Author: "Stadler A" / Topic: medicine.disease - Searchworks@Jio Institute Digital Library Search Results

1,781 results on '"Stadler A"'

1. Factors Influencing Patient Preferences for Telehealth Cancer Genetic Counseling During the COVID-19 Pandemic

Author: Margaret Sheehan, Kelsey Breen, David Wylie, Zsofia K. Stadler, Erin E. Salo-Mullen, Malwina Tuman, Jada G. Hamilton, Megan Harlan Fleischut, Kenneth Offit, and Corinna Bertelsen
Subjects: Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Genetic counseling, education, Genetic Counseling, Telehealth, ORIGINAL CONTRIBUTIONS, Neoplasms, Pandemic, Health care, medicine, Humans, Pandemics, health care economics and organizations, Aged, SARS-CoV-2, Oncology (nursing), business.industry, Health Policy, COVID-19, Cancer, Patient Preference, Middle Aged, medicine.disease, Patient preference, Telemedicine, Oncology, Family medicine, Female, business
Abstract: PURPOSE: With onset of the COVID-19 pandemic, telehealth became the primary modality for health care appointments. This study examined patient experiences with and preferences for telehealth at a cancer genetic counseling clinic throughout the first 6 months of the pandemic (March-August 2020). METHODS: An anonymous survey assessed patient demographics; usage and prior experience with technology; emotional responses, technical experiences, and satisfaction with the telehealth appointment (via the Genetic Counseling Satisfaction Scale and Visit-Specific Satisfaction Questionnaire); preference for future telehealth; and recommendation of telehealth to others. RESULTS: Among 380 respondents, most were highly satisfied with the telehealth appointment (with 65.6% and 66.4% of participants completing the Genetic Counseling Satisfaction Scale and Visit-Specific Satisfaction Questionnaire, respectively). Multivariable analyses indicated several notable findings. Adjusting for relevant covariates, participants with less education felt significantly more concerned about telehealth than those with highest educational attainment. Participants age 40-69 years were generally more comfortable, relieved, and grateful that their appointment was scheduled as telehealth than were those older than 70 years. Women were marginally more relieved and grateful for telehealth appointments than men. As the pandemic progressed, significantly more participants were highly satisfied with their telehealth appointment and participants trended toward having greater preferences for future telehealth use. Most participants (78.6%) would recommend telehealth to others, although 50.8% preferred future in-person appointments. CONCLUSION: As the pandemic progressed, patients expressed increasing preferences for and satisfaction with telehealth. Service delivery models that incorporate individual patient preferences should be developed with special consideration to factors such as age, sex, and education level.
Published: 2022

2. Using pharmacy technicians and electronic health record capabilities to improve outcomes for patients with cardiovascular disease

Author: Cari R. Friesleben, Stephanie M. Campbell, Jessica M. Stine, Jennifer J. Schimmer, Kari L. Olson, Jessica Angleson, and Sheila L. Stadler
Subjects: Male, medicine.medical_specialty, Pharmacy Technicians, Pharmacology (nursing), Pharmacy, Diabetes mellitus, medicine, Electronic Health Records, Humans, media_common.cataloged_instance, Aged, Retrospective Studies, media_common, Aged, 80 and over, Pharmacology, business.industry, Retrospective cohort study, Cholesterol, LDL, Middle Aged, medicine.disease, Clinical pharmacy, Blood pressure, Cardiovascular Diseases, Emergency medicine, Ambulatory, Female, business, Pharmacy technician, Dyslipidemia
Abstract: OBJECTIVE This study aimed to compare lipid and blood pressure (BP) control before and after implementing a certified pharmacy technician (CPhT) protocol that optimized electronic health record (EHR) capabilities and shifted work from clinical pharmacy specialists (CPSs) to CPhT. SETTING Kaiser Permanente Colorado's pharmacist-managed cardiac risk reduction service (which manages dyslipidemia, hypertension, and diabetes for all patients with atherosclerotic cardiovascular disease). PRACTICE DESCRIPTION In 2019, a protocol that optimized EHR capabilities and allowed work to be offloaded from CPS to CPhT was implemented. Filtered views within the EHR were created that bucketed patients with specific lipid results criteria. The CPhT protocol provided guidance to CPhT on determining whether patients were at low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein (non-HDL) goals, on appropriate statin intensity, adherent to medications, and whether the most recent BP was controlled. The CPhT notified CPS of uncontrolled patients who would assess and manage these patients, as necessary. The CPhT notified controlled patients of their results. PRACTICE INNOVATION Data on the outcomes of incorporating pharmacy technicians to support CPS clinical activities in ambulatory clinical pharmacy are limited. EVALUATION METHODS This retrospective study compared a "Pharmacist-Driven" (index date: January 1, 2016) with a "Tech-Enhanced" (index date: January 1, 2019) group. The primary outcome was the proportion of patients at all goals defined as LDL-C < 70 mg/dL, non-HDL
Published: 2022

3. Risk-Reducing Bilateral Salpingo-Oophorectomy for Ovarian Cancer: A Review and Clinical Guide for Hereditary Predisposition Genes

Author: Kelsey Breen, Zsofia K. Stadler, Rachel N. Grisham, Kara Long Roche, Deborah J. Goldfrank, Melissa K. Frey, Alicia Latham, Ying L Liu, Carol Aghajanian, Amanda Catchings, Dennis S. Chi, Kenneth Offit, Megha Ranganathan, and Nadeem R. Abu-Rustum
Subjects: Oncology, medicine.medical_specialty, Oncology (nursing), business.industry, Health Policy, medicine.disease, Bilateral salpingo-oophorectomy, Germline, Internal medicine, medicine, Ovarian cancer, business, Gene
Abstract: Pathogenic germline variants underlie up to 20% of ovarian cancer (OC) and are associated with varying degrees of risk for OC. For mutations in high-penetrance genes such as BRCA1/ 2, the role of risk-reducing bilateral salpingo-oophorectomy (RRSO) in cancer prevention is well-established and improves mortality. However, in moderate-penetrance genes where the degree of risk for OC is less precisely defined, the role of RRSO is more controversial. Although national guidelines have evolved to incorporate gene-specific recommendations, studies demonstrate significant variations in practice. Given this, our multidisciplinary group has reviewed the available literature on risk estimates for genes associated with OC, incorporated levels of evidence, and set thresholds for consideration of RRSO. We found that the benefit of RRSO is well-established for pathogenic variants in BRCA1/2 as well as BRIP1 and RAD51C/ D where the risk of OC is elevated beyond our threshold for RRSO. In PALB2, RRSO is particularly controversial as newer studies consistently demonstrate an increased risk of OC that is dependent on family history, making uniform recommendations challenging. Additionally, new guidelines for Lynch syndrome provide gene-specific risks, questioning the role of RRSO, and even hysterectomy, for MSH6 and PMS2 mutation carriers. Given these uncertainties, shared decision making should be used around RRSO with discussion of individual risk factors, family history, and adverse effects of surgery and premature menopause. Herein, we provide a clinical guide and counseling points.
Published: 2022

4. Safety and Quality in Syndromic Neurosurgery

Author: James A Stadler and Mari L. Groves
Subjects: medicine.medical_specialty, business.industry, Communication, media_common.quotation_subject, Neurosurgery, Quality care, General Medicine, Multidisciplinary team, medicine.disease, Quality Improvement, Patient safety, medicine, Humans, Surgery, Quality (business), Neurology (clinical), Medical emergency, Open communication, business, Health care quality, media_common
Abstract: The developing field of syndromic neurosurgery has significant challenges and opportunities in quality and safety. Quality care must be safe, effective, patient-centered, timely, efficient, and equitable; the Donabedian model focused on system structures, processes, and outcomes is a helpful framework to guide improvement in these areas. Ultimately, a successful syndromic neurosurgery program will bring together an interested multidisciplinary team of experts who will grow care through open communication and steady improvement efforts.
Published: 2022

5. Cerebrospinal Fluid Penetration of Vancomycin During Continuous Infusion Therapy in Patients With Nosocomial Ventriculitis

Author: João Paulo Telles, Felipe Francisco Tuon, Victoria Stadler Tasca Ribeiro, Carolina Hikari Yamada, Juliano Gasparetto, Juliette Cieslinski, and Dayana Dos Santos Oliveira
Subjects: Pharmacology, Cross Infection, medicine.medical_specialty, Maintenance dose, business.industry, Area under the curve, Renal function, medicine.disease, Gastroenterology, Loading dose, Anti-Bacterial Agents, Cerebral Ventriculitis, Intensive Care Units, Vancomycin, Internal medicine, medicine, Ventriculitis, Humans, Cerebrospinal fluid penetration, Pharmacology (medical), business, External ventricular drain, medicine.drug
Abstract: Background This study aimed to evaluate the utility of a commercial kit used to measure serum vancomycin concentrations to determine vancomycin concentrations in cerebrospinal fluid (CSF) samples and evaluate CSF penetration when administered as a continuous high-dose infusion in patients with nosocomial ventriculitis. Methods This study included patients with external ventricular drain infection who were admitted to the intensive care unit between January 2018 and September 2020. After validation, CSF samples from 33 patients were collected. All patients received 30 mg/kg of vancomycin as a loading dose followed by 60 mg/kg as a maintenance dose in continuous infusion; all CSF samples were collected at least 48 hours after the first dose. Results Thirty-three patients were enrolled in this study. The median serum creatinine level was 0.66 mg/dL (0.5-0.92; n = 30), and median creatinine clearance was 119.2 mL/min (64.6-138.4; n = 13). The median serum vancomycin 24-hour area under the curve (AUC24h) was 838 mg*h/L (515-1010). The median CSF vancomycin concentration was 5.20 mg/L (1.95-12.4). Median serum vancomycin concentration was 34.9 mg/L (21.47-42.1), and median CSF/serum ratio was 18.6% (8.4-41.5). Acute renal injury occurred in 21% (n = 7) of the patients by the end of the therapy. In addition, the vancomycin CSF/serum ratio was positively correlated with the median serum creatinine level (r = 0.670; P = 0.004). Conclusions Commercial vancomycin kits used to measure serum samples may be used to evaluate vancomycin concentrations in the CSF. Vancomycin penetration into CSF was 18.6%.
Published: 2021

6. Comparison of out-of-pocket costs and adherence between the two arms of the prospective, randomized abiraterone food effect trial

Author: Alvin Wong, Daniel M. Geynisman, Brian L. Heiss, Elia Martinez, Wei Peng Yong, Walter M. Stadler, and Russell Z. Szmulewitz
Subjects: Male, medicine.medical_specialty, Article, law.invention, chemistry.chemical_compound, Prostate cancer, Randomized controlled trial, law, Internal medicine, medicine, Humans, Prospective Studies, Trial registration, FOOD EFFECT, Meal, business.industry, Abiraterone acetate, medicine.disease, Prostatic Neoplasms, Castration-Resistant, Abiraterone, Oncology, chemistry, Androstenes, Health Expenditures, business, Enhanced absorption
Abstract: Purpose Abiraterone acetate, prescribed for metastatic prostate cancer, has enhanced absorption with food. This effect was exploited in a randomized trial which showed noninferiority of PSA decline for 250 mg abiraterone with a low-fat meal (LOW) compared to 1,000 mg abiraterone fasting (STD). Drug was obtained via patient insurance. Patient out-of-pocket costs and adherence were surveyed. Methods Trial participants were randomized to STD or LOW, and surveys of adherence and out-of-pocket costs were administered at baseline and just before coming off study (follow-up). Results Out-of-pocket costs were available from 20 of 36 STD and 21 of 36 LOW patients. Median out-of-pocket costs for a month of drug were $0 (LOW) and $5 (STD); mean costs were $43.61 (LOW) and $393.83 (STD). The two groups did not differ significantly (p = 0.421). Maximum out-of-pocket cost was $1,000 (LOW) and $4,000 (STD). Monthly out-of-pocket costs > $500 were found in 1 LOW and 5 STD patients. For adherence, only 11 STD and 19 LOW patients had questionnaires completed at both baseline and follow-up. STD adherence was 98.18% at baseline and 91.69% at follow-up, differing significantly (p = 0.0078). LOW adherence was 96.52% at baseline and 97.86% at follow-up, not differing significantly (p = 0.3511). Adherence did not correlate with demographics. At follow-up, increasing adherence correlated significantly with decreasing dose (p = 0.013; rho = - 0.458). Conclusions Out-of-pocket costs did not differ significantly in this limited analysis. Adherence was significantly different in STD as the trial progressed, which was not found in LOW. Trial registration ClinicalTrials.gov NCT01543776; registered March 5, 2012.
Published: 2021

7. Current and Future Clinical Applications of ctDNA in Immuno-Oncology

Author: Klaus Pantel, Isabel Heidrich, Julia Christina Stadler, Benjamin Deitert, Yassine Belloum, Laura Keller, Mark Sementsov, and Christoffer Gebhardt
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, business.industry, Surrogate endpoint, medicine.medical_treatment, Melanoma, Cancer, Immunotherapy, medicine.disease, Circulating Tumor DNA, Clinical trial, Cancer immunotherapy, Internal medicine, Biomarkers, Tumor, medicine, Humans, Biomarker (medicine), business
Abstract: Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive opportunity to diagnose, characterize, and monitor the disease in individual cancer patients. ctDNA can reflect the actual tumor burden and specific genomic state of disease and thus might serve as a prognostic and predictive biomarker for immune checkpoint inhibitor (ICI) therapy. Recent studies in various cancer entities (e.g., melanoma, non–small cell lung cancer, colon cancer, and urothelial cancer) have shown that sequential ctDNA analyses allow for the identification of responders to ICI therapy, with a significant lead time to imaging. ctDNA assessment may also help distinguish pseudoprogression under ICI therapy from real progression. Developing dynamic changes in ctDNA concentrations as a potential surrogate endpoint of clinical efficacy in patients undergoing adjuvant immunotherapy is ongoing. Besides overall ctDNA burden, further ctDNA characterization can help uncover tumor-specific determinants (e.g., tumor mutational burden and microsatellite instability) of responses or resistance to immunotherapy. In future studies, standardized ctDNA assessments need to be included in interventional clinical trials across cancer entities to demonstrate the clinical utility of ctDNA as a biomarker for personalized cancer immunotherapy.
Published: 2021

8. Terrestrial connectivity, upstream aquatic history and seasonality shape bacterial community assembly within a large boreal aquatic network

Author: Paul A. del Giorgio and M. Stadler
Subjects: 0106 biological sciences, 0303 health sciences, Ecology, Limnology, Ecological succession, 15. Life on land, Seasonality, Biology, medicine.disease, 010603 evolutionary biology, 01 natural sciences, Microbiology, 03 medical and health sciences, Taxon, Microbial population biology, Microbial ecology, Boreal, Soil water, medicine, 14. Life underwater, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology
Abstract: During transit from soils to the ocean, microbial communities are modified and re-assembled, generating complex patterns of ecological succession. The potential effect of upstream assembly on downstream microbial community composition is seldom considered within aquatic networks. Here, we reconstructed the microbial succession along a land-freshwater-estuary continuum within La Romaine river watershed in Northeastern Canada. We captured hydrological seasonality and differentiated the total and reactive community by sequencing both 16 S rRNA genes and transcripts. By examining how DNA- and RNA-based assemblages diverge and converge along the continuum, we inferred temporal shifts in the relative importance of assembly processes, with mass effects dominant in spring, and species selection becoming stronger in summer. The location of strongest selection within the network differed between seasons, suggesting that selection hotspots shift depending on hydrological conditions. The unreactive fraction (no/minor RNA contribution) was composed of taxa with diverse potential origins along the whole aquatic network, while the majority of the reactive pool (major RNA contribution) could be traced to soil/soilwater-derived taxa, which were distributed along the entire rank-abundance curve. Overall, our findings highlight the importance of considering upstream history, hydrological seasonality and the reactive microbial fraction to fully understand microbial community assembly on a network scale.
Published: 2021

9. Uptake and acceptability of a mainstreaming model of hereditary cancer multigene panel testing among patients with ovarian, pancreatic, and prostate cancer

Author: Anna Arutyunova, Maria I. Carlo, Jada G. Hamilton, Rebecca Gebert, Mark E. Robson, Erin E. Salo-Mullen, Vivek Narayan, Melissa Batson, Heather Symecko, Kelsey Spielman, Amanda Catchings, Zsofia K. Stadler, Ibrahim H Shah, Stacy Pundock, Elizabeth Schofield, Susan M. Domchek, Kenneth Offit, Karen Cadoo, Rebecca Mueller, Kelsey Breen, Magan Trottier, and Kim A. Reiss
Subjects: Male, medicine.medical_specialty, Genetic counseling, MEDLINE, Genetic Counseling, Mainstreaming, Article, treatment-focused genetic testing, Prostate cancer, multigene panel testing, psychosocial outcomes, Internal medicine, Humans, Medicine, Genetic Predisposition to Disease, Genetic Testing, Prospective Studies, Genetics (clinical), Depression (differential diagnoses), Genetic testing, medicine.diagnostic_test, business.industry, Prostatic Neoplasms, medicine.disease, Distress, hereditary cancer, business, Patient education
Abstract: Purpose: To address demands for timely germline information to guide treatments, we evaluated experiences of patients with ovarian, pancreatic, and prostate cancer with a mainstreaming genetic testing model wherein multigene panel testing was ordered by oncologists with standardized pre-test patient education, and genetic counselors delivered results and post-test genetic counseling via telephone. Methods: Among 1203 eligible patients, we conducted a prospective single-arm study to examine patient uptake and acceptability (via self-report surveys at baseline and three-weeks and three-months following result return) of this mainstreaming model. Results: Only 10% of eligible patients declined participation. Among 1054 tested participants, 10% had pathogenic variants (PV), 16% had variants of uncertain significance (VUS), and 74% had no variant identified (NV). Participants reported high initial acceptability, including high satisfaction with their testing decision. Variability over time in several outcomes existed for participants with PV or NV: Those with NV experienced a temporary increase in depression (pTime
Published: 2021

10. T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice

Author: Wen-Min Chou, Daniela Stadler, Jochen M. Wettengel, Chunkyu Ko, Shanshan Luo, Elfriede Noeßner, Ulrike Protzer, Jan Hendrik Bockmann, Zhe Xie, Lili Zhao, Oliver Quitt, Nadja Bulbuc, Forough Golsaz-Shirazi, Gerhard Moldenhauer, Julia Festag, Raindy Tedjokusumo, Mathias Heikenwalder, Felix Bohne, Frank Momburg, Eva Loffredo-Verde, Marten Meyer, Sandra Lüttgau, and Fazel Shokri
Subjects: Hepatitis B virus, HBsAg, T-Lymphocytes, medicine.medical_treatment, T cell, medicine.disease_cause, Statistics, Nonparametric, Hepatitis B Antigens, Bispecific T-cell Engager, Immunotherapy, T-cell Redirection, Viral Hepatitis, Mice, medicine, Animals, Cytotoxic T cell, Hepatology, business.industry, virus diseases, CD28, Flow Cytometry, Hepatitis B, Acquired immune system, medicine.disease, digestive system diseases, Disease Models, Animal, medicine.anatomical_structure, Cancer research, business, Viral hepatitis
Abstract: BACKGROUND & AIMS: Hepatitis B virus (HBV) infection is a global health threat responsible for 880,000 deaths per year. Current antiviral therapies control but rarely eliminate the virus, and leave chronic HBV carriers at risk to develop hepatocellular carcinoma (HCC). Lacking or dysfunctional virus-specific adaptive immunity prevents control of HBV and allows the virus to persist. Restoring anti-viral T-cell immunity to achieve HBV elimination in chronically infected patients will help to cure HBV. METHODS: We constructed bispecific T-cell engager antibodies that are designed to induce anti-viral immunity through simultaneous binding of HBV envelope proteins (HBVenv) on infected hepatocytes and cluster of differentiation 3 or 28 on T cells. T-cell engager antibodies were employed in co-cultures with healthy donor lymphocytes and HBV-infected target cells. Activation of T-cell response was determined by detection of pro-inflammatory cytokines, effector function by cytotoxicity and antiviral effects. To study in vivo efficacy, immune-deficient mice were transplanted with HBV envelope-positive and -negative hepatoma cells. RESULTS: The two T-cell engager antibodies synergistically activated T cells to become polyfunctional effectors that in turn elicited potent anti-viral effects by killing infected cells and in addition controlled HBV via non-cytolytic, cytokine-mediated antiviral mechanisms. In vivo in mice, the antibodies attracted T cells specifically to the tumors expressing HBVenv resulting in T-cell activation, tumor infiltration and reduction of tumor burden. CONCLUSION: This study demonstrates that the administration of HBVenv-targeting T-cell engager antibodies facilitates a robust T-cell redirection towards HBV-positive target cells and provides a feasible and promising approach for the treatment of chronic viral hepatitis and HBV-associated HCC. LAY SUMMARY: T-cell engager antibodies are an interesting, novel therapeutic tool to restore immunity in patients with chronic hepatitis B. As bispecific antibodies they on the hand bind HBV envelope proteins displayed on the surface of HBV-infected cells or HBV-positive hepatoma and on the other hand attract and stimulate T cells by binding CD3 or CD28 on the T cell. Hereby, they activate a potent antiviral and cytotoxic response resulting in the elimination of HBV-positive cells. Their potential to activate T cells to resolve HBV infection renders T-cell engagers interesting candidates for the therapy of chronic hepatitis B and HBV-associated hepatocellular carcinoma.
Published: 2021

11. The context-specific role of germline pathogenicity in tumorigenesis

Author: Marc Ladanyi, Gowtham Jayakumaran, Karen Cadoo, Ahmet Zehir, Philip Jonsson, Xiang Li, Jason Hwee, Meera Prasad, Michael Walsh, Jinru Shia, Allison Richards, Alexander V Penson, Aijazuddin Syed, Joseph Vijai, Roy Cambria, Michael F. Berger, Barry S. Taylor, Mark E. Robson, Semanti Mukherjee, Chaitanya Bandlamudi, Jianjiong Gao, Christopher J. Fong, Ozge Ceyhan-Birsoy, Maria I. Carlo, Liying Zhang, David M. Hyman, Preethi Srinivasan, Ino de Bruijn, Diana Mandelker, Jesse Galle, Selcuk Onur Sumer, Craig M. Bielski, Kenneth Offit, Shweta S. Chavan, Nikolaus Schultz, Yelena Kemel, David B. Solit, and Zsofia K. Stadler
Subjects: Heterozygote, DNA Copy Number Variations, Carcinogenesis, Somatic cell, Biology, medicine.disease_cause, DNA Mismatch Repair, Medical and Health Sciences, Germline, Rare Diseases, Clinical Research, Neoplasms, Genetics, medicine, Humans, 2.1 Biological and endogenous factors, Genetic Predisposition to Disease, Aetiology, Allele, Gene, Germ-Line Mutation, Cancer, Human Genome, Biological Sciences, medicine.disease, Phenotype, Penetrance, Developmental Biology
Abstract: Human cancers arise from environmental, heritable and somatic factors, but how these mechanisms interact in tumorigenesis is poorly understood. Studying 17,152 prospectively sequenced patients with cancer, we identified pathogenic germline variants in cancer predisposition genes, and assessed their zygosity and co-occurring somatic alterations in the concomitant tumors. Two major routes to tumorigenesis were apparent. In carriers of pathogenic germline variants in high-penetrance genes (5.1% overall), lineage-dependent patterns of biallelic inactivation led to tumors exhibiting mechanism-specific somatic phenotypes and fewer additional somatic oncogenic drivers. Nevertheless, 27% of cancers in these patients, and most tumors in patients with pathogenic germline variants in lower-penetrance genes, lacked particular hallmarks of tumorigenesis associated with the germline allele. The dependence of tumors on pathogenic germline variants is variable and often dictated by both penetrance and lineage, a finding with implications for clinical management. A study of 17,152 patients with cancer identified pathogenic germline variants in cancer predisposition genes. Although tumors showed biallelic inactivation for high-penetrance genes, this was not the case in most patients with pathogenic variants in low-penetrance genes, suggesting alternative routes to tumorigenesis.
Published: 2021

12. Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer

Author: Jinru Shia, Chin-Tung Chen, Martin R. Weiser, Karuna Ganesh, Chad M. Vanderbilt, Neil H. Segal, Canan Firat, Ajaratu Keshinro, Zsofia K. Stadler, Jin K Kim, Mithat Gonen, and Rona Yaeger
Subjects: 0301 basic medicine, Cancer Research, POLD1, Tumor-infiltrating lymphocytes, Colorectal cancer, Mutant, Biology, medicine.disease, digestive system diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, Microsatellite Stable, 030220 oncology & carcinogenesis, Cancer research, medicine, Microsatellite
Abstract: PURPOSE To characterize the relationship between tumor-infiltrating lymphocytes (TIL), tumor mutational burden (TMB), and genetic alterations in microsatellite stable (MSS), microsatellite instability (MSI), or mutant POLE/POLD1 colon cancer. MATERIALS AND METHODS Four hundred ninety-nine resected stage I-III colon tumors treated between 2014 and 2019 were assessed for TIL; somatic mutations, copy number alterations, and structural changes in > 400 oncogenes; and MSI status. RESULTS Of the 499 tumors analyzed, 313 were MSS, 175 were MSI, and 11 had POLE/POLD1 pathogenic mutations. Both the percentage of tumors with a high level of TIL (≥ 4 lymphocytes per high-power field) and the median TMB differed significantly between the three phenotypes: MSS, 4.5% and 6 mutations/Mb; MSI, 68% and 54 mutations/Mb; POLE/POLD1, 82% and 158 mutations/Mb ( P < .05). Within each phenotype, TMB did not vary significantly with TIL level. Among MSI tumors, the median number of frameshift indels was significantly higher in tumors with high levels of TIL (20 v 17; P = .018). In the MSS group, significantly higher proportions of tumors with high levels of TIL had mutations in the transforming growth factor-β (36% v 12%; P = .01), RAS (86% v 54%; P = .02), and Hippo (7% v 1%; P = .046) pathways; in contrast, TP53 alterations were associated with low levels of TIL (74% v 43%; P = .01). CONCLUSION The association between TIL, TMB, and genetic alterations varies significantly between MSI, MSS, and mutant POLE/POLD1 colon tumors. These differences may help explain tumoral immunity and lead to predictors of response to immunotherapy.
Published: 2021

13. Tolerability of Breast Radiotherapy Among Carriers of ATM Germline Variants

Author: Mark E. Robson, Boris Mueller, Zsofia K. Stadler, Beryl McCormick, Erin F. Gillespie, Lior Z. Braunstein, Simon N. Powell, Jessica Flynn, Zhigang Zhang, Oren Cahlon, Leslie A. Modlin, and Atif J. Khan
Subjects: Adult, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Breast Neoplasms, Breast radiotherapy, Ataxia Telangiectasia Mutated Proteins, Germline, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Text mining, Internal medicine, medicine, Humans, Gene, Aged, Retrospective Studies, business.industry, Genetic Variation, ORIGINAL REPORTS, Middle Aged, medicine.disease, Germ Cells, 030104 developmental biology, Tolerability, 030220 oncology & carcinogenesis, Female, Lifetime risk, business
Abstract: PURPOSE ATM, a gene that controls repair of DNA double-strand breaks, confers an excess lifetime risk of breast cancer among carriers of germline pathogenic variants (PV). ATM PV homozygotes are particularly sensitive to DNA damage caused by ionizing radiation. Consequently, there is concern that adjuvant radiotherapy (RT) may cause excess morbidity among heterozygous carriers of ATM PV. We evaluated the tolerability of breast RT among carriers of ATM germline variants. METHODS Of 167 patients with ATM germline variants presenting to our institution with breast cancer, 91 received RT. Treatment-related toxicity was ascertained from medical records and graded across organ systems. Toxicities grade > 2 were recorded from the end of treatment to last evaluable follow-up and were analyzed according to ATM variant pathogenicity. RESULTS Of 91 evaluable carriers of ATM variants, with a median follow-up of 32 months following RT, 25% (n = 23) harbored a PV, whereas 75% (n = 68) harbored a variant of uncertain significance (VUS). Prevalence of grade ≥ 2 toxicity unrelated to post-mastectomy reconstruction among patients with ATM PV was: 32% at the end of treatment ( v 34% for VUS carriers), 11% at 1 year of follow-up ( v 4% for VUS carriers), and 8% at the last follow-up ( v 13% for VUS carriers), consistent with previous studies of RT among unselected populations. No grade 4 or 5 toxicities were observed. ATM variant pathogenicity was not associated with local toxicity, contralateral breast cancer, or secondary malignancy in this limited cohort of patients who received breast RT. CONCLUSION We found no evidence of excess RT-associated toxicity among carriers of pathogenic ATM germline variants. Breast-conserving therapy and adjuvant RT may be safely considered among appropriately selected carriers of ATM germline variants.
Published: 2021

14. Prevalence and Characterization of Biallelic and Monoallelic NTHL1 and MSH3 Variant Carriers From a Pan-Cancer Patient Population

Author: David B. Solit, Angela G. Arnold, Mark E. Robson, Diana Mandelker, Michael F. Berger, Shweta S. Chavan, Maksym Misyura, Michael Walsh, Anna Maio, Sarah R. Kane, Karen Cadoo, Yelena Kemel, Preethi Srinivasan, Ying Liu, Jinru Shia, Kenneth Offit, Kelsey Breen, Jennifer Kennedy, Margaret Sheehan, Semanti Mukherjee, Caitlin Bourque, Chaitanya Bandlamudi, Zalak Patel, Maria I. Carlo, Zsofia K. Stadler, Amanda Catchings, Erin E. Salo-Mullen, Arnold J. Markowitz, Barry S. Taylor, Prince Rainier Tejada, Rosalba Sacca, Vanessa Marcell, Alicia Latham, Ozge Ceyhan-Birsoy, Mark T.A. Donoghue, Kimberly Amoroso, and Megha Ranganathan
Subjects: 0301 basic medicine, Genetics, Cancer Research, Pan cancer, business.industry, Cancer predisposition, Cancer, medicine.disease, 03 medical and health sciences, Patient population, 030104 developmental biology, 0302 clinical medicine, Oncology, MSH3, 030220 oncology & carcinogenesis, medicine, business, Gene
Abstract: PURPOSE NTHL1 and MSH3 have been implicated as autosomal recessive cancer predisposition genes. Although individuals with biallelic NTHL1 and MSH3 pathogenic variants (PVs) have increased cancer and polyposis risk, risks for monoallelic carriers are uncertain. We sought to assess the prevalence and characterize NTHL1 and MSH3 from a large pan-cancer patient population. MATERIALS AND METHODS Patients with pan-cancer (n = 11,081) underwent matched tumor-normal sequencing with consent for germline analysis. Medical records and tumors were reviewed and analyzed. Prevalence of PVs was compared with reference controls (Genome Aggregation Database). RESULTS NTHL1-PVs were identified in 40 patients including 39 monoallelic carriers (39/11,081 = 0.35%) and one with biallelic variants (1/11,081 = 0.009%) and a diagnosis of isolated early-onset breast cancer. NTHL1-associated mutational signature 30 was identified in the tumors of the biallelic patient and two carriers. Colonic polyposis was not identified in any NTHL1 patient. MSH3-PVs were identified in 13 patients, including 12 monoallelic carriers (12/11,081 = 0.11%) and one with biallelic MSH3 variants (1/11,081 = 0.009%) and diagnoses of later-onset cancers, attenuated polyposis, and abnormal MSH3-protein expression. Of the 12 MSH3 carriers, two had early-onset cancer diagnoses with tumor loss of heterozygosity of the wild-type MSH3 allele. Ancestry-specific burden tests demonstrated that NTHL1 and MSH3 prevalence was not significantly different in this pan-cancer population versus controls. CONCLUSION NTHL1 and MSH3 germline alterations were not enriched in this pan-cancer patient population. However, tumor-specific findings, such as mutational signature 30 and loss of heterozygosity of the wild-type allele, suggest the potential contribution of monoallelic variants to tumorigenesis in a subset of patients.
Published: 2021

15. Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Author: Olukayode Arowolo, Jeremy Constable, David E. Ibikunle, Mithat Gonen, SA Olatoke, Yelena Kemel, Olalekan Olasehinde, Olusola A. Adesiyun, Jinru Shia, Nikolaus Schultz, Olaejinrinde O. Olaofe, J. Joshua Smith, Michael F. Berger, David B. Solit, SO Agodirin, Akinwumi O. Komolafe, Azfar Basunia, Walid K. Chatila, T. Peter Kingham, Ronak Shah, Kenneth Seier, Murray F. Brennan, Kanika Arora, Gregory C. Knapp, Timothy A. Chan, Francisco Sanchez-Vega, Martin R. Weiser, Olusegun I. Alatise, Brooke E. Sylvester, Aba Katung, Efsevia Vakiani, O C Famurewa, Oladapo Adedayo Kolawole, Akinwumi O. Olakanmi, Ademola Adeyeye, Zsofia K. Stadler, Avinash Sharma, Adeleye D. Omisore, Adedeji A. Egberongbe, and Chao Wu
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Lung Neoplasms, Adolescent, Colorectal cancer, Science, Nigeria, General Physics and Astronomy, Early detection, Article, General Biochemistry, Genetics and Molecular Biology, West africa, Young Adult, Risk Factors, Cancer genome, Internal medicine, Biomarkers, Tumor, medicine, Humans, Cancer genetics, neoplasms, Peritoneal Neoplasms, Aged, Aged, 80 and over, Multidisciplinary, business.industry, Liver Neoplasms, Age Factors, High-Throughput Nucleotide Sequencing, Cancer, Microsatellite instability, General Chemistry, Middle Aged, medicine.disease, Phenotype, digestive system diseases, Case-Control Studies, Mutation, Female, Microsatellite Instability, Colorectal Neoplasms, business, Rectal disease
Abstract: Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P, Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is important for early detection and treatment. Here, the authors use a multigene next-generation sequencing panel to identify genomic differences in Nigerian CRCs compared to those from TCGA and MSKCC cohorts.
Published: 2021

16. Effectiveness of a surveillance program of upper endoscopy for upper gastrointestinal cancers in Lynch syndrome patients

Author: Zsofia K. Stadler, Hans Gerdes, Robin B. Mendelsohn, Jinru Shia, Mark A. Schattner, Janie J. Yang, Mengmeng Du, Elizabeth D. Kantor, Arnold J. Markowitz, Joe Mermelstein, Emmy Ludwig, Delia Calo, Alicia Latham, and Amanda H. Ceravolo
Subjects: medicine.medical_specialty, Colorectal cancer, Gastroenterology, Article, Endoscopy, Gastrointestinal, Stomach Neoplasms, Internal medicine, Gastroscopy, medicine, Humans, Endoscopy, Digestive System, Gastrointestinal Neoplasms, Retrospective Studies, medicine.diagnostic_test, business.industry, Esophagogastroduodenoscopy, Cancer, Middle Aged, Hepatology, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, Lynch syndrome, Cohort, Duodenal adenocarcinoma, Duodenal cancer, business
Abstract: BACKGROUND AND AIMS: Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer and is associated with an increased lifetime risk of gastric and duodenal cancers of 8–16% and 7% respectively, therefore, we aim to describe an esophagogastroduodenoscopy (EGD) surveillance program for upper gastrointestinal (GI) precursor lesions and cancer in LS patients. METHODS: Patients who either had positive genetic testing or met clinical criteria for LS who had a surveillance EGD at our institution from 1996 to 2017 were identified. Patients were included if they had at least two EGDs or an upper GI cancer detected on the first surveillance EGD. EGD and pathology reports were extracted manually. RESULTS: Our cohort included 247 patients with a mean age of 47.1 years (SD 12.6) at first EGD. Patients had a mean of 3.5 EGDs (range 1–16). Mean duration of follow-up was 5.7 years. Average interval between EGDs was 2.3 years. Surveillance EGD detected precursor lesions in 8 (3.2%) patients, two (0.8%) gastric cancers and two (0.8%) duodenal cancers. Two interval cancers were diagnosed: a duodenal adenocarcinoma was detected 2 years, 8 months after prior EGD and a jejunal adenocarcinoma was detected 1 year, 9 months after prior EGD. CONCLUSIONS: Our data suggest that surveillance EGD is a useful tool to help detect precancerous and cancerous upper GI lesions in LS patients. To our knowledge, this is the first study to examine a program of surveillance EGDs in LS patients. More data are needed to determine the appropriate surveillance interval.
Published: 2021

17. Progressive lateralization and constant hip geometry in children with DDH, NDH, and LCPD following hip reconstructive surgery: a cohort study of 73 patients with a mean follow-up of 4.9 years

Author: Tobias Gotterbarm, Christina Haas, Stella Stevoska, Manuel Gahleitner, Lorenz Pisecky, Christian Stadler, Gerhard Großbötzl, and Matthias C Klotz
Subjects: Subluxation, Reconstructive surgery, medicine.medical_specialty, business.industry, medicine.medical_treatment, Geometry, Retrospective cohort study, General Medicine, Osteotomy, medicine.disease, Femoral head, medicine.anatomical_structure, Orthopedic surgery, medicine, Orthopedics and Sports Medicine, Surgery, Femur, business, Cohort study
Abstract: Background Pelvic and femoral osteotomies have been effective methods to treat developmental dysplasia of the hip (DDH), neurogenic dislocation of the hip (NDH), and Legg–Calvé–Perthes disease (LCPD). The aim of this study was to evaluate the mid-term results after hip reconstruction in children with DDH, NDH, and LCPD. Methods In a retrospective study, X-rays of 73 children (2–19 years) with DDH, NDH, and LCPD were measured before, 3 months, and at final follow-up (FU) after hip reconstructive surgery (open reduction, and femoral and/or pelvic osteotomy ± soft-tissue procedures between 2008 and 2018). Measurement of hip geometry included acetabular index (AI), center-edge angle (CE), and Reimers migration index (RMI). Mean follow-up time at final FU was 4.9 years. P value was set P < 0.05. Results After surgery (femoral osteotomy: 84 hips, Salter innominate osteotomy: 21 hips, Pemberton osteotomy: 30 hips, open reduction: 28 hips, Chiari osteotomy: 4 hips, and soft-tissue release: 24 hips), hip geometry parameters improved significantly. Nevertheless, at final FU, there was deterioration in hip geometry with femoral head lateralization (RMI) compared to the data at 3 months after surgery (RMI: preop/3 months/final FU: 40.6 ± 16.1%/6.1 ± 9.0/15.4 ± 16.0%; CE: 11.3° ± 20.0°/30.2° ± 9.5°/27.9 ± 15.4°; AI: 28.8° ± 9.6°/19.1° ± 7.6°/18.3 ± 7.6°). Sub-group analysis did not show differences concerning the progression of RMI in DDH, NDH, and LCPD at final FU. Regardless of basic disease, the lateralization was observed in all three groups (DDH, NDH, and LCPD) and statistically significant comparing X-rays 3 months postoperatively to maximum follow-up (DDH; NDH; LCPD: 2.7 ± 6.8%/7.6 ± 10.1%; 13.7 ± 15.3%/22.8 ± 19.8%; 1.7 ± 4.1%/14.9 ± 11.3%). Additional soft-tissue release techniques in patients with DDH or NDH did not show postoperative differences with statistical significance. Concerning surgical techniques, a connection between the lower RMI and the procedure of osteotomy of the ilium was found. In 25 patients, (34%) complications were observed: superficial skin lesions in 8, deep skin lesions in 3, contraction of adductors in 3, subluxation in 2, dislocations of the cast in 2, osteonecrosis of the femoral head in 2 cases, reluxation in 1, infection of the implanted plate in 1, compliance problem in 1, delayed bone healing in 1, and contraction of knee flexors in 1 case. Discussion The basic results of this study show a significant improvement of hip geometry at a follow-up of 4.9 years and prove findings of previously published literature. Moreover, the study was able to show a progression of RMI in all patient groups, which have undergone reconstructive surgery, despite basic hip geometry data (AI, CE angle) did not change. Those findings were independent from underlying pathology. Complications were counted in 34% of the patients and involved all known adverse events after hip reconstructive surgery. This makes clear why annual follow-up checks are needed not to miss the right indication for revision surgery. Clinical relevance Evidence level: Level IV, case series. Trial registration: This manuscript is part of a prospective randomized clinical trial, registered in the German Clinical Trials Register DRKS-ID: DRKS00016861.
Published: 2021

18. Seroconversion of rheumatoid arthritis patients after yellow fever vaccination

Author: Thelma Larocca Skare, Claudia Nunes Duarte dos Santos, Bárbara Stadler Kahlow, Betina Soares Dos Reis, Felipe Cintra Staub, Camila Zanluca, and Andrea Cristine Koishi
Subjects: medicine.medical_specialty, Attenuated vaccine, Tofacitinib, business.industry, Yellow fever, General Medicine, medicine.disease, Vaccination, Rheumatology, Prednisone, Internal medicine, Rheumatoid arthritis, medicine, Rituximab, Seroconversion, business, medicine.drug
Abstract: Vaccination is a current strategy used to prevent infections in patients with immune-mediated rheumatic diseases. However, the use of live-attenuated vaccines prepared from living microorganisms in these patients should be avoided due to the risk of acquiring infections. The present study aimed to investigate the efect of the yellow fever (YF) vaccine (a live-attenuated vaccine) in 12 patients with rheumatoid arthritis (RA). The sample comprised 12 patients (9 females and 3 males; mean age 52.2±6.5 years) with RA, who inadvertently received fractionated 17D yellow fever vaccination during an outbreak of this disease. In this cohort, 10 were administered lefunomide; 7 were administered methotrexate; 6 were administered prednisone (median dose of 5.0 mg/day); 6 took biologic drugs; and 1 took tofacitinib. All but one patient (used rituximab, prednisone, and methotrexate) seroconverted. None of them developed clinical signs of infection after the procedure. The fractionated dose of the YF vaccine is efective and safe in the observed sample.
Published: 2021

19. Comparison Between 5-Azacytidine Treatment and Allogeneic Stem-Cell Transplantation in Elderly Patients With Advanced MDS According to Donor Availability (VidazaAllo Study)

Author: Uwe Platzbecker, Aristoteles Giagounidis, Richard F. Schlenk, Gesine Bug, Matthias Stelljes, Katja Sockel, Wolfgang Bethge, Gabriele Bleckert, Christine Wolschke, Guido Kobbe, Kerstin Schäfer-Eckart, Dietrich W. Beelen, Marion Heinzelmann, Detlef Haase, Florian Nolte, Michael Stadler, Nicolaus Kröger, Jan Krönke, Dominik Wolf, Hannes Buchner, Gerald Wulf, and Christof Scheid
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Myelodysplastic syndromes, Medizin, MEDLINE, medicine.disease, Transplantation, 03 medical and health sciences, 0302 clinical medicine, Curative treatment, 030220 oncology & carcinogenesis, Internal medicine, medicine, Stem cell, business, 030215 immunology
Abstract: PURPOSE In contrast to 5-azacytidine (5-aza), allogeneic stem-cell transplantation (HSCT) represents a curative treatment strategy for patients with myelodysplastic syndromes (MDS), but therapy-related mortality (TRM) limits its broader use in elderly patients with MDS. The present prospective multicenter study compared HSCT following 5-aza pretreatment with continuous 5-aza treatment in patients with higher-risk MDS age 55-70 years. METHODS One hundred ninety patients with a median age of 63 years were enrolled. Patients received 4-6 cycles of 5-aza followed by HLA-compatible HSCT after reduced-intensity conditioning or by continuous 5-aza if no donor was identified. RESULTS Twenty-eight patients did not fulfill inclusion criteria (n = 20), died (n = 2) withdrew informed consent (n = 5), or were excluded for an unknown reason (n = 1). 5-aza induction started in 162 patients, but only 108 (67%) were eligible for subsequent allocation to HSCT (n = 81) or continuation of 5-aza (n = 27) because of disease progression (n = 26), death (n = 12), or other reasons (n = 16). Seven percent died during 5-aza before treatment allocation. The cumulative incidence of TRM after HSCT at 1 year was 19%. The event-free survival and overall survival after 5-aza pretreatment and treatment allocation at 3 years were 34% (95% CI, 22 to 47) and 50% (95% CI, 39 to 61) after allograft and 0% and 32% (95% CI, 14 to 52) after continuous 5-aza treatment ( P < .0001 and P = .12), respectively. Fourteen patients progressing after continuous 5-aza received a salvage allograft from an alternative donor, and 43% were alive at last follow-up. CONCLUSION In older patients with MDS, reduced-intensity conditioning HSCT resulted in a significantly improved event-free survival in comparison with continuous 5-aza therapy. Bridging with 5-aza to HSCT before is associated with a considerable rate of dropouts because of progression, mortality, and adverse events.
Published: 2021

20. Eosinophilic renal cell carcinoma with isolated MTOR mutation metastatic to the liver: a novel case

Author: Jeremy P. Segal, Walter M. Stadler, Tatjana Antic, and Melissa Y. Tjota
Subjects: Renal cell carcinoma, business.industry, Eosinophilic, Mutation (genetic algorithm), medicine, Cancer research, medicine.disease, business, PI3K/AKT/mTOR pathway, Pathology and Forensic Medicine
Published: 2021

21. Diagnostic pathway and stage migration of sinonasal malignancies in the era of the COVID‐19 pandemic

Author: Meerwein, Christian M, Stadler, Thomas M, Balermpas, Panagiotis, Soyka, Michael B, Holzmann, David, University of Zurich, and Meerwein, Christian M
Subjects: medicine.medical_specialty, tumor, Coronavirus disease 2019 (COVID-19), RD1-811, delay, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, sinonasal, Malignancy, Interquartile range, Allergy, Rhinology, and Immunology, Internal medicine, Pandemic, medicine, Stage (cooking), COVID, Original Research, business.industry, nasopharyngeal carcinoma, pandemic, Cancer, General Medicine, medicine.disease, 10044 Clinic for Radiation Oncology, Stage migration, 2746 Surgery, 2733 Otorhinolaryngology, Nasopharyngeal carcinoma, Otorhinolaryngology, RF1-547, Surgery, business, nasal vestibule carcinoma, malignancy
Abstract: Objectives The COVID‐19 pandemic bears the risk of delayed cancer diagnoses. Methods Study on the diagnostic pathway of sinonasal malignancies during the COVID‐19 pandemic. Results Median time from first symptom to treatment initiation was not increased during the pandemic: 137 days (interquartile range [IQR] 104‐193) vs 139 days (IQR 103‐219) (P = .60). Median time from first appointment at our institution to treatment initiation was even reduced in 2020: 18 days (IQR 11‐25) vs 11 days (IQR 7‐17) (P = .02). A trend toward advanced tumor stages during the pandemic was seen: 11/30 patients (36.7%) ≥ stage 4 in 2018 to 2019 vs 12/19 patients (63.2%) ≥ stage 4 in 2020 (P = .064). Conclusion Both, time to diagnosis and time to treatment initiation were similar during the pandemic. However, a higher proportion of advanced tumors stages was observed. Despite the pandemic, we provided a swift diagnostic workflow, including a virtual tumor board decision and a prompt treatment initiation. Level of Evidence: 4., The COVID‐19 pandemic bears the risk of delayed cancer diagnoses. This is a retrospective study on the diagnostic pathway of sinunasal malignancies during the COVID‐19 pandemic. Both, time to diagnosis and time to treatment initiation were similar during the pandemic. However, a higher proportion of advanced tumors stages was observed. Despite the pandemic, we provided a swift diagnostic workflow, including a virtual tumor board decision and a prompt treatment initiation.
Published: 2021

22. The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

Author: Lakeman, Inge M. M., Van Den Broek, Alexandra J., Vos, Juliën A. M., Barnes, Daniel R., Adlard, Julian, Andrulis, Irene L., Arason, Adalgeir, Arnold, Norbert, Arun, Banu K., Balmaña, Judith, Barrowdale, Daniel, Giraud, Sophie, Golmard, Lisa, Hake, Christopher R., Houdayer, Claude, Risch, Harvey A., Lasset, Christine, Laurent, Maïté, Spurdle, Amanda B., Hooning, Maartje J., Hopper, John L., Kets, Carolien M., Leroux, Dominique, Longy, Michel, Mari, Véronique, Mazoyer, Sylvie, Mebirouk, Noura, Mortemousque, Isabelle, Blok, Marinus J., Prieur, Fabienne, Hamann, Ute, Pujol, Pascal, Konstantopoulou, Irene, Heemskerk Gerritsen, Bernadette A. M., Isaacs, Claudine, Saule, Claire, Piedmonte, Marion, Schuster, Helene, Sevenet, Nicolas, Sobol, Hagay, Sokolowska, Johanna, Gómez Garcia, Encarna B., Venat Bouvet, Laurence, Claes, Kathleen B. M., Ahmed, Munaza, Teixeira, Manuel R., Barwell, Julian, Brady, Angela, Izatt, Louise, Hogervorst, Frans B. L., Brennan, Paul, Harrington, Patricia A., Henderson, Alex, Hodgson, Shirley, Kwong, Ava, Borg, Ake, Kennedy, M. John, Porteous, Mary E., Rogers, Mark T., Side, Lucy E., Snape, Katie, Walker, Lisa, Collée, J. Margriet, Jakubowska, Anna, Couch, Fergus J., Hahnen, Eric, Daly, Mary B., Dennis, Joe, Teo, Soo Hwang, Jensen, Uffe Birk, Rantala, Johanna, Dhawan, Mallika, Benitez, Javier, Domchek, Susan M., Eeles, Ros, Engel, Christoph, Legrand, Clémentine, Evans, D. Gareth, James, Paul A., Feliubadaló i Elorza, Maria Lídia, Teulé-Vega, Àlex, Foretova, Lenka, Castera, Laurent, Friedman, Eitan, Frost, Debra, Rennert, Gad, Ganz, Patricia A., Leslie, Goska, Garber, Judy, Hulick, Peter J., Imyanitov, Evgeny N., Glendon, Gord, Thomassen, Mads, Janavicius, Ramunas, Mulligan, Anna Marie, Hollestelle, Antoinette, Jager, Agnes, Koppert, Linetta B., Cook, Jackie, Koudijs, Marco, Kriege, Mieke, Meijers Heijboer, Hanne E. J., Schmutzler, Rita K., Mensenkamp, Arjen R., Dunning, Alison M., Mooij, Thea M., Oosterwijk, Jan C., Caux Moncoutier, Virginie, Singer, Christian F., Berthet, Pascaline, Caldés, Trinidad, Van den Ouweland, Ans M. W., Van der Baan, Frederieke H., Van der Hout, Annemieke H., Van der Kolk, Lizet E., Van der Luijt, Rob B., Thull, Darcy L., Van Deurzen, Carolien H. M., Sharma, Priyanka, Van Doorn, Helena C., Bignon, Yves Jean, Colas, Chrystelle, Van Engelen, Klaartje, Brewer, Carole, Van Hest, Liselotte P., Van Os, Theo A. M., Caligo, Maria A., Verhoef, Senno, Tischkowitz, Marc, Vogel, Maartje J., Wijnen, Juul T., Lalloo, Fiona, Beesley, Jonathan, Fox, Stephen, Collonge Rame, Marie Agnès, Simard, Jacques, Holland, Helene, Jiao, Yue, John, Esther M., Joseph, Vijai, Gerdes, Anne Marie, Karlan, Beth Y., Lesueur, Fabienne, Loud, Jennifer T., Lubiński, Jan, Manoukian, Siranoush, Mcguffog, Lesley, Miller, Austin, Coupier, Isabelle, Gomes, Denise Molina, Barouk Simonet, Emmanuelle, Montagna, Marco, Miller, Clare, Elan, Camille, Davidson, Rosemarie, Mouret Fourme, Emmanuelle, Gayther, Simon A., Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Pauw, Antoine de, Olah, Edith, Morrison, Patrick J., Olopade, Olufunmilayo I., Van Asperen, Christi J., Park, Sue K., Parsons, Michael T., Donaldson, Alan, Belotti, Muriel, Peterlongo, Paolo, Stadler, Zsofia, Stoppa Lyonnet, Dominique, Sutter, Christian, Ong, Kai Ren, Delnatte, Capucine, Tan, Yen Yen, Toland, Amanda E., Tung, Nadine, Van Rensburg, Elizabeth J., Vega, Ana, Wappenschmidt, Barbara, Devilee, Peter, Eason, Jacqueline, Chung, Wendy K., Bernstein, Jonine L., Offit, Kenneth, Aalfs, Cora M., Hanson, Helen, Godwin, Andrew K., Easton, Douglas F., Bonadona, Valérie, Rookus, Matti A., Chenevix-Trench, Georgia, Antoniou, Antonis C., O’shaughnessy Kirwan, Aoife, Robson, Mark, Eccles, Diana M., Schmidt, Marjanka K., Adank, Muriel A., Gemo Study Collaborators, Phillips, Kelly Anne, Embrace Collaborators, Ocgn Investigators, Goldgar, David E., Hebon Investigators, Perkins, Jo, Kconfab Investigators, Bressac de Paillerets, Brigitte, Buecher, Bruno, Caputo, Sandrine, Ausems, Margreet G. E. M., Gregory, Helen, Caron, Olivier, Faivre, Laurence, Fert Ferrer, Sandra, Gauthier Villars, Marion, Radice, Paolo, Gesta, Paul, Clinical Genetics, Medical Oncology, Surgery, Pathology, Gynecological Oncology, Schmidt, Marjanka K. [0000-0002-2228-429X], Apollo - University of Cambridge Repository, Targeted Gynaecologic Oncology (TARGON), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Schmidt, Marjanka K [0000-0002-2228-429X], HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Institut Català de la Salut, [Lakeman IMM] Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. [van den Broek AJ, Vos JAM] Division of Molecular Pathology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. [Barnes DR] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [Adlard J] Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. [Andrulis IL] Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. [Balmaña J] Hereditary cancer Genetics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Pediatric surgery, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, CCA - Cancer biology and immunology, Epidemiology and Data Science, Human Genetics, ARD - Amsterdam Reproduction and Development, APH - Personalized Medicine, APH - Quality of Care, Chapel Allerton Hospital, University of Leeds, Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto-Cancer Care Ontario, Reykjavík University, Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig–Holstein, The University of Texas M.D. Anderson Cancer Center [Houston], Unitat d'Alt Risc i Prevenció del Càncer, Vall d'Hebron University Hospital [Barcelona], University of Cambridge [UK] (CAM), Group of Human Genetics, Human Cancer Genetics Programme, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Department of Oncology, Clinical Sciences, Lund University [Lund]-Skåne University Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Section of Genetic Oncology, University of Pisa - Università di Pisa, Columbia University [New York], Ghent University Hospital, Department of Clinical Genetics, Erasmus University Medical Center [Rotterdam] (Erasmus MC)-Family Cancer Clinic, Department of Laboratory Medicine and Pathology, Mayo Clinic, Division of Population Science, Fox Chase Cancer Center, Institut Curie [Paris], Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL), CHU Grenoble, CHI Poissy-Saint-Germain, Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Lab Centraal Lab (9), MUMC+: DA KG Polikliniek (9), and Klinische Genetica
Subjects: 0301 basic medicine, Percentile, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [DISEASES], Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], SUSCEPTIBILITY ALLELES, Diàtesi, FAMILIES, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], MESH: BRCA2 Protein, Breast cancer, 0302 clinical medicine, MESH: Risk Factors, Risk Factors, Other subheadings::/diagnosis [Other subheadings], Medicine and Health Sciences, Medicine, Mama - Càncer - Diagnòstic, Family history, skin and connective tissue diseases, Genetics (clinical), MESH: Heterozygote, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], Factors de risc en les malalties, BRCA1 Protein, Hazard ratio, MESH: Genetic Predisposition to Disease, 1184 Genetics, developmental biology, physiology, article, OVARIAN, BRCA2 Protein/genetics, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], 3. Good health, 030220 oncology & carcinogenesis, Female, Malalties congènites, Adult, Heterozygote, medicine.medical_specialty, MESH: Mutation, Risk factors in diseases, Otros calificadores::/diagnóstico [Otros calificadores], Breast Neoplasms, Context (language use), MUTATION CARRIERS, Càncer de mama, afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::susceptibilidad a enfermedades::predisposición genética a la enfermedad [ENFERMEDADES], 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, Humans, Genetic Predisposition to Disease, MESH: BRCA1 Protein, Retrospective Studies, BRCA2 Protein, MESH: Humans, business.industry, Proportional hazards model, CONSORTIUM, Breast Neoplasms/diagnosis, MESH: Adult, MESH: Retrospective Studies, Retrospective cohort study, medicine.disease, Confidence interval, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, BRCA1 Protein/genetics, 3111 Biomedicine, business, MESH: Female, MESH: Breast Neoplasms
Abstract: Predicció de risc de càncer de mama; Dones europees; Variant patògena heterozigota Predicción del riesgo de cáncer de mama; Mujeres europeas; Variante patógena heterocigota Breast cancer risk prediction; European women; Heterozygous pathogenic variant Purpose To evaluate the association between a previously published 313 variant–based breast cancer (BC) polygenic risk score (PRS313) and contralateral breast cancer (CBC) risk, in BRCA1 and BRCA2 pathogenic variant heterozygotes. Methods We included women of European ancestry with a prevalent first primary invasive BC (BRCA1 = 6,591 with 1,402 prevalent CBC cases; BRCA2 = 4,208 with 647 prevalent CBC cases) from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), a large international retrospective series. Cox regression analysis was performed to assess the association between overall and ER-specific PRS313 and CBC risk. Results For BRCA1 heterozygotes the estrogen receptor (ER)-negative PRS313 showed the largest association with CBC risk, hazard ratio (HR) per SD = 1.12, 95% confidence interval (CI) (1.06–1.18), C-index = 0.53; for BRCA2 heterozygotes, this was the ER-positive PRS313, HR = 1.15, 95% CI (1.07–1.25), C-index = 0.57. Adjusting for family history, age at diagnosis, treatment, or pathological characteristics for the first BC did not change association effect sizes. For women developing first BC
Published: 2021

23. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Author: Nepogodiev, Dmitri, Simoes, Joana FF, Elizabeth, Li, Picciochi, Maria, Glasbey, James C, Baiocchi, Glauco, Blanco‐colino, Ruth, Chaudhry, Daoud, Alameer, Ehab, El‐boghdadly, Kariem, Wuraola, Funmilola, Ghosh, Dhruva, Gujjuri, Rohan R, Harrison, Ewen M, Lule, Herman, Kaafarani, Haytham, Khosravi, Mohammad, Kronberger, Irmgard, Leventoğlu, Sezai, Mann, Harvinder, Mclean, Kenneth A, Mengesha, Mengistu Gebreyohanes, Modolo, Maria Marta, Ntirenganya, Faustin, Norman, Lisa, Outani, Oumaima, Pius, Riinu, Pockney, Peter, Qureshi, Ahmad Uzair, Roslani, April Camilla, Satoi, Sohei, Shaw, Catherine, Bhangu, Aneel, Omar, Omar M, Ahmed, Waheed‐ul‐rahman, Argus, Leah, Ball, Alasdair, Bywater, Edward P, Brar, Amanpreet, Dawson, Brett E, Duran, Irani, Elhadi, Muhammed, Jones, Conor S, Kamarajah, Sivesh K, Keatley, James M, Lawday, Samuel, Marson, Ella J, Ots, Riinu, Santos, Irène, Taylor, Elliott H, Trout, Isobel M, Varghese, Chris, Venn, Mary L, William, Xu, Dajti, Irida, Gjata, Arben, Kacimi, Salah Eddine Oussama, Boccalatte, Luis, Cox, Daniel, Townend, Philip, Aigner, Felix, Kronberger, Irmgard Elisabeth, Samadov, Elgun, Alderazi, Amer, Hossain, Kamral, Padmore, Greg, Ramshorst, Gabrielle, Lawani, Ismaïl, Cerovac, Anis, Delibegovic, Samir, Gomes, Gustavo Mendonça Ataíde, Buarque, Igor Lima, Gohar, Muhammad, Slavchev, Mihail, Nwegbu, Chukwuemeka, Agarwal, Arnav, Martin, Janet, Ng‐kamstra, Joshua, Olivos, Maricarmen, Lou, Wenhui, Ren, Dong‐lin, Calvache, Jose Andres, Perez Rivera, Carlos J, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Jiménez, Pablo Mijahil Avilés, Gouvas, Nikolaos, Klat, Jaroslav, Novysedlák, René, Amisi, Nicolas, Christensen, Peter, El‐hussuna, Alaa, Batista, Sylvia, Lincango‐naranjo, Eddy, Emile, Sameh, Sandoval, Danilo Alfonso Arévalo, Dhufera, Hailu, Hailu, Samuel, Mengesha, Mengistu G, Kauppila, Joonas H, Arnaud, Alexis P, Demetrashvili, Zaza, Albertsmeier, Markus, Lederhuber, Hans, Löffler, Markus W., Acquah, Daniel Kwesi, Ofori, Bernard, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Aguilera‐arevalo, Maria‐lorena, Recinos, Gustavo, Mersich, Tamás, Wettstein, Dániel, Kembuan, Gabriele, Milan, Peiman Brouki, Khosravi, Mohammad Hossein, Mozafari, Masoud, Hilmi, Ahmed, Mohan, Helen, Zmora, Oded, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Fujimoto, Yuki, Kuroda, Naoto, Abou Chaar, Mohamad K., Ayasra, Faris, Fakhradiyev, Ildar, Hamdun, Intisar Hisham Said, Jin‐young, Jang, Jamal, Mohammad, Karout, Lina, Gulla, Aiste, Rasoaherinomenjanahary, Fanjandrainy, Samison, Luc Hervé, Sánchez, Iran Irani Durán, Gonzalez, Diana Samantha, Martinez, Laura, Martínez, María José, Nayen, Alejandra, Medina, Antonio Ramos‐De, Nunez, Jade, Nashidengo, Pueya Rashid, Shah, Rakesh, Shrestha, Ashish Lal, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, Wright, Deborah, Abdur‐rahman, Lukman, Ademuyiwa, Adesoji, Adisa, Adewale, Osinaike, Babatunde, Seyi‐olajide, Justina, Williams, Omolara, Williams, Emmanuel, Pejkova, Sofija, Al Balushi, Zainab, Sayyed, Raza, Mohsen, Mustafa Abo, Abukhalaf, Sadi A., Cukier, Moises, Gomez‐fernandez, Hugo, Yip, Sebastian Shu, Ojeda, Ximena Paola Vasquez, Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel F., Zarour, Ahmad, Bonci, Eduard‐alexandru, Negoi, Ionut, Efetov, Sergey, Kochetkov, Viktor, Litvin, Andrey, Ingabire, Jc Allen, Bucyibaruta, Georges, Faustin, Ntirenganya, Habumuremyi, Sosthene, Imanishimwe, Alphonsine, Dieu, Haragirimana Jean, Munyaneza, Emmanuel, Ncogoza, Isaie, Ndong, Abdourahmane, Radenkovic, Dejan, Chew, Min Hoe, Koh, Frederick, Ngu, James, Panyko, Arpád, Bele, Uros, Košir, Jurij Aleš, Daoud, Hassan, Bravo, Ana Maria Minaya, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Adam, Mohammed Elmujtba Adam Essa, Rutegård, Martin, Sund, Malin, Adamina, Michel, Gialamas, Eleftherios, Horisberger, Karoline, Alshaar, Muhammad, Huang, Abel, Lohsiriwat, Varut, Charles, Shane, Jlassi, Haithem, Isik, Arda, Lekuya, Hervé Monka, Kopetskyi, Slava, Alsaadi, Hayder, Alshryda, Sattar, Alser, Osaid, Bankhead‐kendall, Brittany, Breen, Kerry, Mashbari, Hassan, Cal, Fernando Bonilla, Al‐naggar, Hamza, Maimbo, Mayaba, Mazingi, Dennis, Abbott, Tom, Akhbari, Melika, Benson, Ruth, Bhanderi, Shivam, Biccard, Bruce, Caruana, Edward, Chakrabortee, Sohini, Chapatwala, Reema, Costas‐chavarri, Ainhoa, Demetriades, Andreas K, Desai, Anant, Di Saverio, Salomone, Drake, Thomas, Edwards, John, Evans, Jonathan, Fiore, Marco, Ford, Samuel, Fotopoulou, Christina, Fowler, Alexander, Futaba, Kaori, Ganly, Ian, James, Harelimana Grace, Griffiths, Ewen, Gronchi, Alessandro, Hutchinson, Peter, Hyman, Gabriella Yael, Incorvia, Joseph, Jain, Ritu, Jenkinson, Michael, Khan, Tabassum, Knight, Stephen Richard, Kolias, Angelos, Kudsk‐iversen, Søren, Kwan, Tsun Yu, Leung, Elaine, Mayol, Julio, Mckay, Siobhan, Meara, John G., Mills, Emily, Moug, Susan, Patel, Akshay, Perinotti, Roberto, Rice, Henry E., Roberts, Keith, Schache, Andrew, Shaw, Richard, Smart, Neil, Stephens, Matthew, Stewart, Grant D., Teasdale, Ella, Vaughan‐shaw, Peter, Vidya, Raghavan, Wright, Naomi, Zimmelman, Natalie, Agastra, Ervis, Thereska, Dariel, Lucchini, Sergio Martin, Laudani, Veronica, Chwat, Carina, Salazar, Ivana Ines Pedraza, Pantoja Pachajoa, Diana Alejandra, Duro, Agustin, Arancibia, José Alfredo Calderón, D’Aulerio, Giuliana, Dudi‐venkata, Nagendra, Egoroff, Natasha, Farik, Shebani, Lott, Natalie, Moss, Jana‐lee, Rennie, Sarah, Tan, Lorwai, Uyen Giao, Vo, Watson, David, Watters, David, Bright, Tim, Hollington, Paul, Zhou, Xuanyu, Kroon, Hidde M, Farfus, Anthony, Barker, John, Watson, Eleanor, Stevens, Sean, Latif, Haider, Dawson, Amanda Caroline, Chuan, Alwin, Muralidharan, Vijayaragavan, Wong, Enoch, Ackermann, Travis, Pacilli, Maurizio, Hodgson, Russell, Heriot, Alexander, Choong, Peter, Brown, Wendy, Lidder, Surjit, Yeung, Justin, Traeger, Luke, Regalo, Guillermo, Gourlay, Ralph, Badiani, Sarit, Koh, Cherry, Putnis, Soni, Haider, Fayza, Mitul, Ashrarur Rahman, Komen, Niels, Dhondt, Bert, Cappeliez, Serge, Pigeolet, Manon, Schoneveld, Martijn, Stijns, Jasper, Oosterlinck, Wouter, Flamey, Nicolas, Kpangon, Cyrille, Agbadebo, Mouhamed, Tobome, Smèvo Romaric, Barros, Aldo Vieira, Júnior, Samuel Aguiar, Amaral Campos, Heloisa Galvão, Gross, Jefferson, Coimbra, Felipe José Fernandez, Kowalski, Luiz Paulo, Makdissi, Fabiana, Nakagawa, Suely, Neto, Joao Pedreira Duprat, Vartanian, Jose Guilherme, Yazbek, Guilherme, Zequi, Stenio C, Flumignan, Ronald, Jaworska, Natalia, Dell, Angela, Shanthanna, Harsha, Behzadi, Abdollah, Nessim, Carolyn, Mozel, Michelle, St‐germain, Pascal, Russell, Crispin, Groot, Gary, Safieddine, Najib, Wijeysundera, Duminda, Eskander, Antoine, Chadi, Sami, Mackenzie, Shawn, Flexman, Alana, Heredia, Fernando, Villanueva, Julio, Waissbluth, Sofia, Macchiavello, Roberto, Escudero, Mario I, Fuentes, Tyare, Mimica, Ximena, Saenz, Dinimo Bolivar, Caicedo, Lina, Alzate, Juan Pablo, Luna, Joaquin, Alonso, Nestor Fabian Pedraza, Silva, Camilo Ortiz, Rodriguez, Juliana, Silva‐igua, Liliana, Torres, Martha Luz, Trujillo, Lina María, Calvache, Albaro José Nieto, Balanta‐melo, Julián, Figueroa‐casanova, Rafael, García‐montoya, Oscar‐julián, Toro, Carlos Andres Marulanda, Botero, Marcela Velez, Arango, Maria Clara Mendoza, Martinez, Eneida Diaz, Perdomo, Valentina Gutiérrez, Montenegro, Emileth, Rodriguez‐abreu, Julia, Mejía, Dolores, Abouelnagah, Galal, Shehata, Sameh, Rida, Ahmed Hossam Eldin Fouad, Hassan, Ramy A., Saad, Mahmoud M., Loaloa, Mohamed Reda, Mostafa, Badr, Qassem, Mohamed, Fahmy, Mohamed, Abozied, Hesham, Azzam, Ahmed Y, Ghozy, Sherief, Sallam, Asser, Shehta, Ahmed, Abdelkhalek, Mohamed, Samaka, Rehab, Morsy, Amr, Sherif, Ahmed Elshawadfy, Negussie, Abraham, Fisseha, Tigist, Shumbash, Kibruyisfaw, Abebe, Metasebia, Yasin, Seid Mohammed, Akililu, Yemisirach Bizuneh, Megersa, Abebe, Tefera, Teshome, Assefa, Melatework, Atnafu, Bahru, Tsegaye, Bereket, Bezabih, Yoseph Solomon, Sisay, Silamlak, Bekele, Kebebe, Jira, Moa, Derilo, Habtamu, Degefa, Eyueal, Tadesse, Anteneh, Nidaw, Melkamu, Sarjanoja, Elise, Testelin, Sylvie, Boucher, Sophie, Jouffret, Lionel, Lakkis, Zaher, Le Bian, Alban Zarzavadjian, Harper, Luke, Déserts, Marc Danguy, André, Benoît, Slim, Karem, Verhaeghe, Romain, Police, Andrea, Girard, Edouard, Chebaro, Alexandre, Nkembi, Armande Subayi, Arnalsteen, Laurent, Ballouhey, Quentin, Mege, Diane, Jeandel, Clement, Duchalais, Emilie, Bouche, Pierre‐alban, Manceau, Gilles, Crétolle, Célia, Hervieux, Erik, Girard, Noémie, Seguin‐givelet, Agathe, Gaujoux, Sebastien, De Simone, Belinda, Boisson, Matthieu, Bergeat, Damien, Fredon, Fabien, Nappi, Francesco, Kassir, Radwan, Scalabre, Aurélien, Migliorelli, Federico, Ezanno, Anne‐cecile, Seeliger, Barbara, Vaysse, Charlotte, Charbonneau, Helene, Misrai, Vincent, Abbo, Olivier, Angeles, Martina Aida, Brunaud, Laurent, Modabber, Ali, Wolf, Sebastian, Kamphues, Carsten, Höhn, Philipp, Glowka, Tim R., Rokohl, Alexander Christopher, Bork, Ulrich, Fluegen, Georg, Horch, Raymund E., Schmedding, Andrea, Schnitzbauer, Andreas, Eberbach, Helge, Schlager, Daniel, Spelsberg, Fritz, Keppler, Lena, Hecker, Andreas, Wolfer, Susanne, Ronellenfitsch, Ulrich, Nitschke, Christine, Peiper, Christian, Hakami, Ibrahim, Welter, Stefan, Nikolaieva, Karine, Roth, Andreas, Lindert, Judith, Gousias, Konstantinos, Rissmann, Anke, Linz, Valerie Catherine, Rahbari, Nuh, Rassweiler‐seyfried, Marie‐claire, Gut, Anna Eleonora, Gempt, Jens, Reim, Daniel, Wagner, Arthur, Keppler, Alexander M., Stoleriu, Mircea Gabriel, Saier, Tim, Stadler, Josef, Kaiser, Julia Christina, Brunner, Stefan M., Pfister, Karin, Herzberg, Jonas, Nowak, Kai, Reinhard, Tobias, Stavrou, Gregor A., Königsrainer, Alfred, Konrads, Christian, Quante, Markus, Laban, Simon, Pusch, Silke, Hirschburger, Markus, Doerner, Johannes, Wiegering, Armin, Tampaki, Ekaterini Christina, Ruiz, Alitza Gutiérrez, Rodas, Alejandra, Portilla, Ana Lucía, Carrera, Jacqueline, Duarte, Amalia Barrios, Lowey, Megan, Barillas, Sabrina, Suroy, Atul, Vaishnav, Dhaivat, Chowdappa, Raghunandan Gorantlu, Madabhavi, Irappa, Bhat, Dhananjaya, Venkatappa, Sunil Kumar, Thakar, Sumit, Jain, Kavitha, Kumar, Aruna, Nagar, Manoj, Mishra, Tushar, Sekar, Arunkumar, Gupta, Anand, Kaman, Lileswar, Karthigeyan, Madhivanan, Tripathi, Manjul, Rammohan, Ashwin, Vayoth, Sudheer Othiyil, Rajanbabu, Anupama, Subbian, Anbukkani, Gupta, Rahul, Raut, Monish, Evelyn, Nissi, Kannaiyan, R Lavanya, Matai, Anil, Misra, Sanjeev, Bhende, Vishal, Muthu, Sathish, Ghosh, Indranil, Sharma, Abhishek, Bajaj, Ankur, Rajan, Shiv, Agarwal, Gaurav, Pawar, Pranay, Alexander, Philip, Vijayakumar, M Vijayakumar, Hameed, Zeeshan, Badareesh, L, Chaudhry, Navneet Kumar, Baliarsing, Lipika, Dharap, Satish, Kulkarni, Amruta, Thyavihally, Yuvaraja, Sharma, Rahul Deo, Pramesh, C S, Soni, Rajesh, Dube, Surya Kumar, Sharma, Shilpa, Singh, Harvinder, Bains, Lovenish, Ghodke, Rahul, Kumar, Ashwani, Sodhai, Vivek, Maji, Suvendu, Basu, Somprakas, Mahakalkar, Chandrashekhar, Kannan, Ravi, Mehraj, Asif, Ranganath, N, Phadnis, Ashish, Yadev, I, Kavalakat, Alfie, Mittal, Rohin, Vallam, Karthik Chandra, Akhavizadegan, Hamed, Maleki, Esmaeil Rezghi, Kandevani, Naser Yousefzadeh, Ikele, Hilary, Mcnestry, Catherine, Fleming, Christina, O’Brien, Stephen, Elwahab, Sami Abd, Davis, Niall, Javadpour, Mohsen, Mcdonnell, Brendan, Connor, Clare O, Bolger, Jarlath, Clancy, Cillian, Croghan, Stefanie M, Donlon, Noel, Cullinane, Carolyn, Creavin, Ben, Muheilan, Muheilan, Earley, Helen, Kabir, Syed Mohammad Umar, Fahadullah, Muhammad, Ryan, Éanna, Connelly, Tara, Hashimoto, Daisuke, Alqudah, Majdi Ali, Alajalen, Amer, Omari, Rand Y., Qasem, Abdulrahman, Alawneh, Yazan, Ahmad, Amer, Aladawi, Omar, Alrayes, Bourhan, Haidar, Hanan, Husain, Shatha, Qassem, Faisal, Sumadi, Adnan, Salhiyeh, Ala’a Abu, Al‐manaseer, Balqees Mahmoud, Alsunna, Zaid, Ra’Ed, Hazim, Hamad, Faten Reyad Bani, Abuleil, Amro, Jimaale, Elmi Ahmed Mohamed, Abu‐mehsen, Marah, Olaywah, Noor, Wafi, Omar, Ababneh, Hazim, Abu‐ismail, Luai, Khamees, Almu’Atasim, Alkhatib, Ahmad, Bolatbekova, Raikhan, Kulimbet, Mukhtar, Nurgozhin, Talgat, Saliev, Timur, Zhussupov, Baurzhan, Almabayev, Ydyrys, Kaidarova, Dilyara, Tamoos, Khalil, Aqeelah, Ahmed, Mohammed, Alsnosy Abdullah Khalefa, Al Maadany, Faraj, Alkadeeki, Ghadah, Gahwagi, Milad, Aldressi, Wafa, Amnaina, Mohamed, Alansari, Arowa Hassan Abdulrahman, Alkaseek, Akram, Yagoub, Ghozlan, Amer, Anass Ben, Salem, Marwa, Almugaddami, Ayman, Burgan, Dania, Abdelkabir, Mohammed, Alshareef, Khayriyah, Islam Ben Jouira, Rayet, Meelad, Ayman, Bouhuwaish, Ahmad, Dwaga, Sumayya Essayah, Khalifa, Houda, Almiqlash, Bushray, Suliaman, Taha, Alawami, Mohammed, Elhajdawe, Fras, Aboazamazem, Hajir, Ellojli, Ibrahim, Msherghi, Ahmed, Saleh, Ismail Ali, Alayan, Mohammed, Ndayishyigikiye, Marcel Didier, Munyika, Akutu, Plarre, Philipp, Borowski, David W, Wells, Cameron, Teague, Rebecca, Elliott, Brodie, Kieser, David, Mohyieldin, Omar, Mcintosh, Nick, Haran, Cheyaanthan, King, Jasmin, Jeong, Ha, Mcguinness, Matthew James, Adesanya, Opeoluwa, Olaogun, Julius, Akinmade, Akinola, Bwala, Kefas, Agbonrofo, Peter, Afolabi, Akinwale, Usang, Usang, Ekenze, Sebastian, Olori, Samson, Lawal, Taiwo Akeem, Okunlola, Abiodun, Kache, Stephen, Sale, Danjuma, Anyanwu, Lofty‐john, Okereke, Chukwuma, Tolani, Musliu Adetola, Filipce, Venko, Todorovic, Lazar, Stavridis, Sotir, Massoud, John George, Alsibai, Sareyah, Sultan, Rizwan, Altaf, Humera Naz, Bhatti, Abu Bakar Hafeez, Waqar, Shahzad Hussain, Aziz, Aliya, Kerawala, Asad Ali, Rai, Lajpat, Anwer, Mariyah, Tariq, Aiman, Ayub, Bushra, Niazi, Sami Ullah, Naseem, Muhammad Yasir, Sarwar, Muhammad Zeeshan, Khokhar, Muhammad Imran, Zahid, Imdad Ahmad, Majid, Haroon Javaid, Talat, Nabila, Asif, Muhammad, Chaudhary, Muhammad Hamid, Farooq, Umer, Ahmad, Siddique, Mabood, Waleed, Bukhari, Syed Imran, Tariq, Muhammad, Yaqoob, Eesha, Javed, Saad, Malik, Muhammad Usman, Yaqoob, Hassan Nawaz, Pacheco, Glenda Marina Falcon, Melendez, Robinson Mas, Urbina, Arazzelly Del Pilar Paucar, Chiuyari, Jose Rios, Alvarado, Carlos Eduardo Otiniano, Lau, Lorena Fuentes Rivera, Borda‐luque, Giuliano, Niquen‐jimenez, Milagros, Arias, Claudia, Zegarra, Sergio, Pallardel, Jenner Betalleluz, Oscco, Regina Amparo Ugarte, Mendiola, Gian, Colmenares, Yahaira Tatiana Carpio, Zapata, Carlos Shiraishi, Ortiz, Maria Rosa, Borges, Filipe Castro, Viveiros, Octavio, Serralheiro, Pedro, Santos‐costa, Paulo, Mendes, Filipa, Melo, Miguel Rocha, Cardoso, Paulo, Soares, Ana, Pereira, Rita Gonçalves, Silva, Nelson, Caiado, André, Sacras, Maria Luís, Azevedo, Pedro, Almeida‐reis, Rui, Oliveira, João, Nogueiro, Jorge, Sampaio‐alves, Mafalda, Costa, Luciana Cidade, Baía, Catarina, Deus, Ana Cláudia, Branquinho, Rita, Marçal, André, Tojal, André, Makkai‐popa, Silviu Tiberiu, Mironescu, Aurel, Grama, Florin, Toma, Elena Adelina, Filipescu, Daniela, Bacalbasa, Nicolae, Motas, Natalia, Ionescu, Sebastian, Ginghina, Octav, Costea, Radu, Zarnescu, Narcis Octavian, Drasovean, Radu, Dimofte, Mihail‐gabriel, Porumb, Vlad, Kirov, Mikhail, Molitvin, Yegor, Pykhteev, Vadim, Raevskaya, Marianna, Butyrskii, Aleksandr, Alshahrani, Mushabab, Althumairi, Azah, Alzerwi, Nasser, Al Ameer, Ahmed, Madkhali, Tariq, Almulhim, Abddulrahman Saleh, Ghazwani, Salman, Ayoub, Abdu, Iskander, Othman, Ghunaim, Mohammed, Alharthi, Mohammed, Alzaidi, Turki M, Alyami, Mohammad, Al Amri, Abdulrahman, Alfakhri, Abdullah, Alhefdhi, Amal, Chowdhury, Sharfuddin, Nouh, Thamer, Alshehri, Ameen, Alzahrani, Abdulrahman, Alalawi, Yousef, Awad, Selmy, Konate, Ibrahima, Tendeng, Jacques, Teo, Nan Zun, Aqil, Sabra, López, Cristina Barrena, Mozo, Ana Sánchez, Infante, Antonio Rodriguez, Vivancos, Patricia Caja, Prieto, Mikel, Roman, Igor Alberdi San, Fernandez, Laura Gomez, Vives, Josep Maria Muñoz, Carreras‐castañer, Anna, Díaz‐feijoo, Berta, Sieira‐gil, Ramon, Turrado‐rodriguez, Victor, López, Anna Sánchez, Sánchez‐cabús, Santiago, Toscano, Marta Jimenez, Sin, MªPilar Canals, Laura, Saura García, Sole, Oriol Martin, Bellver, Pedro Palazon, Pérez‐bertólez, Sonia, Prat‐ortells, Jordi, Martínez, Mireia Riba, Rubio‐palau, Josep, Tarrado, Xavier, Nuñez, Jorge, Mendoza, Veronica Alonso, Bescós, Coro, Espin‐basany, Eloy, Espinosa‐bravo, Martin, Gil‐sala, Daniel, González‐suárez, Susana, Estruch, Nuria Montferrer, Mariño, Lucia Porteiro, Rodríguez‐tesouro, Ana, Portilla, Fabian Rojas, Pérez, M Pilar Tormos, Vives, Inmaculada, De Cortazar, Unai Garcia, Tudela, Kiara, Landaluce‐olavarria, Aitor, Gómez, Mercedes Estaire, Almoguera, Jorge, Ugarte‐sierra, Bakarne, Jimenez, Virginia, Bertrand, Marta, Puiggrós, Laura Cárdenas, Delisau‐puig, Olga, Garcia‐adamez, Jorge, Bergkvist, David Julià, Maldonado‐marcos, Eloy, García, Lucia Diego, Golet, Marta Roldón, Soto‐darias, Iván, Rahy‐martín, Aida Cristina, Enjuto, Diego, Ramos‐luengo, Adolfo, Fernandez, Juan Delgado, Duarte, Carolina Lugo, Thies, Cristina Ojeda, Marquez, Lucila, Vita, Diana Crego, Dziakova, Jana, Velasco, Jorge Caño, Mateo‐sierra, Olga, Quintana‐villamandos, Begoña, Valcarcel, Cristina Rey, Rio, Javier, León, Laura Román García, Di Martino, Marcello, Prada, Jorge, González, Javier Serrano, Losada, Manuel, Gomez, Jose Tomas Castell, Corripio‐sanchez, Ramon, Forero‐torres, Alexander, Morales‐puebla, José Manuel, Perez‐chrzanowska, Hanna, Gonzalez, Santiago Valderrabano, Yebes, Alvaro, Zapardiel, Ignacio, Alonso, Manuel Diez, Palacios, Nelson Morales, Sánchez, Alberto Cabañero, Fernández, Fátima Sánchez, Gurumeta, Alfredo Abad, Abad‐motos, Ane, Corella, Fernando, Ripollés‐melchor, Javier, Sanz‐gonzalez, Rosa, Fuentes, Marta Alcaraz, Martín, Maria Teresa Fernández, Espino, Pablo Calvo, Prats, Milagros Carrasco, Fernández‐lópez, Antonio‐josé, Escudero, Damián García, Soria, Vanesa Garcia, Alonso, Jesús Aarón Martínez, Ruiz‐marín, Miguel, Pérez, Beatriz Gómez, Moya‐angeler, Joaquin, Martínez, Daniel Fernández, Bayo, 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Teresa Gavaldà, Solé, Misericòrdia Jordà, Velasquez, Enrique Jose Ruiz, Núñez, Bernardo, Jimenez, Raul, Zabaleta, Jon, González‐gimeno, Maria Jose, Vázquez, Irene Ortega, Ferrer, Antonio Perez, Martín‐láez, Rubén, Suarez, Marcelo Moreno, Eiras, Miguel Angel Freiria, Ramallo‐solís, Irene, Gomez‐rosado, Juan‐carlos, Guillen, Jose Ramon Oliver, Boira, Mar Achalandabaso, Bauset, Juan Carlos Catalá, Domenech, Julio, Badenes, Rafael, Bernal‐sprekelsen, Juan Carlos, Sancho‐muriel, Jorge, De Andrés‐Asenjo, Beatriz, Tejero‐pintor, Francisco J, Vallve‐bernal, Marc, Melero, Alba Vazquez, Blasco, Laura Sánchez, Escartin, Jorge, Mallén, Victoria Duque, Srishankar, Selvaratnam, Sooriyabandara, Charitha, Basnayake, Oshan, Gunawansa, Nalaka, Weeraddana, Prabuth Dulanjan, Vimalakanthan, Thanusan, Gishanthan, Shanthamoorthy, Chandrasinghe, Pramodh, Sauvain, Marc‐olivier, Ghazal, Ahmad, Al‐sabbagh, Yusra, Alhassoun, Turki, Albared, Sara Maa, Naem, Antoine, Alnahr, Hareth, Jisry, Ghassan, Hammed, Ali, Xaviour, Okedi Francis, Turinawe, Gaston, Mubezi, Isaac, Sikakulya, Franck K., Kakeeto, Andrew, Kabweru, Wilberforce M., Kiweewa, Ronald, Matovu, Paul, Isaac, Otolia, Mashhour, Mohamed, El Helw, Amin, Kherani, Safeena, Mohamed, Awadelkarim, Abbas, Ferial Mohamed Ali, Mohammed, Diary, Aldlyami, Ehab, Kundra, Rakesh, Michael, Antony Louis Rex, Khalil, Kareem S., Dbeis, Rachel, Shaikh, Shafaque, Ferry, Jenny, Jamal, Aiman, Siddique, Haleema, Das, Rishi, Ponugoti, Nikhil, Rattanasirivilai, Pornjittra, Sultana, Asma, Mosley, Frances, Chan, Matthew, Bateman, Antony, Davies‐jones, Gareth, Georgiades, Fanourios, Ahmadi, Navid, Coonar, Aman, Baig, Mariam, Khatri, Chetan, Surendran, Arthika, Sonksen, Julian, Sinnerton, Robert, Brennan, Caitlin, Faulkner, Gemma, Greenhalgh, Michael, Emerson, Hannah, Singisetti, Kiran, Totty, Joshua, Wilson, Michael, Terence, Lo, Corbett, Harriet, Okonkwo, Ijeoma, Arbane, Gill, Kerawala, Cyrus, Parmar, Chetan, Bath, Michael, Odejinmi, Funlayo, Sagar, Jayesh, Talwar, Rishi, Newman, Samuel, Hammond, John, Moir, John, Duric, Natalie, Szakmany, Tamas, Talib, Ahmar Iftikhar, Youssef, Mina, Lewis‐lloyd, Christopher, Lami, Mariam, Ayub, Khurram, Dean, Benjamin, Balasubramanya, Supriya, Lakpriya, Sathya, Rogers, Luke, Turner, Paul, Maher, Mark, Sigamoney, Kohila, El Kafsi, Jihène, Hardie, John, Johnson, David, Henein, Christin, Hollyman, Marianne, Agarwal, Ketan, Powell, Simon, Chauhan, Govind Singh, Patel, Rakesh, Gagnier, Joel, Carmichael, Heather, Aurora, Null, Olson, Kristofor A., Etchill, Eric, Hirji, Sameer, Naunheim, Matthew, Drake, Frederick, Reinke, Caroline, Alecci, Anna, Vaysburg, Dennis, Rodriquez, Jennifer, Shih, Emily, Ban, Vin Shen, Coleman, Julia, Kaups‐fresno, Krista, Giorgakis, Emmanouil, Dinome, Maggie, Bhutiani, Neal, Alnachoukati, Omar, Aiken, Taylor, Diehl, Thomas, Gosain, Ankush, Rattan, Rishi, Ghani, Muhammad Owais Abdul, Ruzgar, Nensi Melissa, Liveris, Anna, Glass, Nina, Paranjape, Charu, Chin, Theresa, Meola, Antonio, Nicholson, Kristina, Squiers, John, Lueckel, Stephanie, Reisenauer, Janani, Callcut, Rachael, Mansour, Ahmed, Berndtson, Allison, Kornblith, Lucy, Seegert, Sara, Martins, Paulo, Al‐shehari, Mohammed, Al‐raimi, Ibrahim, Ngulube, Allan, Siamuchembu, Maphios, Mushiwokufa, Willard, Mlambo, Busisiwe, Chinyowa, Simbarashe, Bollano, Enton, Gjyli, Kostandin, Kerpaci, Jola, Vrapi, Enxhi, Zijaj, Lorena, Djahida, Bahraoui, Zohra, Belabbes Fatima, Khadidja, Kouidri, Bali, Oussama, Benallel, Nassim, Lalmi, Ismahene, Abdoun, Meriem, Aouabed, Nesrine, Bouaoud, Souad, Bouchenak, Kamel, Haif, Assia, Soualili, Zineddine, Bastet, Joaquin, Bianco, Agustín, Capitaine, Daniel, Lozada, Jorge Centeno, Esquivel, Carlos, Figueroa, Rodrigo, Garcia, Manuel, García, Pablo Martín, Gerchunoff, José Ignacio, Iascano, Fernando Martinez, Mondino, Jose, Muriel, María Emilia, Pablo, Carmignani, Passadore, Martin, Tornini, Alejandra, Traverso, Rogelio, Vargas, Lara, Zanoni, Gerardo, Berber, Norberto, Cotta, Estefanía, Di Vincenzo, Marcela, Gallino, Esteban Sebastian, Gigena, Cecilia, Grassano, Bianca, Lugones, Ignacio, Madrid, Constanza, Maricic, Maximiliano, Martinez, Antonio Alberto, Rosso, Andres, Scher, Pablo, Tachella, Sofia, Zezular, Damaris Idara Anabel, Abuawad, Carla, Forneris, Agustin Albani, Allemand, Carola, Calzaretta, Laura Gisela Alvarez, Boretto, Jorge G., Boudou, Rocio, Brandariz, Rodrigo, Buljubasich, Martin, Burchakchi, Arturo, Buttaro, Martin, Campana, Juan Pablo, Busnelli, Virginia Cano, Carminatti, Tomas, Lalín, Agustina Florencia Castro, Cereghini, Julian, Amor, María Sol Crespi, Croattini, Roberto Sebastián, Fernandez, Maria Sol, Figari, Marcelo, Fraidenraij, Uriel, Gallegos, Diego, García‐mansilla, Agustín Maria, Gonzalez, Marcos, Gonzalez, Matias Ignacio, Salazar, Esteban Gonzalez, Goransky, Jeremias, Gauna, Guillermo Hernandez, Higuera, Felipe, Holc, Fernando, Jauregui, Esteban Gabriel, Larrañaga, Juan, Liyo, Juan, Llano, Lionel, Lobos, Pablo, Luzzi, Emilia, Mastroianni, Gustavo, Mata‐suarez, Santiago Miguel, Mayer, Horacio F., Loughlin, Santiago Mc, Mendoza, Efrain, Mentz, Ricardo Esteban, Mercado, Pedro, Moyano, Pablo, Noll, Florencia, Odetto, Diego, Oliva, Agustina Rene, Vidal, Rafael Perez, Poggi, Catalina, Premoli, Eduardo Jorge, Ramos, María Lourdes, Rosas, Patricio, Rossi, Luciano, Rossi, Gustavo, Saadi, Jose, Scherñuk, Jordán, Slullitel, Pablo, Stang, María Verona, Taboada, María Victoria, Tirapegui, Sebastian, Uffelmann, Constanza, Vaccaro, Carlos, Vagni, Roberto, Valerio, Ana Clara, Zarratea, Celeste Soledad, Montal, Silvina, Morris, Brian, Valdez, Pedro, Diaz‐couselo, Fernando, Sabatini, Luciana, Alvarez, Fernando Andres, Avila, Micaela, Benitez, Nicole Benitez, Bruera, Nicolás, Doniquian, Marcelo, Gielis, Manuel, Liaño, Julian, Llahi, Florencia, Mandojana, Facundo, Páez, Walter, Parodi, Matias, Molina, Héctor Picon, Pinsak, Agustin, Viscido, German, Badra, Roberto, Belisle, Diego, Borla, Hernan, Eberle, Georgina, Esteban, Agustin, Ferrero, Carlos Ignacio, Furlan, Micaela, García, José Sebastian, Granero, Lucas, Henzenn, Mariel, Juaneda, Rodrigo, Vidal, Esteban Politi, Reyna, Guillermo Romero, Montero, José Gabriel Yaryura, Caubet, Maria Mercedes, D’Addino, José Luis, Daryanani, Deepu, Gosselink, Martijn, Ponson, Alex, Afzal, Mohamed, Amprayil, Mathew, Brooke‐smith, Mark, Chen, John, Grantham, James, Gricks, Benjamin, Hii, Amanda, Kundu, Nikhil, Liu, David, Livingston, Charles, Marshall‐webb, Matthew, Mcveay, Christina, Moore, Hamish, Nair, Gavin, Ong, Bee Shan, Parker, Dominic, Rudolph‐stringer, Victoria, Szpytma, Malgorzata, Vissapragada, Ravi, Wee, Melissa Yun, Wong, Geoffrey Yuet Mun, Barnett, Dylan Richard, Bochner, Melissa, Bolt, John, Buddingh, Karel, Coventry, Brendon, Davis, Sean, Dawson, Joseph, Denham, Stuart, Dobbins, Christopher, Fitridge, Robert, Gan, Siang Wei, Haque, Izhar‐ul, Herath, Matheesha, Jog, Shivangi, Kanhere, Harsh, Kuang, Beatrice, Lam, Yick Ho, Lambert, Virginia, Lim, Alicia, Maina, Grace, Moller, Cea‐cea, Neo, Eu Nice, Neo, Eu Ling, Nguyen, Alain, Prasad, Shalvin, Roy, Jennifer, Russell, Christine, Sammour, Tarik, Smith, Nicholas, Smith, Richard, Stranz, Conrad, Tourani, Saam, Tran, Steven, Van de Ven, Lucinda, Warren, Leigh, Whitfield, Robert, Wormald, Jamie, Yin, Yijie, Bierton, Christopher, Cribb, Benjamin, Foley, Katarina, Ong, Daniel, Watson, Matthew, Hampton, Jacob, Karam, James, Rugendyke, Anya, Zhang, Tyson, Vasey, Carolyn, Apellaniz, Eduardo, Frankel, Adam, Gahan, Lara, Guerra, Glen R, Liesegang, Amanda, Lutton, Nicholas, Maurice, Andrew, Miron, Scott, Prasad, Aveechal, Sercombe, Ashleigh, Sivapalan, Thanusan, Ahmad, Syed Danial Syed, Tee, Chin Li, Yaksich, Lachlan, Batstone, Martin, Breik, Omar, Young, Thomas, Field, Michael, Scott, Benjamin, Charlton, Gabriella, Chen, Si, Cheung, Henry Yan Chi, Gauri, Neha, Hayhurst, Ross, James, Sophie, Jang, Seyoung, Jia, Fangzhi, Zhang, Helen, Aujla, Randeep, Finsterwald, Michael, Percy, Digby, Tanaya, Alvin, Trivedi, Anand, Aylett, Andrew, Grills, Richard, Holmes, Angela, Kwok, Matthew Ming Kei, Lambers, Anton, Lambers, Leo, Lok, Evania, Nagra, Sonal, Page, Richard, Paltoglou, Nicholas, Panuganti, Vishwakar, Riddell, Sophie, Rudock, Gareth, Tan, Hannah, Underwood, Kirk, Youssef, Daniel, Amoils, Ricci, Bahtigur, Nazli, Bengeri, Savitha, Builth‐snoad, Lily, Cheah, Hock Ping, Chen, Paul, Chew, Kenneth, Chong, Alyssa, Clark, Sara, Kaul, Rhea Darbari, Devan, Eliya, Ewington, Christina, Fatima, Aleeza, Fitt, Sophia, Gaul, John, Ghosal, Paloma, Gojnich, Amy, Gunawardena, Indu, Hamer, Peter, Holmes, Samuel, Hou, Zhen, Jolly, Danielle, Kane, James Dimitri, Kaufman, Micayla, Khandelwal, Tanishq, Khanijaun, Sukhwant, Kwok, Kelvin, Latif, Edward, Laura, Sharon, Lee, Vivian, Leung, Catherine, Liang, Ina, Lin, Peter, Lun, Elizabeth Weng Yan, Luo, Haili, Victor, Ly, Jolande, Ma, Macnab, Brooke, Mcgee, Richard, Miles, Stephanie, Munro, William, Narroway, Harry, Ngan, Tin Yau, Noor, Anthony, Pahalawatta, Upuli, Park, Melissa, Parkin, Cameron, Poon, Rita, Somasundaram, Shanmugam S, Saab, Claudia, Simpson, Renwick, Steinel, Dana, Taylor, Emily, Tchen, Adrian, Thong, Shu, Tran, Kelvin, Tree, Kevin, Vance, Lucille, Wong, Ken, Victor, Yu, Zhang, Michael, Cox, Aram, Tan, David Chi Hau, Thani, Nova, Das, Shefali, Macdonald, Taigh, Salama, Paul, Sandhu, Gagandeep, Shadbolt, Rachel, Phan, Du, Townend, David, Eunmaro, Ju, Lee, Sang Mi, Barnett, Stephen, Kheslat, Hajar Hasan, Higgins, Andrew, Jamieson‐grigg, Chloe, Jenkins, Victoria, Larner, Brett, Perini, Marcos, Proud, David, Qin, Kirby, Riddiough, Georgina, Seevanayagam, Sivendran, Damien M., Wu, Zhao, Chris, Aggarwal, Sonali, Vinna, An, Battershell, Melanie, Chan, Elliot, Cheung, King Tung, Drake, Anna, Goonawardena, Janindu, Hunt, Benjamin, Christopher, Ip, Iyer, Vikram, Jain, Anshini, Kealey, Joshua, Lew, Chen, Lim, Christopher Seng Hong, Luck, Tara, Mackay, Sean, Maher, Natalie, Maroske, Georgia, Roubos, Nicholas, Sengupta, Shomik, Steen, Christopher, Tsigaras, Zac, Tuttle, Zachary, Ward, Salena, Williams, Marli, Yeap, Evie, Zhou, Jessie, Coates, Amy, Mutalima, Nora, Tran, Ton, Nataraja, Ramesh, Sharpin, Claire, Bird, David, Choy, Kay Tai, Condron, Sarah, Daruwalla, Jurstine, Anjos, Isabela, El‐khoury, Hanna, Fabian, Robert, Gillard, Andrew, Greenop, Rebecca, Issa, Michael, Lee, Sharon, Mori, Krinal, Petrakis, Nikki, Qureshi, Maryum, Sabella, Danielle, Satasivam, Prassannah, Sathianathen, Niranjan, Seow, Sean Ezekiel, Shen, Amanda, Shi, Margaret, Tabassum, Meher, Teixeira, Rodrigo, Vivian‐taylor, Josephine, Wheatley, Jennifer, Shepherd, Sally, Soucisse, Mikael, King, Sebastian, O’Connor, Brendan, Teague, Warwick, Banting, Simon, Chong, Lynn, Clatworthy, Sharnel, Cochrane, Angela, Fox, Adrian, Hii, Michael Wei, Isaacs, Anna, Johnson, Mary Ann, Knowles, Brett, Newcomb, Andrew, Price, Veronique, Raman, Jaishankar, Read, Matthew, Rowcroft, Alistair, Taylor, Lillian, Wright, Gavin, Chana, Prem, Shaw, Kalai, Bock, Jacob, Cory, Jordan, Drummond, Katharine, Lahy, Jack, Mcintire, Thomas, Price, Benjamin, Stark, Claire, Besson, Alex, Gartrell, Richard, Lauritz, Brianne, Nguyen, Ha My Ngoc, Ong, Chui Foong, Pitcher, Meron, Scullion, Lorna, Tang, Howard, Taylor, Danielle, Wolf, Brigid, Wichmann, Matthias, Davis, Amelia, Maurel, Amelie, Raubenheimer, Kyle, Campbell, Cassidy, Colaco, Ashley, Machado, Maria Julia Corbetta, Heffernan, Abbie, Karihaloo, Costa, Ludbrook, Isabella, Park, Sean SW, Peerally, Bibi Nabeeha, Singhai, Camila, Stevens, Heidi, Vavilov, Sergey, Aubin, Anne‐marie, Harris, Margaret, Lim, Zhi Ying, Spring, Rebecca, Stieler, Melissa, Barnes, Nicholas Adamson, Alam, Ahmad Seraj, Alsoudani, Ali, Amico, Francesco, Anning, Rebecca, Balogh, Zsolt J., Blatt, Alison, Cairns, Scott, Carroll, Jesse, Caterson, Andrew, Christie, Adam, Cope, Daron, Dale, Tyson, Dennis, Grace, Duggal, Anchal, Ennis, Brendan, Fenton, Mark, Yi Xin Joanna, Fu, Galevska‐dimitrovska, Ana, Gani, Jonathan, Gelzinnis, Scott, Gramlick, Madelyn, Hadlow, Claudia, Hardstaff, Ruth, Heer, Munish, Holmes, Merran, Hone, Bridget, Sophie, Hu, Huang, Linna, Iqbal, Ramiz, Jefferson, Niall, Kasthurirathne, Dimithi, Kuo, Stephen, Lau, Wayne Yan, Liang, Hsin‐ping, Lim, Daniel, Lin, Rosalina, Mcdonogh, Jack, Mcilwain, Elysse, Ming, Yan Joyce, O’Neill, Christine, Ocsan, Ryan James, Oosthuizen, Benjamin, Organ, Nicole, Otieno, James, Park, Felicity, Paterson, Amanda, Cerdeira, Marisol Perez, Peters, Luke, Petersson, Josefin, Rubbo, Sonia, Siribaddana, Venesa, Thurairajah, Kabilan, Ting, Caleb, Watson, Antonia, Way, Teagan, Wiadji, Elvina, Willoughby, Ellisha, Bailey, Ashley, Broadbent, Samuel, Narayanan, Viswanathan, Stephens, Samuel, Wilkes, Anna, Zhao, Jie, Ballal, Mohammed, D’Souza, Carl, Forbes, Clara, Goss, Matthew, Haddleton, Monique, Harty, Jacinda, Hayne, Dickon, Hew, Nicole, Koh, Wee Ling, Lee, Shawn, Malik, Shahbaz S, Abdul, Naseer Mohammed, Richards, Toby, Seow, Yi Th Ng, Wong, James, Archer, Leigh, Azaman, Nur Sabrina Binti Babe, Dilevska, Tina, Foo, Jonathan, Hans, Tasvinder, Jansen, Shirley, Kumar, Mohit, Leeson, Christopher, Pham, Terence, Pineda, Fernando Picazo, Rajakumar, Saravanan, Suk‐udom, Supisara, Tan, Jonathan, Thurston, Benjamin, Zhao, Bichen, Gupta, Shivangi, Hou, Lachlan, Jeyamanoharan, Nivedan, Leigh, James, Poh, Wei Shearn, Sala, Michael, Crothers, Rebecca, Dravid, Madhulika, Harrison, Ben, Islam, Sumayya, Mccartney, Conor, Nel, Henco, Pearson, Natasha, Apostolou, Christos, Berney, Christophe, Chou, Richard, Hanna, Sam, Lam, Andrew, Vanessa, Ma, Phanse, Salonee Shubhen, Elliott, Michael, Phung, Daniel, Barry, Jessica, Clark‐mackay, Eleanore, Cope, Jennifer, Halliwell, Richard, Chen, Ji, De Robles, Marie Shella, Llorando, Alyssa, Mahin, Humaira Haider, Rao, Dominic, Syed, Faisal, Abulafia, Daniel, Buckland, Benjamin, Cordingley, Timothy, Debiasio, Ashe, Drane, Andrew, Ireland, Patrick, Julien, Benji, Lan‐hoa, Le, Lee, Austin Yeon Suk, Loh, Eu Jhin, Middleton, Andrew, Mortimer, Brienna, Sebastian, Samuel, Short, Brooke, Stewart, Peter, Ruyven, Stephanie, Wong, Daniel, Zhang, Charry, Zhu, Bonnie, Ziaziaris, William, Leitner, Aran, Tolzman, Lukas, Zitt, Matthias, Rakos, Gergely, Székely, György, Djedovic, Gabriel, Königsrainer, Ingmar, Allmer, Caterina, Herritsch, Barbara, Mitteregger, Martin, Schauer, Christian, Seitinger, Gerald, Siebenhofer, Carmen, Uranitsch, Stefan, Duller, David, Mathew, Erwin, Skias, Christoph, Andrianakis, Alexandros, Belarmino, Armin, Brinskelle, Petra, Castellani, Christoph, Cohnert, Tina, Fediuk, Melanie, Fink, Andrea, Holzmeister, Clemens, Kahn, Judith, Kresic, Josip, Leithner, Andreas, Lindenmann, Joerg, Lumenta, David, Michelitsch, Birgit, Mikalauskas, Saulius, Nischwitz, Sebastian P., Puchwein, Paul, Roj, Andrej, Schemmer, Peter, Singer, Georg, Smolle‐juettner, Freyja‐maria, Till, Holger, Wolf, Axel, Andraschofsky, Tibor Oliver, Angerer, Rafael, Arco, Daniel, Kaufmann, Claudia, Kilic, Nura, Widschwendter, Peter, Angermann, Reinhard, Bauer, Marlies, Bergmann, Nicole, Freyschlag, Christian, Gisinger, Martin, Gollmann‐tepeköylü, Can, Graber, Michael, Haim, Alexander, Harasser, Carina, Härter, Bettina, Hirsch, Jakob, Hofer, Markus, Holfeld, Johannes, Huber, Anna Lena, Kralinger, Martina, Krappinger, Dietmar, Kuen, Marlene, Liebensteiner, Michael, Messner, Franka, Messner, Alex, Naegele, Felix, Ninkovic, Marijana, Nowosielski, Yvonne, Osl, Antonia, Ower, Cornelia, Pölzl, Leo, Rauchegger, Teresa, Reimer, Daniel, Riecke, Johannes, Schwabegger, Anton H., Sokolovski, Filipp, Strimmer, Anna, Süss, Markus, Thaler, Martin, Umlauft, Julian, Zehetner, Claus, Zeimet, Alain G., Allerstorfer, Jakob, Haslhofer, David, Hofer, Daniel, Luger, Matthias, Pisecky, Lorenz, Poier, Nikolaus, Rubicz, Nina, Schmolmüller, Christoph, Zwittag, Paul, Rossmann, Tobias, Ruiz‐navarro, Francisco, Stefanits, Harald, Elsayed, Hend, Habertheuer, Peter, Hajkova, Tereza, Loidl, Wolfgang, Luger, Ferdinand, Windischbauer, Amadeus, Fischer, Ines, Függer, Reinhold, Kirchweger, Patrick, Saini, Thomas, Berger, Julian, Fraz, Wolfgang, Nia, Arastoo, Kenez, Mihaly, Nichita, Margit, Magele, Astrid, Mayr, Thomas, Noe, Chiara, Bittner, Reinhard, Borhanian, Kurosch, Dornauer, Isabella, Emmanuel, Klaus, Gabersek, Ana, Gantschnigg, Antonia, Grechenig, Michael, Gruber, Ricarda, Hutter, Jörg, Jäger, Tarkan, Koch, Oliver, Lechner, Michael, Manzenreiter, Lisa, Mayer, Franz, Muehlbacher, Iris, Presl, Jaroslav, Rezaie, Daniel, Schredl, Philipp, Varga, Martin, Weitzendorfer, Michael, Wimmer, Angela, Brunner, Eberhard, Cillia, Michael, Gruber, Michaela, Grünbart, Martin, Heinrich, Elmar, Hoi, Hannes, Kemmetinger, Vanessa, Mittermair, Christof, Mosshammer, Victoria, Obrist, Christian, Paal, Peter, Roesch, Judith, Russe, Elisabeth, Schaetz, Tobias, Schirnhofer, Jan, Schwaiger, Karl, Wechselberger, Gottfried, Weiss, Helmut, Lanner, Maximilian, Binder, Alf‐dorian, Gürtler, Thomas, Fink, Marcus, Reichhold, Daniel, Stoyanova, Radoslava, Beitl, Klara, Bernardi, Martin H., Datler, Philip, Dawoud, Christopher, Farr, Alex, Foessleitner, Philipp, Grimm, Christoph, Harpain, Felix, Hoda, Mir Alireza, Holawe, Simone, Kranawetter, Marlene, Ott, Johannes, Perricos, Alexandra, Pesta, Maximilian, Pillerstorff, Robert, Reiterer, Christian, Riss, Stefan, Rosta, Klara, Scheriau, Georg, Tschernko, Edda, Wenzl, Rene, Wiedemann, Dominik, Wohlrab, Peter, Zapletal, Bernhard, Zimmermann, Matthias, Zimpfer, Daniel, Findl, Oliver, Fisus, Andreea, Ruiss, Manuel, Komaz, Melanie, Meindl, Nikolaus, Primavesi, Florian, Stadlbauer, Karl Heinz, Stättner, Stefan, Steiner, Florian, Cerny, Ondrej, Falkensammer, Eva, Knotzer, Hans, Köglberger, Paul, Poidinger, Bernhard, Wiesinger, Clemens Georg, Burtscher, Johannes, Rath, Sebastian, Trivik‐barrientos, Felipe, Aliyeva, Gunay, Behbudov, Vuqar, Muslumov, Gurbankhan, Zeynalov, Natiq, Alam, Mahmood, Alfayez, Fatema, Hasan, Batool, Mahdi, Maryam, Mulla, Husain, Qader, Kawthar, Saeed, Amr, Shirazi, Ahmed, Albastaki, Aysha, Birido, Nuha, Chagla, Hiba Hameed, Dawaishan, Abdulla, Dawaishan, Baheya, Farhan, Abeer, Juma, Isam, Khan, Asher, Patel, Aqsa Mohammad Eqbal, Srinivasan, Madhu, Deen, Fatema Waheed Akbar Mohamad Akbar Nawab, Abdulqadir, Seemal, Jabr, Abdulla, Maqsood, Fauzia, Almoosa, Noora, Naseer, Mai, Alam, Mohammed Shadrul, Basher, AKM Khairul, Islam, Shahnoor, Islam, S. M. Nazmul, Karim, Sabbir, Faisel, Muntasir, Khan, Sadia, Mannan, Iftekhar Ibne, Nazia, Nawshin, Bentham, Malissa, Corbin, Sasha, Doyle, Alex, Eastmond, Asha, Haynes, Amelia, O’Shea, Margaret, Phillips, Emil, Walkes, Keisha, Artyushkov, Evgeniy L., Kaplan, Mark L., Straltsov, Vladislav, Litvina, Yauheniya, Lyzikov, Alexei, Tihmanovich, Victor E., Borges, Mafalda, Brits, Tim, De Hous, Nicolas, De Wachter, Stefan, Menovsky, Tomas, Mortiers, Xavier, Vermeulen, Dorien, Vleminckx, Nils, Ysebaert, Dirk, Bontinck, Julie, Bulthé, Danny, Rasschaert, Ricky, Van Haver, Anne‐sophie, Van Belle, Koen, Verstraeten, Laurence, Vounckx, Manon, D’Ulisse, Sébastien, De Bruyne, Yasmine, El Nakadi, Badih, Heloise, Tessely, Luisetto, Matteo, Marinakis, Sotirios, Maton, Maxime, Viste, Claire, Van Daele, Elke, Vandeputte, Mathieu, Duinslaeger, Marc, Jacobs‐tulleneers‐thevissen, Daniel, Jansen, Yanina, Janssens, Ward, Kunda, Rastislav, Messaoudi, Nouredin, Ruyssers, Michael, Van Eetvelde, Ellen, Vanhoeij, Marian, Van den Eynde, Jef, Van den Eynde, Raf, Chaoui, Ahmed M., Akpla, Marcellin, Lawani, Souliath, Agossou, Hermann, Behanzin, Hulrich Aouagbe, Bokossa, Covalic, Dewanon, Hubert, Yome, Hugues, Boukari, Alassan, Gbehade, Oswald, Tobome, Sèmèvo Romaric, Amossou, Labissi Francois, Dossou, Francis, Barišić, Tatjana, Boras, Miran, Brekalo, Zdrinko, Blagojević, Ivana Čuljak, Damjanović, Ana, Dragisic, Vedran, Šimić, Ana Dugandžić, Gunaric, Filip, Kajic, Martin, Knežević, Darko, Krešić, Tanja, Lasić, Valentina, Letica, Ludvig, Martinovic, Vlatka, Mikulic, Iva, Miskovic, Josip, Pehar, Hrvoje, Rastović, Pejana, Sesar, Irena, Šetka‐čuljak, Violeta, Soljic, Martina, Tiric, Dejan, Tomić, Vajdana, Vasilj, Anja, Hudic, Igor, Oliver, Renato Aguera, Lamonica, Felipe Azenha, De Medeiros, Jorge, Florindo, Henrique Donizetti Bianchi, Filho, Rodolfo Jose Favaretto, Pereira, Fernanda Costa, Rodrigues, Rodrigo, Junior, Antonio Antunes Rodrigues, Andrade, Fernanda Ruiz, Salvetti, Maisa, Campioto, Débora Schalge, Lamonica, Mayra Tuboi, Urbano, Gustavo, Prado, Ricardo Villela, Alonso, Nivaldo, Santos, Carlos Ferreira, Tonello, Cristiano, Pires, Robinson Esteves, Rezende, Ricardo Fernandes, Reis, Igor, Marson, Fernando Augusto Lima, Ferreira, Erick Pires, Palamim, Camila Vantini Capasso, Brandao, Marcelo, Souza, Tiago Henrique, Maunsell, Rebecca, Neto, Alfeu Accorsi, Accorsi, Guilherme, Fernandes, Murilo Francisco, Machareth, Camila, Moura, Barbara Viegas, Dias, Vanessa, Guarienti, Luciano, Sampaio, Lia Regina, Vendrame, Cristiano, Coelho, Tatiane Amorim, Becker, Karin, Dias, Andre, Fachin, Camila Girardi, Gomes‐da‐silva, Monica Maria, Moraes, Isabela, Pinto, Amanda, Stychnicki, Adriano Seikiti, Julio, Nathalia Siqueira, Santos, José Mauro, Junior, Humberto Fenner Lyra, Oliveira, João Carlos Costa, Onzi, Tiago Rafael, Gerber, Marlus Tavares, Coelho, Filipe Osni, Silva, Janaína Carla, Panis, Carolina, Rech, Daniel, Avelino, Melissa, Botacin, Lais, Gonçalves, Mateus Capuzzo, Santos Leite, Amanda Lira, Pol‐fachin, Laercio, Bezerra, Tainá Santos, Santos Junior Alcimar, Alcimar Lavareda, Amorim, Robson, Leão, Maria Eduarda Bellotti, Bergamasco, João José Corrêa, Pinheiro, Cintia Cardoso, Neto, Rubem Alves Da Silva, De Araújo, Elaine Francisca, Guimaraes, Lilian, Liborio‐kimura, Tatiana, Camara, Isabelle Melo, Siqueira, Victor Ripardo, Rodriguez, Juan, Silva, Jeancarllo, Junior, Rubem Alves Silva, Cardoso, Cláudio, Guimaraes, Andre, Alves, Wislene Sarajane Moreira, Menezes, Agna Soares Da Silva, Araujo, Marcelo, Brito, Kattiucy, Albuquerque, Josie Marcelle Lira, Dussan‐sarria, Jairo Alberto, Souza, Andressa, Stüker, Andre Ricardo, Bresciani, Tiago, Stefani, Luciana Cadore, Cavazzola, Leandro Totti, Costa, Tainá, Dasqueve, Matheus, Marangon, Gustavo De Bacco, Martins, Otávio Ritter Silveira, Rodrigues, Josy, Cardoso, Guilherme Roloff, Neto, Brasil Silva, Soares, Tilaê, Zanella, Aline, Filippi, Lucas Torelly, Guerra, Enilde Eloena, Cruz, Ricardo Pedrini, Kalil, Antonio Nocchi, Laporte, Gustavo, Salem, Moacyr, Lima Brazan, Murilo, Campos Prado, Caio Antonio, Moises, Elaine Christine Dantas, Suto, Hilda Satie, Yasuda, Alice Gadotti, Zani, Ana Carolina Tagliatti, Santos, Roberto Cardoso Cardoso, Duarte, Geraldo, Joviliano, Edwaldo Edner, Santos, Carolina Lourenço Gomes, Quintana, Silvana Maria, Tamashiro, Edwin, Valera, Fabiana Cardoso Pereira, Zaccaro, Marília Veccechi Bijos, Andreotti, Isis, Lima, Leonardo, Salgado, Wilson, Cunha Viana Júnior, Alonço, Moutinho, Lana, Oliveira, Cora Pichler, Martins, Isabela Trindade, Toledo, Isabela Vieira, Guimaraes‐filho, Marco Antonio Correa, Arrivabeno, Rodrigo, Murta, Claudio Bovolenta, Said, Danniel Frade, Junior, Jose Pontes, Pugliesi, Felipe Guimarães, Gregorio, Paulo, Mariani, Alessandro, Minamoto, Fabio, Silva, Juliana Lourenço, Muller, Bruno, Zanon, Caio, Carvalho, Vladimir C., Lima, Ana Lucia Munhoz, Oliveira, Priscila R, Santos Silva, Jorge, Teixeira, Mariana Faccini, Kulcsar, Marco, Matos, Leandro, Nunes, Kamilla Schmitz, Junior, Joel Abdala, Abdallah, Emne, Carvalho, Genival Barbosa, Farias, Igor Correia, Silva, Cassia, Eloi Pinto, Fabio Fernando, Facure, Luciana, Godoy, André, Kupper, Bruna, Leite, Fernanda, Melo Lôbo, Matheus, Mantoan, Henrique, Marques, Narimã, Marques, Tomas, Medici, João Paulo, Torres, Silvio Melo, Garcia, Katheryne Merlos, Meduna, Rafael Ribeiro, Herbst, Ana Carolina Scintini, Santos, Silvana Soares Dos, Gonçalves, Bruna Tirapelli, Antonini, Marcelo, Brienze, Carolina, Farah, José Francisco, Gonçalves, Rodrigo, Machado, Vinicius, Nadal, Luis Roberto, Rodrigues, Danilo Nadal, Pansani, Adrieli, Rocha, Maria Luiza, Simonsen, Marcelo, Tsuchiya, Daniela, Vasques, Rafaela, Amorim, Jorge, Carvalho, Ana Alyra, Correia, Rebeca, Santos, Brena Costa, Neto, Henrique Jorge Guedes, Nakano, Luis, Pereda, Mariana, Vasconcelos, Vladimir, Awada, Jamile Barakat, Gava, Guilherme, Ijichi, Tiago Riuji, Kim, Nam Jin, Nunes, Rafael, Pinto, Fabio, Pereira, Thiago Henrique Sigoli, Volpe, Gustavo Jardim, Gatti, Arthur, Nardi, Caroline, Oliva, Ramon, Oliveira, Layze Braz, Carvalho, Herica Emilia Félix, Ribeiro, Ivonizete Pires, Rodrigues, Gabriel Renan Soares, Sousa, álvaro Francisco Lopes, Chebel, Michel, Sousa Fernandes, Paulo Henrique, Freitas, Marcelo Augusto Faria, Cunha, Juliano Rodrigues, Ather, Zeenia, Dimitrov, Dobromir, Filipov, Emil, Gyokova, Elitsa, Ilieva, Ivelina, Ivanov, Tsvetomir, Karamanliev, Martin, Neykov, Vasil, Atanasov, Boyko, Belev, Nikolay, Kamenova, Paolina, Tonev, Kaloyan, Yotsov, Tsanko, Hristova, Evguenia, Spassov, Kolyo, Tsankov, Tsanko, Dardanov, Dragomir, Gribnev, Petar, Sokolov, Manol, Brown, James, Tanyi, John, Hurdle, Heather, Maclean, Anthony, Sander, Michael, Al Riyami, Salim, Bali, Krittika, Bigam, David, Dajani, Khaled, Anvari, Mehran, Bolis, Rafik, Choi, David, Ellis, Susan, Gupta, Michael, Hanna, Wael, Hong, Dennis, Horner, Cynthia, Luketic, Lea, Moisiuk, Peter, Shargall, Yaron, Alfaro, Hilda, Alkhamesi, Nawar, Allen, Laura, Brackstone, Muriel, Chan, Eunice, Cheng, Davy, Chui, Jason, Gonzalez, Nelson, Lanting, Brent, Macneil, S. Danielle, Mayer, Robert, Mcgee, Jacob, Nagappa, Mahesh, Power, Nicholas, Prempeh, Agya, Qiabi, Mehdi, Razvi, Hassan, Schemitsch, Emil, Sehmbi, Herman, Shah, Ushma, Subramani, Yamini, Vasarhelyi, Edward, Vogt, Kelly, Yang, Homer, Abdehgah, Ali Ghorbani, Balvardi, Saba, Feldman, Liane, Fiore, Julio Flavio, Hanson, Melissa, Hopkins, Brent, Kaneva, Pepa, Lee, Lawrence, Leonard, Julia, Abou‐khalil, Jad, Martel, Andre, Stevenson, James, Lee, Susan, Merchant, Richard, Avoine, Samuel, Belanger, Laurence, Belanger, Mathieu, Belzile, Etienne, Blais, Anne‐sophie, Boucher‐kovalik, Sofia, Boulanger‐gobeil, Cindy, Cardinal, Etienne, Champagne, Pierre‐olivier, Cloutier, Jonathan, Corriveau‐durand, Simon, Cote, Mathieu, Cote, Maxime, Côté, Mathilde, Courval, Valérie, Demers, Suzanne, Desbiens, Christine, El Ouazzani, Mehdi, Girard, Karine, Girard, Ève‐marie, Gosselin, Karo, Khuong, Helene, Labrecque, Nathalie, Langlais, Eve‐lyne, Larouche, Audrey, Lavallée, Andréane, Lemyre, Madeleine, Maheux‐lacroix, Sarah, Marien, Melissa, Marin, Patrick, Mauger, Julie, Milot, Genevieve, Nadeau, Sylvie, Nguyen, Sebastien, Paris, Mélinda, Pelet, Stéphane, Plante, Marie, Plante, Carole, Pouliot, Frederic, Renaud, Marie Claude, Sarlabous, Mathilde, Schmit, Isabelle, St‐germain, Raphaël, Johnston, Brian, Labine, Nicole, Persad, Amit, Pham, Hong, Wood, Melissa, Azam, Riordan, Atrey, Amit, Beckett, Andrew, Cohen, Daniel, Das, Sunit, Daza, Julian, Dunkerton, Cheryl, Ellenbogen, Yosef, Hanley, Ciara, Kellett, Sorcha, Khoshbin, Amir, Ladha, Karim, Mcfarlan, Amanda, Montgomery, Spencer, Pazmino‐canizares, Janneth, Suresh, Hrishikesh, Vasdev, Ravleen, Ahmed, Maira, Gentili, Fred, Kalyvas, Aristotelis, Millesi, Matthias, Sarica, Can, Shaikh, Taariq, Leslie, St, Jacques, Null, Tabasinejad, Raha, Zadeh, Gelareh, Hsiao, Marvin, Jedrzejko, Nicole, Black, Peter, Broe, Claire, Dandurand, Charlotte, Grey, Rebecca, Leung, Philemon, Lindberg, Andrew, Gutierrez, Juan Mata, Mayson, Kelly, Meneghetti, Adam, Phillips, Drew, Street, John, Calderón, Carolina Carvajal, Pizarro, Daniel Alejandro Donoso, Fernández, Esteban, Molero, Ángela, Mutarello, Nastassja, Lucic, Jorge Núñez, Gaete, Katherine Ochoa, Lopez, Catalina Ruiz, Sepúlveda, Rina, Ulloa, Camila, Barreda, Mauricio, Dallaserra, Matias, Wood, Matías Günther, Tobar, Mauricio Sandoval, Garcia‐huidobro, Francisco, Dona, Jimena, Diez, Carolina Soto, Igor, Daniel, Mena, Javier, Reyes, José Tomás, Soto, Catalina Arredondo, Campos, Jose, Gonzalez, Javier, Rivera, Barbara, Altamirano‐villarroel, Jaime, Cohn, David, Amesti, Luis Marin, Recabal, Pedro, Sandoval, Camilo, Fonseca, Bruno Catoia, Contador, Monica, Hodali, Andres, Pincheira, Camila, Mantilla, Andrea Ramos, Garrido, Claudio Salas, Torres, Janina, Valenzuela, Marco, Chen, Zehua, Jiankun, Hu, Tao, Jin, Yang, Kun, Zhang, Yuexin, Chen, Yuan, Cunchuan, Wang, Yang, Wah, Bai, Xueli, Liang, Tingbo, Tao, Ma, Ning, Pu, Yin, Hanlin, Caicedo, Camilo, Beltran, Diego Felipe Tellez, Escobar, Alejandro, Granados, Carolina Perez, Pinzon, Lisbeth Alexandra Urueña, Bonilla, Carlos, Santana, Diana, Serrano, Oscar, Garcia, Andrea, Luque, Fernando Giron, Patino‐jaramillo, Nasly G., Baquero, Laura Giselle Contreras, Botero, Nestor Augusto Muñoz, Castellanos, Jhoana Andrea Murillo, Calvera, Andrea Juliana Vega, Acosta Buitrago, Lina M., Bohórquez‐tarazona, Maria Paz, Rivera, Paulo Andrés Cabrera, Felipe Casas, J, Alfaro, Valeria Cormane, Corso, Julian, Guerra, Bayron, Guerrero‐becerra, Albert Franz, Abiyomaa, Akram Kadamani, Montes, Felix Ramon, Paz, Manuel Santiago Mosquera, Sandoval, Camilo Andrés Polanía, Quintana, Natalia, Ortega, Carlos Fernando Roman, Santacruz, Carlos, Téllez, Manuela, Sánchez, Camilo Alejandro Velandia, Arias‐amézquita, Fernando, Vargas, Luis Felipe Cabrera, Murgueitio, Natalia Cortes, Escorcia, Elkin, Ghotme, Kemel Ahmed Ghotme, Gomez‐mayorga, Jorge Luis, Vergel, Alvaro Felipe Guerrero, Herrera‐almario, Gabriel, Londono‐schimmer, Eduardo, Mejia, Juan A., Monsalve, Guillermo, Rodriguez, Camilo, Niño, Juan Nicolas Rodriguez, Ortegón, Luis Martín Rodríguez, Sanabria, Daniel, Alvarez, Andres, Andrade, Arnulfo, Ardila‐montealegre, Javier, Baquero, David, Vidales, Edgar Mauricio Barrios, Giraldo, María Alejandra Caicedo, Carvajal, María Camila, Castillo, Maria, Florez, Maria Carolina Castillo, Cendales, María Angelica, Monroy, Danny Conde, Cortes, Henry, Daniel, Mario, De la Peña, Jairo, Delgado‐nieto, Elena Leonor, Espitia, Hernando, Avendaño, Carlos Figueroa, Burgos, Edgar Oswaldo Hernandez, Isaza‐restrepo, Andres, Londono, German, Maldonado, Margarita Maria, Montenegro, Andrea, Navarro, Juan Carlos, Navarro‐alean, Jorge, Abaunza, Katherine Parra, Pulido, Eliana, Ramírez Amaya, Erika M., Chaves, Carlos Eduardo Rey, Rincón, Natalia Andrea Rivera, Castillo, William Mauricio Riveros, Sanchez, Lizeth Rodriguez, Rubiano, Wilson, Russi, Maria, Olarte, Juan Carlos Sabogal, Tovar, Javier Mauricio Salgado, Sanchez, Maria Juliana, Varela, David Mauricio Solano, Gomez, Paula Torres, Trillos, Marcial, Patiño, Ana María Vargas, Vargas‐barato, Felipe, Leon, Juan Pablo Villate, Useche, María Alejandra Wagner, Acosta, Jesus, Almeciga, Adriana, Mendez, Luis Becerra, Beltran, Rafael Jose, Bonilla, Ana, Buitrago, Miguel, Cabrera, Marino, Quiroz, Pedro Hernando Calderon, Camacho‐nieto, Diego, Fierro, Carlos Andrés Carvajal, Bonilla, Sergio Cervera, Diaz, Sandra, Facundo, Helena, Forero, Jorge, Mora, Mauricio Garcia, Tirado, Karena Victoria Garcia, Perez, German Fabian Godoy, Gonzalez, Felipe, Guevara, Oscar, Hernandez, Jairo Alonso, Mora, David Ricardo Herrera, Lalinde, Juan David, Lehmann, Carlos, Llanos, Eduardo Leon, Lopez, Byron Eduardo Lopez De Mesa, Mariño, Ivan, Medina, Monica, Morales, Raúl Eduardo Pinilla, Puerto, Angela, Null, Ma, Quintero‐ortíz, Andrea, Hernández, Juliana Rendón, Cortés, Elio Fabio Sánchez, Hernández, Alvaro Eduardo Sánchez, Suarez, Raul, Suescun, Oscar, Vanegas, Marco, Varela, Rodolfo, Bernal, Jorge Luis Velez, Viveros‐carreño, David, Gómez, Daniela Camargo, Fletcher, Angelica, Merchan, Abel, Luna, Euler Javier Burbano, Cujiño, Indira, Galvis, Mauricio Velasquez, Galliadi, Lina Maria Vergara, Gonzalez, Orlando Abonia Gonzalez Abonia, Saravia, Maria Fernanda Acuna, Arroyave, Roberto, Angulo, Jose Maria Barreto, Bonilla‐escobar, Francisco Javier, Cardona, Uriel, Giacometto, Ivan Castañeda, Castillo, José Luis, Castillo‐cobaleda, Diego Fernando, Garcia, Diego Jose Caycedo, Tello, Brenda Marcela Coll, Dueñas‐ramirez, Juan Carlos, Vidarte, Oscar Andres Escobar, Figueroa, Luis, Garcia‐perdomo, Herney, Gomez, Alden, Gomez, Laura, Gomez, Alejandro, Grande‐gil, Ana María, Guarin, David, Guzman, Natalia, Castañeda, Enrique Herrera, Hinaoui, Marisol, Escobar, Anuar Armando Idrobo, Kammerer, Christian Kammerer, Leon, Sergio, Lucero, Carlos Antonio Llanos, López, Angie, Martinez‐blanco, Alexander Maximiliano, Casella, Antonio José Montoya, Corredor, Ricardo Andres Niño, Ordoñez, Sebastian, Uribe, Diego Alfredo Palta, Serna, Andrea Carolina Perea, Ríos, July, Ríos‐samper, Gabriel, Garcia, Juan David Rivera, Moreno, Juan Camilo Salcedo, Sandoval, John, Ramirez, Guillermo Alberto Sarmiento, Romero, Paola Andrea Tabares, Urzola, Ricardo, Valdes‐duque, Iliana Maria, Velasquez, Miguel, Villegas, Lina Maria, Zapata‐copete, James, Lara, José Omar Zorrilla, Zuluaga, Mauricio Zuluaga, Moreno, Alejandra Echeverri, Figueroa, Juan Sebastian, Ortiz, Adolfo Enrique Gómez, Mosos, Maria Fernanda Gonzalez, González‐orozco, Alejandro, Roncancio, Juan Jose Jaramillo, Martínez, María Camila Leyva, Mosos, Monica, Ramirez, Juan Sebastian, Rodríguez, Henry Andrés, Henao, Juan David Saavedra, Varón, María Alejandra Torrado, Ramírez, Leidy Natalia Idarraga, Ocampo, Lorena, Marin, Monica Cardona, Gonzalez, Ana Maria Marin, Mejia, David Alejandro, Vanegas, Luis Emiro, Martinez, Yicel Alvarez, Vesga, Sandra Aruachan, Fuentes, Dayana Vanessa Baron, Salas, Alejandra Caballero, Estrada, Gustavo Antonio Martinez, Campo, Kelly Viloria, Alvarez, Juan Antonio Corralez, Regino, Cesar David Galindo, Velasquez, Angela Maria Giraldo, Moreno, Carlos Enrique Melo, Tejada, Jorman H., Tovar, Jesus Hernan, Tovar, German Alirio, Hernández, Edison Alexander Benavides, Orozco‐chamorro, Claudia Milena, Angel, Gustavo Adolfo, Buesaquillo, Christian Ali, Montaño, Victor David Olave, Sánchez‐gómez, Andrés, Ureche, Daniela Patricia Escalante, Garrido, Jairo Martinez, Genda, Eben‐ezer, Eboma, Fabrice, Bitunjac, Kristina, Grulović, Karlo, Vučković, Marijana, Šantak, Goran, Borovic, Emanuel, Versic, Ana Bosak, Hasandić, Damir, Grabar, Natasa Poldan, Medancic, Suzana Srsen, Brkic, Lucija, Cokarić, Sara, Palac, Petra Pavic, Samac, Zeljka, Tomić, Josipa, Vrdoljak, Marija, Bacic, Ivan, Bakmaz, Bernarda, Vučičić, Nikolina Bratošević, Brzic, Domagoj, Canovic, Samir, Dijan, Emilio, Dragicevic, Maja Grgec, Karlo, Robert, Konjevoda, Suzana, Kovačević, Petra, Kovačić, Ivan, Markulić, Frane, Matak, Luka, Morović, Domagoj, Perišić, Gordan, Simic, Andrea, Skitarelić, Neven, Veršić, Matea, Žufić, Vanja, Zuzul, Matea, Anzic, Srdan Ante, Carevic, Iva, Litvic, Dubravka Heli, Markov‐glavas, Duska, Jovanovic, Tatjana Savic, Augustin, Goran, Biloš, Jerko, Biočina, Bojan, Biosic, Vedrana, Bobovec, Dino, Botica, Iva, Bumber, Boris, Čerina, Petra, Vukovic, Katarina Duric, Gasparovic, Hrvoje, Gatin, Lucija, Grsic, Kresimir, Radojković, Ika Gugić, Jelčić, Ivan, Kastelan, Zeljko, Kolak, Juraj, Kulis, Tomislav, Kunjko, Kristian, Maric, Marjan, Kavanagh, Marcel Marjanović, Milicic, Borna, Morić, Trpimir, Pasini, Miram, Penezić, Luka, Prgomet, Drago, Prstacic, Ratko, Prtorić, Andreja, Radojković, Rudolf, Romić, Ivan, Sečan, Tomislav, Šoša, Dora škrljak, Slipac, Juraj, Tomic, Mislav, Zedelj, Jurica, Zekulić, Toni, Zimak, Zoran, Lorencin, Mia, Luksic, Ivica, Mamic, Matija, Espinsa, Norberto Miranda, Cruz, Ailén Sánchez, Antoniou, Stavros A., Kakas, Michael, Panayiotou, Yiannis, Almezghwi, Heyam, Arslan, Kalbim, Besim, Hasan, Özant, Ali, Özçay, Necdet, Kokkinos, Georgios, Papatheodorou, Panayiotis, Pozotou, Ioanna, Stavrinidou, Olga, Yiallourou, Anneza, Burda, Lukáš, Dosoudil, Michal, Martinek, Lubomir, Gawel, Wladyslaw B., Lerch, Milan, Peteja, Matúš, Žatecký, Jan, Daniel, Toman, Formánek, Martin, Javurkova, Veronika, Kepičová, Markéta, Macečková, Nicole, Matousek, Petr, Simetka, Ondrej, Vavra, Petr, Zelenik, Karol, Černý, Jan, Khan, Sami, Lischke, Robert, Přibyl, Martin, Younus, Temoore, Amarasena, Yenuksha, Klíma, Karel, Pirmorad, Setareh, Hotová, Zuzana, Mladěnka, Aleš, Bozo, Nulvin, Harbjerg, Julie Lykke, Hviid, Louise, Kristensen, Helle ø, Mekhael, Mira, Nielsen, Mette Fugleberg, Paulsen, Laerke, Sinimäki, Saija, Mogensen, Louise Zinck, Bonde, Peter, Ebbehøj, Anders Lyng, Fenger, Anne‐sophie, Haugstvedt, Aleksander Fjeld, Hansen, Christine Hangaard, Jönsson, Maria Lovisa, Jorgensen, Lars N, Krarup, Peter‐martin, Lihn, Anne‐louise, Meyhoff, Christian, Otte, Helena, Amar, Anas Ould Si, Palm, Henrik, Schlesinger, Nis, Smith, Henry, Tryggedsson, Ida, Axelsen, Anne Reiss, Bælum, Jens Kristian, Ellebaek, Mark Bremholm, Ellebæk, Signe Bremholm, Hogh, Anders, Acosta, Maria, Acosta, Yancy, Baez, Pedro, Betances, Luis Alfredo, Bonilla, Luis Rodolfo, Cabreja, Daniel, Cruz, Wilton Cabrera, Expósito, María Mabel Collado, Crespo, Aldo, Cruz‐pineda, Octavio, D’óleo García, Claudio Samuel, Díaz, Pedro, Escoto, Remberto, Figueroa, Jatnna, Garcia, Luis, Rodriguez, U Garcia‐Dubus, Gomez, Humberto, Grullon, Adrian, Guerrero, Fatherin, Guzman, Lillian, Mosquea, Thelma Rocío Jiménez, Lazala, Engels, Lopez, Ariela, Francisco, Leeany Maletta, Mercado, Jhomayri, Munoz, Herisardy, Paulino, Jeffrey, Fernandez, Maricely Ambar Perez, Reyes, Rudeily, Guilamo, Lilia Rosa Reyes, Rivas, Ruben, Torres, Claudia Alejandra Rivas, Rodríguez, Ada, Villa, Madelin Tamar Rosario, Santana, Eleazar, Soto, Joel, Tactuk, Nassin, Sardiñas, Cristina Kristel Tonos, Ubinas, Raul, Victoria, Jose, Villegas, Aaron, Acra‐tolari, Ricardo, Beltran, Larissa, Betances, Luis Fernand, Blaubach, Alejandro, Mejía, Denisse Idalia Campos, Capellan, Nathalia, Bruzual, María Fernanda Cedeño, Spencer, Saray Cordero, Lantigua, Gabriella Cuevas, De Jesus, Luis, Díaz, Gabriela, Vásquez, Pedro Pablo Díaz, Disla, Karla, Uceta, Jesús Antonio Echavarría, Jimenez, Paola Irina Eusebio, Fernandez, Damaris, Camilo, Marlin Fernandez, Germosen, Jiomar Manuel Figueroa, Fortunato, Maruel, Fernández, Leyla Gabriel, Dihmes, Alicia German, Herrera, Héctor, Cuevas, Elizabeth Leon, Mata, Jose Alejandro, De La Cruz, Mirian Mateo, De la Cruz, Dolores Mejia, Mirambeaux, Marcos, De La Cruz, Fabio Ortiz, Paulino, Henry, Pelletier, Gabriela, Pichardo, Merycarla, Enrique, Rodriguez Pumarol Próspero, Rivas, Julio, Marmolejos, Ann Stephany Sanchez, Santana, Roman Santana, Almanzar, Irina Suero, Sánchez, María Magdalena Vásquez, Campuzano, Nicolás, Ocampo, José Ricardo Negrete, Armas, Maria, Guerra, Alvaro Santiago LeMarie, Vizcaya, Gustavo León, Abdelwahab, Omar Ahmed, Elmehrath, Ahmed O., Mostafa, Mohammed Ezzat, Amira, Gamal, Sallam, Ibrahim, Sherief, Mohamed, Abdelmajeed, Ahmed, Abdou, Mostafa, Shanab, Ahmed Abo, Abodeeb, Aya, Aboelkhel, Roger, Abosamak, Nour Eldin, Bakr, Amna Abou, Aboubakr, Samar, Abouelnagah, Yossof, Aboumadawy, Omar, Adel, Dina, Afifi, Nermeen, Ahmed, Sara, Ahmed, Abedelrahman, Sayed, Mohamed AL, Alberkamy, Abdelrahman, Aldahma, Mohamed, Ali, Ahmed, Ali, Mostafa, Bakr, Mohamed Amin, Anter, Alaa, Asal, Doaa, Ashoush, Fouad, Ashraf, Olfat, Ashraf, Abdel Rahman, Atta, Rewan, Badr, Salma, Bahaaeldin, Mohamed, Bastawesy, Mostafa, Darwish, Sara, El Kharashy, Rasha, Elassar, Ziad, Elbadawy, Seifeldin, Elkhity, Dina, Elsaka, Alromisaa, Elsayed, Manal, Hewalla, Mostafa Elsayed Elsayed, Elshafey, Mohamed, Eshac, Youssof, Eshac, Fares, Essameldin, Amr, Ewedah, Moataz, Ezz, Yara, Farag, Mohamed, Gadelkarim, Inas, Gadelrab, Ziyad, Gamal, Dina, Ghaly, Mira, Girgis, Nathalie, Gouda, Omar, El Goweini, Nancy H., Hafez, Nour, Hafez, Youssef, Abdin, Abdelkader Hamed, Hanno, Rodina, Hassanin, Aliaa, Hassanin, Mohamed, Hemead, Hanan M., Hemida, Abdelrahman, Hosain, Maher, Hossam, Ahmed, Aly, Hamza Hussein Aly Salama, Ibrahim, Mohamed, Ibrahim, Abdelrahman, Ibrahim, Nourhan, Hamouda, Noha Mohamed Salah Ibrahim Moussa, Iskander, Monica, Khalifa, Islam, Kotb, Mostafa, Mahmoud, Nada, Shabana, Alaa Mahmoud Abo, Mamdouh, Nora, Metwalli, Maram, Metwally, Khaled, Moghazy, Mahmoud, Mohamed, Moustafa, Mourad, Mohamed, Moustafa, Esraa, Mubarek, Kamilia, Nader, Nour Eldin, Nasser, Ahmed, Omar, Samaa, Qatora, Mostafa Shehata, Ragab, Mohamed, Ragal, Marawan, Ramadan, Dina, Ramadan, Rana, Ramadan, Sara, Romany, John, Sabry, Ahmed, Said, Yasmeen, Salamah, Sara, Saleh, Ahmed Mostafa, Elkaffas, Mona Saleh Mesbah Mohamed, Salem, Alaa, Salim, Hashem, Samih, Ahmed, Abdelaal, Ahmed Samir, Shaheen, Ahmed, Mohammed, Yassmeen Sharafeldin, Shehata, Abdelrahman, Shemeis, Mohamed, Shenit, Karim, Sheta, Mennatallah, Soffar, Asmaa, Tanas, Yousef, Tarek, Ahmed, Yehia, Nermin, Eid, Omar Khaled Mohamed, Abdulfattah, Ammar Yasser, Elsaghir, Ahmed, Elganainy, Mohamed Fouad, Elsayed, Omar Ibrahim, Elmandouh, Omar, Hamam, Omar, Shehata, Mostafa Ahmed, Abdelaziz, Areej A., Abbas, Ahmed M., El‐ghani, Wael Abd, Abd Elazeem, Hossam Aldein S., Elsayed, Mustafa Abd, Abd‐elkariem, Ahmed Yassien, Abdalla, Shimaa, Abdel‐aleem, Mahmoud, Abdelazeem, Khaled, Abdelfattah, Mahmoud, Abdelhafez, Mohammed, Abdelkarem, Mohamed M., Abdelraouf, Ali, Abdullaha, Lamess, Abubeih, Hossam, Ahmed, Moaiad Eldin, Ahmed, Nagm Eldin Abu Elnga, Ahmed, Ahmed, Saad, Sarah Ahmed, Alaa, Sherif, Alhussaini, Ali, Ali, Abdelrahman Ahmed Abdelrahman, Ali, Ibrahim, Ali, Wagdi, Mohamed, Mohamed Ali, Ashraf, Mohamed, Bassiouni, Muhammad, El‐adawy, Mohamed G., El‐sharkawi, Mohammad, Elkhayat, Hussein, Elmaghraby, Khaled, Elsdfy, Shady, Elsharkawy, Mohamed, Eltayeb, Almoutaz, Mohamed, Mohamed Esmat, Essam, Esraa, Fahd, Mahmoud, Farouk, Osama, Gadelkareem, Rabea, Ghoneim, Ahmed, Takrouney, Mohammed Hamada, Hamdan, Ahmed, Hamed, Abd El‐Rahman, Hasan, Ahmad, Hassanin, Mohamed Abdelghafor, Hawal, Islam, Henes, Kerollos, Herdan, Mohamed Omar, Hetta, Helal F., Ibrahem, Omar, Ibrahim, Mostafa, Ibrahim, Islam H., Kamel, Mahmoud, Khallaf, Mohamed, Elghazaly, Shrouk M., Mahfouz, Abobakr, Mahmoud, Osman, Mahran, Wesam, Mahrous, Doha, Marsis, Abadeer, Mohamed, Ayman, Hussein, Aliae Mohamed, Sayed, Amr Mohamed, Mohammed, Mahmoud M, Mokhtar, Ahmed, Monib, Fatma A., Nageeb, Ahmed, Nageh, Mariam Albatoul, Nageh, Mohammed, Omar, Nehal Gamal, Ragab, Abdelrahman, Ramadan, Abdelrahman, Temerik, Abdallah Rashad, Sabry, Aya, Safwat, Hadeer, Salah, Omar, Mahmoud, Ahmed Elhussiny Salah, Saleh, Ahmed, Sallam, Mahmoud, Samir, Ahmed, Sayad, Reem, Sayed, Esraa, Sedik, Ahmed S., Shahine, Mohammed, Soliman, Antonios, Soliman, Wael, Taher, Mohamed Gamal, Wanees, Randa, Yousof, Ebrahim Ahmed, Youssef, Ahmed, Elabedeen, Omar Zein, Hassan, Ahmed Emad Sayed, Fattah, Shrouk Abdel, Abostate, Ahmed, Ali, Samar, Salama, Saad Ali Saad, Allam, Mohamed, Alsadek, Ahmed, Arafa, Ebrahim, Barakat, Ahmed, El Sherpiny, Mohammed, Elbehairy, Gehad, Eleisawy, Mahmoud, Elgendy, Abdelrahman, Elhawary, Rewan, Eltregy, Sherif, Hamdy, Mahmoud, Hassan, Gehad, Khalifa, Aya, Mahmoud, Ahmed, Altukhy, Ahmed Mohamed, Noah, Kareem, Noureldin, Yasser, Nowar, Mostafa, Saad, Moustafa, Elsaeidy, Ahmed Saad, Elsaeidy, Khaled Saad, Sabry, Hesham, Sameh, Mostafa, Said‐elnaby, Ahmed Tarek, Zahed, Mohamed, Zahran, Mohamed, Zaid, Abdelrahman, Zoghary, Ahmed Zaki, Atef, Mohamed, Mohamed, Ahmed, Youssef, Mohamed, Abdelhamid, Mahmoud Hossameldin Saad, Alazab, Emad, Awad, Ahmed K., Darwesh, Amr, El Fiky, Lobna, Elgarhy, Ibrahim, Nassef, Mohamed Adel, Shaban, Mahmoud, Shalaby, Mahmoud Mohamed Mohamed, Wahba, Abdelrahman, Fouad, Omar Youssif Omar, Elsadek, Menan, Gad, Dalia, Abdelsamed, Ahmed, Bayomy, Abdulhakeem, Elsalhy, Mohamed, Fahim, Ahmed, Seleim, Ahmed, Afifi, Eman, Gamal, Fatma Alzahraa, Gamal, Mennatullah, Eldesouky, Omnia, Eldwini, Mohamed Hatem Elmetwalli Eldwini, Fahmy, Mostafa Medhat Fahmy, Hussein, Ahmed, Ouf, Abdallah, Sami, Omar, Shaat, Salem, Bahi, Abdullah Wael Mostafa Khalil, Atea, Abdurhman, Gamal, Ibrahim, El Kassas, Mohamed, Omar, Wael, Tawheed, Ahmed, Al‐oribi, Saeid, Aly, Nuran Khaled, Elfiky, Mahmoud, Elmaghraby, Alaa Eldine, Elrahmany, Abdulrahman, Elsherbeeny, Motaz, Helmy, Youssef, Nabil, Ahmed, Farahat, Ahmed Samir, Soliman, Mostafa, Wassef, Amr, Abdelrahman, Abdelrahman, Elsaban, Seif, Ghaly, Galal, Hamdy, Rana, Mondy, Hamada, Abdallah, Lubna, Darwish, Abdelrhman KZ, Rabea, Mohamed, Azab, Mohammed A, Abbas, Alzhraa Salah, El‐deeb, Marwa, Fawzy, Mohamed, Ibraheem, Maher, Bakry, Abdelrahman, Elnems, Sarah, Elsheikh, Randa, Gbreel, Mohamed Ibrahim, Hafez, Mahmoud, Jammal, Mohamed, Hamam, Khaled M, Makram, Abdelrahman M, Makram, Omar Mohamed, Rabie, Salma, Askalany, Sherine Yousery, Abushanab, Mokhtar Mohamed Ibrahim, Eid, Abdulrahman, El Ghalid, Mohammed Refaat Ibrahiem Amin, Abdelaty, Ahmed Adel, Fayad, Elsayed A., Radwan, Asmaa, Sallam, Moataz, Shokry, Ahmad, Farouk, Ahmed Mohamed, Elfallal, Ahmed, Elfeki, Hossam, Elsaeed, Mohamed, Elsaid, Mahmoud, Makroum, Amany, Elsaid, Dina Mohamed, Mostafa, Mohamed, Omar, Mohamed W, Rezk, Mohamed, Sakr, Ahmed, Sanad, Aly, Shalaby, Mostafa, Shawqy, Mohammed, Shetiwy, Mohamed, Shoma, Ashraf, Tawakl, Noura, Yunes, Asmaa, Abouzid, Amr, Atallah, Khalid, Elmorsi, Rami, Elsherbini, Ahmed, Gaballa, Khaled, Hamdy, Omar, Hamdy, Mohamed, Metwally, Islam Hany, Refky, Basel, Shetiwy, Mosab, Zuhdy, Mohammed, Zahran, Mohammed A, Abdellah, Fatima, Abdelmawla, Ahmed, Abdrabou, Ahmed, Abubakr, Asmaa, Al Gohary, Rawda, Al‐shazly, Mohammed Hamdy, Ali, Mohamed, Allam, Abdallah R, Aposaeeda, Aya, Asfour, Mohammed, Ayman, Ammar, Omran, Abdelrahman Azzam, Daghash, Ibrahim Tawfiq, Ebada, Mahmoud Ahmed, Eid, Taher, El Kelany, Ahmed, El Shemy, Esraa, El‐hag‐aly, Mohammed, Elgamal, Omar, Elghoury, Mahmoud, Elkased, Ahmed Farag, Ellakwa, Takwa Hamed, Ellakwa, Hamed, Elmeanawy, Amr, Elnoamany, Salma, Elsabagh, Alaa, Elsawey, Abdelrahman, Elshabrawy, Enas, Elshakhs, Seliman, Elsoudy, Naira, Ezzat, Esraa, Fawzy, Ahmed, Gamal, Abrar, Gameel, Ahmed, Gharbia, Khaled, Ghonaim, Mohamed, Ghonaim, Alaa, Hafez, Ahmed, Hafez, Abdelrahman, Ismail, Zainab, Khaled, Mohamed, Meselhy, Mohammed, Mikhail, Pola, Mohamed, Mervat, Mougahed, Mohamed, Mustafa, Abdulla, Nada, Ahmed, Omran, Janna, Ebiad, Mohamed S., Saleh, Ibrahiem, Salem, Nourhan, Salem, Osama, Selim, Salma, Shalaby, Ghada, Sherif, Hoda, Soltan, Hatem, Wahbah, Mahmoud, Abdelbary, Eman Zakaria, Zayan, Ahmad Helmy, Afify, Abdelrahman, Hadiya, Hossam Ali, Elshref, Mohamed Jamal, Ahmed, Mostafa Mohamed, Nasser, Nourhan, Abdeldayem, Hesham, Salama, Ibrahim Abdelkader, Ammar, Khaled, Ayoub, Islam, Aziz, Amr, Badawy, Mohammad Taha, Balabel, Mohamed, Fayed, Yahya, Gad, Emad Hamdy, Gomaha, Maher, Hammad, Essam, Hegazy, Osama, Hegazy, Elsayed, Ibrahim, Tarek, Kallaf, Mostafa, Macshut, Mahmoud, Magdy, Ammar, Oteem, Ahmed, Sallam, Ahmed, Samaan, Samy, Sharshar, Mohamed, Shoreem, Hany, Soliman, Elsayed, Soliman, Hossam Eldeen, Yassein, Taha, Zakaria, Hazem, Eldaly, Abdullah, Mashaly, Sarah, Abd‐elsalam, Sherief, Abdel‐elsalam, Wafaa, Shaalah, Ahmed Abdullah, Elbahnasawy, Mohamed, Elhalaby, Ismael, Hamada, Mohamed, Soliman, Sarah Hamdy, Hawila, Ahmed, Morsy, Mohamed Sherif, Naieem, Mohmed, Nasreddin, Mohammed, Salman, Samar, Sarsik, Sameh, Shabana, Ahmed, Tolba, Engy, Zagho, Mohamed, Kams, Liisa, Rätsep, Tõnu, Riips, Karolin, Abdurehman, Oumer, Admasu, Azarias, Berhea, Ataklitie, Eado, Yegeremu, Hailu, Nebiyou, Kidane, Meklit, Mohammed, Abdurezak, Mohammed, Khalid, Tibelt, Admasu, Woldemariam, Mersha Abebe, Yonael, Lydya, Alemu, Megersa, Aklilu, Abenezer Tirsit, Asele, Frehun, Assefa, Solomon, Azmach, Dawit, Bekele, Philimon, Mamo, Mickyas, Maru, Nahom, Mekuria, Haile, Menkir, Abel, Mikru, Filagot, Siraw, Eyerusalem, Suga, Hilkiah, Sumoro, Natnael, Teka, Aklilu, Thomas, Efeson, Woldemariam, Dereje, Wubishet, Estifanos, Abebe, Engida, Abebe, Kirubel, Asfaw, Fitsum, Bergene, Eyerusalem, Eshete, Mahder, Gebrehiwot, Fitsum Gebreegziabher, Gedefaw, Yetsedaw, Mengesha, Mulualem Wondafrash, Mengiste, Netsanet, Menjeta, Abeje, Muleta, Mahteme Bekele, Sefera, Sena, Tedla, Yonatan, Teklu, Daniel, Teshome, Henok, Tirfe, Leake, Tsegabrhan, Sahle, Tsehaye, Milkias, Worku, Bereket, Molla, Million, Supha, Melka, Taye, Tewodros, Abebe, Nebyou, Alemu, Berhanu, Chanie, Abera, Degefu, Hailegebriel, Desalegn, Dawit, Gebre, Hiwot, Hussen, Husnia, Kassa, Dawit, Laeke, Tsegazeab, Mammo, Tihitena Negussie, Negash, Samuel, Sahlu, Abat, Tiruneh, Abraham Genetu, Wolde, Amanuel, Woldeselassie, Hanna Getachew, Ahmed, Mnewer Y., Zewdneh, Betelhem, Fentaw, Jibril, Salia, Shemsedin, Tabore, Ketema, Gurara, Addisalem, Abreha, Tassew, Abrha, Teklebirhan, Beyene, Gaym, Hailu, Niguse, Weldu, Mulu Atsbaha, Abdissa, Desalegn, Tesfaw, Mequannet, Wolle, Melatework, Asmamaw, Dawit, Assefa, Biniam Zemedu, Bedane, Dereje, Bekele, Ephrem, Getie, Aderaw, Melkamu, Solomon, Mengesha, Workineh, Shumye, Getachew, Tagele, Gashaye, Tesfa, Abrham Amare, Workneh, Wubshet, Genetu, Sileshi, Mebratu, Eneyew, Chanyalew, Lidya, Deresse, Tilahun, Girma, Adissu, Seid, Marta, Shimelash, Dagim, Shitaw, Abrham, Ayalew, Tewabe, Diress, Tesfaye, Kassahun, Berhanu, Kassaye, Bersabeh, Mulugeta, Esubalew, Tesfaw, Getasew, Yimenu, Beminet, Benecha, Semir, Aman, Mudesir, Ibrahim, Adem, Mekete, Alem, Tesemma, Abdi, Mohammed, Adnan Abdulkadir, Abdullahi, Yasir Younis, Adem, Ephrem, Ahmedin, Mahlet, Assefa, Yared, Ayde, Fitsum, Berhe, Alazar, Gebremeskel, Zersenay, Siyoum, Eneyew Getachew, Teresa, Sintayehu, Wude, Zinaye, Yemer, Fasika, Yohannes, Dagnachew, Zeleke, Ewunetu, Zerihun, Gulilat, Degefe, Derje Worku, Derilo, Hankore Tamirat, Eliyas, Nebiyu, Bayissa, Firew, Deressa, Yadani, Gemechu, Lidya, Gurmu, Tegenu, Kasaye, Ashenafi, Melese, Lemi, Muleta, Lemesa, Mulugeta, Gersam, Taye, Seifu, Teshome, Abraham, Tesso, Birhanu, Gebrekirstos, Gebreagziabher, Haile, Mhreteab, Kassa, Haftamu, Saddik, Mohammed, Mengist, Alemneh, Heikkinen, Juuso, Helminen, Olli, Huhta, Heikki, Kotkavaara, Tommi, Mosorin, Matti‐aleksi, Pitkänen, Joel, Qian, Cheng, Sinikumpu, Jaakko, Sova, Henri, Tastula, Mikko, Virta, Ville P, Bettoni, Jérémie, Dakpé, Stéphanie, Devauchelle, Bernard, Lavagen, Nolwenn, Bastard, François, Bin, Kim, Breheret, Renaud, Fouquet, Olivier, Gueutier, Alexandre, Henric, Nicolas, Kahn, Alexis, Kün‐darbois, Jean‐daniel, Moukoko, Didier, Pineau, Anna, Podevin, Guillaume, Schmitt, Françoise, Alshawared, Fadi, Beyrne, Carlos Daniel, Lugans, Laurene, Marie‐macron, Lysa, Doussot, Alexandre, Ahmed, Omar, Alnajjar, Louy, Mis, Tommaso Cipolat, Fliss, Souha, Giocanti‐auregan, Audrey, Gregory, Thomas, Guiraudet, Patrice, Le Fouler, Adrien, Martinod, Emmanuel, Onorati, Ilaria, Peretti, Marine, Quilichini, Julien, Radu, Dana, Trésallet, Tresallet, Andro, Christophe, Maffert, Alexis, Chapman, Tracy, Halden, Maxime, Fayon, Julie, Mattevi, Catherine, Marion, Herjean, Bendjemar, Lynda, Lionel, Charre, Mikhael, Elie, Macías, Rosa Montero, Villefranque, Vincent, Volpin, Enrico, Trilling, Bertrand, Boleslawski, Emmanuel, Constance, Houlzé‐laroye, Drubay, Vincent, El Amrani, Mehdi, Eveno, Clarisse, Lecolle, Katia, Martin, Louis, Noiret, Barbara, Piessen, Guillaume, Truant, Stephanie, Zerbib, Philippe, Aubry, Estelle, Denimal, Franck, Lamblin, Antoine, Barrat, Benjamin, Caire, François, Christou, Niki, Fourcade, Laurent, Laloze, Jerome, Bouv‐hez, Margaux Mekann, Salle, Henri, Taibi, Abdelkader, Tricard, Jeremy, Usseglio, Julie, Chopinet, Sophie, Gregoire, Emilie, Delpont, Marion, Blanchard, Claire, Crenn, Vincent, Vergie, Stéphane, Denis, Waast, Fragnaud, Henri, Regenet, Nicolas, Rigaud, Jerome, Varenne, Yoann, Anract, Philippe, Barat, Maxime, Biau, David, Dautry, Raphaël, Dohan, Anthony, Idier, Louis, Lang, Elena, Thouny, Camille, Tzedakis, Stylianos, Audenet, François, Cazelles, Antoine, Chamouni, Alexandre, Karoui, Mehdi, Mejean, Arnaud, Clermidi, Pauline, Langlais, Tristan, Leonelli, Lorenzo, Maisonneuve, Emeline, Nicolas, Beaud, Perrot, Ophelie, Prost, Doriane, Thomin, Anne, Thouement, Thouement, Athiel, Yoann, Berry, Richard, Boddaert, Guillaume, Bonnet, Stéphane, Cathala, Nathalie, Conso, Christel, Denet, Christine, Laforest, Anaïs, Levy‐zauberman, Yael, Macek, Petr, Mombet, Annick, Ollat, Didier, Scamporlino, Adriana, Zadegan, Frederic, Amine, Chamakhi Ahmed, Baratte, Baratte, Chartier‐kastler, Emmanuel, Chereau, Nathalie, Colas, Pierre‐antoine, Duquesne, Igor, Genser, Laurent, Petit, Gaëlle Godiris, Goumard, Claire, Hasani, Ariola, Lim, Chetana, Martellotto, Sophie, Melot, Charlotte, Menegaux, Fabrice, Pinar, Ugo, Pocard, Marc, Roupret, Morgan, Scatton, Olivier, Seisen, Thomas, Séverine, Noullet, Turco, Célia, Chouillard, Elie, Beganton, Paul, Frasca, Denis, Kerforne, Thomas, Corbiere, Lisa, Gasmi, Anis, Ghemame, Marwane, Guérin, Sonia, Khene, Zine‐eddine, Livin, Marie, Mahmoud, Fedy, Maillot, Betty, Merdrignac, Aude, Mouriaux, Frederic, Robin, Fabien, Sulpice, Laurent, Vazeux, Charles, Bertheuil, Nicolas, Bonneau, Soline, Cazemajou, Clément Thierry, Cousin, Ianis, Defert, Coralie, Fustec, Elisa, Juricic, Melodie, Lavoue, Vincent, Mevel, Gwenaël, Timoh, Krystel Nyangoh, Renault, Annaëlle, Violas, Philippe, Schwarz, Lilian, Tuech, Jean Jacques, Morichau‐beauchant, Tristan, Sauvat, Frederique, Haddad, Elie, Vermersch, Sophie, Patrizi, Andrea, Roux, Alexia, Aimé, Adeline, Malgras, Brice, Cherkaoui, Zineb, D’Urso, Antonio, Felli, Emanuele, Gonzalez, Cristians Alejandro, Ignat, Mihaela, Mutter, Didier, Pessaux, Patrick, Vix, Michel, Gornes, Hugo, Vergriete, Kélig, Berthoumieu, Pierre, Genre, Ludivine, Le Gall, Hélène, Pierre, Trocard, Chalhoub, Marc, Del, Mathilde, Martinez, Alejandra, Fuchs‐buder, Thomas, Vancon, Antoine, Faya, Camara Abraham, Asaph, Elvam, Baruwa, Elisee, Hofman, Gwen, Machemedze, Solomon, Idiata, Michael Mayombo, Muhemi, Roger, Ndizeye, Olivier, Nkunzimana, Elysé, O’Connor, Jennifer, O’Connor, Zachary, Tchoba, Simplice, Boumas, Natacha, Devidze, Grigol, Pisarevi, Givi, Baumgarten, Sabine, Grüßer, Linda, Hölzle, Frank, Kowark, Pascal, Kowark, Ana, Rossaint, Rolf, Schäfer, Benedikt, Wallqvist, Julia, Winnand, Philipp, Ziemann, Sebastian, Anthuber, Matthias, Broecheler, Tobias, Edlinger, Florian, Goßlau, Yvonne, Hyhlik‐duerr, Alexander, Maksymiw, Florian, Shiban, Ehab, Sommer, Florian, Sommer, Björn, Zerwes, Sebastian, Beyer, Katharina, Lauscher, Johannes Christian, Lee, Lucas D., Loch, Florian N, Schineis, Christian, Aghalarov, Ilgar, Belyaev, Orlin, Braumann, Chris, Enste, Annika, Fahlbusch, Tim, Herzog, Torsten, Horn, Julian, Jedanowski, Julia, Knipschild, Julia, Luu, Andreas Minh, Mohan, Prem Vignesh, Siemen, Leonie, Slobodkin, Illya, Strotmann, Johanna Josefine, Uhl, Waldemar, Wolf, Katerina, Coburn, Mark, Egger, Eva, Eichhorn, Klaus, Enderes, Jana, Far, Frederick, Franzen, Alina, Güresir, Erdem, Hadjiathanasiou, Alexis, Kalff, Jörg C., Kohistani, Zaki, Manekeller, Steffen, Mustea, Alexander, Probst, Chris, Randau, Thomas, Recker, Florian, Schuss, Patrick, Straßberger‐nerschbach, Nadine, Strieth, Sebastian, Treede, Hendrik, Beekum, Cornelius J., Vatter, Hartmut, Velten, Markus, Vilz, Tim O., Wirtz, Dieter, Wittmann, Maria, Behr, Michael, Bulian, Dirk Rolf, Marche, Benedikt, Moczko, Tobias, Otchwemah, Robin, Schulz, Sissy‐amelie, Thomaidis, Panagiotis, Bruns, Christiane, Cursiefen, Claus, Domröse, Christian, Fuchs, Hans, Heindl, Ludwig Maximilian, Mallmann, Michael R., Mallmann, Christoph, Ratiu, Dominik Alexander, Canzler, Ulrich, Distler, Marius, Korn, Sandra, Meisel, Cornelia, Meusel, Marcus, Petzold, Andrea, Praetorius, Christian, Renesse, Janusz, Weitz, Juergen, Wimberger, Pauline, Alkhanji, Nour, Fung, Stephen, Jaber, Kefah, Knoefel, Wolfram Trudo, Vay, Christian, Clonda, Octavian, Cottin, Tatiana, Juodiene, Evelina, Juodis, Domantas, Petrovic, Biljana, Solodarenko, Oleksandra, Binder, Johannes, Grützmann, Robert, Hackner, Danilo, Junker, Stefanie, Arsalan, Mani, Banek, Severine, Chun, Felix, Faqar‐uz‐zaman, Sara Fatima, Keese, Daniel, Kluth, Luis, Rolle, Udo, Van Linden, Arnaud, Walther, Thomas, Bayer, Jörg, Beck, Jürgen, Fung, Christian, Kraus, Luisa Mona, Leiber, Christian, Neidert, Nicolas, Sandkamp, Richard, Schnell, Oliver, Schulte, Antonia, Strähle, Jakob, Jarmusch, Stefanie, Novotny, Helmut Franz Georg, Becker, Johannes, Fulghum, Christian, Gonschor, Bernhard, Herbolzheimer, Marit, Nicolaiciuc, Sina, Trulson, Alexander, Vogelsang, Holger, Zimmermann, Benno, Akbari, Amir Ali, Boening, Andreas, Edinger, Fabian, Hecker, Matthias, Knitschke, Michael, Koch, Christian, Reichert, Martin, Schmidt, Götz, Schneck, Emmanuel, Uhl, Eberhard, Nóbrega, Silvia Flachs, Kauffmann, Philipp, Miller, Clemens, Nemeth, Marcus, Sievers, Denise, Kisser, Ulrich, Kleeff, Jorg, Klose, Johannes, Lorenz, Kerstin, Papendick, Nancy, Plontke, Stefan, Seiwerth, Ingmar, Steer, Susanne, Thomssen, Christoph, Ukkat, Jörg, Dumpies, Christian W., Fischer, Isabel, Gessner, Michael, Hanke, John, Klauke, Friederike, Leuschner, Sebastian, Mendel, Thomas, Müller, Katharina, Schmidt, Birte, Schreiter, Valentin, Stosberg, Peter, Vinz, Franziska, Herbig, Beate, Sander, Johannes, Schulte, Thilo Maria, Betz, Christian Stephan, Bewarder, Julian, Bier, Johannes, Böttcher, Arne, Burg, Simon, Busch, Chia‐jung, Bußmann, Lara, Gosau, Martin, Heuer, Annika, Izbicki, Jakob, Klatte, Till Orla, König, Daniela, Köpke, Leon‐gordian, Moeckelmann, Nikolaus, Praetorius, Mark, Priemel, Matthias, Stadlhofer, Rupert, Stangenberg, Martin, Uzunoglu, Faik G., Wittig, Lukas, Zech, Henrike, Zeller, Nina, Roux, Frederic, Spaeth, Tsiona, Fricker, Roland, Müller, Thomas, Schröder, Lars, Alasmari, Mohammed, Boeker, Clara, Hakami, Ibrahim Abdullah, Mall, Julian W, Kyritsis, Ioannis, Graeb, Christian, Huber‐strößner, Kristin, Branzan, Daniela, Doss, Markus, Gockel, Ines, Jödicke, Carolin, Osterhoff, Georg, Pempe, Christina, Sucher, Robert, Adler, Tina, Kelly, Kathrin, Merkle, Janica, Siebert, Julia, Hirche, Christoph, Kneser, Ulrich, Tapking, Christian, Agrawal, Rachit, Qureischie, Homeira, Croner, Roland, Koslowski, Lisa, Krause, Hardy, Meyer, Frank, Turial, Salmai, Al‐nawas, Bilal, Battista, Marco Johannes, Goedeke, Jan, Hasenburg, Annette, Heider, Julia, Mueller, Lena Katharina, Zeller, Simon, Jentschura, Sina Louisa Patrizia, Kowalewski, Karl‐friedrich, Kriegmair, Maximilian, Männle, David, Reissfelder, Christoph, Rotter, Nicole, Scherl, Claudia, Seyfried, Steffen, Kirschniak, Andreas, Rolinger, Jens, Wilhelm, Peter, Bader, Franz G., Ottl, Stephanie, Behr, Alexandra Viktoria, Diamantis, Alexandros, Fichter, Andreas, Grill, Florian, Heck, Matthias, Jira, Daniel, Kallmayer, Michael, Koll, Florestan, Luhne, Stefan, Meyer, Bernhard, Patachia, Robert, Pergolini, Ilaria, Safi, Seyer, Schäffer, Christoph, Schirren, Moritz, Wegmann, Helmut, Wirth, Markus, Zhu, Zhaojun, Aghamaliyev, Ughur, Almaghrabi, Mahmoud, Böcker, Wolfgang, Bruder, Jan, Frank, Konstantin, Herterich, Viktoria, Huber, Verena, Ilmer, Matthias, Kammerlander, Christian, Neuerburg, Carl, Ehrlich‐treuenstätt, Viktor H., Werner, Jens, Börner, Nikolaus, Fegg, Florian, Hartmann, Daniela, Ladurner, Roland, Liokatis, Paris, Patzer, Kathrin, Schlager, Justin Gabriel, Smolka, Wenko, Zimmermann, Petra, Hatz, Rudolf, Steinhart, Diana, Glowalla, Claudio, Schneidmueller, Dorien, Henkel, Karl Wilhelm, Steiner, Martin, Hölz, Katharina, Knorr, Christian, Kuehlmann, Britta, Oikonomou, Kyriakos, Prantl, Lukas, Flurschütz, Roland, Honarpisheh, Human, Kröger, Marie, Lepiorz, Dominic, Luths, Charlotte, Niemeier, Andreas, Sras, Yara, Strate, Tim, Winter, Thore, Freiman, Thomas, Gessler, Florian, Won, Sae‐yeon, Widyaningsih, Rizky, Hoffmann, Sebastian, Schäfer, Ruth Christine, Thiel, Johannes Tobias, Bertolani, Elisa, Steidle, Christoph, Überrück, Lisa, Yurttas, Can, Ziegler, Patrick, Zimmermann, Alexander, Bolenz, Christian, Dayan, Davut, Greve, Jens, Hoffmann, Thomas K., Janni, Wolfgang, Löbig, Niklas, Schochter, Fabienne, Vahl, Julius Malte, Wezel, Felix, Greif, Veronika, Schmidbauer, Stefan, Marsch, Imke, Schneider, Rolf, Boenicke, Lars, Degener, Stephan, Dreger, Nici Markus, Horstmeier, Franz Christian, Kruschwitz, Jakob, Rombach, Adrian, Schmidt, Nele, Seiberth, Rose, Singh, Jaswinder, Smit, Marieke, Rundstedt, Friedrich‐carl, Zirngibl, Hubert, Diessner, Joachim, Friedrich, Sabine, Germer, Christoph‐thomas, Helmer, Philipp, Herrmann, Johannes, Kranke, Peter, Kübler, Hubert, Lock, Johan, Lotz, Christopher, Meffert, Rainer, Meybohm, Patrick, Müller, Sophie, Notz, Quirin, Popp, Maria, Schlegel, Nicolas, Schlesinger, Tobias, Schmid, Benedikt, Sitter, Magdalena, Steinisch, Andreas, Treutlein, Agnes, Berg, Anne, Wurmb, Thomas Erik, Agyeman‐duah, Nana Kwaku, Appiah, Enoch, Armah, Ralph, Asare, Christopher, Awere‐kyere, Lawrence, Daary, Dennis, Gakpetor, Delali, Allah, Stephen Minlah, Obbeng, Ambe, Osei‐poku, Dorcas, Puozaa, Diana, Tackie, Enoch, Adu‐aryee, Nii Armah, Agboadoh, Nelson, Asare, Offei, Bowan, Antoinette Bediako, Brown, George Darko, Clegg‐lamptey, Joe‐nat, Dedey, Florence, Dery, Cedric, Fenu, Benjamin Sena, Harrison, Marian Abedua, Kumassah, Philemon, Kuuzie, Ekins, Nsaful, Josephine, Olayiwola, David Olatayo, Smith, Cecilia, Banka, Charles, Hussey, Romeo, Azize, Diallo Abdoul, Aniakwo, Luke Adagrah, Adofo‐asamoah, Yvonne, Agbeno, Evans Kofi, Agyapong, Meshach Manu, Agyen, Thomas, Mensah, Kwasi Agyen, Alhassan, Baba Alhaji Bin, Amoako‐boateng, Mabel, Appiah‐thompson, Peter, Gyimah, Nita Asamoa‐Manu, Asante‐bremang, Moses, Asante‐asamani, Alvin, Atawurah, Henry, Appiah, Anthony Baffour, Baidoo, Richard Ogirma, Baidoo, Ebikela Ivie, Boakye, Benedict, Boateng, Abigail, Dadoe, Dora, Dayie, Makafui Seth Caleb‐Joshua Kwasi, Debrah, Samuel, Doku, Kingsley, Enti, Enti, Ken‐amoah, Sebastian, Koggoh, Patience, Kpangkpari, Richard, Maison, Patrick, Mensah, Samuel, Mensah, Philip, Mensah, Teresa Aba, Morna, Martin Tangnaa, Nimako‐mensah, Jilac, Nkrumah, John, Nortey, Michael, Ofori, Emmaunel Owusu, Opandoh, Isabella Naa Morkor, Osei‐tutu, Ethel, Adae, Jefferson Owusu, Quansah, Kofi, Quartson, Elizabeth, Rahman, Ganiyu Adebisi, Walawah, David, Yigah, Makafui, Yussif, Safia, Jiagge, Nuna, Nachelleh, Emmanuel, Acquaye, Jane, Agbedinu, Kwabena, Agyei, Fareeda, Agyemang‐prempeh, Akosua, Amo‐antwi, Kwabena, Amoah, Michael, Amoah, George, Amoako, Yaw A, Aning, Daniel Gyawu, Ankobea‐kokroe, Frank, Mintah, Dominic Annor, Anyitey‐kokor, David, Appiah‐kubi, Adu, Arthur, Joshua, Ativor, Vincent, Barnor, Isaac, Braimah, Yasmine, Darko‐asante, Regina, Davor, Anthony, Issahalq, Mohammed Duah, Dzogbefia, Mawutor, Emile, Tano, Fiifi‐yankson, Papa, Gaveh, Valerie, Gudugbe, Senyo, Gyabaah, Solomon, Gyamfi, Frank Enoch, Gyedu, Adam, Gyimah, Derrick, Hammond, Bernard, Jonathan, Boakye‐yiadom, Joseph, Yorke, Konney, Thomas Okpoti, Konney, Anna, Kusi, Kwasi, Kyei, Ishmael, Lovi, Agbenya, Naabo, Nuhu, Nimako, Boateng, Nyadu, Beauty, Nyarko, Obed Ofori, Ofosu‐barko, Ben Blay, Oppong, Philip Peprah, Osabutey, Anita, Poku, Martha, Sagoe, Robert, Yifieyeh, Abiboye, Ansong, George, Abass, Adam, Abdul‐mumin, Alhassan, Adjeso, Theophilus, Alatiiga, John Abanga, Amadu, Munira, Annan, Nathaniel, Leal, German Azahares, Bukari, Mohammed, Buunaaim, Alexis, Cheyuo, Ernest, Salifu, Latif Daboo, Damah, Michael, Dery, Malcolm, Dzantor, Edem Kojo, Garcia, Odoniel Guerra, Baba, Yabasin Iddrisu, Issaka, Adamu, Muntaka, Abdul‐Jalilu Mohammed, Murphy, James, Agyeman, Yaa Nyarko, Amankwaa, Wisdom Opoku, Osman, Imoro, Pie, Samuel, Seidu, Anwar Sadat, Sheriff, Mohammed, Charadan, Ana Maria Simono, Titigah, Abraham, Yahaya, Mundashiru, Yakubu, Musah, Yenli, Edwin Mwintiereh Ta‐ang, Grypiotis, Ioannis, Kiriakopoulos, Nikolaos, Koliopoulos, Georgios, Kyvelos, Vasilis, Micha, Georgia, Papadopoulou, Triada, Balalis, Dimitrios, Fradelos, Evangelos, Korkolis, Dimitrios, Alexakis, Nicholas, Angelou, Kyveli, Haidopoulos, Dimitrios, Prodromidou, Anastasia, Rodolakis, Alexandros, Thomakos, Nikolaos, Psychogios, Dimitris, Antonakis, Pantelis, Bramis, Konstantinos, Chardalias, Leonidas, Contis, Ioannis, Dafnios, Nikos, Dellaportas, Dionysios, Dimitra, Papalouka, Fragkoulidis, Georgios, Gkiokas, Georgios, Gklavas, Antonios, Hadjizacharias, Theodoros, Karageorgou, Dimitra, Konstadoulakis, Manousos, Kontopoulou, Christina, Massaras, Dimitrios, Memos, Nikolaos, Papaconstantinou, Ioannis, Politis, Dimitrios, Polydorou, Andreas, Stamatis, Konstantinos, Theodosopoulos, Theodosios, Vezakis, Antonios, Avgerinos, Konstantinos, Katunin, Jevgeni, Kechagias, Aristotelis, Kelgiorgi, Dionysia, Kritikos, Neoklis, Pengermä, Pasi, Bisdas, Theodosios, Ioannidis, Argyrios, Konstantinidis, Michael, Konstantinidou, Sofia, Patelis, Nikolaos, Antonopoulou, Maria Ioanna, Deskou, Eirini, Kalles, Vasileios, Manatakis, Dimitrios K., Stamos, Nikolaos, Tasis, Nikolaos, Arkadopoulos, Nikolaos, Danias, Nikolaos, Economopoulou, Panagiota, Frountzas, Maximos, Kokoropoulos, Panagiotis, Michalopoulos, Nikolaos, Selmani, Jonida, Sidiropoulos, Theodoros, Vassiliu, Panteleimon, Paraskevas, Kosmas I., Bartziotas, Dimitrios, Bouchagier, Konstantinos, Galanis, Ilias, Kalamatianos, Theodosis, Kapiris, Stylianos, Kolinioti, Angeliki, Mavrodimitraki, Eleni, Metaxas, Panagiotis, Nikova, Alexandrina, Psarologos, Michail, Sotiropoulou, Maria, Stranjalis, George, Albanopoulos, Konstantinos, Kondilis, Panagiotis, Vrakopoulou, Gavriella Zoi, Chrysovergis, Aristeidis, Chrysovitsiotis, Georgios, Giotakis, Evangelos, Kanellopoulou, Vasiliki, Kyrodimos, Efthymios, Larentzakis, Andreas, Pantos, Pavlos, Papanikolaou, Vasileios, Potamianos, Spyridon, Theodoropoulos, Charalampos, Triantafyllou, Alexandra, Triantafyllou, Tania, Georgousi, Kleoniki, Panagiotou, Peter, Avramidis, Emmanouil, Babis, George, Zafeiris, Evangelos, Antoniou, Afroditi, Bessias, Nikolaos, Maras, Dimitris, Papas, Theofanis, Roditis, Konstantinos, Tsagkos, Ioannis, Tsiantoula, Paraskevi, Alexandrou, Andreas, Baili, Efstratia, Charalabopoulos, Alexandros, Dimitroulis, Dimitrios, Dorovinis, Panagiotis, Garoufalia, Zoe, Kanavidis, Prodromos, Karavokyros, Ioannis, Karydakis, Lysandros, Kykalos, Stylianos, Kyros, Eleandros, Machairas, Nikolaos, Mastoraki, Aikaterini, Nikiteas, Nikolaos, Papalampros, Alexandros, Schizas, Dimitrios, Skotsimara, Antonia, Stamopoulos, Paraskevas, Syllaios, Athanasios, Terras, Alexis, Tomara, Nefeli, Tsourouflis, Gerasimos, Vagios, Ilias, Zografos, Constantinos, Apostolou, Konstantinos, Georgopoulos, Nikolaos, Antoniou, Theofani, Antzaka, Christina, Falara, Areti, Fragoulis, Socrates, Ftikos, Panagiotis, Matsouka, Fedra, Perreas, Konstantinos, Rellia, Panagiota, Samara, Evangelia, Smirli, Anna, Tasouli, Androniki, Thanopoulos, Apostolos, Chalkias, Petros Loukas, Dedemadi, Georgia, Mourmouris, Panagiotis, Skolarikos, Andreas, Theochari, Nikoletta, Tzelves, Lazaros, Gaitanakis, Stylianos, Milas, Theodoros, Theodorakis, Emmanuel, Karona, Paraskevi, Kastanaki, Pagona, Tzouganakis, Angelos, Agalianos, Christos, Tsouknidas, Ioannis, Xenakis, Andreas, Chrysos, Emmanuel, Lasithiotakis, Konstantinos, Nikolouzakis, Taxiarchis, Xenaki, Sofia, Xynos, Evangelos, Lostoridis, Eftychios, Nagorni, Eleni‐aikaterini, Pujante, Antonio, Tourountzi, Paraskevi, Aggeliki, Al, Baxevanidou, Kyriaki, Bouliaris, Konstantinos, Efthimiou, Matheos, Kalfountzos, Christos, Koukoulis, Georgios, Lachanas, Vasileios, Petropoulos, Konstantinos, Tsitiridis, Ioannis, Angelis, Fragkiskos, Arnaoutoglou, Eleni, Baloyiannis, Ioannis, Bareka, Metaxia, Bouronikou, Anna, Christodoulidis, Gregory, Daponte, Alexandros, Fergadi, Maria, Gkolias, Nick, Gkrinia, Eleni, Hajiioannou, Jiannis, Kalogritsas, Nikos, Karoni, Eleni, Korais, Christos, Krestinidis, Giorgos, Ktisti, Antigoni, Magouliotis, Dimitrios, Maiou, Charikleia, Malizos, Konstantinos, Minasidou, Maria, Ntalouka, Maria, Ntziovara, Anna Maria, Palla, Effrosyni, Perivoliotis, Konstantinos, Saini, Fani, Samara, Athina, Saratziotis, Athanasios, Skoulakis, Charalampos, Solomi, Efthymios, Stamoulis, Konstantinos, Terzoudis, Christos Dimitrios, Tsironi, Evangelia, Tzovaras, George, Vallianou, Kyriaki, Zacharoulis, Dimitris, Ziogkou, Anna, Δακής, Κωνσταντί__ς, Elias, Liolis, Maroulis, Ioannis, Mulita, Francesk, Plachouri, Kerasia‐maria, Vailas, Michail, Doitsidis, Charalampos, Filo, Eva, Gkalonaki, Ioanna, Kogia, Eleni, Kontopoulou, Konstantina, Mitroudi, Magdalini, Panteli, Christina, Patoulias, Ioannis, Semkoglou, Olga Ioulia, Sfoungaris, Dimitrios, Valioulis, Ioannis, υτσ_υ μης, Γι ωργος, Astreidis, Ioannis, Christidis, Panagiotis, Ioannidis, Orestis, Loutzidou, Lydia, Mantevas, Antonis, Paraskevopoulos, Konstantinos, Tatsis, Dimitris, Athanasiadis, Apostolos, Dagklis, Themistoklis, Kalogiannidis, Ioannis, Kapetanios, Georgios, Mamopoulos, Apostolos, Margioula‐siarkou, Chrysoula, Petousis, Stamatios, Tsakiridis, Ioannis, Anthoulakis, Christos, Christou, Chrysanthos, Fantakis, Antonios, Iordanidou, Eirini, Kaselas, Christos, Panagiotidou, Sousana, Papadopoulos, Vasileios, Papavasiliou, Kyriakos, Piachas, Athanasios, Siasios, Ioannis, Spyridakis, Ioannis, Theodoridis, Theodoros, Tooulias, Andreas, Tsiridis, Eleftherios, Tsopozidi, Maria, Alemán, María, Brolo, Estuardo, Lemus, Ana Lucia, Greenberg, Jennifer, Chew, Krisna Mishel Morales, Oliva, José Rodrigo, Lima, María Alejandra De León, Muralles, Ismar Lopez, Solares, Felipe, Ajcip, Gaby, Anton, Claudia, Cojulun, Jose, Flores, Mario‐andrés, José, Noriega, Paiz, Carlos Adolfo Marroquín, Morales, Steffanía, Najera, Ramiro, Lorenzana, Eduardo Quiñónez, Rivera, Pablo, Rodas, Lesly, Santos, Victor, Sosa, Dianne, Ybarra, Natalia, Cajti, José David Pérez, Régil, Carlos, Osorio, Walter A, Arriola, Rember Rosales, Talé‐rosales, Luis‐fernando, Herrera, Danilo, Rodríguez, Servio Tulio Torres, Villeda, Sergio Alejandro, Anicetti, Joshua, Medina, Andrea Michelle Lowey, Ardebol, Javier, Barillas, Kathia, De Leon, Francis, Recinos, Salvador, Marroquin‐alpirez, Miguel‐angel, Yax, Yessica, Hon, Sophie, Liu, Yuk Ho, Liu, Alex Qinyang, Liu, Shirley, Chiu, Hei Tung Natalie, Chow, Chi Man Tom, Hau, Victor, Ho Wai, Ip, Mak, Brian, Mok, Chung Ying, Dennis, Ng, Siu, Yin Yu Eva, Wong, Kiu Fung, Jingya Jane, Pu, Yu‐xiong, Su, Au‐yeung, Kit Ying, Chan, David Yuen Chung, Chan, Albert, Chan, Shannon Melissa, Chang, Tsz Ching, Chiu, Tor Wo, Chiu, Wang Kei, Zhexi, He, Man Fung, Ho, Kevin Ki Wai, Ho, Jacky Yan Kit, Ho, Kung, Janet Wui Cheung, Lam, Cheuk Ho, Lau, Rainbow W. H., Ling, Samuel Ka Kin, Lok, Hon Ting, Mak, Tony Wing Chung, Chi‐fai, Ng, Simon, Ng, Kelvin Kwok‐Chai, Ng, Calvin S. H., Ng, Ong, Michael Tim Yun, Tan, Teresa, Tang, Sui Fan, Teoh, Jeremy Yuen‐Chun, Teoh, Anthony, Tsui, Bess Siu Yan, Wong, George Kwok Chu, Wong, Randolph, Wong, Kwok Chuen, Yee, Chi Hang, Antal, Zsuzsanna, Kalman, Attila, Voros, Peter, Bahrehmand, Kiarash, Echim, Timea, Novak, Zoltan, Sztipits, Tamás, Bihari, Laszló ádám, Hidi, László, Piros, Laszlo, Rózsa, Balazs, Sotonyi, Peter, Szatai, Lilla, Herczeg, György, Pordány, Bálint, Tornyi, Fanni, Dede, Kristof, Egyed, Tamás, Saftics, György, Kulcsicka‐gut, Judit, Sipos, Zsófia, Toth, Dezso, Patel, Bhavin, Majmudar, Hardil, Mankad, Saptak, Pathan, Sohilkhan, Sharathkumarkl, L, Sasatti, Lokesh, Mahankali, Subramanyam, Annayappa, Santhosh Kumar Sampengere, Agrawal, Tulika, Anandan, Premkumar, Baindur, Aditya, Manjunath, Bd, Savitha, C, Anitha, G S, Harigond, Sandeep, Tejeswini, K K, Kesarla, Venkatesh, Manangi, Mallikarjuna, Hareesh, P B, Ranjan, Jyothi K R, Shetty, Athish, Chikkanayakanahalli, Santhosh Shivashankar, Sunil, Tanvi, Syamala, Shreya, Tharanath, Kavya, Atal, Aditya, Rajagopal, Niranjana, Srinath, B S, Vinod, Nk, Thirumanikandan, P L, Mishra, Nitu, Shrivastava, Sushruta, Wadhwani, Rekha, Ahmad, Reyaz, Haq, Zainab Ahmad, Behera, Prateek, Dhurwe, Ritika, Haq, Rehan, Jain, Vaibhav, Jain, Anuj, Karna, Sunaina, Pushpalatha, Kameshwarachari, Raj, Sumit, Santoshi, John Ashutosh, Singh, Pooja, Verma, Virendra, Waindeskar, Vaishali, Yadav, Moorat Singh, Aziz, Zaheda, Chakraborty, Koyel, Chappity, Preetam, Das, Gurudip, Datta, Debajyoti, Jena, Saubhagya Kumar, Kar, Madhabananda, Khuntia, Susanta, Kumar, Pankaj, Kumar, Ravi, Aswathi, Kv, Mishra, Abhijeet, Mishra, Swastik, Mittal, Yash, Muduly, Dillip, Panda, Ritesh, Panigrahi, Sibasish, Parija, Sucheta, Patra, Saroj, Rout, Bikram, Sahu, Rabi, Sarkar, Saurav, Singh, Sweta, Sudha, Sanjibani, Sultania, Mahesh, Tripathy, Sujit, Varghese, Paulson, Kansay, Rajeev, Kaushik, Robin, Singh, Simrandeep, Gupta, Sunil Kumar, Khare, Siddhant, Kumar, Vishal, Mohindra, Sandeep, Patil, Ninad, Salunke, Pravin, Savlania, Ajay, Singh, Kavindra, Pradeep Krishna, Rv, Narasimhan, Gomathy, Rela, Mohamed, Appukuttan, Akhila, Goudar, Swati, Mallick, Shweta, Titus, Christi, Chidambarasamy, Ezhir Selvan, Madhavan, Devdas, Murugesan, Anandan, Narayanasamy, Kuppurajan, Barani Kumar, P B, Rajan, Firoz, Vijayaragavan, Paari, Kumar, Arvind, Borthakur, Biplob, Chauhan, Tapan Singh, Govil, Akhil, Gupta, Shubhra, Hanjoora, Vijay Mohan, Sharma, Ashish, Srivastava, Aseem, Tiwari, Saurabh, Vishwani, Vartika, Pendyala, Karuna Sree, Prasad, Navakoti, Bothra, Jyoti, Deb, Mainak, Herle, Koushik, Jayaram, Harish, Kannaiyan, Lavanya, Krithiga, Abirami, Mukta, W, Nagpal, Pooja, Pathak, Prachi, Banerjee, Sumit, Chaudhary, Ramkaran, Choudhary, Gautam Ram, Chugh, Ankita, Dixit, Pawan, Elhence, Abhay, Gahlot, Nitesh, Garg, Mayank, Ghuman, Navdeep Kaur, Jha, Deepak, Kala, Prakash, Kaur, Amanjot, Madduri, Vijay, Pandey, Himanshu, Pareek, Puneet, Pathak, Manish, Rathod, Kirtikumar J, Rodha, Mahaveer Singh, Saxena, Rahul, Sharma, Naveen, Shekhar, Shashank, Singh, Mahendra, Singh, Pratibha, Suryanarayanan, Bhaskar, Vishnoi, Jeewan Ram, Amin, Shivang, Kumar, Rohit, Sharma, Tanishq, Murugesan, Kesavan, Ramasamy, Abhinav Balachandar Subbiah, Chatterjee, Debarshi, Gerber, C Gerber, Naskar, Upasana, Aggarwal, Gaurav, Agrawal, Sanjit Kumar, Ahmed, Azaz, Gupta, Sujoy, Jain, Prateek, Jain, Deepak, Kewlani, Vishal, Pipara, Amrit, Priya, Noopur, Raja, Roopak, Shakya, Sudip, Thambudorai, Robin, Kharkongor, Dimple, Agarwal, Anjoo, Akhtar, Naseem, Anand, Akshay, Asnani, Mona, Chaturvedi, Arun, Chaurasia, Akhilanand, Enny, Loreno E., Garg, Surabhi, Gupta, Sameer, Jaiswal, Anoop Kumar, Jaiswal, Somil, Jaware, Yashpal, Kala, Navneet, Karnatak, Ruchi, Kaur, Apjit, Kumar, Vijay, Kumar, Manoj, Kumar, Ambrish, Kumar, Upander, Shrivastava, Amit Kumar, Mehrotra, Seema, Mishra, Brijesh, Mishra, Anand, Namrata, Null, Ojha, Bal Krishna, Ozair, Ahmad, Pal, Uma Shanker, Pandey, Amita, Raja, Nancy, Ramakant, Pooja, Roy, Ashutosh, Sachan, Rekha, Sankhwar, Satyanarayan, Sankhwar, Pushp, Sarin, Divya, Shukla, Ayushi, Singh, Sushil, Singh, Mohit, Singh, Kul Ranjan, Singh, Renu, Singh, Uma, Singh, Urmila, Solanki, Vandana, Sonkar, Abhinav Arun, Srivastava, Chhitij, Suryawanshi, Parijat, Tewarson, Vivek, Verma, Rajat, Verma, Manju Lata, Yadav, Awdhesh, Chand, Gyan, Chanthar, K. M. M. 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Giorgio, Fappiano, Francesca, Pacilio, Carlo Alberto, Solaini, Leonardo, D’Andrea, Giancarlo, Lavalle, Laura, Picotti, Veronica, Barberis, Andrea, Filauro, Marco, Santoliquido, Matteo, Aprile, Alessandra, Barra, Fabio, De Rosa, Raffaele, Diaz, Raquel, Ferrero, Simone, Fregatti, Piero, Gustavino, Claudio, Iester, Michele, Kratochwila, Chiara, Massobrio, Andrea, Pertile, Davide, Scabini, Stefano, Scovazzi, Umberto, Soriero, Domenico, Sparavigna, Marco, Traverso, Carlo, Vagge, Aldo, Gambardella, Denise, Tedesco, Manfredo, D’Ugo, Stefano, Depalma, Norma, Spampinato, Marcello Giuseppe, Airoldi, Angelo, Brivio, Ariberto, Chiarelli, Marco, Gibelli, Ludovica, Giulia, Bonfanti, Grandi, Samuele, Pesenti, Giovanni, Tagliabue, Fulvio, Zago, Mauro, Lenzi, Riccardo, Matteucci, Jacopo, Muscatello, Luca, Colletti, Gaia, Confalonieri, Marco Guido, Costanzi, Andrea, Frattaruolo, Colomba, Locatelli, Andrea, Monteleone, Michela, Badessi, Giorgio, Caffo, Maria, Caruso, Gerardo, Cucinotta, Eugenio, Germano, Antonino Francesco, Mazzeo, Carmelo, Bertoglio, Camillo Leonardo, De Martini, Paolo, Ferrari, Giovanni, Giani, Alessandro, Lombardi, Pietro Maria, Mazzola, Michele, Baldari, Ludovica, Bissacco, Daniele, Boni, Luigi, Cassinotti, Elisa, Domanin, Maurizio, Pignataro, Lorenzo, Torretta, Sara, Trimarchi, Santi, Armellin, Daniele, Basato, Silvia, Bernardi, Laura, Bunino, Francesca, Capretti, Giovanni, Carrano, Francesco Maria, Castoro, Carlo, Colombo, Giovanni, Costantino, Andrea, De Lucia, Francesca, De Virgilio, Armando, Di Bari, Matteo, Ferreli, Fabio, Gaino, Francesca, Gramellini, Marco, La Raja, Carlotta, Malvezzi, Luca, Marano, Salvatore, Mercante, Giuseppe, Milana, Flavio, Nappo, Gennaro, Peros, Georgios, Pirola, Francesca, Rossi, Vanessa, Russo, Elena, Spriano, Giuseppe, Tamburello, Sara, Zerbi, Alessandro, Aiolfi, Alberto, Bona, Davide, Sozzi, Andrea, Adamoli, Laura, Ansarin, Mohssen, Bertolaccini, Luca, Cenciarelli, Sabine, Chu, Francesco, De Berardinis, Rita, Romario, Uberto 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Andreani, Lorenzo, Antonio, Darienzo, Aprile, Vittorio, Balestri, Riccardo, Benettini, Giacomo, Berrettini, Stefano, Bruschini, Luca, Chiarugi, Massimo, Coccolini, Federico, Colangeli, Simone, Cremonini, Camilla, Mencacci, Lodovica Cristofani, Dallan, Iacopo, De Santi, Silvia, Di Franco, Gregorio, Di Girolami, Lorena, Fiacchini, Giacomo, Furbetta, Niccolò, Korasidis, Stylianos, Lucchi, Marco, Morandi, Andrea, Morelli, Luca, Musetti, Serena, Neri, Carlo Maria, Palmeri, Matteo, Picariello, Miriana, Porcelli, Francesco, Puccini, Marco, Roffi, Nicolo, Statuti, Erica, Tartaglia, Dario, Tonelli, Alberto, Vianini, Matteo, Baronio, Gianluca, Montuori, Mauro, Pinotti, Enrico, Basso, Stefano Maria Massimiliano, Maffeis, Federica, Ubiali, Paolo, Aguzzoli, Lorenzo, Coiro, Saverio, Falco, Giuseppe, Mandato, Vincenzo Dario, Mastrofilippo, Valentina, Mele, Simone, Baldi, Caterina, Corbellini, Carlo, Sampietro, Gianluca Matteo, Dugo, Massimo, Garino, Mauro, Marafante, Chiara, Masciandaro, Antonio, 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Francesco, Altana, Cristian, Bussu, Francesco, Capobianco, Giampiero, Carta, Anna Giacomina, Ciccarello, Sandro, Cossu, Maria Laura, Cottu, Pietrina, De Riu, Giacomo, Dessole, Salvatore, Dessole, Francesco, Dettori, Salvatora, Doria, Carlo, Fancellu, Alessandro, Feo, Claudio F, Ginesu, Giorgio Carlo, Giuliani, Giuliana, Iannuccelli, Marco Giuseppe, Madonia, Massimo, Mancino, Roberto, Massarelli, Olindo, Meloni, Gianfranco, Milia, Fabio, Mulliri, Andrea, Perra, Teresa, Petrillo, Marco, Piras, Antonio, Piredda, Franco, Pisanu, Francesco, Porcu, Alberto, Rizzo, Davide, Sanna, Angelino, Scanu, Antonio Mario, Scognamillo, Fabrizio, Soma, Damiano, Tanca, Anna Rita, Tedde, Alessandro, Tedde, Matteo, Vaira, Luigi Angelo, Pazzi, Andrea Bartalini Cinughi, Samorani, Osvaldo Carpineto, Fusario, Daniele, Marano, Luigi, Oldrà, Gaia, Pesce, Anna Lisa, Piccioni, Stefania Angela, Resca, Luca, Ricchiuti, Vincenzo, Roviello, Franco, Savelli, Vinno, Abrate, Alberto, Bordoni, Pierpaolo, Bosio, Lorenzo, 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Rinaldi, Mauro, Ruffini, Enrico, Salizzoni, Stefano, Bardelli, Laura, Berselli, Mattia, Borroni, Giacomo, Cocozza, Eugenio, Desio, Matteo, Elisa, Bottazzoli, Ietto, Giuseppe, Iori, Valentina, Iovino, Domenico, Livraghi, Lorenzo, Marchionini, Valentina, Megna, Stefano, Nahal, Emma Amal, Palumbo, Mara, Quintodei, Valeria, Zullo, Alessandra, D’Alimonte, Lucrezia, Pirozzolo, Giovanni, Vignotto, Chiara, Campagnaro, Tommaso, Caravati, Andrea, Conci, Simone, De Cristofaro, Carlotta, Gecchele, Gabriele, Giuliani, Tommaso, Graziosi, Jacopo, Guglielmi, Alfredo, Paiella, Salvatore, Pedrazzani, Corrado, Pollini, Tommaso, Rattizzato, Simone, Ruzzenente, Andrea, Salvia, Roberto, Turri, Giulia, Bacchion, Matilde, Butturini, Giovanni, Casaril, Andrea, Giardino, Alessandro, Impellizzeri, Harmony, Inama, Marco, Isabella, Frigerio, Moretto, Gianluigi, De Zuanni, Marco, Deiana, Enrica, Guglielmo, Mario, Broglia, Alessandro, Casarini, Claudia, Zingaretti, Caterina Costanza, Bonaldi, Marta, Cesana, Giovanni, Mastriale, Francesco, Olmi, Stefano, Fukami, Matteo Uccelli Yasuyuki, Saito, Takuya, Sano, Tsuyoshi, Hirai, Naoki, Hirota, Kazuyoshi, Kushikata, Tetsuya, Oyama, Tasuku, Saito, Junichi, Ishibashi, Katsuhiko, Kamiyama, Mizue, Son, Kyongsuk, Tarao, Kentaroh, Yamada, Takayuki, Shiga, Toshiya, Aze, Chisaki, Deguchi, Yoshihiko, Hasegawa, Hirotoshi, Hoshino, Tatsuki, Innami, Yasushi, Inoue, Hiroyuki, Ito, Shingo, Nomura, Takeshi, Ogihara, Tomomi, Okada, Reina, Ouchi, Takashi, Sekiya, Yuri, Tachibana, Keikoku, Takano, Emi, Yamamoto, Masae, Matsuda, Shuko, Matsuki, Yuka, Shigemi, Kenji, Hiraki, Teruyuki, Inoue, Yui, Jotaki, Shosaburo, Abe, Tatsuro, Eto, Masatoshi, Inokuchi, Junichi, Kashiwagi, Eiji, Kinoshita, Fumio, Kobayashi, Satoshi, Lee, Ken, Matsumoto, Takashi, Monji, Keisuke, Naganuma, Hidekazu, Shiota, Masaki, Takeuchi, Ario, Obara, Shinju, Takatsuki, Saori, Tanaka, Saori, Iida, Koji, Kagawa, Kota, Neshige, Shuichiro, Chaki, Tomohiro, Hirata, Naoyuki, Kazuma, Satoshi, Kimizuka, 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Mieko, Hirano, Kouichi, Kobayashi, Yoichi, Matsuki, Ryota, Matsumoto, Hironori, Motoyasu, Akira, Nakazawa, Harumasa, Noguchi, Hikari, Okamura, Kaio, Ono, Motoaki, Seki, Hiroyuki, Sunami, Eiji, Tajima, Atsushi, Tanigaki, Shinji, Uzawa, Kohji, Watanabe, Hidenobu, Furuhata, Yukari, Toyama, Satoshi, Uchida, Tokujiro, Enomoto, Yutaka, Furukawa, Yuri, Hasumi, Yoko, Hirota, Jinso, Iida, Katsuyuki, Ikeda, Shingo, Ikeda, Tatsuhiko, Kawamata, Natsuko, Kawasaki, Yosuke, Koizumi, Minako, Kono, Yoshiharu, Kuzuhara, Shigeki, Maeda, Junichi, Moriyama, Mai, Nagamoto, Shoichi, Nakanishi, Rinako, Noda, Michio, Seichi, Atsushi, Takahashi, Shintaro, Takashi, Kobayashi, Takeda, Misuzu, Tanakura, Kenta, Terajima, Katsuyuki, Tsuji, Munechika, Ueshima, Chiharu, Yamamoto, Naoya, Yamamoto, Mari, Yokota, Toshiya, Yoshioka, Yuki, Yuri, Sakoh, Iwata, Shintaro, Kawai, Akira, Osaki, Shuhei, Ishikawa, Masashi, Iwasaki, Masae, Morita, Tomonori, Hirooka, Reina, Nakata, Yoshinori, Sawamura, Shigehito, Ishida, Yusuke, Kawachi, Aya, Kobayashi, Takayuki, Nagashima, Fumiaki, Suzuki, Naoki, Ando, Kohei, Miyazawa, Noriko, Tanaka, Yukio, Abuissa, Khatab, Aljabali, Alaa, Almasri, Amal, Alrabadi, Mera, Alshara, Rana, Alzghoul, Yasmeen, Alzughoul, Ahmed, Freihat, Ali, Jeitan, Emran, Owais, Qais, Smadi, Aseel, Abukhadra, Mahmoud, Abunawas, Huthifa, Al‐azzam, Abdallah Ahmed Mezel, Aladaileh, Ammar, Albadawi, Ismail, Alhawatmeh, Mohammad, Alkhaza’Leh, Mohannad Yaser, Alneimat, Roaa Salem Jwaid, Alwahedy, Saba, Alwardat, Abdel Rahman Mohannad Ahmad, Dhoon, Slsabela, El‐qawaqzeh, Khaled, Hrerat, Tarteel, Jaradat, Enas, Mubaydeen, Teeba, Sarayrah, Husam, Tarawneh, Mohammad Abdel Elah A., Karasneh, Mohammad Yousef, Zurgan, Amany, Alassaf, Mohammad, Alzraikat, Sayel H., Amarin, Justin Z., Hijjawi, Ahmed, Suradi, Haya H., Zaghlol, Louay Y., Abdalah, Ahmad, Abdallah, Ghaida, Tarieh, Ammar Abu, Abu‐libdeh, Tareq, Abualteen, Faisal, Al Abdallah, Murad, Al Bdour, Zakaria, Al Dahabrh, Seif, Al‐kasaji, Farah, Ali, Zaid Al‐sheikh, Al‐thaher, Mohammad, Alnajjar, Tareq, Alqedrh, Mohannad, Alsaleh, Mohammad, Alzaatreh, Mohammad, Amayreh, Ghandi, Ayasra, Yazeed, Eid, Ahmad, Ghayada, Ibrahim, Moh’d Ahmed Hasanein, Khaled, Hassouneh, Anas, Hijazeen, Raid, Hmeidan, Majedah, Khaled, Ahmed, Khasawneh, Barihan, Kifayeh, Omar, Lafi, Yasser, Seba, Jasem, Semrin, Qusai, Sma, Fda, Theab, Mohammad, Tumeh, Haitham, Zaid, Muna Aba, Abazeed, Alaa, Abbad, Bader, Abbadi, Osaid, Abu‐ishkerih, Nizar, Al‐osta, Malk, Al‐zyadat, Reham, Alawneh, Bashar Omar Falah, Alhattab, Majd, Alkurdieh, Mohd Mujahed, Awwad, Ziad, Hammouri, Mohammad, Hussein, Hamzeh, Khader, Sereen, Khalil, Mariam, Mansour, Omar, Othman, Ahmad, Qandeel, Haitham, Saleem, Mohammad, Souri, Fouad, Tahboub, Ahmad, Tayyem, Raed, Abdallah, Munir, Abdel‐hafez, Ibrahim, Obead, Hamza Abu, Abudari, Hadeel, Abuhamour, Ehab, Abusadah, Samer, Al‐azzeh, Nimer, Al‐adwan, Sofian, Al‐darabah, Ali, Al‐qannas, Mohammad, Albaba, Basil, Alradawneh, Qutaiba, Amaireh, Mohammad, Ashour, Subhi, Chabaan, Reem, Eskander, Ammar, Fawzi, Ahmad, Haij, Manal, Hamad, Hisham, Hamdan, Haya, Hamss, Ahmed, Hassouneh, Esraa, Hyasat, Ayah, Ibrahim, Zainab, Jamaliah, Saja, Khalil, Mohammed, Massad, Anas, Mohamed, Ishak, Qandeel, Mahmoud, Qasrawi, Dalia, Raggad, Mahmoud, Rifai, Ebaa, Semreen, Nedal, Shehada, Reham, Shorman, Marwan, Al‐shibi, Abdallah, Alsa’Afin, Shatha, Bani‐hani, Morad, Nimer, Bahaa, Nofal, Sandra, Qaraqe, Layth, Salameh, Mohammed, Saleh, Ma’Moun, Sanjuq, Ghaidaa, Sharabi, Alaa, Sweiti, Alaa, Yaghmour, Jamal, Zaza, Sabri, Alhindi, Rahaf, Baninasr, Eman, Al‐masri, Mahmoud, Al‐najjar, Hani, Alawneh, Fade, Al‐latayfeh, Motasem, Al‐shudifat, Abdel‐ellah, Ahmad, Abd Almonem Shaikh, Abdeljalil, Abdelkarim, Abdelrahman, Haneen, Abdulmalek, Abdulmalek, Abedalqader, Lina, Abed, Laith Abu, Al Smadi, Omar, Alarood, Salameh, Allouzi, Mohammad, Almansour, Maha, Almi’Ani, Sari, Alsaiad, Abdulhakim, Alshaikh, Khaled, Androus, Farah, Awbakh, Mirna, Azzam, Belal, Yasin, Hammam Bany, Daoud, Maher, Dawod, Lujain, Dawod, Omar, Elmusa, Reem, Fadli, Saba, Hammad, Farah, Hunaiti, Majd, Muhtaseb, Mahmoud, Owaimer, Rawan, Qulaghassi, Zaki, Romman, Saleh, Saket, Rawand, Sharawi, Said, Tawalbeh, Alaa, Al‐howthi, Mohammed, Ababneh, Laila, Ababneh, Roba, Za’Nouneh, Faris Jamal Abu, Al DHOUN, Sajedah, Al Khassawneh, Ahmad, Al Sharie, Ahmed, Al Shraideh, Ayah Ahmad, Al‐dabaa, Tawfik, Al‐jarrah, Salsabeel, Al‐jarrah, Hothaifa, Al‐othman, Hadeel, Alaradi, Zuhair, Alshannaq, Qutaiba, Alsulaiman, Rima, Alzaqh, Motasem, Alzu’Bi, Yazan, Audat, Ziad, Bahhour, Mohammad, Bdour, Saja, Khatatbeh, Roa, Marji, Fares, Mazahreh, Tagleb, Nail, Dina, Nuseir, Amjad, Rabab’Ah, Asmaa, Sawadi, Taher, Zidan, Ghina, Muhfouz, Dima Abu, Nael, Abdullah, Qasim, Ahmad, Al‐jarrah, Amar, Rawagah, Faisal, Abu Ismail, Dima Y, Al‐dolat, Wedad, Alzoubi, Mai, Alzoubi, Malak, Alzu’Bi, Mu’Taz, Asha, Ruba, Guboug, Ali, Hussein, Hasan, Rawashdeh, Shireen, Sanwar, Mohammad, Ababneh, Adnan, Abu‐eisheh, Basil, Alhami, Haneen Ahmad, Al Dwairi, Saif Aldeen, Al Shurman, Hana’, Al Yahya, Zakaria, Al‐atiyah, Hussam, Al‐balas, Hasan, Aljaiuossi, Anas, Alqawasmi, Shatha, Alqudah, Sadeel, Alshourman, Mahmoud, Hamad, Abdulsalam Bani, Issa, Anas Bany, Ennab, Raed, Hamdoni, Sara, Hijazi, Zaid, Khafaja, Ali, Mraiyan, Mohamed, Obeidat, Riyad, Olaywah, Dina, Qudah, Mohamad, Talal, Mhamdd, Aidarov, Askar, Sarmenova, Aisulu, Kodasbaev, Almat, Sakhov, Orazbek, Tanabayeva, Shynar, Amrayev, Sultan, Dzhumabekov, Berik, Malgazhdarov, Maulen, Tezekbaev, Kanat, Kukubassov, Yerlan, Satanova, Alima, Mwachiro, Michael, Parker, Robert, Simel, Ian, Mohammedali, Shamshuddin, Mwaria, Claude, Obure, Ralph, Shah, Sayed Shah Nur Hussein, Hirani, Chetan, Kibunyi, Muthoni, Mailu, Claire, Mwangi, Victor, Ogenya, Roy, Osea, Lydia, Cheruiyot, Davies, Hirsi, Omar, Muiru, Carolyne, Wanjara, Samuel, Kim, Chang Woo, Lee, Suk Hwan, Almulla, Ahmad, Dashti, Mustafa, Elghany, Omar, Sultan, Abdullah, Al‐mahmeed, Husain, Alabbad, Jasim, Albader, Ibtisam, Aldalal, Shuaib, Baba, Mahdi, Abdulsalam, Fareed, Alhajri, Naser, Alwael, Athari, Ayele, Brook, Marie, Hatem, Zaitoun, Ahmed, Alali, Ahmad M., Alkhamis, Ahmed, Alozairi, Ous, Almazeedi, Sulaiman, Alsabah, Salman, Abdelkarim, Mostafa, Al Rashed, Asmaa, Al Subaie, Saud, Al‐shaiji, Tariq, Al‐terki, Abdullatif, Alhunaidi, Omar, Aljewaied, Ali, Alzamel, Khaled, Farag, Ahmed, Hayati, Hussein, Termos, Salah, Wood, Sarah, Al‐gilani, Maha, Al‐sihan, Mutlaq, Alotaibi, Haifa, Lobovs, Dmitrijs, Pcolkins, Andrejs, Sivins, Armands, Apse, Ingus Arnolds, Berga, Annija Evelīna, Ivanova, Anna, Demicevs, Jevgenijs, Ivanovs, Igors, Kaminskis, Aleksejs, Opincans, Janis, Pāvulāns, Jānis, Rudzāts, Agris, Udre, Anna, Dbouk, Samer, Farfour, Imadeddine, Rakka, Mohamad, Antonios, Ingrid, El Hage, Joe, Hage, Stephanie, Haiby, Lea, Kahi, Hiba, Lichaa, Anthony, Moussa, Rita Milan, Salameh, Michel, Sarkis, Riad, Albaini, Obey, Haykal, Tony, Safadi, Bassem, Abou‐abbass, Hussein, Al Makari, Reem, Al Zein, Zeina, Baidoun, Mariam, Itani, Rania, Owiedat, Mustafa, Abdel Sater, Ali H., Akl, Michel, Badran, Nour, El Mustapha, Sara, Fatouh, Fathallah, Ghoussoub, Youssef, Saad, Nader, Serhan, Fatima, Souleiman, Bassem, Alame, Walid, Ghiya, Peter, Ibrahim, Firas, Abdallah, Rasha, Kassab, Mohamad B., Karout, Samar, Aya Abdul, Al, Chaaban, Hilal, Fakih, Ghinwa, Haj‐ibrahim, Huzifa, Awad, Rabih, El Assaad, Hadi, Alfeqeeh, Ahmed, Muftah, Hosam, Abdulrahman, Taha, Ahseen, Naeimah, Abunaaja, Hayat Omar, Abdulmalik, Abdulmuez, Al Gasi, Abd El Jawad, Alsaeiti, Sara, Elkhafeefi, Fatimah, Elrefai, Nasre, Ahmad, Rofida, Alhouni, Tarek, Alkarky, Safya, Alkeelani, Hana, Alkuwafi, Rauoof, Benhariz, Rema, Bettamer, Nagat, Busarira, Musa, Bushaala, Hassan, Diryaq, Tariq, Elbargathe, Osama, Eldarat, Tarik, Elfadli, Mustafa, Elfitori, Jamael, Elmahgoub, Asma, Elsahti, Reem, Hassan, Yosef, Hussain, Fathi, Mirsal, Taha, Mohammed, Marwa, Saad, Ebtesam, Hadad, Haifaa Il, Mosabha, Mostafa, Alhaje, Awatif, Haron, Aaya, Alsuwiyah, Suhir, Hamed, Mona, Khel, Samer, Omar, Sana, Yousef, Rowaida, Abdelmalik, Abubaker, Abosnaina, Yahya, Abuhlaiga, Ma’Aly, Abushahma, Ahmed Omar, Aldelensi Alzubi, Alhosen Saleh M, Aljanfi, Asma, Alnehum, Mohamed Alnaser, Alzedam, Ahmad, Delhen, Malik, Maderi, Galia, Matoug, Faisel, Mohammed, Burooj, Sawalem, Mohamed, Jahan, Alhadi, Jahan, Abdussalam, Alazabi, Basma, Alezabi, Bahauldin, Alazabi, Mona Masaud Amro, Egdeer, Amin Salem Ahmed, Sefi, Fatma, Kamoka, Elhusain, Salamah, Abdulrauf, Abdalhadi, Alya, Abdeewi, Saedah, Alhadad, Marwah, Awrayit, Ahmed, Eshnaf, Mabroka, Yahmad, Mohammad, Abudher, Abdulhafid, Elamin, Faisl, Abojeila, Farah, Aliwa, Mohamed, Jouira, Rayet Al Islam Ben, Shagour, Sana, Altobal, Ahmed, Aljuroushi, Omar, Almadani, Hadeel, Attia, Hajer, Eljali, Amal Sharif, Emran, Ayyah, Omar, Mabruka, Salim, Radhwan, Samer, Ashraf, Abulshuwashi, Nayrouz Abdullah, Ben Khalifa, Emadeddin T M, Benabdalla, Hdaya Abdalla S, Elnageh, Hatem, Hammad, Ali, Abdullah, Duha Milad, Abusalem, Marwa, Esmael, Esraa Ben, Benmasoud, Fatma, Debri, Laila, Elmokhtar, Randa, Sheta, Manal Ezeddin Kamel, Elhabashi, Bushra Sayeh Mohamed, Younis, Balkees, Elmabrouk, Amna, Momen, Ahmed, Alzoubi, Abdalrahem Essied Alzubi, Ayad, Kusay, Hasan, Ameerah Mahdi Abraheem, Musrati, Fawzie, Abusannoga, Malek, Malek, Ans, Ajaj, Hatem, Abdulwahed, Eman, Aboubeirah, Mohammed, Alqurpaa, Aya, Alshareea, Entisar, Aribi, Sarra, Aribi, Tomather, Biala, Marwa, Ghamgh, Reem, Issa, Mohannned, Lamari, Amani Hamid, Mufth, Mohammed, Abboud, Omar Sudig, Hallalah, Muad Fathi Khalleefah Abu, Abumahara, Saleh, Aburima, Sarah, Adrees, Mohammed, Ahtash, Abdurahman, Al Shukri, Asmaa, Alameen, Hind, Alarabi, Rehab, Alarabi, Alarabi, Alelwany, Aisha, Alesmail, Abdulkarim, Algadi, Noran, Almaqrahi, Khuloud, Alosta, Hadel, Alsharedi, Mohamed, Bashir, Rasha, Ghrema, Mahmoud Ben, Nour, Sari Bin, Elbarouni, Sofian, Elhadi, Ahmed, Elkhadar, Abdulmohimen A, Elkouba, Esraa, Elmsherghi, Nabiha, Gammoudi, Abdulmohimen, Ghariba, Abdulraouf, Gjam, Fatima Zayed, Haidar, Arwa, Helal, Hala, Huwaysh, Mohammed, Alhadheeri, Ahmed Khalid, Kriem, Eslam, Osman, Halim, Ossman, Mohamed Ali, Shilfeet, Marwah, Turshani, Laila, Albishty, Nouran, Alhadi, Abdulmueti, Ali, Salem, Altoumi, Manal Ahmed, Bahroun, Sumayyah Ghayth, Younes, Eman, Atarabulsi, Hana, Elshaibi, Mohamed, Othman, Abdullmujeeb, Hasan, Hayat Ben, Hasan, Najat Shaban Ben, Hasan, Rabab Shaban Ben, Barauskas, Vidmantas, Dainius, Edvinas, Dambrauskas, Zilvinas, Dauksa, Albertas, Dekeryte, Inga, Gudaityte, Rita, Jasaitis, Kristijonas, Koženiauskaitė, Akvilė, Krasauskas, Virgilijus, Lukosiute‐urboniene, Ausra, Maleckas, Almantas, Riauka, Romualdas, Šlenfuktas, Vygintas, Svagzdys, Saulius, Urbonas, Kestutis, Vanagas, Tomas, Venclauskas, Linas, Venskutonis, Donatas, Zilinskas, Justas, Ambrazevicius, Marijus, Syminas, Vilius, Aliosin, Oleg, Cizauskaite, Agne, Eismontas, Vitalijus, Jurgaitis, Jonas, Mikutaitis, Vytenis, 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Mamisoa, Solo, Corinne Eulalie, Ralaizafindraibe, Tojomamy Herinjaka, Andofenohasina, Fanonjomahasoa Safiry, Rasataharifetra, Hanta, Razafindraibe, Vanona Barijaona, Herinirina, Angelin Sablon, Das, Andre, Ganapathy, Thanga, Gunarasa, Yohesuwary, Mariapan, Kalyani, Muniandy, Maathichsudhaar, Osman, Mohd Firdauss, Azmi, Mohd Azem Fathi Mohammad, Soh, Jien Yen, Zain, Wan Zainira Wan, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Chan, Kheng Hooi, Hayati, Firdaus, Johan, Syamim, Mah, Jin Jiun, Sriram, Ratha Krishnan, Subramaniam, Sentilnathan, Shahimi, Nur Shahirah Binti Muhammad, Hamdan, Khairul Hazim, Ibrahim, Mohd Razali, Muthkumaran, Guhan, Tan, Ju Ann, Thanapal, Mohana Raj, Aziz, Dayang Anita Abdul, Bastion, Mae‐lynn, Harun, Mohd Hairul Nizam, Imran, Farrah‐hani, Din, Norshamsiah Md, Zain, Ayesha Mohd, Mustapha, Mushawiahti, Nabil, Syed, Naffi, Ainal Adlin, Nazimi, Abd Jabar, Ramli, Roszalina, Soon, Bee Hong, Bal, Pavin, Cheng, Joo Qing, Draman, Mohd Rusdi, Fadzli, Ahmad Nazran, Ghauth, Sakina, Hung, Weipin, Jamaris, Suniza, Koh, Peng Soon, Krishnasamy, Sivakumar, Lee, Yeong Sing, Liew, Yew Toong, Lim, Jeffery Zk, Lim, Raymond Chung Siang, Lim, Hiong Chin, Pauzi, Siti Farhan Moh, Nah, Shireen Anne, Nair, Ashvin Krishna, Doris Sin Wen, Ng, Yong, Yuki Julius Ng We, Ramayah, Kamarajan, Saaid, Rahmah, Sanmugam, Anand, See, Mee Hoong, Seevalingam, Kanesh Kumaran, Sethi, Neha, Singaravel, Srihari, Zaidi, Syeda Nureena Syed Jafer Hussain, Tang, Chu Yik, Teoh, Li Ying, Wong, Kian Boon, Xavier, Ruben, Yahaya, Ahmad Shuib, Norhafiza, Ab, Rahman, Null, Islah Munjih, Ab, Rashid, Null, Aziz, Mohd Fahmi Abd, Rahman, Mohd Norhisham Azmi Abdul, Amjad, Nasser Muhammad, Alhadi, Shahidah Che, Elagili, Faisal, Kamarulzaman, Mohd Nazli, Nor, Azmi Md, Othman, Ahmad Faidzal, Sainal, Mohd Yusof, Sarif, Mat Salleh, Chua, Richelle, Ibrahim, Aini Fahriza, Ahmad, Abdul Rauf Bin, Lau, Yii Ling, Liew, Ka Yee, Palayan, Kandasami, Wong, Hui Yu, Zakaria, Jasiah, Aziz, Nor Azimah Abd, Rahim, Norazila Abdul, Rahman, Noorneza Abdul, Abdullah, Bahiyah, Sikkandar, Mohamed Faizal Bin, Firman, Fatin, Hazleigh, Nik Mohd, Kamarudin, Intan Kartika, Khalid, Shahril, Miswan, Mohd Fairudz Mohd, Zahid, Akmal Zulayla Mohd, Mustafa, Norasyikin, Obaid, Kadhim, Yahaya, Mohd Yusoff Bin Yahaya, Yusoff, Ahmad Ramzi, Andrejevic, Predrag, Myatt, Jeremy Borg, Brincat, Svetlana, Caruana, Clifford, Chircop, Kurt Lee, Chircop, Francesca, Chircop, Daniel Mario, Cini, Charles, Czok, Viktoria, Farrugia, Melanie, Grima, Gabriella, Almukhariq, Fatimah MJ Hassan, Muscat, Esther, Pisani, Darryl, Roshan, Mohsin Hassan Khan, Schembri, Nicholas, Shoukry, Mohamed, Spiteri, Neville, Tanti, Gilbert, Hasan, Ziad Aboharp, Soto, Alberto Bazan, Rubén, Cedillo Rodrìguez Jonathan, Zamudio, Gustavo Esteban Lugo, Gómez, David Gerardo Miranda, Meave, José Alfredo Pérez, Victor Pinto Angulo, Null, Aguilar, Antonio Rojas, Duran, Erik Efrain Sosa, Perez, Alejandro Vàzquez, Arroyo, Diego, Corona‐cruz, Jose, Martinez‐said, Hector, Medina‐franco, Heriberto, Mendez, Manuel, Suárez Ma, Teresa Moreno Y, Díaz, Dolores Orta, León Vázquez, Martha Patricia Pérez, Carvajal, Angélica Azucena Soto, Hernández, Fidel Soto, Stenner, Juan Ignacio, López, Adriana Valenzuela, Hernandez, Mauricio Rene, Romero, Rey Jesus, Hernandez, Aldo Bernal, Cortes‐flores, Ana Olivia, Valle, Carlos Jose Zuloaga Fernandez, Tinajero, Carlos Andres Colunga, Orozco‐perez, Jaime, Balboa, Laura Gabriela Peña, Yanowsky‐reyes, Guillermo, Torres, Víctor Hugo Alcalá, Camacho, Francisco José Barbosa, Perez, Irma Valeria Brancaccio, Calderon‐llamas, Miguel Angel, Gomez, Aldo Camacho, Cortes‐torres, Edgar‐joaquin, Cueva‐martinez, Esteban, Anguiano, Oscar Durán, Estrada, Isaac Esparza, Fierro‐rizo, Roberto, Becerril, Paola Flores, Orozco, Clotilde Fuentes, Castillo, Miguel García, Ojeda, Alejandro Gonzalez, Rubio, Ana Sofia Gonzalez, Rojas, Erick Alonso González‐García, Govea‐camacho, Luis Humberto, Barba, Jose Aldo Guzman, Peña, Juan Carlos Ibarrola, Martínez, César íñiguez, Llamas‐macias, Francisco Javier, Galaviz, Ruben Eduardo Morán, Nuño‐escobar, Cesar, Olvera‐flores, Oscar‐everardo, Osuna‐rubio, Jaqueline, Pérez‐navarro, Jose Victor, Prieto‐aldape, Rodrigo, Gonzalez, Luis Ricardo Ramirez, Sánchez, Marco Vinicio Ramírez, Reyes, Emilio, Romero‐limón, Olaya Moramay, Ruiz‐velasco, Carlos Beas, Martínez, José Antonio Sánchez, Sanchez‐villaseñor, Guillermo, Sedano‐portillo, Ismael, Gonzalez, Gabriela Ambriz, Moreno, Pedro Berrones Moreno Berrones, Alvarado, Ana Beatriz Calderon, Jesús Cárdenas Barón, José, Hernández, Araceli, Frutos, Francisco Javier León, Hernandez, Edgard Efren Lozada, Valencia, Eduardo Morales, Pérez, Karla Daniela, Bolanos‐morales, Francina, Herrera‐zamora, Julio, Santillan‐doherty, Patricio, Zavala, David Omar Arriaga, Campos, Salvador Francisco Campos, Carmona, Lizette, Nava, Antonio Galindo, Santos, Blanca, Cisneros, Juan Roberto Torres, Bozada‐gutiérrez, Katya, Herrera, Jose Jesus, Portillo, Mucio Moreno, López, Francisco Pérez, Trejo‐avila, Mario, Salazar, Carlos Valenzuela, Alvarez, Maria Regina, Cordera, Fernando, Rosa Abaroa, Marco Antonio, Gómez‐pedraza, Antonio, Hernandez, Roberto, Maffuz‐aziz, Antonio, Posada, José Antonio, Vidal, Carlos Robles, Beristain‐hernandez, Jose‐luis, Sada, Blas Eduardo Quintero, Heredia, Nicolás Uxmal Soruco, Anaya, Ernesto, Arceo‐olaiz, Ricardo, Sougarret, Bernardo Gutiérrez, Flores, Sonia Lopez, Ochoa Carrillo, Francisco J., Uribe, Raymundo Alfredo Pérez, Silva, Ludwigvan Adriano Bustamante, Lupián‐angulo, Arianne I, Martínez, Christian Enrique Soulé, García, Francisco César Becerra, Casillas, Ernesto Javier Guerrero, Uribe, Edgar, Arias, Nereida Esparza, Hernández‐nava, J. Mindy, Isla‐ortiz, David, Melchor‐ruan, Javier, Bañuelos, Esmeralda Romero, Salcedo‐hernández, Rosa, Vilar‐compte, Diana, Peniche, Paola Zinser, Aguilar Frasco, Jorge L., Alfaro‐goldaracena, Alejandro, Buerba, Gabriela Alejandra, Castro, Emma, Chan, Carlos, Cortes, Ruben, Dominguez‐rosado, Ismael, Lechuga, Daniel Garay, Herrera, Miguel, Hinojosa, Carlos, Lopez‐pena, Gabriel, Martos, Edgar, Mercado, Miguel ángel, Velázquez, Paulina Moctezuma, Moguel, Roberto, Oropeza, Mariano, Portugal, Emmanuel Peña Gómez, Posadas‐trujillo, Oscar Emmanuel, Salgado‐nesme, Noel, Jasso, Oscar Santes, Sarre, Catherine, Skewes, Karla Yareli Hernandez, Jimenez, Cristian, Licona‐meníndez, Roque Delfino, Montiel, Guillermo, Navarrete‐peón, Alberto, Ortega, Shannat, Lechuga, Fernanda Romero, Roque, Oscar, Sevilla, Fernando, González‐lópez, Rogelio, Núñez‐gonzález, Roberto ángel, Ortega‐jiménez, José Antonio, Alvarado, Antonio, Orendain, Alfonso Alvarez Manilla, Pesquera, José Alberto Atristain, Frutos, Diego, Garcia, Felipe, León, Juan Antonio González, Guzman, Marlin, Herappe, Dorihela, Miranda, Jesús Giovanni Inzunza, Botello, Miguel Angel Jimenez, Lerma, Ricardo, Pedraza, Fabián Hilario Mendoza, Castillo, Monica Noguez, Resendiz, Jose Anatolio, García, Oscar Alejandro Sánchez, Rios, Laura Elena Fernandez, Frigerio, Pamela, Garcia, Iset, Frías, Gloria Isela Mendoza, Moreno, Emmanuel, Quiroga, Raquel, Mendoza, Alejandra Anzures, Hinojosa, Arantza Govela, Izaguirre, Aldo, Miguelena, Luis Hdez, Vazquez, Jose Manuel Luna, Rodriguez, Indalecio Barcelata, Mange, Raul Ramos, Utrera, Carlos Reyes, Saenz, David Zarate, Gonzalez, Miguel Angel Zavala, González, Francisco Andrade, Cortes, Ludivina, Roman, David, Sanchez, Aaron, Gurghiș, Radu, Rojnoveanu, Gheorghe, Vozian, Marin, Caraja, Petru, Croitor, Gheorghe, Mosneaga, Roman, Erdene, Sarnai, Ganbold, Lundeg, Orgoi, Sergelen, Orsoo, Soyombo, Sainbayar, Altanchimeg, Sandag, Erdene, Sanjaa, Burmaa, Benhamou, Rita Ait, El Azhari, Abdessamad, Ghita, Bennis, Lhassani, Sara, Louraoui, Sidi Mamoun, Rghioui, Mounir, Saaf, Sarra, Gadouali, Taha, Gouazar, Iltimass, Korch, Moniba, Letrache, Ahmed, Louari, Amina, Zamame, Anas, Ousouss, Samia, Zekhnini, Meryem, Abderrazaq, Hafni, Abichou, Wijden, Ahlaou, Hamza, Baicha, Amal, Baroudi, Salma, Chaoui, Ghita, El Azzazi, Hind, El Masaoudi, Saja, Hassoun, Chiraz, Moujtahid, Hajar, Riyahi, Anas, Zaim, Ouijdane, Aji, Narjiss, Ammouze, Imane, Arkha, Yasser, Bechri, Hajar, Belabbes, Meryem Benchekroun, Benslimane, Zaineb, Boualila, Lina, Bouanani, Othmane, El Ouahabi, Abdessamad, Hossyni, Leila Essakalli, Malik, Boulaadas, Oudrhiri, Mohammed Yassaad, Sefrioui, Taha Ismail, Tagmouti, Adam, Bensghir, Mustapha, Elkoundi, Abdelghafour, Belarabi, Othman, Belkhadir, Zakaria Houssaïn, Benkabbou, Amine, Boutayeb, Saber, El Ahmadi, Brahim, El Bouazizi, Yassine, Ghannam, Abdelilah, Kabbaj, Taha, Majbar, Anass Mohammed, Mohsine, Raouf, Souadka, Amine, Kone, Badra Aliou, Ndatewapo, Fillipus, Njuki, Peter Ngungi, Abrahams, Jenevive, Jeketera, Clara, Yeboah, Kwasi, Abebrese, John Tabiri, Mureko, Alfred, Quayson, Francis William, Shikongo, Justina, Bhusal, Subarna, Dwa, Yam, Joshi, Ashoo, Berkeveld, Eva, Bloemers, Frank, Borgstein, Alexander, Gisbertz, Suzanne, Mikdad, Sarah, Berge Henegouwen, Mark, Bakx, Roel, Besselink, Marc, Lemmers, Daniel HL, Roelofs, Anne‐jasmin, Amstel, Paul, Helsdingen, Claire, Smeele, Ludi, Harlaar, Niels, Jonker, Frederik, Burg, Sjirk, Oostendorp, Justin Y., Ombashi, Saranda, Voort, Tim, Geldorp, Martijn, Posma‐bouman, Lisanne, Boer, Hans Donald, Olieman, Annette, Smid‐nanninga, Henriette, De Vries, Jean‐Paul P. M., Hogenbirk, Rianne, Derksen, Tyche, Franken, Josephine, Oosterling, Steven, Nolte, Peter, List, Jelle, Alwayn, Ian, Bijlstra, Okker, Braat, Andries, Bulder, Ruth, Kok, Michèle, Faber, Robin, Goudsmit, Ben, Hamming, Jaap, Mieog, Sven, Vahrmeijer, Alexander, Leemkolk, Fenna E. M., Vorst, Joost, Schaik, Jan, Verhagen, Merel, Albers, Kim, Gawria, Larsa, Van Goor, Harry, Warle, Michiel, Ginhoven, Tessa M., Viëtor, Charlotte, Boerma, Evert‐jan, Lallitsch, Lara, Schweitzer, Donald, Leclercq, Wouter, Sijmons, Julie, Vancoillie, Peter‐jan, Konsten, Joop, Heinsbergen, Maarten, Dekker, Nicole, Boer, Frank, Dimech, Julian, Djamali, Kaveh, Fowler, Carolyn, Ghamri, Naji, Houston, Helen, Joseph, Reece, Kantroo, Astha, Kwun, Jin, Lie, Samuel, Lightfoot, Nicholas, Maccormick, Andrew, Olliff, Sue, Trilokekar, Natasha, Wood, Daniel, Ekanayaka, Aruna, Furkert, Chris, Nanayakkara, Asanga, Panesar, Divyansh, Waddell, Oliver, Bidois, Lauren, Clifford, Zoe, Frizelle, Frank, Glyn, Tamara, Lim, Eric, Lyons, Oliver, Mclauchlan, Jared, Nicholas, Ella, O’Grady, Michael, Roake, Justin, Singh, Harsh, Ailabouni, Ramez, Rietveld, John, Alqassab, Mohammed, Amer, Mostafa, Chan, Annie, Egbuji, John, Fullarton, Mairi, Haddow, James, Hawkins, Robyn, Vui Teck, Lu, Oliver, Thomas, Saw, Kai Sheng, Sugunesegran, Ramanen, Wilkins, James, Woodfield, Esther, Baker, Joseph, Cama, Jitoko, Field, Xavier, Fulivai, Alamea, Hossain, Ruhella, Kelly, Ben, Jasen, Ly, Mckelvie, James, Meiyappan, Vivek, Cindy Xin Yi, Ou, Singh, Vidit, Hedley, Alex, Temara, Hinerangi, Aitken, Jake, Frunt, Brytt, Boys, Max Hardie, Lakshman, Prashant, Pinfold, Esther, Cowan, Sarah, Henderson, Nigel, Leary, Jessica, Castle, Cameron, Gaston, Matt, Haimona, Maira, Jury, Steffanie, Lahood, Zoe, Lim, Matthew, Macintyre, Dillon, Mak, Josephine, Neal, Annelise, Shelker, William, Weeratunga, George, Ferguson, Liam, Harmston, Christopher, Heaven, Chelsea L, Watt, Imogen, Cahill, Henry Witcomb, Abdurrazzaaq, Abdussemee, Abdussalam, Hameedat Opeyemi, Adebanjo, Ademola, Ahmed, Aminat Olayinka, Borokinni, Opeyemi Busayo, Fasiku, Olushola Kayode, Gwaram, Usman, Okoye, Onyedika, Olaomi, Oluwole, Adeyeye, Ademola, Enoch, Elizabeth, Fayose, Samuel, Kayode‐nissi, Victor, Kadiri, Innih, Oduah, Stella, Abdull, Mohammed, Abdullahi, Mohammed Kabir, Kwankiyel, Auwal Babayo, Umar, Shahir Bello, Hassan, Sulaiman, Ja’Afar, Abubakar Bappah, Ja’Afaru, Umma Hani, Kadas, Saidu, Liman, Haruna, Makama, Baje, Mohammad, Aminu Mohammad, Kirfi, Abdullahi Musa, Oyediji, Funmilayo, Mohammed, Husseini Yakubu, Akpoghor, Oghenevwegba, Arekhandia, Alexander, Dawodu, Oseyi, Edetanlen, Ekaniyere, Efobi, Chizoba, Egbor, Esezobor, Enaruna, Nosakhare, Ezeanochie, Michael, Ezenwa, Ekene, Ijekeye, Ferdinand, Imumoren, Joe, Iribhogbe, Oseihie, Irowa, Omorodion, Momoh, Moses, Nwashilli, Nnamdi, Obahiagbon, Osarobo, Obuekwe, Ozoemene, Odai, Emeka Danielson, Odigie, Vincent, Odutola, Oluwatomi, Okhakhu, Amina, Okugbo, Stanley, Oni, Samson, Onyeagwara, Ngozi, Oseghale, Eustace, Osemwegie, Osarenkhoe, Osho, Philip, Ugwi, Veronica, Uwagboe, Charles, Yusuf, Sofiat, Abiodun, Adekunle, Akinloa, Olufemi, Shodipo, Moses, Abdullahi, Alhassan, Lawal, Ishak, Echieh, Chidiebere Peter, Nwagboso, Chimaobi, Udoh, Ubong, Akanni, Bolaji, Anyimba, Solomon, Chukwu, Isaac, Ezomike, Uchechukwu, Gold, Ikponmwosa, Nnabugwu, Ikenna, Nwafor, Ikechukwu, Okolie, Louis, Okoro, Kelechukwu, Okwara, Blasius, Onyemaechi, Ndubuisi, Abdulsalam, Khalifa, Arogundade, Abayomi, Kura, Mohammed, Nwosu, David, Abdullahi, Habiba, Agida, Eyaofun, Aisuodionoe‐shadrach, Oseremen, Ajibola, Hafees, Akaba, Godwin, Ale, Omolabake, Atim, Terkaa, Emeka, Malachy Ayogu, Benard, Adeka, Buba, Amina, Chinda, John, Edino, Stephen, Eniola, Sefiu, Garba, Stephen, Isah, Aliyu, Isah, Dennis Anthony, Joshua, Zaman, Mbajiekwe, Ndubuisi, Mshelbwala, Philip, Muhammad, Rafat, Offiong, Richard, Olute, Anne, Osagie, Olabisi, Ogolekwu, Idoko Pius, Sulaiman, Bilal, Suleiman, Salisu, Umar, Aminu, Abayomi, Olukayode, Abdus‐salam, Rukiyat, Adebayo, Sikiru A., Adeleye, Amos, Ademola, Samuel, Afuwape, Oludolapo, Ajao, Akinlabi, Akinsola, Sanusi, Aladelusi, Timothy, Ayandipo, Omobolaji, Baiyewu, Lateef Ayodele, Balogun, Mosimabale, Daodu, Israel, Egbuchulem, Ifeanyichukwu Kelvin, Elemile, Peter, Ezeme, Constantine, Fasunla, Ayotunde James, Gbolahan, Olalere, Iwuagwu, Ifeanyi, Michael, Afieharo, Morhason‐bello, Jemiludeen, Nwaorgu, Onyekwere, Obadan, Izegaegbe, Odeyemi, Olubunmi, Ogundoyin, Omowonuola, Ogundoyin, Olakayode, Ogunkeyede, Segun Ayodeji, Ogunrewo, Tolulope, Okere, Oghenekevwe, Oladejo, Titilola, Oladiran, Ajibola, Olagunju, Naomi, Olaoye, Ifedolapo, Olawoye, Olayinka, Olulana, Dare, Olusanya, Adeola, Omigbodun, Akinyinka, Onakoya, Paul, Orji, Mathias, Oyelakin, Oyeleye, Oyewole, Olugboyega, Sule, Samuel, Takure, Augustine O, Ugwu, Ebere, Afolabi, Bosede, Ajayi, Peter, Akinajo, Opeyemi, Alakaloko, Felix, Atoyebi, Oluwole, Belie, Orimisan, Bode, Chris, George, Ihediwa Chibuike, Elebute, Olumide, Ezenwankwo, Francis, Fatuga, Adedeji, Ladipo‐ajayi, Oluwaseun, Makanjuola, Ayomide, Makwe, Christian, Mofikoya, Bolaji, Ohazurike, Ephraim, Ojewola, Rufus Wale, Okunade, Kehinde, Okunowo, Adeyemi, Olajide, Thomas Olagboyega, Oni, Oluwafemi, Tijani, Kehinde, Ugburo, Andrew, Ugwu, Aloy Okechukwu, Abiola, Paul, Abiyere, Henry, Adebara, Idowu, Adeniyi, Adebayo, Adeyemo, Olabisi, Ariyibi, Abimbola, Babalola, Olakunle, Bakare, Adewumi, Banjo, Oluseyi, Egharevba, Peter, Obateru, John, Ojo, Owolabi, Olajide, Adewale, Oluwafemi, Fatudimu, Oyeleye, Oluwole, Salawu, Adedayo, Babatunde, Bakare Tajudeen Ishola, Abdulsalam, Moruf, Adelaja, Aderinsola, Adeniran, Abimbola, Ajai, Olalekan, Atobatele, Kazeem, Ayodele, Olabamidele, Bello, Funmi, Faboya, Omolara, Idowu, Olufemi, Idowu, Jeuel, Mustapha, Muntaqa, Omisanjo, Olufunmilade, Osuoji, Roland, Vitowanu, Julius, Abe, Anthonia, Aderounmu, Adewale, Adesunkanmi, Abdulhafiz, Ajekwu, Temitope, Ajekwu, Samuel, Ajiboye, Olalekan, Aderogba, Adeleke Akeem, Alatise, Olusegun Isaac, Babatunde, Mustapha, Balogun, Simon, Ijarotimi, Adebimpe, Lawal, Adedayo, Ojo, Olugbenga, Olasehinde, Olalekan, Olugbami, Adebayo, Ubom, Akaninyene Eseme, Agbaje, Ademola, Mohammed, Tajudeen, Adeniran, Abiodun, Adesola, Muideen, Afolabi, Abdulrahman O., Aremu, Isiaka, Ayinmode, Iyehunwa, Bello, Jibril, Ezeoke, Grace, Gwadabe, Sadiya, Ibraheem, Gbadebo, Ibrahim, Saidu, Ijaiya, Munir’Deen, Nasir, Abdulrasheed, Odeyemi, Peter Olalekan, Ogunade, Olukayode, Olabinjo, Afusat, Olatoke, Samuel Adegboyega, Olowogbayi, Tope, Onjefu, Stephen, Popoola, Ademola, Raji, Hadijat Olaide, Salawu, Nasiru, Salawu, Hafeez, Sayomi, Tolulope Olayinka, Segun‐busari, Segun, Uche‐okonkwo, Kenechukwu, Abiola, Olajide, Anipole, Olalekan, Ogunlaja, Olumuyiwa, Adesina, Oluwaseyi, Alayande, Barnabas, Ebenezer, John, Enwerem, Kenneth, Isichei, Christian, Isichei, Mercy, Luku, Pwaluke, Omiragi, Paul, Onyeji, John, Adze, Joel, Aghadi, Ifeanyi, Auta, Akawu, Duniya, Sharon, Gyuro, Joseph, Lawal, Jamila, Makama, Jerry Godfrey, Mohammed, Garba, Mohammed‐durosinlorun, Amina, Salisu, Kabiru, Taingson, Matthew, Yusuf, Nuhu, Amos, Happy, Daniel, James, Takai, Idris Usman, Abdullahi, Lawal, Abdullahi, Sani, Abdulrahman, Mamuda, Abubakar, Mohammed Kabir, Adikaibe, Valentine, Ahmad, Misbahu, Ahmad, Jameel Ismail, Aji, Sani Ali, Aliyu, Mohammed Salele, Danagundi, Maryam Babba, Bako, Yusuf Halidu, Bello‐muhammad, Nafisatu, Garzali, Ibrahim Umar, Hasheem, Muhammad Ghazali, Hassan, Ismail, Hassan, Sadiq, Usman, Mustapha Ibrahim, Ismail, Nasiru, Jibril, Yasir Nuhu, Kurawa, Musbahu, Magashi, Mahmoud Kawu, Martins, Bardi, Bello, Usman Mohammed, Muhammad, Saminu, Muhammad, Abubakar Bala, Muhammad, Shamsuddeen, Daneji, Sulaiman Muhammad, Mukhtar, Ibrahim Aliyu, Adamu, Kabir Musa, Nwachukwu, Callistus, Omeje, Uchenna Kelvin, Orji, Ifeanyi James, Sheshe, Abdurrahman Abba, Suleiman, Ibrahim, Yunusa, Sani Abdullahi, Maryam, A, Abubakar, Kabiru Bello, Habib, Saudat Garba, Mahmood, Farrukh, Alabi, Ibrahim Abolaji, Arojuraye, Soliudeen, Salihu, Mohammed, Alade, Samuel, Kumolalo, Felix, Mogbo, Chiedozie, Adebayo, Olaolu, Ige, Oluwasuyi, Jones, Gbenga, Odunafolabi, Tunde, Olubayo, Oluniyi Oyetunde, Akani, Chris, Alasia, Datonye, Alegbeleye, Justina Omoikhefe, Aria, Oti Nimi, Awopeju, Abimbola, Edonkumoh, Kemebradikumo, Ekeke, Onyeanunam, Fyneface‐ogan, Sotonye, John, Celestine, Kasso, Terhemen, Korubo, Inye, Mato, Christie, Ogu, Rosemary, Okpani, Charles, Okpani, Anthony, Onwuagha, Ijeoma, Oppah, Ijeoma, Oputa, Victory, Oranu, Emmanuel, Orazulike, Ngozi, Otokwala, Job, Ugboma, Henry A. A, Ajayi, Adekunle, Ogundele, Ibukunolu, Salami, Babatunde, Ajagha, Okeoghene, Ali, Yakubu, Awaisu, Mudi, Daniyan, Muhammad, Fidelis, Lovely, Nwabuoku, Stanley Emeka, Ogunsua, Oluseyi, Oyelowo, Nasir, Sholadoye, Tunde T., Yakubu, Alfa, Rendevski, Vladimir, Shuntov, Blagoj, Shuntov, Natalija Cokleska, Georgieva, Gordana, Jovanoski, Tomislav, Jovanovska, Katerina, Nikolovska, Bisera, Peev, Igor, Srbov, Blagoja, Trajkova, Andrijana, Trenchev, Viktor, Dohcev, Sasho, Janchulev, Josif, Saidi, Skender, Stankov, Oliver, Trifunovski, Aleksandar, Draz, Najib Abu, Al Ajmi, Khalil, Al Ajmi, Ghadeer, Al Amri, Ayman, Al Badaai, Ghalib, Al Balushi, Nawf, Al Bassam, Wameedh, Al Farsi, Maather, Al Ghafri, Wadha, Al Ghafry, Alaa, Al HOSNI, Mohammed, Al Kalbani, Moza, Al Kalbani, Maha, Al Kharusi, Lamya, Al Kharusi, Safiya, Al Mutani, Mohammed, Al Qadhi, Hani, Al Raisi, Amani, Al Riyami, Nihal, Al Sabti, Hilal, Al Shaibi, Maha, Al‐abri, Rashid, Al‐mujaini, Abdullah, Al‐rashdi, Aya, Alajmi, Suha, Albadi, Zamzam, Albusaidi, Hanadi, Alhadeethi, Ahmed, Aljabri, Noor, Alkazrooni, Muhannad, Alkharousi, Nadiya, Alkharusi, Al‐salt, Alkiyumi, Khadija, Almaharbi, Noof, Alsaadi, Sabaa, Alsharji, Marwa, Alsharqi, ALi Hamed, Alshehhi, Fatma, Alsulaimani, Thuwaiba, Alward, Mustafa, Alwashahi, Mohammed, Alyafii, Hussain, Alzadjali, Adil, Basi, Tayseer, Dalmar, Khadija, Dawud, Bashar, Gargouri, Mohamed Mourad, Kariyattil, Rajeev, Kenawy, Ahmed Omer, Kochummen, Koshy, Kolethekkat, Arif, Pillai, Mahesh Krishna, Sureshkannan, Ks, Laghari, Farman Ali, Manjunatha, Attibele Palaksha, Mathew, Joseph Kunju, Muzaffar, Rahil, Nair, Asha, Naiya, Hafsa Ismail Ibrahim, Nazar, Zuhail, Pillai, Silja, Rahim, Ferdous, Rahman, Khalid, Sheik, Shahila, Siddiqi, Mohammad Salman, Stephen, Edwin, Younas, Shahzad, Fatima, Mishal, Javed, Ayesha, Khan, Muhammad Ahsan, Shakir, Fatima Tuz Zahra, Siddiqui, Riaz Hussain, Syed, Danish, Rehman, Ishtiaq Ur, Warraich, Shahrukh, Amir, Mohammed, Asghar, Saleha Yurf, Bangash, Ali Haider, Latif, Sehrish, Naqvi, Wajih, Abdullah, Muhammad Tariq, Abdullah, Saleha, Ahmed, Arooj, Ahsan, Muhammad Fahim Ahsan, Akhtar, Fahad, Ali, Sana, Ansar, Mehwish, Aqib, Muhammad, Arslan, Muhammad, Ashraf, Sumaira, Ayubi, Azaz, Azam, Tayyab, Bhatti, Hamza, Huda, Shahab, Irshad, Abeer, Ishaque, Nazia, Khaliq, Tanwir, Khan, Farheen, Khan, Mumtaz Ahmad Khan, Mahmood, Namrah, Malik, Ali Raza, Malik, Tahir, Malik, Komail, Mehmood, Manzer, Mustafa, Fatima, Noor, Fazal, Nubair, Sarwar, Rashid, Isbah, Saeed, Waqar, Sajid, Hannan, Shah, Sajid, Shami, Ali, Siraj, Minhaj Us Siraj, Tareen, Mariam, Haq, M Burhan Ul, Abbas, Manzar, Zaidi, Syeda Maria Ahmad, Ahmed, Iffat, Ahmed, Shahnoor, Ahsan, Kunwar Armash, Akhtar, Munazza, Akhund, Ramsha, Manji, Adil Al‐Karim, Arshad, Hajra, Awan, Muhammad Ozair, Aziz, Humaira, Bhutto, Shameen, Aamir, Faiqa Binte, Biyabani, Syed Raziuddin, Chishti, Uzma, Chundrigar, Mohsin, Ghaloo, Shayan Khalid, Haroon, Waqqas, Hashmi, Shiraz, Hassan, Murtuza, Inam, Hina, Kassam, Nausheen, Kazmi, Abbas, Khan, Majid, Khan, Muhammad Osama, Kumari, Sameeta, Malik, Muhammad Jehangir, Mansoor, Maheen, Martins, Russell Seth, Mubarik, Areeba, Munir, Muhammad Musaab, Musharraf, Muhammad Bazil, Naz, Falak, Noordin, Shahryar, Pervaiz, Arsalan, Qamar, Javeria Bilal, Rahman, M Fazlur, Rani, Pallavi, Rasheed, Yasir, Sadia, Haleema, Saeed, Marwah, Safri, Mohammad, Salim, Shaharyar, Sattar, Abida K., Shamim, Shahzad, Sherwani, Maryam, Siddiqui, Muhammad Ahsan Iqbal, Sidhwa, Astad, Tariq, Javeria, Tejani, Isbaah, Waqar, Usama, Zahid, Fahad, Jamal, Abid, Ghufran, Muhammad Ali, Memon, Amjad Siraj, Saeed, Summaya, Samo, Khursheed Ahmed, Aswani, Manisha, Manzoor, Shahneela, Muhammad, Shoaib, Arshad, Muhammad, Hussain, Syeda Namayah Fatima, Moin, Inshrah, Najjad, Muhammad Kazim Rahim, Nasir, Manal, Sohail, Osama Bin, Mangi, Ali, Markhand, Naveed, Mushtaq, Hassan, Zia, Kashif, Ahmed, Hassaan, Ahmed, Nasir, Qureshi, Talha Ahmed, Shaikh, Shafqat Ali, Anwer, Rabia, Arshad, Owais, Batool, Sehrish, Chatni, Muhammad, Chundrigar, Tariq, Dojki, Samina Saleem, Elahi, Minahil, Farooqui, Bakhtawar, Ghouri, Amna, Hassan, Nabeel, Hussain, Zainab, Hussaini, Null, Iftikhar, Fizza, Iqbal, Faizan, Javed, Anum, Javed, Dania, Kamal, Wajahat, Khan, Shifa, Mughal, Zeeshan Uddin, Murtaza, Ghulam, Nadeem, Areeba, Nasir, Areeba, Nayyer, Fatima, Nisa, Kanwal, Rauf, Yaseen, Haroon, Umer Saeed, Saleem, Shah Masabat, Seriwala, Haseeb, Shah, Aaqil, Siddiqui, Safia, Tanveer, Asher Tanweer, Tariq, Nida, Zaman, Junaid, Zamir, Mehroz, Anjum, Muhammad Ayyub, Afzal, Ameer, Ahmed, Ehsan, Ahmed, Jawad, Riaz, Shujat Ahmed, Akbar, Ali, Akbar, Bilal, Ali, Maria, Ali, Imran Ali, Ali, Abrar Ashraf, Ali, Ghazanfar, Altaf, Zahra, Ammar, Ahmed Siddique, Arif, Hafiz Muhammad Arif, Aslam, Imran, Bashir, Muhammad Mustehsan, Farooq, Usman, Farooq, Muhammad, Gondal, Khalid Masood, Iqbal, Muhammad Javed, Iqbal, Zafar, Ismail, Fahad, Jameel, Muhammad Khurram, Janjua, Muhammad Haris, Janjua, Azwa, Joshi, Prabesh, Khadam, Mamoona, Khan, Romaisa, Khawaja, Muhammad Asadullah, Manzoor, Sobia, Mohsin, Muhammad, Mumtaz, Khizra, Musaab, Muhammad, Naqi, Syed Asghar, Naumeri, Fatima, Nazir, Umer, Noureen, Sadaf, Rafi, Yaseen, Raza, Ali, Rijal, Sushil, Saleem, Irfan, Shah, Hafiz Syed Zaigham Ali, Sharif, Muhammad, Shaukat, Ayesha, Siddique, Usman, Sikandar, Hafiz Saqib, Sohail, Mohammad, Zahara, Fatima Tu, Usman, Yasmeen, Zaman, Balakh Sher, Zeb, Misbah, Afzal, Muhammad Farooq, Ahmad, Fateen, Ahmed, Waqas, Akram, Shahzad, Alam, Azhar, Ali, Danish, Ali, Ahsan, Alvi, Ammar Tariq, Asif, Suleman Asif, Aslam, Madiha, Daood, Muhammad Daood, Jawad, Muhammad, Kathia, Usama Muhammad, Khalid, Ismaeel, Khan, Anwar, Khurshid, Zain, Noman, Hamza, Raza, Ahsan, Taha, Hassan, Zubair, Muhammad, Maria, Noor Ul Huda, Janjua, DrAtif A, Ahmad, Qamar Ashfaq, Ahmad, Sheraz, Ali, Imran, Amin, Sana, Anjum, Momina, Asjad, Muhammad, Aslam, Aatif, Ayyaz, Mahmood, Bajwa, Luqman Ali, Bakhtiar, Akkasha, Bashir, Alia, Batool, Fizza, Bhatti, Samiullah, Butt, Roshan, Butt, Usman, Changazi, Shabbar Hussain, Cheema, Omer Iqbal, Chishti, Muhammad Haris, Haq, Bushra, Hashmi, Ali, Hassan, Muhammad, Hassan, Usman, Hayat, Khizar, Iqbal, Javaid, Iqbal, Ayesha, Ishaq, Amna, Javed, Sundas, Javed, Hina, Javed, Aymen, Kashif, Muhammad, Khalid, Muhammad Saud, Khan, Wasim Hayat, Khan, Rohma, Khan, Fatima, Latif, Usman, Mahmood, Arif, Majeed, Faizan, Malik, Kiren, Masood, Rumaisa, Munawwar, Fasiha, Mushtaq, Asma, Nabi, Muhammad Shoaib, Nasir, Ahmad, Naureen, Shazia, Noreen, Zahida, Qadir, Muhammad Ghulam Qadir, Raana, Gul e Raana, Rashid, Madeeha, Rehman, Abdul, Riaz, Sidra, Saboor, Arfa, Sadiq, Muhammad Hamza, Saeed, Komal, Saleem, Humaira, Sarfraz, Kiran, Shafiq, Zahid, Shafqat, Aymen, Shaukat, Hassan, Sher, Fateh, Sohail, Rubina, Suhail, Amina, Muhammad, Bilal Syed, Umair, Usama, Umar, Muhammad, Usama, Muhammad, Usman, Natasha, Waheed, Kalsoom, Farooka, Muhammad Waris, Wasim, Shafqat, Wasim, Tayyiba, Yasin, Fahad, Zafar, Zain, Zaka, Sabahat, Zaman, Salma Zaman, Azad, Junaid, Fatima, Zareen, Anwar, Muhammad Imran, Naseer, Muhammad Ahmed, Shah, Muhammad Taimoor, Ali, Ammar, Aslam, Muhammad, Aziz, Muhammad Usama, Gohar, Farhan, Humayoun, Waseem, Khan, Hassan, Naeem, Shiza, Tahir, Warda, Alvi, Kashif, Mehmood, Maria, Ali, Muhammad, Shahzad, Aniqa, Sher, Muhammad, Murtaza, Null, Siddique, Hijab, Anjum, Waleed, Ahmad, Manzoor, Alam, Muhammad, Faizi, Fouzia, Faridoon, Shehla, Hussain, Musarrat, Iftikhar, Muhammad, Jan, Yousaf, Kalim, Muhammad, Raza, Tilal Ahmed, Shah, Farrukh Ozair, Shah, Muhammad, Tahir, Imran, Khan, Hamza, Naeem, Muhammad, Ahmad, Shabir, Ahmed, Haseeb, Akbar, Hazrat Akbar, Akhtar, Muhammad Shaheer, Ali, Noman, Ali, Mehboob, Ali, Sadaf, Ali, Irfan, Amin, Hasbi Allah, Amin, Shehzadi, Ayub, Bakhtawar, Basir, Muhammad, Faraz, Ahmad, Farsi, Muhammad Salman, Gul, Ambrin, Gul, Hina, Gul, Ayaz, Gul, Sana, Haider, Sajjad L, Ikramullah, Syed Ikramullah, Jan, Kashif, Khalid, Muhammad, 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(INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), GlobalSurg Collaborative, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, AGEM - Endocrinology, metabolism and nutrition, ARD - Amsterdam Reproduction and Development, Paediatrics, Tytgat Institute for Liver and Intestinal Research, Nepogodiev, D., Simoes, J. 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A., Workneh, W., Genetu, S., Mebratu, E., Chanyalew, L., Deresse, T., Girma, A., Seid, M., Shimelash, D., Shitaw, A., Ayalew, T., Diress, T., Kassahun, B., Kassaye, B., Mulugeta, E., Tesfaw, G., Yimenu, B., Benecha, S., Aman, M., Mekete, A., Tesemma, A., Mohammed, A. A., Abdullahi, Y. Y., Adem, E., Ahmedin, M., Assefa, Y., Ayde, F., Berhe, A., Gebremeskel, Z., Siyoum, E. G., Teresa, S., Wude, Z., Yemer, F., Yohannes, D., Zeleke, E., Zerihun, G., Degefe, D. W., Derilo, H. T., Eliyas, N., Bayissa, F., Deressa, Y., Gemechu, L., Gurmu, T., Kasaye, A., Melese, L., Muleta, L., Mulugeta, G., Taye, S., Teshome, A., Tesso, B., Gebrekirstos, G., Haile, M., Kassa, H., Saddik, M., Mengist, A., Heikkinen, J., Helminen, O., Huhta, H., Kotkavaara, T., Mosorin, M. -A., Pitkanen, J., Qian, C., Sinikumpu, J., Sova, H., Tastula, M., Virta, V. 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M., Salle, H., Taibi, A., Tricard, J., Usseglio, J., Chopinet, S., Gregoire, E., Delpont, M., Blanchard, C., Crenn, V., de Vergie, S., Denis, W., Fragnaud, H., Regenet, N., Rigaud, J., Varenne, Y., Anract, P., Barat, M., Biau, D., Dautry, R., Dohan, A., Idier, L., Lang, E., Thouny, C., Tzedakis, S., Audenet, F., Cazelles, A., Chamouni, A., Karoui, M., Mejean, A., Clermidi, P., Langlais, T., Leonelli, L., Maisonneuve, E., Nicolas, B., Perrot, O., Prost, D., Thomin, A., Thouement, T., Athiel, Y., Berry, R., Boddaert, G., Bonnet, S., Cathala, N., Conso, C., Denet, C., Laforest, A., Levy-Zauberman, Y., Macek, P., Mombet, A., Ollat, D., Scamporlino, A., Zadegan, F., Amine, C. A., Baratte, B., Chartier-Kastler, E., Chereau, N., Colas, P. -A., Duquesne, I., Genser, L., Petit, G. 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A., Asaph, E., Baruwa, E., Hofman, G., Machemedze, S., Idiata, M. M., Muhemi, R., Ndizeye, O., Nkunzimana, E., O'Connor, J., O'Connor, Z., Tchoba, S., Boumas, N., Devidze, G., Pisarevi, G., Baumgarten, S., Grusser, L., Holzle, F., Kowark, P., Kowark, A., Rossaint, R., Schafer, B., Wallqvist, J., Winnand, P., Ziemann, S., Anthuber, M., Broecheler, T., Edlinger, F., Gosslau, Y., Hyhlik-Duerr, A., Maksymiw, F., Shiban, E., Sommer, F., Sommer, B., Zerwes, S., Beyer, K., Lauscher, J. C., Lee, L. D., Loch, F. N., Schineis, C., Aghalarov, I., Belyaev, O., Braumann, C., Enste, A., Fahlbusch, T., Herzog, T., Horn, J., Jedanowski, J., Knipschild, J., Luu, A. M., Mohan, P. V., Siemen, L., Slobodkin, I., Strotmann, J. J., Uhl, W., Wolf, K., Coburn, M., Egger, E., Eichhorn, K., Enderes, J., Far, F., Franzen, A., Guresir, E., Hadjiathanasiou, A., Kalff, J. C., Kohistani, Z., Manekeller, S., Mustea, A., Probst, C., Randau, T., Recker, F., Schuss, P., Strassberger-Nerschbach, N., Strieth, S., Treede, H., van Beekum, C. J., Vatter, H., Velten, M., Vilz, T. O., Wirtz, D., Wittmann, M., Behr, M., Bulian, D. R., Marche, B., Moczko, T., Otchwemah, R., Schulz, S. -A., Thomaidis, P., Bruns, C., Cursiefen, C., Domrose, C., Fuchs, H., Heindl, L. M., Mallmann, M. R., Mallmann, C., Ratiu, D. A., Canzler, U., Distler, M., Korn, S., Meisel, C., Meusel, M., Petzold, A., Praetorius, C., von Renesse, J., Weitz, J., Wimberger, P., Alkhanji, N., Fung, S., Jaber, K., Knoefel, W. T., Vay, C., Clonda, O., Cottin, T., Juodiene, E., Juodis, D., Petrovic, B., Solodarenko, O., Binder, J., Grutzmann, R., Hackner, D., Junker, S., Arsalan, M., Banek, S., Chun, F., Faqar-Uz-Zaman, S. F., Keese, D., Kluth, L., Rolle, U., Van Linden, A., Walther, T., Bayer, J., Beck, J., Fung, C., Kraus, L. M., Leiber, C., Neidert, N., Sandkamp, R., Schnell, O., Schulte, A., Strahle, J., Jarmusch, S., Novotny, H. F. G., Becker, J., Fulghum, C., Gonschor, B., Herbolzheimer, M., Nicolaiciuc, S., Trulson, A., Vogelsang, H., Zimmermann, B., Akbari, A. A., Boening, A., Edinger, F., Hecker, M., Knitschke, M., Koch, C., Reichert, M., Schmidt, G., Schneck, E., Uhl, E., Nobrega, S. F., Kauffmann, P., Miller, C., Nemeth, M., Sievers, D., Kisser, U., Kleeff, J., Klose, J., Lorenz, K., Papendick, N., Plontke, S., Seiwerth, I., Steer, S., Thomssen, C., Ukkat, J., Dumpies, C. W., Gessner, M., Hanke, J., Klauke, F., Leuschner, S., Mendel, T., Muller, K., Schmidt, B., Schreiter, V., Stosberg, P., Vinz, F., Herbig, B., Sander, J., Schulte, T. M., Betz, C. S., Bewarder, J., Bier, J., Bottcher, A., Burg, S., Busch, C. -J., Bussmann, L., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Konig, D., Kopke, L. -G., Moeckelmann, N., Praetorius, M., Priemel, M., Stadlhofer, R., Stangenberg, M., Uzunoglu, F. 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V., Diamantis, A., Fichter, A., Grill, F., Heck, M., Jira, D., Kallmayer, M., Koll, F., Luhne, S., Meyer, B., Patachia, R., Pergolini, I., Safi, S., Schaffer, C., Schirren, M., Wegmann, H., Wirth, M., Zhu, Z., Aghamaliyev, U., Almaghrabi, M., Bocker, W., Bruder, J., Frank, K., Herterich, V., Huber, V., Ilmer, M., Kammerlander, C., Neuerburg, C., von Ehrlich-Treuenstatt, V. H., Werner, J., Borner, N., Fegg, F., Hartmann, D., Ladurner, R., Liokatis, P., Patzer, K., Schlager, J. G., Smolka, W., Zimmermann, P., Hatz, R., Steinhart, D., Glowalla, C., Schneidmueller, D., Henkel, K. W., Steiner, M., Holz, K., Knorr, C., Kuehlmann, B., Oikonomou, K., Prantl, L., Flurschutz, R., Honarpisheh, H., Kroger, M., Lepiorz, D., Luths, C., Niemeier, A., Sras, Y., Strate, T., Winter, T., Freiman, T., Gessler, F., Won, S. -Y., Widyaningsih, R., Hoffmann, S., Schafer, R. C., Thiel, J. T., Bertolani, E., Steidle, C., Uberruck, L., Yurttas, C., Ziegler, P., Zimmermann, A., Bolenz, C., Dayan, D., Greve, J., Hoffmann, T. K., Janni, W., Lobig, N., Schochter, F., Vahl, J. M., Wezel, F., Greif, V., Schmidbauer, S., Marsch, I., Schneider, R., Boenicke, L., Degener, S., Dreger, N. M., Horstmeier, F. C., Kruschwitz, J., Rombach, A., Schmidt, N., Seiberth, R., Singh, J., Smit, M., von Rundstedt, F. -C., Zirngibl, H., Diessner, J., Friedrich, S., Germer, C. -T., Helmer, P., Herrmann, J., Kranke, P., Kubler, H., Lock, J., Lotz, C., Meffert, R., Meybohm, P., Muller, S., Notz, Q., Popp, M., Schlegel, N., Schlesinger, T., Schmid, B., Sitter, M., Steinisch, A., Treutlein, A., van den Berg, A., Wurmb, T. E., Agyeman-Duah, N. K., Appiah, E., Armah, R., Asare, C., Awere-Kyere, L., Daary, D., Gakpetor, D., Allah, S. M., Obbeng, A., Osei-Poku, D., Puozaa, D., Tackie, E., Adu-Aryee, N. A., Agboadoh, N., Asare, O., Bowan, A. B., Brown, G. D., Clegg-Lamptey, J. -N., Dedey, F., Dery, C., Fenu, B. S., Harrison, M. A., Kumassah, P., Kuuzie, E., Nsaful, J., Olayiwola, D. O., Smith, C., Banka, C., Hussey, R., Azize, D. A., Aniakwo, L. A., Adofo-Asamoah, Y., Agbeno, E. K., Agyapong, M. M., Agyen, T., Mensah, K. A., Alhassan, B. A. B., Amoako-Boateng, M., Appiah-Thompson, P., Gyimah, N. A. -M., Asante-Bremang, M., Asante-Asamani, A., Atawurah, H., Appiah, A. B., Baidoo, R. O., Baidoo, E. I., Boakye, B., Boateng, A., Dadoe, D., Dayie, M. S. C. -J. K., Debrah, S., Doku, K., Enti, E., Ken-Amoah, S., Koggoh, P., Kpangkpari, R., Maison, P., Mensah, S., Mensah, P., Mensah, T. A., Morna, M. T., Nimako-Mensah, J., Nkrumah, J., Nortey, M., Ofori, E. O., Opandoh, I. N. M., Osei-Tutu, E., Adae, J. O., Quansah, K., Quartson, E., Rahman, G. A., Walawah, D., Yigah, M., Yussif, S., Jiagge, N., Nachelleh, E., Acquaye, J., Agbedinu, K., Agyei, F., Agyemang-Prempeh, A., Amo-Antwi, K., Amoah, M., Amoah, G., Amoako, Y. A., Aning, D. 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T. -A., Grypiotis, I., Kiriakopoulos, N., Koliopoulos, G., Kyvelos, V., Micha, G., Papadopoulou, T., Balalis, D., Fradelos, E., Korkolis, D., Alexakis, N., Angelou, K., Haidopoulos, D., Prodromidou, A., Rodolakis, A., Thomakos, N., Psychogios, D., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Dimitra, P., Fragkoulidis, G., Gkiokas, G., Gklavas, A., Hadjizacharias, T., Karageorgou, D., Konstadoulakis, M., Kontopoulou, C., Massaras, D., Memos, N., Papaconstantinou, I., Politis, D., Polydorou, A., Stamatis, K., Theodosopoulos, T., Vezakis, A., Avgerinos, K., Katunin, J., Kechagias, A., Kelgiorgi, D., Kritikos, N., Pengerma, P., Bisdas, T., Ioannidis, A., Konstantinidis, M., Konstantinidou, S., Patelis, N., Antonopoulou, M. I., Deskou, E., Kalles, V., Manatakis, D. K., Stamos, N., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Frountzas, M., Kokoropoulos, P., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Vassiliu, P., Paraskevas, K. I., Bartziotas, D., Bouchagier, K., Galanis, I., Kalamatianos, T., Kapiris, S., Kolinioti, A., Mavrodimitraki, E., Metaxas, P., Nikova, A., Psarologos, M., Sotiropoulou, M., Stranjalis, G., Albanopoulos, K., Kondilis, P., Vrakopoulou, G. Z., Chrysovergis, A., Chrysovitsiotis, G., Giotakis, E., Kanellopoulou, V., Kyrodimos, E., Larentzakis, A., Pantos, P., Papanikolaou, V., Potamianos, S., Theodoropoulos, C., Triantafyllou, A., Triantafyllou, T., Georgousi, K., Panagiotou, P., Avramidis, E., Babis, G., Zafeiris, E., Antoniou, A., Bessias, N., Maras, D., Papas, T., Roditis, K., Tsagkos, I., Tsiantoula, P., Alexandrou, A., Baili, E., Charalabopoulos, A., Dimitroulis, D., Dorovinis, P., Garoufalia, Z., Kanavidis, P., Karavokyros, I., Karydakis, L., Kykalos, S., Kyros, E., Machairas, N., Mastoraki, A., Nikiteas, N., Papalampros, A., Schizas, D., Skotsimara, A., Stamopoulos, P., Syllaios, A., Terras, A., Tomara, N., Tsourouflis, G., Vagios, I., Zografos, C., Apostolou, K., Georgopoulos, N., Antoniou, T., Antzaka, C., Falara, A., Fragoulis, S., Ftikos, P., Matsouka, F., Perreas, K., Rellia, P., Samara, E., Smirli, A., Tasouli, A., Thanopoulos, A., Chalkias, P. L., Dedemadi, G., Mourmouris, P., Skolarikos, A., Theochari, N., Tzelves, L., Gaitanakis, S., Milas, T., Theodorakis, E., Karona, P., Kastanaki, P., Tzouganakis, A., Agalianos, C., Tsouknidas, I., Xenakis, A., Chrysos, E., Lasithiotakis, K., Nikolouzakis, T., Xenaki, S., Xynos, E., Lostoridis, E., Nagorni, E. -A., Pujante, A., Tourountzi, P., Al, A., Baxevanidou, K., Bouliaris, K., Efthimiou, M., Kalfountzos, C., Koukoulis, G., Lachanas, V., Petropoulos, K., Tsitiridis, I., Angelis, F., Arnaoutoglou, E., Baloyiannis, I., Bareka, M., Bouronikou, A., Christodoulidis, G., Daponte, A., Fergadi, M., Gkolias, N., Gkrinia, E., Hajiioannou, J., Kalogritsas, N., Karoni, E., Korais, C., Krestinidis, G., Ktisti, A., Magouliotis, D., Maiou, C., Malizos, K., Minasidou, M., Ntalouka, M., Ntziovara, A. M., Palla, E., Perivoliotis, K., Saini, F., Samara, A., Saratziotis, A., Skoulakis, C., Solomi, E., Stamoulis, K., Terzoudis, C. D., Tsironi, E., Tzovaras, G., Vallianou, K., Zacharoulis, D., Ziogkou, A., Elias, L., Maroulis, I., Mulita, F., Plachouri, K. -M., Vailas, M., Doitsidis, C., Filo, E., Gkalonaki, I., Kogia, E., Kontopoulou, K., Mitroudi, M., Panteli, C., Patoulias, I., Semkoglou, O. I., Sfoungaris, D., Valioulis, I., Astreidis, I., Christidis, P., Ioannidis, O., Loutzidou, L., Mantevas, A., Paraskevopoulos, K., Tatsis, D., Athanasiadis, A., Dagklis, T., Kalogiannidis, I., Kapetanios, G., Mamopoulos, A., Margioula-Siarkou, C., Petousis, S., Tsakiridis, I., Anthoulakis, C., Christou, C., Fantakis, A., Iordanidou, E., Kaselas, C., Panagiotidou, S., Papadopoulos, V., Papavasiliou, K., Piachas, A., Siasios, I., Spyridakis, I., Theodoridis, T., Tooulias, A., Tsiridis, E., Tsopozidi, M., Aleman, M., Brolo, E., Lemus, A. L., Greenberg, J., Chew, K. M. M., Oliva, J. R., Lima, M. A. D. L., Muralles, I. L., Solares, F., Ajcip, G., Anton, C., Cojulun, J., Flores, M. -A., Jose, N., Paiz, C. A. M., Morales, S., Najera, R., Lorenzana, E. Q., Rivera, P., Rodas, L., Santos, V., Sosa, D., Ybarra, N., Cajti, J. D. P., Regil, C., Osorio, W. A., Arriola, R. R., Tale-Rosales, L. -F., Herrera, D., Rodriguez, S. T. T., Villeda, S. A., Anicetti, J., Medina, A. M. L., Ardebol, J., Barillas, K., De Leon, F., Recinos, S., Marroquin-Alpirez, M. -A., Yax, Y., Hon, S., Liu, Y. H., Liu, A. Q., Liu, S., Chiu, H. T. N., Chow, C. M. T., Hau, V., Ip, H. W., Mak, B., Mok, C. Y., Ng, D., Siu, Y. Y. E., Wong, K. F., Pu, J. J., Su, Y. -X., Au-Yeung, K. Y., Chan, D. Y. C., Chan, A., Chan, S. M., Chang, T. C., Chiu, T. W., Chiu, W. K., He, Z., Ho, M. F., Ho, K. K. W., Ho, J. Y. K., Kung, J. W. C., Lam, C. H., Lau, R. W. H., Ling, S. K. K., Lok, H. T., Mak, T. W. C., Ng, C. -F., Ng, S., Ng, K. K. -C., Ng, C. S. H., Ong, M. T. Y., Tan, T., Tang, S. F., Teoh, J. Y. -C., Teoh, A., Tsui, B. S. Y., Wong, G. K. C., Wong, R., Wong, K. C., Yee, C. H., Antal, Z., Kalman, A., Voros, P., Bahrehmand, K., Echim, T., Novak, Z., Sztipits, T., Bihari, L. A., Hidi, L., Piros, L., Rozsa, B., Sotonyi, P., Szatai, L., Herczeg, G., Pordany, B., Tornyi, F., Dede, K., Egyed, T., Saftics, G., Kulcsicka-Gut, J., Sipos, Z., Toth, D., Patel, B., Majmudar, H., Mankad, S., Pathan, S., Sharathkumarkl, L., Sasatti, L., Mahankali, S., Annayappa, S. K. S., Agrawal, T., Anandan, P., Baindur, A., Bd, M., Savitha, C., Anitha, G. S., Harigond, S., Tejeswini, K. K., Kesarla, V., Manangi, M., Hareesh, P. B., Ranjan, J. K. R., Shetty, A., Chikkanayakanahalli, S. S., Sunil, T., Syamala, S., Tharanath, K., Atal, A., Rajagopal, N., Srinath, B. S., Nk, V., Thirumanikandan, P. L., Mishra, N., Shrivastava, S., Wadhwani, R., Ahmad, R., Haq, Z. A., Behera, P., Dhurwe, R., Haq, R., Jain, V., Karna, S., Pushpalatha, K., Raj, S., Santoshi, J. A., Singh, P., Verma, V., Waindeskar, V., Yadav, M. S., Aziz, Z., Chakraborty, K., Chappity, P., Das, G., Datta, D., Jena, S. K., Kar, M., Khuntia, S., Kumar, P., Kumar, R., Kv, A., Mishra, A., Mishra, S., Mittal, Y., Muduly, D., Panda, R., Panigrahi, S., Parija, S., Patra, S., Rout, B., Sahu, R., Sarkar, S., Singh, S., Sudha, S., Sultania, M., Tripathy, S., Varghese, P., Kansay, R., Kaushik, R., Gupta, S. K., Khare, S., Kumar, V., Mohindra, S., Patil, N., Salunke, P., Savlania, A., Singh, K., Pradeep Krishna, R. V., Narasimhan, G., Rela, M., Appukuttan, A., Goudar, S., Mallick, S., Titus, C., Chidambarasamy, E. S., Madhavan, D., Murugesan, A., Narayanasamy, K., Barani Kumar, P. B., Rajan, F., Vijayaragavan, P., Borthakur, B., Chauhan, T. S., Govil, A., Hanjoora, V. M., Srivastava, A., Tiwari, S., Vishwani, V., Pendyala, K. S., Prasad, N., Bothra, J., Deb, M., Herle, K., Jayaram, H., Kannaiyan, L., Krithiga, A., Mukta, W., Nagpal, P., Pathak, P., Banerjee, S., Chaudhary, R., Choudhary, G. R., Chugh, A., Dixit, P., Elhence, A., Gahlot, N., Garg, M., Ghuman, N. K., Jha, D., Kala, P., Kaur, A., Madduri, V., Pandey, H., Pareek, P., Pathak, M., Rathod, K. J., Rodha, M. S., Saxena, R., Sharma, N., Shekhar, S., Singh, M., Suryanarayanan, B., Vishnoi, J. R., Amin, S., Sharma, T., Murugesan, K., Ramasamy, A. B. S., Chatterjee, D., Gerber, C. G., Naskar, U., Aggarwal, G., Agrawal, S. K., Jain, P., Jain, D., Kewlani, V., Pipara, A., Priya, N., Raja, R., Shakya, S., Thambudorai, R., Kharkongor, D., Akhtar, N., Anand, A., Asnani, M., Chaturvedi, A., Chaurasia, A., Enny, L. E., Garg, S., Jaiswal, A. K., Jaiswal, S., Jaware, Y., Kala, N., Karnatak, R., Kumar, U., Shrivastava, A. K., Mehrotra, S., Mishra, B., Namrata, Ojha, B. K., Ozair, A., Pal, U. S., Pandey, A., Raja, N., Ramakant, P., Roy, A., Sachan, R., Sankhwar, S., Sankhwar, P., Sarin, D., Shukla, A., Singh, K. R., Singh, R., Singh, U., Solanki, V., Sonkar, A. A., Srivastava, C., Suryawanshi, P., Tewarson, V., Verma, R., Verma, M. L., Yadav, A., Chand, G., Chanthar, K. M. M. V., Hoysal, D., Batra, N., Bhatti, A., Chopra, R., David, S., Dhar, T., Dutt, U. K., Dutta, R., Gandhi, S., Haque, P. D., Paul Sudhakar John, B., Veetil, S. K., Kaur, G., Kumar, N., Luther, A., Mahajan, A., Mandrelle, K., Mathews, S., Michael, V., Mukherjee, P., Pargal, P., Paul, R., Phillip, A., Phillips, R., Samuel, A., Singh, N., Singh, I., Singh, A., Grewal, S. S., Singhania, A., Thirumalai, S., Varghese, A., Wesley, J., Thomas, J., Zechariah, P., Ifthikar, M. A., Mathew, R. T., Shetty, R., Vijaykumar, M. V., Hameed, B. M. Z., Ibrahim, S., Jyothish, G., Krishna, S., Mathew, S., Kumar, A. S., Sinha, P. K., Sridhar, R., Agarwal, S., Balasubramaniam, S., Chhatrapati, S., Deshpande, C., Dharia, A., Fernandes, S., Gore, M., Jayakumar, A., Mhamane, R., Nirgude, A., Parab, S., Patil, M., Peswani, A., Sahu, A., Samel, S., Shah, F., Haridas, D., Shetty, V., Abraham, B., Agarwal, V., Ahmad, Q., Asari, A., Attar, M. I., Ayyalasomayajula, N. S., Bachawat, S., Bachhav, S., Badhe, V., Badhwar, S., Basa, V. I. K. A. S., Bothara, V., Chattopadhyay, S., Chaudhari, S., Chavan, R., Chawathe, P., Dadhich, S., Dalal, A., Date, A., Deshpande, M., Dev, P., Dongre, N., Doshi, A., Gade, M., Gajjar, S., Gawande, M., Ghalme, A., Ghugare, B., Gupta, I., Jain, M., Jenasamant, S. S., Joshi, V., Kalwadia, N., Kapadia, N., Kattana, H. B. R., Kaushik, T., Kayal, A., Kovale, S., Kulkarni, Y., Kumar, K., Kumawat, K., Lad, V., Maskara, N., Mistry, R., Mohanty, S. R., Motwani, K., Mulchandani, M., Nadkarni, M., Pandey, S., Parab, M., Pardiwala, D., Patkar, A., Pawar, N., Pawar, A., Pednekar, A., Peshattiwar, V., Pokharkar, H., Potdar, O., Pothare, A., Rahmani, F., Rajput, S., Narendra, N. R., Rao, A., Rao, S., Rohela, H., Sakhrekar, R., Salunkhe, D., Sandlas, G., Sarkar, H., Satpathy, A., Sekhar, R., Shelke, Y., Shetty, S. S., Shetye, S., Kulkarni, A. S., Singal, U., Solanki, F., Sonawane, R., Thete, R., Vhatkar, R., Vora, S., Waigankar, S., Wasnik, S., Yadav, M., Yedave, R., Acharya, H., Bangar, A., Bharucha, M., Dhumane, P., Karmarkar, S., Nathani, R., Nehe, A., Nene, A., Noronha, W. J., Palapalle, N., Patel, P., Poyyil, D., Redkar, R., Shah, M., Tewari, S., Bakshi, G., Chaudhari, V., Deshmukh, A., Desoouza, A., Nair, D., Nayak, P., Patkar, S., Puri, A., Qureshi, S., Shetty, P., Shylasree, T., Thakkar, P., Thiagarajan, S., Tiwari, V. K., Voppuru, S. R., Soni, A., Soni, G., Alam, J., Bagaria, D., Bajpai, M., Bisoi, A. K., Chauhan, S., Choudhary, N., Chouhan, R. S., Chumber, S., Farooque, K., Gudala, V., Joshi, M., Kabra, A., Kale, S. S., Kumar, S., Mahajan, D., Malhotra, R., Menon, P. R., Misra, B., Mittal, S., Parshad, R., Priyadarshini, P., Sagar, S., Sharma, P. B., Sharma, V., Trikha, V., Tyagi, M., Bansal, K., Varma, K., Bhardwaj, R., Mittal, A., Ponnusamy, S., Singh, G. R., Tuli, I., Bhor, P., Dhar, S., Kale, S., Aggarwal, M., Gupta, H., Deshpande, A., Gadekar, A., Jaysingani, T., Panjwani, T., Patil, R., Vaidya, N., Vishwakarma, S. K., Wayal, U., Dutta, D., Arora, R., Dhingra, M., Garg, P. K., Huda, F., Kandwal, P., Kant, R., Seenivasagam, R. K., Joshua, L. M., Poonia, D. R., Rajput, D., Sadhasivam, S., Singh, V., Chandanwale, K., Philip, M., Thorat, V., Choudhury, Y., Das, D., Das, M., Goala, S., Laskar, F. Y., Laskar, P., Malik, K., Sarkar, A., Singha, S. T., Singha, M. N., Singha, D., Srungavarapu, G., Tapkire, R., Tling, S., Andrabi, S. M. I., Bhat, G. A., Chowdri, N., Kour, R., Parray, F., Shah, Z. A. M. I. R. A. H. M. A. D., Wani, R., Adamala, S., Gowder, R., Hegde, S., Mashitha, M. S., Sreeram, S., Ankadavar, S., Bafna, D., Dhanani, B., Ingle, N., Jadhao, P., Joseph, S., Kapote, S., Karkada, S., Lad, P., Lohia, R., Madje, S., Narasiman, V., Chisthi, M., George, G., Jothi, H., Pareed, D., Mathew, G. D. C., Abel, L., Agrawal, M., Rabindranath, B., Baldia, M., Barla, R. K., Beck, M., Benjamin, S., Bliss, J., Cherian, L., Devarakonda, S., Ete, G., George, A. J. P., Iovino, Claudio, CovidSurg Collaborarive, Frisoni T., Palmerini E., Donati D., Traina F., Solaini L., Pignatti M., Conti A., Internal Medicine, Collaborative, COVIDSurg, Collaborative, GlobalSurg, Apollo - University of Cambridge Repository, COVIDSurg Collaborative, Li, E, Emanuele Cammarata, Sofia Campanella, Daniela Canzonieri, Adriana Cordova, Federico De Michele, Ettore Dinoto, Mara Franza, Leo Licari, Daniele Matta, Domenico Mirabella, Felice Pecoraro, Roberto Pirrello, Pierfrancesco Pugliese, Fernando Rosatti, Giuseppe Salamone, Francesca Toia, Massimiliano Tripoli, Vito Chiantera, Leo Licari, Palmisano, Silvia, de Manzini, Nicolo', Collaborative, Covidsurg, Collaborative, Globalsurg, Faculty of Medicine and Pharmacy, Clinical sciences, Medical Oncology, Basic (bio-) Medical Sciences, Diabetes Pathology & Therapy, Gastroenterology, Fruscio, R, Ornaghi, S, Surgical clinical sciences, COVIDSurg Collaborative (GlobalSurg, Collaborative), Beretta, L, and Aldrighetti, L.
Subjects: Male, pulmonary embolism, Internationality, Settore MED/18 - CHIRURGIA GENERALE, Deep vein, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], infectious diseases, Cardiovascular, SARS‐CoV‐2, surgery, COVID-19, SARS-CoV-2, deep vein thrombosis, venous thromboembolism, Cohort Studies, Postoperative Complications, Anesthesiology, Medicine and Health Sciences, Prospective Studies, 610 Medicine & health, Prospective cohort study, Lung, 11 Medical and Health Sciences, Confounding, Hematology, Middle Aged, Thrombosis, 17 Psychology and Cognitive Sciences, Pulmonary embolism, medicine.anatomical_structure, Cohort, COVID-19/complications, Postoperative Complications/etiology, Original Article, Female, Patient Safety, Life Sciences & Biomedicine, Human, Adult, medicine.medical_specialty, Adolescent, Clinical Sciences, GlobalSurg Collaborative, Venous Thromboembolism/etiology, NO, COVIDSurg Collaborative, Young Adult, Medicine, General & Internal, Age Distribution, Clinical Research, COVID‐19, General & Internal Medicine, medicine, Humans, Sex Distribution, Aged, Science & Technology, business.industry, Prevention, Neurosciences, deep vein thrombosi, Pneumonia, Odds ratio, Original Articles, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Prospective Studie, Good Health and Well Being, Anesthesiology and Pain Medicine, Human medicine, Postoperative Complication, Cohort Studie, business, Venous thromboembolism, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly. ispartof: ANAESTHESIA vol:77 issue:1 pages:28-39 ispartof: location:England status: published
Published: 2022

24. Sex matters: association between callous-unemotional traits and uncinate fasciculus microstructure in youths with conduct disorder

Author: Christina Stadler, Ophélie Courbet, Karen Gonzalez-Madruga, Christine M. Freitag, Gregor Kohls, Graeme Fairchild, Jack C. Rogers, Thomas Villemonteix, Kerstin Konrad, Nora Maria Raschle, and Stephane A. De Brito
Subjects: Callous unemotional, Cognitive Neuroscience, Psychopathy, Neuropsychology, Uncinate fasciculus, medicine.disease, Sexual dimorphism, White matter, Behavioral Neuroscience, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Neurology, Conduct disorder, medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Association (psychology), Psychology, Clinical psychology
Abstract: Among youths with conduct disorder, those with callous-unemotional traits are at increased risk for persistent antisocial behaviour. Although callous-unemotional traits have been found to be associated with white-matter brain abnormalities, previous diffusion imaging studies were conducted in small samples, preventing examination of potential sex by callous-unemotional traits interaction effects on white matter. Here, we used tract-based spatial statistics at a whole-brain level and within regions of interest to compare the white matter correlates of callous-unemotional traits in female vs. male youths with conduct disorder, in a sample (n = 124) recruited through a multi-site protocol. A sex-specific association between callous-unemotional traits and white matter was found in the left uncinate fasciculus, where callous-unemotional traits were positively associated with axial diffusivity in males, while an opposite pattern was found in females. These findings are in line with previous studies suggesting that the uncinate fasciculus is a key tract implicated in the development of psychopathy, but also add to recent evidence showing that sexual dimorphism needs to be taken into account when examining the structural correlates of mental disorders in general, and callous-unemotional traits in conduct disorder in particular.
Published: 2021

25. Exaggerated ventilatory drive estimates from epiglottic and esophageal pressure deflections in the presence of airway occlusion

Author: Daniel L. Stadler, Peter Catcheside, Karen J. Reynolds, and Laura K. Gell
Subjects: medicine.medical_specialty, Physiology, Respiratory physiology, Epiglottis, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, Occlusion, Positive airway pressure, medicine, Humans, Respiratory system, Lung, Pressure gradient, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, business.industry, Airway obstruction, medicine.disease, respiratory tract diseases, Airway Obstruction, Obstructive sleep apnea, 030228 respiratory system, Cardiology, Airway, business, 030217 neurology & neurosurgery
Abstract: Esophageal and epiglottic pressure deflections are widely used to quantify ventilatory effort during sleep in patients with obstructive sleep apnea (OSA). However, changes in upper airway patency will fundamentally alter pressure gradients across the respiratory system with different airflow and volume-dependent effects on esophageal versus epiglottic pressure. The magnitude of these obstruction effects on ventilatory effort assessed from pressure deflections has not been systematically investigated. This study sought to quantify the direct effect of airway occlusion on esophageal and epiglottic pressure deflections during sleep in patients with OSA compared with predictions based on classic respiratory mechanics. Pneumotachograph airflow and volume, and esophageal, epiglottic, mask, and gastric pressures were measured throughout a nonoccluded breath before and the first occluded breath after repeated external airway occlusions during sleep in 13 patients with OSA on constant positive airway pressure (CPAP). Inspiratory pressure deflections were approximately doubled with epiglottic pressure, and increased by around 40% with esophageal pressure on the occluded compared with the preoccluded breath. Differences in pressure between pre- and occluded breaths showed strong dependence on volume and flow, in line with theoretical models of respiratory mechanics. A relatively simple correction factor could account for these effects to provide more consistent measures of ventilatory effort from pressure, independent from measurement site and changing airflow conditions. These finding have important implications for interpreting ventilatory effort and arousal threshold measurements and for understanding the relationships between underlying ventilatory drive and pressure deflections in the presence of airway obstruction during sleep.NEW & NOTEWORTHY Esophageal and epiglottic pressure deflection measurements are widely used as gold-standard measures of ventilatory effort without consideration of differential obstruction effects between measurement sites. This study is the first to quantify the effect of airway occlusion on pressure recordings during sleep. The findings of substantial acute effects of occlusion itself on pressure deflections are important to consider in the planning, analysis, and interpretation of studies that make inferences regarding inspiratory effort.
Published: 2021

26. Bail‐out treatment of pulmonary embolism using a large‐bore aspiration mechanical thrombectomy device

Author: Stefan Stadler, Samuel Sossalla, Lars S. Maier, Markus Ritzka, and Kurt Debl
Subjects: medicine.medical_specialty, Thrombus aspiration, medicine.medical_treatment, 610 Medizin, Case Report, Case Reports, Pulmonary embolism, Large-bore aspiration mechanical thrombectomy device, FlowTriever, Veno-arterial ECMO, Internal medicine, medicine, Extracorporeal membrane oxygenation, Diseases of the circulatory (Cardiovascular) system, Veno‐arterial ECMO, Large‐bore aspiration mechanical thrombectomy device, ddc:610, Ventricular function, business.industry, Acute right heart failure, Thrombolysis, medicine.disease, Mechanical thrombectomy, surgical procedures, operative, Heart failure, RC666-701, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: We report on the first pulmonary embolism treatment via the large‐bore aspiration mechanical thrombectomy device (Inari FlowTriever®) outside the USA, in a resuscitated patient on veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) suffering from severe and acute right heart failure. In this particular high‐risk patient population, where thrombolysis is mostly not applicable, this new technology could be a promising solution as the combination of large‐bore thrombus aspiration and extraction successfully removes large emboli. In our case, right ventricular function improved rapidly after the procedure, ECMO could be weaned, and the patient was dismissed 2 weeks after. In summary, we provide a new therapeutic option for the often difficult treatment of pulmonary embolism in high‐risk patients on VA‐ECMO.
Published: 2021

27. Development and validation of a risk score for predicting positivity of blood cultures and mortality in patients with bacteremia and fungemia

Author: Juliette Cieslinski, Raquel Zanella Bertoldo, João Paulo Telles, Marilia Burdini Borghi, Victoria Stadler Tasca Ribeiro, and Felipe Francisco Tuon
Subjects: Adult, Microbiological Techniques, medicine.medical_specialty, Clinical Microbiology - Research Paper, Bacteremia, Microbiology, Cohort Studies, Predictive Value of Tests, Risk Factors, Internal medicine, Epidemiology, Media Technology, Humans, Medicine, Blood culture, Prospective Studies, Survival analysis, Fungemia, Aged, Retrospective Studies, Models, Statistical, Framingham Risk Score, medicine.diagnostic_test, business.industry, Reproducibility of Results, Middle Aged, medicine.disease, Mean blood pressure, ROC Curve, Blood Culture, Cohort, business, Brazil
Abstract: INTRODUCTION: Bacteremia is a major cause of morbidity and mortality in hospitalized patients. Predictors of mortality are critical for the management and survival of hospitalized patients. The objective of this study was to determine the factors related to blood culture positivity and the risk factors for mortality in patients whose blood cultures were collected. METHODS: A prospective 2-cohort study (derivation with 784 patients and validation with 380 patients) based on the Pitt bacteremia score for all patients undergoing blood culture collection. The score was obtained from multivariate analysis. The Kaplan–Meier survival curve of the cohort derivation and the cohort validation groups was calculated, and the difference was assessed using a log-rank test. Mortality-related factors were older age, extended hospitalization, > 10% of immature cells in the leukogram, lower mean blood pressure, elevated heart rate, elevated WBC count, and elevated respiratory rate. These continuous variables were dichotomized according to their significance level, and a cut-off limit was created. RESULTS: The area under the ROC curve (AUC) was 0.789. The score was validated in a group of 380 patients who were prospectively evaluated. CONCLUSION: Prolonged hospitalization, body temperature, and elevated heart rate were related to positive blood cultures. The Pitt score can be used to assess the risk of death; however it can be individualized according to the epidemiology of each hospital.
Published: 2021

28. Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

Author: Sebastian Reith, Brecht A. G. Willems, Michael J. Jacobs, Elham Bidar, Barend Mees, Ehsan Natour, Nadina Stadler, Nikolaus Marx, Malgorzata Furmanik, Mathias Burgmaier, Kathrin Burgmaier, Sylvia Heeneman, Leon J. Schurgers, Ploingarm Petsophonsakul, Florian Kahles, Chris P. M. Reutelingsperger, Felix Gremse, RS: Carim - B02 Vascular aspects thrombosis and Haemostasis, Biochemie, Pathologie, RS: Carim - B07 The vulnerable plaque: makers and markers, MUMC+: MA Med Staf Spec CTC (9), RS: Carim - V04 Surgical intervention, CTC, MUMC+: Hart en Vaat Centrum (3), RS: Carim - V03 Regenerative and reconstructive medicine vascular disease, MUMC+: *HVC European Venous Centre (9), Vascular Surgery, MUMC+: MA Vaatchirurgie CVC (3), and MUMC+: MA Med Staf Spec Vaatchirurgie (9)
Subjects: CORONARY-ARTERY CALCIFICATION, 0301 basic medicine, Nicotine, medicine.medical_specialty, Vascular smooth muscle, CALCIUM-PHOSPHATE, Physiology, Myocytes, Smooth Muscle, 030204 cardiovascular system & hematology, SUBCLINICAL ATHEROSCLEROSIS, UP-REGULATION, medicine.disease_cause, Muscle, Smooth, Vascular, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, AORTIC-ANEURYSMS, medicine, Humans, Secretion, FETUIN-A, VITAMIN-K, Vascular Calcification, Cells, Cultured, Chemistry, NECROSIS-FACTOR-ALPHA, X-Ray Microtomography, Extracellular vesicle, Atherosclerosis, medicine.disease, Oxidative Stress, Nicotinic acetylcholine receptor, 030104 developmental biology, Endocrinology, NADPH Oxidase 5, Nicotine Vascular calcification Vascular smooth muscle cell phenotypic switching Nox5 Vitamin K2, CARDIOVASCULAR-DISEASE, Cardiovascular Diseases, Calcium, CIGARETTE-SMOKING, Cardiology and Cardiovascular Medicine, Intracellular, Oxidative stress, Calcification, medicine.drug
Abstract: Aims Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences cardiovascular disease resulting in accelerated atherosclerosis and vascular calcification are unknown. The aim of this study was to investigate effects of nicotine on initiation of vascular smooth muscle cell (VSMC) calcification and to elucidate underlying mechanisms. Methods and results We assessed vascular calcification of 62 carotid lesions of both smoking and non-smoking patients using ex vivo micro-computed tomography (µCT) scanning. Calcification was present more often in carotid plaques of smokers (n = 22 of 30, 73.3%) compared to non-smokers (n = 11 of 32, 34.3%; P Conclusion In this study, we provide evidence that nicotine induces Nox5-mediated pro-calcific processes as novel mechanism of increased atherosclerotic calcification. We identified that activation of α7 and α3 nAChR by nicotine increases intracellular Ca2+ and initiates calcification of hVSMCs through increased Nox5 activity, leading to oxidative stress-mediated EV release. Identifying the role of Nox5-induced oxidative stress opens novel avenues for diagnosis and treatment of smoking-induced cardiovascular disease.
Published: 2021

29. Paired Tumor-Normal Sequencing Provides Insights Into the TP53-Related Cancer Spectrum in Patients With Li-Fraumeni Syndrome

Author: M. Herman Chui, Ciyu Yang, Maksym Misyura, Zsofia K. Stadler, Jorge S. Reis-Filho, Gowtham Jayakumaran, Sowmya Jairam, Ryan Ptashkin, Nikita Mehta, Marc Ladanyi, Ozge Ceyhan-Birsoy, Kenneth Offit, Anna Maio, Yirong Li, Yelena Kemel, Mark E. Robson, Maria I. Carlo, Margaret Sheehan, Alicia Latham, Pier Selenica, Ahmet Zehir, Erin E. Salo-Mullen, Michael Walsh, Umut Aypar, and Diana Mandelker
Subjects: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Somatic cell, Cancer, medicine.disease, DNA sequencing, Germline, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, Immunohistochemistry, Li fraumeni, Allele, business, Genetic testing
Abstract: Background Genetic testing for Li-Fraumeni syndrome (LFS) is performed by using blood specimens from patients selected based on phenotype-dependent guidelines. This approach is problematic for understanding the LFS clinical spectrum because patients with nonclassical presentations are missed, clonal hematopoiesis–related somatic blood alterations cannot be distinguished from germline variants, and unrelated tumors cannot be differentiated from those driven by germline TP53 defects. Methods To provide insights into the LFS-related cancer spectrum, we analyzed paired tumor-blood DNA sequencing results in 17 922 patients with cancer and distinguished clonal hematopoiesis–related, mosaic, and germline TP53 variants. Loss of heterozygosity and TP53 mutational status were assessed in tumors, followed by immunohistochemistry for p53 expression on a subset to identify those lacking biallelic TP53 inactivation. Results Pathogenic/likely pathogenic TP53 variants were identified in 50 patients, 12 (24.0%) of which were clonal hematopoiesis related and 4 (8.0%) of which were mosaic. Twelve (35.3%) of 34 patients with germline TP53 variants did not meet LFS testing criteria. Loss of heterozygosity of germline TP53 variant was observed in 96.0% (95% confidence interval [CI] = 79.7% to 99.9%) of core LFS spectrum–type tumors vs 45.5% (95% CI = 16.8% to 76.6%) of other tumors and 91.3% (95% CI = 72.0% to 98.9%) of tumors from patients who met LFS testing criteria vs 61.5% (95% CI = 31.6% to 86.1%) of tumors from patients who did not. Tumors retaining the wild-type TP53 allele exhibited wild-type p53 expression. Conclusions Our results indicate that some TP53 variants identified in blood-only sequencing are not germline and a substantial proportion of patients with LFS are missed based on current testing guidelines. Additionally, a subset of tumors from patients with LFS do not have biallelic TP53 inactivation and may represent cancers unrelated to their germline TP53 defect.
Published: 2021

30. A Coordinated Clinical Center for Young Onset Colorectal Cancer

Author: Ashley Arkema, Robin B. Mendelsohn, Randze Lerie Palmaira, Rosemary Semler, Andrea Cercek, Melissa Lumish, Asha Krishnan, Jill A Weiss, Jeanne Carter, Hadley Maya, Julio Garcia-Aguilar, Zsofia K. Stadler, John P. Mulhall, Anne Casson, Joseph Bacani, and Christian J. Nelson
Subjects: Complex care needs, Program evaluation, Oncology, Cancer Research, medicine.medical_specialty, business.industry, Colorectal cancer, Young onset, Rectum, Cancer, medicine.disease, humanities, Commentaries, Internal medicine, medicine, Humans, Center (algebra and category theory), Colorectal Neoplasms, business
Abstract: The increase in young onset colorectal cancer and the complex care needs of young cancer patients spurred the development of the Center for Young Onset Colorectal Cancer at the Memorial Sloan Kettering Cancer Center. This article describes the lessons of the first 2 years at the Center, including development of the program and specific services provided.
Published: 2021

31. Intermediate to long-term clinical outcomes and survival analysis of the Salto Mobile Bearing total ankle prothesis

Author: Lorenz Pisecky, M C Klotz, B Ruhs, Stella Stevoska, C Kaufmann, M Stöbich, Tobias Gotterbarm, and Christian Stadler
Subjects: Reoperation, medicine.medical_specialty, Joint replacement, Joint Prosthesis, Arthrodesis, medicine.medical_treatment, Osteoarthritis, Arthroplasty, Replacement, Ankle, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Orthopedics and Sports Medicine, Survival rate, Retrospective Studies, 030203 arthritis & rheumatology, 030222 orthopedics, business.industry, General Medicine, medicine.disease, Survival Analysis, Surgery, Prothesis, Treatment Outcome, medicine.anatomical_structure, Orthopedic surgery, Ankle, business, Range of motion, Ankle Joint
Abstract: Introduction Osteoarthritis of the ankle is a major burden to affected patients. While tibio-talar arthrodesis has been the gold-standard regarding the treatment of osteoarthritis of the ankle joint for many years, at present total ankle arthroplasty (TAA) provides appealing clinical outcomes and is continually gaining popularity. The aim of this study was to evaluate the intermediate- to long-term clinical outcome including the survival rate of Salto Mobile Bearing TAA (Tonier SA, Saint Ismier, France). Material and methods In this retrospective study intermediate- to long-term outcomes measures [Ankle Range of Motion (ROM), American Orthopaedic Foot and Ankle Score (AOFAS score) and survival rate] of 171 consecutive TAA were analysed and compared before and after surgery. Revision was defined as secondary surgery with prothesis component removal, while reoperation was defined as a non-revisional secondary surgery involving the ankle. Results At a mean follow-up (FU) period of 7.2 ± 2.7 years (range 2.0 to 14.1 years) there was a significant improvement in ankle ROM (total ROM improved from 25.0° ± 15.0° to 28.7° ± 11.3°, p = 0.015; plantarflexion improved from 18.4° ± 11.7° to 20.6° ± 8.2°, p = 0.044; dorsiflexion improved from 6.6° ± 5.7° to 8.1° ± 4.9°, p = 0.011). AOFAS score increased significantly by 41 ± 15 points after surgery (43.3 ± 11.1 before and 84.3 ± 12.0 after surgery, p Conclusion This study endorses the previously reported appealing intermediate- to long-term outcomes of the Salto Mobile Bearing TAA. There was a significant increase in ROM and AOFAS score as well as decent implant survival at final FU.
Published: 2021

32. Randomized phase 3 ALCANZA study of brentuximab vedotin vs physician's choice in cutaneous T-cell lymphoma: final data

Author: Steven M. Horwitz, Jan Walewski, David C. Fisher, Meredith Little, Judith Trotman, Rudolf Stadler, Pablo L. Ortiz-Romero, Pier Luigi Zinzani, Reinhard Dummer, Kerry Taylor, Larisa J. Geskin, Madeleine Duvic, Oliver Bechter, Herbert Eradat, Sean Whittaker, José Antonio Sanches, Lauren C. Pinter-Brown, Stéphane Dalle, Julia Scarisbrick, Michael Weichenthal, H. Miles Prince, Veronica Bunn, Julie Lisano, Pietro Quaglino, Oleg E. Akilov, Youn H. Kim, Horwitz S.M., Scarisbrick J.J., Dummer R., Whittaker S., Duvic M., Kim Y.H., Quaglino P., Zinzani P.L., Bechter O., Eradat H., Pinter-Brown L., Akilov O.E., Geskin L., Sanches J.A., Ortiz-Romero P.L., Weichenthal M., Fisher D.C., Walewski J., Trotman J., Taylor K., Dalle S., Stadler R., Lisano J., Bunn V., Little M., and Miles Prince H.
Subjects: Adult, medicine.medical_specialty, Skin Neoplasms, Gastroenterology, Physicians, Internal medicine, medicine, Clinical endpoint, Humans, Lymphoma, T-Cell, Cutaneou, Brentuximab vedotin, Brentuximab Vedotin, Bexarotene, Mycosis fungoides, business.industry, Hazard ratio, Cutaneous T-cell lymphoma, Hematology, medicine.disease, Lymphoma, T-Cell, Cutaneous, Lymphoma, Physician, Quality of Life, Methotrexate, business, Human, medicine.drug
Abstract: The primary analysis of the phase 3 ALCANZA trial showed significantly improved objective responses lasting ≥4 months (ORR4; primary endpoint) and progression-free survival (PFS) with brentuximab vedotin vs physician's choice (methotrexate or bexarotene) in CD30-expressing mycosis fungoides (MF) or primary cutaneous anaplastic large-cell lymphoma (C-ALCL). Cutaneous T-cell lymphomas often cause pruritus and pain; brentuximab vedotin improved skin symptom burden with no negative effects on quality of life. We report final data from ALCANZA (median follow-up, 45.9 months). Adults with previously treated CD30-expressing MF/C-ALCL were randomly assigned to brentuximab vedotin (n = 64) or physician's choice (n = 64). Final data demonstrated improved responses per independent review facility with brentuximab vedotin vs physician's choice: ORR4; 54.7% vs 12.5% (P < .001); complete response, 17.2% vs 1.6% (P = .002). Median PFS with brentuximab vedotin vs physician's choice was 16.7 months vs 3.5 months (P < .001). Median time to the next treatment was significantly longer with brentuximab vedotin than with physician's choice (14.2 vs 5.6 months; hazard ratio, 0.27; 95% confidence interval, 0.17-0.42; P < .001). Of 44 patients in the brentuximab vedotin arm who experienced any-grade peripheral neuropathy, (grade 3, n = 6; grade 4, n = 0), 86% (38 of 44) had complete resolution (26 of 44) or improvement to grades 1 and 2 (12 of 44). Peripheral neuropathy was ongoing in 18 patients (all grades 1-2). These final analyses confirm improved, clinically meaningful, durable responses and longer PFS with brentuximab vedotin vs physician's choice in CD30-expressing MF or C-ALCL. This trial was registered at https://www.clinicaltrials.gov as #NCT01578499. ispartof: BLOOD ADVANCES vol:5 issue:23 pages:5098-5106 ispartof: location:United States status: published
Published: 2021

33. Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC

Author: Youn H. Kim, Lawrence H. Schwartz, José Antonio Sanches, Emmilia Hodak, Ellen J. Kim, Martine Bagot, Julia Scarisbrick, Emmanuella Guenova, Pablo L. Ortiz-Romero, Robert Knobler, Evangelia Papadavid, Jasmine Zain, Michael Girardi, Madeleine Duvic, Alejandro A. Gru, Mary Jo Lechowicz, Makoto Sugaya, Weiyun Z. Ai, Richard T. Hoppe, Gary S. Wood, Maarten H. Vermeer, Elise A. Olsen, Werner Kempf, Larisa J. Geskin, Francine M. Foss, Steven M. Horwitz, Joan Guitart, Rudolf Stadler, Pietro Quaglino, Mark R. Pittelkow, Sean Whittaker, John A. Zic, Lauren C. Pinter-Brown, H. Miles Prince, and Rein Willemze
Subjects: Oncology, medicine.medical_specialty, Skin Neoplasms, Immunology, MEDLINE, Disease, Biochemistry, Cutaneous lymphoma, Mycosis Fungoides, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Sezary Syndrome, Special Report, Neoplasm Staging, Mycosis fungoides, Clinical Trials as Topic, business.industry, Clinical study design, Primary cutaneous lymphoma, Cancer, Cell Biology, Hematology, medicine.disease, United States, Lymphoma, T-Cell, Cutaneous, Clinical trial, business
Abstract: The number of patients with primary cutaneous lymphoma (PCL) relative to other non-Hodgkin lymphomas (NHLs) is small and the number of subtypes large. Although clinical trial guidelines have been published for mycosis fungoides/Sézary syndrome, the most common type of PCL, none exist for the other PCLs. In addition, staging of the PCLs has been evolving based on new data on potential prognostic factors, diagnosis, and assessment methods of both skin and extracutaneous disease and a desire to align the latter with the Lugano guidelines for all NHLs. The International Society for Cutaneous Lymphomas (ISCL), the United States Cutaneous LymphomaConsortium (USCLC), and the Cutaneous Lymphoma Task Force of the European Organization for the Research and Treatment of Cancer (EORTC) now propose updated staging and guidelines for the study design, assessment, endpoints, and response criteria in clinical trials for all the PCLs in alignment with that of the Lugano guidelines. These recommendations provide standardized methodology that should facilitate planning and regulatory approval of new treatments for these lymphomas worldwide, encourage cooperative investigator-initiated trials, and help to assess the comparative efficacy of therapeutic agents tested across sites and studies.
Published: 2022

34. Effects of lifestyle interventions on epigenetic signatures of liver fat: Central randomized controlled trial

Author: Stephan H. Bernhart, Ehud Rinott, Peter F. Stadler, Uta Ceglarek, Matthias Blüher, Peter Kovacs, Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Anat Yaskolka Meir, Gal Tsaban, Hila Zelicha, Luise Müller, Maria Keller, Iris Shai, Michael Stumvoll, and Alon Kaplan
Subjects: Male, Oncology, medicine.medical_specialty, Candidate gene, Context (language use), Disease, Epigenesis, Genetic, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Non-alcoholic Fatty Liver Disease, law, Internal medicine, Nonalcoholic fatty liver disease, Humans, Medicine, Epigenetics, Exercise, Life Style, Hepatology, business.industry, Calcium-Binding Proteins, medicine.disease, Liver, CpG site, 030220 oncology & carcinogenesis, DNA methylation, Female, 030211 gastroenterology & hepatology, business
Abstract: BACKGROUND AND AIMS In the CENTRAL trial context, we found diverse liver fat dynamics in response to different dietary interventions. Epigenetic mechanisms may contribute to the intraindividual variation. Moreover, genetic factors are involved in developing nonalcoholic fatty-liver disease (NAFLD), a disease reflected by an increase in intrahepatic fat (IHF). In this exploratory analysis, we primarily aimed to examine the effect of lifestyle interventions on DNA-methylation of NAFLD related genes associated with IHF. METHODS For 120 participants from the CENTRAL trial, an 18-month regimen of either low-fat (LF) or Mediterranean-low carbohydrate (MED/LC) diets, with or without physical activity (PA+/PA-), was instructed. Magnetic resonance imaging was used to measure IHF%, which was analysed for association with CpG specific DNA-methylation levels of 41 selected candidate genes. Single-nucleotide polymorphisms known to be associated with NAFLD within the studied genes were genotyped by TaqMan assays. RESULTS At baseline, participants (92% men; body mass index = 30.2 kg/m2 ) had mean IHF of 10.7% (59% NAFLD). Baseline-IHF% was inversely correlated with DNA-methylation at individual CpGs within AC074286.1, CRACR2A, A2MP1, FARP1 (P
Published: 2021

35. Efficacy and Safety of Atezolizumab Plus Bevacizumab Following Disease Progression on Atezolizumab or Sunitinib Monotherapy in Patients with Metastatic Renal Cell Carcinoma in IMmotion150: A Randomized Phase 2 Clinical Trial

Author: Cristina Suarez, Mario Sznol, Richard W. Joseph, Beiying Ding, Ning Leng, Alain Ravaud, John D. Hainsworth, Thomas E. Hutson, Brian I. Rini, David F. McDermott, Sergio Bracarda, Sumanta K. Pal, Allen Lee Cohn, Thomas Powles, Walter M. Stadler, James A. Reeves, Mahrukh Huseni, Christina Schiff, Lawrence Fong, Bernard Escudier, Kenji Hashimoto, Toni K. Choueiri, Michael B. Atkins, and Robert J. Motzer
Subjects: Vascular Endothelial Growth Factor A, Oncology, medicine.medical_specialty, Bevacizumab, Urology, 030232 urology & nephrology, Phases of clinical research, Antibodies, Monoclonal, Humanized, urologic and male genital diseases, 03 medical and health sciences, 0302 clinical medicine, Atezolizumab, Renal cell carcinoma, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Sunitinib, medicine, Humans, Adverse effect, Carcinoma, Renal Cell, business.industry, Cancer, medicine.disease, Kidney Neoplasms, 030220 oncology & carcinogenesis, Disease Progression, business, Kidney cancer, medicine.drug
Abstract: Background The use of immune checkpoint inhibitors combined with vascular endothelial growth factor (VEGF)-targeted therapy as second-line treatment for metastatic clear cell renal cancer (mRCC) has not been evaluated prospectively. Objective To evaluate the efficacy and safety of atezolizumab + bevacizumab following disease progression on atezolizumab or sunitinib monotherapy in patients with mRCC. Design, setting, and participants IMmotion150 was a multicenter, randomized, open-label, phase 2 study of patients with untreated mRCC. Patients randomized to the atezolizumab or sunitinib arm who had investigator-assessed progression as per RECIST 1.1 could be treated with second-line atezolizumab + bevacizumab. Intervention Patients received atezolizumab 1200 mg intravenously (IV) plus bevacizumab 15 mg/kg IV every 3 wk following disease progression on either atezolizumab or sunitinib monotherapy. Outcome measurements and statistical analysis The secondary endpoints analyzed during the second-line part of IMmotion150 included objective response rate (ORR), progression-free survival (PFS), and safety. PFS was examined using Kaplan-Meier methods. Results and limitations Fifty-nine patients in the atezolizumab arm and 78 in the sunitinib arm were eligible, and 103 initiated second-line atezolizumab + bevacizumab (atezolizumab arm, n = 44; sunitinib arm, n = 59). ORR (95% confidence interval [CI]) was 27% (19–37%). The median PFS (95% CI) from the start of second line was 8.7 (5.6–13.7) mo. The median event follow-up duration was 19.4 (12.9–21.9) mo among the 25 patients without a PFS event. Eighty-six (83%) patients had treatment-related adverse events; 31 of 103 (30%) had grade 3/4 events. Limitations were the small sample size and selection for progressors. Conclusions The atezolizumab + bevacizumab combination had activity and was tolerable in patients with progression on atezolizumab or sunitinib. Further studies are needed to investigate sequencing strategies in mRCC. Patient summary Patients with advanced kidney cancer whose disease had worsened during treatment with atezolizumab or sunitinib began second-line treatment with atezolizumab + bevacizumab. Tumors shrank in more than one-quarter of patients treated with this combination, and side effects were manageable.
Published: 2021

36. Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes

Author: Fresia Pareja, Arnaud Da Cruz Paula, Karen Cadoo, Timothy Hoang, Nadeem R. Abu-Rustum, Lora H. Ellenson, Gabriel Capellá, August Vidal Bel, Lea A. Moukarzel, Xavier Matias-Guiu, Lorenzo Ferrando, Kay J. Park, Jorge S. Reis-Filho, Ana Paula Martins Sebastiao, Achim A. Jungbluth, Britta Weigelt, Marta Pineda, Jeffrey Levin, and Zsofia K. Stadler
Subjects: Adult, 0301 basic medicine, Pathology, medicine.medical_specialty, Somatic cell, clonality, Ovary, Endometrium, DNA Mismatch Repair, Article, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Neoplastic Syndromes, Hereditary, medicine, Sequencing, Humans, PTEN, Ovarian Neoplasms, Synchronous endometrial and ovarian cancer, Massive parallel sequencing, biology, Brain Neoplasms, sequencing, Syndrome, synchronous endometrial and ovarian cancer, Middle Aged, medicine.disease, Primary tumor, Lynch syndrome, Endometrial Neoplasms, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Mutation, Disease Progression, Cancer research, biology.protein, Female, DNA mismatch repair, Colorectal Neoplasms, Clonality
Abstract: Sporadic synchronous endometrial (ECs) and ovarian cancers (OCs), although clinically considered to be independent primaries, have been shown to be clonally related and likely constitute metastases from each other. We sought to define whether synchronous ECs/OCs in patients with DNA mismatch repair (MMR)-deficiency syndromes would be clonally-related. We subjected synchronous ECs/OCs from four patients (LS3-LS6) with clinically confirmed Lynch syndrome (LS) and one patient with constitutional mismatch repair deficiency syndrome (CMMRD) to massively parallel sequencing targeting 468 cancer-related genes. Somatic mutations, copy number alterations (CNAs), clonal relatedness and clonal decomposition analyses were performed using previously described bioinformatics methods. All synchronous ECs/OCs analyzed were considered independent primaries based on clinicopathologic criteria. Sequencing analysis revealed that the ECs/OCs of three cases (LS2-CMMRD, L3, L4) harbored similar repertoires of somatic mutations and CNAs and were clonally-related. In these three cases, a subset of subclonal mutations in the EC became clonal in the OC, suggesting that the EC was likely the substrate from which the OC developed. LS5’s EC/OC had distinct mutational profiles but shared specific CNAs. In contrast, LS6’s EC/OC harbored distinct somatic mutation and lacked CNAs, consistent with each tumor constituting an independent primary lesion. In LS5 and LS6, PTEN mutations and PTEN loss of protein expression were found to be restricted to the EC. Finally, re-analysis of sequencing data of sporadic synchronous ECs/OCs supported the observations made in the current study that the directionality of progression is likely from the endometrium to the ovary. In conclusion, contrary to sporadic synchronous ECs/OCs, which are almost invariably clonally-related, ECs/OCs simultaneously involving the uterus and ovary in LS patients may represent distinct primary tumors. A subset of MMR-deficiency syndrome-related synchronous ECs/OCs, however, may originate from a single primary tumor at variance with their clinical diagnosis, with the endometrium being the likeliest site of origin. JSR-F was funded in part by a Breast Cancer Research Foundation grant, BW in part by Breast Cancer Research Foundation, Cycle for Survival and Stand Up To Cancer grants, F.P. partially by a National Institutes of Health/ National Cancer Institute K12 CA184746 grant, XM-G by AECC (grupos estables) and GC and MP by the Spanish Ministry of Economy and Competitiveness and co-funded by FEDER funds -a way to build Europe- (grant SAF2015-68016-R), CIBERONC and the Government of Catalonia (grant 2017SGR1282). XM-G, GC and MP thank CERCA Programme for institutional support. Research reported in this publication was supported in part by a Cancer Center Support Grant of the NIH/NCI (Grant No. P30CA008748).
Published: 2021

37. Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantation

Author: Stefan Gingele, Michael Stadler, Arnold Ganser, Florian Wegner, Gudrun Göhring, Martin Bredt, Mike P. Wattjes, Martin Stangel, Martin W. Hümmert, Nora Möhn, Corinna Trebst, Letizia Venturini, Thomas Skripuletz, and Lothar Hambach
Subjects: Male, Transplantation Conditioning, medicine.medical_treatment, Chronic lymphocytic leukemia, Science, Hematopoietic stem cell transplantation, Disease, Article, Antibodies, Cell Line, Immune system, Central Nervous System Diseases, Humans, Transplantation, Homologous, Medicine, Haematological cancer, Multidisciplinary, biology, business.industry, Hematopoietic Stem Cell Transplantation, Peripheral Nervous System Diseases, Immunotherapy, Middle Aged, medicine.disease, Demyelinating diseases, HEK293 Cells, Concomitant, Immunology, biology.protein, Female, Antibody, business, Encephalitis
Abstract: Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a curative treatment for hematologic malignancies. Acute and chronic graft-versus-host disease (GvHD) are the major immune-mediated complications after alloHSCT. However, there is controversy whether neurologic complications after alloHSCT might represent manifestations of GvHD. We report three patients who acquired distinct, severe immune-mediated peripheral or central nervous system diseases after alloHSCT without other, concomitant GvHD manifestations. One patient had been diagnosed with B-cell chronic lymphocytic leukemia and two patients with high risk myelodysplastic syndrome. Patient #1 presented as LGI1- and GAD-IgG positive immune-mediated encephalitis, patient #2 was diagnosed with MOG-IgG positive encephalomyelitis, and patient #3 had chronic inflammatory polyneuropathy associated with SSA(Ro)-IgG positive Sjögren’s syndrome. 100% donor chimerism was detectable in the peripheral blood in all three. The specific antibodies were undetectable in donors’ and patients’ blood before alloHSCT suggesting that the antibodies had arisen from the transplanted donor immune system. Early intensive immunotherapy led to improvement of clinical symptoms and stability of the neurological disease, however, at the cost of losing the graft-versus-malignancy effect in one patient. In conclusion, we provide evidence of isolated, severe allo-immune diseases of the peripheral and central nervous system as complications of alloHSCT (“neuro-GvHD”). Interdisciplinary surveillance and thorough diagnostic work-up are needed for early diagnosis and treatment of neuro-immunologic complications after alloHSCT to improve the otherwise poor outcome.
Published: 2021

38. Der Porcine Respiratory Disease Complex (PRDC) – eine klinische Übersicht

Author: Julia Stadler, Walter Hermanns, Matthias Eddicks, Mathias Ritzmann, and Lina Eddicks
Subjects: Gynecology, medicine.medical_specialty, General Veterinary, Food Animals, business.industry, Respiratory disease, Multifactorial disease, medicine, Treatment resistance, medicine.disease, business
Abstract: ZusammenfassungDer Porcine Respiratory Disease Complex (PRDC) beschreibt eine klinische Kondition, die sich in Form einer häufig therapieresistenten Atemwegsinfektion bei Mastschweinen manifestiert. Die multifaktorielle Ätiologie beinhaltet infektiöse und nicht infektiöse Faktoren. Bei Entstehung und Verlauf des PRDC spielen neben Management und Hygiene v. a. virale und bakterielle Erreger eine bedeutende Rolle. Das Virus des Porzinen Reproduktiven und Respiratorischen Syndroms (PRRSV), das porzine Circovirus Typ 2 (PCV2), Influenza-A-Virus (IAV) und Mycoplasma (M.) hyopneumoniae stellen die relevantesten Erreger dar. Das klinische Bild und die zugrundeliegenden pathomorphologischen Veränderungen können je nach Erregerbeteiligung variieren. Die Komplexität des PRDC erschwert die Diagnose und auch die Prävention auf Bestandsebene. Der Übersichtsartikel gibt einen Einblick in die Pathomorphologie, Pathogenese sowie Inter-Erreger-Interaktionen und zielt darauf ab, praktizierende Tierärztinnen und Tierärzte bei der Diagnose, Befundinterpretation und Prävention des PRDC zu unterstützen.
Published: 2021

39. Active surveillance of metastatic renal cell carcinoma: Results from a prospective observational study (MaRCC)

Author: Christos Kyriakopoulos, Nrupen A. Bhavsar, Michael R. Harrison, Walter M. Stadler, Ulka N. Vaishampayan, Azah Borham, Brant A. Inman, Benjamin A. Gartrell, Mayer Fishman, Jack Mardekian, Daniel J. George, Sumanta K. Pal, Thomas E. Hutson, Che-Kai Tsao, Christopher W. Ryan, Brian A. Costello, Heather S.L. Jim, Leonard Joseph Appleman, Arif Hussain, Ana M. Molina, Hans J. Hammers, Russell K. Pachynski, Yousef Zakharia, and Neeraj Agarwal
Subjects: Cancer Research, medicine.medical_specialty, business.industry, Disease, medicine.disease, Systemic therapy, 03 medical and health sciences, 0302 clinical medicine, Oncology, Quality of life, Renal cell carcinoma, 030220 oncology & carcinogenesis, Internal medicine, Baseline characteristics, Cohort, medicine, Observational study, 030212 general & internal medicine, business, Survival analysis
Abstract: Background Systemic therapy (ST) can be deferred in patients who have metastatic renal cell carcinoma (mRCC) and slow-growing metastases. Currently, this subset of patients managed with active surveillance (AS) is not well described in the literature. Methods This was a prospective observational study of patients with mRCC across 46 US community and academic centers. The objective was to describe baseline characteristics and demographics of patients with mRCC initially managed by AS, reasons for AS, and patient outcomes. Descriptive statistics were used to characterize demographics, baseline characteristics, and patient-related outcomes. Wilcoxon 2-sample rank-sum tests and χ2 tests were used to assess differences between ST and AS cohorts in continuous and categorical variables, respectively. Kaplan-Meier survival curves were used to assess survival. Results Of 504 patients, mRCC was initially managed by AS (n = 143) or ST (n = 305); 56 patients were excluded from the analysis. Disease was present in 69% of patients who received AS, whereas the remaining 31% had no evidence of disease. At data cutoff, 72 of 143 patients (50%) in the AS cohort had not received ST. The median overall survival was not reached (95% CI, 122 months to not estimable) in patients who received AS versus 30 months (95% CI, 25-44 months) in those who received ST. Quality of life at baseline was significantly better in patients who were managed with AS versus ST. Conclusions AS occurs frequently (32%) in real-world clinical practice and appears to be a safe and appropriate alternative to immediate ST in selected patients.
Published: 2021

40. Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma

Author: Kaitlin A. Tkachuk, Leonard B. Saltz, Neil H. Segal, Andrea Cercek, Kenneth Offit, Rona Yaeger, Michael F. Berger, Jinru Shia, Garrett M. Nash, Zalak Patel, Diane Reidy-Lagunes, Rania Sheikh, Jaclyn F. Hechtman, Zsofia K. Stadler, Louise Catherine Connell, Alicia Latham, Martin R. Weiser, Karuna Ganesh, Ahmet Zehir, Julio Garcia-Aguilar, David P. Kelsen, Diana Mandelker, Arnold J. Markowitz, Philip B. Paty, and Nancy E. Kemeny
Subjects: Adult, Male, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, medicine.medical_specialty, Colorectal cancer, Adenocarcinoma, MLH1, DNA Mismatch Repair, complex mixtures, Gastroenterology, Article, Neoplasms, Multiple Primary, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Internal medicine, Intestinal Neoplasms, Intestine, Small, Biomarkers, Tumor, medicine, PMS2, Humans, Germ-Line Mutation, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Microsatellite instability, Middle Aged, Prognosis, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, digestive system diseases, Lynch syndrome, MSH6, 030104 developmental biology, Oncology, MSH2, 030220 oncology & carcinogenesis, Female, Microsatellite Instability, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract: Purpose: The prevalence and clinical characteristics of small bowel adenocarcinomas (SBA) in the setting of Lynch syndrome have not been well studied. We characterized SBA according to DNA mismatch repair and/or microsatellite instability (MMR/MSI) and germline mutation status and compared clinical outcomes. Experimental Design: A single-institution review identified 100 SBAs. Tumors were evaluated for MSI via MSIsensor and/or corresponding MMR protein expression via IHC staining. Germline DNA was analyzed for mutations in known cancer predisposition genes, including MMR (MLH1, MSH2, MSH6, PMS2, and EPCAM). Clinical variables were correlated with MMR/MSI status. Results: Twenty-six percent (26/100; 95% confidence interval, 18.4–35.4) of SBAs exhibited MMR deficiency (MMR-D). Lynch syndrome prevalence was 10% overall and 38.5% among MMR-D SBAs. Median age at SBA diagnosis was similar in non-Lynch syndrome MMR-D versus MMR-proficient (MMR-P) SBAs (65 vs. 61; P = 0.75), but significantly younger in Lynch syndrome (47.5 vs. 61; P = 0.03). The prevalence of synchronous/metachronous cancers was 9% (6/67) in MMR-P versus 34.6% (9/26) in MMR-D SBA, with 66.7% (6/9) of these in Lynch syndrome (P = 0.0002). In the MMR-P group, 52.2% (35/67) of patients presented with metastatic disease, compared with 23.1% (6/26) in the MMR-D group (P = 0.008). In MMR-P stage I/II patients, 88.2% (15/17) recurred, compared with 18.2% (2/11) in the MMR-D group (P = 0.0002). Conclusions: When compared with MMR-P SBA, MMR-D SBA was associated with earlier stage disease and lower recurrence rates, similar to observations in colorectal cancer. With a 38.5% prevalence in MMR-D SBA, germline Lynch syndrome testing in MMR-D SBA is warranted.
Published: 2021

41. Steroid-refractory dermatologic and pulmonary toxicity in a patient on rituximab treated with pembrolizumab for progressive urothelial carcinoma: a case report

Author: Anh Khoa Pham, Aliya N. Husain, Pankti Reid, Christopher R. Shea, Urooba Nadeem, Jacobi Hines, Ellen Daily, and Walter M. Stadler
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, Medical oncology, medicine.medical_treatment, lcsh:Medicine, Azathioprine, Pembrolizumab, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, Immune checkpoint inhibitors, 0302 clinical medicine, Bullous skin diseases, Prednisone, Case report, Medicine, Humans, Aged, Immune-related adverse effects, business.industry, lcsh:R, Immunosuppression, General Medicine, medicine.disease, Rash, Dermatology, Tacrolimus, Pneumonia, 030104 developmental biology, 030220 oncology & carcinogenesis, Rituximab, Steroids, Immunotherapy, medicine.symptom, Neoplasm Recurrence, Local, business, medicine.drug
Abstract: Background Increasingly widespread use of programmed cell death protein 1 (PD-1) immune checkpoint inhibitors (ICIs) for treatment of a variety of progressive malignancies continues to reveal a range of immune-related adverse events (irAEs), necessitating immunosuppressive therapy for management. While a single course of systemic corticosteroids may be sufficient for many irAEs, no clear standard-of-care guidelines exist for steroid-refractory cases. We present an unusual case of a patient who developed several steroid-refractory novel irAEs on pembrolizumab despite ongoing B cell-directed immunosuppressive therapy with rituximab, who ultimately noted resolution of symptoms with tacrolimus, a T-cell-directed immunosuppressant. Case presentation This 72-year-old Caucasian man with Waldenstrom’s macroglobulinemia and myelin-associated glycoprotein (MAG) immunoglobulin M (IgM) antibody-associated neuropathy was being treated with maintenance rituximab and intravenous immunoglobulin when he was started on pembrolizumab (2.26 mg/kg) for metastatic urothelial cancer 31 months after surgery and adjuvant chemotherapy. After his third dose of pembrolizumab, he developed a painful blistering papular rash of the distal extremities. He received two more doses of pembrolizumab before he also developed diarrhea, and it was held; he was initiated on 1 mg/kg prednisone for presumed ICI-induced dermatitis and colitis. Skin biopsy 10 weeks after cessation of pembrolizumab and taper of steroids to 20 mg daily revealed a unique bullous erythema multiforme. He was then admitted with dyspnea and imaging concerning for necrotizing pneumonia, but did not respond to antibiotic therapy. Bronchoscopy and biopsy revealed acute fibrinous organizing pneumonia. His symptoms failed to fully respond to multiple courses of high-dose systemic corticosteroids and a trial of azathioprine, but pneumonia, diarrhea, and skin rash all improved markedly with tacrolimus. The patient has since completed his therapy for tacrolimus, continues off of ICI, and has not experienced a recurrence of any irAEs, though has more recently experienced progression of his cancer. Conclusion Despite immunosuppression with rituximab and intravenous immunoglobulin, two immunomodulators targeting B cells, ICI cessation, and systemic corticosteroid therapy, our patient developed two high-grade unusual irAEs, bullous erythema multiforme and acute fibrinous organizing pneumonia. Our patient’s improvement with tacrolimus can offer critical insight into the pathophysiology of steroid-refractory irAEs.
Published: 2021

42. Combination of brentuximab‐vedotin with skin‐directed therapies extends the time to the next therapeutic line in patients with cutaneous T‐cell lymphoma

Author: René Stranzenbach and Rudolf Stadler
Subjects: Oncology, medicine.medical_specialty, Immunoconjugates, Skin Neoplasms, Ki-1 Antigen, Context (language use), Dermatology, Disease, Tumor excision, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, In patient, Brentuximab vedotin, Aged, Retrospective Studies, Brentuximab Vedotin, business.industry, Cutaneous T-cell lymphoma, medicine.disease, Lymphoma, T-Cell, Cutaneous, Lymphoma, Neoplasm Recurrence, Local, business, Progressive disease, medicine.drug
Abstract: BACKGROUND AND OBJECTIVES Brentuximab vedotin (BV) is a potent therapeutic option for CD30-positive cutaneous T-cell lymphoma. Unlike existing studies, BV and other therapeutic procedures were frequently combined for our patients. In this context, the study aims to analyze the effectiveness and safety of BV in a real-world setting. PATIENTS AND METHODS This is a retrospective monocentric study analyzing treatment outcomes for patients with CD30-positive cutaneous T-cell lymphoma treated with BV. RESULTS 26 patients (median age: 67 years) were included in the study. Patients were treated with 1.8 or 1.2 mg/kg b.w. Complete remission (CR) was reached in 30.8 % of the patients, and the objective response rate (ORR) was 84.6 %. Side effects were seen in 19 of the 26 patients. As a reaction to progressive disease (PD) under BV monotherapy, we included skin-directed procedures such as tumor excision, local radiotherapy, and PUVA for six patients. We re-stabilized the disease and maintained the line of therapy without additional toxicities for a median of seven months longer using this concept. CONCLUSIONS Addition of skin-directed therapies (SDT) after disease progression under BV monotherapy could stabilize the disease's continuous advancement or even lead to partial response, thereby extending the time until the next therapeutic escalation.
Published: 2021

43. Prevalence of potential interactions of medications, including herbs and supplements, before, during, and after chemotherapy in patients with breast and prostate cancer

Author: Raffi Tchekmedyian, Jimin Wu, Connie To, Olufunmilayo I. Olopade, Russell Z. Szmulewitz, Walter M. Stadler, Jamie H. Von Roenn, Holly M. Holmes, Steven To, Nancy Kwon, and Richard T. Lee
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Prescription Drugs, medicine.medical_treatment, Antineoplastic Agents, Breast Neoplasms, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Breast cancer, Surveys and Questionnaires, Internal medicine, Prevalence, medicine, Humans, Drug Interactions, In patient, 030212 general & internal medicine, Medical prescription, Aged, Chemotherapy, business.industry, Prostatic Neoplasms, Cancer, Middle Aged, medicine.disease, Oncology, 030220 oncology & carcinogenesis, Dietary Supplements, Female, business
Abstract: Background The use of herbs and supplements (HS) is common among patients with cancer, yet limited information exists about potential medication interactions (PMIs) with HS use around chemotherapy. Methods Patients with breast or prostate cancer who had recently finished chemotherapy at 2 academic medical centers were surveyed by telephone. Interviewers inquired about all medications, including HS, before, during, and after chemotherapy. Micromedex, Lexicomp, and Natural Medicines Comprehensive Database interaction software programs were used to determine PMIs. Results A total of 67 subjects (age range, 39-77 years) were evaluated in this study. Participants were primarily White patients (73%) with breast cancer (87%). The median number of medications was 11 (range, 2-28) during the entire study and was highest during chemotherapy (7; range, 2-22). Approximately four-fifths (84%) used HS. A total of 1747 PMIs were identified, and they represented 635 unique PMIs across all 3 timeframes, with most occurring during chemotherapy. Prescription-related PMIs (70%) were the most common type, and they were followed by HS-related (56%) and anticancer treatment-related PMIs (22%). Approximately half of the PMIs (54%) were categorized as moderate interactions, and more than one-third (38%) were categorized as major interactions. Patient use of HS increased from 51% during chemotherapy to 66% after chemotherapy, and this correlated with an increased prevalence of HS PMIs (46% to 60%). HS users were more likely to be at risk for a major PMI than non-HS users (92% vs 70%; P = .038). Conclusions The use of HS remains prevalent among patients with cancer and may place them at risk for PMIs both during chemotherapy and after the completion of treatment. Lay summary This study evaluates the risk of potential medication interactions for patients with breast or prostate cancer undergoing chemotherapy. The results show that patients often use herbs and supplements during treatment. Prescription medications are most often associated with medication interactions, which are followed by herb and supplement-related interactions. More than one-third of potential medication interactions are considered major. Patients should be educated about the risk of herb and supplement-related medication interactions during treatment.
Published: 2021

44. Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant

Author: Lubna Begum, Beth Dudley, Zsofia K. Stadler, Lee M. Bass, Jessica E. Ebrahimzadeh, Eve Karloski, Bryson W. Katona, Chinedu Ukaegbu, Suzanne P. MacFarland, Mary K. Riordan, Sapna Syngal, Garrett M. Brodeur, Sarah Scollon, Matthew B. Yurgelun, Kristin Zelley, Petar Mamula, Randall E. Brand, Jennifer M. Weiss, Alicia Latham, Sharon E. Plon, Amanda Ganzak, Douglas S. Fishman, and Xavier Llor
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, education.field_of_study, business.industry, Population, Cancer, Disease, medicine.disease, Lower risk, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, Hamartomatous polyposis, 030220 oncology & carcinogenesis, Internal medicine, medicine, Juvenile polyposis syndrome, Gastrointestinal cancer, Family history, education, business
Abstract: Juvenile polyposis syndrome (JPS) is a clinically diagnosed hamartomatous polyposis syndrome that increases the risk of gastrointestinal cancer. Approximately 40%–50% of JPS is caused by a germline disease-causing variant (DCV) in the SMAD4 or BMPR1A genes. The aim of this study was to characterize the phenotype of DCV-negative JPS and compare it with DCV-positive JPS. Herein, we analyzed a cohort of 145 individuals with JPS from nine institutions, including both pediatric and adult centers. Data analyzed included age at diagnosis, family history, cancer history, need for colectomy/gastrectomy, and polyp number and location. Compared with DCV-positive JPS, DCV-negative JPS was associated with younger age at diagnosis (P < 0.001), lower likelihood of having a family history of JPS (P < 0.001), and a lower risk of colectomy (P = 0.032). None of the DCV-negative individuals had gastric or duodenal polyps, and polyp burden decreased after the first decade compared with DCV-positive JPS. Subgroup analysis between SMAD4 and BMPR1A carriers showed that SMAD4 carriers were more likely to have a family history of JPS and required gastrectomy. Taken together, these data provide the largest phenotypic characterization of individuals with DCV-negative JPS to date, showing that this group has distinct differences compared with JPS due to a SMAD4 or BMPR1A variant. Better understanding of phenotype and cancer risk associated with JPS both with and without a DCV may ultimately allow for individualized management of polyposis and cancer risk. Prevention Relevance: Juvenile Polyposis Syndrome (JPS) is a gastrointestinal cancer predisposition syndrome requiring lifelong surveillance, however there is limited data comparing individuals with and without a germline disease-causing variant in SMAD4 or BMPR1A. Herein we show that individuals with JPS without an underlying disease-causing variant have distinct phenotypic differences including lack of upper gastrointestinal polyps and lower rates of a family history of JPS, suggesting that a different approach to management may be appropriate in this population.
Published: 2021

45. Treating rheumatoid arthritis with leflunomide monotherapy versus combination therapy with methotrexate

Author: Thelma Larocca Skare, Daniel Ampessan Guadagnin, Leonardo Vinicius Mazzali, and Bárbara Stadler Kahlow
Subjects: lcsh:Immunologic diseases. Allergy, musculoskeletal diseases, medicine.medical_specialty, Creatinine, medicine.diagnostic_test, Combination therapy, business.industry, Inflammation, medicine.disease, Gastroenterology, chemistry.chemical_compound, chemistry, Erythrocyte sedimentation rate, Internal medicine, Rheumatoid arthritis, Toxicity, medicine, Original Article, Methotrexate, medicine.symptom, lcsh:RC581-607, skin and connective tissue diseases, business, medicine.drug, Leflunomide
Abstract: Objective Combination therapies have been proposed as a strategy to control inflammation more effectively in patients with rheumatoid arthritis (RA). Few studies examine the combined effect of methotrexate (MTX) and leflunomide (LFN). This study evaluated the symptom control and side effects of the combination of MTX and LFN compared with LFN monotherapy. Methods We conducted a retrospective analysis of 113 patients with RA treated with either LFN alone (n=22) or in combination with MTX (n=91). Data on disease activity score 28 erythrocyte sedimentation rate (DAS-28 ESR), DAS-28 C-reactive protein (DAS-28 CRP), blood cell count, liver enzymes, and creatinine levels were determined. Samples were collected on day 0 (initiation of LFN) and at 6 and 12 months. Results We found no differences between the 2 groups in DAS-28 on day 0 and at 6 and 12 months (p=0.89, p=0.42, and p=0.09, respectively, for DAS-28 ESR; p=0.97, p=0.27, and p=0.63, respectively, for DAS-28 CRP). In addition, we observed no differences in the blood cell count, liver enzymes, and creatinine levels between the treatment groups at any of the time points (all p>0.05). Conclusion Our results suggest that the efficacy of the combined treatment with MTX and LFN is similar to that of LFN alone. No increase in toxicity was observed with the combination therapy.
Published: 2021

46. The RAD51D c.82G>A (p.Val28Met) variant disrupts normal splicing and is associated with hereditary ovarian cancer

Author: Amanda Catchings, Liying Zhang, Vikas Rai, Ciyu Yang, Angela G. Arnold, and Zsofia K. Stadler
Subjects: 0301 basic medicine, Cancer Research, RNA Splicing, Biology, Article, 03 medical and health sciences, Exon, 0302 clinical medicine, Breast cancer, medicine, Humans, Missense mutation, Genetic Predisposition to Disease, Ovarian Neoplasms, medicine.disease, Pedigree, DNA-Binding Proteins, Serous fluid, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Fallopian tube cancer, RNA splicing, Cancer research, Female, Ovarian cancer, Fallopian tube
Abstract: PURPOSE: Mutations in RAD51D are associated with a predisposition to primary ovarian, fallopian tube, and peritoneal carcinoma. Beyond ovarian cancer, recent studies have also suggested that mutations in RAD51D could confer increased risk of triple negative breast cancer (TNBC). Our study aims to characterize a RAD51D missense variant in a hereditary breast and ovarian cancer (OC) family. METHODS: The effects of the RAD51D c.82G>A (p.Val28Met) variant on mRNA splicing were evaluated and characterized using RT-PCR, cloning and DNA sequencing. RESULTS: This variant completely disrupts normal splicing and results in the loss of 3’end of 5’UTR and the entire exon 1 (c.−86_c.82), which presumably leads to loss of the RAD51D protein. The RAD51D c.82G>A (p.Val28Met) variant is clinically significant and classified as likely pathogenic. CONCLUSIONS: Our results indicate that the RAD51D c.82G>A (p.Val28Met) variant contributes to cancer predisposition through disruption of normal mRNA splicing. The identification of this variant in an individual affected with high grade serous fallopian tube cancer suggests that the RAD51D variant may contribute to predisposition to the ovarian cancer in this family.
Published: 2021

47. Innovative Partnerships

Author: Joanna Cummings, Erin Bergquist, Chandavone Phoxay, Laurene Boateng, and Diane D. Stadler
Subjects: Medical education, Malnutrition, Underserved Population, Nutrition and Dietetics, Political science, medicine, Global partnership, Medical nutrition therapy, medicine.disease
Published: 2021

48. Optimized Management of Nivolumab and Ipilimumab in Advanced Renal Cell Carcinoma: A Response-Based Phase II Study (OMNIVORE)

Author: Rana R. McKay, Lauren C. Harshman, David F. McDermott, Benjamin L. Maughan, Tracy L. Rose, Christos Kyriakopoulos, Bradley Alexander McGregor, Toni K. Choueiri, Walter M. Stadler, Yousef Zakharia, David A. Braun, Xiao Wei, and Wanling Xie
Subjects: Adult, Male, Cancer Research, Phases of clinical research, Ipilimumab, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, Carcinoma, Renal Cell, Immune Checkpoint Inhibitors, Aged, business.industry, ORIGINAL REPORTS, Middle Aged, medicine.disease, Immune checkpoint, Blockade, Nivolumab, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, business, 030215 immunology, medicine.drug
Abstract: PURPOSE In this phase II response-adaptive trial, we investigated the rational application of immune checkpoint blockade in renal cell carcinoma (RCC; ClinicalTrials.gov identifier: NCT03203473 ). METHODS We enrolled patients with metastatic RCC with no prior checkpoint inhibitor exposure. All patients received nivolumab alone with subsequent arm allocation based on response. Patients with a confirmed partial response (PR) or complete response (CR) within 6 months discontinued nivolumab and were observed (arm A). Patients with stable disease or progressive disease (PD) after no more than 6 months of nivolumab received two doses of ipilimumab (arm B). The primary endpoints were the proportion of patients with PR/CR at 1 year after nivolumab discontinuation (arm A) and proportion of nivolumab nonresponders who converted to PR/CR after ipilimumab (arm B). RESULTS Overall, 83 patients initiated treatment, of whom 96% had clear-cell histology, 51% were treatment naïve, and 67% had intermediate/poor-risk disease. Median follow-up was 19.5 months. Within 6 months, induction nivolumab resulted in a confirmed PR in 12% of patients (n = 10). Fourteen patients were not allocated to a study arm (seven because of toxicity, seven because of PD). Twelve patients (14%) were allocated to arm A and discontinued nivolumab, of whom five (42%; 90% CI, 18% to 68%) remained off nivolumab at ≥ 1 year. Of 57 patients (69%) allocated to arm B, two patients converted to a confirmed PR (4%; 90% CI, 1% to 11%), and no CRs were observed. CONCLUSION In this study, nivolumab followed by two doses of ipilimumab resulted in no CRs and a low PR/CR conversion. The number of patients evaluated for nivolumab discontinuation was too small to assess the value of this approach. Currently, our data do not support a response-adaptive strategy for checkpoint blockade in advanced RCC.
Published: 2020

49. Neuroendocrine Stress Response in Female and Male Youths With Conduct Disorder and Associations With Early Adversity

Author: Christine M. Freitag, Karen D. González-Madruga, Helena Oldenhof, Christina Stadler, Molly Batchelor, Andreas G. Chiocchetti, Katharina Ackermann, Nora Maria Raschle, Leonora Vllasaliu, Graeme Fairchild, Gregor Kohls, Anka Bernhard, Anne Martinelli, Arne Popma, Kerstin Konrad, Lucres M. C. Jansen, VU University medical center, APH - Mental Health, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), University of Zurich, and Bernhard, Anka
Subjects: Conduct Disorder, Male, medicine.medical_specialty, Adolescent, Hydrocortisone, Neuropeptide, cortisol, Oxytocin, Fight-or-flight response, 2738 Psychiatry and Mental Health, SDG 3 - Good Health and Well-being, Internal medicine, oxytocin, Trier social stress test, medicine, Developmental and Educational Psychology, Humans, Testosterone, Child, Saliva, 3204 Developmental and Educational Psychology, conduct disorder, 10093 Institute of Psychology, business.industry, stress response, medicine.disease, Psychiatry and Mental health, Endocrinology, Prosocial behavior, Conduct disorder, testosterone, Female, 150 Psychology, business, Stress, Psychological, 10190 Jacobs Center for Productive Youth Development, Hormone, medicine.drug
Abstract: Objective: Conduct disorder (CD) involves aggressive and antisocial behavior and is associated with blunted cortisol stress response in male youths. Far less is known about cortisol stress responsivity in female youths with CD or other neuroendocrine responses in both sexes. Although CD is linked to early adversity, the possibility that neuroendocrine alterations may mediate the relationship between early adversity and CD has not been systematically investigated. Method: Within the European FemNAT-CD multi-site study, salivary cortisol, testosterone, the testosterone/cortisol ratio, oxytocin, and psychological stress response to a standardized psychosocial stress test (the Trier Social Stress Test [TSST]), together with common pre- and postnatal environmental risk factors, were investigated in 130 pubertal youths with CD (63% female, 9-18 years of age) and 160 sex-, age-, and puberty-matched healthy controls (HCs). Results: The TSST induced psychological stress in both CD and HCs. In contrast, female and male youths with CD showed blunted cortisol, testosterone, oxytocin, and testosterone/cortisol stress responses compared to HCs. These blunted stress responses partly mediated the relationship between environmental risk factors and CD. Conclusion: Findings from this unique sample, including many female youths with CD, provide evidence for a widespread attenuated stress responsivity of not only stress hormones, but also sex hormones and neuropeptides in CD and its subgroups (eg, with limited prosocial emotions). Results are the first to demonstrate blunted neuroendocrine stress responses in both female and male youths with CD. Early adversity may alter neuroendocrine stress responsivity. Biological mechanisms should be investigated further to pave the way for personalized intervention, thereby improving treatments for CD.
Published: 2022

50. Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Author: Serra, Eva Gonçalves, Schwerd, Tobias, Moutsianas, Loukas, Cavounidis, Athena, Fachal, Laura, Pandey, Sumeet, Kammermeier, Jochen, Croft, Nicholas M, Posovszky, Carsten, Rodrigues, Astor, Russell, Richard K, Barakat, Farah, Auth, Marcus K H, Heuschkel, Robert, Zilbauer, Matthias, Fyderek, Krzysztof, Braegger, Christian, Travis, Simon P, Satsangi, Jack, Parkes, Miles, Thapar, Nikhil, Ferry, Helen, Matte, Julie C, Gilmour, Kimberly C, Wedrychowicz, Andrzej, Sullivan, Peter, Moore, Carmel, Sambrook, Jennifer, Ouwehand, Willem, Roberts, David, Danesh, John, Baeumler, Toni A, Fulga, Tudor A, Karaminejadranjbar, Mohammad, Ahmed, Ahmed, Wilson, Rachel, Barrett, Jeffrey C, Elkadri, Abdul, Griffiths, Anne M, Snapper, Scott B, Shah, Neil, Muise, Aleixo M, Wilson, David C, Uhlig, Holm H, Anderson, Carl A, Marlen, Zurek, Caterina, Strisciuglio, Mamoun, Elawad, Bernice, Lo, Carolina, Arancibia-Carcamo, Adam, Bailey, Ellie, Barnes, Elizabeth Louise, Bird-Lieberman, Oliver, Brain, Barbara, Braden, Jane, Collier, James, East, Lucy, Howarth, Satish, Keshav, Paul, Klenerman, Simon, Leedham, Rebecca, Palmer, Fiona, Powrie, Alison, Simmons, Matthew, Walker, Zoe, Tolkien, Stephen, Kaptoge, David, Allen, Susan, Mehenny, Jonathan, Mant, Emanuele, Di Angelantonio, Simon G, Thompson, Bahtiyar, Yilmaz, Pascal, Juillerat, Markus, Geuking, Reiner, Wiest, Andrew J, Macpherson, Francisco Damian, Bravo, Lukas, Brügger, Ove, Carstens, Ulrike Graf, Bigler, Benjamin, Heimgartner, Monica, Rusticeanu, Sybille, Schmid-Uebelhart, Bruno, Strebel, Aurora, Tatu, Radu, Tutuian, Ove, Øyås, Charlotte, Ramon, Jörg, Stelling, Yannick, Franc, Nicolas, Fournier, Valerie E H, Pittet, Bernard, Burnand, Mara, Egger, Delphine, Golay, Astrid, Marot, Leilla, Musso, Valérie, Pittet, Jean-Benoît, Rossel, Vivianne, Seematter, Joachim, Sommer, Rachel, Vulliamy, Pierre, Michetti, Michel H, Maillard, Céline, Keller, Andreas, Nydegger, Alain, Schoepfe, Eva, Archanioti, Jessica, Ezri, Montserrat, Fraga, Alain, Schoepfer, Christoph, Müller, Gerhard, Rogler, Luc, Biedermann, Mirjam, Blattmann, Sabine, Burk, Barbara, Dora, Michael, Fried, Benjamin, Misselwitz, Beat, Müllhaupt, Nicole, Obialo, Daniel, Pohl, Nadia, Raschle, Michael, Scharl, Stephan, Vavricka, Roland, Von Känel, Jonas, Zeitz, Karim, Abdelrahman, Gentiana, Ademi, Jan, Borovicka, Stephan, Brand, Remus, Frei, Johannes, Haarer, Christina, Knellwolf-Grieger, Claudia, Krieger-Grübel, Patrizia, Künzler, Christa, Meyenberger, Pamela, Meyer, Nina, Röhrich, Mikael, Sawatzki, Martin, Schelling, Gian-Marco, Semadeni, Michael, Sulz, Dorothee, Zimmermann, Patrick, Aepli, Dominique H, Criblez, Cyrill, Hess, Jean-Pierre, Richterich, Johannes, Spalinger, Dominic, Staudenmann, Andreas, Stulz, Stefanie, Wöhrle, Amman, Thomas, Claudia, Anderegg, Henrik, Köhler, Rachel, Kusche, Anca-Teodora, Antonino, Eviano, Arrigoni, José M, Bengoa, Sophie, Cunningham, Philippe, de Saussure, Laurent, Girard, Diana Bakker, de Jong, Polat, Bastürk, Simon, Brunner, Lukas, Degen, Petr, Hruz, Carolina, Khalid-de Bakker, Jan, Niess, Bruno, Balsiger, Janine, Haldemann, Gaby, Saner, Frank, Seibold, Peter, Bauerfeind, Andrea, Becocci, Dominique, Belli, Janek, Binek, Peter, Hengstler, Stephan, Boehm, Tujana, Boldanov, Patrick, Bühr, Rebekka, Koller, Vanessa, Rueger, Arne, Senning, Emanuel, Burri, Sophie, Buyse, Dahlia-Thao, Cao, Fabrizia, D'Angelo, Joakim, Delarive, Christopher, Doerig, Roxane, Hessler, Claudia, Preissler, Ronald, Rentsch, Branislav, Risti, Marc Alain, Ritz, Michael, Steuerwald, Jürg, Vögtlin, Markus, Sagmeister, Bernhard, Sauter, Susanne, Schibli, Christiane, Sokollik, Hugo, Schlauri, Jean-François, Schnegg, Mariam, Seirafi, Holger, Spangenberger, Philippe, Stadler, Peter, Staub, Volker, Stenz, Michela, Tempia-Caliera, Joël, Thorens, Kaspar, Truninger, Patrick, Urfer, Francesco, Viani, Dominique, Vouillamoz, Silvan, Zander, Tina, Wyli, L, Jostins, N A, Kennedy, T, Ahmad, C A, Lamb, C, Edwards, A, Hart, C, Hawkey, J C, Mansfield, C, Mowat, W G, Newman, A, Simmons, M, Tremelling, J C, Lee, N J, Prescott, C G, Mathew, C W, Lees, D P B, McGovern, S R, Targan, G, Botwin, E, Mengesha, P, Fleshner, C, Landers, D, Li, J D, Rioux, A, Bitton, J, Côté-Daigneault, M J, Daly, R, Xavier, K, Morris, G, Boucher, J H, Cho, C, Abraham, M, Merad, B, Sands, I, Peter, K, Hao, Y, Itan, R H, Duerr, L, Konnikova, M B, Schwartz, S, Proksell, E, Johnston, V, Miladinova, W, Chen, S R, Brant, L, Datta, M S, Silverberg, L P, Schumm, S, Birch, M, Giri, K, Gettler, Y, Sharma, C, Stevens, M, Lazarev, T, Haritunians, Fachal, Laura [0000-0002-7256-9752], Croft, Nicholas M [0000-0002-1519-6435], Posovszky, Carsten [0000-0002-9487-8812], Russell, Richard K [0000-0001-7398-4926], Zilbauer, Matthias [0000-0002-7272-0547], Travis, Simon P [0000-0002-2690-4361], Matte, Julie C [0000-0001-5642-648X], Wedrychowicz, Andrzej [0000-0003-1448-167X], Fulga, Tudor A [0000-0002-1056-0082], Karaminejadranjbar, Mohammad [0000-0002-7770-2065], Ahmed, Ahmed [0000-0001-6509-2581], Muise, Aleixo M [0000-0001-9624-3346], Wilson, David C [0000-0003-0879-1129], Apollo - University of Cambridge Repository, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Croft, Nicholas M. [0000-0002-1519-6435], Russell, Richard K. [0000-0001-7398-4926], Travis, Simon P. [0000-0002-2690-4361], Matte, Julie C. [0000-0001-5642-648X], Fulga, Tudor A. [0000-0002-1056-0082], Muise, Aleixo M. [0000-0001-9624-3346], Wilson, David C. [0000-0003-0879-1129], Eva Gonçalves, Serra, Tobias, Schwerd, Loukas, Moutsiana, Athena, Cavounidi, Laura, Fachal, Sumeet, Pandey, Jochen, Kammermeier, Nicholas M, Croft, Carsten, Posovszky, Astor, Rodrigue, Richard K, Russell, Farah, Barakat, Marcus K H, Auth, Robert, Heuschkel, Matthias, Zilbauer, Krzysztof, Fyderek, Christian, Braegger, Simon P, Travi, Jack, Satsangi, Miles, Parke, Nikhil, Thapar, Helen, Ferry, Julie C, Matte, Kimberly C, Gilmour, Andrzej, Wedrychowicz, Peter, Sullivan, Carmel, Moore, Jennifer, Sambrook, Willem, Ouwehand, David, Robert, John, Danesh, Toni A, Baeumler, Tudor A, Fulga, Mohammad, Karaminejadranjbar, Ahmed, Ahmed, Rachel, Wilson, Jeffrey C, Barrett, Abdul, Elkadri, Anne M, Griffith, Scott B, Snapper, Neil, Shah, Aleixo M, Muise, David C, Wilson, Holm H, Uhlig, Carl A, Anderson, Zurek, Marlen, Strisciuglio, Caterina, Elawad, Mamoun, Lo, Bernice, Arancibia-Carcamo, Carolina, Bailey, Adam, Barnes, Ellie, Bird-Lieberman, Elizabeth Louise, Brain, Oliver, Braden, Barbara, Collier, Jane, East, Jame, Howarth, Lucy, Keshav, Satish, Klenerman, Paul, Leedham, Simon, Palmer, Rebecca, Powrie, Fiona, Simmons, Alison, Walker, Matthew, Tolkien, Zoe, Kaptoge, Stephen, Allen, David, Mehenny, Susan, Mant, Jonathan, Di Angelantonio, Emanuele, Thompson, Simon G, Yilmaz, Bahtiyar, Juillerat, Pascal, Geuking, Marku, Wiest, Reiner, Macpherson, Andrew J, Bravo, Francisco Damian, Brügger, Luka, Carstens, Ove, Bigler, Ulrike Graf, Heimgartner, Benjamin, Rusticeanu, Monica, Schmid-Uebelhart, Sybille, Strebel, Bruno, Tatu, Aurora, Tutuian, Radu, Øyås, Ove, Ramon, Charlotte, Stelling, Jörg, Franc, Yannick, Fournier, Nicola, Pittet, Valerie E H, Burnand, Bernard, Egger, Mara, Golay, Delphine, Marot, Astrid, Musso, Leilla, Pittet, Valérie, Rossel, Jean-Benoît, Seematter, Vivianne, Sommer, Joachim, Vulliamy, Rachel, Michetti, Pierre, Maillard, Michel H, Keller, Céline, Nydegger, Andrea, Schoepfe, Alain, Archanioti, Eva, Ezri, Jessica, Fraga, Montserrat, Schoepfer, Alain, Müller, Christoph, Rogler, Gerhard, Biedermann, Luc, Blattmann, Mirjam, Burk, Sabine, Dora, Barbara, Fried, Michael, Misselwitz, Benjamin, Müllhaupt, Beat, Obialo, Nicole, Pohl, Daniel, Raschle, Nadia, Scharl, Michael, Vavricka, Stephan, Von Känel, Roland, Zeitz, Jona, Abdelrahman, Karim, Ademi, Gentiana, Borovicka, Jan, Brand, Stephan, Frei, Remu, Haarer, Johanne, Knellwolf-Grieger, Christina, Krieger-Grübel, Claudia, Künzler, Patrizia, Meyenberger, Christa, Meyer, Pamela, Röhrich, Nina, Sawatzki, Mikael, Schelling, Martin, Semadeni, Gian-Marco, Sulz, Michael, Zimmermann, Dorothee, Aepli, Patrick, Criblez, Dominique H, Hess, Cyrill, Richterich, Jean-Pierre, Spalinger, Johanne, Staudenmann, Dominic, Stulz, Andrea, Wöhrle, Stefanie, Thomas, Amman, Anderegg, Claudia, Köhler, Henrik, Kusche, Rachel, Antonino, Anca-Teodora, Arrigoni, Eviano, Bengoa, José M, Cunningham, Sophie, de Saussure, Philippe, Girard, Laurent, de Jong, Diana Bakker, Bastürk, Polat, Brunner, Simon, Degen, Luka, Hruz, Petr, Khalid-de Bakker, Carolina, Niess, Jan, Balsiger, Bruno, Haldemann, Janine, Saner, Gaby, Seibold, Frank, Bauerfeind, Peter, Becocci, Andrea, Belli, Dominique, Binek, Janek, Hengstler, Peter, Boehm, Stephan, Boldanov, Tujana, Bühr, Patrick, Koller, Rebekka, Rueger, Vanessa, Senning, Arne, Burri, Emanuel, Buyse, Sophie, Cao, Dahlia-Thao, D'Angelo, Fabrizia, Delarive, Joakim, Doerig, Christopher, Hessler, Roxane, Preissler, Claudia, Rentsch, Ronald, Risti, Branislav, Ritz, Marc Alain, Steuerwald, Michael, Vögtlin, Jürg, Sagmeister, Marku, Sauter, Bernhard, Schibli, Susanne, Sokollik, Christiane, Schlauri, Hugo, Schnegg, Jean-Françoi, Seirafi, Mariam, Spangenberger, Holger, Stadler, Philippe, Staub, Peter, Stenz, Volker, Tempia-Caliera, Michela, Thorens, Joël, Truninger, Kaspar, Urfer, Patrick, Viani, Francesco, Vouillamoz, Dominique, Zander, Silvan, Wyli, Tina, Jostins, L, Kennedy, N A, Ahmad, T, Lamb, C A, Edwards, C, Hart, A, Hawkey, C, Mansfield, J C, Mowat, C, Newman, W G, Simmons, A, Tremelling, M, Lee, J C, Prescott, N J, Mathew, C G, Lees, C W, Mcgovern, D P B, Targan, S R, Botwin, G, Mengesha, E, Fleshner, P, Landers, C, Li, D, Rioux, J D, Bitton, A, Côté-Daigneault, J, Daly, M J, Xavier, R, Morris, K, Boucher, G, Cho, J H, Abraham, C, Merad, M, Sands, B, Peter, I, Hao, K, Itan, Y, Duerr, R H, Konnikova, L, Schwartz, M B, Proksell, S, Johnston, E, Miladinova, V, Chen, W, Brant, S R, Datta, L, Silverberg, M S, Schumm, L P, Birch, S, Giri, M, Gettler, K, Sharma, Y, Stevens, C, Lazarev, M, Haritunians, T, Carrami, Eli M [0000-0002-7770-2065], COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Zurek, M., Strisciuglio, C., Elawad, M., Lo, B., Arancibia-Carcamo, C., Bailey, A., Barnes, E., Bird-Lieberman, E.L., Brain, O., Braden, B., Collier, J., East, J., Howarth, L., Keshav, S., Klenerman, P., Leedham, S., Palmer, R., Powrie, F., Simmons, A., Walker, M., Tolkien, Z., Kaptoge, S., Allen, D., Mehenny, S., Mant, J., Di Angelantonio, E., Thompson, S.G., Yilmaz, B., Juillerat, P., Geuking, M., Wiest, R., Macpherson, A.J., Bravo, F.D., Brügger, L., Carstens, O., Bigler, U.G., Heimgartner, B., Rusticeanu, M., Schmid-Uebelhart, S., Strebel, B., Tatu, A., Tutuian, R., Øyås, O., Ramon, C., Stelling, J., Franc, Y., Fournier, N., Pittet, VEH, Burnand, B., Egger, M., Golay, D., Marot, A., Musso, L., Pittet, V., Rossel, J.B., Seematter, V., Sommer, J., Vulliamy, R., Michetti, P., Maillard, M.H., Keller, C., Nydegger, A., Schoepfe, A., Archanioti, E., Ezri, J., Fraga, M., Schoepfer, A., Müller, C., Rogler, G., Biedermann, L., Blattmann, M., Burk, S., Dora, B., Fried, M., Misselwitz, B., Müllhaupt, B., Obialo, N., Pohl, D., Raschle, N., Scharl, M., Vavricka, S., Von Känel, R., Zeitz, J., Abdelrahman, K., Ademi, G., Borovicka, J., Brand, S., Frei, R., Haarer, J., Knellwolf-Grieger, C., Krieger-Grübel, C., Künzler, P., Meyenberger, C., Meyer, P., Röhrich, N., Sawatzki, M., Schelling, M., Semadeni, G.M., Sulz, M., Zimmermann, D., Aepli, P., Criblez, D.H., Hess, C., Richterich, J.P., Spalinger, J., Staudenmann, D., Stulz, A., Wöhrle, S., Thomas, A., Anderegg, C., Köhler, H., Kusche, R., Antonino, A.T., Arrigoni, E., Bengoa, J.M., Cunningham, S., de Saussure, P., Girard, L., de Jong, D.B., Bastürk, P., Brunner, S., Degen, L., Hruz, P., Bakker, C.K., Niess, J., Balsiger, B., Haldemann, J., Saner, G., Seibold, F., Bauerfeind, P., Becocci, A., Belli, D., Binek, J., Hengstler, P., Boehm, S., Boldanov, T., Bühr, P., Koller, R., Rueger, V., Senning, A., Burri, E., Buyse, S., Cao, D.T., D'Angelo, F., Delarive, J., Doerig, C., Hessler, R., Preissler, C., Rentsch, R., Risti, B., Ritz, M.A., Steuerwald, M., Vögtlin, J., Sagmeister, M., Sauter, B., Schibli, S., Sokollik, C., Schlauri, H., Schnegg, J.F., Seirafi, M., Spangenberger, H., Stadler, P., Staub, P., Stenz, V., Tempia-Caliera, M., Thorens, J., Truninger, K., Urfer, P., Viani, F., Vouillamoz, D., Zander, S., Wyli, T., Jostins, L., Kennedy, N.A., Ahmad, T., Lamb, C.A., Edwards, C., Hart, A., Hawkey, C., Mansfield, J.C., Mowat, C., Newman, W.G., Tremelling, M., Lee, J.C., Prescott, N.J., Mathew, C.G., Lees, C.W., McGovern, DPB, Targan, S.R., Botwin, G., Mengesha, E., Fleshner, P., Landers, C., Li, D., Rioux, J.D., Bitton, A., Côté-Daigneault, J., Daly, M.J., Xavier, R., Morris, K., Boucher, G., Cho, J.H., Abraham, C., Merad, M., Sands, B., Peter, I., Hao, K., Itan, Y., Duerr, R.H., Konnikova, L., Schwartz, M.B., Proksell, S., Johnston, E., Miladinova, V., Chen, W., Brant, S.R., Datta, L., Silverberg, M.S., Schumm, L.P., Birch, S., Giri, M., Gettler, K., Sharma, Y., Stevens, C., Lazarev, M., and Haritunians, T.
Subjects: 0301 basic medicine, Male, Multifactorial Inheritance, General Physics and Astronomy, 631/208/1516, 13, Inflammatory bowel disease, Whole Exome Sequencing, Adult, Age of Onset, Case-Control Studies, Child, Child, Preschool, Cohort Studies, Female, Genes, Recessive, Genetic Predisposition to Disease, Genetic Variation, Humans, Infant, Infant, Newborn, Inflammatory Bowel Diseases/etiology, Inflammatory Bowel Diseases/genetics, Loss of Function Mutation, Mosaicism, Mutation, NADPH Oxidase 2/genetics, Pedigree, Primary Immunodeficiency Diseases/complications, Primary Immunodeficiency Diseases/genetics, Risk Factors, 0302 clinical medicine, Primary Immunodeficiency Disease, Medicine, lcsh:Science, Exome sequencing, 49/31, education.field_of_study, Multidisciplinary, Medical genetics, article, 692/699/249/1570, 631/250/249/2510/257, 631/208/248, 3. Good health, NADPH Oxidase 2, 030211 gastroenterology & hepatology, Case-Control Studie, Human, medicine.medical_specialty, Science, Primary Immunodeficiency Diseases, Population, 45/22, 45/23, digestive system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immunological deficiency syndromes, Exome Sequencing, Immunogenetics, Allele, education, 45, business.industry, Risk Factor, Inflammatory Bowel Disease, Case-control study, General Chemistry, medicine.disease, Inflammatory Bowel Diseases, digestive system diseases, 49, 030104 developmental biology, Immunology, Primary immunodeficiency, lcsh:Q, Age of onset, Cohort Studie, business
Abstract: Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients (median age-at-diagnosis of 3.5 years), in whom no Mendelian disorders were clinically suspected. In five patients we detect a primary immunodeficiency or enteropathy, with clinical consequences (XIAP, CYBA, SH2D1A, PCSK1). We also present a case study of a VEO-IBD patient with a mosaic de novo, pathogenic allele in CYBB. The mutation is present in ~70% of phagocytes and sufficient to result in defective bacterial handling but not life-threatening infections. Finally, we show that VEO-IBD patients have, on average, higher IBD polygenic risk scores than population controls (99 patients and 18,780 controls; P, Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.
Published: 2020

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