiki, T., Bokhari, A., Elwatidy, S., Helmi, H., Madkhali, A., Nouh, T., Rabah, P. D., Zubaidi, A., Paunovic, I., Slijepcevic, N., Aleksic, L., Antic, A., Barisic, G., Ceranic, M., Galun, D., Grubac, Z., Jelenkovic, J., Kecmanovic, D., Kmezic, S., Knezevic, D., Krivokapic, Z., Latincic, S., Markovic, V., Matic, S., Miladinov, M., Pavlov, M., Pejovic, I., Radenkovic, D., Tadic, B., Vasljevic, J., Velickovic, D., Zivanovic, M., Perovic, M., Srbinovic, L., Andrijasevic, S., Bozanovic, T., Cerovic Popovic, R., Dokic, M., Janjic, T., Jeremic, K., Kadija, S., Ladjevic Likic, I., Mirkovic, L., Pantovic, S., Pilic, I., Radojevic, M., Stefanovic, A., Vidakovic, S., Vilendecic, Z., Antic, S., Dunderovic, D., Jelovac, D., Jezdic, Z., Konstantinovic, V., Kotlar, B., Kuzmanovic, C., Lazic, M., Petrovic, M., Popovic, F., Pucar, A., Romic, M., Sumrak, S., Vujanac, V., Bascarevic, V., Bogdanovic, I., Grujicic, D., Ilic, R., Milicevic, M., Milisavljevic, F., Miljkovic, A., Paunovic, A., Scepanovic, V., Stanimirovic, A., Todorovic, M., Jotic, A., Milovanovic, J., Trivic, A., Bumbasirevic, U., Dzamic, Z., Kajmakovic, B., Prijovic, N., Zivkovic, M., Buta, M., Cvetkovic, A., Djurisic, I., Gacic, S., Goran, M., Inic, Z., Jeftic, N., Jevric, M., Jokic, V., Markovic, I., Milanovic, M., Nikolic, S., Pejnovic, L., Savkovic, N., Spurnic, I., Stevic, D., Stojiljkovic, D., Vucic, N., Zegarac, M., Karamarkovic, A., Kenic, M., Kovacevic, B., Krdzic, I., Milutinovic, V., Lieske, B., Galis, B., Simko, K., Almgla, N., Bernon, M., Boutall, A., Cairncross, L., Herman, A., Hilton, T., Jonas, E., Kloppers, C., Malherbe, F., Mugla, W., Nel, D., Rayamajhi, S., Van Wyngaard, T., Vogel, J., Castano-Leon, A. M., Delgado Fernandez, J., Eiriz Fernandez, C., Espino Segura-Illa, M., Esteban Sinovas, O., Garcia Perez, D., Gomez, P., Jimenez-Roldan, L., Lagares, A., Moreno-Gomez, L., Paredes, I., Perez Nunez, A., Sanchez Aniceto, G., Santas, M., Fernandez Rodriguez, P., Paniagua Garcia Senorans, M., Sanchez-Santos, R., Vigorita, V., Acrich, E., Baena Sanfeliu, E., Barrios, O., Golda, T., Santanach, C., Serrano-Navidad, M., Sorribas Grifell, M., Vives, R. V., Escola, D., Jimenez, A., Cayetano Paniagua, L., Gomez Fernandez, L., Artigues, E., Bernal-Sprekelsen, J. C., Catala Bauset, J. C., Collera, P., Diaz Del Gobbo, R., Farre Font, R., Flores Clotet, R., Gomez Diaz, C. J., Guardia, N., Guariglia, C. A., Osorio, A., Sanchez Jimenez, R., Sanchon, L., Soto Montesinos, C., Albi Martin, B., Garcia Villayzan, J. E., Alonso-Lamberti, L., Assaf, M., Baeza Pintado, N., Carabias, A., Garcia-Quijada, J., Huertas Fernandez, M. A., Jimenez Miramon, J., Jimenez, V., Jover, J. M., Landeo Aguero, S. A., Leon, R., Martin Salamanca, M. B., Perez Simon, V., Ponce, S., Rodriguez, J. L., Salazar, A., Valle Rubio, A., Aguado, H., Aldecoa Ansorregui, I., Bravo Infante, R., De Lacy, F. B., Di Somma, A., Diaz-Feijoo, B., Ensenat Nora, J., Fabregas, N., Ferres, A., Gil Ibanez, B., Gonzalez Sanchez, J. J., Gracia, I., Hoyos Castro, J. A., Lacy, A. M., Langdon, C., Momblan, D., Morales, X., Oleaga, L., Otero, A., Pedrosa, L., Poblete Carrizo, J., Reyes Figueroa, L. A., Roldan Ramos, P., Rumia-Arboix, J., Tercero-Uribe, A. I., Topczewski, T. E., Torales, J., Torne, A., Torne, R., Turrado-Rodriguez, V., Valero, R., Valverde, S., Anula, R., Cano-Valderrama, O., Del Campo Martin, M., Diez-Valladares, L., Dominguez, I., Dziakova, J., Garcia Alonso, M., Garcia Romero, E., Gomez Latorre, L., Muguerza, J. M., Pizarro, M. J., Saez Carlin, P., Sanchez Del Pueblo, C., Sanchez-Pernaute, A., Sanz Ortega, G., Sanz-Lopez, R., Torres, A., Garces-Albir, M., Lopez, F., Martin-Arevalo, J., Moro-Valdezate, D., Pla-Marti, V., Beltran De Heredia, J., De Andres Asenjo, B., Gomez Sanz, T., Jezieniecki, C., Nunez Del Barrio, H., Ortiz De Solorzano Aurusa, F. J., Romero De Diego, A., Ruiz Soriano, M., Trujillo Diaz, J., Vazquez Fernandez, A., Lora-Cumplido, P., Sosa, M. V., Gonzalez-Gonzalez, E., Minaya Bravo, A. M., Alonso de la Fuente, N., Cazador Labat, M., Cecchini, L., Espinosa, C. A., Jimenez Toscano, M., Lopez Campillo, A., Mancebo, G., Martorell, P., Munarriz, M., Grau-Talens, E. J., Martin-Perez, B., Benavides Buleje, J. A., Carrasco Prats, M., Fernandez, P. V., Fernandez-Lopez, A., Garcia Escudero, D., Garcia Porcel, V. J., Garcia Soria, V., Gimenez Frances, C., Gonzalez Valverde, F. M., Gurrea, E., Lopez-Morales, P., Marco Garrido, A., Martinez Alonso, J. A., Medina, E., Munoz Camarena, J. M., Parra Banos, P. A., Pena Ros, E., Ramirez Faraco, M., Ruiz-Marin, M., Sanchez Rodriguez, C., Valero Soriano, M., Estaire Gomez, M., Fernandez Camunas, A., Garcia Santos, E. P., Jimenez Higuera, E., Martinez-Pinedo, C., Munoz-Atienza, V., Padilla-Valverde, D., Picon Rodriguez, R., Redondo Calvo, F. J., Sanchez-Garcia, S., Sanchez-Pelaez, D., Colombari, R. C., Del valle, E., Fernandez, M., Lozano Lominchar, P., Rey Valcarcel, C., Steiner, M. A., Tudela, M., Zorrilla Ortuzar, J., Alcaide Matas, F., Garcia Perez, J. M., Troncoso Pereira, P., Mora-Guzman, I., Abellan, M., Achalandabaso Boira, M., Jorba, R., Memba Ikuga, R., Olona, C., Sales Mallafre, R., Cavalle Busquets, P., Gavalda Pellice, M. G. P., Salinas Pena, J., Aragon Achig, E. J., Barbier, L., Caja Vivancos, P., Gainza, A., Garcia Gutierrez, J. J., Mallabiabarrena Ormaechea, G., Marin, H., Martin Playa, P., Melchor Corcostegui, I., Prieto Calvo, M., Rodriguez Fraga, A., Villalabeitia Ateca, I., De Andres Olabarria, U., Duran Ballesteros, M., Fernandez Pablos, F. J., Ibanez-Aguirre, F. J., Sanz Larrainzar, A., Ugarte-Sierra, B., De La Hoz Rodriguez, A., Di Martino, M., Garcia Septiem, J., Martin-Perez, E., Munoz De Nova, J. L., Calvo Espino, P., Guillamot Ruano, P., Colao Garcia, L., Diaz Perez, D., Esteban Agusti, E., Galindo Jara, P., Gutierrez Samaniego, M., Hernandez Bartolome, M. A., Serrano Gonzalez, J., Alonso Poza, A., Dieguez, B., Garcia-Conde, M., Hernandez-Garcia, M., Losada, M., Chiesa-Estomba, C. M., Gonzalez Garcia, J. A., Larruscain, E., Sistiaga-Suarez, J. A., Alvarez, E., Chavarrias, N., Frias, L., Garcia Pineda, V., Gegundez Simon, A., Gortazar, S., Gracia, M., Guevara, J., Hernandez Gutierrez, A., Loayza, A., Maria Dolores, D. T., Marti, C., Melendez, M., Moreno-Palacios, E., Perez, Y., Prieto Nieto, M. I., Ramos-Martin, P., Rubio-Perez, I., Saavedra, J., Sanchez-Mendez, J. I., Siegrist Ridruejo, J., Urbieta, A., Zapardiel, I., Cantalejo diaz, M., De Miguel Ardevines, M. D. C., Duque-Mallen, V., Gascon Ferrer, I., Gonzalez-Nicolas Trebol, M. T., Gracia-Roche, C., Herrero Lopez, M., Jariod Ferrer, U. M., Lanzon, A., Martinez German, A., Matute, M., Redondo, C., Sanchez Fuentes, N., Sanchez-Rubio, M., Santero-Ramirez, M. S., Saudi, S., Simon Sanz, M. V., Uson-Bouthelier, T., Blazquez Martin, A., Diez Alonso, M., Garcia Rico, E., Garcia-Loarte Gomez, E., Garcia-Moreno Nisa, F., Gutierrez Calvo, A., Hernandez, P., Lasa, I., Mendoza-Moreno, F., Morales Palacios, N., Ovejero Merino, E., Vera Mansilla, C., Acebes Garcia, F., Bailon, M., Bueno Canones, A. D., Choolani Bhojwani, E., Marcos-Santos, P., Miguel, T., Pacheco Sanchez, D., Perez-Saborido, B., Sanchez Gonzalez, J., Tejero-Pintor, F. J., Alconchel, F., Conesa, A., Gil Martinez, J., Gutierrez Fernandez, A. I., Lopez Abad, A., Nicolas-Lopez, T., Ramirez Romero, P., Roca Calvo, M. J., Rodrigues, K., Ruiz Manzanera, J. J., Soriano, A. I., Cano, A., Capitan-Morales, L., Cintas Catena, J., Gomez-Rosado, J., Oliva Mompean, F., Perez Sanchez, M. A., Rio Lafuente, F. D., Torres Arcos, C., Valdes-Hernandez, J., Cholewa, H., Domingo, S., Frasson, M., Lago, V., Marina Martin, T., Martinez Chicote, C., Sancho-Muriel, J., Landaluce-Olavarria, A., Lecumberri, D., Abad Gurumeta, A., Abad-Motos, A., Martinez-Hurtado, E., Ripolles-Melchor, J., Ruiz Escobar, A., Cuadrado-Garcia, A., Garcia-Sancho Tellez, L., Heras Aznar, J., Mate, P., Ortega Vazquez, I., Picardo, A. L., Rojo Lopez, J. A., Sanchez Cabezudo Noguera, F., Serralta De Colsa, D., Anchuelo Latorre, J., Cagigas Fernandez, C., Caina Ruiz, R., Gomez Ruiz, M., Hernanz, F., Jimeno Fraile, J., Martinez-Perez, P., Poch, C., Santarrufina Martinez, S., Valbuena Jabares, V., Moliner-Sanchez, C., Pingarron-Martin, L., Rey-Biel, J., Ruiz Martin, I., Blas Laina, J. L., Cros, B., Escartin, J., Garcia Egea, J., Nogues, A., Talal El-Abur, I., Yanez, C., Cagigal Ortega, E. P., Cervera, I., Diaz Pena, P., Elena, G. D. C. R., Enjuto, D., Fernandez Bernabe, P., Garces Garcia, R., Gonzalez, J., Hernandez, I., Herrera-Merino, N., Marqueta De Salas, M., Martinez Pascual, P., Perez Gonzalez, M., Ramos Bonilla, A., Rodriguez Gomez, L., Bescos, C., Blanco-Colino, R., Brana, I., Caimari, B., De Pablo Garcia-Cuenca, A., Duran-Valles, F., Espin-Basany, E., Giralt Lopez De Sagredo, J., Pamias, J., Pellino, G., Prat, N., Pujol Pina, R., Saez Barba, M., Arulanantham, A., Bandara, G. B. K., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S., Srishankar, S., Ali Karar, A. A., Elbe, P., Lindqvist, E. K., Taflin, H., Alga, A., Heinius, G., Nordberg, M., Pieniowski, E., Gkekas, I., Lofgren, N., Rutegard, M., Sund, M., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Klenke, F., Kollar, A., Kurze, C., Adamina, M., Bachler, T., Crugnale, A. S., Giardini, M., Guglielmetti, L., Peros, G., Solimene, F., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Dulgeroglu, O., Ozben, V., Ozmen, B. B., Uras, C., Arikan, A. E., Bilgin, I. A., Bozkirli, B., Ceyhan, G. O., Kara, H., Karahasanoglu, T., Celik, H., Meydanli, M. M., Akilli, H., Ayhan, A., Kuscu, E., Onan, M. A., Akgor, U., Dincer, H. A., Erol, T., Gultekin, M., Orhan, N., Ozgul, N., Salman, M. C., Soyak, B., Alhamed, A., Ergun, S., Ozcelik, M. F., Sanli, A. N., Uludag, S. S., Velidedeoglu, M., Zengin, A. K., Bozkurt, M. A., Kara, Y., Kocatas, A., Cimenoglu, B., Demirhan, R., Saracoglu, K., Azamat, I. F., Balik, E., Bugra, D., Giray, B., Kulle, C. B., Taskiran, C., Vatansever, D., Gozal, K., Guler, S. A., Koken, H., Tatar, O. C., Utkan, N. Z., Yildirim, A., Yuksel, E., Akin, E., Altintoprak, F., Bayhan, Z., Cakmak, G., Capoglu, R., Celebi, F., Demir, H., Dikicier, E., Firat, N., Gonullu, E., Kamburoglu, M. B., Kocer, B., Kucuk, I. F., Mantoglu, B., Colak, E., Kucuk, G. O., Uyanik, M. S., Goksoy, B., Bozkurt, E., Citgez, B., Mihmanli, M., Tanal, M., Yetkin, G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli Atici, S., Emiroglu, M., Kaya, T., Kebabci, E., Kilinc, G., Kirmizi, Y., Ogucu, H., Salimoglu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yesilyurt, D., Karaman, E., Kolusari, A., Yildiz, A., Benson, O., Lule, H., Agilinko, J., Ahmeidat, A., Barabasz, M., Bekheit, M., Cheung, L. K., Colloc, T., Cymes, W., Elhusseini, M., Gradinariu, G., Hannah, A., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Abu-Nayla, I., Agrawal, A., Al-Mohammad, A., Ali, S., Ashcroft, J., Azizi, A., Baker, O., Balakrishnan, A., Byrne, M., Colquhoun, A., Cotter, A., Coughlin, P., Davies, R. J., Durrani, A., Elshaer, M., Fordington, S., Forouhi, P., Georgiades, F., Grimes, H., Habeeb, A., Hudson, V., Hutchinson, P., Irune, E., Jah, A., Khan, D. Z., Kyriacou, H., Lamb, B., Liau, S., Luke, L., Mahmoud, R., Mannion, R., Masterson, L., Mitrofan, C. G., Mohan, M., Morris, A., Murphy, S., O'Neill, R., Price, S., Pushpa-Rajah, J., Raby-Smith, W., Ramzi, J., Rooney, S., Santarius, T., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Walker, C., Waseem, S., Yordanov, S., Jones, T., Kattakayam, A., Loh, C., Lunevicius, R., Pringle, S., Schache, A., Sheel, A., Rossborough, C., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Tutoveanu, G., Ahad, S., De La Cruz Monroy, M. F. I., Mosley, F., Oktseloglou, V., Alanbuki, A., Patel, M., Shabana, A., Perera, E., Raveendran, D., Ravi-Shankar, K., Thiruchelvam, J., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Rolland, P., Aggarwal, A., Brown, S., Jelley, C., Neal, N., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy Mahapatra, S., Serevina, O. L., Smith, C., Vimalachandran, D., Bordenave, M., Houston, R., Putnam, G., Robson, A., Tustin, H., Emslie, K., Labib, P. L., Marchbank, A., Miller, D., Minto, G., Natale, J., Nwinee, H., Panahi, P., Rogers, L., Abubakar, A., Akhter Rahman, M. M., Ko, K. Y. K., O'Brien, H., Sasapu, K., Woodun, H., Inglis, R., Ng, H. J., De Gea Rico, A., Ghazali, N., Lambert, J., Markose, G., Math, S., Sarantitis, I., Shrestha, D., Sultana, A., Taggarsi, M., Timbrell, S., Vaz, O. P., Vitone, L., Day, A., Dent, H., Fahim, M., Waheed, S., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Hardie, J., Kazzaz, S., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Amonkar, S., Blackwell, L., Blake, D., Carter, J., Emerson, H., Fisher, A., Katory, M., Korompelis, P., Mccormick, W., Mustafa, A., Pearce, L., Ratnavelu, N., Reehal, R., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram Venkatesan, G., Ang, K., Caruana, E. J., Chowdhry, M. F., Mohammad, A., Nakas, A., Rathinam, S., Boal, M., Brown, O., Dwerryhouse, S., Higgs, S., Vallance, A., Boyd, E., Irvine, V., Kirk, A., Bakolas, G., Boulton, A., Chandock, A., Khan, T., Kumar, M., Agoston, P., Bille, A., Challacombe, B., Fraser, S., Harrison-Phipps, K., King, J., Mehra, G., Mills, L., Najdy, M., Nath, R., Okiror, L., Pilling, J., Rizzo, V., Routledge, T., Sayasneh, A., Stroman, L., Wali, A., Fehervari, M., Fotopoulou, C., Habib, N., Hamrang-Yousefi, S., Jawad, Z., Jiao, L., Pai, M., Ploski, J., Rajagopal, P., Saso, S., Sodergren, M., Spalding, D., Laws, S., Hardie, C., Mcnaught, C., Alam, R., Budacan, A., Cahill, J., Kalkat, M., Karandikar, S., Kenyon, L., Naumann, D., Patel, A., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem Ibrahim, A., Bichoo, R., Cao, H., Chai, A. K. W., Choudhury, J., Evans, C., Fitzjohn, H., Ikram, H., Langstroth, M., Loubani, M., Mcmillan, A., Nazir, S., Qadri, S. S. A., Robinson, A., Ross, E., Sehgal, T., Wilkins, A., Dixon, J., Dunning, J., Freystaetter, K., Jha, M., Lester, S., Madhavan, A., Thulasiraman, S. V., Viswanath, Y., Curl-Roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Belcher, E., Bond-Smith, G., Chidambaram, S., Di Chiara, F., Fasanmade, K., Fraser, L., Fu, H., Ganau, M., Gore, S., Graystone, J., Jeyaretna, D., Khatkar, H., Lami, M., Maher, M., Mastoridis, S., Mihai, R., Piper, R., Prabhu, S., Risk, O. B. F., Selbong, U., Shah, K., Smillie, R., Soleymani majd, H., Sravanam, S., Stavroulias, D., Tebala, G. D., Vatish, M., Verberne, C., Wallwork, K., Winter, S., Bhatti, M. I., Boyd-Carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Bourke, G., Bradshaw, L., Brunelli, A., Burke, J., Coe, P., Costigan, F., Elkadi, H., Johnstone, J., Kanatas, A., Kantola, V., Kaufmann, A., Laios, A., Lam, S., Macinnes, E., Munot, S., Nahm, C., Otify, M., Pompili, C., Smith, I., Theophilou, G., Toogood, G., Wade, R., Ward, D., West, C., Annamalai, S., Ashmore, C., Boddy, A., Hossain, T., Kourdouli, A., Gvaramadze, A., Jibril, A., Prusty, L., Thekkinkattil, D., Harky, A., Shackcloth, M., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Shaw, S., Talwar, R., Abdalla, M., Edmondson, R., Ismail, O., Jones, D., Newton, K., Stylianides, N., Aderombi, A., Andaleeb, U., Bajomo, O., Beatson, K., Garrett, W., Mehmood, M., Ng, V., Al-Habsi, R., Divya, G. S., Keeler, B., Al-Sarireh, B., Egan, R., Harries, R., Henry, A., Kittur, M., Li, Z., Parkins, K., Soliman, F., Spencer, N., Thompson, D., Burgess, C., Gemmell, C., Grieco, C., Hollyman, M., Hunt, L., Morrison, J., Ojha, S., Ryan, N., Abbadessa, F., Barnard, S., Dawe, N., Hammond, J., Mahmoud Ali, F., Mcpherson, I., Mellor, C., Moir, J., Pandanaboyana, S., Powell, J., Rai, B., Roy, C., Sachdeva, A., Saleh, C., Tingle, S., Williams, T., Manickavasagam, J., Mcdonald, C., Mcgrath, N., Mcsorley, N., Ragupathy, K., Ramsay, L., Solth, A., Kakisi, O., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Ameerally, P., Mclarty, N., Mills, S., Shenfine, A., Sahnan, K., Abu, J., Addae-Boateng, E., Bratt, D., Brock, L., Burnside, N., Cadwell-Sneath, S., Gajjar, K., Gan, C., Grundy, C., Hallam, K., Hassell, K., Hawari, M., Joshi, A., Khout, H., Konstantinidi, K., Lee, R. X. N., Nunns, D., Schiemer, R., Walton, T., Weaver, H., Whisker, L., Williamson, K., Mcveigh, J., Myatt, R., Williams, M. A., Kaur, R., Leung, E., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Edmond, M., King, E., Almond, M., Breik, O., Cato, L. D., Idle, M., Kamal, M., Kisiel, A., Kulkarni, R., Mak, J. K. C., Martin, T., Nankivell, P., Parente, A., Parmar, S., Pathanki, A. M., Phelan, L., Praveen, P., Saeed, S., Sharma, N., Singh, J., Tirotta, F., Vijayan, D., Geddes, A., Mccaul, J., Mcmahon, J., Khan, A. H., Khan, F., Mansuri, A., Mukherjee, S., Sarigul, M., Singh, S., Tan, K. L., Woodham, A., Adiamah, A., Brewer, H., Chowdhury, A., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis-Lloyd, C., Oyende, O., Reilly, J., Worku, D., Cool, P., Cribb, G., Shepherd, K., Bisset, C., Moug, S., Elson, N., Faulkner, G., Saleh, P., Underwood, C., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Goyal, A., Grimley, E., Hamad, A., Kumar, A., Malcolm, F. L., Theophilidou, E., Bowden, J., Campain, N., Daniels, I., Fowler, G., John, J., Massey, L., Mcdermott, F., Mcgrath, J., Mclennan, A., Ng, M., Pascoe, J., Rajaretnam, N., Bulathsinhala, S., Davidson, B., Fusai, G., Hidalgo Salinas, C., Machairas, N., Pissanou, T., Pollok, J. M., Raptis, D. A., Soggiu, F., Tzerbinis, H., Xyda, S. E., Beamish, A., Davies, E., Foulkes, R., Magowan, D., Nassa, H., Ooi, R., Price, C., Solari, F., Tang, A., Williams, G., Al-Tamimi, Y., Bacon, A., Beasley, N., Chew, D., Crank, M., Ilenkovan, N., Macdonald, M., Narice, B., Rominiyi, O., Thompson, A., Varley, I., Drake, T., Harrison, E., Linder, G., Mayes, J., Mcgregor, R., Skipworth, R., Zamvar, V., Hawkin, P., Raymond, T., Ryska, O., Baron, R., Dunne, D., Gahunia, S., Halloran, C., Howes, N., Mckinney, R., Mcnicol, F., Russ, J., Szatmary, P., Tan, J. R., Thomas, A., Whelan, P., Anzak, A., Banerjee, A., Fuwa, O., Hughes, F., Jayasinghe, J. D., Knowles, C., Kocher, H., Leal Silva, I., Ledesma, F. S., Minicozzi, A., Navaratne, L., Rahman, R., Ramamoorthy, R., Sohrabi, C., Thaha, M., Thakur, B., Yip, V., Baumber, R., Parry, J., Evans, S., Jeys, L., Morris, G., Parry, M., Ahmadi, N., Aresu, G., Barrett-Brown, Z. M., Coonar, A. S., Durio Yates, H., Gearon, D., Hogan, J., King, M., Peryt, A., Pradeep, I. S., Adishesh, M., Atherton, R., Baxter, K., Brocklehurst, M., Chaudhury, M., Krishnamohan, N., Mcaleer, J., Owens, G., Parkin, E., Patkar, P., Phang, I., Aladeojebi, A., Ali, M., Barmayehvar, B., Gaunt, A., Gowda, M., Halliday, E., Kitchen, M., Mansour, F., Thomas, M., Zakai, D., Abbassi-Ghadi, N., Assalaarachchi, H., Currie, A., Flavin, M., Frampton, A., Hague, M., Hammer, C., Hopper, J., Horsnell, J., Humphries, S., Kamocka, A., Madhuri, T. K., Preston, S., Singh, P., Stebbing, J., Tailor, A., Walker, D., Aljanadi, F., Jones, M., Mhandu, P., O'Donnell, C., Turkington, R., Al-Ishaq, Z., Bhasin, S., Bodla, A. S., Burahee, A., Crichton, A., Fossett, R., Pigadas, N., Pickford, S., Rahman, E., Snee, D., Yassin, N., Fountain, D., Hasan, M. T., Karabatsou, K., Laurente, R., Pathmanaban, O., Al-Mukhtar, A., Giblin, A., Kelty, C., Lee, M., Lye, G., Newman, T., Sharkey, A., Steele, C., Sureshkumar Shah, N., Whitehall, E., Athwal, R., Baker, A., Jones, L., Konstantinou, C., Ramcharan, S., Vatish, J., Wilkin, R., Ethunandan, M., Sekhon, G. K., Shields, H., Singh, R., Wensley, F., Lawday, S., Lyons, A., Abbott, T., Anwar, S., Ghufoor, K., Chung, E., Hagger, R., Hainsworth, A., Karim, A., Owen, H., Ramwell, A., Williams, K., Baker, C., Davies, A., Gossage, J., Kelly, M., Knight, W., Hall, J., Harris, G., James, G., Kang, C., Lin, D. J., Rajgor, A. D., Royle, T., Scurrah, R., Steel, B., Watson, L. J., Choi, D., Hutchison, R., Jain, A., Luoma, V., Marcus, H., May, R., Menon, A., Pramodana, B., Webber, L., Aneke, I. A., Asaad, P., Brown, B., Collis, J., Duff, S., Moura, F., Wadham, B., Warburton, H., Elmoslemany, T., Jenkinson, M., Millward, C., Zakaria, R., Mccluney, S., Parmar, C., Shah, S., Allison, J., Babar, M. S., Collard, B., Goodrum, S., Lau, K., Scott, R., Thomas, E., Whitmore, H., Balasubramaniam, D., Jayasankar, B., Kapoor, S., Ramachandran, A., Elhamshary, A., Imam, S. M. B., Kapriniotis, K., Kasivisvanathan, V., Lindsay, J., Rakhshani-Moghadam, S., Beech, N., Chand, M., Green, L., Kalavrezos, N., Kiconco, H., Mcewen, R., Schilling, C., Sinha, D., Pereca, J., Chopra, S., Egbeare, D., Thomas, R., Combellack, T., Jones, S. E. F., Kornaszewska, M., Mohammed, M., Sharma, A., Tahhan, G., Valtzoglou, V., Williams, J., Eskander, P., Gash, K., Gourbault, L., Hanna, M., Maccabe, T., Newton, C., Olivier, J., Rozwadowski, S., Teh, E., West, D., Al-Omishy, H., Baig, M., Bates, H., Di Taranto, G., Dickson, K., Dunne, N., Gill, C., Howe, D., Jeevan, D., Khajuria, A., Martin-Ucar, A., Mcevoy, K., Naredla, P., Robertson, S., Sait, M., Sarma, D. R., Shanbhag, S., Shortland, T., Simmonds, S., Skillman, J., Tewari, N., Walton, G., Akhtar, M. A., Brunt, A., Mcintyre, J., Milne, K., Rashid, M. 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Royle, T, Scurrah, R, Steel, B, J Watson, L, Choi, D, Hutchison, R, Jain, A, Luoma, V, Marcus, H, May, R, Menon, A, Pramodana, B, Webber, L, A Aneke, I, Asaad, P, Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Wadham, B, Warburton, H, Elmoslemany, T, Jenkinson, M, Millward, C, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, S Babar, M, Collard, B, Goodrum, S, Lau, K, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Elhamshary, A, Imam, Smb, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, Mcewen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Combellack, T, Jones, Sef, Kornaszewska, M, Mohammed, M, Sharma, A, Tahhan, G, Valtzoglou, V, Williams, J, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, T, Newton, C, Olivier, J, Rozwadowski, S, Teh, E, West, D, Al-Omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar AMcEvoy, K, Naredla, P, Robertson, S, Sait, M, R Sarma, D, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, A Akhtar, M, Brunt, A, Mcintyre, J, Milne, K, M Rashid, M, Sgro, A, E Stewart, K, Turnbull, A, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Patki, P, Tanabalan, C, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, Macdonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Jones, R, S Kolli, V, K Lala, A, Leeson, S, Peevor, R, Seymour, Z, Chen, L, Henderson, E, Loehrer, A, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, Mcelhinney, K, Olson, K, C Osterberg, E, Riley, C, Srikanth, P, Thornhill, M, Blazer, D, Dilalla, G, S Hwang, E, Lee, W, Lidsky, M, Plichta, J, Rosenberger, L, Scheri, R, Turnage, K, Visgauss, J, Zani, S, Farma, J, Clark, J, Kwon, D, Etchill, E, E Gabre-Kidan AJenny, H, Kent, A, Ladd, M, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Brown, L, Ganly, I, Mullinax, J, Gusani, N, Hazelton, J, Maines, J, S Oh, J, Ssentongo, A, Ssentongo, P, Azam, M, Choudhry, A, Marx, W, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, K Abel, M, Andaya, V, Bigay, K, A Boeck, M, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, Bc, Heaton, C, Hirose, K, M Jablons, D, Kirkwood, K, Z Kornblith, L, R Kratz, J, Lee, R, N Miller, P, Nakakura, E, Nunez-Garcia, B, O'Donnell, R, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, M, Wai, K, Wustrack, R, J Xu, M, Beswick, D, Goddard, J, Manor, J, Song, J, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, L Roland, C, N Zafar, S, Abdallah, M, Abouassi, A, Almasri, M, Kulkarni, G, Marwan, H, Mehdi, M, Aoun, S, S Ban, V, H Batjer, H, Caruso, J, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, P, Hawkins, A, Maiga, A, Laufer, J, Scasso, S, Surgery, Graduate School, Glasbey, J, Nepogodiev, D, Simoes, J, Omar, O, Li, E, Abou Chaar, M, Chaudhry, D, Videria, J, Gujjuri, R, Kaafarani, H, Minaya-Bravo, A, Mckay, S, Roberts, K, Miguel-Mendez, C, Smart, N, Stewart, G, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), COVIDSurg Collaborative, Kolias, Angelos [0000-0003-3992-0587], Stewart, Grant [0000-0003-3188-9140], Apollo - University of Cambridge Repository, Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Pgdme, Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I, Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar Mrcog S, Vidya R, Bhangu AA, COVIDSurg Collaborative, Palmerini Emanuela, Frisoni Tommaso, Donati Davide, A Belvedere, P Bernante, P Bertoglio, S Boussedra, E Brunocilla, R Cipriani, G Cisternino, E De Crescenzo, P De Iaco, G Dondi, F Frio, E Jovine, F Mineo Bianchi, J Neri, D Parlanti, A M Perrone, A P Pezzuto, M Pignatti, V Pinto, G Poggioli, M Ravaioli, M Rottoli, R Schiavina, M Serenari, M Serra, P Solli, M Taffurelli, M Tanzanu, M Tesei, T Violante, S Zanotti, V Tonini, M Cervellera, A Gori, L Sartarelli, Glasbey, James C, Simoes, Joana F F, Venn, Mary L, Pgdme, null, Abou Chaar, Mohammad K, Edwards, Jonathan G, Evans, Jonathan P, Videria, Jose Flavio, Ford, Samuel J, Griffiths, Ewen A, Gujjuri, Rohan R, Kolias, Angelos G, Kaafarani, Haytham M A, McKay, Siobhan C, Mohan, Helen M, Roberts, Keith J, Smart, Neil J, Stewart, Grant D, Sundar Mrcog, Sudha, and Bhangu, Aneel A, Toia, F
Subjects: Male, Cancer Research, Outcome Assessment, International Cooperation, Settore MED/18 - CHIRURGIA GENERALE, Settore MED/19 - Chirurgia Plastica, 030230 surgery, Aged, Aged, 80 and over, COVID-19, Cohort Studies, Critical Care, Elective Surgical Procedures, Epidemics, Female, Humans, Logistic Models, Middle Aged, Neoplasms, Outcome Assessment, Health Care, Postoperative Complications, SARS-CoV-2, 0302 clinical medicine, Operating theater, cohort studies, Health care, middle aged, 80 and over, Medicine, Lung, Cancer, COVID-19/epidemiology, OUTCOMES, Manchester Cancer Research Centre, Pulmonary Complication, ORIGINAL REPORTS, aged, Oncology, 030220 oncology & carcinogenesis, Pneumonia & Influenza, Patient Safety, Elective Surgical Procedure, Life Sciences & Biomedicine, 6.4 Surgery, Cohort study, Human, medicine.medical_specialty, elective surgical procedures/methods, Logistic Model, Health Care, Clinical Sciences, Oncology and Carcinogenesis, Epidemic, [SDV.CAN]Life Sciences [q-bio]/Cancer, cancer surgery, SARS-CoV-2 pandemic, epidemics, COVIDSurg Collaborative, NO, outcome assessment, health care/methods, 03 medical and health sciences, male, Settore MED/28 - Malattie Odontostomatologiche, Clinical Research, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Elective surgery, Elective Cancer Surgery in SARS-CoV-2, Elective Cancer Surgery in COVID-19, covid 19, sars-cov-2, Science & Technology, business.industry, Prevention, ResearchInstitutes_Networks_Beacons/mcrc, Evaluation of treatments and therapeutic interventions, 1103 Clinical Sciences, Pneumonia, Odds ratio, medicine.disease, Good Health and Well Being, neoplasms/surgery, critical care/methods, Emergency medicine, postoperative complications/prevention & control, Neoplasm, Postoperative Complication, Cohort Studie, business, aged, 80 and over, SARS-CoV-2/physiology, logistic models
Abstract: PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks. Copyright © 2020 American Society of Clinical Oncology. All rights reserved. Bowel and Cancer Research; Sarcoma UK; Yorkshire Cancer Research; European Society of Coloproctology; National Institute for Health Research: 16.136.79; Bowel Disease Research Foundation; Urology Foundation Supported by a National Institute for Health Research (NIHR) Global Health Research Unit grant (NIHR 16.136.79) using UK aid from the UK government to support global health research, Association of Coloproctology of Great Britain and Ireland, Bowel & Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research. The funders had no role in the study design; data collection, analysis, and interpretation; or writing of this report. The views expressed are those of the authors and not necessarily those of the National Health Service, NIHR, or UK Department of Health and Social Care.
Published: 2021

20. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study

Author: Bourne R. R. A., Steinmetz J. D., Saylan M., Mersha A. M., Weldemariam A. H., Wondmeneh T. G., Sreeramareddy C. T., Pinheiro M., Yaseri M., Yu C., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Zimsen S. R. M., Yonemoto N., Tsegaye G. W., Vu G. T., Vongpradith A., Renzaho A. M. N., Sorrie M. B., Shaheen A. A., Shiferaw W. S., Skryabin V. Y., Skryabina A. A., Saya G. K., Rahimi-Movaghar V., Shigematsu M., Sahraian M. A., Naderifar H., Sabour S., Rathi P., Sathian B., Miller T. R., Rezapour A., Rawal L., Pham H. Q., Parekh U., Podder V., Onwujekwe O. E., Pasovic M., Otstavnov N., Negash H., Pawar S., Naimzada M. D., Al Montasir A., Ogbo F. A., Owolabi M. O., Pakshir K., Mohammad Y., Moni M. A., Nunez-Samudio V., Mulaw G. F., Naveed M., Maleki S., Michalek I. M., Misra S., Swamy S. N., Mohammed J. A., Flaxman S., Park E. -C., Briant P. S., Meles G. G., Hayat K., Landires I., Kim G. R., Liu X., LeGrand K. E., Taylor H. R., Kunjathur S. M., Khoja T. A. M., Bicer B. K., Khalilov R., Hashi A., Kayode G. A., Carneiro V. L. A., Kavetskyy T., Kosen S., Kulkarni V., Holla R., Kalhor R., Jayaram S., Islam S. M. S., Gilani S. A., Eskandarieh S., Molla M. D., Itumalla R., Farzadfar F., Congdon N. G., Elhabashy H. R., Elayedath R., Couto R. A. S., Dervenis N., Cromwell E. A., Dahlawi S. M. A., Resnikoff S., Casson R. J., Abdoli A., Choi J. -Y. J., Dos Santos F. L. C., Abrha W. A., Nagaraja S. B., Abualhasan A., Adal T. G., Aregawi B. B., Beheshti M., Abu-Gharbieh E., Afshin A., Ahmadieh H., Alemzadeh S. A., Arrigo A., Atnafu D. D., Ashbaugh C., Ashrafi E., Alemayehu W., Alfaar A. S., Alipour V., Anbesu E. W., Androudi S., Arabloo J., Arditi A., Bagli E., Baig A. A., Barnighausen T. W., Battaglia Parodi M., Bhagavathula A. S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A. M., Butt Z. A., Cheng C. -Y., Chu D. -T., Cicinelli M. V., Coelho J. M., Dai X., Dana R., Dandona L., Dandona R., Del Monte M. A., Deva J. P., Diaz D., Djalalinia S., Dreer L. E., Ehrlich J. R., Ellwein L. B., Emamian M. H., Fernandes A. G., Fischer F., Friedman D. S., Furtado J. M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B. R., Hartnett M. E. R., Hartono R. K., Hay S. I., Heidari G., Ho H. C., Househ M., Ibitoye S. E., Ilic I. M., Huang J. J., Ilic M. D., Ingram A. D., Irvani S. S. N., Jha R. P., Kahloun R., Kandel H., Kasa A. S., Kempen J. H., Khairallah M., Khan E. A., Khanna R. C., Khatib M. N., Kim J. E., Kim Y. J., Kisa A., Kisa S., Koyanagi A., Kurmi O. P., Lansingh V. C., Leasher J. L., Leveziel N., Limburg H., Manafi N., Mansouri K., McAlinden C., Mohammadi S. F., Mokdad A. H., Morse A. R., Naderi M., Naidoo K. S., Nangia V., Nguyen H. L. T., Ogundimu K., Olagunju A. T., Panda-Jonas S., Pesudovs K., Peto T., Ur Rahman M. H., Ramulu P. Y., Rawaf D. L., Rawaf S., Reinig N., Robin A. L., Rossetti L., Safi S., Sahebkar A., Samy A. M., Serle J. B., Shaikh M. A., Shen T. T., Shibuya K., Shin J. I., Silva J. C., Silvester A., Singh J. A., Singhal D., Sitorus R. S., Skiadaresi E., Soheili A., Sousa R. A. R. C., Stambolian D., Tadesse E. G., Tahhan N., Tareque Md. I., Topouzis F., Tran B. X., Tsilimbaris M. K., Varma R., Virgili G., Wang N., Wang Y. X., West S. K., Wong T. Y., Jonas J. B., Vos T., Bourne, R. R. A., Steinmetz, J. D., Saylan, M., Mersha, A. M., Weldemariam, A. H., Wondmeneh, T. G., Sreeramareddy, C. T., Pinheiro, M., Yaseri, M., Yu, C., Zastrozhin, M. S., Zastrozhina, A., Zhang, Z. -J., Zimsen, S. R. M., Yonemoto, N., Tsegaye, G. W., Vu, G. T., Vongpradith, A., Renzaho, A. M. N., Sorrie, M. B., Shaheen, A. A., Shiferaw, W. S., Skryabin, V. Y., Skryabina, A. A., Saya, G. K., Rahimi-Movaghar, V., Shigematsu, M., Sahraian, M. A., Naderifar, H., Sabour, S., Rathi, P., Sathian, B., Miller, T. R., Rezapour, A., Rawal, L., Pham, H. Q., Parekh, U., Podder, V., Onwujekwe, O. E., Pasovic, M., Otstavnov, N., Negash, H., Pawar, S., Naimzada, M. D., Al Montasir, A., Ogbo, F. A., Owolabi, M. O., Pakshir, K., Mohammad, Y., Moni, M. A., Nunez-Samudio, V., Mulaw, G. F., Naveed, M., Maleki, S., Michalek, I. M., Misra, S., Swamy, S. N., Mohammed, J. A., Flaxman, S., Park, E. -C., Briant, P. S., Meles, G. G., Hayat, K., Landires, I., Kim, G. R., Liu, X., Legrand, K. E., Taylor, H. R., Kunjathur, S. M., Khoja, T. A. M., Bicer, B. K., Khalilov, R., Hashi, A., Kayode, G. A., Carneiro, V. L. A., Kavetskyy, T., Kosen, S., Kulkarni, V., Holla, R., Kalhor, R., Jayaram, S., Islam, S. M. S., Gilani, S. A., Eskandarieh, S., Molla, M. D., Itumalla, R., Farzadfar, F., Congdon, N. G., Elhabashy, H. R., Elayedath, R., Couto, R. A. S., Dervenis, N., Cromwell, E. A., Dahlawi, S. M. A., Resnikoff, S., Casson, R. J., Abdoli, A., Choi, J. -Y. J., Dos Santos, F. L. C., Abrha, W. A., Nagaraja, S. B., Abualhasan, A., Adal, T. G., Aregawi, B. B., Beheshti, M., Abu-Gharbieh, E., Afshin, A., Ahmadieh, H., Alemzadeh, S. A., Arrigo, A., Atnafu, D. D., Ashbaugh, C., Ashrafi, E., Alemayehu, W., Alfaar, A. S., Alipour, V., Anbesu, E. W., Androudi, S., Arabloo, J., Arditi, A., Bagli, E., Baig, A. A., Barnighausen, T. W., Battaglia Parodi, M., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bijani, A., Bikbov, M., Bottone, M., Braithwaite, T., Bron, A. M., Butt, Z. A., Cheng, C. -Y., Chu, D. -T., Cicinelli, M. V., Coelho, J. M., Dai, X., Dana, R., Dandona, L., Dandona, R., Del Monte, M. A., Deva, J. P., Diaz, D., Djalalinia, S., Dreer, L. E., Ehrlich, J. R., Ellwein, L. B., Emamian, M. H., Fernandes, A. G., Fischer, F., Friedman, D. S., Furtado, J. M., Gaidhane, S., Gazzard, G., Gebremichael, B., George, R., Ghashghaee, A., Golechha, M., Hamidi, S., Hammond, B. R., Hartnett, M. E. R., Hartono, R. K., Hay, S. I., Heidari, G., Ho, H. C., Househ, M., Ibitoye, S. E., Ilic, I. M., Huang, J. J., Ilic, M. D., Ingram, A. D., Irvani, S. S. N., Jha, R. P., Kahloun, R., Kandel, H., Kasa, A. S., Kempen, J. H., Khairallah, M., Khan, E. A., Khanna, R. C., Khatib, M. N., Kim, J. E., Kim, Y. J., Kisa, A., Kisa, S., Koyanagi, A., Kurmi, O. P., Lansingh, V. C., Leasher, J. L., Leveziel, N., Limburg, H., Manafi, N., Mansouri, K., Mcalinden, C., Mohammadi, S. F., Mokdad, A. H., Morse, A. R., Naderi, M., Naidoo, K. S., Nangia, V., Nguyen, H. L. T., Ogundimu, K., Olagunju, A. T., Panda-Jonas, S., Pesudovs, K., Peto, T., Ur Rahman, M. H., Ramulu, P. Y., Rawaf, D. L., Rawaf, S., Reinig, N., Robin, A. L., Rossetti, L., Safi, S., Sahebkar, A., Samy, A. M., Serle, J. B., Shaikh, M. A., Shen, T. T., Shibuya, K., Shin, J. I., Silva, J. C., Silvester, A., Singh, J. A., Singhal, D., Sitorus, R. S., Skiadaresi, E., Soheili, A., Sousa, R. A. R. C., Stambolian, D., Tadesse, E. G., Tahhan, N., Tareque, Md. I., Topouzis, F., Tran, B. X., Tsilimbaris, M. K., Varma, R., Virgili, G., Wang, N., Wang, Y. X., West, S. K., Wong, T. Y., Jonas, J. B., Vos, T., University of Washington [Seattle], Anglia Ruskin University (ARU), Imperial College London, University of Melbourne, Heidelberg University, Jahrom University of Medical Sciences, Aksum University, Cairo University, University of Sharjah, Wolkite University, Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Shahid Beheshti University, The Fred Hollows Foundation, Iran University of Medical Sciences, University of Leipzig Medical Center, University of Thessaly [Volos] (UTH), Visibility Metrics LLC, Adigrat University, San Raffaele Hospital, Tehran University of Medical Sciences (TUMS), Bahir Dar University (BDU), University Hospital of Ioannina, Sultan Zainal Abidin University, Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Charles University [Prague] (CU), Government Medical College Pali, All India Institute of Medical Sciences, National Institute of Biomedical Genomics, Babol University of Medical Sciences, Ufa Eye Research Institute, ondon School of Hygiene & Tropical Medicine, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Employee State Insurance Post Graduate Institute of Medical Sciences and Research, University of Waterloo [Waterloo], Federal Polytechnic School of Lausanne, University of Minho, University of Adelaide, Singapore Eye Research Institute [Singapore] (SERI), Seoul National University Hospital, Hanoi National University of Education (HNUE), IRCCS San Raffaele Scientific Institute [Milan, Italie], University of Porto, Queen's University [Belfast] (QUB), University of Dammam - Imam Abdulrahman Bin Faisal University, Harvard University, University of Michigan [Ann Arbor], University of Michigan System, University of Gondar, Royal Liverpool University Hospital, Universiti Tunku Abdul Rahman (UTAR), National Autonomous University of Mexico (UNAM), Ministry of Health and Medical Education [Iran] (MOHME), Mahatma Gandhi University of Medical Sciences and Technology, Cairo University - Faculty of Medicine, National Institutes of Health [Bethesda] (NIH), Shahroud University of Medical Sciences, Federal University of Sao Paulo (Unifesp), University of Applied Sciences Ravensburg-Weingarten, University of São Paulo (USP), Datta Meghe Institute of Medical Sciences, University College of London [London] (UCL), Haramaya University, Sankara Nethralaya Medical Research Foundation, The University of Lahore, Indian Institute of Public Health Gandhinagar, Hamdan Bin Mohammed Smart University, University of Georgia, University of Utah, Institution of Public Health Sciences, Jigjiga Universit, University of Veterinary and Animal Sciences, Independent Consultant, The Chinese University of Hong Kong [Hong Kong], Manipal academy of Higher Education, Hamad Bin Khalifa University (HBKU), Yale University [New Haven], University of Ibadan, University of Belgrade [Belgrade], Faculty of Science of the University of Kragujevac, University of Kragujevac, Deakin University, Burwood, Australia, Deakin University [Burwood], University of Hail, Mysore Medical College, Banaras Hindu University [Varanasi] (BHU), Ophtalmologistes Associe Monastir, Qazvin University of Medical Sciences, The University of Sydney, John Paul II Catholic University of Lublin (KUL), Institute of Human Virology [Nigeria] (IHVN), Myungsung Medical College, Centre Hospitalier Universitaire Fattouma Bourguiba, Partenaires INRAE, Baku State University, Health Services Academy, L V Prasad Eye Institute, Health Ministers Council Gulf Cooperative Council Stat, Medical College of Wisconsin [Milwaukee] (MCW), Xiamen University Malaysia, Yonsei University, Oslo Metropolitan University (OsloMet), School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia, Brien Holden Vision Institute, Fondation Théa, The Fred Hollows Foundation, Bill & Melinda Gates Foundation, Lions Clubs International Foundation, Sightsavers International, and University of Heidelberg., and GBD 2019 Blindness and Vision Impairment Collaborators* on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study.
Subjects: Pediatrics, medicine.medical_specialty, Refractive error, Visual acuity, genetic structures, Eye disease, 030231 tropical medicine, Population, Glaucoma, 03 medical and health sciences, 0302 clinical medicine, medicine, Global health, 030212 general & internal medicine, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, education, education.field_of_study, business.industry, Articles, General Medicine, Diabetic retinopathy, Macular degeneration, medicine.disease, eye diseases, 3. Good health, medicine.symptom, business
Abstract: Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidable vision impairment, defined as cataract and undercorrected refractive error. Methods: We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from
Published: 2021

21. Injuries and Concussions in Female High School Rugby: Prevention is Worth a Try

Author: Brent E Hagel, Isla Shill, Kathryn J Schneider, Amanda M Black, Kati Pasanen, Stacy Sick, James Preston Wiley, Carolyn A. Emery, and Stephen W. West
Subjects: medicine.medical_specialty, business.industry, education, Time loss, Physical Therapy, Sports Therapy and Rehabilitation, Injury surveillance, medicine.disease, Confidence interval, Intervention (counseling), Mechanism of injury, Concussion, Physical therapy, medicine, Orthopedics and Sports Medicine, Prospective cohort study, business, Medical attention
Abstract: OBJECTIVES To describe injury and concussion rates and mechanisms in female high school rugby players. DESIGN Two-year prospective cohort study. SETTING High school rugby. PARTICIPANTS Participants included 214 female High school rugby players (year 1) and 207 female High school players (year 2) from the Calgary Senior High School Athletics Association 2018 and 2019 rugby competition. INTERVENTION None. MAIN OUTCOME MEASURES Match and training injury and concussion. Injury definition included any injury resulting in time loss, inability to complete a session, and/or requiring medical attention. Details of reported injuries were collected on injury report forms and validated by a certified athletic therapist on a validated online injury surveillance platform. Exposure hours for players were tracked using paper or virtual weekly exposure forms by team designates. RESULTS A match incidence rate (IR) = 93.7 injuries/1000 match hours (95% confidence intervals (CI): 78.6-11.7) and training IR = 5.3 injuries/1000 training hours (95% CI: 4.0-6.9) were estimated. The tackle accounted for 109 (70%) match and 37 (44%) training injuries. Tackling was the most frequent mechanism of injury (IR = 37.5 injuries/1000 match hours, 95% CI: 27.5-51.8 and 1.2 injuries/1000 training hours, 95% CI: 0.7-2.4). Sixty-two match concussions (IR = 37.5 concussions/1000 match hours, 95% CI: 26.8-52.3) and 16 training concussions (IR = 1.0 concussions/1000 training hours, 95% CI: 0.7-1.4) occurred. Of 78 reported concussions, 78% for match and 56% for training were physician diagnosed. Tackling was the most frequent mechanism of concussion in matches (IR = 18.1 concussions/1000 match hours, 95% CI:11.4-28.6). CONCLUSIONS Injury and concussion rates in female high school rugby are high. The tackle accounted for the highest proportion of injuries. Prevention strategies (eg, tackle policy change, tackle-training programs, and neuromuscular training) should be explored to increase sport safety.
Published: 2021

22. Screening of prototype antiseizure and anti‐inflammatory compounds in the Theiler's murine encephalomyelitis virus model of epilepsy

Author: Misty D. Smith, Karen S. Wilcox, Fabiola Vanegas, Kristina Johnson, Cameron S. Metcalf, Peter J. West, and Tristan K. Underwood
Subjects: Male, Phenytoin, Topiramate, Epilepsy, Tiagabine, Gabapentin, Lacosamide, business.industry, Anti-Inflammatory Agents, Pharmacology, medicine.disease, Disease Models, Animal, Mice, Neurology, Seizures, Theilovirus, medicine, Animals, Phenobarbital, Neurology (clinical), Levetiracetam, business, medicine.drug
Abstract: Objective Infection with Theiler's Murine Encephalomyelitis Virus (TMEV) in C57Bl/6J mice results in handling-induced seizures and is useful for evaluating compounds effective against infection-induced seizures. However, to date only a few compounds have been evaluated in this model, and a comprehensive study of antiseizure medications (ASMs) has not yet been performed. Furthermore, as the TMEV infection produces marked neuroinflammation, an evaluation of prototype anti-inflammatory compounds is needed as well. Methods Male C57Bl/6J mice were inoculated with TMEV (day 0) followed by daily administrations of test compounds (day 3-7) and subsequent handling sessions (day 3-7). Doses of ASMs, comprising several mechanistic classes, were selected based on previously published data demonstrating the effect of these compounds in reducing seizures in the 6 Hz model of pharmacoresistant seizures. Doses of anti-inflammatory compounds, comprising several mechanistic classes, were selected based on published evidence of reduction of inflammation or inflammation-related endpoints. Results Several prototype ASMs reduced acute seizures following TMEV infection: lacosamide, phenytoin, ezogabine, phenobarbital, tiagabine, gabapentin, levetiracetam, topiramate, and sodium valproate. Of these, phenobarbital and sodium valproate had the greatest effect (>95% seizure burden reduction). Prototype anti-inflammatory drugs celecoxib, dexamethasone, and prednisone also moderately reduced seizure burden. Significance The TMEV model is utilized by the Epilepsy Therapy Screening Program (ETSP) as a tool for evaluation of novel compounds. Compounds reducing seizures in the TMEV comprise distinct mechanistic classes, some with mechanisms of action that extend beyond traditional ASMs.
Published: 2021

23. New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis

Author: Boris Guennewig, Matt Keon, P Anthony Akkari, Bojan Petrović, Phillip K West, Samuel Brennan, Frances Theunissen, and Kosar Hooshmand
Subjects: medicine.medical_specialty, Neurology, Neurofilament, Cognitive Neuroscience, Review, Biology, Mitochondrion, Protein aggregation, Cellular and Molecular Neuroscience, medicine, Humans, Amyotrophic lateral sclerosis, Neurodegeneration, Cytoskeleton, RC346-429, Axonal transport, Motor Neurons, Gut microbiome, Neurodegenerative Diseases, medicine.disease, Mitochondria, nervous system, Axoplasmic transport, Neurology (clinical), Neurology. Diseases of the nervous system, Neuroscience
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axonal projections, which rely on the integrity of neuronal cytoskeleton and mitochondria to regulate energy requirements for maintaining axonal stability, anterograde and retrograde transport, and signaling between neurons. The formation of protein aggregates which contain cytoskeletal proteins, and mitochondrial dysfunction both have devastating effects on the function of neurons and are shared pathological features across several neurodegenerative conditions, including ALS, Alzheimer's disease, Parkinson's disease, Huntington’s disease and Charcot-Marie-Tooth disease. Furthermore, it is becoming increasingly clear that cytoskeletal integrity and mitochondrial function are intricately linked. Therefore, dysregulations of the cytoskeletal network and mitochondrial homeostasis and localization, may be common pathways in the initial steps of neurodegeneration. Here we review and discuss known contributors, including variants in genetic loci and aberrant protein activities, which modify cytoskeletal integrity, axonal transport and mitochondrial localization in ALS and have overlapping features with other neurodegenerative diseases. Additionally, we explore some emerging pathways that may contribute to this disruption in ALS.
Published: 2021

24. Sex differences in the behavioral and immune responses of mice to tumor growth and cancer therapy

Author: Bianca G. Ford, Cullen M. Taniguchi, Robert Dantzer, A. Phillip West, Jessica M. Moltenkine, and Elisabeth G. Vichaya
Subjects: Male, medicine.medical_treatment, Immunology, Physiology, Inflammation, Disease, Motor Activity, Article, Proinflammatory cytokine, Mice, Behavioral Neuroscience, Immune system, Animals, Humans, Medicine, Fatigue, Sex Characteristics, Endocrine and Autonomic Systems, business.industry, Head and neck cancer, Immunity, Cancer, Immunotherapy, medicine.disease, Mice, Inbred C57BL, Head and Neck Neoplasms, Papilloma, Female, medicine.symptom, business
Abstract: There is significant variability in the expression of cancer-related fatigue. Understanding the factors that account for this variation provide insight into the underlying mechanisms. One important, but often overlooked, variable is biological sex. While a few clinical studies have indicated that female patients report higher levels of fatigue, these studies are subject to potential socio-culture reporting biases. Only a limited number of preclinical studies have considered sex differences in animal model of fatigue and few have simultaneously considered both disease- and treatment-related factors. The present series of studies was initiated to address the current knowledge gap on the importance of sex differences in cancer-related fatigue. We selected a murine model of human papilloma virus-positive head and neck cancer based on heterotypic injection of the mEERL95 cell line that grows in both male and female mice and responds to a regimen of cisplatin plus irradiation. We also tested the impact of immunotherapy treatment targeting PD1. Voluntary wheel running was used to evaluate fatigue-like behavior. Male mice grew larger tumors than did female mice and showed more severe fatigue-like behavior. We confirmed that the tumor increased the expression of inflammatory cytokines in the liver, but no sex differences were observed. As a trend toward elevated Cd3 mRNA was observed in female mice, we tested the importance of T cells using female Rag2−/− mice. The Rag2−/− female mice had accelerated tumor growth and more severe fatigue-like behavior. In response to cisplatin alone non-tumor-bearing female mice showed a slower recovery of wheel running activity compared to males. However, in response to chemoradiation and anti-PD1 neutralizing antibody, tumor-bearing female mice showed a better tumor response to therapy than male mice, but no significant sex differences were observed for wheel running. These findings point to different mechanisms underlying tumor- and treatment-induced behavioral fatigue and indicate that the sex factor can intervene to modulate the expression of fatigue-like behavior in particular circumstances.
Published: 2021

25. Impact of the circadian clock on fibrinolysis and coagulation in healthy individuals and cardiovascular patients – A systematic review

Author: M.I. Schønsted, A.S. West, and Helle K. Iversen
Subjects: Circadian rhythm, Suprachiasmatic nucleus, business.industry, Fibrinolysis, medicine.medical_treatment, Circadian clock, Physiology, Thrombosis, Endogeny, Hematology, Cardiovascular disease, medicine.disease, Hypercoagulable states, Rhythm, medicine, business, Morning
Abstract: Introduction Human body functions exhibit a circadian rhythm generated in peripheral cells and synchronized by the suprachiasmatic nucleus (SCN), which mostly is entrained by the daily light/dark cycles. Activity, meals and posture are capable of interfering with the endogenous circadian rhythm of coagulation parameters. An increasing number of human disorders show a circadian component, and epidemiological studies find cardiovascular events to peak in the morning hours. The aim was to review the circadian rhythms impact on fibrinolysis and coagulation in healthy individuals and cardiovascular patients. Materials and methods A total number of 25 studies were identified where 8 enrolled cardiovascular patients with or without healthy individuals. Using a MeSH-search in MEDLINE PubMed. Only original peer-reviewed papers were included. Results Results showed substantial variance with respect to exhibition of circadian rhythms and/or peak/trough times. Circadian rhythms of fibrinolysis were less pronounced in cardiovascular patients than in healthy individuals with decreased levels in the morning hours compared to healthy inducing higher risk of blood clotting. Conclusions Because of small studied group sizes and failure to control for entraining factors, larger studies are needed to fully establish the effects of the circadian rhythm on especially coagulation. The findings of chronobiologic rhythms in coagulation and fibrinolysis could suggest a need for a chrono-pharmacological approach when treating/preventing cardiovascular diseases.
Published: 2021

26. Potential role of blood biomarkers in patients with fibromyalgia: a systematic review with meta-analysis

Author: Dion Diep, Dinesh Kumbhare, Felipe C. K. Duarte, Jasper Hung, Daniel W. D. West, Sreekant Damodara, P. Ravi Selvaganapathy, and Samah Hassan
Subjects: Oncology, medicine.medical_specialty, Fibromyalgia, Tumor Necrosis Factor-alpha, business.industry, medicine.disease, C-Reactive Protein, Anesthesiology and Pain Medicine, Neurology, Blood biomarkers, Meta-analysis, Internal medicine, Humans, Medicine, Neurology (clinical), Chronic Pain, business, Biomarkers
Abstract: Fibromyalgia (FM) is a complex chronic pain condition. Its symptoms are nonspecific, and to date, no objective test exists to confirm FM diagnosis. Potential objective measures include the circulating levels of blood biomarkers. This systematic review and meta-analysis aim to review studies assessing blood biomarkers' levels in patients with FM compared with healthy controls. We systematically searched the PubMed, MEDLINE, EMBASE, and PsycINFO databases. Fifty-four studies reporting the levels of biomarkers in blood in patients with FM were included. Data were extracted, and the methodological quality was assessed independently by 2 authors. The methodological quality of 9 studies (17%) was low. The results of most studies were not directly comparable given differences in methods and investigated target immune mediators. Thus, data from 40 studies only were meta-analyzed using a random-effects model. The meta-analysis showed that patients with FM had significantly lower levels of interleukin-1 β and higher levels of IL-6, IL-8, tumor necrosis factor-alpha, interferon gamma, C-reactive protein, and brain-derived neurotrophic factor compared with healthy controls. Nevertheless, this systematic literature review and meta-analysis could not support the notion that these blood biomarkers are specific biomarkers of FM. Our literature review, however, revealed that these same individual biomarkers may have the potential role of identifying underlying pathologies or other conditions that often coexist with FM. Future research is needed to evaluate the potential clinical value for these biomarkers while controlling for the various confounding variables.
Published: 2021

27. Single and Composite Endpoints of Within-Patient Improvement in Symptoms: Pooled Tanezumab Data in Patients with Osteoarthritis

Author: Francis Berenbaum, Isabelle Davignon, Christine R. West, Robert H. Dworkin, Thomas J. Schnitzer, Philip G. Conaghan, Davide Gatti, Lars Viktrup, Kenneth M. Verburg, Ruoyong Yang, Northwestern University Feinberg School of Medicine, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Leeds, University of Rochester Medical Center (URMC), Azienda Ospedaliera Universitaria Integrata of Verona, Pfizer, Eli Lilly and Company [Indianapolis], HAL-SU, Gestionnaire, Centre de Recherche Saint-Antoine (CR Saint-Antoine), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP]
Subjects: musculoskeletal diseases, medicine.medical_specialty, WOMAC, Tanezumab, Population, Pain, Osteoarthritis, Placebo, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Rheumatology, Internal medicine, medicine, Immunology and Allergy, education, Original Research, 030203 arthritis & rheumatology, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Functional status, Odds ratio, medicine.disease, 3. Good health, chemistry, Patient-reported outcome measures, Orthopedic surgery, Physical therapy, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract: Introduction: Combining measures of key core domains (especially pain and function) into a composite endpoint that requires each patient to meet a threshold of improvement for each domain provides information on multiple aspects of osteoarthritis within individual patients. This pooled analysis of two phase 3 studies (NCT02697773, NCT02709486) explored single and composite endpoints for assessing within-patient improvement in knee or hip osteoarthritis symptoms following subcutaneous administration of tanezumab or placebo. Methods: Endpoints at week 16 included proportions of responders (C 30% improvement) in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain, WOMAC Physical Function, WOMAC Pain/Function composite, and weekly average pain; and patient acceptable symptom state (PASS) composite responders, minimal clinically important improvement (MCII) composite responders, IntroductionCombining measures of key core domains (especially pain and function) into a composite endpoint that requires each patient to meet a threshold of improvement for each domain provides information on multiple aspects of osteoarthritis within individual patients. This pooled analysis of two phase 3 studies (NCT02697773, NCT02709486) explored single and composite endpoints for assessing within-patient improvement in knee or hip osteoarthritis symptoms following subcutaneous administration of tanezumab or placebo.MethodsEndpoints at week 16 included proportions of responders (≥ 30% improvement) in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain, WOMAC Physical Function, WOMAC Pain/Function composite, and weekly average pain; and patient acceptable symptom state (PASS) composite responders, minimal clinically important improvement (MCII) composite responders, Outcome Measures in Rheumatology-Osteoarthritis Research Society International (OMERACT-OARSI) responders, and sustained weekly average pain responders.ResultsPooled population comprised 1545 patients. Of patients who had a ≥ 30% improvement in WOMAC Pain and/or WOMAC Physical Function, 88.5% were WOMAC Pain/Function composite responders, 7.0% were WOMAC Pain (but not Function) responders, and 4.4% were WOMAC Function (but not Pain) responders. Of weekly average pain responders, 43.1% were PASS composite responders. Odds ratios (tanezumab 2.5 mg and 5 mg groups, respectively, vs placebo) were 1.75 and 1.86 (WOMAC Pain/Function composite responders), 1.41 and 1.65 (weekly average pain responders), 1.60 and 1.73 (PASS composite responders), 1.52 and 1.68 (MCII composite responders), 1.75 and 1.88 (OMERACT-OARSI responders), and 1.85 and 1.48 (sustained weekly average pain responders). Subgroup analyses suggested a greater magnitude of effect for patients with a knee index joint compared with hip on some endpoints.ConclusionResponders on single pain endpoints were in many cases also responders on function or composite endpoints. Separation of tanezumab from placebo was similar and consistent across single and composite endpoints.
Published: 2021

28. Feasibility study to assess the delivery of a novel isometric exercise intervention for people with stage 1 hypertension in the NHS: protocol for the IsoFIT-BP study including amendments to mitigate the risk of COVID-19

Author: Jonathan D. Wiles, John Darby, Timothy W. R. Doulton, Tracy Pellatt-Higgins, Melanie Rees-Roberts, Douglas MacInnes, Jamie M. O’Driscoll, Christopher K.T. Farmer, Alan West, Ellie Santer, Katerina Gousia, Vanessa Short, Katie Saxby, and Maggie Smith
Subjects: medicine.medical_specialty, Medicine (General), Population, Medicine (miscellaneous), Feasibility study, law.invention, Isometric exercise, Study Protocol, R5-920, Randomized controlled trial, law, Health care, Medicine, Attrition, Medical prescription, education, Exercise, education.field_of_study, business.industry, COVID-19, medicine.disease, Confidence interval, Blood pressure, Sample size determination, Hypertension, Physical therapy, business, General practice
Abstract: Background Hypertension (HTN) affects approximately 25% of the UK population and is a leading cause of mortality. Associated annual health care costs run into billions. National treatment guidance includes initial lifestyle advice, followed by anti-hypertensive medication if blood pressure (BP) remains high. However, adoption and adherence to recommended exercise guidelines, dietary advice and anti-hypertensive medication is poor. Four short bouts of isometric exercise (IE) performed 3 days per week (d/wk) at home elicits clinically significant reductions in BP in those with normal to high-normal BP. This study will determine the feasibility of delivering personalised IE to patients with stage 1 hypertension for whom lifestyle changes would be recommended before medication within NHS primary care. Methods This is a randomised controlled feasibility study. Participants were 18+ years, with stage 1 hypertension, not on anti-hypertensive medication and without significant medical contraindications. Trial arms will be standard lifestyle advice (control) or isometric wall squat exercise and standard lifestyle advice. Primary outcomes include the feasibility of healthcare professionals to deliver isometric exercise prescriptions in a primary care NHS setting and estimation of the variance of change in systolic BP. Secondary outcomes include accuracy of protocol delivery, execution of and adherence to protocol, recruitment rate, attrition, perception of intervention viability, cost, participant experience and accuracy of home BP. The study will last 18 months. Sample size of 100 participants (50 per arm) allows for 20% attrition and 6.5% incomplete data, based upon 74 (37 each arm) participants (two-sided 95% confidence interval, width of 1.33 and standard deviation of 4) completing 4 weeks. Ethical approval IRAS ID is 274676. Discussion Before the efficacy of this novel intervention to treat stage 1 hypertension can be investigated in any large randomised controlled trial, it is necessary to ascertain if it can be delivered and carried out in a NHS primary care setting. Findings could support IE viability as a prophylactic/alternative treatment option. Trial registration ISRCTN13472393, registered 18 August 2020
Published: 2021

29. External support factors utilized by patients in coping with cancer: a European perspective

Author: Manwa Hegde, Patricia Dobríková, Dana Stachurová, Daniel J. West, and Bernardo Ramirez
Subjects: Coping (psychology), medicine.medical_specialty, Social work, business.industry, Nursing research, Pain medicine, Cancer, Disease, medicine.disease, Psychotherapy, Oncology, Neoplasms, Surveys and Questionnaires, Family medicine, Adaptation, Psychological, Humans, Medicine, Stage (cooking), business, Referral and Consultation, Psychosocial
Abstract: The article presents the results of research on psychosocial aspects of living with cancer in the Slovak Republic focusing on hospitalized and outpatient cancer patients in treatment during the curative stage of the disease. Assessing cancer patient’s interest in receiving help from individual members of a multidisciplinary team was a part of the research. The research was done through a questionnaire designed to focus on individual psychosocial aspects of cancer treatment. The research sample included 67 hospitalized patients and 61 outpatients. Execution of research was conducted in the individual clinical workplaces. When calculating the interest of cancer patients in spiritual counseling during oncological treatment, hospitalized patients indicated significant interest (p = .014). Similarly, hospitalized patients indicated more interest in using psychological counseling (p = .040) as well as in consultation with the social worker with a significant difference of (p = .017). Interest in the aid of a physical therapist was exhibited more significantly with hospitalized patients (p = .000). Significant interest in hospitalized patients using additional members of the multidisciplinary team was statistically significant (p = .017). Outpatient cancer patients indicated significant interest in finding information about medical conditions on the Internet (p = .000). For items addressing an interest in meeting people with cancer in self-help groups, there was no significant difference between outpatient and hospital patients (p = .298) as with talking to other patients who had cancer (p = .207). External support factors are important in helping patients cope with cancer. Health professionals can help patients mitigate the various difficulties associated with cancer.
Published: 2021

30. Importance and Severity Dependence of Physical Activity by GPS-Tracked Location in Glaucoma Patients

Author: Tianjing Li, David S. Friedman, Sheila K. West, Catalina Garzon, Jennifer A. Schrack, Pradeep Y. Ramulu, Aleksandra Mihailovic, Jian-Yu E, and Laura N. Gitlin
Subjects: medicine.medical_specialty, Home environment, business.industry, Excursion, Physical activity, Glaucoma, medicine.disease, Confidence interval, Ophthalmology, Physical therapy, Medicine, Activity location, business, Prospective cohort study
Abstract: Purpose To quantify the association of visual field (VF) damage on physical activity away-from-home, per away-from-home excursion, and at-home. Design Prospective cohort study. Methods Among 229 participants with glaucoma or suspected glaucoma, the severity of VF damage was defined as average sensitivity within the integrated VF (IVF). Participants wore accelerometers and global positioning system trackers for 7 days to measure physical activity and characterize activity location. Multivariable negative binomial regressions were used to test whether away-from-home activity per day, physical activity per away-from-home excursion, and at-home activity per day varied by the severity of VF damage. Results Each 5-dB decrement in IVF sensitivity was associated with a lower number of away-from-home activities per day (18% less moderate and vigorous physical activity [MVPA] minutes/d, 95% confidence interval, 0.69-0.97) and physical activities per away-from-home excursion (20% less MVPA minutes/excursion, 95% confidence interval, 0.65-0.98). Similar findings were noted for other away-from-home activity measures (including active minutes/steps per day, or active minutes/steps per excursion). However, worse IVF sensitivity was not associated with measures of at-home activities (MVPA minutes/d, active minutes/d, and steps/d), time spent at or away from home, or excursions/wk (P > .1 for all). Conclusions Restriction of physical activity in more patients with severe glaucoma results mostly from activity restriction outside the home environment. These findings highlight the importance of maintaining a safe home environment (where activity is less restricted) and increasing confidence to perform activity, particular high-intensity activity, when leaving the home amongst patients with glaucoma.
Published: 2021

31. Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge in rats

Author: Jan Elaine Soriano, Erin Erskine, Christopher West, Aaron A. Phillips, Brian Hayes, Ryan E. Rosentreter, Malihe-Sadat Poormasjedi-Meibod, Berkeley A. Scott, David J. Granville, and Mary Fossey
Subjects: Male, Cardiac function curve, Middle Cerebral Artery, medicine.medical_specialty, Time Factors, Physiology, Thoracic Vertebrae, Ventricular Function, Left, Hypotension, Orthostatic, Orthostatic vital signs, Physiology (medical), Internal medicine, medicine, Animals, Rats, Wistar, Spinal cord injury, Spinal Cord Injuries, Lower Body Negative Pressure, business.industry, Hemodynamics, medicine.disease, Adaptation, Physiological, Disease Models, Animal, Spinal Cord, Cerebrovascular Circulation, Cardiology, Cardiology and Cardiovascular Medicine, business, Thoracic spinal cord injury
Abstract: Spinal cord injury (SCI) impairs the cardiovascular responses to postural challenge, leading to the development of orthostatic hypotension (OH). Here, we apply lower body negative pressure (LBNP) to rodents with high-level SCI to demonstrate the usefulness of LBNP as a model for experimental OH studies, and to explore the effect of simulated OH on cardiovascular and cerebrovascular function following SCI. Male Wistar rats (
Published: 2021

32. PRMT5 Promotes Symmetric Dimethylation of RNA Processing Proteins and Modulates Activated T Cell Alternative Splicing and Ca2+/NFAT Signaling

Author: Shouvonik Sengupta, Kelsi O West, Shridhar Sanghvi, Mireia Guerau-de-Arellano, Georgios Laliotis, Kristin L. Patrick, Harpreet Singh, Kristen W. Lynch, Laura M. Agosto, and Philip N. Tsichlis
Subjects: Chemistry, Cell growth, Protein arginine methyltransferase 5, T cell, Immunology, Alternative splicing, Experimental autoimmune encephalomyelitis, T-cell receptor, NFAT, General Medicine, medicine.disease, Cell biology, medicine.anatomical_structure, RNA splicing, medicine, Immunology and Allergy
Abstract: Protein arginine methyltransferase (PRMT) 5 is the type 2 methyltransferase catalyzing symmetric dimethylation of arginine. PRMT5 inhibition or deletion in CD4 Th cells reduces TCR engagement-induced IL-2 production and Th cell expansion and confers protection against experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. However, the mechanisms by which PRMT5 modulates Th cell proliferation are still not completely understood, and neither are the methylation targets in T cells. In this manuscript, we uncover the role of PRMT5 on alternative splicing in activated mouse T cells and identify several targets of PRMT5 symmetric dimethylation involved in splicing. In addition, we find a possible link between PRMT5-mediated alternative splicing of transient receptor potential cation channel subfamily M member 4 (Trpm4) and TCR/NFAT signaling/IL-2 production. This understanding may guide development of drugs targeting these processes to benefit patients with T cell–mediated diseases.
Published: 2021

33. Environmental Features Contributing to Falls in Persons With Vision Impairment: The Role of Home Lighting and Home Hazards

Author: Sheila K. West, Rhonda Miller, Pradeep Y. Ramulu, Aleksandra Mihailovic, David S. Friedman, Jian-Yu E, and Laura N. Gitlin
Subjects: 0303 health sciences, business.industry, Confounding, Glaucoma, medicine.disease, Comorbidity, Article, Home hazards, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, Stairs, 030221 ophthalmology & optometry, medicine, Humans, Female, Fall rate, Prospective Studies, Visual Fields, business, Lighting, Aged, 030304 developmental biology, Bedroom, Demography
Abstract: Purpose To evaluate whether home hazards and lighting levels are associated with higher fall rates in adults with varying degrees of visual field (VF) damage from glaucoma. Methods Participants with diagnosed or suspected glaucoma provided three years of prospective falls data via monthly falls diaries. A post-fall telephone questionnaire determined fall locations. Seven home areas were evaluated for hazards and lighting via an in-home assessment. Multivariate models adjusting for relevant confounders, including age, sex, comorbidity, and severity of VF damage, evaluated the influence of hazards and lighting on fall rates in each home region. Results Mean baseline age for the 170 participants was 71.0 (7.6) years and 78 (46%) of participants were female. Fifty-nine participants experienced a total of 83 home falls, with the greatest number of falls occurring on the indoor stairs (n = 24, 29%) and bedroom (n = 17, 21%). Neither the number nor the percentage of hazardous items graded as hazardous was associated with the rate of falls (P > .26). Each 10-fold increase in room lighting was associated with 35% fewer falls in that home region (P = .02). The relation between lighting and the rate of falls did not differ with the degree of visual field damage (P > .3), and a lower fall rate was noted with better lighting even in participants with mild or no VF damage (rate ratio = 0.52/10-fold better lighting; P = 0.01). Conclusions Fewer home falls were found with better lighting, but not with fewer home hazards. Lighting improvements at home may reduce fall rates in older adults. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.
Published: 2021

34. The Safety of Agalsidase Alfa Enzyme Replacement Therapy in Canadian Patients with Fabry Disease Following Implementation of a Bioreactor Process

Author: Daniel G. Bichet, Michael West, Aneal Khan, Lan Lan, Sandra Sirrs, Chantal F. Morel, and Adina Tocoian
Subjects: Canada, medicine.medical_specialty, Population, Vital signs, Disease, Bioreactors, Pharmacotherapy, Quality of life, Internal medicine, medicine, Animals, Humans, Enzyme Replacement Therapy, Original Research Article, Child, education, Adverse effect, Pharmacology, education.field_of_study, business.industry, Enzyme replacement therapy, Middle Aged, medicine.disease, Fabry disease, Recombinant Proteins, Isoenzymes, Treatment Outcome, alpha-Galactosidase, Quality of Life, Fabry Disease, business
Abstract: Background and Objective Fabry disease, an X-linked lysosomal storage disorder characterized by absent or reduced alpha-galactosidase activity, is a lifelong disease that impairs patients’ quality of life. Patients with Fabry disease have a considerably shortened lifespan, with mortality being mainly due to renal failure, cardiovascular disease, or cerebrovascular disease. Enzyme replacement therapy with agalsidase alfa has been shown to attenuate the renal, cardiovascular, and neuropathic disease progression associated with Fabry disease. The objective of this study was to investigate the safety of a new animal component-free version of agalsidase alfa. Methods A phase III/IV, open-label, single-arm, multicenter safety study was conducted in Canadian patients with Fabry disease between August 2011 and September 2017 as a regulatory requirement to assess the safety of agalsidase alfa produced using an animal component-free bioreactor process. Eligible patients had a documented diagnosis of Fabry disease and satisfied current Canadian guidelines for receiving enzyme replacement therapy for Fabry disease. Following treatment with animal component-free bioreactor-processed agalsidase alfa, treatment-emergent adverse events were monitored, and post hoc analyses of infusion-related reactions by antidrug antibody and neutralizing antibody statuses were conducted. The data were analyzed using descriptive statistics. Results A total of 167 patients (mean [standard deviation] age, 48.9 [14.8] years), including six pediatric patients (
Published: 2021

35. Changes in community providers' screening behaviours, referral practices, and clinical confidence following participation in an early psychosis educational campaign

Author: A. Simone Sanders, Megan Lilly, Heather Thibeau, Michelle L. West, Kristen A. Woodberry, Michelle Friedman-Yakoobian, Kelsey A. Johnson, Margaret Guyer, Emily Kline, Zachary B. Millman, and Matcheri S. Keshavan
Subjects: medicine.medical_specialty, Psychosis, Adolescent, Referral, business.industry, media_common.quotation_subject, Attendance, Specialty, medicine.disease, Outreach, Psychiatry and Mental health, Psychotic Disorders, Feeling, Surveys and Questionnaires, Family medicine, Intervention (counseling), medicine, Humans, Mass Screening, Quality (business), Pshychiatric Mental Health, business, Referral and Consultation, Biological Psychiatry, media_common
Abstract: AIM Successful delivery of care to individuals with early psychosis depends on the ability of community providers to identify and refer appropriate candidates for services. Although specialty centres commonly rely upon education and outreach campaigns to building bridges with community providers, few studies have examined the effectiveness of these campaigns or the mechanisms by which they may achieve their intended effects. METHODS We surveyed community clinicians (N = 39) about their screening behaviours, referral practices, and confidence in managing early psychosis just before and 3-6 months after attending an educational event designed to promote recognition and quality treatment of early psychosis. RESULTS Three to six months following attendance, providers reported screening a greater proportion of clients for early psychosis, referring a greater number of clients to specialty services, and feeling more confident in their ability to respond to clients with early psychosis. Increases in confidence following attendance were associated with corresponding increases in screening behaviour. CONCLUSIONS The results suggest that outreach campaigns designed to enhance community providers' knowledge about early psychosis assessment and resources may be effective in promoting screening, referrals, and confidence in managing psychosis. Gains in provider confidence may contribute to increases in screening. Given the lack of control group and relatively short follow-up period, more research is needed to determine the effects of early psychosis educational events and the mechanisms by which they may promote successful treatment delivery for young people in need.
Published: 2021

36. Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis

Author: Stewart J. Kim, Patrick Neuhöfer, Caitlin M. Roake, Ryan J. Lu, Robert B. West, Gregory W. Charville, and Steven E. Artandi
Subjects: Multidisciplinary, Transdifferentiation, Clone (cell biology), Biology, medicine.disease, medicine.disease_cause, medicine.anatomical_structure, stomatognathic system, Pancreatic cancer, medicine, Cancer research, Acinar cell, Telomerase reverse transcriptase, Stem cell, Carcinogenesis, Pancreas
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths worldwide1. Studies in human tissues and in mouse models have suggested that for many cancers, stem cells sustain early mutations driving tumour development2,3. For the pancreas, however, mechanisms underlying cellular renewal and initiation of PDAC remain unresolved. Here, using lineage tracing from the endogenous telomerase reverse transcriptase (Tert) locus, we identify a rare TERT-positive subpopulation of pancreatic acinar cells dispersed throughout the exocrine compartment. During homeostasis, these TERThigh acinar cells renew the pancreas by forming expanding clones of acinar cells, whereas randomly marked acinar cells do not form these clones. Specific expression of mutant Kras in TERThigh acinar cells accelerates acinar clone formation and causes transdifferentiation to ductal pre-invasive pancreatic intraepithelial neoplasms by upregulating Ras–MAPK signalling and activating the downstream kinase ERK (phospho-ERK). In resected human pancreatic neoplasms, we find that foci of phospho-ERK-positive acinar cells are common and frequently contain activating KRAS mutations, suggesting that these acinar regions represent an early cancer precursor lesion. These data support a model in which rare TERThigh acinar cells may sustain KRAS mutations, driving acinar cell expansion and creating a field of aberrant cells initiating pancreatic tumorigenesis. A rare population of acinar cells expressing telomerase reverse transcriptase renew the acinar cell compartment during homeostasis, and are potential sources of premalignant cells in pancreatic carcinogenesis.
Published: 2021

37. Hospital at Home: An Evolving Model for Comprehensive Healthcare

Author: Henil Y. Patel and Daniel J. West
Subjects: business.industry, Health care, Medicine, Medical emergency, business, medicine.disease
Abstract: Hospital at Home (HaH) is a sustainable, innovative, and next-generation model of healthcare. From the healthcare management point of view, this model provides cost benefits and quality improvement, and from the physicians' point of view, it helps in providing patient-centered medical care and keeps patients away from hospital admission and its complications. The HaH model was first introduced at John Hopkins in the United States in 1995, which showed very promising results in context to the length of stay, readmission rates, patient satisfaction, and hospital-acquired infections. The HaH model of care provides acute critical care to patients at home and reduces unnecessary hospitalization and related complications. The identified patients for this model of care are elderly patients with chronic conditions and multiple comorbidities. The emergence of technology in today's world and the impact of coronavirus disease 2019 (COVID-19) have increased the demand for the HaH model of care. Although there are many benefits and advantages, the HaH model of care has significant barriers and limitations, such as reimbursement for payment, physician and patient resistance, patient safety, and lack of quantifying research data to support the use of this model. Specific training for the physician, nursing, and other members of the HaH multidisciplinary team is necessary for HaH treatment protocols, along with patient and family caregiver education for those who elect the HaH model of care. HaH is the future of comprehensive healthcare services and helps in achieving the triple aim of access to healthcare, improved quality of care, and reduced cost for healthcare.
Published: 2021

38. Interobserver variation in the classification of tumor deposits in rectal cancer—is the use of histopathological characteristics the way to go?

Author: Nicholas P. West, A Martinez, M Terlizzo, Marco Novelli, Nelleke P.M. Brouwer, Graham Brown, A C Lord, Adrian C Bateman, Iris D. Nagtegaal, Robert D. Goldin, and Newton A C S Wong
Subjects: medicine.medical_specialty, Colorectal cancer, Biopsy, medicine.medical_treatment, TNM staging, Perineural invasion, Histopathology, Tumor deposit, Pathology and Forensic Medicine, Predictive Value of Tests, medicine, Humans, Venous Invasion, Rectal cancer, Molecular Biology, Lymph node, Neoadjuvant therapy, Neoplasm Staging, Retrospective Studies, Extranodal Extension, Observer Variation, Lymph node metastasis, Clinical Trials as Topic, Rectal Neoplasms, business.industry, Reproducibility of Results, Nodule (medicine), Cell Biology, General Medicine, medicine.disease, Pathologists, medicine.anatomical_structure, England, Lymphatic Metastasis, Interobserver Variation, Original Article, Clinical Competence, Radiology, Interobserver variability, medicine.symptom, business
Abstract: The focus on lymph node metastases (LNM) as the most important prognostic marker in colorectal cancer (CRC) has been challenged by the finding that other types of locoregional spread, including tumor deposits (TDs), extramural venous invasion (EMVI), and perineural invasion (PNI), also have significant impact. However, there are concerns about interobserver variation when differentiating between these features. Therefore, this study analyzed interobserver agreement between pathologists when assessing routine tumor nodules based on TNM 8. Electronic slides of 50 tumor nodules that were not treated with neoadjuvant therapy were reviewed by 8 gastrointestinal pathologists. They were asked to classify each nodule as TD, LNM, EMVI, or PNI, and to list which histological discriminatory features were present. There was overall agreement of 73.5% (κ 0.38, 95%-CI 0.33–0.43) if a nodal versus non-nodal classification was used, and 52.2% (κ 0.27, 95%-CI 0.23–0.31) if EMVI and PNI were classified separately. The interobserver agreement varied significantly between discriminatory features from κ 0.64 (95%-CI 0.58–0.70) for roundness to κ 0.26 (95%-CI 0.12–0.41) for a lone arteriole sign, and the presence of discriminatory features did not always correlate with the final classification. Since extranodal pathways of spread are prognostically relevant, classification of tumor nodules is important. There is currently no evidence for the prognostic relevance of the origin of TD, and although some histopathological characteristics showed good interobserver agreement, these are often non-specific. To optimize interobserver agreement, we recommend a binary classification of nodal versus extranodal tumor nodules which is based on prognostic evidence and yields good overall agreement. Supplementary Information The online version contains supplementary material available at 10.1007/s00428-021-03197-0.
Published: 2021

39. Sleep-disordered breathing and cerebral small vessel disease—acute and 6 months after ischemic stroke

Author: Helle K. Iversen, Frauke Wolfram, Adam Vittrup Andersen, Sofie Amalie Simonsen, Anders Sode West, and Poul Jennum
Subjects: Adult, Male, TOAST Classification, medicine.medical_specialty, Neurology, Polysomnography, Sleep Apnea Syndromes, Internal medicine, medicine, Humans, cardiovascular diseases, Stroke, Aged, Ischemic Stroke, Aged, 80 and over, medicine.diagnostic_test, business.industry, Sleep apnea, Middle Aged, medicine.disease, Confidence interval, nervous system diseases, respiratory tract diseases, Otorhinolaryngology, Cerebral Small Vessel Diseases, Breathing, Etiology, Cardiology, Female, Neurology (clinical), business
Abstract: Sleep-disordered breathing (SDB) occurs frequently after stroke and is associated with poor functional outcome and increased mortality. The purpose of this study was to detect changes in SDB over time after acute ischemic stroke and investigate relationships between SDB and stroke etiologies with focus on cerebral small vessel disease. From May 2015 to August 2016, we conducted an observational study of 99 patients with mild to moderate stroke (median age: 68 years, range 36–88; 56% men). Polysomnography was performed within 7 days of stroke onset (n = 91) and after 6 months (n = 52). The strokes were classified using the etiological TOAST classification. Total small vessel disease (SVD) scores were calculated based on MRIs. SDB, defined as an apnea–hypopnea index (AHI) ≥ 15, was found in 56% of patients in the acute state and in 44% at follow-up. AHI decreased over time (median change 4.7, 95% confidence interval [95% CI] 0.5–8.9; p = 0.03). Patients with AHI ≥ 15 in both the acute state and at follow-up had higher SVD score at follow-up (p = 0.003). AHI was not associated with ischemic stroke subgroups according to the TOAST classification. In conclusion, 6 months after stroke, AHI decreased, but 44% still had AHI ≥ 15. Persistent SDB in both the acute state and at follow-up was associated with a higher SVD score, but not to the TOAST subgroups. SDB evaluation should be offered to stroke patients, and the effect of SDB on cerebral small vessel disease needs to be further investigated using the well-defined SVD score. clinicaltrials.gov NCT02111408, April 11, 2014
Published: 2021

40. Coronary Artery Disease in Young Women After Radiation Therapy for Breast Cancer

Author: Lisa L. Hunter, Gordon P. Watt, Cecilia A. O'Brien, Rebecca M. Howell, John D. Boice, Laura Cervino, Meghan Woods, Marilyn Stovall, Eric J. Chow, Kathleen E. Malone, Judy Goldstein, Michele M. West, Xiaolin Liang, Lene Mellemkjӕr, Lawrence T. Dauer, Charles F. Lynch, Lauren E. Carlson, Emily S. Tonorezos, Roy E. Shore, Leslie Bernstein, Mark E. Robson, Rikke Langballe, Anne S. Reiner, Marinela Capanu, Anthony F. Yu, Jonine L. Bernstein, Irene Orlow, Susan A. Smith, Jennifer D. Brooks, Jørgen H. Olsen, Kristina M. Blackmore, Esther M. John, Rita E. Weathers, Irene Harris, Julia A. Knight, and Elaine Ramos
Subjects: medicine.medical_specialty, medicine.medical_treatment, BMI, body mass index, CAD, coronary artery disease, CAD - Coronary artery disease, Coronary artery disease, Breast cancer, prevention, Internal medicine, Epidemiology, Mini-Focus Issue: Radiation and Cardiovascular Disease, Medicine, Risk factor, skin and connective tissue diseases, Original Research, Ischemic disease, treatment, business.industry, RT, radiation therapy, medicine.disease, Radiation therapy, Oncology, risk factor, women’s oncology, Cardiology, epidemiology, ischemic disease, Cardiology and Cardiovascular Medicine, business, BMI - Body mass index
Abstract: Background Radiation therapy (RT) for breast cancer increases risk of coronary artery disease (CAD). Women treated for left- vs right-sided breast cancer receive greater heart radiation exposure, which may further increase this risk. The risk of radiation-associated CAD specifically among younger breast cancer survivors is not well defined. Objectives The purpose of this study was to report CAD risk among participants in the Women’s Environmental Cancer and Radiation Epidemiology Study. Methods A total of 1,583 women who were, Central Illustration
Published: 2021

41. Understanding and Overcoming the Challenges Related to Cardiovascular Trials Involving Patients with Kidney Disease

Author: Cynthia Chauhan, Julie H. Ishida, David C. Wheeler, Meaghan A. Malley, Ken Gruchalla, Barbara S. Gillespie, Melissa West, Peter A. McCullough, Susan Quella, Patrick Rossignol, Charles A. Herzog, and Alain Romero
Subjects: Feature, Nephrology, medicine.medical_specialty, Epidemiology, Population, Psychological intervention, Disease, Critical Care and Intensive Care Medicine, Internal medicine, medicine, Humans, education, Intensive care medicine, Clinical Trials as Topic, Transplantation, education.field_of_study, business.industry, Patient Selection, medicine.disease, Comorbidity, Clinical trial, Systematic review, Cardiovascular Diseases, Research Design, Kidney Diseases, business, Kidney disease
Abstract: Cardiovascular disease is a prevalent and prognostically important comorbidity among patients with kidney disease, and individuals with kidney disease make up a sizeable proportion (30%-60%) of patients with cardiovascular disease. However, several systematic reviews of cardiovascular trials have observed that patients with kidney disease, particularly those with advanced kidney disease, are often excluded from trial participation. Thus, currently available trial data for cardiovascular interventions in patients with kidney disease may be insufficient to make recommendations on the optimal approach for many therapies. The Kidney Health Initiative, a public-private partnership between the American Society of Nephrology and the US Food and Drug Administration, convened a multidisciplinary, international work group and hosted a stakeholder workshop intended to understand and develop strategies for overcoming the challenges with involving patients with kidney disease in cardiovascular clinical trials, with a particular focus on those with advanced disease. These efforts considered perspectives from stakeholders, including academia, industry, contract research organizations, regulatory agencies, patients, and care partners. This article outlines the key challenges and potential solutions discussed during the workshop centered on the following areas for improvement: building the business case, re-examining study design and implementation, and changing the clinical trial culture in nephrology. Regulatory and financial incentives could serve to mitigate financial concerns with involving patients with kidney disease in cardiovascular trials. Concerns that their inclusion could affect efficacy or safety results could be addressed through thoughtful approaches to study design and risk mitigation strategies. Finally, there is a need for closer collaboration between nephrologists and cardiologists and systemic change within the nephrology community such that participation of patients with kidney disease in clinical trials is prioritized. Ultimately, greater participation of patients with kidney disease in cardiovascular trials will help build the evidence base to guide optimal management of cardiovascular disease for this population.
Published: 2021

42. Challenges Faced by Women with Cystic Fibrosis

Author: Traci M. Kazmerski, Kubra Melike Bozkanat, Moira L. Aitken, Jennifer L. Taylor-Cousar, Maddie Poranski, Jacqui Sjoberg, Raksha Jain, Kristina Montemayor, Natalie E. West, Alexandra Wilson, and Karen von Berg
Subjects: Pulmonary and Respiratory Medicine, Infertility, Gerontology, Pregnancy, Cystic Fibrosis, business.industry, Osteoporosis, Urinary incontinence, medicine.disease, Cystic fibrosis, Menopause, Reproductive Health, medicine, Humans, Female, medicine.symptom, business, Reproductive health
Abstract: Women with cystic fibrosis (CF) face several unaddressed concerns related to their health. These areas of concern include explanations and guidance on a sex disparity in outcomes, timing of puberty, effects of contraception, prevalence of infertility and impact of pregnancy, and prevention of urinary incontinence and osteoporosis. These understudied topics leave women with numerous unanswered questions about how to manage sexual and reproductive health in the setting of CF. Because people with CF are living longer and healthier lives, there is an increasing awareness of these important aspects of care and multiple ongoing studies to address these understudied topics.
Published: 2021

43. Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing

Author: Sarah K. Wootton, Jakob M. Domm, Jeffrey A. Medin, and Michael West
Subjects: Endocrinology, Diabetes and Metabolism, Genetic enhancement, Gene delivery, Bioinformatics, Biochemistry, Endocrinology, Genome editing, Genetics, Lysosomal storage disease, Humans, Medicine, Molecular Biology, Gene, Gene Editing, biology, business.industry, Genetic disorder, Genetic Therapy, medicine.disease, biology.organism_classification, Fabry disease, Phenotype, alpha-Galactosidase, Mutation, Lentivirus, Fabry Disease, business
Abstract: Gene therapy is the delivery of a therapeutic gene for endogenous cellular expression with the goal of rescuing a disease phenotype. It has been used to treat an increasing number of human diseases with many strategies proving safe and efficacious in clinical trials. Gene delivery may be viral or non-viral, performed in vivo or ex vivo, and relies on gene integration or transient expression; all of these techniques have been applied to the treatment of Fabry disease. Fabry disease is a genetic disorder of the α-galactosidase A gene, GLA, that causes an accumulation of glycosphingolipids in cells leading to cardiac, renal and cerebrovascular damage and eventually death. Currently, there are no curative treatments available, and the therapies that are used have significant drawbacks. These treatment concerns have led to the advent of gene therapies for Fabry disease. The first Fabry patients to receive gene therapy were treated with recombinant lentivirus targeting their hematopoietic stem/progenitor cells. Adeno-associated virus treatments have also begun. Alternatively, the field of gene-editing is a new and rapidly growing field. Gene-editing has been used to repair disease-causing mutations or insert genes into cellular DNA. These techniques have the potential to be applied to the treatment of Fabry disease provided the concerns of gene-editing technology, such as safety and efficiency, were addressed. This review focuses on the current state of gene therapy as it is being developed for Fabry disease, including progresses and challenges as well as an overview of gene-editing and how it may be applied to correct Fabry disease-causing mutations in the future.
Published: 2021

44. Trauma Laparotomy in the UK: A Prospective National Service Evaluation

Author: Rebecca Badminton, Rebekka Troller, Bryony Roberts, David O’Reilly, Nick Moody, Emma Davies, Michael Thompson, Mihir Chandarana, Gary Maytham, Zane Perkins, Paul Vulliamy, Duncan Bew, Somayyeh Mossadegh, Iain M. Smith, Charles Bull, Michael Smith, Kirsty Challen, Gethin L. Williams, Helen Farrah, Jonathan Jones, Lorcan o Maoileannaigh, Stella Ruth Smith, Disha Mehta, Victoria Pegna, Adam Brooks, Harriet Owen, Anthony Thaventhiran, Ben Stubbs, Anna Sharrock, Kate Hancorn, Tony Sim, Johanna Paterson, Henry Obinna Nnajiuba, Seema Yalamanchili, Anitha Muthusami, David N. Naumann, Ben Griffiths, Ian Bailey, Jo Manson, Michael Wilson, Harsha Kodakadath, Ross Davenport, Maryam Alfa-Wali, Francis Ezidi, Charlotte Thompson, Olga Rutka, Kate Rej. Prior, Christine Hardcastle, Ewen A. Griffiths, Ibrahim Enemosah, Parv Sains, Charlotte Florence, Sam Docherty, Laura Evans, Max Marsden, Giles Bond-Smith, Chris Finnegan, Stavros Gourgiotis, Adam Gowdy, Natesh Shivakumar, Helen R Dorrance, Lewis S. Gall, Alexandra Chesworth, Raimundas Lunevicius, Michael Greenway, Adeel Akhtar, Oliver Harrison, Callum T. Kaye, Mark Winstanley, Lauren Blackburn, Maria Bassett-Davies, Colin Bergin, Stuart McKechnie, Christopher Briggs, Joseph Hardwicke, Daniel McGeown, Charles A. West, Jon Moore, Alexander Bell, Julian Thompson, Paul Farrelly, Amar Kourdouli, Andrea Rossetto, Phillip Pearce, Nicola Lipscombe, Una Cronin, Alice Graham, Rebecca Varley, Elizabeth Vaughan, Jennifer Ross, Esau Moreno-Camacho, Mari-Claire McGuigan, Jack Navein, Emma Stewart Parker, Alan Watts, Ashish Shrestha, Mansoor Khan, Rich Carden, Laura Jayne Watson, Nabeela S. Malik, Nigel Tai, Michael Daley, and Tom Cowlam
Subjects: Adult, Male, medicine.medical_specialty, Blood transfusion, medicine.medical_treatment, Abdominal Injuries, 03 medical and health sciences, 0302 clinical medicine, Trauma Centers, Interquartile range, Laparotomy, medicine, Humans, Prospective Studies, Quality Indicators, Health Care, business.industry, Major trauma, Mortality rate, Emergency department, Middle Aged, medicine.disease, United Kingdom, Blunt trauma, 030220 oncology & carcinogenesis, Emergency medicine, Injury Severity Score, Female, 030211 gastroenterology & hepatology, Surgery, Emergencies, business
Abstract: Background Trauma patients requiring abdominal operation have considerable morbidity and mortality, yet no specific quality indicators are measured in the trauma systems of the UK. The aims of this study were to describe the characteristics and outcomes of patients undergoing emergency abdominal operation and key processes of care. Study Design A prospective multicenter service evaluation was conducted within all of the major trauma centers in the UK. The study was conducted during 6 months beginning in January 2019. Patients of any age undergoing laparotomy or laparoscopy within 24 hours of injury were included. Existing standards for related emergent conditions were used. Results The study included 363 patients from 34 hospitals. The majority were young men with no comorbidities who required operation to control bleeding (51%). More than 90% received attending-delivered care in the emergency department (318 of 363) and operating room (321 of 363). The overall mortality rate was 9%. Patients with blunt trauma had a greater risk of death compared with patients with penetrating injuries (16.6% vs 3.8%; risk ratio 4.3; 95% CI, 2.0 to 9.4). Patients in which the Major Hemorrhage Protocol (MHP) was activated and who received a blood transfusion (n = 154) constituted a high-risk subgroup, accounting for 45% of the study cohort but 97% of deaths and 96% of blood components transfused. The MHP subgroup had expedited timelines from emergency department arrival to knife to skin (MHP: median 119 minutes [interquartile range 64 to 218 minutes] vs no MHP: median 211 minutes [interquartile range 135 to 425 minutes]; p Conclusions The majority of trauma patients requiring emergency abdominal operation received a high standard of expedited care in a maturing national trauma system. Despite this, mortality and resource use among high-risk patients remains considerable.
Published: 2021

45. Challenges faced during the COVID-19 pandemic by family carers of people living with dementia towards the end of life

Author: Nathan Davies, Kirsten Moore, Emily West, Elizabeth L Sampson, Narin Aker, Pushpa Nair, and Nuriye Kupeli
Subjects: medicine.medical_specialty, Health informatics, Health administration, Nursing, Agency (sociology), Pandemic, medicine, Humans, Dementia, Pandemics, SARS-CoV-2, business.industry, Health Policy, Nursing research, Public health, Research, COVID-19, medicine.disease, Death, Coronavirus, Place of care, Telephone support, Caregivers, Charities, Family carers, End of life, Concerns, Public aspects of medicine, RA1-1270, business, Decision making, Qualitative research
Abstract: Background People living with dementia account for a large proportion of deaths due to COVID-19. Family carers are faced with making significant and emotive decisions during the pandemic, including decisions about end of life. We aimed to explore the challenges faced by family carers of people living with dementia during the first wave of the COVID-19 pandemic in England, as reported by charity telephone support line staff, who were able to objectively discuss a range of different experiences of many different carers who call the helpline. In particular, we focussed on key concerns and areas of decision making at the end of life. Methods We conducted a qualitative study using semi-structured interviews with eight telephone support line staff from two UK based charities who support carers of people living with dementia and those at the end of life. Interviews were conducted in the first wave of the pandemic in England in May–June 2020. Results An overarching theme of uncertainty and reactivity during a crisis was identified, and within this, five main themes were identified: concerns about care transitions, uncertainty in engaging support and help, pandemic-motivated care planning, maintaining the wellbeing of the person living with dementia, and trust, loss of agency and confusion. Conclusions Family carers may be reluctant to seek support because of fear of what may happen to their relative, which may include hospitalisation and becoming ill with COVID-19, care home placement, or not being able to be with a relative at the end of life. In some cases, a lack of trust has developed, and instead carers are seeking support from alternative services they trust such as nationally known charities.This study was used to inform the development of a decision aid to support family carers making decisions about care for their relative with dementia during the pandemic, who the lack the capacity to make their own decisions.
Published: 2021

46. Well-Newborn Unit Director Experiences During the COVID-19 Pandemic: A BORN Study

Author: Dennis West, Jaspreet Loyal, and Elena Aragona
Subjects: Male, medicine.medical_specialty, Stress management, Bathing, Breastfeeding, Pediatrics, COVID-19 Testing, Pregnancy, Pandemic, medicine, Humans, Infection control, Pregnancy Complications, Infectious, Pandemics, Newborn screening, SARS-CoV-2, business.industry, Infant, Newborn, COVID-19, General Medicine, medicine.disease, Infectious Disease Transmission, Vertical, Breast Feeding, Family medicine, Pediatrics, Perinatology and Child Health, Female, business, Breast feeding
Abstract: BACKGROUND As coronavirus disease 2019 (COVID-19) spread across the country, well-newborn unit medical directors developed newborn care plans as guidelines and evidence evolved. We chose to examine approaches to newborn care during these early phases of the COVID-19 pandemic. METHODS An electronic survey was administered to well-newborn unit directors in a national network of US well-newborn units in May 2020. Respondents were asked about their approaches to testing, infection prevention, routine newborn care, discharge planning, breastfeeding, rounding, and teaching. RESULTS Of 107 sites, 65 (61%) respondents completed the survey. Respondents estimated a 1% positivity rate of 1198 newborns tested for COVID-19. Most sites (86%) performed universal maternal COVID-19 testing, and most (82%) tested newborns of COVID-19-positive mothers at 24 hours of life (75%). Infection prevention and visitation policies varied. Of respondents, in COVID-19-positive mothers, 28% permitted no visitors, 54% recommended rooming-in with the newborn, 55% encouraged breastfeeding at the breast, 38% deferred routine circumcisions of the newborn, 74% initiated immediate bathing of the newborn, 68% continued standard newborn screening, and 55% modified newborn follow-up plans. Medical directors reported adjustments to rounding and teaching workflow. Content analysis of free-text responses revealed themes related to challenges with changing recommendations, discomfort with mother-infant separation recommendations, innovations, and stress management. CONCLUSIONS Well-newborn units quickly adopted universal maternal testing and testing of exposed newborns. Despite guidelines, we identified variation in the care of newborns of COVID-19-positive mothers. Further investigation of these differences and newborn outcomes is warranted to develop best practices.
Published: 2021

47. Vitiligo, alkaptonuria, and nitisinone—A report of three families and review of the literature

Author: Leanne A. Evans, Elizabeth West, Lakshminarayan R. Ranganath, Milad Khedr, Helen Bygott, and Emily Luangrath
Subjects: vitiligo, medicine.medical_specialty, South asia, Nitisinone, Endocrinology, Diabetes and Metabolism, Case Report, Case Reports, Vitiligo, QH426-470, Biochemistry, Genetics and Molecular Biology (miscellaneous), nitisinone, Alkaptonuria, Diseases of the endocrine glands. Clinical endocrinology, chemistry.chemical_compound, Pharmacotherapy, Internal Medicine, medicine, Genetics, Homogentisic acid, Family history, Autoimmune disease, alkaptonuria, business.industry, proton‐pump inhibitors, homogentisic acid, medicine.disease, RC648-665, Dermatology, chemistry, business, tyrosine, medicine.drug
Abstract: Four patients, from three families, with alkaptonuria receiving 4‐hydroxyphenylpyruvate dioxygenase‐inhibiting nitisinone therapy, which lowers homogentisic acid and increases tyrosine, developed vitiligo. Three of the four patients were receiving nitisinone 2 mg daily, while the fourth was on 10 mg daily. All four patients were either receiving or had received transiently proton‐pump inhibitors as therapy for dyspepsia. The ages of the patients were 35, 42, 40, and 67 years, respectively. Three patients were men and one was a woman. All four patients were either taking a proton‐pump inhibitor or had been taking one at some point. Three of the four were of South Asian and one of Caucasian background. The three patients with South Asian background also had either a personal or family history of autoimmune disease. Distressing vitiligo, initially in an acrofacial distribution, developed unexpectedly in these four patients, before then progressing to involve other parts of the body. Potential factors in the appearance of vitiligo in this setting, including nitisinone and other drug therapy, are explored and responses to the appearance of vitiligo are discussed.
Published: 2021

48. Delaying surgery for patients with a previous SARS-CoV-2 infection

Author: James, C Glasbey, Dmitri, Nepogodiev, Omar, Omar, Joana Ff Simoes, Adesoji, Ademuyiwa, Marco, Fiore, Ana, Minaya-Bravo, Richard, Shaw, Raghavan, Vidya, Aneel, A Bhangu, Kwabena, Siaw-Acheampong, Ruth, A Benson, Edward, Bywater, Daoud, Chaudhry, Brett, E Dawson, Jonathan, P Evans, Rohan, R Gujjuri, Emily, Heritage, Conor, S Jones, Sivesh, K Kamarajah, Chetan, Khatri, Rachel, A Khaw, James, M Keatley, Andrew, Knight, Samuel, Lawday, Elizabeth, Li, Harvinder, S Mann, Ella, J Marson, Kenneth, A McLean, Siobhan, C Mckay, Emily, C Mills, Gianluca, Pellino, Maria, Picciochi, Elliott, H Taylor, Abhinav, Tiwari, Isobel, M Trout, Mary, L Venn, Richard Jw Wilkin, Aneel, Bhangu, Neil, J Smart, Susan, Moug, Dale, Vimalchandran, Abigail, Vallance, Peter, Pockney, Ewen, A Griffiths, Richard Pt Evans, Philip, Townend, Keith, Roberts, Siobhan, Mckay, John, Isaac, Sohei, Satoi, John, Edwards, Aman, S Coonar, Adrian, Marchbank, Edward, J Caruana, Georgia, R Layton, Akshay, Patel, Alessandro, Brunelli, Samuel, Ford, Anant, Desai, Alessandro, Gronchi, Max, Almond, Fabio, Tirotta, Sinziana, Dumitra, Angelos, Kolias, Stephen, J Price, Daniel, M Fountain, Michael, D Jenkinson, Peter, Hutchinson, Hani, J Marcus, Rory, J Piper, Laura, Lippa, Franco, Servadei, Ignatius, Esene, Christian, Freyschlag, Iuri, Neville, Gail, Rosseau, Karl, Schaller, Andreas, K Demetriades, Faith, Robertson, Alex, Alamri, Andrew, G Schache, Stuart, C Winter, Michael, Ho, Paul, Nankivell, Juan Rey Biel, Martin, Batstone, Ian, Ganly, Alex, Wilkins, Jagdeep, K Singh, Dinesh, Thekinkattil, Sudha, Sundar, Christina, Fotopoulou, Elaine, Leung, Tabassum, Khan, Luis, Chiva, Jalid, Sehouli, Anna, Fagotti, Paul, Cohen, Murat, Gutelkin, Rahel, Ghebre, Thomas, Konney, Rene, Pareja, Rob, Bristow, Sean, Dowdy, Shylasree Ts Rajkumar, Joe, Ng, Keiiji, Fujiwara, Grant, D Stewart, Benjamin, Lamb, Krishna, Narahari, Alan, Mcneill, Alexandra, Colquhoun, John, Mcgrath, Steve, Bromage, Ravi, Barod, Veeru, Kasivisvanathan, Tobias, Klatte, Tom Ef Abbott, Michel, Adamina, Adesoji, O Ademuyiwa, Arnav, Agarwal, Ehab, Alameer, Derek, Alderson, Felix, Alakaloko, Markus, Albertsmeiers, Osaid, Alser, Muhammad, Alshaar, Sattar, Alshryda, Alexis, P Arnaud, Knut Magne Augestad, Faris, Ayasra, José, Azevedo, Brittany, K Bankhead-Kendall, Emma, Barlow, Ruth, Blanco-Colino, Amanpreet, Brar, Kerry, A Breen, Chris, Bretherton, Igor Lima Buarque, Joshua, Burke, Mohammad, Chaar, Sohini, Chakrabortee, Peter, Christensen, Daniel, Cox, Moises, Cukier, Miguel, F Cunha, Giana, H Davidson, Salomone Di Saverio, Thomas, M Drake, John, G Edwards, Muhammed, Elhadi, Sameh, Emile, Shebani, Farik, J Edward Fitzgerald, Tatiana, Garmanova, Gaetano, Gallo, Dhruv, Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo, Grecinos, Madalegna, Gründl, Constantine, Halkias, Ewen, M Harrison, Intisar, Hisham, Peter, J Hutchinson, Shelley, Hwang, Arda, Isik, Pascal, Jonker, Haytham Ma Kaafarani, Schelto, Kruijff, Ismail, Lawani, Hans, Lederhuber, Sezai, Leventoglu, Andrey, Litvin, Andrew, Loehrer, Markus, W Löffler, Maria Aguilera Lorena, Maria Marta Madolo, Piotr, Major, Janet, Martin, Hassan, N Mashbari, Dennis, Mazingi, Symeon, Metallidis, Helen, M Mohan, Rachel, Moore, David, Moszkowicz, Joshua, S Ng-Kamstra, Mayaba, Maimbo, Milagros, Niquen, Faustin, Ntirenganya, Maricarmen, Olivos, Kacimi, Oussama, Oumaima, Outani, Marie Dione Parreno-Sacdalanm, Francesco, Pata, Carlos Jose Perez Rivera, Thomas, D Pinkney, Willemijn van der Plas, Ahmad, Qureshi, Dejan, Radenkovic, Antonio Ramos-De la Medina, April, C Roslani, Martin, Rutegård, Irène, Santos, Raza, Sayyed, Andrew, Schache, Andreas, A Schnitzbauer, Justina, O Seyi-Olajide, Neil, Sharma, Sebastian, Shu, Kjetil, Soreide, Antonino, Spinelli, Malin, Sund, Stephen, Tabiri, Georgios, Tsoulfas, Gabrielle, H van Ramshorst, Dale, Vimalachandran, Oliver, J Warren, Duane, Wedderburn, Naomi, Wright, Eurosurg, Allemand, C, Boccalatte, L, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Alurralde, C, L Caram, E, Eskinazi, D, P Mendoza, J, Usandivaras, M, Badra, R, Esteban, A, S García, J, M García, P, I Gerchunoff, J, M Lucchini, S, Nigra, Ma, Vargas, L, Hovhannisyan, T, Stepanyan, A, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, Mclaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, H Ahn, J, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, G, Ye, Zhang, H, Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, G Vo, U, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, H Lam, Y, S Ong, B, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, D, Ho, Jeyarajan, E, Jordan, S, Lim, A, J Nolan, G, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, M Von Papen, Wullschleger, M, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, R Guerra, G, Bolt, J, Buddingh, K, N Dudi-Venkata, N, Jog, S, M Kroon, H, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, Mcgahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, W Hii, M, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Wright, G, Lanner, M, Königsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Öfner, D, Tsibulak, I, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Öhlberger, L, Presl, J, Wimmer, A, Namazov, İ, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, S St John, Walkes, K, Flamey, N, Pattyn, P, Oosterlinck, W, J Van den Eynde, R Van den Eynde, Gatti, A, Nardi, C, Oliva, R, R De Cicco, Cecconello, I, Gregorio, P, L Pontual Lima, U Ribeiro Junior, Takeda, F, M Terra, R, Sokolov, M, Kidane, B, Srinathan, S, Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Dumitra, S, Kouyoumdjian, A, Johnston, B, Russell, C, Demyttenaere, S, Garfinkle, R, Abou-Khalil, J, Nessim, C, Stevenson, J, Heredia, F, Almeciga, A, Fletcher, A, Merchan, A, O Puentes, L, J Mendoza Quevedo, Bačić, G, Karlović, D, Kršul, D, Zelić, M, Luksic, I, Mamic, M, Bakmaz, B, Ćoza, I, Dijan, E, Katusic, Z, Mihanovic, J, Rakvin, I, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Szubota, I, Žatecký, J, Javurkova, V, Klat, J, Avlund, T, Christensen, P, L Harbjerg, J, H Iversen, L, W Kjaer, D, Ø Kristensen, H, Mekhael, M, L Ebbehøj, A, Krarup, P, Schlesinger, N, Smith, H, Abdelsamed, A, Y Azzam, A, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, E Abosamak, N, M Al Sayed, Ashoush, F, Atta, R, Elazzazy, E, Elhoseiny, M, Elnemr, M, S Elqasabi, M, E Elsayed Hewalla, M, Elsherbini, I, Essam, E, Eweda, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, S Qatora, M, Ragab, M, Sabry, A, Saifeldin, H, M Saleh Mesbah Mohamed Elkaffas, Samih, A, A Samir Abdelaal, Shehata, S, Shenit, K, Attia, D, Kamal, N, Osman, N, M Abbas, A, Abd Elazeem Has, M Abdelkarem, M, Alaa, S, K Ali, A, Ayman, A, G Azizeldine, M, Elkhayat, H, Melghazaly, S, A Monib, F, A Nageh, M, M Saad, M, Salah, M, Shahine, M, A Yousof, E, Youssef, A, Eldaly, A, Elfiky, M, Nabil, A, Amira, G, Sallam, I, Sherief, M, Sherif, A, Abdelrahman, A, Aboulkassem, H, Ghaly, G, Hamdy, R, Morsi, A, Sherif, G, Abdeldayem, H, I Abdelkader Salama, Balabel, M, Fayed, Y, E Sherif, A, Bekele, D, Kauppila, J, Sarjanoja, E, Helminen, O, Huhta, H, H Kauppila, J, Beyrne, C, Jouffret, L, Lugans, L, Marie-Macron, L, Chouillard, E, B De Simone, Bettoni, J, Dakpé, S, Devauchelle, B, Lavagen, N, Testelin, S, Boucher, S, Breheret, R, Gueutier, A, Kahn, A, Kün-Darbois, J, Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P, Chebaro, A, Drubay, V, Elamrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, R Pruvot, F, Truant, S, Zerbib, P, Ballouhey, Q, Barrat, B, Laloze, J, Salle, H, Taibi, A, Usseglio, J, Bergeat, D, Merdrignac, A, B Le Roy, O Perotto, L, Scalabre, A, Aimé, A, Ezanno, A, Malgras, B, Bouche, P, Tzedakis, S, Cotte, E, Glehen, O, Lifante, J, D'Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B, Bardet, J, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Moumen, A, Pourcher, G, Seguin-Givelet, A, Tribillon, E, Duchalais, E, Espitalier, F, Ferron, C, Malard, O, Bork, U, Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P, Beyer, K, Kamphues, C, Lauscher, J, N Loch, F, Schineis, C, Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J, Becker, R, Jonescheit, J, Pergolini, I, Reim, D, Boeker, C, Hakami, I, Mall, J, Liokatis, P, Smolka, W, Nowak, K, Reinhard, T, Hölzle, F, Modabber, A, Winnand, P, Knitschke, M, Kauffmann, P, Wolfer, S, Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R, Bertolani, E, Königsrainer, A, W Löffler, M, Quante, M, Steidle, C, Überrück, L, Yurttas, C, S Betz, C, Bewarder, J, Böttcher, A, Burg, S, Busch, C, Gosau, M, Heuer, A, Izbicki, J, O Klatte, T, Koenig, D, Moeckelmann, N, Nitschke, C, Priemel, M, Smeets, R, Speth, U, Thole, S, G Uzunoglu, F, Vollkommer, T, Zeller, N, J Battista, M, Gillen, K, Hasenburg, A, Krajnak, S, Linz, V, Schwab, R, Angelou, K, Haidopoulos, D, Rodolakis, A, Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A, I Antonopoulou, M, K Manatakis, D, Tasis, N, Arkadopoulos, N, Danias, N, Economopoulou, P, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Selmani, J, Sidiropoulos, T, Tsaousis, V, Vassiliu, P, Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G, Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Koukoulis, G, M Ntziovara, A, Petropoulos, K, Soulikia, K, Tsiamalou, I, Zervas, K, Zourntou, S, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D, Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G, Karaitianos, I, Tsirlis, T, Charalabopoulos, A, Liakakos, T, Mpaili, E, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Anthoulakis, C, Christou, C, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D, Athanasakis, E, Chrysos, E, Tsiaousis, J, Xenaki, S, Xynos, E, Futaba, K, F Ho, M, F Hon, S, Mak, Twc, Ssm, Ng, C Foo, C, Banky, B, Suszták, N, Aremu, M, Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L, Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Killeen, S, Lynch, N, Mccarthy, A, Mustafa, H, O'Brien, S, O'Leary, P, Syed, Was, Vernon, L, Callanan, D, Huang, L, Ionescu, A, Sheahan, P, Balasubramanian, I, Boland, M, Conlon, K, Evoy, D, Fearon, N, Gallagher, T, Geraghty, J, Heneghan, H, Kennedy, N, Maguire, D, Mccartan, D, W McDermott, E, S Prichard, R, Winter, D, Alazawi, D, Barry, C, Boyle, T, Butt, W, M Connolly, E, Donlon, N, Donohue, C, A Fahey, B, Farrell, R, Fitzgerald, C, Kinsella, J, O Larkin, J, Lennon, P, J Maguire, P, Mccormick, P, J Mehigan, B, Mohan, H, Nugent, T, O'Sullivan, H, Ravi, N, V Reynolds, J, Rogers, A, Shokuhi, P, Smith, J, A Smith, L, Timon, C, Bashir, Y, Bass, G, Connelly, T, Earley, H, A Elliott, J, Gillis, A, Kavanagh, D, Neary, P, O'Riordan, J, S Reynolds, I, Rice, D, Ridgway, P, Umair, M, Whelan, M, Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, A, Hogan, A, Kerin, M, Lowery, A, Mcanena, P, Mkkevitt, K, Nizami, K, Ryan, É, Samy, A, C Coffey, J, Cunningham, R, Devine, M, Nally, D, Peirce, C, Tormey, S, Hardy, N, O'Malley, S, Ryan, M, Macina, S, M Mariani, N, Opocher, E, A Pisani Ceretti, Ferrari, F, Odicino, F, Sartori, E, Cotsoglou, C, Granieri, S, Bianco, F, Camillo, A, Colledan, M, Tornese, S, F Zambelli, M, Bissolotti, G, Fusetti, S, Lemma, F, Marino, M, Mirabella, A, Vaccarella, G, Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, R De Vincenti, A Di Bella, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, N Ringressi, M, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R, Bassi, C, Campagnaro, T, Casetti, L, M De Pastena, Esposito, A, Fontana, M, Guglielmi, A, Landoni, L, Malleo, G, Marchegiani, G, Nobile, S, Paiella, S, Pedrazzani, C, Rattizzato, S, Ruzzenente, A, Salvia, R, Turri, G, Tuveri, M, Bellora, P, D'Aloisio, G, Ferrari, M, Francone, E, Gentilli, S, Nikaj, H, Bianchini, M, Chiarugi, M, Coccolini, F, G Di Franco, Furbetta, N, Gianardi, D, Guadagni, S, Morelli, L, Palmeri, M, Tartaglia, D, Anania, G, Carcoforo, P, Chiozza, M, A De Troia, M Koleva Radica, Portinari, M, G Sibilla, M, Urbani, A, Fabbri, N, V Feo, C, Gennari, S, Parini, S, Righini, E, Ampollini, L, Bellanti, L, Bergonzani, M, Bertoli, G, Bocchialini, G, D'Angelo, G, Lanfranco, D, Musini, L, Poli, T, P Santoro, G, Varazzani, A, Aguzzoli, L, Borgonovo, G, C Castro Ruiz, Coiro, S, Falco, G, D Mandato, V, Mastrofilippo, V, T Montella, M, Annessi, V, Zizzo, M, Grossi, U, Novello, S, Romano, M, Rossi, S, Zanus, G, Esposito, G, Frongia, F, Pisanu, A, Podda, M, Belluco, C, Lauretta, A, Montori, G, Moras, L, Olivieri, M, Bussu, F, G Carta, A, L Cossu, M, Cottu, P, Fancellu, A, F Feo, C, C Ginesu, G, Giuliani, G, Madonia, M, Perra, T, Piras, A, Porcu, A, Rizzo, D, M Scanu, A, Tedde, A, Tedde, M, Delrio, P, Rega, D, Badalamenti, G, Campisi, G, Cordova, A, Franza, M, Maniaci, G, Rinaldi, G, Toia, F, Calabrò, M, Farnesi, F, G Lunghi, E, Muratore, A, S Pipitone Federico, N, Bàmbina, F, D'Andrea, G, Familiari, P, Picotti, V, G De Palma, Luglio, G, Pagano, G, P Tropeano, F, Baldari, L, A Beltramini, G, Boni, L, Cassinotti, E, Gianni, A, Pignataro, L, Torretta, S, Abatini, C, Baia, M, Biasoni, D, Bogani, G, Cadenelli, P, Capizzi, V, Cioffi, Spb, Citterio, D, V Comini, L, Cosimelli, M, Fiore, M, Folli, S, Gennaro, M, Giannini, L, Gronchi, A, Guaglio, M, Macchi, A, Martinelli, F, Mazzaferro, V, Mosca, A, Pasquali, S, Piazza, C, Raspagliesi, F, Rolli, L, Salvioni, R, Sarpietro, G, Sarre, C, Sorrentino, L, Agnes, A, Alfieri, S, Belia, F, Biondi, A, Cozza, V, D'Amore, A, D'Ugo, D, V De Simone, Fagotti, A, Gasparini, G, Gordini, L, Litta, F, P Lombardi, C, Lorenzon, L, A Marra, A, Marzi, F, Moro, A, Parello, A, Perrone, E, Persiani, R, Ratto, C, Rosa, F, Saponaro, G, Scambia, G, Scrima, O, Sganga, G, Tudisco, R, Belli, A, Granata, V, Izzo, F, Palaia, R, Patrone, R, M Carrano, F, M Carvello, M, A De Virgilio, F Di Candido, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spinelli, A, Spriano, G, M Donati, D, Frisoni, T, Palmerini, E, Aprile, A, Barra, F, Batistotti, P, Ferrero, S, Fregatti, P, Scabini, S, Sparavigna, M, Asti, E, Bernardi, D, Bonavina, L, Lovece, A, Adamoli, L, Ansarin, M, Cenciarelli, S, Chu, F, R De Berardinis, U Fumagalli Romario, Mastrilli, F, Pietrobon, G, Tagliabue, M, Badellino, E, Ferrero, A, Massobrio, R, A De Manzoni Garberini, Federico, P, Maida, P, Marra, E, Marte, G, Petrillo, A, Tammaro, T, Tufo, A, Berselli, M, Borroni, G, Cocozza, E, Conti, L, Desio, M, Livraghi, L, Quintodei, V, Rizzi, A, Zullo, A, Baldi, C, Corbellini, C, M Sampietro, G, Cellerino, P, Baldini, E, Capelli, P, M Isolani, S, Ribolla, M, Bondurri, A, Colombo, F, Ferrario, L, Guerci, C, Maffioli, A, Armao, T, Ballabio, M, Bisagni, P, Gagliano, A, Longhi, M, Madonini, M, Pizzini, P, M Baietti, A, 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Cadenelli P., Capizzi V., Spb C., Citterio D., Comini L.V., Cosimelli M., Folli S., Gennaro M., Giannini L., Guaglio M., Macchi A., Martinelli F., Mazzaferro V., Mosca A., Pasquali S., Piazza C., Raspagliesi F., Rolli L., Salvioni R., Sarpietro G., Sarre C., Sorrentino L., Agnes A., Alfieri S., Belia F., Biondi A., Cozza V., De Simone V., Gasparini G., Gordini L., Litta F., Lombardi C.P., Lorenzon L., Marra A.A., Marzi F., Moro A., Parello A., Perrone E., Persiani R., Ratto C., Rosa F., Saponaro G., Scambia G., Scrima O., Sganga G., Tudisco R., Belli A., Granata V., Izzo F., Palaia R., Patrone R., Carrano F.M., De Virgilio A., Di Candido F., Ferreli F., Gaino F., Mercante G., Rossi V., Emanuele P., Frisoni T., Palmerini E., Aprile A., Barra F., Batistotti P., Ferrero S., Fregatti P., Scabini S., Sparavigna M., Asti E., Bernardi D., Bonavina L., Lovece A., Adamoli L., Ansarin M., Cenciarelli S., Chu F., De Berardinis R., Fumagalli Romario U., Mastrilli F., Pietrobon G., Tagliabue M., Badellino E., Ferrero A., Massobrio R., De Manzoni Garberini A., Federico P., Maida P., Marra E., Marte G., Petrillo A., Tammaro T., Tufo A., Berselli M., Borroni G., Cocozza E., Conti L., Desio M., Livraghi L., Quintodei V., Rizzi A., Zullo A., Baldi C., Corbellini C., Sampietro G.M., Cellerino P., Baldini E., Capelli P., Isolani S.M., Ribolla M., Bondurri A., Colombo F., Ferrario L., Guerci C., Maffioli A., Armao T., Ballabio M., Bisagni P., Gagliano A., Longhi M., Madonini M., Pizzini P., Baietti A.M., Biasini M., Maremonti P., Neri F., Prucher G.M., Ricci S., Ruggiero F., Zarabini A.G., Barmasse R., Mochet S., Usai A., Incollingo P., Mancini S., Marino Cosentino L., Sagnotta A., Fruscio R., Grassi T., Nespoli L.C., Tamini N., Anastasi A., Bartalucci B., Bellacci A., Canonico G., Capezzuoli L., Di Martino C., Ipponi P., Linari C., Montelatici M., Nelli T., Spagni G., Tirloni L., Vitali A., Abate E., Casati M., Casiraghi T., Laface L., Schiavo M., Arminio A., Cotoia A., Lizzi V., 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Kerawala A.A., Memon A.S., Nafees Ahmed R., Rai L., Ayub B., Hassan N., Martins R.S., Ramesh P., Butt U., Kashif M., Khan W.H., Umar M., Waris Farooka M., Wasim T., Ayubi A., Rashid I., Waqar S.H., Falcon G.M., Robles R., Jocson R., Teh C., Bobinski M., Kotarski J., Rasoul-Pelinska K., Azevedo C., Machado D., Mendes F., De Sousa X., Fernandes U., Ferreira C., Guidi G., Leal C., Marcal A., Marques R., Martins D., Melo A., Tenreiro N., Vaz Pereira R., Vieira B., Almeida J.I., Correia de Sa T., Mjma C., Fernandes V., Ferraz I., Gil C.G., Lima da Silva C., Lopes L., Machado N., Marialva J., Nunes Coelho M., Pedro J., Pereira C., Reis R., Ribeiro A., Santos R., Saraiva P., Silva R., Tavares F., Teixeira M., Almeida A.C., Amaral M.J., Andrade R., Athayde Nemesio R., Breda D., Camacho C., Canhoto C., Colino M., Correia S., Costa M., De Barros J., De Oliveira Lopez A.L., Duque M., Garrido S., Guerreiro P., Guimaraes A., Lazaro A., Lopes C., Martins R., Nogueira O., Oliveira A., Oliveira J.M., Rodrigues M., Ruivo A., Santos E., Silva M., Simoes J., Valente da Costa A., Almeida A., Cavaleiro S., Devezas V., Faria C.S., Jacome F., Magalhaes Maia M., Nogueiro J., Pereira A., Pereira-Neves A., Pina-Vaz T., Santos-Sousa H., Silveira H., Vaz S., Vieira P., Gomes da Costa A., Tojal A., Cardoso N., Cardoso P., Domingues J.C., Henriques P., Manso M.I., Martins dos Santos G., Morais H., Pereira R., Revez T., Ribeiro R., Ribeiro V.I., Soares A., Sousa S., Teixeira J., Amorim E., Baptista V.H., Dias B., Fazenda A., Melo Neves J.P., Policarpo F., Veiga D., Bandovas J.P., Borges N., Branquinho A., Chumbinho B., Correia J., Fidalgo H., Figueiredo de Barros I., Frade S., Gomes J., Maciel J., Pina S., Silva N., Silveira Nunes I., Sousa R., Ascensao J., Azevedo P., Costeira B., Cunha C., Garrido R., Gomes H., Lourenco I., Mendinhos G., Miranda P., Peralta Ferreira M., Ribeiro J., Rio Rodrigues L., Sousa Fernandes M., Galvao D., Soares A.C., Vieira A., Patricio B., Pmdd S., Vieira Paiva Lopes A.C., Cunha R., Faustino A., Freitas A., Mendes J.R., Parreira R., Rosa J., Teves M., Abreu da Silva A., Claro M., Costa Santos D., Deus A.C., Grilo J.V., Borges F., Corte Real J., Henriques S., Lima M.J., Matos Costa P., Brito da Silva F., Caiado A., Fonseca F., Angelo M., Baiao J.M., Martins Jordao D., Vieira Caroco T., Messias J., Millan A., Salgado I., Santos P., Baia C., Canotilho R., Correia A.M., Peyroteo M., Videira J.F., Escobar P., Maldonado Santiago M., Kassir R., Sauvat F., Bezede C., Chitul A., Ciofic E., Cristian D., Grama F., Pirtea L., Secosan C., Bonci E., Gata V., Titu S., Ginghina O., Iordache N., Iosifescu R.V., Kazachenko E., Markaryan D., Rodimov S., Tsarkov P., Tulina I., Litvina Y., Provozina A., Agapov M., Galliamov E., Kakotkin V., Kubyshkin V., Камалов А., Alshahrani M., Alsharif F., Eskander M., Al Raddadi R., Majrashi S., Mashat A., Akeel N., Alharthi M., Aljiffry M., Basendowah M., Farsi A., Ghunaim M., Khoja A., Maghrabi A., Malibary N., Nassif M., Nawawi A., Saleem A., Samkari A., Trabulsi N., Al Awwad S., Alghamdi M., Alnumani T., Nasser M., Alhefdhi A., Almalik O., Alomair A., Alotaibi N., Alresaini F., Alsalamah R., Alsobhi S., Mahasin Z., Othman E., Velagapudi S., Al Habes H., Alkarak S., Alqannas M., Alyami M., Alzamanan M., Cortes Guiral D., Elawad A., Alriyees L., Alselaim N., Abdulkareem A., Ajlan A., Akkour K., Al-Habib A., Al-Khayal K., Alatar A., Alburakan A., Alhalal H., Alhassan B., Alhassan N., Alobeed O., Alsaif A., Alsaif F., Alshammari S., Alshaygy I., Barry M., Bin Nasser A., Bin Traiki T., Bokhari A., Elwatidy S., Helmi H., Madkhali A., Nouh T., Rabah P.D., Zubaidi A., Paunovic I., Slijepcevic N., Aleksic L., Antic A., Barisic G., Ceranic M., Galun D., Grubac Z., Jelenkovic J., Kecmanovic D., Kmezic S., Knezevic D., Krivokapic Z., Latincic S., Markovic V., Matic S., Miladinov M., Pavlov M., Pejovic I., Tadic B., Vasljevic J., Velickovic D., Zivanovic M., Perovic M., Srbinovic L., Andrijasevic S., Bozanovic T., Cerovic Popovic R., Dokic M., Janjic T., Jeremic K., Kadija S., Ladjevic Likic I., Mirkovic L., Pantovic S., Pilic I., Radojevic M., Stefanovic A., Vidakovic S., Vilendecic Z., Antic S., Dunderovic D., Jelovac D., Jezdic Z., Konstantinovic V., Kotlar B., Kuzmanovic C., Lazic M., Petrovic M., Popovic F., Pucar A., Romic M., Sumrak S., Vujanac V., Bascarevic V., Bogdanovic I., Grujicic D., Ilic R., Milicevic M., Milisavljevic F., Miljkovic A., Paunovic A., Scepanovic V., Stanimirovic A., Todorovic M., Jotic A., Milovanovic J., Trivic A., Bumbasirevic U., Dzamic Z., Kajmakovic B., Prijovic N., Zivkovic M., Buta M., Cvetkovic A., Djurisic I., Gacic S., Goran M., Inic Z., Jeftic N., Jevric M., Jokic V., Markovic I., Milanovic M., Nikolic S., Pejnovic L., Savkovic N., Spurnic I., Stevic D., Stojiljkovic D., Vucic N., Zegarac M., Karamarkovic A., Kenic M., Kovacevic B., Krdzic I., Milutinovic V., Chan C.W., Lieske B., Galis B., Simko K., Almgla N., Bernon M., Boutall A., Cairncross L., Herman A., Hilton T., Jonas E., Kloppers C., Malherbe F., Mugla W., Nel D., Rayamajhi S., Van Wyngaard T., Vogel J., Castano-Leon A.M., Delgado Fernandez J., Eiriz Fernandez C., Espino Segura-Illa M., Esteban Sinovas O., Garcia Perez D., Gomez P., Jimenez-Roldan L., Lagares A., Moreno-Gomez L., Paredes I., Perez Nunez A., Sanchez Aniceto G., Santas M., Fernandez Rodriguez P., Paniagua Garcia Senorans M., Sanchez-Santos R., Vigorita V., Acrich E., Baena Sanfeliu E., Barrios O., Golda T., Santanach C., Serrano-Navidad M., Sorribas Grifell M., Vives R.V., Escola D., Jimenez A., Cayetano Paniagua L., Gomez Fernandez L., Artigues E., Bernal-Sprekelsen J.C., Catala Bauset J.C., Collera P., Diaz Del Gobbo R., Farre Font R., Flores Clotet R., Gomez Diaz C.J., Guardia N., Guariglia C.A., Osorio A., Sanchez Jimenez R., Sanchon L., Soto Montesinos C., Albi Martin B., Garcia Villayzan J.E., Alonso-Lamberti L., Assaf M., Baeza Pintado N., Carabias A., Garcia-Quijada J., Jimenez Miramon J., Jimenez V., 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Perez-Saborido B., Sanchez Gonzalez J., Alconchel F., Conesa A., Gil Martinez J., Gutierrez Fernandez A.I., Lopez Abad A., Nicolas-Lopez T., Ramirez Romero P., Roca Calvo M.J., Rodrigues K., Ruiz Manzanera J.J., Soriano A.I., Cano A., Capitan-Morales L., Cintas Catena J., Gomez-Rosado J., Oliva Mompean F., Rio Lafuente F.D., Torres Arcos C., Valdes-Hernandez J., Cholewa H., Domingo S., Frasson M., Lago V., Marina Martin T., Martinez Chicote C., Sancho-Muriel J., Landaluce-olavarria A., Lecumberri D., Abad Gurumeta A., Abad-Motos A., Martinez-Hurtado E., Ripolles-Melchor J., Ruiz Escobar A., Cuadrado-Garcia A., Garcia-Sancho Tellez L., Heras Aznar J., Mate P., Ortega Vazquez I., Picardo A.L., Rojo Lopez J.A., Sanchez Cabezudo Noguera F., Serralta de Colsa D., Anchuelo Latorre J., Cagigas Fernandez C., Caina Ruiz R., Gomez Ruiz M., Hernanz F., Jimeno Fraile J., Martinez-Perez P., Poch C., Santarrufina Martinez S., Valbuena Jabares V., Moliner-Sanchez C., Pingarron-Martin L., Rey-Biel J., Ruiz Martin I., Blas Laina J.L., Cros B., Escartin J., Garcia Egea J., Nogues A., Talal El-Abur I., Yanez C., Cagigal Ortega E.P., Cervera I., Diaz Pena P., Gdcr E., Enjuto D., Fernandez Bernabe P., Garces Garcia R., Gonzalez J., Hernandez I., Herrera-Merino N., Marqueta De Salas M., Martinez Pascual P., Perez Gonzalez M., Ramos Bonilla A., Rodriguez Gomez L., Bescos C., Brana I., Caimari B., De Pablo Garcia-Cuenca A., Duran-Valles F., Espin-Basany E., Giralt Lopez de Sagredo J., Pamias J., Prat N., Pujol Pina R., Arulanantham A., Gbk B., Jayarajah U., Ravindrakumar S., Rodrigo V.S., Srishankar S., Elbe P., Lindqvist E.K., Taflin H., Alga A., Heinius G., Nordberg M., Pieniowski E., Gkekas I., Lofgren N., Arigoni M., Bernasconi M., Christoforidis D., Di Giuseppe M., La Regina D., Mongelli F., Chevallay M., Dwidar O., Gialamas E., Sauvain M., Klenke F., Kollar A., Kurze C., Bachler T., Crugnale A.S., Giardini M., Guglielmetti L., Peros G., Solimene F., Aghayeva A., Hamzaoglu I., Sahin I., Akaydin E., Aliyeva Z., Aytac E., Baca B., Dulgeroglu O., Ozben V., Ozmen B.B., Uras C., Arikan A.E., Bilgin I.A., Bozkirli B., Ceyhan G.O., Kara H., Karahasanoglu T., Celik H., Akilli H., Ayhan A., Kuscu E., Akgor U., Dincer H.A., Erol T., Gultekin M., Orhan N., Ozgul N., Salman M.C., Soyak B., Alhamed A., Ergun S., OZcelik M.F., Sanli A.N., Uludag S.S., Velidedeoglu M., Zengin A.K., Kara Y., Kocatas A., Cimenoglu B., Demirhan R., Saracoglu K., Azamat I.F., Balik E., Bugra D., Giray B., Kulle C.B., Taskiran C., Vatansever D., Gozal K., Guler S.A., Koken H., Tatar O.C., Utkan N.Z., Yildirim A., Yuksel E., Akin E., Altintoprak F., Bayhan Z., Cakmak G., Capoglu R., Celebi F., Demir H., Dikicier E., Firat N., Gonullu E., Kocer B., Kucuk I.F., Mantoglu B., Colak E., Kucuk G.O., Goksoy B., Bozkurt E., Citgez B., Mihmanli M., Tanal M., Yetkin G., Akalin M., Arican C., Avci E.K., Aydin C., Demirli Atici S., Emiroglu M., Kaya T., Kebabci E., Kilinc G., Kirmizi Y., Ogucu H., Salimoglu S., Sert I., Tugmen C., Tuncer K., Uslu G., Yesilyurt D., Karaman E., Kolusari A., Yildiz A., Benson O., Lule H., Agilinko J., Ahmeidat A., Barabasz M., Bekheit M., Cheung L.K., Colloc T., Cymes W., Elhusseini M., Gradinariu G., Hannah A., Mignot G., Shaikh S., Sharma P., Abu-Nayla I., Agrawal A., Al-Mohammad A., Ali S., Ashcroft J., Azizi A., Baker O., Balakrishnan A., Byrne M., Cotter A., Coughlin P., Davies R.J., Durrani A., Elshaer M., Fordington S., Forouhi P., Georgiades F., Grimes H., Habeeb A., Hudson V., Irune E., Jah A., Khan D.Z., Kyriacou H., Liau S., Luke L., Mahmoud R., Mannion R., Masterson L., Mitrofan C.G., Mohan M., Morris A., Murphy S., O'Neill R., Price S., Pushpa-rajah J., Raby-Smith W., Ramzi J., Rooney S., Santarius T., Singh A., Tan X.S., Townson A., Tweedle E., Walker C., Waseem S., Yordanov S., Jones T., Kattakayam A., Loh C., Lunevicius R., Pringle S., Sheel A., Rossborough C., Angelou D., Choynowski M., Neely D., Tutoveanu G., Ahad S., Mfi D.L.C.M., Mosley F., Oktseloglou V., Alanbuki A., Patel M., Shabana A., Perera E., Raveendran D., Ravi-Shankar K., Thiruchelvam J., Arrowsmith L., Campbell W., Grove T., Kontovounisios C., Warren O., Rolland P., Aggarwal A., Brown S., Jelley C., Neal N., Clifford R., Eardley N., Krishnan E., Manu N., Martin E., Roy Mahapatra S., Serevina O.L., Smith C., Bordenave M., Houston R., Putnam G., Robson A., Tustin H., Emslie K., Labib P.L., Miller D., Minto G., Natale J., Nwinee H., Panahi P., Rogers L., Abubakar A., Kyk K., O'Brien H., Sasapu K., Woodun H., Inglis R., Ng H.J., De Gea Rico A., Ghazali N., Lambert J., Markose G., Math S., Sarantitis I., Shrestha D., Sultana A., Taggarsi M., Timbrell S., Vaz O.P., Vitone L., Day A., Dent H., Fahim M., Waheed S., Hunt A., Laskar N., Gupta A., Steinke J., Thrumurthy S., Massie E., Rutherford D., Wilson M., Hardie J., Kazzaz S., Handa S., Kaushal M., Kler A., Patel P., Redfern J., Tezas S., Aawsaj Y., Amonkar S., Blackwell L., Blake D., Carter J., Emerson H., Fisher A., Katory M., Korompelis P., Mustafa A., Pearce L., Ratnavelu N., Reehal R., Kretzmer L., Lalou L., Manku B., Parwaiz I., Stafford J., Abdelkarim M., Asqalan A., Gala T., Ibrahim S., Maw A., Mithany R., Morgan R., Sundaram Venkatesan G., Ang K., Chowdhry M.F., Mohammad A., Nakas A., Rathinam S., Boal M., Brown O., Dwerryhouse S., Higgs S., Boyd E., Irvine V., Kirk A., Bakolas G., Boulton A., Chandock A., Kumar M., Agoston P., Bille A., Challacombe B., Fraser S., Harrison-Phipps K., King J., Mehra G., Mills L., Najdy M., Nath R., Okiror L., Pilling J., Rizzo V., Routledge T., Sayasneh A., Stroman L., Wali A., Fehervari M., Habib N., Hamrang-Yousefi S., Jawad Z., Jiao L., Pai M., Ploski J., Rajagopal P., Saso S., Sodergren M., Spalding D., Laws S., Hardie C., Alam R., Budacan A., Cahill J., Kalkat M., Karandikar S., Kenyon L., Naumann D., Ayorinde J., Chase T., Cuming T., Ghanbari A., Humphreys L., Tayeh S., Aboelkassem Ibrahim A., Bichoo R., Cao H., Akw C., Choudhury J., Evans C., Fitzjohn H., Ikram H., Langstroth M., Loubani M., Nazir S., Ssa Q., Robinson A., Ross E., Sehgal T., Dixon J., Dunning J., Freystaetter K., Jha M., Lester S., Madhavan A., Thulasiraman S.V., Viswanath Y., Curl-Roper T., Delimpalta C., Ccl L., Velchuru V., Westwood E., Belcher E., Bond-Smith G., Chidambaram S., Di Chiara F., Fasanmade K., Fraser L., Fu H., Ganau M., Gore S., Graystone J., Jeyaretna D., Khatkar H., Lami M., Maher M., Mastoridis S., Mihai R., Piper R., Prabhu S., Obf R., Selbong U., Shah K., Smillie R., Sravanam S., Stavroulias D., Tebala G.D., Vatish M., Verberne C., Wallwork K., Winter S., Bhatti M.I., Boyd-Carson H., Elsey E., Gemmill E., Herrod P., Jibreel M., Lenzi E., Saafan T., Sapre D., Sian T., Watson N., Athanasiou A., Bourke G., Bradshaw L., Burke J., Coe P., Costigan F., Elkadi H., Johnstone J., Kanatas A., Kantola V., Kaufmann A., Laios A., Lam S., Munot S., Nahm C., Otify M., Pompili C., Smith I., Theophilou G., Toogood G., Wade R., Ward D., West C., Annamalai S., Ashmore C., Boddy A., Hossain T., Kourdouli A., Gvaramadze A., Jibril A., Prusty L., Thekkinkattil D., Harky A., Shackcloth M., Askari A., Cirocchi N., Kudchadkar S., Patel K., Sagar J., Shaw S., Talwar R., Abdalla M., Edmondson R., Ismail O., Jones D., Newton K., Stylianides N., Aderombi A., Andaleeb U., Bajomo O., Beatson K., Garrett W., Mehmood M., Ng V., Al-Habsi R., Divya G.S., Keeler B., Al-Sarireh B., Egan R., Harries R., Henry A., Kittur M., Li Z., Parkins K., Soliman F., Spencer N., Thompson D., Burgess C., Gemmell C., Grieco C., Hollyman M., Hunt L., Morrison J., Ojha S., Ryan N., Abbadessa F., Barnard S., Dawe N., Hammond J., Mahmoud Ali F., Mellor C., Moir J., Pandanaboyana S., Powell J., Rai B., Roy C., Sachdeva A., Saleh C., Tingle S., Williams T., Manickavasagam J., Ragupathy K., Ramsay L., Solth A., Kakisi O., Seebah K., Shaikh I., Sreedharan L., Youssef M., Shah J., Ameerally P., Mills S., Shenfine A., Sahnan K., Abu J., Addae-Boateng E., Bratt D., Brock L., Burnside N., Cadwell-Sneath S., Gajjar K., Gan C., Grundy C., Hallam K., Hassell K., Hawari M., Joshi A., Khout H., Konstantinidi K., Rxn L., Nunns D., Schiemer R., Walton T., Weaver H., Whisker L., Williamson K., Myatt R., Kaur R., Michel M., Patil S., Ravindran S., Sarveswaran J., Scott L., Edmond M., King E., Breik O., Griffiths E., Idle M., Kamal M., Kisiel A., Kulkarni R., Jkc M., Martin T., Parente A., Parmar S., Pathanki A.M., Phelan L., Praveen P., Saeed S., Singh J., Vijayan D., Geddes A., Khan A.H., Khan F., Mansuri A., Mukherjee S., Sarigul M., Singh S., Tan K.L., Woodham A., Adiamah A., Brewer H., Chowdhury A., Evans J., Humes D., Jackman J., Koh A., Lewis-Lloyd C., Oyende O., Reilly J., Worku D., Cool P., Cribb G., Shepherd K., Bisset C., Elson N., Faulkner G., Saleh P., Underwood C., Brixton G., Findlay L., Majkowska A., Manson J., Potter R., Bhalla A., Chia Z., Daliya P., Goyal A., Grimley E., Hamad A., Kumar A., Malcolm F.L., Theophilidou E., Bowden J., Campain N., Daniels I., Fowler G., John J., Massey L., Ng M., Pascoe J., Rajaretnam N., Bulathsinhala S., Davidson B., Fusai G., Hidalgo Salinas C., Machairas N., Pissanou T., Pollok J.M., Raptis D.A., Soggiu F., Tzerbinis H., Xyda S.E., Beamish A., Davies E., Foulkes R., Magowan D., Nassa H., Ooi R., Price C., Smith L., Solari F., Tang A., Williams G., Al-Tamimi Y., Bacon A., Beasley N., Chew D., Crank M., Ilenkovan N., Macdonald M., Narice B., Rominiyi O., Thompson A., Varley I., Drake T., Harrison E., Linder G., Mayes J., Skipworth R., Zamvar V., Hawkin P., Raymond T., Ryska O., Baron R., Dunne D., Gahunia S., Halloran C., Howes N., Russ J., Szatmary P., Tan J.R., Thomas A., Whelan P., Anzak A., Banerjee A., Fuwa O., Hughes F., Knowles C., Kocher H., Leal Silva I., Ledesma F.S., Minicozzi A., Navaratne L., Rahman R., Ramamoorthy R., Sohrabi C., Thaha M., Thakur B., Venn M., Yip V., Baumber R., Parry J., Evans S., Jeys L., Morris G., Parry M., Ahmadi N., Aresu G., Barrett-Brown Z.M., Durio Yates H., Gearon D., Hogan J., King M., Peryt A., Pradeep I.S., Adishesh M., Atherton R., Baxter K., Brocklehurst M., Chaudhury M., Krishnamohan N., Owens G., Parkin E., Patkar P., Phang I., Aladeojebi A., Ali M., Barmayehvar B., Gaunt A., Gowda M., Halliday E., Kitchen M., Mansour F., Thomas M., Zakai D., Abbassi-Ghadi N., Assalaarachchi H., Currie A., Flavin M., Frampton A., Hague M., Hammer C., Hopper J., Horsnell J., Humphries S., Kamocka A., Madhuri T.K., Preston S., Singh P., Stebbing J., Tailor A., Walker D., Aljanadi F., Jones M., Mhandu P., O'Donnell C., Turkington R., Al-Ishaq Z., Bhasin S., Bodla A.S., Burahee A., Crichton A., Fossett R., Pigadas N., Rahman E., Snee D., Yassin N., Fountain D., Hasan M.T., Karabatsou K., Laurente R., Pathmanaban O., Al-mukhtar A., Giblin A., Kelty C., Lee M., Lye G., Newman T., Sharkey A., Steele C., Sureshkumar Shah N., Whitehall E., Athwal R., Baker A., Jones L., Konstantinou C., Ramcharan S., Vatish J., Wilkin R., Ethunandan M., Sekhon G.K., Shields H., Singh R., Wensley F., Lyons A., Abbott T., Anwar S., Ghufoor K., Chung E., Hagger R., Hainsworth A., Karim A., Owen H., Ramwell A., Williams K., Baker C., Davies A., Gossage J., Kelly M., Knight W., Hall J., Harris G., James G., Kang C., Lin D.J., Rajgor A.D., Royle T., Scurrah R., Steel B., Watson L.J., Choi D., Hutchison R., Jain A., Luoma V., Marcus H., May R., Menon A., Pramodana B., Webber L., Aneke I.A., Asaad P., Brown B., Collis J., Duff S., Khan A., Moura F., Wadham B., Warburton H., Elmoslemany T., Jenkinson M., Millward C., Zakaria R., Mccluney S., Parmar C., Shah S., Allison J., Collard B., Goodrum S., Lau K., Scott R., Thomas E., Whitmore H., Balasubramaniam D., Jayasankar B., Kapoor S., Ramachandran A., Elhamshary A., Smb I., Kapriniotis K., Lindsay J., Rakhshani-Moghadam S., Beech N., Chand M., Green L., Kalavrezos N., Kiconco H., Schilling C., Sinha D., Pereca J., Chopra S., Egbeare D., Thomas R., Combellack T., Sef J., Kornaszewska M., Mohammed M., Sharma A., Tahhan G., Valtzoglou V., Williams J., Eskander P., Gash K., Gourbault L., Hanna M., Maccabe T., Newton C., Olivier J., Rozwadowski S., Teh E., West D., Al-omishy H., Baig M., Bates H., Di Taranto G., Dickson K., Dunne N., Gill C., Howe D., Jeevan D., Khajuria A., Martin-Ucar A., Naredla P., Robertson S., Sait M., Sarma D.R., Shanbhag S., Shortland T., Simmonds S., Skillman J., Tewari N., Walton G., Sgro A., Stewart K.E., Turnbull A., Aguilar Gonzalez M., Talukder S., Boyle C., Fernando D., Gallagher K., Laird A., Tham D., Bath M., Patki P., Tanabalan C., Arif T., Magee C., Nambirajan T., Powell S., Vinayagam R., Flindall I., Hanson A., Mahendran V., Green S., Lim M., Miu V., Onos L., Sheridan K., Young R., Alam F., Griffiths O., Houlden C., Jones R., Kolli V.S., Lala A.K., Leeson S., Peevor R., Seymour Z., Chen L., Henderson E., Brown K., Fleming D., Heron C., Hill C., Kay H., Leede E., Olson K., Osterberg E.C., Riley C., Srikanth P., Thornhill M., Blazer D., Hwang E.S., Lee W., Lidsky M., Plichta J., Rosenberger L., Scheri R., Turnage K., Visgauss J., Zani S., Farma J., Clark J., Kwon D., Etchill E., Gabre-Kidan A., Jenny H.E., Kent A., Ladd M., Long C., Malapati H., Margalit A., Rapaport S., Rose J., Stevens K., Tsai L., Vervoort D., Yesantharao P., Dehal A., Klaristenfeld D., Huynh K., Brown L., Mullinax J., Gusani N., Hazelton J., Maines J., Oh J.S., Ssentongo A., Ssentongo P., Azam M., Choudhry A., Marx W., Fleming J., Fuson A., Gigliotti J., Ovaitt A., Ying Y., Abel M.K., Chern H., Corvera C., El-sayed I., Glencer A., Ha P., Bcs H., Heaton C., Hirose K., Kirkwood K., Kornblith L.Z., Kratz J.R., Lee R., Miller P.N., Nakakura E., Nunez-Garcia B., Ozgediz D., Sarin A., Sheu B., Varma M., Wai K., Xu M.J., Beswick D., Goddard J., Manor J., Song J., Fullmer T., Gaskill C., Gross N., Kiong K., Roland C.L., Zafar S.N., Abdallah M., Abouassi A., Almasri M., Kulkarni G., Marwan H., Mehdi M., Aoun S., Ban V.S., Batjer H.H., Caruso J., Abbott D., Acher A., Aiken T., Barrett J., Foley E., Schwartz P., Hawkins A., Maiga A., Laufer J., Scasso S., Glasbey, J, Nepogodiev, D, Omar, O, Simoes, J, Ademuyiwa, A, Fiore, M, Minaya-Bravo, A, Shaw, R, Vidya, R, Bhangu, A, Siaw-Acheampong, K, Benson, R, Bywater, E, Chaudhry, D, Dawson, B, Evans, J, Gujjuri, R, Heritage, E, Jones, C, Kamarajah, S, Khatri, C, Khaw, R, Keatley, J, Knight, A, Lawday, S, Li, E, Mann, H, Marson, E, Mclean, K, Mckay, S, Mills, E, Pellino, G, Picciochi, M, Taylor, E, Tiwari, A, Trout, I, Venn, M, Wilkin, R, Moug, S, Vimalchandran, D, Vallance, A, Pockney, P, Griffiths, E, Townend, P, Roberts, K, Isaac, J, Satoi, S, Edwards, J, Coonar, A, Marchbank, A, Caruana, E, Layton, G, Patel, A, Brunelli, A, Ford, S, Desai, A, Gronchi, A, Almond, M, Tirotta, F, Dumitra, S, Kolias, A, Price, S, Fountain, D, Jenkinson, M, Hutchinson, P, Marcus, H, Piper, R, Lippa, L, Servadei, F, Esene, I, Freyschlag, C, Neville, I, Rosseau, G, Schaller, K, Demetriades, A, Robertson, F, Alamri, A, Schache, A, 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C, Hallam, K, Hassell, K, Hawari, M, Joshi, A, Khout, H, Konstantinidi, K, Rxn, L, Nunns, D, Schiemer, R, Walton, T, Weaver, H, Whisker, L, Williamson, K, Myatt, R, Kaur, R, Michel, M, Patil, S, Ravindran, S, Sarveswaran, J, Scott, L, Edmond, M, King, E, Breik, O, Idle, M, Kamal, M, Kisiel, A, Kulkarni, R, Jkc, M, Martin, T, Parente, A, Parmar, S, Pathanki, A, Phelan, L, Praveen, P, Saeed, S, Vijayan, D, Geddes, A, Khan, A, Khan, F, Mansuri, A, Mukherjee, S, Sarigul, M, Singh, S, Tan, K, Woodham, A, Adiamah, A, Brewer, H, Chowdhury, A, Humes, D, Jackman, J, Koh, A, Lewis-Lloyd, C, Oyende, O, Reilly, J, Worku, D, Cool, P, Cribb, G, Shepherd, K, Bisset, C, Elson, N, Faulkner, G, Saleh, P, Underwood, C, Brixton, G, Findlay, L, Majkowska, A, Manson, J, Potter, R, Bhalla, A, Chia, Z, Daliya, P, Goyal, A, Grimley, E, Hamad, A, Kumar, A, Malcolm, F, Theophilidou, E, Bowden, J, Campain, N, Daniels, I, Fowler, G, John, J, Massey, L, Ng, M, Pascoe, J, Rajaretnam, N, Bulathsinhala, S, Davidson, 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Patkar, P, Phang, I, Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Thomas, M, Zakai, D, Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, Madhuri, T, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D, Aljanadi, F, Jones, M, Mhandu, P, O'Donnell, C, Turkington, R, Al-Ishaq, Z, Bhasin, S, Bodla, A, Burahee, A, Crichton, A, Fossett, R, Pigadas, N, Rahman, E, Snee, D, Yassin, N, Hasan, M, Karabatsou, K, Laurente, R, Pathmanaban, O, Al-mukhtar, A, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E, Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Ethunandan, M, Sekhon, G, Shields, H, Singh, R, Wensley, F, Lyons, A, Abbott, T, Anwar, S, Ghufoor, K, Chung, E, Hagger, R, Hainsworth, A, Karim, A, Owen, H, Ramwell, A, Williams, K, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W, Hall, J, Harris, G, James, G, Kang, C, Lin, D, Rajgor, A, Royle, T, Scurrah, R, Steel, B, Watson, L, Choi, D, Hutchison, R, Jain, A, Luoma, V, May, R, Menon, A, Pramodana, B, Webber, L, Aneke, I, Asaad, P, Brown, B, Collis, J, Duff, S, Moura, F, Wadham, B, Warburton, H, Elmoslemany, T, Millward, C, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, Collard, B, Goodrum, S, Lau, K, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Elhamshary, A, Smb, I, Kapriniotis, K, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Combellack, T, Sef, J, Kornaszewska, M, Mohammed, M, Sharma, A, Tahhan, G, Valtzoglou, V, Williams, J, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, T, Newton, C, Olivier, J, Rozwadowski, S, Teh, E, West, D, Al-omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar, A, Naredla, P, Robertson, S, Sait, M, Sarma, D, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Sgro, A, Stewart, K, Turnbull, A, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Patki, P, Tanabalan, C, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Jones, R, Kolli, V, Lala, A, Leeson, S, Peevor, R, Seymour, Z, Chen, L, Henderson, E, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, Olson, K, Osterberg, E, Riley, C, Srikanth, P, Thornhill, M, Blazer, D, Hwang, E, Lee, W, Lidsky, M, Plichta, J, Rosenberger, L, Scheri, R, Turnage, K, Visgauss, J, Zani, S, Farma, J, Clark, J, Kwon, D, Etchill, E, Gabre-Kidan, A, Jenny, H, Kent, A, Ladd, M, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Brown, L, Mullinax, J, Gusani, N, Hazelton, J, Maines, J, Oh, J, Ssentongo, A, Ssentongo, P, Azam, M, Choudhry, A, Marx, W, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, M, Chern, H, Corvera, C, El-sayed, I, Glencer, A, Ha, P, Bcs, H, Heaton, C, Hirose, K, Kirkwood, K, Kornblith, L, Kratz, J, Lee, R, Miller, P, Nakakura, E, Nunez-Garcia, B, Ozgediz, D, Sarin, A, Sheu, B, Varma, M, Wai, K, Xu, M, Beswick, D, Goddard, J, Manor, J, Song, J, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, C, Zafar, S, Abdallah, M, Abouassi, A, Almasri, M, Kulkarni, G, Marwan, H, Mehdi, M, Aoun, S, Ban, V, Batjer, H, Caruso, J, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, P, Hawkins, A, Maiga, A, Laufer, J, Scasso, S, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), COVIDSurg Collaborative, Glasbey, J. C., Nepogodiev, D., Omar, O., Simoes, J. F. F., Ademuyiwa, A., Fiore, M., Minaya-Bravo, A., Shaw, R., Vidya, R., Bhangu, A., Bhangu, A. A., Siaw-Acheampong, K., Benson, R., Bywater, E., Chaudhry, D., Dawson, B. E., Evans, J. P., Gujjuri, R. R., Heritage, E., Jones, C. S., Kamarajah, S. K., Khatri, C., Khaw, R. A., Keatley, J. M., Knight, A., Lawday, S., Li, E., Mann, H. S., Marson, E. J., Mclean, K. A., Mckay, S. C., Mills, E. C., Pellino, G., Picciochi, M., Taylor, E. H., Tiwari, A., Trout, I. M., Venn, M. L., Wilkin, R. J. W., Moug, S., Vimalchandran, D., Vallance, A., Pockney, P. G., Griffiths, E. A., Townend, P., Roberts, K., Mckay, S., Isaac, J., Satoi, S., Edwards, J., Coonar, A. S., Marchbank, A., Caruana, E. J., Layton, G. R., Patel, A., Brunelli, A., Ford, S., Desai, A., Gronchi, A., Almond, M., Tirotta, F., Dumitra, S., Kolias, A., Price, S. J., Fountain, D. M., Jenkinson, M. D., Hutchinson, P., Marcus, H. J., Piper, R. J., Lippa, L., Servadei, F., Esene, I., Freyschlag, C., Neville, I., Rosseau, G., Schaller, K., Demetriades, A. K., Robertson, F., Alamri, A., Schache, A. G., Winter, S. C., Ho, M., Nankivell, P., Biel, J. R., Batstone, M., Ganly, I., Wilkins, A., Singh, J. K., Thekinkattil, D., Sundar, S., Fotopoulou, C., Leung, E., Khan, T., Chiva, L., Sehouli, J., Fagotti, A., Cohen, P., Gutelkin, M., Ghebre, R., Konney, T., Pareja, R., Bristow, R., Dowdy, S., Rajkumar, S. T. S., Ng, J., Fujiwara, K., Stewart, G. D., Lamb, B., Narahari, K., Mcneill, A., Colquhoun, A., Mcgrath, J., Bromage, S., Barod, R., Kasivisvanathan, V., Klatte, T., Committee, D., Adamina, M., Ademuyiwa, A. O., Agarwal, A., Alameer, E., Alderson, D., Alakaloko, F., Albertsmeiers, M., Alser, O., Alshaar, M., Alshryda, S., Arnaud, A. P., Augestad, K. M., Ayasra, F., Azevedo, J., Bankhead-Kendall, B. K., Barlow, E., Benson, R. A., Blanco-Colino, R., Brar, A., Breen, K. A., Buarque, I. L., Chaar, M., Chakrabortee, S., Christensen, P., Cox, D., Cukier, M., Cunha, M. F., Davidson, G. H., Di Saverio, S., Drake, T. M., Edwards, J. G., Elhadi, M., Farik, S., Fitzgerald, J. E., Garmanova, T., Gallo, G., Ghosh, D., Gomes, G. M. A., Grecinos, G., Grundl, M., Halkias, C., Harrison, E. M., Hisham, I., Hutchinson, P. J., Hwang, S., Isik, A., Jonker, P., Lawani, I., Lederhuber, H., Leventoglu, S., Litvin, A., Loehrer, A., Loffler, M. W., Lorena, M. A., Madolo, M. M., Major, P., Martin, J., Mashbari, H. N., Mazingi, D., Metallidis, S., Mohan, H. M., Moore, R., Moszkowicz, D., Ng-Kamstra, J. S., Maimbo, M., Niquen, M., Ntirenganya, F., Olivos, M., Oussama, K., Outani, O., Parreno-Sacdalanm, M. D., Pata, F., Rivera, C. J. P., Pinkney, T. D., Qureshi, A., Radenkovic, D., la Medina, A. R. -D., Roslani, A. C., Rutegard, M., Santos, I., Sayyed, R., Schnitzbauer, A. A., Sharma, N., Shu, S., Soreide, K., Spinelli, A., Sund, M., Tabiri, S., Tsoulfas, G., van Ramshorst, G. H., Vimalachandran, D., Warren, O. J., Wedderburn, D., Wright, N., Allemand, C., Boccalatte, L., Figari, M., Lamm, M., Larranaga, J., Marchitelli, C., Noll, F., Odetto, D., Perrotta, M., Saadi, J., Zamora, L., Alurralde, C., Caram, E. L., Eskinazi, D., Mendoza, J. P., Usandivaras, M., Badra, R., Esteban, A., Garcia, J. S., Garcia, P. M., Gerchunoff, J. I., Lucchini, S. M., Vargas, L., Hovhannisyan, T., Stepanyan, A., Gould, T., Gourlay, R., Griffiths, B., Gananadha, S., Cecire, J., Joshi, N., Salindera, S., Sutherland, A., Ahn, J. H., Charlton, G., Chen, S., Gauri, N., Hayhurst, R., Jang, S., Jia, F., Mulligan, C., Yang, W., Ye, G., Zhang, H., Ballal, M., Gibson, D., Hayne, D., Moss, J., Richards, T., Viswambaram, P., Vo, U. G., Bennetts, J., Bright, T., Brooke-Smith, M., Fong, R., Gricks, B., Lam, Y. H., Szpytma, M., Watson, D., Bagraith, K., Caird, S., Chan, E., Dawson, C., Ho, D., Jeyarajan, E., Jordan, S., Lim, A., Nolan, G. J., Oar, A., Parker, D., Puhalla, H., Quennell, A., Rutherford, L., Von Papen, M., Wullschleger, M., Blatt, A., Cope, D., Egoroff, N., Fenton, M., Gani, J., Lott, N., Shugg, N., Elliott, M., Phung, D., Phan, D., Townend, D., Bong, C., Gundara, J., Frankel, A., Bowman, S., Guerra, G. R., Bolt, J., Buddingh, K., Dudi-Venkata, N. N., Jog, S., Kroon, H. M., Sammour, T., Smith, R., Stranz, C., Lah, K., Mitchell, D., Morton, A., Pearce, A., Roberts, M., Sheahan, G., Swinson, B., Alam, N., Banting, S., Chong, L., Choong, P., Clatworthy, S., Foley, D., Fox, A., Hii, M. 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E., Ashoush, F., Atta, R., Elazzazy, E., Elhoseiny, M., Elnemr, M., Elsherbini, I., Essam, E., Eweda, M., Ghallab, I., Hassan, E., Ibrahim, M., Metwalli, M., Mourad, M., Ragab, M., Sabry, A., Saifeldin, H., Samih, A., Samir Abdelaal, A., Shehata, S., Shenit, K., Attia, D., Kamal, N., Osman, N., Abbas, A. M., Has, A. E., Alaa, S., Ali, A. K., Ayman, A., Azizeldine, M. G., Elkhayat, H., Monib, F. A., Salah, M., Shahine, M., Yousof, E. A., Youssef, A., Eldaly, A., Nabil, A., Amira, G., Sallam, I., Sherief, M., Sherif, A., Abdelrahman, A., Aboulkassem, H., Ghaly, G., Hamdy, R., Morsi, A., Sherif, G., Abdeldayem, H., Abdelkader Salama, I., Balabel, M., Fayed, Y., Sherif, A. E., Bekele, D., Kauppila, J., Sarjanoja, E., Helminen, O., Huhta, H., Kauppila, J. H., Beyrne, C., Jouffret, L., Lugans, L., Marie-Macron, L., Chouillard, E., De Simone, B., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Testelin, S., Boucher, S., Breheret, R., Gueutier, A., Kahn, A., Kun-Darbois, J., Barrabe, A., Lakkis, Z., Louvrier, A., Manfredelli, S., Mathieu, P., Chebaro, A., Drubay, V., Eveno, C., Lecolle, K., Legault, G., Martin, L., Piessen, G., Pruvot, F. R., Truant, S., Zerbib, P., Ballouhey, Q., Barrat, B., Laloze, J., Salle, H., Taibi, A., Usseglio, J., Bergeat, D., Merdrignac, A., Le Roy, B., Perotto, L. O., Scalabre, A., Aime, A., Ezanno, A., Malgras, B., Bouche, P., Tzedakis, S., Cotte, E., Glehen, O., Lifante, J., Felli, E., Mutter, D., Pessaux, P., Seeliger, B., Bardet, J., Berry, R., Boddaert, G., Bonnet, S., Brian, E., Denet, C., Fuks, D., Gossot, D., Grigoroiu, M., Laforest, A., Levy-Zauberman, Y., Louis-Sylvestre, C., Moumen, A., Pourcher, G., Seguin-givelet, A., Tribillon, E., Duchalais, E., Espitalier, F., Ferron, C., Malard, O., Bork, U., Distler, M., Fritzmann, J., Kirchberg, J., Praetorius, C., Riediger, C., Weitz, J., Welsch, T., Wimberger, P., Beyer, K., Kamphues, C., Lauscher, J., Loch, F. N., Schineis, C., Albertsmeier, M., Angele, M., Kappenberger, A., Niess, H., Schiergens, T., Jonescheit, J., Pergolini, I., Reim, D., Boeker, C., Hakami, I., Mall, J., Liokatis, P., Smolka, W., Nowak, K., Reinhard, T., Holzle, F., Modabber, A., Winnand, P., Knitschke, M., Kauffmann, P., Wolfer, S., Kleeff, J., Lorenz, K., Michalski, C., Ronellenfitsch, U., Schneider, R., Bertolani, E., Konigsrainer, A., Quante, M., Steidle, C., Uberruck, L., Yurttas, C., Betz, C. S., Bewarder, J., Bottcher, A., Burg, S., Busch, C., Gosau, M., Heuer, A., Izbicki, J., Koenig, D., Moeckelmann, N., Nitschke, C., Priemel, M., Smeets, R., Speth, U., Thole, S., Uzunoglu, F. G., Vollkommer, T., Zeller, N., Battista, M. J., Gillen, K., Hasenburg, A., Krajnak, S., Linz, V., Schwab, R., Angelou, K., Haidopoulos, D., Rodolakis, A., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Fragulidis, G., Gklavas, A., Konstadoulakis, M., Memos, N., Papaconstantinou, I., Polydorou, A., Theodosopoulos, T., Vezakis, A., Antonopoulou, M. I., Manatakis, D. K., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Tsaousis, V., Vassiliu, P., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Baxevanidou, K., Bouliaris, K., Chatzikomnitsa, P., Efthimiou, M., Giaglaras, A., Kalfountzos, C., Koukoulis, G., Ntziovara, A. M., Petropoulos, K., Soulikia, K., Tsiamalou, I., Zervas, K., Zourntou, S., Baloyiannis, I., Diamantis, A., Gkrinia, E., Hajiioannou, J., Korais, C., Koukoura, O., Perivoliotis, K., Saratziotis, A., Skoulakis, C., Symeonidis, D., Tepetes, K., Tzovaras, G., Zacharoulis, D., Alexoudi, V., Antoniades, K., Astreidis, I., Christidis, P., Deligiannidis, D., Grivas, T., Ioannidis, O., Kalaitsidou, I., Loutzidou, L., Mantevas, A., Michailidou, D., Paraskevopoulos, K., Politis, S., Stavroglou, A., Tatsis, D., Tilaveridis, I., Vahtsevanos, K., Venetis, G., Karaitianos, I., Tsirlis, T., Charalabopoulos, A., Liakakos, T., Mpaili, E., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Anthoulakis, C., Christou, C., Papadopoulos, V., Tooulias, A., Tsolakidis, D., Zouzoulas, D., Athanasakis, E., Chrysos, E., Tsiaousis, J., Xenaki, S., Xynos, E., Banky, B., Susztak, N., Bhat, G. A., Chowdri, N., Mehraj, A., Parray, F., Dza, S., Wani, R., Ahmed, Z., Bali, R., Laharwal, A., Mahmood, M., Mir, I., Mohammad, Z., Muzamil, J., Rashid, A., Rather, M. H., Aremu, M., Canas-Martinez, A., Cullivan, O., Murphy, C., Owens, P., Pickett, L., Akmenkalne, L., Byrne, J., Corrigan, M., Cullinane, C., Daly, A., Fleming, C., Jordan, P., Killeen, S., Lynch, N., Mustafa, H., O'Brien, S., O'Leary, P., Was, S., Vernon, L., Callanan, D., Huang, L., Ionescu, A., Sheahan, P., Balasubramanian, I., Boland, M., Conlon, K., Evoy, D., Fearon, N., Gallagher, T., Geraghty, J., Heneghan, H., Kennedy, N., Maguire, D., Mcdermott, E. W., Prichard, R. S., Winter, D., Alazawi, D., Barry, C., Boyle, T., Butt, W., Connolly, E. M., Donlon, N., Donohue, C., Farrell, R., Fitzgerald, C., Kinsella, J., Larkin, J. O., Lennon, P., Maguire, P. J., Mccormick, P., Mehigan, B. J., Mohan, H., Nugent, T., O'Sullivan, H., Ravi, N., Reynolds, J. V., Rogers, A., Shokuhi, P., Smith, J., Smith, L. A., Timon, C., Bashir, Y., Bass, G., Connelly, T., Earley, H., Elliott, J. A., Gillis, A., Kavanagh, D., Neary, P., O'Riordan, J., Reynolds, I. S., Rice, D., Ridgway, P., Umair, M., Whelan, M., Carroll, P., Collins, C., Corless, K., Finnegan, L., Fowler, A., Hogan, A., Kerin, M., Lowery, A., Nizami, K., Ryan, E., Samy, A., Coffey, J. C., Cunningham, R., Devine, M., Nally, D., Peirce, C., Tormey, S., Hardy, N., O'Malley, S., Ryan, M., Macina, S., Mariani, N. M., Opocher, E., Pisani Ceretti, A., Ferrari, F., Odicino, F., Sartori, E., Cotsoglou, C., Granieri, S., Bianco, F., Colledan, M., Tornese, S., Zambelli, M. F., Bissolotti, G., Fusetti, S., Lemma, F., Marino, M., Mirabella, A., Vaccarella, G., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Risaliti, M., Sorbi, F., Taddei, A., Tucci, R., Bassi, C., Campagnaro, T., Casetti, L., De Pastena, M., Esposito, A., Fontana, M., Guglielmi, A., Landoni, L., Malleo, G., Marchegiani, G., Nobile, S., Paiella, S., Pedrazzani, C., Rattizzato, S., Ruzzenente, A., Salvia, R., Turri, G., Tuveri, M., Bellora, P., Ferrari, M., Francone, E., Gentilli, S., Nikaj, H., Bianchini, M., Chiarugi, M., Coccolini, F., Di Franco, G., Furbetta, N., Gianardi, D., Guadagni, S., Morelli, L., Palmeri, M., Tartaglia, D., Anania, G., Carcoforo, P., Chiozza, M., De Troia, A., Koleva Radica, M., Portinari, M., Sibilla, M. G., Urbani, A., Fabbri, N., Feo, C. V., Gennari, S., Parini, S., Righini, E., Ampollini, L., Bellanti, L., Bergonzani, M., Bertoli, G., Bocchialini, G., Lanfranco, D., Musini, L., Poli, T., Santoro, G. P., Varazzani, A., Aguzzoli, L., Borgonovo, G., Castro Ruiz, C., Coiro, S., Falco, G., Mandato, V. D., Mastrofilippo, V., Montella, M. T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Irccs, O. M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone Federico, N. S., Bambina, F., Familiari, P., Picotti, V., DE PALMA, GIOVANNI DOMENICO, Luglio, Gaetano, Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni, A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Capizzi, V., Spb, C., Citterio, D., Comini, L. V., Cosimelli, M., Folli, S., Gennaro, M., Giannini, L., Guaglio, M., Macchi, A., Martinelli, F., Mazzaferro, V., Mosca, A., Pasquali, S., Piazza, C., Raspagliesi, F., Rolli, L., Salvioni, R., Sarpietro, G., Sarre, C., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., De Simone, V., Gasparini, G., Gordini, L., Litta, F., Lombardi, C. P., Lorenzon, L., Marra, A. A., Marzi, F., Moro, A., Parello, A., Perrone, E., Persiani, R., Ratto, C., Rosa, F., Saponaro, G., Scambia, G., Scrima, O., Sganga, G., Tudisco, R., Belli, A., Granata, V., Izzo, F., Palaia, R., Patrone, R., Carrano, F. M., De Virgilio, A., Di Candido, F., Ferreli, F., Gaino, F., Mercante, G., Rossi, V., Emanuele, P., Frisoni, T., Palmerini, E., Aprile, A., Barra, F., Batistotti, P., Ferrero, S., Fregatti, P., Scabini, S., Sparavigna, M., Asti, E., Bernardi, D., Bonavina, L., Lovece, A., Adamoli, L., Ansarin, M., Cenciarelli, S., Chu, F., De Berardinis, R., Fumagalli Romario, U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino Cosentino, L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., Depalma, N., Spampinato, M. G., Bartolucci, P., Brachini, G., Bruzzaniti, P., Chiappini, A., Chiarella, V., Ciccarone, F., Cicerchia, P. M., Cirillo, B., De Toma, G., Di bartolomeo, A., Fiori, E., Fonsi, G. B., Franco, G., Frati, A., Giugliano, M., Iannone, I., La Torre, F., Lapolla, P., Leonardo, C., Marruzzo, G., Meneghini, S., Mingoli, A., Ribuffo, D., Salvati, M., Santoro, A., Sapienza, P., Scafa, A. K., Simonelli, L., Zambon, M., Capolupo, G. T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., De Nardi, P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Ottolina, J., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. 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F., Mohammad, A., Nakas, A., Rathinam, S., Boal, M., Brown, O., Dwerryhouse, S., Higgs, S., Boyd, E., Irvine, V., Kirk, A., Bakolas, G., Boulton, A., Chandock, A., Kumar, M., Agoston, P., Bille, A., Challacombe, B., Fraser, S., Harrison-Phipps, K., King, J., Mehra, G., Mills, L., Najdy, M., Nath, R., Okiror, L., Pilling, J., Rizzo, V., Routledge, T., Sayasneh, A., Stroman, L., Wali, A., Fehervari, M., Habib, N., Hamrang-Yousefi, S., Jawad, Z., Jiao, L., Pai, M., Ploski, J., Rajagopal, P., Saso, S., Sodergren, M., Spalding, D., Laws, S., Hardie, C., Alam, R., Budacan, A., Cahill, J., Kalkat, M., Karandikar, S., Kenyon, L., Naumann, D., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem Ibrahim, A., Bichoo, R., Cao, H., Akw, C., Choudhury, J., Evans, C., Fitzjohn, H., Ikram, H., Langstroth, M., Loubani, M., Nazir, S., Ssa, Q., Robinson, A., Ross, E., Sehgal, T., Dixon, J., Dunning, J., Freystaetter, K., Jha, M., Lester, S., Madhavan, A., Thulasiraman, S. V., Viswanath, Y., Curl-Roper, T., Delimpalta, C., Ccl, L., Velchuru, V., Westwood, E., Belcher, E., Bond-Smith, G., Chidambaram, S., Di Chiara, F., Fasanmade, K., Fraser, L., Fu, H., Ganau, M., Gore, S., Graystone, J., Jeyaretna, D., Khatkar, H., Lami, M., Maher, M., Mastoridis, S., Mihai, R., Piper, R., Prabhu, S., Obf, R., Selbong, U., Shah, K., Smillie, R., Sravanam, S., Stavroulias, D., Tebala, G. D., Vatish, M., Verberne, C., Wallwork, K., Winter, S., Bhatti, M. I., Boyd-Carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Bourke, G., Bradshaw, L., Burke, J., Coe, P., Costigan, F., Elkadi, H., Johnstone, J., Kanatas, A., Kantola, V., Kaufmann, A., Laios, A., Lam, S., Munot, S., Nahm, C., Otify, M., Pompili, C., Smith, I., Theophilou, G., Toogood, G., Wade, R., Ward, D., West, C., Annamalai, S., Ashmore, C., Boddy, A., Hossain, T., Kourdouli, A., Gvaramadze, A., Jibril, A., Prusty, L., Thekkinkattil, D., Harky, A., Shackcloth, M., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Shaw, S., Talwar, R., Abdalla, M., Edmondson, R., Ismail, O., Jones, D., Newton, K., Stylianides, N., Aderombi, A., Andaleeb, U., Bajomo, O., Beatson, K., Garrett, W., Mehmood, M., Ng, V., Al-Habsi, R., Divya, G. S., Keeler, B., Al-Sarireh, B., Egan, R., Harries, R., Henry, A., Kittur, M., Li, Z., Parkins, K., Soliman, F., Spencer, N., Thompson, D., Burgess, C., Gemmell, C., Grieco, C., Hollyman, M., Hunt, L., Morrison, J., Ojha, S., Ryan, N., Abbadessa, F., Barnard, S., Dawe, N., Hammond, J., Mahmoud Ali, F., Mellor, C., Moir, J., Pandanaboyana, S., Powell, J., Rai, B., Roy, C., Sachdeva, A., Saleh, C., Tingle, S., Williams, T., Manickavasagam, J., Ragupathy, K., Ramsay, L., Solth, A., Kakisi, O., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Ameerally, P., Mills, S., Shenfine, A., Sahnan, K., Abu, J., Addae-Boateng, E., Bratt, D., Brock, L., Burnside, N., Cadwell-Sneath, S., Gajjar, K., Gan, C., Grundy, C., Hallam, K., Hassell, K., Hawari, M., Joshi, A., Khout, H., Konstantinidi, K., Rxn, L., Nunns, D., Schiemer, R., Walton, T., Weaver, H., Whisker, L., Williamson, K., Myatt, R., Kaur, R., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Edmond, M., King, E., Breik, O., Griffiths, E., Idle, M., Kamal, M., Kisiel, A., Kulkarni, R., Jkc, M., Martin, T., Parente, A., Parmar, S., Pathanki, A. M., Phelan, L., Praveen, P., Saeed, S., Singh, J., Vijayan, D., Geddes, A., Khan, A. H., Khan, F., Mansuri, A., Mukherjee, S., Sarigul, M., Singh, S., Tan, K. L., Woodham, A., Adiamah, A., Brewer, H., Chowdhury, A., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis-Lloyd, C., Oyende, O., Reilly, J., Worku, D., Cool, P., Cribb, G., Shepherd, K., Bisset, C., Elson, N., Faulkner, G., Saleh, P., Underwood, C., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Goyal, A., Grimley, E., Hamad, A., Kumar, A., Malcolm, F. L., Theophilidou, E., Bowden, J., Campain, N., Daniels, I., Fowler, G., John, J., Massey, L., Ng, M., Pascoe, J., Rajaretnam, N., Bulathsinhala, S., Davidson, B., Fusai, G., Hidalgo Salinas, C., Machairas, N., Pissanou, T., Pollok, J. M., Raptis, D. A., Soggiu, F., Tzerbinis, H., Xyda, S. E., Beamish, A., Davies, E., Foulkes, R., Magowan, D., Nassa, H., Ooi, R., Price, C., Smith, L., Solari, F., Tang, A., Williams, G., Al-Tamimi, Y., Bacon, A., Beasley, N., Chew, D., Crank, M., Ilenkovan, N., Macdonald, M., Narice, B., Rominiyi, O., Thompson, A., Varley, I., Drake, T., Harrison, E., Linder, G., Mayes, J., Skipworth, R., Zamvar, V., Hawkin, P., Raymond, T., Ryska, O., Baron, R., Dunne, D., Gahunia, S., Halloran, C., Howes, N., Russ, J., Szatmary, P., Tan, J. R., Thomas, A., Whelan, P., Anzak, A., Banerjee, A., Fuwa, O., Hughes, F., Knowles, C., Kocher, H., Leal Silva, I., Ledesma, F. S., Minicozzi, A., Navaratne, L., Rahman, R., Ramamoorthy, R., Sohrabi, C., Thaha, M., Thakur, B., Venn, M., Yip, V., Baumber, R., Parry, J., Evans, S., Jeys, L., Morris, G., Parry, M., Ahmadi, N., Aresu, G., Barrett-Brown, Z. M., Durio Yates, H., Gearon, D., Hogan, J., King, M., Peryt, A., Pradeep, I. S., Adishesh, M., Atherton, R., Baxter, K., Brocklehurst, M., Chaudhury, M., Krishnamohan, N., Owens, G., Parkin, E., Patkar, P., Phang, I., Aladeojebi, A., Ali, M., Barmayehvar, B., Gaunt, A., Gowda, M., Halliday, E., Kitchen, M., Mansour, F., Thomas, M., Zakai, D., Abbassi-Ghadi, N., Assalaarachchi, H., Currie, A., Flavin, M., Frampton, A., Hague, M., Hammer, C., Hopper, J., Horsnell, J., Humphries, S., Kamocka, A., Madhuri, T. K., Preston, S., Singh, P., Stebbing, J., Tailor, A., Walker, D., Aljanadi, F., Jones, M., Mhandu, P., O'Donnell, C., Turkington, R., Al-Ishaq, Z., Bhasin, S., Bodla, A. S., Burahee, A., Crichton, A., Fossett, R., Pigadas, N., Rahman, E., Snee, D., Yassin, N., Fountain, D., Hasan, M. 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A., Asaad, P., Brown, B., Collis, J., Duff, S., Khan, A., Moura, F., Wadham, B., Warburton, H., Elmoslemany, T., Jenkinson, M., Millward, C., Zakaria, R., Mccluney, S., Parmar, C., Shah, S., Allison, J., Collard, B., Goodrum, S., Lau, K., Scott, R., Thomas, E., Whitmore, H., Balasubramaniam, D., Jayasankar, B., Kapoor, S., Ramachandran, A., Elhamshary, A., Smb, I., Kapriniotis, K., Lindsay, J., Rakhshani-Moghadam, S., Beech, N., Chand, M., Green, L., Kalavrezos, N., Kiconco, H., Schilling, C., Sinha, D., Pereca, J., Chopra, S., Egbeare, D., Thomas, R., Combellack, T., Sef, J., Kornaszewska, M., Mohammed, M., Sharma, A., Tahhan, G., Valtzoglou, V., Williams, J., Eskander, P., Gash, K., Gourbault, L., Hanna, M., Maccabe, T., Newton, C., Olivier, J., Rozwadowski, S., Teh, E., West, D., Al-omishy, H., Baig, M., Bates, H., Di Taranto, G., Dickson, K., Dunne, N., Gill, C., Howe, D., Jeevan, D., Khajuria, A., Martin-Ucar, A., Naredla, P., Robertson, S., Sait, M., Sarma, D. 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H., Caruso, J., Abbott, D., Acher, A., Aiken, T., Barrett, J., Foley, E., Schwartz, P., Hawkins, A., Maiga, A., Laufer, J., Scasso, S., Donati DM., Pignatti M., Pinto V., Pockney, P., Schache, A., De Palma, G., Luglio, G., and Wilkin, R.
Subjects: SARS Virus, Coronavirus, Severe Acute Respiratory Syndrome, cancer, surgery pandemic infection, Settore MED/06 - Oncologia Medica, Settore MED/18 - CHIRURGIA GENERALE, Settore MED/29 - CHIRURGIA MAXILLOFACCIALE, COVID-19. Global surgery, Settore MED/19 - Chirurgia Plastica, Comorbidity, 030230 surgery, Covid, COVID-19 / epidemiology, surgery, 0302 clinical medicine, Neoplasms / surgery, Neoplasms, COVID-19, Humans, Surgical Procedures, Operative, Pandemics, SARS-CoV-2, Time-to-Treatment, Prospective cohort study, 610 Medicine & health, COVID-19/epidemiology, medicine.diagnostic_test, Surgery sars-cov-2, covid surg, surgery pandemic infection, Pulmonary Complication, SARS cov 2, Covid19, Surgical Procedures, Operative / methods, Operative, Sars-CoV-2, Surgery sars-cov-2, Neoplasms / epidemiology, Cohort study, Human, medicine.medical_specialty, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, NO, Throat culture, 03 medical and health sciences, Settore MED/28 - Malattie Odontostomatologiche, medicine, Research Letter, Elective surgery, General, covid surg, Surgical Procedures, Pandemic, business.industry, No key words available, Postoperative complication, Perioperative, medicine.disease, Surgery, Pneumonia, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Neoplasm, Surgical Procedures, Operative/methods, business, Neoplasms/epidemiology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: With at least 28 elective million operations delayed during the first three months of the COVID-19 pandemic, the number of patients who will require surgery after a previous SARS-CoV-2 infection is likely to increase rapidly1. Operating on patients with an active perioperative SARS-CoV-2 infection is now known to carry a very high pulmonary complication and mortality rate2. Urgent information is needed to guide whether postponing surgery in patients with a previous SARS-CoV-2 infection leads to a clinical benefit, and the optimal length of delay.
Published: 2020

49. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry

Author: Jerjes-Sanchez C., Corbalan R., Barretto A. C. P., Luciardi H. L., Allu J., Illingworth L., Pieper K. S., Kayani G., Fitzmaurice D. A., Goto S., Hacke W., Mantovani L. G., Turpie A. G. G., Gersh B. J., Gibbs H., Brodmann M., Cools F., Connolly S. J., Spyropoulos A., Eikelboom J., Hu D., Jansky P., Nielsen J. D., Ragy H., Raatikainen P., Le Heuzey J. -Y., Darius H., Keltai M., Kakkar S., Sawhney J. P. S., Agnelli G., Ambrosio G., Koretsune Y., Diaz C. J. S., ten Cate H., Atar D., Stepinska J., Panchenko E., Lim T. W., Jacobson B., Oh S., Vinolas X., Rosenqvist M., Steffel J., Angchaisuksiri P., Parkhomenko A., Al Mahmeed W., Chen K. N., Zhao Y. S., Zhang H. Q., Chen J. Z., Cao S. P., Wang D. W., Yang Y. J., Li W. H., Yin Y. H., Tao G. Z., Yang P., Chen Y. M., He S. H., Wang Y., Fu G. S., Li X., Wu T. G., Cheng X. S., Yan X. W., Zhao R. P., Chen M. S., Xiong L. G., Chen P., Jiao Y., Guo Y., Xue L., Wang F. Z., Li H., Yang Z. M., Bai C. L., Chen J., Chen J. Y., Chen X., Feng S., Fu Q. H., Gao X. J., Guo W. N., He R. H., He X. A., Hu X. S., Huang X. F., Li B., Li J., Li L., Li Y. H., Liu T. T., Liu W. L., Liu Y. Y., Lu Z. C., Luo X. L., Ma T. Y., Peng J. Q., Sheng X., Shi X. J., Sun Y. H., Tian G., Wang K., Wang L., Wu R. N., Xie Q., Xu R. Y., Yang J. S., Yang L. L., Yang Q., Ye Y., Yu H. Y., Yu J. H., Yu T., Zhai H., Zhan Q., Zhang G. S., Zhang Q., Zhang R., Zhang Y., Zheng W. Y., Zhou B., Zhou Z. H., Zhu X. Y., Jadhav P., Durgaprasad R., Ravi Shankar A. G., Rajput R. K., Bhargava K., Sarma R., Srinivas A., Roy D., Nagamalesh U. M., Chopda M., Kishore R., Kulkarni G., Chandwani P., Pothiwala R. A., Padinhare Purayil M., Shah S., Chawla K., Kothiwale V. A., Raghuraman B., Vijayaraghavan G., Vijan V. M., Bantwal G., Bisne V., Khan A., Gupta J. B., Kumar S., Jain D., Abraham S., Adak D., Barai A., Begum H., Bhattacharjee P., Dargude M., Davies D., Deshpande B., Dhakrao P., Dhyani V., Duhan S., Earath M., Ganatra A., Giradkar S., Jain V., Karthikeyan R., Kasala L., Kaur S., Krishnappa S., Lawande A., Lokesh B., Madarkar N., Meena R., More P., Naik D., Prashanth K., Rao M., Rao N. M., Sadhu N., Shah D., Sharma M., Shiva P., Singhal S., Suresh S., Vanajakshamma V., Panse S. 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H., Yoo K. M., Yoon E. J., Yun S. Y., Chawanadelert S., Mongkolwongroj P., Kanokphatcharakun K., Cheewatanakornkul S., Laksomya T., Pattanaprichakul S., Chantrarat T., Rungaramsin S., Silaruks S., Wongcharoen W., Siriwattana K., Likittanasombat K., Katekangplu P., Boonyapisit W., Cholsaringkarl D., Chatlaong B., Chattranukulchai P., Santanakorn Y., Hutayanon P., Khunrong P., Bunyapipat T., Jai-Aue S., Kaewsuwanna P., Bamungpong P., Gunaparn S., Hongsuppinyo S., Inphontan R., Khattaroek R., Khunkong K., Kitmapawanont U., Kongsin C., Naratreekoon B., Ninwaranon S., Phangyota J., Phrommintikul A., Phunpinyosak P., Pongmorakot K., Poomiphol S., Pornnimitthum N., Pumprueg S., Ratchasikaew S., Sanit K., Sawanyawisuth K., Silaruks B., Sirichai R., Sriwichian A., Suebjaksing W., Sukklad P., Suttana T., Tangsirira A., Thangpet O., Tiyanon W., Vorasettakarnkij Y., Wisaratapong T., Wongtheptien W., Wutthimanop A., Yawila S., Altun A., Ozdogru I., Ozdemir K., Yilmaz O., Aydinlar A., Yilmaz M. B., Yeter E., Ongen Z., Cayli M., Pekdemir H., Ozdemir M., Sucu M., Sayin T., Demir M., Yorgun H., Ersanli M., Okuyan E., Aras D., Abdelrahman H., Aktas O., Alpay D., Aras F., Bireciklioglu M. F., Budeyri S., Buyukpapuc M., Caliskan S., Esen M., Felekoglu M. A., Genc D., Ikitimur B., Karaayvaz E. B., Karatas S. K., Okutucu S., Ozcelik E., Quisi A., Sag H., Sahiner L., Sayin B. Y., Seker T., Alkan D. U., Yildirim E., Yildirim R., Yilmaz F., Yuksekdag V., Vensentini N., Ingaramo A. C., Sambadaro G. A., Caputi V. F., Berman S. G., Dragotto P., Kleiban A. J., Centurion N., Giacomi G., Guerrero R. A. A., Conde D., Zapata G., Di Paola L. A., Ramos J. L., Dran R. D., Egido J., Fernandez A. A., Fosco M. J., Sassone S., Sinisi V. A., Cartasegna L. R., Berli M. A., Vilamajo O. A. G., Ferroni F., Alaguibe E. D., D'Amelio A. A., Arabetti C., Arias L., Belardi J. A., Bergesio L., Berli F., Berli M., Borchowiec S., Buzzetti C., Cabrini R., Campisi V., Cappi A. L., Carrizo R., Berra F. 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K., Braga J. C. F., Negri A., Souto L., Moncada C., Precoma D. B., Roquette F., Reis G., Filho R. A. R., Figueiredo E. L., Botelho R. V., Tavares C. M. D. F., Frack C. R. C., Saad J. A., Finimundi H. C., Pisani C., Chemello D., Martins M. P., Franca C. C. B., Alban F., Rosito G. B. A., Moraes Junior J. B. M. X., Tumelero R. T., Maia L. N., de Almeida R. S., do Carmo Borges N. C., Ferreira L. G. G., Agliardi P., Gomes J. A. O., Araujo V., Nakazone M. A., Barbosa T., Barroso S., Falchetto E. B., Lopes H. B., Lemos M. A. B. T., Biazus G., Queiroz L. B., Camazzola F. E., Caporale M., Cardoso Boscato S., Chieza F., Chokr M. O., Mingireanov R. C., Goes N. C., Correa C., Costa M., Ortiz C. C., da Silva L. S., Paulitsch F. D. S., da Silveira J. A., Daros E., de Araujo G. R., Del Monaco M. I., Dias C., Dias M. A., Wainstein A. P. D., Pizzato P. E., Esteves D. C., Fabri P., Fonseca T. F. L., Fernandes E., Fonseca C., Costantini C. R. F., Ferraz R. F., Freire F., Gottardo P., Guanaes D., Guizzardi S., Magedanz E. H., Igansi F., Jannuzzi F., Junior G., Komar D., Lino E. G., Lopes D., Junior O. L. D. S., Lustosa E., Macagnan A. P., Marinho M. C., Mazzoni M., Melo G., Mortari L., Mouco O. M. C. C., Vital C. N., Ormundo C., Emmer S. O., Palmegiani E., Pavani R., Pereira L., Pereira V. L., Perreira R., Poletti S., Fortunato S. C. Q., Queirantes C., Pereira N. R., Rech R. L., Ribeiro S., Rodrigues A., Roesch H., Reichert T. R., Santos D., Santos I., Santos M., Seroqui M. V., Silva S., Soares L., Spolaor L., Stoll C., Duda N. T., Trama L., Unterkircher B., Valois M. V., Vargas T., Viana T., Vicente C., Armaganijan L. V., Homem R. V., Torres L. G. V., Vila L., Filho F. V. G., Eggers G., Gutierrez C. B., Arriagada G., Cardenas S. P., Fernandez B. A. J. S., Conejeros C., Houzvic C., Cuevas P. M., Montecinos H., Forero A., Lanas F., Gomez M. L., Vilches G. C., Rey C., Astudillo C., Aguilar J., Campisto Y., Lara C., Molina E., Oyarzon J. M., Olguin V., Vergara M., Villan C., Diaz J. I., Cantu R. L., Zavala M. G. R., Jardines R. C., Zavaleta N. E., Umana S. V., Rosas E. L., Esperon G. L., Pozas G., Munoz E. C., Hernandez N. M., Rendon A. L., Hernandez N. G., Ibarra M. L. R., Carrillo L. V., Villezca D. L., Herrera C. H., Prieto J. J. L., Rodriguez R. G., Espinosa E. V., Martinez D. F., Barcena J. V., Yong R., Briones I. R., Pons J. L. L., Lopez H. A., Ruiz R. O., de la Vega C. D., Brito C. C., Valenzuela E. C., Reyes-Sanchez R., Ruiz A. B., Flores O. N., Gonzalez M. B., Nava R. A., Cerda J. D. M., Fierro O. F., Campos P. F., Alfaro T. A. A., Bellorin S. A., Avena R., Chavarria M., Espinosa I., Silva F. F., Nava R. H. G., Godoy K., Felix E. J. G., Garcia C. L. G., Salas L. G. G., Guajardo P., Gonzalez S. H., Izquierdo T., Ortiz M. C. M., Vasquez D. M., Mendoza N., Morales J., Nikitina N., Aybar S. O., Ortiz A., Macias P. P., Perez F., Sanchez J. A. P., Toledano S. P., Gonzalez M. R., Ramos C. R., Castro V. 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Y., De Cleen D., De Coninck M., de Vos M., de Weerdt N., Delforge M., Delvigne M., Denie D., Derycker K., Deweerd E., Dormal F., Drieghe S., Everaert M., Eykerman T., Feys E., Ghekiere M., Gits F., Hellemans S., Helvasto L., Jacobs C., Lips S., Mestdagh I., Nimmegeers J., Piamonte V., Pollet P., Postolache A., Raepers M., Raymenants E., Richa J., Rombouts H., Salembier J., Scheurwegs C., Semeraro O., Simons N., Smessaert C., Smolders W., Stockman I., Tahon S., Thyssen V., Tincani G., Van Durme F., Van Lier D., Vandekerckhove H., Vandekerckhove Y., Vandenbroeck D., Vandorpe A., Vanhalst E., Vanhauwaert B., Vantomme C., Vergauwen L., Verloove H., Vydt T., Weyn T., Reichert P., Spacek R., Machova V., Zidkova E., Ludka O., Olsr J., Kotik L., Plocova K., Racz B., Ferkl R., Hubac J., Kotik I., Monhart Z., Burianova H., Jerabek O., Pisova J., Petrova I., Dedek V., Honkova M., Podrazil P., Spinar J., Vitovec J., Novak M., Lastuvka J., Durdil V., Antonova P., Bockova L., Bultas J., Chlumsky J., Dastychova L., Drasnar T., Honek J., Horejsi M., Hubacova V., Janska L., Kopeckova I., Kratochvilova R., Krcova E., Labrova R., Lindourkova A., Lipoldova J., Lubanda H., Ludkova A., Mahdalikova L., Majernikova M., Michalik D., Potuznik P., Prochazkova E., Sulc A., Sveceny J., Valtova M., Zidek M., Zika J., Nielsen H., Husted S., Hintze U., Rasmussen S., Bremmelgaard A., Markenvard J., Boerger J., Solgaard J., Simonsen P., Loekkegaard T., Bruun M., Mertz J., Dominguez H., Skagen K., Egstrup K., Ibsen H., Raymond I., Bang-Hansen T., Ellervik C., Eriksen E., Jensen L., Jensen M., Leth M., Nygaard A., Park J., Schou M., Therkelsen A., Tilma J., Vesterager K., Airaksinen J., Arola O., Koistinen J., Nappila H., Peltomaki K., Rasanen V., Vasankari T., Galinier M., Gottwalles Y., Paganelli F., Loiselet P., Muller J. -J., Koujan M. 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S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. 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M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., El-Aziz, A. A., Seif, S. K. A., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
Subjects: Registrie, Male, Latin Americans, 030204 cardiovascular system & hematology, outcomes, 0302 clinical medicine, Drug Prescription, Retrospective Studie, Risk Factors, Atrial Fibrillation, Antithrombotic, Prospective Studies, Registries, 030212 general & internal medicine, Practice Patterns, Physicians', Stroke, Anticoagulant, Atrial fibrillation, General Medicine, Middle Aged, Treatment Outcome, Stroke prevention, outcome, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, medicine.drug_class, Clinical Investigations, Hemorrhage, antithrombotic treatment, Drug Prescriptions, 03 medical and health sciences, Internal medicine, medicine, Humans, Mexico, Aged, Retrospective Studies, Fibrillation, business.industry, Risk Factor, Anticoagulants, South America, medicine.disease, Drug Utilization, Clinical trial, Prospective Studie, Latin American, antithrombotic treatment, atrial fibrillation, Latin American, outcomes, business
Abstract: Author(s): Jerjes-Sanchez, Carlos; Corbalan, Ramon; Barretto, Antonio CP; Luciardi, Hector L; Allu, Jagan; Illingworth, Laura; Pieper, Karen S; Kayani, Gloria; GARFIELD-AF Investigators | Abstract: BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
Published: 2019

50. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

Author: Dimitrios Farmakiotis, Susie Owenby, Arturo Loaiza-Bonilla, Mansi R. Shah, Matthew Puc, Vadim S. Koshkin, Ahmad Daher, Prakash Peddi, Cameron Rink, Heloisa P. Soares, Eneida R. Nemecek, Mehmet Asim Bilen, Sanjay Mishra, Lidia Schapira, Amit Verma, Ali Raza Khaki, Chih-Yuan Hsu, Sandy DiLullo, Mark Bonnen, Jeanna Knoble, Carla Casulo, Umit Topaloglu, Jorge A. Garcia, Geoffrey Shouse, Praveen Vikas, Clarke A. Low, Archana Ajmera, George D. Demetri, Leyre Zubiri, Grace Glace, Shannon K. McWeeney, Susan Yackzan, Pamela C Egan, Rachel P. Rosovsky, Salvatore Del Prete, Anthony P. Gulati, Lane R. Rosen, Andy Futreal, Merry Jennifer Markham, Sabitha Prabhakaran, Alicia K. Morgans, Sarah Nagle, Lisa Weissmann, Albert C. Yeh, Ziad Bakouny, Stephanie Berg, David Gill, Marcus Messmer, Ryan Nguyen, Terence Duane Rhodes, Vikram M. Narayan, Matthew D. Galsky, Arielle Elkrief, Lori J. Rosenstein, Roy S. Herbst, Justin Shaya, Thorvardur R. Halfdanarson, Douglas B. Johnson, Orestis A. Panagiotou, Sanjay G. Revankar, Toni K. Choueiri, Yu Shyr, Fiona Busser, Kaitlin M. Kelleher, Nicole M. Kuderer, Paul L. Weinstein, Anup Kasi, Grace Shaw, Adam J. Olszewski, Catherine Curran, Samuel M. Rubinstein, Angelo Cabal, Michael H. Bar, John F. Deeken, Vivek Subbiah, Abdul Hai Mansoor, Hina Khan, Rana R. McKay, Catherine Stratton, Saurabh Dahiya, Marc A. Rovito, John Philip, Sanjay Shete, Oscar K. Serrano, Julie Fu, Daniel W. Bowles, Candice Schwartz, Tian Zhang, Pier Vitale Nuzzo, Eric H. Bernicker, Wenxin Xu, Genevieve M. Boland, Sarah Wall, Babar Bashir, Solange Peters, Neeta K. Venepalli, Sandeep H. Mashru, William A. Wood, Anne H. Angevine, Mary F. Mulcahy, Gilberto Lopes, Justin F. Gainor, Jessica Hawley, Monika Joshi, Christopher R. Friese, Navid Hafez, Heather H. Nelson, Gregory J. Riely, Jordan Kharofa, Nilo Azad, Chintan Shah, Gerald Batist, Mary Salazar, Rosemary Zacks, Alice Zhou, Lawrence E. Feldman, Paul Fu, Gary H. Lyman, Nathaniel Bouganim, John A. Steinharter, Shilpa Gupta, Matthias Weiss, Peter Paul Yu, Susan Van Loon, Jamie Stratton, Karen Vega-Luna, Tyler Masters, Christopher Lemmon, Aakash Desai, Bryan A. Faller, Jessica M. Clement, Zhuoer Xie, Keith Stockerl-Goldstein, Corrie A. Painter, Gabrielle Bouchard, Rulla M. Tamimi, Daruka Mahadevan, Rimma Belenkaya, Jill S. Barnholtz-Sloan, Jarushka Naidoo, Amelie G. Ramirez, Philip E. Lammers, Elizabeth A. Griffiths, Michael J. Gurley, X. Li, Jonathan Riess, Syed A. Ahmad, Daniel Blake Flora, Salma K. Jabbour, Jared D. Acoba, Neeraj Agarwal, Ang Li, Sarah Mushtaq, Firas Wehbe, Tanios Bekaii-Saab, Donald C. Vinh, Emily Hsu, Ryan Monahan, Petros Grivas, Harry Menon, John M. Nakayama, Janice M. Mehnert, Elizabeth Marie Wulff-Burchfield, Sara Matar, Paul E. Oberstein, Mary M. Pasquinelli, Axel Grothey, Jack West, John C. Leighton, Dawn L. Hershman, Leslie A. Fecher, Aditya Bardia, Sumit A. Shah, Barbara Logan, Kerry L. Reynolds, Michael A. Thompson, Robert L. Rice, Erin Cook, Trisha Wise-Draper, Christine Bestvina, Daniel Castellano, Paolo Caimi, K. M.Steve Lo, Ruben A. Mesa, Maheen Z. Abidi, Alvaro G. Menendez, Daniel G. Stover, Colleen Lewis, Bertrand Routy, Deborah B. Doroshow, Carmen C. Solorzano, M. Wasif Saif, Rohit Bishnoi, Michael Glover, David D. Chism, Briana Barrow, Christopher McNair, Dimpy P. Shah, Erin A. Gillaspie, Andrea J. Zimmer, Andrew Schmidt, Jessica K. Altman, Michelle Marcum, Rawad Elias, Balazs Halmos, Karen Stauffer, Gayathri Nagaraj, Ardaman Shergill, Mark E. Dailey, Catherine Handy Marshall, Pramod K. Srivastava, Shuchi Gulati, Alokkumar Jha, Mateo Bover Larroya, Mark A. Lewis, Young Soo Rho, James L. Chen, Eli Van Allen, Julie Tsu Yu Wu, Antonio Giordano, Amit Kulkarni, Joerg Rathmann, Donna R. Rivera, Narjust Duma, Maryam B. Lustberg, Theresa M. Carducci, Jeremy L. Warner, Elizabeth Robilotti, Patricia LoRusso, Rohit Jain, Amit Sanyal, Nizar M. Tannir, Kent Hoskins, Nathan A. Pennell, Brian I. Rini, Suki Subbiah, COVID-19 and Cancer Consortium, Abidi, M., Acoba, J.D., Agarwal, N., Ahmad, S., Ajmera, A., Altman, J., Angevine, A.H., Azad, N., Bar, M.H., Bardia, A., Barnholtz-Sloan, J., Barrow, B., Bashir, B., Belenkaya, R., Berg, S., Bernicker, E.H., Bestvina, C., Bishnoi, R., Boland, G., Bonnen, M., Bouchard, G., Bowles, D.W., Busser, F., Cabal, A., Caimi, P., Carducci, T., Casulo, C., Chen, J.L., Clement, J.M., Chism, D., Cook, E., Curran, C., Daher, A., Dailey, M., Dahiya, S., Deeken, J., Demetri, G.D., DiLullo, S., Duma, N., Elias, R., Faller, B., Fecher, L.A., Feldman, L.E., Friese, C.R., Fu, P., Fu, J., Futreal, A., Gainor, J., Garcia, J., Gill, D.M., Gillaspie, E.A., Giordano, A., Glace, M.G., Grothey, A., Gulati, S., Gurley, M., Halmos, B., Herbst, R., Hershman, D., Hoskins, K., Jain, R.K., Jabbour, S., Jha, A., Johnson, D.B., Joshi, M., Kelleher, K., Kharofa, J., Khan, H., Knoble, J., Koshkin, V.S., Kulkarni, A.A., Lammers, P.E., Leighton, J.C., Lewis, M.A., Li, X., Li, A., Lo, KMS, Loaiza-Bonilla, A., LoRusso, P., Low, C.A., Lustberg, M.B., Mahadevan, D., Mansoor, A.H., Marcum, M., Markham, M.J., Handy Marshall, C., Mashru, S.H., Matar, S., McNair, C., McWeeney, S., Mehnert, J.M., Menendez, A., Menon, H., Messmer, M., Monahan, R., Mushtaq, S., Nagaraj, G., Nagle, S., Naidoo, J., Nakayama, J.M., Narayan, V., Nelson, H.H., Nemecek, E.R., Nguyen, R., Nuzzo, P.V., Oberstein, P.E., Olszewski, A.J., Owenby, S., Pasquinelli, M.M., Philip, J., Prabhakaran, S., Puc, M., Ramirez, A., Rathmann, J., Revankar, S.G., Rho, Y.S., Rhodes, T.D., Rice, R.L., Riely, G.J., Riess, J., Rink, C., Robilotti, E.V., Rosenstein, L., Routy, B., Rovito, M.A., Saif, M.W., Sanyal, A., Schapira, L., Schwartz, C., Serrano, O., Shah, M., Shah, C., Shaw, G., Shergill, A., Shouse, G., Soares, H.P., Solorzano, C.C., Srivastava, P.K., Stauffer, K., Stover, D.G., Stratton, J., Stratton, C., Subbiah, V., Tamimi, R., Tannir, N.M., Topaloglu, U., Van Allen, E., Van Loon, S., Vega-Luna, K., Venepalli, N., Verma, A.K., Vikas, P., Wall, S., Weinstein, P.L., Weiss, M., Wise-Draper, T., Wood, W.A., Xu, W.V., Yackzan, S., Zacks, R., Zhang, T., Zimmer, A.J., and West, J.
Subjects: Prognostic variable, medicine.medical_specialty, business.industry, Cancer, General Medicine, Odds ratio, Aged, Antiviral Agents/therapeutic use, Azithromycin/therapeutic use, Betacoronavirus, Cause of Death, Comorbidity, Coronavirus Infections/drug therapy, Coronavirus Infections/epidemiology, Coronavirus Infections/mortality, Databases, Factual, Female, Humans, Hydroxychloroquine/therapeutic use, Male, Middle Aged, Neoplasms/epidemiology, Neoplasms/mortality, Neoplasms/therapy, Pandemics, Pneumonia, Viral/drug therapy, Pneumonia, Viral/epidemiology, Pneumonia, Viral/mortality, Prognosis, Risk Factors, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cohort, Clinical endpoint, Medicine, 030212 general & internal medicine, business, Cause of death, Cohort study
Abstract: Summary Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise the outcomes of a cohort of patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness. Methods In this cohort study, we collected de-identified data on patients with active or previous malignancy, aged 18 years and older, with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from the USA, Canada, and Spain from the COVID-19 and Cancer Consortium (CCC19) database for whom baseline data were added between March 17 and April 16, 2020. We collected data on baseline clinical conditions, medications, cancer diagnosis and treatment, and COVID-19 disease course. The primary endpoint was all-cause mortality within 30 days of diagnosis of COVID-19. We assessed the association between the outcome and potential prognostic variables using logistic regression analyses, partially adjusted for age, sex, smoking status, and obesity. This study is registered with ClinicalTrials.gov, NCT04354701, and is ongoing. Findings Of 1035 records entered into the CCC19 database during the study period, 928 patients met inclusion criteria for our analysis. Median age was 66 years (IQR 57–76), 279 (30%) were aged 75 years or older, and 468 (50%) patients were male. The most prevalent malignancies were breast (191 [21%]) and prostate (152 [16%]). 366 (39%) patients were on active anticancer treatment, and 396 (43%) had active (measurable) cancer. At analysis (May 7, 2020), 121 (13%) patients had died. In logistic regression analysis, independent factors associated with increased 30-day mortality, after partial adjustment, were: increased age (per 10 years; partially adjusted odds ratio 1·84, 95% CI 1·53–2·21), male sex (1·63, 1·07–2·48), smoking status (former smoker vs never smoked: 1·60, 1·03–2·47), number of comorbidities (two vs none: 4·50, 1·33–15·28), Eastern Cooperative Oncology Group performance status of 2 or higher (status of 2 vs 0 or 1: 3·89, 2·11–7·18), active cancer (progressing vs remission: 5·20, 2·77–9·77), and receipt of azithromycin plus hydroxychloroquine (vs treatment with neither: 2·93, 1·79–4·79; confounding by indication cannot be excluded). Compared with residence in the US-Northeast, residence in Canada (0·24, 0·07–0·84) or the US-Midwest (0·50, 0·28–0·90) were associated with decreased 30-day all-cause mortality. Race and ethnicity, obesity status, cancer type, type of anticancer therapy, and recent surgery were not associated with mortality. Interpretation Among patients with cancer and COVID-19, 30-day all-cause mortality was high and associated with general risk factors and risk factors unique to patients with cancer. Longer follow-up is needed to better understand the effect of COVID-19 on outcomes in patients with cancer, including the ability to continue specific cancer treatments. Funding American Cancer Society, National Institutes of Health, and Hope Foundation for Cancer Research.
Published: 2020

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