1. Updated Imaging Findings in Congenital Zika Syndrome
- Author
-
Vanessa van der Linden, Paul M. Parizel, Marcelo Moraes Valença, Natacha Calheiros de Lima Petribu, Carlos Alexandre Antunes de Brito, and Maria de Fátima Viana Vasco Aragão
- Subjects
Diagnostic Imaging ,Disease ,Nervous System Malformations ,Ultrasonography, Prenatal ,030218 nuclear medicine & medical imaging ,Zika virus ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Polymicrogyria ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Pregnancy Complications, Infectious ,biology ,medicine.diagnostic_test ,Zika Virus Infection ,business.industry ,Pachygyria ,Infant, Newborn ,Brain ,Calcinosis ,Infant ,Magnetic resonance imaging ,Syndrome ,Zika Virus ,Anatomy ,biology.organism_classification ,medicine.disease ,Magnetic Resonance Imaging ,Simplified gyral pattern ,Microcephaly ,Female ,Tomography, X-Ray Computed ,business ,030217 neurology & neurosurgery ,Hydrocephalus - Abstract
In congenital Zika virus syndrome (CZS), the most frequent radiological findings are calcifications in the cortical-white matter junction and malformations of cortical development (pachygyria or polymicrogyria, which occur predominantly in the frontal lobes, or a simplified gyral pattern), ventriculomegaly, enlargement of the cisterna magna and the extra-axial subarachnoid space, corpus callosum abnormalities, and reduced brain volume. This syndrome can also result in a decrease in the brainstem and cerebellum volumes and delayed myelination. Infants with CZS may show venous thrombosis and lenticulostriate vasculopathies. Over a 3-year follow-up period, many infants with CZS showed hydrocephalus, reduction in brain calcifications, and greater reduction in brain thickness.
- Published
- 2019