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With the interventions of globalization, the human race is lagging behind in its health management. Some of the major health risks involved are cardiac arrest, loss of sleep, lack of concentration, regular muscular pain, arthritis, etc. Arthritis and its various forms lead to regular joint pain and are hampering the daily lives of human beings. Garlic is reported to be one of the best natural medicines for arthritis. The pungency of garlic is due to its various sulfur compounds. Studies have been carried out in determining the effect of these sulfur compounds as antiinflammatory compounds and their role in the signaling pathways of arthritis. Also, there is a scope for advanced level research such as incorporation of nanotechnology and biotechnology for exploiting the potential of this wonder drug garlic for the treatment of arthritis.

The advent of new drugs has resulted in cures for many neural, cancerous, muscular, musculoskeletal, cardiac, and pulmonary diseases that were found incurable in earlier times. Still, from ancient times through today, natural products have been seen as the best way to cure diseases. On the same path, for many decades curcumin has been reported as an alternative cure for various diseases, the major one being arthritis. In this chapter, we have compiled and discussed the potential and prospect of curcumin in alleviating arthritis. The promising results of curcumin's effect on arthritis signaling pathways have been experimentally proved on various natural and induced animal models, paving the way for clinical trials and finally reaching patients. The incorporation of nanotechnology with curcumin administration has increased both the bioavailability and absorption into the patient's body. Curcumin's derivatives and analogs also seem to play a vital role in strengthening the backbone of arthritis treatment.