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1. Centella Asiatica (GOTU KOLA) TREATMENT ATTENUATES PRO-INFLAMMATORY MEDIATORS IN LIVER OF RATS WITH ELECTRICAL FOOT SHOCK STRESS MODEL

Author: Mawaddah Ar Rochmah, Muhammad Mansyur Romi, Dwi Cahyani Ratna Sari, Rizky Nur Mainichi, Ratih Kemalasari, Nur Arfian, Gita Mumtarin Dara, and Wiwit Ananda Wahyu Setyaningsih
Subjects: Liver injury, Chemokine, Centella, biology, business.industry, Pharmacology, biology.organism_classification, medicine.disease, Reverse transcription polymerase chain reaction, Mediator, Complementary and alternative medicine, Apoptosis, Drug Discovery, biology.protein, Medicine, Secretion, business, Receptor
Abstract: Background: Stress induces secretion of cathecolamines and glucocorticoids, which may produce liver injury. Followed by the production of inflammatory mediators, it causes apoptosis. Centella asiatica (CeA) has anti-inflammatory and hepatoprotective effects. The present study aims to determine the role of CeA in the attenuation of liver pro-inflammatory mediator expression in rats with electrical foot shock stress model. Materials and Methods: Twenty-four Sprague-Dawley rats were randomized into four groups consisted of six rats each: (1) Control group, (2) CeA-treated group, (3) Stress group, and (4) CeA + stress group. Reverse transcriptase PCR of inflammatory and apoptosis markers as well as Real-Time PCR of β2-adrenergic receptor were performed from liver tissues. Results: Electrical foot shock stress induced up-regulation of NFκB and TNF-α mRNA expressions as pro-inflammatory mediators, compared to control group. This alteration was followed by up-regulation of BAX and β2-adrenergic receptor, as well as the down-regulation of BCl2 compared to control. CeA treatment prevented enhancement of NFκB, TNF-α, TLR-4 and β-adrenergic receptor mRNA expressions, which was followed by down-regulation of BAX and up-regulation of BCl-2, compared to stress group. Conclusion: CeA prevents secretion of pro-inflammatory chemokines and cytokines as well as apoptotic markers in liver cells through the activation of β2-adrenergic receptor.
Published: 2023
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2. Analisis Hubungan Perilaku Merokok dengan Obesitas Sentral Pada Orang Dewasa Sehat di Suradadi Kabupaten Tegal

Author: Eva Novita Sari, Ratih Sakti Prastiwi, and Agus Susanto
Subjects: Research design, Waist, central obesity, business.industry, medicine.disease, healthy adult, Obesity, smoking behavior, Stratified sampling, Smoking behavior, Sample size determination, Environmental health, medicine, Observational study, Public Health, business, Socioeconomic status
Abstract: Central obesity is influenced by many factors such as changes in age, gender, economic status, life habits including lack of physical activity, low fiber consumption, consumption of simple carbohydrates, consumption of fatty foods, and smoking behavior. Smoking behavior is thought to be a significant factor in forming central obesity in adult males. The purpose of this study was to determine the relationship between smoking behavior and central obesity in healthy adults. This study used an analytic observational design with a cross-sectional research design. The research was conducted in Suradadi Village, Suradadi District, Tegal Regency. Sampling was carried out by stratified sampling in November 2020 – January 2021. The sample size was 90 men aged 25-60 years. Data were collected by measuring the waist circumference of the respondents and recording other personal data such as age, occupation, and smoking status. Data processing is done descriptively and cross-tabulation. Testing the relationship between smoking behavior and obesity was carried out using the chi-square statistical test with the help of the SPSS version 22 application. The majority of respondents in this study had a smoking status of 68.9% and did not have central obesity 64.4%. The results of the test of the relationship between smoking status and central obesity got a p-value of 0.813. There is no significant relationship between smoking status and central obesity.
Published: 2023

3. The Value of Preoperative Plasma VEGF Levels in Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy

Author: Hadi Mostafaei, Pawel Rajwa, Francesco Soria, Péter Nyirády, Frederik König, Pierre I. Karakiewicz, Shahrokh F. Shariat, Douglas S. Scherr, Satoshi Katayama, Yair Lotan, Benjamin Pradere, Shin Egawa, Keiichiro Mori, Nico C. Grossmann, Abdulmajeed Aydh, Fahad Quhal, Jeremy Yuen-Chun Teoh, Reza Sari Motlagh, Martin Haydter, Eva Compérat, Victor M. Schuettfort, Ekaterina Laukhtina, and Marco Moschini
Subjects: Vascular Endothelial Growth Factor A, Oncology, Carcinoma, Transitional Cell, medicine.medical_specialty, Chemotherapy, Bladder cancer, Proportional hazards model, Angiogenesis, business.industry, Urology, medicine.medical_treatment, Urinary Bladder, Cystectomy, medicine.disease, Vascular endothelial growth factor, chemistry.chemical_compound, Urinary Bladder Neoplasms, chemistry, Internal medicine, medicine, Humans, Biomarker (medicine), business, Pathological
Abstract: BACKGROUND Elevated preoperative plasma levels of the angiogenesis-related marker VEGF have been associated with worse oncological outcomes in various malignancies. OBJECTIVE To investigate the predictive/prognostic role of VEGF in patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC). DESIGN, SETTING, AND PARTICIPANTS VEGF plasma levels were measured preoperatively in 1036 patients with UCB who underwent RC. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS The correlation between plasma VEGF levels and pathological and survival outcomes was assessed using logistic regression and Cox regression analyses. Discrimination was assessed using the concordance index (C index). The clinical net benefit was evaluated using decision curve analysis (DCA). RESULTS AND LIMITATIONS Patients with higher pretreatment plasma VEGF levels had poorer recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) according to log-rank tests (all p 0.05). Preoperative plasma VEGF levels were independently associated with RFS, CSS, and OS in preoperative and postoperative multivariable models. However, in all cases the C index increased by
Published: 2022
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4. Postoperative Ovarian Morphology on Ultrasound after Ovarian Torsion—Effect of Immediate Surgery: A Retrospective Cohort Study

Author: Sari Kives, Dana Elborno, Lisa Allen, and Niamh C Murphy
Subjects: Torsion Abnormality, medicine.medical_specialty, Ovarian surgery, Adolescent, Ovarian Torsion, endocrine system diseases, medicine.medical_treatment, Ovary, Cystectomy, Statistical significance, medicine, Humans, Ovarian Diseases, Child, Retrospective Studies, Ultrasonography, business.industry, Ultrasound, Ovarian torsion, Obstetrics and Gynecology, Retrospective cohort study, General Medicine, medicine.disease, Surgery, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Ovarian morphology, Female, business
Abstract: Study Objective Our objective was to determine if ovarian surgery at the time of ovarian detorsion is associated with impaired short-term ovarian function, as indicated by ovarian morphology on ultrasound when compared to detorsion alone. Design Retrospective cohort study Setting The Hospital for Sick Children, Toronto Participants Confirmed ovarian torsion in patients ≤ 18 years from 1/1/2004 to 31/12/2018 with ovarian sparing surgery. Main Outcome Measures Data was collected on demographics, procedure, intraoperative findings and post-operative ultrasound. To determine ovarian function, we compared morphology on post-operative ultrasound between those with surgery to the ovary compared to those without surgery to the ovary at the time of detorsion. We also compared ovarian volume of affected and contralateral ovaries after detorsion and surgery to the affected ovary. Results 119 patients met inclusion criteria- 67 (56%) had detorsion with surgery to the ovary and 52 (44%) had detorsion alone. There was no statistically significant difference in appearance on post-operative ultrasound between these groups (p=0.446). There was also no statistically significant difference on post-operative ultrasound of affected and contralateral ovarian volumes after detorsion and surgery to the affected ovary (p=0.69). Patients that underwent surgery to the ovary experienced a lower rate of recurrence, however, this did not reach statistical significance with a p-value of 0.080. Conclusion Our study demonstrates that surgery e.g. cystectomy to the ovary at the time of ovarian detorsion does not appear to impact ovarian function when compared to detorsion alone, as indicated on postoperative imaging. There was also no difference in volume of the affected and contralateral ovaries in those cases that underwent surgery at the time of initial detorsion. This evidence would support that immediate cystectomy at the time of initial ovarian detorsion is not associated with impaired ovarian function thus avoiding the need for an interval cystectomy.
Published: 2022
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5. Accuracy and Clinical Utility of a Tumor Grade- and Stage-based Predictive Model in Localized Upper Tract Urothelial Carcinoma

Author: Jeremy Yuen-Chun Teoh, Morgan Rouprêt, Hadi Mostafaei, Pierre I. Karakiewicz, Pawel Rajwa, Victor M. Schuettfort, Yasutomo Nasu, Reza Sari Motlagh, Marco Moschini, Nico C. Grossmann, Keiichiro Mori, Eva Compérat, Satoshi Katayama, Mohammad Abufaraj, Ekaterina Laukhtina, Motoo Araki, Dmitry Enikeev, Shahrokh F. Shariat, Fahad Quhal, Vitaly Margulis, and Benjamin Pradere
Subjects: Oncology, medicine.medical_specialty, Urology, 030232 urology & nephrology, Disease, Logistic regression, Nephroureterectomy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biopsy, medicine, Humans, Stage (cooking), Upper urinary tract, Carcinoma, Transitional Cell, medicine.diagnostic_test, business.industry, Medical record, Cancer, medicine.disease, Kidney Neoplasms, Urinary Bladder Neoplasms, Upper tract, 030220 oncology & carcinogenesis, Urothelium, business, Carcinoma in Situ
Abstract: Background Among various clinicopathologic factors used to identify low-risk upper tract urothelial carcinoma (UTUC), tumor grade and stage are of utmost importance. The clinical value added by inclusion of other risk factors remains unproven. Objective To assess the performance of a tumor grade- and stage-based (GS) model to identify patients with UTUC for whom kidney-sparing surgery (KSS) could be attempted. Design, setting, and participants In this international study, we reviewed the medical records of 1240 patients with UTUC who underwent radical nephroureterectomy. Complete data needed for risk stratification according to the European Association of Urology (EAU) and National Comprehensive Cancer Network (NCCN) guidelines were available for 560 patients. Outcome measurements and statistical analysis Univariable and multivariable logistic regression analyses were performed to determine if risk factors were associated with the presence of localized UTUC. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the GS, EAU, and NCCN models in predicting pathologic stage were calculated. Results and limitations Overall, 198 patients (35%) had clinically low-grade, noninvasive tumors, and 283 (51%) had ≤pT1disease. On multivariable analyses, none of the EAU and NCCN risk factors were associated with the presence of non–muscle-invasive UTUC among patients with low-grade and low-stage UTUC. The GS model exhibited the highest accuracy, sensitivity, and negative predictive value among all three models. According to the GS, EAU, and NCCN models, the proportion of patients eligible for KSS was 35%, 6%, and 4%, respectively. Decision curve analysis revealed that the net benefit of the three models was similar within the clinically reasonable range of probability thresholds. Conclusions The GS model showed favorable predictive accuracy and identified a greater number of KSS-eligible patients than the EAU and NCCN models. A decision-making algorithm that weighs the benefits of avoiding unnecessary kidney loss against the risk of undertreatment in case of advanced carcinoma is necessary for individualized treatment for UTUC patients. Patient summary We assessed the ability of three models to predict low-grade, low-stage disease in patients with cancer of the upper urinary tract. No risk factors other than grade assessed on biopsy and stage assessed from scans were associated with better prediction of localized cancer. A model based on grade and stage may help to identify patients who could benefit from kidney-sparing treatment of their cancer.
Published: 2022
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6. The Pattern of Peroxisome Proliferator-activated Receptor Gamma Coactivator 1-alpha Gene Expression in Type-2 Diabetes Mellitus Rat Model Liver: Focus on Exercise

Author: Novita Sari Harahap, Dharma Lindarto, Yetty Machrina, and Yunita Sari Pane
Subjects: 0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, business.industry, Peroxisome proliferator-activated receptor, Type 2 Diabetes Mellitus, General Medicine, Carbohydrate metabolism, medicine.disease, Streptozotocin, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Diabetes mellitus, Internal medicine, Coactivator, Gene expression, Exercise intensity, Medicine, business, medicine.drug
Abstract: BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) has an important role in mitochondria biogenesis which generated cellular metabolism. Carbohydrate metabolism in the liver is crucial to maintain plasma blood glucose. AIM: This research aimed to determine the expression of PGC-1α gene in the liver type-2 diabetes mellitus (T2DM) rat model, after treatment with a focus on exercise. METHODS: We used 25 healthy male Wistar rats as subjects. Rats were modified to T2DM models by feeding a high-fat diet and low-dose streptozotocin injection. We divided the rats into five groups, that is, sedentary group as a control and four others as treatment groups. The exercise was assigned for treatment groups by a run on the treadmill as moderate intensity continuous (MIC), highintensity continuous (HIC), slow interval (SI), and fast interval (FI). The treatment groups were exercise throughout 8 weeks with a frequency of 3 times a week. RESULTS: The results showed that expression of PGC-1α gene was lower in all treatment groups compared to controls (p < 0.05). Expression in HIC was higher than MIC (p < 0.05), so was the expression in FI more than SI (p < 0.05). CONCLUSIONS: Exercise affected PGC-1α gene expression in the liver of the T2DM rat model. The expression of PGC-1α was linear with exercise intensity.
Published: 2021
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7. Health Education Mentoring on Sadar Seimbang Nutrisi (SSN) and The Dangers of Anemia through Student Empowerment Movements with Examination of Hematology (Hemoglobin Hematocrit) in Vocational High School and Junior High School AsSyarief Garut for Mountainous Area Community

Author: Rekha Rahmanilah, Wika Puspika Sari, Retno Anesti, Alya Nurhaliza, and Sitti Syabariyah
Subjects: medicine.medical_specialty, Hemoglobin hematocrit, Anemia, business.industry, media_common.quotation_subject, Prevalence, Nutritional status, General Medicine, medicine.disease, Malnutrition, hemic and lymphatic diseases, Vocational education, Family medicine, medicine, Health education, Empowerment, business, media_common
Abstract: Anemia in adolescent girls still shows a high prevalence rate. The prevalence of anemia in Indonesia at the age of 5-14 is 26.4%, 18.4% of patients aged 15-24 years, and women have a high risk of anemia, especially in adolescent girls. Adolescent girls with anemia will have changed the menstrual cycle. The importance of learning adolescent nutritional status will be strategic planning for decreased nutritional macro and micro deficiencies in women. This community dedication aimed to present information about the risk of anemia through student empowerment and hematological examination (hemoglobin-hematocrit). A piece of good and proper knowledge about balanced Nutrition is an essential point of anemia prevention in adolescents.
Published: 2022
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8. Fertility and Pregnancy Outcomes After Robotic-assisted Laparoscopic Myomectomy in a Canadian Cohort

Author: Humna Amjad, Carmen McCaffrey, Hanna R. Goldberg, and Sari Kives
Subjects: medicine.medical_specialty, media_common.quotation_subject, Fertility, Robotic Surgical Procedures, Obstetrics and gynaecology, Pregnancy, Uterine Myomectomy, medicine, Humans, Prospective Studies, Fertility preservation, Prospective cohort study, Retrospective Studies, media_common, Ontario, Obstetrics, business.industry, Pregnancy Outcome, Obstetrics and Gynecology, Myoma, medicine.disease, Pregnancy rate, Uterine Neoplasms, Cohort, Female, Laparoscopy, business
Abstract: Study Objective Myomectomy is the gold standard treatment for patients with symptomatic fibroids who desire fertility preservation. Given the relatively recent application of robotic surgery in the field of gynecology, there is only a small amount of data describing fertility outcomes after robotic-assisted laparoscopic myomectomy (RALM). The objective of this study was to determine the pregnancy rate in patients trying to conceive after RALM. Design A single-center, retrospective case series. Setting Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, Ontario, Canada. Patients All patients who underwent RALM between October 2008 and September 2015 and who consented to a telephone interview were included. Intervention None. The primary outcome was pregnancy rate after RALM. Secondary outcomes included whether patients underwent fertility treatment, rate of live births after RALM, rate of spontaneous abortion mode of delivery in pregnancies following RALM, obstetric complications, and symptoms experienced postoperatively. Measurements and Main Results A total of 123 patients underwent RALM between 2008 and 2015. Of them, 101 consented to be interviewed. Average age ± standard deviation was 34.4 ± 4.4 years. Average myoma size was 8.9 ± 2.2 cm. Of all myomas, 64 (63.4%) were intramural, 35 (34.7%) were subserosal, and 2 (2%) were submucosal according to preoperative imaging. The pregnancy rate after RALM was 42/60 (70.0%). Three additional patients became pregnant who were not trying to conceive. Of the 45 patients who became pregnant, 38 (84.4%) successfully delivered or were pregnant at the time of data collection. Conclusion The pregnancy rate after RALM was 70.0%, which is similar to that reported in previous studies. Future research should aim to conduct larger, prospective studies investigating fertility outcomes after RALM and should aim to identify variables that predict pregnancy.
Published: 2022
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9. Evaluation of oxidative stress, 3-Nitrotyrosine, and HMGB-1 levels in patients with wet type Age-Related Macular Degeneration

Author: Inayet Gunturk, Gamze Yıldırım, Serpil Erşan, Kürşad Ramazan Zor, Ismail Sari, Gönül Şeyda Seydel, and Erkut Küçük
Subjects: medicine.medical_specialty, business.industry, Biochemistry (medical), Clinical Biochemistry, Macular degeneration, medicine.disease_cause, medicine.disease, 3-nitrotyrosine, Endocrinology, Age related, Internal medicine, medicine, In patient, business, Oxidative stress
Abstract: This study aims to compare serum HMGB-1, 3-nitrotyrosine (3-NT), TAS, TOS, and OSI levels in Wettype Age-Related Macular Degeneration (wAMD) patients and healthy controls to determine the correlation of these parameters with each other.Thirty patients with Wet-type Age-Related Macular Degeneration (wAMD) and 27 healthy adults, as controls were enrolled in the study. We determined the TAS and TOS levels in serum samples of both groups using commercial kits on a microplate reader. Serum HMGB-1 and 3-NT levels were measured with the enzyme-linked immunosorbent assay method.HMGB-1 levels were significantly higher in the patient group (137.51 pg/mL, p=0.001), while there was no difference between the two groups in serum 3-NT levels (p=0.428). A statistically significant difference found in the levels of TOS and OSI (p=0.001 and p=0.045, respectively) between the patients and controls, however, no significant difference was observed between the groups in terms of TAS levels (p=0.228).Oxidative stress and HMGB-1 levels were increased in wAMD patients and enhanced oxidative stress may be associated with increased tissue necrosis and inflammation. Thus administration of antioxidant treatment in addition to routine therapy should be considered in wAMD.Ova studija ima za cilj da uporedi serumske nivoe HMBG-1, 3-nitrotirozina (3-NT), TAS, TOS i OSI kod pacijenata sa vlažnom starosnom makularnom degeneracijom (vAMD) i zdravih kontrola kako bi se utvrdila korelacija ovih parametri međusobno.Trideset pacijenata sa vlažnom starosnom makularnom degeneracijom (wAMD) i 27 zdravih odraslih osoba su uključene u studiju. Određivali smo nivoe TAS i TOS u uzorcima seruma obe grupe pomoću komercijalnih kompleta na čitaču mikroploča. Serumski nivoi HMBG-1 i 3-NT mereni su pomoću enzimsko-imunološke analize.Nivoi HMBG-1 bili su značajno veći u grupi pacijenata (137,51 pg/mL, p = 0,001), dok nije bilo razlike između dve grupe u serumskim nivoima 3-NT (p = 0,428). Statistički značajna razlika pronađena u nivoima TOS i OSI (p = 0,001 i p = 0,045, respektivno) između pacijenata i kontrola, međutim, nije primećena značajna razlika između grupa u pogledu nivoa TAS (p = 0,228).Oksidativni stres i nivo HMBG-1 su povećani kod pacijenata sa wAMD-om, a pojačani oksidativni stres može biti povezan sa povećanom nekrozom tkiva i upalom. Stoga bi primenu antioksidativnog tretmana pored rutinske terapije trebalo razmotriti wAMD-u.
Published: 2022
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10. Association of Vaginal Maturation Index and Vaginal pH with the Most Bothersome Symptoms of Genitourinary Syndrome of Menopause

Author: Binarwan Halim, Muhammad Fg Siregar, Ichwanul Adenin, Letta Sari Lintang, Sarma N Lumbanraja, and Irwin Lamtota Lumbanraja
Subjects: Gynecology, Menopause, medicine.medical_specialty, business.industry, Genitourinary system, medicine, Obstetrics and Gynecology, business, medicine.disease, Vaginal ph
Published: 2021
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11. Treatment induced clearance of hepatitis E viruses by interferon-lambda in liver-humanized mice

Author: Gulce Sari, Zongdi Feng, Claudia E Mulders, Thomas Vanwolleghem, Gertine W. van Oord, Andre Boonstra, Jingting Zhu, Jolanda J C Kreeft-Voermans, Gastroenterology & Hepatology, and Virology
Subjects: Alpha interferon, medicine.disease_cause, Antiviral Agents, Mice, Hepatitis E virus, SDG 3 - Good Health and Well-being, In vivo, Interferon, medicine, Animals, Humans, Potency, Receptors, Interferon, Innate immune system, Hepatology, business.industry, Interferon-alpha, medicine.disease, Hepatitis E, Immunology, Human medicine, Viral hepatitis, business, medicine.drug
Abstract: Background: Hepatitis E viruses (HEV) are an underestimated global cause of enterically transmitted viral hepatitis, which may persist in immunocompromised hosts, posing a risk for progressive liver fibrosis with limited treatment options. We previously established liver-humanized mice as a model for chronic HEV infections, which can be cleared by a 2-week pegylated (peg)-Interferon(IFN)α treatment course. However, severe side effects may hamper the use of IFNα in immunocompromised transplant recipient patients. IFNλ may be a valuable alternative, as its receptor is less ubiquitously expressed. Aims: In this study, we assess the in vitro and in vivo potency of pegIFNλ to induce innate immune signalling in liver cells and to clear a persistent HEV infection in liver-humanized mice. Methods & Results: We found that human liver cells expressed the IFNλ receptor (IFNLR1) and are responsive to pegIFNλ. Treatment with pegIFNλ of liver-humanized mice persistently infected with HEV genotype 3 showed that pegIFNλ was well tolerated. Dose escalation studies showed that although HEV was not cleared at pegIFNλ doses up to 0.12 mg/kg for a maximum of 8 weeks, a dose of 0.3 mg/kg pegIFNλ treatment resulted in complete clearance of HEV antigen and HEV RNA from the liver in 8 out of 9 liver-humanized mice. Conclusions: PegIFNλ is well tolerated in mice and leads to clearance of a persistent HEV infection in liver-humanized mice.
Published: 2021

12. The Impact of a 12-Month Activity Tracker Intervention on Activity Behavior Across Body Mass Index Subgroups Among Recent Retirees: Post Hoc Analysis of a Randomized Controlled Trial

Author: Tuija Leskinen, Pasi Koski, Kristin Suorsa, Jaana Pentti, Miika Tuominen, and Sari Stenholm
Subjects: Fitness Trackers, Overweight, Body Mass Index, law.invention, Randomized controlled trial, law, Accelerometry, Post-hoc analysis, Humans, Medicine, Orthopedics and Sports Medicine, Obesity, Exercise, Aged, computer.programming_language, sed, business.industry, Activity tracker, medicine.disease, Confidence interval, medicine.symptom, business, computer, Body mass index, Demography
Abstract: Background: This study examined the effectiveness of a 12-month activity tracker-based intervention on activity behavior among recent retirees (Enhancing physical ACTivity and healthy aging among recent REtirees [REACT]) in subgroups based on body mass index. Methods: REACT trial randomized 231 participants (mean age 65.2) into intervention and control groups. Main outcomes were accelerometer-measured moderate-to-vigorous (MVPA) and light physical activity (LPA) and sedentary time (SED) measured at baseline and 3-, 6-, and 12-month follow-ups. As a post hoc analysis, the intervention effect was examined among participants with normal weight (n = 77), overweight (n = 89), and obesity (n = 61). Results: An intervention effect was observed among participants with obesity in LPA (time × group P = .045) mirrored by a similar, albeit nonsignificant, effect in SED (P = .067), but not in MVPA (P = .92). A transient increase of 41 minutes per day (95% confidence interval, 14 to 68) in LPA was observed at 6 months among the intervention group, with a concomitant decrease of 42 minutes per day (−72 to −12) in SED. However, these changes were not maintained at 12 months. No between-group differences in changes over time were observed among participants with normal or overweight. Conclusions: Activity trackers may be particularly suitable for promoting changes in LPA and SED among older adults with obesity. However, their long-term effectiveness might be limited.
Published: 2021
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13. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

Author: Maryam Sharafkhah, Emanuel Zitt, Majid Ezzati, Luxia Zhang, Young-Ho Khang, Ellina Rakhimova, Kairit Mikkel, Tiina Vlasoff, Eruke E. Egbagbe, Sidsel Graff-Iversen, Ilona Nenko, Magdalena Klimek, Mathilde Savy, Sanjib Kumar Sharma, Alfonso Siani, Luís Lopes, Vanina Bongard, Gregor Jurak, Jacqueline F. Price, Christina-Paulina Lambrinou, Maria Lc Iurilli, Rainford J. Wilks, Bontha V. Babu, Fereidoun Azizi, Harunobu Nakamura, Marialaura Bonaccio, Angela Döring, Zhenyu Zhang, Naser Ahmadi, Jolanta Słowikowska-Hilczer, Ana Paula Carlos Cândido, Clive Osmond, Thirunavukkarasu Sathish, Robert J. Adams, Themistoklis Tzotzas, Reina Engle-Stone, Atul Trivedi, Shoichiro Tsugane, Niels Møller, Jorge Bezerra, Dénes Molnár, Muhammad Fadhli Mohd Yusoff, Badreya Al-Lahou, J. Jaime Miranda, Bahram Mohajer, Sigmund A. Anderssen, Lital Keinan Boker, Eero Kajantie, Martin Gulliford, Maties Torrent, Sumit Bharadwaj, Toshiharu Ninomiya, Zbigniew Gaciong, Nayu Ikeda, Li Juan Wu, Adrian Richter, Licia Iacoviello, Marc J. Gunter, Wenbin Wei, Norsyamlina Che Abdul Rahim, Eman Aly, Ambady Ramachandran, Nils Lehmann, Soile E. Puhakka, Giovanni Veronesi, Hongsheng Bi, Eiji Oda, Jia Li Duan, Per Tynelius, José María Huerta, Janne Schurmann Tolstrup, Rodrigo M. Carrillo-Larco, Rosangela Fernandes Lucena Batista, Victoria E Soto-Rojas, Hanno Ulmer, Shukri F. Mohamed, Anthony Kafatos, Suyeon Park, Mohsen Ibrahim, Hamed Pouraram, Bin Zhou, May Soe Aung, Lars Bo Andersen, Erfan Ghasemi, René Charles Sylva, Himanshu K. Chaturvedi, Luc Dauchet, Ahmad Ali Zainuddin, Angela Chetrit, Dan Zhu, Valérie Deschamps, Ko Ko Zaw, Peter Vollenweider, Tomas Vega, Yves Martin-Prével, Mahfuzar Rahman, Dorja Vočanec, Roman Topor-Madry, Vinay Nangia, Herculina S. Kruger, Asher Fawwad, Emily Sonestedt, Elena Pahomova, Aleksander Giwercman, Elżbieta Dziankowska-Zaborszczyk, Cecilia Björkelund, Tatjana Hejgaard, Maria Puiu, Maria Benedetta Donati, Andrew Wong, Carlos P. Boissonnet, Santosh K. Bhargava, Patrick Kolsteren, Dermot O'Reilly, Bahareh Kheiri, Wolfgang Kratzer, Susanne R. de Rooij, H. Bas Bueno-de-Mesquita, Günther Fink, José R. Banegas, Michele Monroy-Valle, Drude Molbo, Mahmudur Rahman, Hynek Pikhart, Rafael N. Pichardo, Massimo Salvetti, Hui Cai, Sarah Filippi, Georg Posch, Hung-Kwan So, Yonghua Hu, Katsuyasu Kouda, Joana Carvalho, Gailute Bernotiene, Hannu Uusitalo, Thein Thein Htay, Felix Kaducu, Maigeng Zhou, Lars Ängquist, Thi Tuyet-Hanh Tran, Charles Lunogelo, Michel Joffres, Sabina Zambon, Ronald D. Gregor, Vayia Rarra, Seyed Mohammad Hashemi-Shahri, Loreto Santa Marina, Galina Obreja, Rudolf Kaaks, Aya Mostafa, Maria do Carmo Franco, Beata Gurzkowska, Chien-Jen Chen, Marie Moitry, Nizal Sarrafzadegan, Xiangjun Wang, Diego Giulliano Destro Christofaro, Imperia Brajkovich, Fangfang Chen, Francesco Panza, Ling Yang, Holly E. Syddall, Cecily Kelleher, Michael Tornaritis, Ningli Wang, Lutgarde Thijs, Marjolein Visser, Angelika Schaffrath Rosario, María José Tormo, Jostein Steene-Johannessen, Norbert Amougou, Emmanuella Magriplis, Mar Alvarez-Pedrerol, Jingli Gao, Stig E. 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Magliano, Jitendra Jonnagaddala, Konstantinos Gkiouras, Paola Nardone, Alberto Barceló, Tomi-Pekka Tuomainen, Francesco Gianfagna, Stefania Maggi, Mohammad Hossein Somi, Behrooz Hamzeh, Miquel Porta, Vesna Jureša, Alexander D. Deev, David Faeh, Antonio Bernabe-Ortiz, Sirkka Keinänen-Kiukaanniemi, Ian Hambleton, Stefan Savin, Andre Pascal Kengne, R. Krishna Kumar, Kurt Widhalm, Marco M Ferrario, Parisa Amiri, Anjani Kumar Jha, Thamara Hubler Figueiró, Jana Kratenova, Claudia M. Hormiga, Maria Tsigga, Zivka Dika, Indrapal I. Meshram, Ei Ei K. Nang, Ian Rouse, Rusidah Selamat, Paul Korrovits, Grethe S. Tell, Julie Taylor, Anabela Mota-Pinto, Paolo Vineis, Kotsedi D Monyeki, Khuong Quynh Long, Frank J Rühli, Shelly R. McFarlane, Sara Santos Sanz, Edyta Łuszczki, Maria G. Stathopoulou, Tara Coppinger, Karin De Ridder, Lucie Viet, Anna Bugge, Mehdi Yaseri, Safiah Md Yusof, Sandra C. Fuchs, Muhammad Islam, Irfan Nuhoglu, Rui Providência, Bernard Maire, Leandra Abarca-Gómez, Sinead Brophy, Maria Ruiz-Castell, Daniela Pierannunzio, Cristina Taddei, Gowri Mahasampath, Gustavo Velasquez-Melendez, Hanna Tolonen, Sudhir Kowlessur, Bagher Larijani, Laura Torres-Collado, Susi Kriemler, Ali Akbar Shayesteh, Cynthia Robitaille, Jorge Escobedo-de la Peña, Yufang Bi, Chinh Nguyen Huu, Line Tang Møllehave, Vincent Jr DeGennaro, Noor Ani Ahmad, Anar Dushpanova, Agustinus Soemantri, Susana Sans, Ionela Pascanu, Gwenaëlle Le Coroller, Inger Ariansen, Kodanda R Kanala, Gert B. M. Mensink, Abhijit Sen, Sergej M. Ostojic, Hanan F. Abdul Rahim, Hélène Delisle, Francisco J. Félix-Redondo, Yadlapalli S. Kusuma, Michael Knoflach, Moein Yoosefi, Tanja G. M. Vrijkotte, Wolfgang Ahrens, Osvaldo Santos, Bethlehem D. Solomon, Erik Lykke Mortensen, Nikhil D. 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Aounallah-Skhiri , Joana Araújo , Inger Ariansen , Tahir Aris , Raphael E Arku , Nimmathota Arlappa , Krishna K Aryal , Thor Aspelund , Felix K Assah , Maria Cecília F Assunção , May Soe Aung , Juha Auvinen , Mária Avdicová , Shina Avi , Ana Azevedo , Mohsen Azimi-Nezhad , Fereidoun Azizi , Mehrdad Azmin , Bontha V Babu , Maja Bæksgaard Jørgensen , Azli Baharudin , Suhad Bahijri , Jennifer L Baker , Nagalla Balakrishna , Mohamed Bamoshmoosh , Maciej Banach , Piotr Bandosz , José R Banegas , Joanna Baran , Barbagallo CM, Alberto Barceló , Amina Barkat , Aluisio Jd Barros , Mauro Virgílio Gomes Barros , Abdul Basit , Joao Luiz D Bastos , Iqbal Bata , Anwar M Batieha , Rosangela L Batista , Zhamilya Battakova , Assembekov Batyrbek , Louise A Baur , Robert Beaglehole , Silvia Bel-Serrat , Antonisamy Belavendra , Habiba Ben Romdhane , Judith Benedics , Mikhail Benet , Ingunn Holden Bergh , Salim Berkinbayev , Antonio Bernabe-Ortiz , Gailute Bernotiene , Heloísa Bettiol , Jorge Bezerra , Aroor Bhagyalaxmi , Sumit Bharadwaj , Santosh K Bhargava , Zulfiqar A Bhutta , Hongsheng Bi , Yufang Bi , Daniel Bia , Elysée Claude Bika Lele, Mukharram M Bikbov , Bihungum Bista , Dusko J Bjelica , Peter Bjerregaard , Espen Bjertness , Marius B Bjertness , Cecilia Björkelund , Katia V Bloch , Anneke Blokstra , Simona Bo , Martin Bobak , Lynne M Boddy , Bernhard O Boehm , Heiner Boeing , Jose G Boggia , Elena Bogova , Carlos P Boissonnet , Stig E Bojesen , Marialaura Bonaccio , Vanina Bongard , Alice Bonilla-Vargas , Matthias Bopp , Herman Borghs , Lien Braeckevelt , Lutgart Braeckman , Marjolijn Ce Bragt , Imperia Brajkovich , Francesco Branca , Juergen Breckenkamp , João Breda , Hermann Brenner , Lizzy M Brewster , Garry R Brian , Lacramioara Brinduse , Sinead Brophy , Graziella Bruno , H Bas Bueno-de-Mesquita , Anna Bugge , Marta Buoncristiano , Genc Burazeri , Con Burns , Antonio Cabrera de León , Joseph Cacciottolo , Hui Cai , Tilema Cama , Christine Cameron , José Camolas , 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Cottel , Chris Cowell , Cora L Craig , Amelia C Crampin , Ana B Crujeiras , Semánová Csilla , Alexandra M Cucu , Liufu Cui , Felipe V Cureau , Ewelina Czenczek-Lewandowska , Graziella D'Arrigo , Eleonora d'Orsi , Liliana Dacica , María Ángeles Dal Re Saavedra , Jean Dallongeville , Camilla T Damsgaard , Rachel Dankner , Thomas M Dantoft , Parasmani Dasgupta , Saeed Dastgiri , Luc Dauchet , Kairat Davletov , Guy De Backer , Dirk De Bacquer , Giovanni de Gaetano , Stefaan De Henauw , Paula Duarte de Oliveira , David De Ridder , Karin De Ridder , Susanne R de Rooij , Delphine De Smedt , Mohan Deepa , Alexander D Deev , Vincent Jr DeGennaro , Abbas Dehghan , Hélène Delisle , Francis Delpeuch , Stefaan Demarest , Elaine Dennison , Katarzyna Dereń , Valérie Deschamps , Meghnath Dhimal , Augusto F Di Castelnuovo , Juvenal Soares Dias-da-Costa , María Elena Díaz-Sánchez , Alejandro Diaz , Zivka Dika , Shirin Djalalinia , Visnja Djordjic , Ha Tp Do , Annette J Dobson , Maria Benedetta Donati , 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, Daniel Fernández-Bergés , Daniel Ferrante , Thomas Ferrao , Marika Ferrari , Marco M Ferrario , Catterina Ferreccio , Eldridge Ferrer , Jean Ferrieres , Thamara Hubler Figueiró , Anna Fijalkowska , Günther Fink , Krista Fischer , Leng Huat Foo , Maria Forsner , Heba M Fouad , Damian K Francis , Maria do Carmo Franco , Ruth Frikke-Schmidt , Guillermo Frontera , Flavio D Fuchs , Sandra C Fuchs , Isti I Fujiati , Yuki Fujita , Matsuda Fumihiko , Takuro Furusawa , Zbigniew Gaciong , Mihai Gafencu , Andrzej Galbarczyk , Henrike Galenkamp , Daniela Galeone , Myriam Galfo , Fabio Galvano , Jingli Gao , Manoli Garcia-de-la-Hera , Marta García-Solano , Dickman Gareta , Sarah P Garnett , Jean-Michel Gaspoz , Magda Gasull , Adroaldo Cesar Araujo Gaya , Anelise Reis Gaya , Andrea Gazzinelli , Ulrike Gehring , Harald Geiger , Johanna M Geleijnse , Ali Ghanbari , Erfan Ghasemi , Oana-Florentina Gheorghe-Fronea , Simona Giampaoli , Francesco Gianfagna , Tiffany K Gill , Jonathan Giovannelli , Glen Gironella , Aleksander Giwercman , Konstantinos Gkiouras , Justyna Godos , Sibel Gogen , Marcel Goldberg , Rebecca A Goldsmith , David Goltzman , Santiago F Gómez , Aleksandra Gomula , Bruna Goncalves Cordeiro da Silva , Helen Gonçalves , David A Gonzalez-Chica , Marcela Gonzalez-Gross , Margot González-Leon , Juan P González-Rivas , Clicerio González-Villalpando , María-Elena González-Villalpando , Angel R Gonzalez , Frederic Gottrand , Antonio Pedro Graça , Sidsel Graff-Iversen , Dušan Grafnetter , Aneta Grajda , Maria G Grammatikopoulou , Ronald D Gregor , Tomasz Grodzicki , Else Karin Grøholt , Anders Grøntved , Giuseppe Grosso , Gabriella Gruden , Dongfeng Gu , Emanuela Gualdi-Russo , Pilar Guallar-Castillón , Andrea Gualtieri , Elias F Gudmundsson , Vilmundur Gudnason , Ramiro Guerrero , Idris Guessous , Andre L Guimaraes , Martin C Gulliford , Johanna Gunnlaugsdottir , Marc J Gunter , Xiu-Hua Guo , Yin Guo , Prakash C Gupta , Rajeev Gupta , Oye Gureje , Beata Gurzkowska , 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Huiart , Constanta Huidumac Petrescu , Martijn Huisman , Abdullatif Husseini , Chinh Nguyen Huu , Inge Huybrechts , Nahla Hwalla , Jolanda Hyska , Licia Iacoviello , Jesús M Ibarluzea , Mohsen M Ibrahim , Norazizah Ibrahim Wong , M Arfan Ikram , Violeta Iotova , Vilma E Irazola , Takafumi Ishida , Muhammad Islam , Sheikh Mohammed Shariful Islam , Masanori Iwasaki , Jeremy M Jacobs , Hashem Y Jaddou , Tazeen Jafar , Kenneth James , Kazi M Jamil , Konrad Jamrozik , Imre Janszky , Edward Janus , Juel Jarani , Marjo-Riitta Jarvelin , Grazyna Jasienska , Ana Jelakovic , Bojan Jelakovic , Garry Jennings , Anjani Kumar Jha , Chao Qiang Jiang , Ramon O Jimenez , Karl-Heinz Jöckel , Michel Joffres , Mattias Johansson , Jari J Jokelainen , Jost B Jonas , Jitendra Jonnagaddala , Torben Jørgensen , Pradeep Joshi , Farahnaz Joukar , Dragana P Jovic , Jacek J Jóźwiak , Anne Juolevi , Gregor Jurak , Iulia Jurca Simina , Vesna Juresa , Rudolf Kaaks , Felix O Kaducu , Anthony Kafatos , Eero O Kajantie , Zhanna Kalmatayeva , Ofra Kalter-Leibovici , Yves Kameli , Freja B Kampmann , Kodanda R Kanala , Srinivasan Kannan , Efthymios Kapantais , Argyro Karakosta , Line L Kårhus , Khem B Karki , Marzieh Katibeh , Joanne Katz , Peter T Katzmarzyk , Jussi Kauhanen , Prabhdeep Kaur , Maryam Kavousi , Gyulli M Kazakbaeva , Ulrich Keil , Lital Keinan Boker , Sirkka Keinänen-Kiukaanniemi , Roya Kelishadi , Cecily Kelleher , Han Cg Kemper , Andre P Kengne , Maryam Keramati , Alina Kerimkulova , Mathilde Kersting , Timothy Key , Yousef Saleh Khader , Davood Khalili , Kay-Tee Khaw , Bahareh Kheiri , Motahareh Kheradmand , Alireza Khosravi , Ilse Msl Khouw , Ursula Kiechl-Kohlendorfer , Stefan Kiechl , Japhet Killewo , Dong Wook Kim , Hyeon Chang Kim , Jeongseon Kim , Jenny M Kindblom , Heidi Klakk , Magdalena Klimek , Jeannette Klimont , Jurate Klumbiene , Michael Knoflach , Bhawesh Koirala , Elin Kolle , Patrick Kolsteren , Jürgen König , Raija Korpelainen , Paul Korrovits , Magdalena Korzycka , 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, Yves Martin-Prevel , Rosemarie Martin , Reynaldo Martorell , Eva Martos , Katharina Maruszczak , Stefano Marventano , Luis P Mascarenhas , Shariq R Masoodi , Ellisiv B Mathiesen , Prashant Mathur , Alicia Matijasevich , Tandi E Matsha , Christina Mavrogianni , Artur Mazur , Jean Claude N Mbanya , Shelly R McFarlane , Stephen T McGarvey , Martin McKee , Stela McLachlan , Rachael M McLean , Scott B McLean , Breige A McNulty , Sounnia Mediene Benchekor , Jurate Medzioniene , Parinaz Mehdipour , Kirsten Mehlig , Amir Houshang Mehrparvar , Aline Meirhaeghe , Jørgen Meisfjord , Christa Meisinger , Ana Maria B Menezes , Geetha R Menon , Gert Bm Mensink , Maria Teresa Menzano , Alibek Mereke , Indrapal I Meshram , Andres Metspalu , Haakon E Meyer , Jie Mi , Kim F Michaelsen , Nathalie Michels , Kairit Mikkel , Karolina Milkowska , Jody C Miller , Cláudia S Minderico , G K Mini , Juan Francisco Miquel , Mohammad Reza Mirjalili , Daphne Mirkopoulou , Erkin Mirrakhimov , Marjeta 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Theodoridis , Lutgarde Thijs , Nihal Thomas , Betina H Thuesen , Lubica Tichá , Erik J Timmermans , Anne Tjonneland , Hanna K Tolonen , Janne S Tolstrup , Murat Topbas , Roman Topór-Madry , Liv Elin Torheim , María José Tormo , Michael J Tornaritis , Maties Torrent , Laura Torres-Collado , Stefania Toselli , Giota Touloumi , Pierre Traissac , Thi Tuyet-Hanh Tran , Dimitrios Trichopoulos , Antonia Trichopoulou , Oanh Th Trinh , Atul Trivedi , Lechaba Tshepo , Maria Tsigga , Shoichiro Tsugane , Azaliia M Tuliakova , Marshall K Tulloch-Reid , Fikru Tullu , Tomi-Pekka Tuomainen , Jaakko Tuomilehto , Maria L Turley , Gilad Twig , Per Tynelius , Themistoklis Tzotzas , Christophe Tzourio , Peter Ueda , Eunice Ugel , Flora Am Ukoli , Hanno Ulmer , Belgin Unal , Zhamyila Usupova , Hannu Mt Uusitalo , Nalan Uysal , Justina Vaitkeviciute , Gonzalo Valdivia , Susana Vale , Damaskini Valvi , Rob M van Dam , Johan Van der Heyden , Yvonne T van der Schouw , Koen Van Herck , Hoang Van Minh , Natasja M Van Schoor , Irene Gm van Valkengoed , Dirk Vanderschueren , Diego Vanuzzo , Anette Varbo , Gregorio Varela-Moreiras , Patricia Varona-Pérez , Senthil K Vasan , Tomas Vega , Toomas Veidebaum , Gustavo Velasquez-Melendez , Biruta Velika , Giovanni Veronesi , Wm Monique Verschuren , Cesar G Victora , Giovanni Viegi , Lucie Viet , Salvador Villalpando , Paolo Vineis , Jesus Vioque , Jyrki K Virtanen , Marjolein Visser , Sophie Visvikis-Siest , Bharathi Viswanathan , Mihaela Vladulescu , Tiina Vlasoff , Dorja Vocanec , Peter Vollenweider , Henry Völzke , Ari Voutilainen , Sari Voutilainen , Martine Vrijheid , Tanja Gm Vrijkotte , Alisha N Wade , Aline Wagner , Thomas Waldhör , Janette Walton , Elvis Oa Wambiya , Wan Mohamad Wan Bebakar , Wan Nazaimoon Wan Mohamud , Rildo de Souza Wanderley Júnior , Ming-Dong Wang , Ningli Wang , Qian Wang , Xiangjun Wang , Ya Xing Wang , Ying-Wei Wang , S Goya Wannamethee , Nicholas Wareham , Adelheid Weber , Niels Wedderkopp , Deepa Weerasekera , Daniel Weghuber , Wenbin Wei , Aneta Weres , Bo Werner , Peter H Whincup , Kurt Widhalm , Indah S Widyahening , Andrzej Wiecek , Rainford J Wilks , Johann Willeit , Peter Willeit , Julianne Williams , Tom Wilsgaard , Bogdan Wojtyniak , Roy A Wong-McClure , Andrew Wong , Jyh Eiin Wong , Tien Yin Wong , Jean Woo , Mark Woodward , Frederick C Wu , Jianfeng Wu , Li Juan Wu , Shouling Wu , Haiquan Xu , Liang Xu , Nor Azwany Yaacob , Uruwan Yamborisut , Weili Yan , Ling Yang , Xiaoguang Yang , Yang Yang , Nazan Yardim , Mehdi Yaseri , Tabara Yasuharu , Xingwang Ye , Panayiotis K Yiallouros , Moein Yoosefi , Akihiro Yoshihara , Qi Sheng You , San-Lin You , Novie O Younger-Coleman , Safiah Md Yusof , Ahmad Faudzi Yusoff , Luciana Zaccagni , Vassilis Zafiropulos , Ahmad A Zainuddin , Seyed Rasoul Zakavi , Farhad Zamani , Sabina Zambon , Antonis Zampelas , Hana Zamrazilová , Maria Elisa Zapata , Abdul Hamid Zargar , Ko Ko Zaw , Tomasz Zdrojewski , Kristyna Zejglicova , Tajana Zeljkovic Vrkic , Yi Zeng , Luxia Zhang , Zhen-Yu Zhang , Dong Zhao , Ming-Hui Zhao , Wenhua Zhao , Shiqi Zhen , Wei Zheng , Yingfeng Zheng , Bekbolat Zholdin , Maigeng Zhou , Dan Zhu , Marie Zins , Emanuel Zitt , Yanina Zocalo , Julio Zuñiga Cisneros , Monika Zuziak , Majid Ezzati , Sarah Filippi, Epidemiology, Iurilli, Maria LC, Zhou, Bin, Bennett, James E, Carrillo-Larco, Rodrigo M, Sophiea, Marisa K, Rodriguez-Martinez, Andrea, Bixby, Honor, Solomon, Bethlehem D, Taddei, Cristina, Danaei, Goodarz, Di Cesare, Mariachiara, Stevens, Gretchen A, Riley, Leanne M, Savin, Stefan, Cowan, Melanie J, Bovet, Pascal, Damasceno, Albertino, Chirita-Emandi, Adela, Hayes, Alison J, Ikeda, Nayu, Jackson, Rod T, Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Miranda, J Jaime, Saidi, Olfa, Sebert, Sylvain, Sorić, Maroje, Starc, Gregor, Gregg, Edward W, Abarca-Gómez, Leandra, Abdeen, Ziad A, Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F Abdul, Abu-Rmeileh, Niveen M, Garba, Jamila Abubakar, Acosta-Cazares, 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Mohebbi, Iraj, Mohebi, Farnam, Moitry, Marie, Molbo, Drude, Møllehave, Line T, Møller, Niels C, Molnár, Déne, Momenan, Amirabba, Mondo, Charles K, Monroy-Valle, Michele, Monterrubio-Flores, Eric, Monyeki, Kotsedi Daniel K, Moon, Jin Soo, Moosazadeh, Mahmood, Moreira, Leila B, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Morin, Suzanne N, Mortensen, Erik Lykke, Moschonis, George, Mossakowska, Malgorzata, Mostafa, Aya, Mota-Pinto, Anabela, Mota, Jorge, Motlagh, Mohammad Esmaeel, Motta, Jorge, Moura-dos-Santos, Marcos André, Mridha, Malay K, Msyamboza, Kelias P, Mu, Thet Thet, Muc, Magdalena, Mugoša, Boban, Muiesan, Maria L, Mukhtorova, Parvina, Müller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Murtagh, Elaine M, Musa, Kamarul Imran, Milanovic, Sanja Music, Musil, Vera, Mustafa, Norlaila, Nabipour, Iraj, Naderimagham, Shohreh, Nagel, Gabriele, Naidu, Balkish M, Najafi, Farid, Nakamura, Harunobu, Námešná, Jana, Ei K Nang, Ei, Nangia, Vinay B, Nankap, Martin, Narake, Sameer, Nardone, Paola, Nauck, Matthia, Neal, William A, Nejatizadeh, Azim, Nekkantti, Chandini, Nelis, Keiu, Nelis, Lii, Nenko, Ilona, Neovius, Martin, Nervi, Flavio, Nguyen, Chung T, Nguyen, Nguyen D, Nguyen, Quang Ngoc, Nieto-Martínez, Ramfis E, Nikitin, Yury P, Ning, Guang, Ninomiya, Toshiharu, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A, Nogueira, Helena, Norat, Teresa, Nordendahl, Maria, Nordestgaard, Børge G, Noto, Davide, Nowak-Szczepanska, Natalia, Al Nsour, Mohannad, Nuhoglu, Irfan, Nurk, Eha, O'Neill, Terence W, O'Reilly, Dermot, Obreja, Galina, Ochimana, Caleb, Ochoa-Avilés, Angélica M, Oda, Eiji, Oh, Kyungwon, Ohara, Kumiko, Ohlsson, Clae, Ohtsuka, Ryutaro, Olafsson, Örn, Olinto, Maria Teresa A, Oliveira, Isabel O, Omar, Mohd Azahadi, Onat, Altan, Ong, Sok King, Ono, Lariane M, Ordunez, Pedro, Ornelas, Rui, Ortiz, Ana P, Ortiz, Pedro J, Osler, Merete, Osmond, Clive, Ostojic, Sergej M, Ostovar, Afshin, Otero, Johanna A, Overvad, Kim, Owusu-Dabo, Elli, Paccaud, Fred Michel, Padez, Cristina, Pagkalos, Ioanni, Pahomova, Elena, de Paiva, Karina Mary, Pajak, Andrzej, Palli, Domenico, Palloni, Alberto, Palmieri, Luigi, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Pandey, Arvind, Panza, Francesco, Papandreou, Dimitrio, Park, Soon-Woo, Park, Suyeon, Parnell, Winsome R, Parsaeian, Mahboubeh, Pascanu, Ionela M, Pasquet, Patrick, Patel, Nikhil D, Pecin, Ivan, Pednekar, Mangesh S, Peer, Nasheeta, Pei, Gao, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Peres, Marco A, Pérez-Farinós, Napoleón, Pérez, Cynthia M, Peterkova, Valentina, Peters, Annette, Petersmann, Astrid, Petkeviciene, Janina, Petrauskiene, Ausra, Pettenuzzo, Emanuela, Peykari, Niloofar, Pham, Son Thai, Pichardo, Rafael N, Pierannunzio, Daniela, Pigeot, Iri, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pistelli, Francesco, Pitakaka, Freda, Piwonska, Aleksandra, Pizarro, Andreia N, Plans-Rubió, Pedro, Poh, Bee Koon, Pohlabeln, Hermann, Pop, Raluca M, Popovic, Stevo R, Porta, Miquel, Posch, Georg, Poudyal, Anil, Poulimeneas, Dimitrio, Pouraram, Hamed, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J, Price, Jacqueline F, Providencia, Rui, Puder, Jardena J, Pudule, Iveta, Puhakka, Soile E, Puiu, Maria, Punab, Margu, Qasrawi, Radwan F, Qorbani, Mostafa, Bao, Tran Quoc, Radic, Ivana, Radisauskas, Ricarda, Rahimikazerooni, Salar, Rahman, Mahfuzar, Rahman, Mahmudur, Raitakari, Olli, Raj, Manu, Rakhimova, Ellina, Rakhmatulloev, Sherali, Rakovac, Ivo, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramke, Jacqueline, Ramos, Elisabete, Ramos, Rafel, Rampal, Lekhraj, Rampal, Sanjay, Rarra, Vayia, Rascon-Pacheco, Ramon A, Rasmussen, Mette, Rech, Cassiano Ricardo, Redon, Josep, Reganit, Paul Ferdinand M, Regecová, Valéria, Revilla, Lui, Rezaianzadeh, Abba, Ribas-Barba, Lourde, Ribeiro, Robespierre, Riboli, Elio, Richter, Adrian, Rigo, Fernando, Rinaldo, Natascia, de Wit, Tobias F Rinke, Rito, Ana, Ritti-Dias, Raphael M, Rivera, Juan A, Robitaille, Cynthia, Roccaldo, Romana, Rodrigues, Daniela, Rodríguez-Artalejo, Fernando, del Cristo Rodriguez-Perez, María, Rodríguez-Villamizar, Laura A, Roggenbuck, Ulla, Rojas-Martinez, Rosalba, Rojroongwasinkul, Nipa, Romaguera, Dora, Romeo, Elisabetta L, Rosario, Rafaela V, Rosengren, Annika, Rouse, Ian, Roy, Joel GR, Rubinstein, Adolfo, Rühli, Frank J, Ruidavets, Jean-Bernard, Ruiz-Betancourt, Blanca Sandra, Ruiz-Castell, Maria, Moreno, Emma Ruiz, Rusakova, Iuliia A, Jonsson, Kenisha Russell, Russo, Paola, Rust, Petra, Rutkowski, Marcin, Sabanayagam, Charumathi, Sacchini, Elena, Sachdev, Harshpal S, Sadjadi, Alireza, Safarpour, Ali Reza, Safiri, Saeid, Saki, Nader, Salanave, Benoit, Martinez, Eduardo Salazar, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Samoutian, Margarita, Sánchez-Abanto, Jose, Sandjaja, null, Sans, Susana, Marina, Loreto Santa, Santos, Diana A, Santos, Ina S, Santos, Lèlita C, Santos, Maria Paula, Santos, Osvaldo, Santos, Rute, Sanz, Sara Santo, Saramies, Jouko L, Sardinha, Luis B, Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savva, Savy, Mathilde, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Rosario, Angelika Schaffrath, Schargrodsky, Herman, Schienkiewitz, Anja, Schipf, Sabine, Schmidt, Carsten O, Schmidt, Ida Maria, Schnohr, Peter, Schöttker, Ben, Schramm, Sara, Schramm, Stine, Schröder, Helmut, Schultsz, Constance, Schutte, Aletta E, Sein, Aye Aye, Selamat, Rusidah, Sember, Vedrana, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sequera, Victor, Serra-Majem, Lui, Servais, Jennifer, Ševcíková, Ludmila, Shalnova, Svetlana A, Shamah-Levy, Teresa, Shamshirgaran, Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Shaw, Jonathan E, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shin, Dong Wook, Shirani, Majid, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Silva, Antonio M, Silva, Diego Augusto Santo, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöberg, Agneta, Sjöström, Michael, Skodje, Gry, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Söderberg, Stefan, Soekatri, Moesijanti YE, Soemantri, Agustinu, Sofat, Reecha, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild IA, Sørgjerd, Elin P, Jérome, Charles Sossa, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sovic, Slavica, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A, Stamm, Hanspeter, Stathopoulou, Maria G, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stevanovic, Ranko, Stieber, Jutta, Stöckl, Dori, Stocks, Tanja, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suárez-Medina, Ramón, Suka, Machi, Sun, Chien-An, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Swinburn, Boyd A, Sy, Rody G, Syddall, Holly E, Sylva, René Charle, Szklo, Moyse, Szponar, Lucjan, Tai, E Shyong, Tammesoo, Mari-Lii, Tamosiunas, Abdona, Tan, Eng Joo, Tang, Xun, Tanrygulyyeva, Maya, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Braunerová, Radka Taxová, Taylor, Anne, Taylor, Julie, Tchibindat, Félicité, Tebar, William R, Tell, Grethe S, Tello, Tania, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thijs, Lutgarde, Thomas, Nihal, Thuesen, Betina H, Tichá, Lubica, Timmermans, Erik J, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Topbas, Murat, Topór-Madry, Roman, Torheim, Liv Elin, Tormo, María José, Tornaritis, Michael J, Torrent, Matie, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Trichopoulos, Dimitrio, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsugane, Shoichiro, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L, Twig, Gilad, Tynelius, Per, Tzotzas, Themistokli, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Varona-Pérez, Patricia, Vasan, Senthil K, Vega, Toma, Veidebaum, Tooma, Velasquez-Melendez, Gustavo, Velika, Biruta, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Villalpando, Salvador, Vineis, Paolo, Vioque, Jesu, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Voutilainen, Ari, Voutilainen, Sari, Vrijheid, Martine, Vrijkotte, Tanja GM, Wade, Alisha N, Wagner, Aline, Waldhör, Thoma, Walton, Janette, Wambiya, Elvis OA, Bebakar, Wan Mohamad Wan, Mohamud, Wan Nazaimoon Wan, de Souza Wanderley Júnior, Rildo, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nichola, Weber, Adelheid, Wedderkopp, Niel, Weerasekera, Deepa, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Wiecek, Andrzej, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yaseri, Mehdi, Yasuharu, Tabara, Ye, Xingwang, Yiallouros, Panayiotis K, Yoosefi, Moein, Yoshihara, Akihiro, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Md Yusof, Safiah, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassili, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antoni, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Ko Zaw, Ko, Zdrojewski, Tomasz, Zejglicova, Kristyna, Vrkic, Tajana Zeljkovic, Zeng, Yi, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Cisneros, Julio Zuñiga, Zuziak, Monika, Ezzati, Majid, Filippi, Sarah, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université Paris Cité (UPCité), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
Subjects: Population -- Health aspects, Leanness, Baixo peso/Underweight, none, Double burden, alipainoisuus, tulotaso, global health, systematic analysis, Sedentary behaviors, RC1200, Prospective associations, 0302 clinical medicine, underweight, nälänhätä, Biology (General), skin and connective tissue diseases, Children, ComputingMilieux_MISCELLANEOUS, Body mass index, Human Nutrition & Health, education.field_of_study, Humane Voeding & Gezondheid, ylipaino, General Medicine, kansainvälinen vertailu, 3. Good health, World health, Medicine, A100 Pre-clinical Medicine, Population distribution, medicine.medical_specialty, QH301-705.5, Science, Socio-culturale, Nursing, Social sciences, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Thinness, SDG 3 - Good Health and Well-being, BMI, epidemiology, obesity, None, Humans, Obesidade/Obesity, SDG 2 - Zero Hunger, education, VLAG, US adults, Omvårdnad, body mass index, malnutrition, obesity, underweight, nutritional and metabolic diseases, medicine.disease, terveellisyys, Obesity, Faculdade de Ciências Sociais, Body Mass Index, Prevalence, Risk Factors, General Biochemistry, WIAS, lihavuus, RA, Demography, N.A, double burden, Settore MED/09 - Medicina Interna, alueelliset erot, Nutrition and Disease, Animal Nutrition, [SDV]Life Sciences [q-bio], Medizin, 030204 cardiovascular system & hematology, 0601 Biochemistry and Cell Biology, Change distribution of body mass index, RA0421, Voeding en Ziekte, Epidemiology, Medicine and Health Sciences, Global health, Índice de massa corporal/Body Mass Index, 030212 general & internal medicine, Underweight, painoindeksi, 2. Zero hunger, General Neuroscience, aliravitsemus, elintarvikkeet, health, Public Health, Global Health, Social Medicine and Epidemiology, Diervoeding, 3142 Public health care science, environmental and occupational health, purl.org/pe-repo/ocde/ford#3.01.03 [https], Chinese adults, pooled analysis, medicine.symptom, Diet quality, B120 Physiology, Research Article, trends, purl.org/pe-repo/ocde/ford#1.06.03 [https], prevalence, Population, Mothers, Genetics and Molecular Biology, 3121 Internal medicine, medicine, Life Science, ddc:610, 3125 Otorhinolaryngology, ophthalmology, kehonkoostumus, Nutrition, Australian adults, General Immunology and Microbiology, purl.org/pe-repo/ocde/ford#3.01.04 [https], Ciências sociais, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Malnutrition, Epidemiology and Global Health, sense organs, Estilos de Vida e Impacto na Saúde
Abstract: From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions., Wellcome Trust, Medical Research Council, peer-reviewed
Published: 2021
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14. High-Risk Histopathologic Features of Retinoblastoma Treated at a Tertiary Hospital in West Java, Indonesia

Author: Nur Melani Sari, Friska Mardianty, Regina Hadiputri, Hasrayati Agustina, and Maya Sari Kuntorini
Subjects: Pathology, medicine.medical_specialty, Tumor differentiation, Retinoblastoma, business.industry, Poorly differentiated, Medical record, West java, medicine.disease, Tertiary referral hospital, Eye health, medicine, Optic nerve, business, General Nursing, Research Article
Abstract: Purpose: To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation. Methods: This was a cross-sectional study of primary enucleated group D/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [Community Eye Health. 2018;31(101):17–3]. Results: This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25–36 months. High-risk features (HRFs) were found in 100/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age >2 years associated with tumor differentiation (p < 0.05). Conclusion: The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged >2 years old.
Published: 2021
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15. A Case Series of Malign Hyperechoic Breast Lesions

Author: Hafize Otcu Temur, Temel Fatih Yilmaz, Huseyin Toprak, Seyma Yildiz, Lutfullah Sari, and SARI, LÜTFULLAH
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Ductal carcinoma, Malignancy, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Toprak H., -A Case Series of Malign Hyperechoic Breast Lesions-, Current Medical Imaging Reviews, cilt.16, no.16, ss.766-773, 2020, 0302 clinical medicine, 030220 oncology & carcinogenesis, Invasive lobular carcinoma, Biopsy, medicine, Carcinoma, Radiology, Nuclear Medicine and imaging, Elastography, Radiology, Microcalcification, medicine.symptom, skin and connective tissue diseases, business, Breast ultrasound
Abstract: Background:: Hyperechoic breast lesions are a rare group of breast masses in routine practice. Most of these lesions are benign. However, they rarely may be malignant. Hyperechoic lesions can be evaluated using the same criteria for malignant lesions. Clinical history, mammographic appearance, and certain sonographic features (non-circumscribed margins, irregular shape, presence of hypoechoic areas, nonparallel orientation, and association with microcalcifications can be suggestive of malignancy). In this article, hyperechoic breast lesions with malignant pathology have been presented. Methods: : Seven cases during breast ultrasound examination were detected. Results:: Four patients had invasive ductal carcinoma, 1 patient had invasive lobular carcinoma, 1 patient had high-grade ductal carcinoma in situ (DCIS), and 1 patient had lymphoma. Ultrasonography of the breast showed a heterogeneous appearance in all the patients, microcalcification in two patients, and an ambiguous contour in one patient. Conclusion:: Hyperechoic breast lesions should be evaluated using specific sonographic criteria to prevent misdiagnosis and identify patients who require biopsy and further examination.
Published: 2020
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16. Efficacy of topical hydrogel Epigallocatechin-3-gallate against neutrophil cells in perforated dental pulp

Author: Paramita Tanjung Sari, Olivia Vivian Widjaja, Ari Subiyanto, Michelle Suhartono, Ria Puspita Sari, and Kun Ismiyatin
Subjects: Necrosis, business.industry, epigallocatechin-3-gallate (egcg), food and beverages, neutrophil, Inflammation, Pharmacology, medicine.disease, complex mixtures, Eugenol, lcsh:RK1-715, chemistry.chemical_compound, pulp perforation, chemistry, Polyphenol, inflammation, lcsh:Dentistry, Medicine, Pulp (tooth), Pulpitis, medicine.symptom, business, Cytotoxicity, General Dentistry, Pulp necrosis
Abstract: Background: One cause of pulpitis is mechanical trauma such as pulp perforation. The emergency treatment of pulpitis in a clinic uses eugenol. Eugenol in a high concentration causes cytotoxicity, which causes local necrosis and inhibits the recovery process, while in lower doses it can cause oral mucosal hypersensitivity. Due to these side effects, it is worth considering other biocompatible materials with minimal side effects, such as epigallocatechin-3-gallate (EGCG) which is found in green tea. As a polyphenol, EGCG has a radical scavenging ability, which has an effect on reducing the number of neutrophils. The application of EGCG is expected to reduce neutrophils on the second day after injury so the rehabilitation process is completed more quickly and ongoing inflammation and pulp necrosis is prevented. Purpose: To analyse the efficacy of topical hydrogel EGCG in reducing the number of neutrophils after 48 hours in the perforated dental pulp of Wistar rats. Method: 20 Wistar rats were divided equally into four groups, which were designated control (C) and treatment groups (T1, T2, T3). The upper first molar teeth of each rat were perforated and then T1, T2, and T3 were given 60 ppm, 90 ppm and 120 ppm hydrogel EGCG respectively. On the second day, the rats were sacrificed. HPA preparations were made to calculate the number of neutrophils in each group. Data was analysed using Kolmogorov–Smirnov, Levene’s, one-way ANOVA and Tukey HSD test (p0.05). Conclusion: 90 ppm hydrogel EGCG is effective in reducing the number of neutrophils in the perforated dental pulp of Wistar rats.
Published: 2020

17. FACTORS INFLUENCING HIV KNOWLEDGE AMONG WOMEN OF CHILDBEARING AGE IN SOUTH SUMATRA, INDONESIA

Author: Sharyn Graham Davies, Najmah, Tri Novia Kumalasari, Sari Andajani, and Indah Purnama Sari
Subjects: Transmission (medicine), business.industry, Public Health, Environmental and Occupational Health, medicine.disease, Stratified sampling, Acquired immunodeficiency syndrome (AIDS), medicine, Marital status, Residence, Social determinants of health, Rural area, business, Socioeconomic status, Demography
Abstract: This study aims to provide detailed information on the role of the following social determinants (i.e. education, occupation, place of residence, marital and economic status) in the acquisition of HIV knowledge among women of childbearing age (15-49 years old). The study uses secondary data from the 2012 Indonesian Demographic and Health Survey (IDHS). The IDHS used a quantitative analytical approach with a cross-sectional study design and multi-stage stratified sampling. The sample included 1,335 women aged 15 to 49 years old living in South Sumatra Province, Indonesia. Descriptive analysis, ANOVA, and t-test and multiple logistic regressions were performed in this study. The results show one out of two women have little HIV knowledge. The more highly educated women were positively associated with a greater degree of knowledge related to comprehensive knowledge related to HIV (AOR: 3.7, 2.2-6.2, p.
Published: 2020
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18. Vitamin D Deficiency and Hematological Parameters in People Living with HIV/AIDS

Author: Juli Yosa Mega, Elrica, Dina Keumala Sari, and Dewi Indah Sari Siregar
Subjects: Nutrition and Dietetics, Acquired immunodeficiency syndrome (AIDS), business.industry, Immunology, Public Health, Environmental and Occupational Health, Medicine, business, medicine.disease, vitamin D deficiency, Food Science
Published: 2020
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19. Empowering the Role of the Integrated Foster Post Cadres in Improving the Quality of Life of Diabetes Mellitus Patients

Author: Desy Siswi Anjar Sari, Fitri Firranda Nurmalisyah, and Alik Septian Mubarok
Subjects: Gerontology, business.industry, Diabetes mellitus, Medicine, business, medicine.disease
Abstract: Introduction: Nurses as one of the health workers have a role in managing Diabetes Mellitus patients, the quality life of Diabetes Mellitus patients affects physical health, psychological conditions, level of dependence, social relations and the patient's relationship with the surrounding environment. Actions and interventions in controlling Diabetes Mellitus disease require appropriate therapeutic regimens, as well as involving families. By empowering the health cadres, it can improve the quality life of people with Diabetes Mellitus who are in the working area of the Kesamben Health Center, Jombang Regency. Methods: This research is a quasi-experimental study with a non-randomized control group pre-test post- test design. In this study, the treatment group was given a treatment in the form of training for Integrated Foster Post Cadres to improve for Diabetes Mellitus, while the control group was not given any treatment. Results: The results showed that there was a significant difference in the quality of life between the treatment group and the control group due to skills improvement training for Integrated Foster Post Cadres Diabetes Mellitus with the results of the independent t test on self-efficacy obtained t value of 25.055 (p = 0.000), while the value t of quality life is 25,790 (p = 0,000). Conclusion: Nurses can empower Integrated Foster Post Cadres in the community by improving the quality of life for people with Diabetes Mellitus. Integrated Foster Post Cadres play an active role in the community in the scope of knowledge, signs and symptoms, complications of Diabetes Mellitus which can encourage DM sufferers to be motivated to improve the quality of life.
Published: 2021
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20. A prospective longitudinal study of chronic pulmonary aspergillosis in pulmonary tuberculosis in Indonesia (APICAL)

Author: Robiatul Adawiyah, Johannes Ramnath, Cut Yulia I. Sari, Retno Wahyuningsih, Anna Rozaliyani, Riina Rautemaa-Richardson, Ridhawati Syam, Arief Riadi Arifin, Erlina Burhan, Martin Rumende, Mulyati Tugiran, Diah Handayani, David W. Denning, Findra Setianingrum, and Finny Nandipinto
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, Serology, Internal medicine, Diabetes mellitus, medicine, Humans, Longitudinal Studies, Prospective Studies, Tuberculosis, Pulmonary, Antibodies, Fungal, business.industry, Incidence (epidemiology), Chronic pulmonary aspergillosis, medicine.disease, Indonesia, Immunoglobulin G, Chronic Disease, Sputum, Persistent Infection, Pulmonary Aspergillosis, Differential diagnosis, medicine.symptom, business, Aspergilloma
Abstract: ObjectivesChronic pulmonary aspergillosis (CPA) can complicate recovery from pulmonary TB. CPA may also be misdiagnosed as bacteriologically negative TB. This study aimed to determine the incidence of CPA in patients treated for TB in Indonesia, a country with a high incidence of TB.MethodsIn this prospective, longitudinal cohort study in patients treated for pulmonary TB, clinical, radiological and laboratory findings were analysed. Sputum was collected for fungal culture and TB PCR. Patients were assessed at baseline (0–8 weeks) and at the end (5–6 months) of TB therapy. CPA diagnosis was based on symptoms (≥3 months), characteristic radiological features and positive Aspergillus serology, and categorised as proven, probable and possible.ResultsOf the 216 patients recruited, 128 (59%) were followed up until end of TB therapy. At baseline, 91 (42%) had microbiological evidence for TB. Aspergillus-specific IgG was positive in 64 (30%) patients and went from negative to positive in 16 (13%) patients during TB therapy. The incidence rates of proven and probable CPA at baseline were 6% (n=12) and 2% (n=5) and end of TB therapy 8% (n=10) and 5% (n=7), respectively. Six patients (two with confirmed TB) developed an aspergilloma. Diabetes mellitus was a significant risk factor for CPA (p=0.040). Persistent cough (n=5, 50%; p=0.005) and fatigue (n=6, 60%; p=0.001) were the most common symptoms in CPA.ConclusionCPA should be considered a relatively frequent differential diagnosis in patients with possible or proven TB in Indonesia. Lack of awareness and limited access to Aspergillus-specific IgG tests and CT imaging are obstacles in establishing a CPA diagnosis.
Published: 2021
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21. The Effectiveness of Herbal Antibacterial Formulations Against Mastitis-Causing Bacteria in Dairy Cattle

Author: Sari Suryanah and Syifa Nurjannah
Subjects: biology, Traditional medicine, Chloramphenicol, food and beverages, General Medicine, medicine.disease_cause, biology.organism_classification, Betel, medicine.disease, Mastitis, Streptococcus agalactiae, Staphylococcus aureus, medicine, Escherichia coli, Bacteria, Dairy cattle, medicine.drug
Abstract: This study aimed to determine the effectiveness of antibacterial formulations derived from herbal plants against mastitis-causing bacteria in dairy cattle. Herbal extracts composed of betel leaves extract, kecombrang flower extract, and turmeric extract were tested against Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli. The research was carried out in a Completely Randomized Design (CRD) using ten treatments and four replications at the Laboratory of Research and Testing, Faculty of Animal Husbandry, Padjadjaran University. The results showed that herbal antibacterial formulations could inhibit the growth of Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli bacteria. The most inhibitory power was obtained from P8 treatment (50% betel leaves + 50% kecombrang flower + 50% turmeric) categorized in "strong inhibition." The percentage of antibacterial inhibition of P8 formulation compared to chloramphenicol was 32% against Staphylococcus aureus, 33% against Streptococcus agalactiae, and 31% against Escherichia coli. Conclusively, the best herbal antibacterial formulation was a combination of 50% betel leaves extract, 50% kecombrang flower extract, and 50% turmeric extract.
Published: 2021
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22. Vertaistoiminnan muodot ja merkitys päihde- ja mielenterveysjärjestöissä

Author: Sari Jurvansuu and Päivi Rissanen
Subjects: vertaistuki, Supplementary data, Substance abuse, Tieteelliset artikkelit, medicine, vertaistoiminta, päihdejärjestöt, mielenterveysjärjestöt, Peer support, medicine.disease, Psychology, Mental health, Social psychology
Abstract: Artikkelissa tarkastellaan vertaistoimintaa päihde- ja mielenterveysjärjestöissä. Tutkimusaineisto koostuu kahdesta kyselystä. Ensimmäisessä kartoitettiin paikallisten päihde- ja mielenterveysyhdistysten (n=187) ja valtakunnallisten järjestöjen (n=28) johtajien käsityksiä vertaisuuden merkityksestä niiden toiminnassa sekä niissä tuotettavia vertaistoiminnan muotoja. Täydentävää aineistoa kerättiin järjestöjen työntekijöille (n=61) ja vertaisille (n=75) kohdistetulla kyselyllä, jossa tarkasteltiin vertaistoiminnan merkitystä, siihen liittyviä tehtäviä, vertaisten roolia ja asemaa sekä heihin kohdistuvia tukitoimenpiteitä ja tuen tarvetta.Vertaistoiminnalla oli keskeinen merkitys päihde- ja mielenterveysjärjestökentällä. Sen painoarvo kuitenkin vaihteli. Vertaistoiminnan merkitys oli suurempi ja siihen liittyviä toimintamuotoja oli enemmän suurilla toiminta-alueilla toimivissa yhdistyksissä. Sen painoarvo korostui etenkin ennen vuotta 1986 perustetuissa yhdistyksissä.Vertaisten rooli ja tehtävät hahmottuivat hieman eri tavoin työntekijöiden ja vertaisten itsensä näkökulmasta.Työntekijät korostivat vertaisten roolia järjestöjen asiakastyössä ja konkreettisessa auttamis- ja tukitoiminnassa, kun taas vertaiset itse näkivät roolinsa laajemmin myös järjestön ulkosuhteissa ja yhteiskunnallisina vaikuttajina. Aineiston vertaisista kolmannes oli kokenut uupumusta tai väsymystä toimiessaan vertaisena. Järjestöissä on tärkeää taata sekä vertaisten oman orientaation huomioiminen toiminnan suunnittelussa ja kehittämisessä että tarvittavat resurssit vertaisten tukemiseen. AbstractThe forms and importance of peer support in substance abuse and mental health organizations The study examines peer support in substance abuse and mental health organizations. The study is based on two sets of data. Information on the importance and forms of peer support provided was collected by a questionnaire sent to local (n=187) and national (n=28) non-governmental organizations in the fields of substance abuse and mental health, addressed to the CEO or chairman of the board. Supplementary data on the roles and tasks of peers as well as their need for support in their own work was collected by a questionnaire sent to the personnel (n=61) and peers (n=75) in these organizations. Peer support had a central role in both substance abuse and mental health organizations but it differed in different kinds of organizations. Peer support had a stronger emphasis and was more common in organizations operating in larger cities. Also, organizations founded especially before year 1986 had a stronger element of peer support in them compared to younger organizations. The peers’ roles and tasks were perceived somewhat differently by the personnel and the peers themselves. The personnel emphasized the peers’ role in the organization’s customer work and practical help and support related tasks, whereas the peers themselves perceived their role more broadly, including in the organizations’ external relations and in advocacy work. Every third of the peers who answered the questionnaire had experienced fatigue or exhaustion in their work as a peer. The results highlight the need to consider the peer workers’ own orientation and expectations in planning peer support in substance and mental health organizations, as well as the need to provide sufficient resources for supporting the peers’ well-being and coping skills in their work. Keywords: peer, peer support, NGO, substance abuse organizations, mental health organizations
Published: 2021
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23. Clinically Administered Doses of Pitavastatin and Rosuvastatin

Author: Masafumi Funamoto, Yoichi Sunagawa, Sae Hirano, Yusuke Miyazaki, Koji Hasegawa, Hikaru Sato, Satoshi Shimizu, Nurmila Sari, Tatsuya Morimoto, Yasufumi Katanasaka, and Kana Shimizu
Subjects: Statin, Cardiac fibrosis, business.industry, medicine.drug_class, General Medicine, Pharmacology, urologic and male genital diseases, medicine.disease, Muscle hypertrophy, Pharmacokinetics, Heart failure, medicine, Rosuvastatin, Cardiology and Cardiovascular Medicine, business, Pitavastatin, neoplasms, therapeutics, Phenylephrine, medicine.drug
Abstract: Clinical studies have indicated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, also known as statins, can potentially inhibit chronic heart failure. In the Stat-LVDF study, a difference was noted in terms of the effect of lipophilic pitavastatin (PTV) and hydrophilic rosuvastatin (RSV) on plasma BNP, suggesting that statin lipophilicity and pharmacokinetics change the pleiotropic effect on heart failure in humans. Therefore, we assessed the beneficial effects of PTV on hypertrophy in cardiac myocytes compared with RSV at clinically used doses. Cultured cardiomyocytes were stimulated with 30 μM phenylephrine (PE) in the presence of PTV (250 nM) or RSV (50 nM). These doses were calculated based on the maximum blood concentration of statins used in clinical situations in Japan. The results showed that PTV, but not RSV, significantly inhibits the PE-induced increase in cell size and leucine incorporation without causing cell toxicity. In addition, PTV significantly suppressed PE-induced mRNA expression of hypertrophic response genes. PE-induced ERK phosphorylation was inhibited by PTV, but not by RSV. Furthermore, PTV significantly suppressed the angiotensin-II-induced proline incorporation in primary cultured cardiac fibroblasts. In conclusion, a clinical dose of PTV was noted to directly inhibit cardiomyocyte hypertrophy and cardiac fibrosis, suggesting that lipophilic PTV can be a potential drug candidate against chronic heart failure.
Published: 2021
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24. Gender Disparities in Their Effects on Characteristics and Prognostics of Lung Cancer Patients in Pulmonary Ward of Dr. M Djamil Hospital, Padang

Author: Sabrina Ermayanti, Sari Nikmawati, Afriani Afriani, Irvan Medison, Suyastri Suyastri, and Russilawati Russilawati
Subjects: medicine.medical_specialty, business.industry, Incidence (epidemiology), Advanced stage, Cancer, medicine.disease, Former Smoker, Psychiatry and Mental health, Internal medicine, Epidemiology, medicine, Carcinoma, Life expectancy, Lung cancer, business
Abstract: Background: Lung cancer incidence in female tends to increase in many countries. Various studies have reported the characteristics of lung cancer in female are different from male. The purpose of this study was to determine the effect of gender on characteristics of lung cancer at Dr. M Djamil Hospital, Padang.Methods: A retrospective analytic study of lung cancer patients treated in the Pulmonary Ward of Dr. M. Djamil Hospital Padang from January 1, 2004 to December 31, 2017, with recognized cancer cell types. Data were grouped according to gender.Results: This study found that 451 lung cancer patients, male-dominant 77.8%. Female were younger than male (52.97 ± 12.79 years vs. 57.81 ± 11.23 years; p = 0.00). Most of male (94.5%) were smokers and former smokers, while 93.9% of female were non-smokers (p = 0.00). Most female were having prior history of tuberculosis (TB) (21.2% vs 11.0%; p = 0.008) and also prior history of other organs cancer (10.1% vs 3.4%; p = 0.007) than in male. Squamous cells were highest in males (41.1%), while females had adenocarcinoma (55.0%); with p = 0.008. Advanced stage in female more than male (91.8% vs 82.7%; p = 0.027). The mean life expectancy of female was longer than male, respectively 8.74 ± 1.56 and 7.29 ± 0.64 months; (p = 0.95). Conclusion: There are differences in the epidemiology of lung cancer between male and female in Dr. M. Djamil Hospital Padang in the form of age, cell type and staging. Non-smokers, a previous history of TB and a history of cancer in other organs were more dominant in female.
Published: 2021
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25. von Willebrand Factor Gene Polymorphism in Preeclampsia Pregnant at Medan, Indonesia

Author: Syah Mirsya Warli, Dewi Indah Sari Siregar, Gontar Alamsyah Siregar, and Muhammad Fidel Ganis Siregar
Subjects: Von Willebrand Factor Gene, Polymorphism (computer science), business.industry, hemic and lymphatic diseases, Immunology, medicine, General Medicine, medicine.disease, business, circulatory and respiratory physiology, Preeclampsia
Abstract: BACKGROUND: von Willebrand Factor (vWF) is a large glycoprotein mediating hemostasis and thrombosis. The roles of vWF are platelets adhesion to sites of vascular damage and stabilization of coagulation factor VIII. AIM: This study aimed to analyze the polymorphism of the vWF gene on preeclampsia (PE) in pregnancy in Medan, Indonesia. MATERIALS AND METHODS: DNA was amplified using the polymerase chain reaction and was electrophoresed in agarose 2%. Electrophoresis results were detected using Gel Doc 1000 (Biorad, USA). The sequencing method was used to identify polymorphism from vWF gene. RESULTS: From 50 samples of PE patients, the g.93308C>T vWF gene polymorphism was found with the percentage of TT, CT, and CC genotypes as 50%, 42%, and 8%, respectively. CONCLUSION: The c.93308C>T vWF gene polymorphism was found in the genotype percentage of homozygous TT, and heterozygote CT was greater than wild-type CC.
Published: 2021
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26. Nivolumab Versus Gemcitabine or Pegylated Liposomal Doxorubicin for Patients With Platinum-Resistant Ovarian Cancer: Open-Label, Randomized Trial in Japan (NINJA)

Author: Hisamori Kato, Nobuhiro Takeshima, Noriyuki Katsumata, Takayuki Enomoto, Hidemichi Watari, Yusuke Takahashi, Junzo Hamanishi, Takashi Matsumoto, Koji Matsumoto, Kimio Ushijima, Kazuhiro Takehara, Hidekatsu Nakai, Ikuo Konishi, Takashi Sawasaki, Toru Sugiyama, Masaki Mandai, Satoshi Takeuchi, Akira Takazawa, Kimihiko Ito, Eiji Kondo, Yoichi Aoki, Noriaki Sakuragi, Satomi Aihara, Hiroshi Kobayashi, Toshiaki Saito, Aikou Okamoto, Daisuke Aoki, Nobutaka Takahashi, Kosei Hasegawa, Satoru Nagase, Yoshinobu Namba, Tadashi Kimura, Mika Mizuno, Kan Yonemori, Yoshito Terai, Keiichi Fujiwara, Hitoshi Niikura, Kenzo Sonoda, Nao Suzuki, Hirokuni Takano, Sari Nakao, and Hidenori Kato
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, medicine.disease, Gemcitabine, law.invention, Pegylated Liposomal Doxorubicin, Randomized controlled trial, law, Internal medicine, medicine, Open label, Nivolumab, Ovarian cancer, business, medicine.drug, Platinum resistant
Abstract: PURPOSE This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer. MATERIALS AND METHODS Eligible patients had platinum-resistant epithelial ovarian cancer, received ≤ 1 regimen after diagnosis of resistance, and had an Eastern Cooperative Oncology Group performance score of ≤ 1. Patients were randomly assigned 1:1 to nivolumab (240 mg once every 2 weeks [as one cycle]) or chemotherapy (GEM 1000 mg/m2 for 30 minutes [once on days 1, 8, and 15] followed by a week's rest [as one cycle], or PLD 50 mg/m2 once every 4 weeks [as one cycle]). The primary outcome was overall survival (OS). Secondary outcomes included progression-free survival (PFS), overall response rate, duration of response, and safety. RESULTS Patients (n = 316) were randomly assigned to nivolumab (n = 157) or GEM or PLD (n = 159) between October 2015 and December 2017. Median OS was 10.1 (95% CI, 8.3 to 14.1) and 12.1 (95% CI, 9.3 to 15.3) months with nivolumab and GEM or PLD, respectively (hazard ratio, 1.0; 95% CI, 0.8 to 1.3; P = .808). Median PFS was 2.0 (95% CI, 1.9 to 2.2) and 3.8 (95% CI, 3.6 to 4.2) months with nivolumab and GEM or PLD, respectively (hazard ratio, 1.5; 95% CI, 1.2 to 1.9; P = .002). There was no statistical difference in overall response rate between groups (7.6% v 13.2%; odds ratio, 0.6; 95% CI, 0.2 to 1.3; P = .191). Median duration of response was numerically longer with nivolumab than GEM or PLD (18.7 v 7.4 months). Fewer treatment-related adverse events were observed with nivolumab versus GEM or PLD (61.5% v 98.1%), with no additional or new safety risks. CONCLUSION Although well-tolerated, nivolumab did not improve OS and showed worse PFS compared with GEM or PLD in patients with platinum-resistant ovarian cancer.
Published: 2021

27. EVALUASI WAKTU TUNGGU PELAYANAN RESEP PASIEN RAWAT JALAN DI RUMAH SAKIT ANWAR MEDIKA

Author: Erviani Dinda Mahmudah Sari, Puspita Raras Anindita, and Khurin In Wahyuni
Subjects: Waiting time, business.industry, Direct observation, Medicine, Christian ministry, Medical emergency, Medical prescription, business, medicine.disease, Concoction
Abstract: The waiting time for finished drug service is the grace period from the time the patient submits the prescription until receiving the finished drug with a minimum standard set by the Ministry of Health is ≤ 30 minutes, while the waiting time for concoction drug service is the grace period from the time the patient submits the prescription until receiving the concoction drug that is ≤ 60 minutes. This study aims to determine the average waiting time for outpatient prescription services at Anwar Medika Hospital. This research was conducted with a cross sectional descriptive method. Primary data was collected through direct observation and recording of prescription service waiting times in the waiting time recording form on February 10, 2020 to February 11, 2020. Data taken were 384 outpatient prescriptions consisting of 346 non-concoctions and 38 prescription concoctions. In this study, 384 recipes were used as the research sample consisting of 346 for non-concoction recipes and 38 for recipe concoctions. The average time needed to complete a non-concoction recipe is 18.7 minutes and the time required to complete a recipe concoction is 30.9 minutes. Based on the results of research that has been done, it is found that the average waiting time for prescription services at Anwar Medika Hospital has fulfilled the requirements according to the minimum service standards at the hospital.
Published: 2021
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28. Extended family thalassemia screening as a feasible alternative method to be implemented in identifying carriers in West Java, Indonesia

Author: Delita Prihatni, Puspasari Sinaga, Jessica Oktavianus Trisaputra, Lulu Eva Rakhmilla, Susi Susanah, Nur Melani Sari, and Yunia Sribudiani
Subjects: Alternative methods, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Thalassemia, Public Health, Environmental and Occupational Health, Case-control study, Feasible, Extended family, West java, medicine.disease, Thalassemia screening, hemic and lymphatic diseases, Thalassemia carrier, Screening, Medicine, Original Article, General hospital, business, Index case, Genetics (clinical)
Abstract: The thalassemia screening program in Indonesia mostly conducted sporadically. Ideal prospective screening is still limited. This study aimed to compare thalassemia screening methods using the extended family approach with and without a history of severe thalassemia and the feasibility of implementing extended family screening method. A case control study was conducted in Dr. Hasan Sadikin General Hospital Bandung with 3 generations of extended families. Data were collected from 150 subjects of 8 extended families with severe thalassemia as an index case entry and 151 subjects of 12 families with no history of thalassemia. All subjects were examined for Hb, MCV, MCH, and peripheral blood smear (PBS) as initial laboratory examinations. Subjects with MCV p p = 0.244). The mean age was 31.9 ± 21.2 vs. 31.1 ± 20.8 years (p = 0.782). The median family size was 28.5 vs. 20 subjects per family (p = 0.245). The types of identified thalassemia carrier in both groups consisted of β-thalassemia, β-thalassemia/HbE, suspected α-thalassemia, and β-thalassemia Hb variant. All carriers continued the counseling process. The extended family method seems feasible to be implemented for thalassemia screening in West Java, Indonesia.
Published: 2021
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29. Orta-Ağır Bronkopulmoner Displazide Tek Merkez Deneyimi: Antenatal ve Postnatal Risk Faktörleri

Author: Fatma Nur Sari, Mehmet Büyüktiryaki, Suna Oguz, Buse Ozer Bekmez, Cüneyt Tayman, and Evrim Alyamac Dizdar
Subjects: General and Internal Medicine, medicine.medical_specialty, Parenteral nutrition, Bronchopulmonary dysplasia, business.industry, Obstetrics, Medicine, Bronchopulmonary dysplasia,Enteral nutrition,Prematurity, business, medicine.disease, Genel ve Dahili Tıp, bronkopulmoner displazi,prematürite,enteral beslenme
Abstract: Amaç: Bronkopulmoner displazi (BPD), çok düşük doğum ağırlıklı her üç bebekten birini etkileyen uzun dönem ciddi olumsuz sonuçları olan bir prematüre morbiditesidir. Bu çalışmada orta-ağır BPD için antenatal ve postnatal risk faktörlerini araştırmayı amaçladık. Gereç ve Yöntemler: Tek merkezli retrospektif kohort çalışmada Ocak 2014-Aralık 2018 tarihleri arasında doğan, Objective: Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects a substantial proportion of extremely preterm infants. We aimed to find out the antenatal and postnatal risk factors for BPD in a large-scale cohort of preterm infants. Material and Methods: Records of preterm infants born
Published: 2021
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30. Mitral Valve Translocation: Optimization of Patch Geometry in an Ex Vivo Model of Secondary Mitral Regurgitation

Author: Chetan Pasrija, Rachael W. Quinn, James S. Gammie, Daniel A. Bernstein, and Sari D. Holmes
Subjects: Mitral regurgitation, Mitral valve repair, business.industry, medicine.medical_treatment, Pharmaceutical Science, Chromosomal translocation, Geometry, medicine.disease, medicine.anatomical_structure, Heart failure, Mitral valve, Genetics, medicine, Molecular Medicine, Cardiology and Cardiovascular Medicine, business, Papillary muscle, Functional mitral regurgitation, Genetics (clinical), Ex vivo
Abstract: Optimal translocation patch width for functional mitral regurgitation (FMR) treatment was evaluated in an air-filled ex vivo system. FMR was created in 19 isolated swine hearts by annular dilation and papillary muscle displacement. Frustum-shaped pericardial patches of varying widths (Group 1 = 0.5 cm; Group 2 = 1.0 cm; Group 3 = 1.5 cm) were implanted and imaged via a 3D-structured light scanner. Median leaflet coaptation decreased (P
Published: 2021
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31. The Burden of Penile Cancer in Bali Compared to Other Provinces in Indonesia

Author: I Nyoman Putu Riasa, Rika Mubarika Haryana, Kartika Sari, Ni Wayan Armerinayanti, Desak Putu Oki Lestari, Putu Kania Iswari Niramayah, Putu Nita Cahyawati, and Irianiwati Widodo
Subjects: education.field_of_study, business.industry, Incidence (epidemiology), Population, Cancer, General Medicine, medicine.disease, language.human_language, Indonesian, language, medicine, Penile cancer, education, business, Demography
Abstract: Objective: In Indonesia, 45% of the total penile cancer cases are concentrated in Bali province, where penile cancer is ranked as the most common cancer during 2013. However, the incidences of penile cancer in Bali and other provinces in Indonesia are still unknown. The purpose of this study is to determine the age-standardized incidence rate (ASR), age-specific incidence rate (AR), and crude rate incidence (CRI) of penile cancer in Bali and other provinces in Indonesia. Methods: The data were obtained from 11 provinces in Indonesia over a period of 10 years (2004-2013). The samples were 1032 new cases of penile cancer collected manually from the registry. ASR, AR, and CRI were calculated based on the number of new penile cancer cases per 100,000 men in a given province. Indonesian population standard was used to calculate the age-standardized incidence rate. Result: There were variations on ASR, AR, and CRI for penile cancer in Indonesia. We found that the average CRI in Indonesia is 0.1 per 100,000 men. The incidence is found to be higher in Bali compared to other provinces. The average ASR in Bali is 2.1 per 100,000 men, CRI is 2.5 per 100,000 men, and the peak of AR being 12.9 per 100,000 men in the age group of 55-64 years old. The incidence of penile cancer is found to increase with age. In Bali, the peak incidence is in the 6th and 7th decades of life. The ASR and CRI of penile cancer in other provinces were less than 1 per 100,000 males. Conclusion: The highest incidence of penile cancer is found in the Bali province compared to other provinces in Indonesia. This problem requires more serious attention and further research to identify the risk factors.
Published: 2021
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32. Maternal energy-adjusted fatty acid intake during pregnancy and the development of cows’ milk allergy in the offspring

Author: H. Tapanainen, Riitta Veijola, Jorma Toppari, Hanna-Mari Takkinen, Jorma Ilonen, Anni Lamminsalo, Johanna Metsälä, Sari Niinistö, Minna Kaila, Mikael Knip, Mari Åkerlund, and Suvi M. Virtanen
Subjects: Offspring, Linoleic acid, Population, Medicine (miscellaneous), Physiology, Milk allergy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, 030212 general & internal medicine, education, 2. Zero hunger, chemistry.chemical_classification, education.field_of_study, Pregnancy, Nutrition and Dietetics, business.industry, Fatty acid, medicine.disease, 3. Good health, 030228 respiratory system, chemistry, Infant animal, business, Polyunsaturated fatty acid
Abstract: Cows’ milk allergy (CMA) is one of the earliest manifestations of allergic diseases. Early dietary factors, like maternal diet during pregnancy, may play a role in the development of allergic diseases in the offspring. We aimed to investigate the association between maternal intake of fatty acids during pregnancy and the risk of CMA in the offspring. Our study was conducted in a population-based cohort, the Finnish Type 1 Diabetes Prediction and Prevention study. We collected the maternal dietary data by a validated FFQ. We obtained the information on CMA in the study participants (n 448) from registers and from the parents. Dietary data and information on CMA were available for 4921 children. We used logistic regression in the analyses, and fatty acid intakes were energy adjusted. The maternal intake of SFA, MUFA, PUFA, n-3 PUFA, n-6 PUFA, trans fatty acids, ratio of n-3 PUFA to n-6 PUFA or ratio of linoleic acid to α-linolenic acid was not associated with the risk of CMA in the offspring when adjusted for perinatal factors, background factors, parental history of asthma or allergic rhinitis and infant animal contacts. The intake of α-linolenic acid was associated with a decreased risk (OR 0·72; 95 % CI 0·56, 0·93) of CMA in the offspring of mothers without a history of allergic rhinitis or asthma. In conclusion, the maternal intake of fatty acids during pregnancy is not associated with the risk of CMA in the offspring.
Published: 2021
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33. Spiritual Emotional Freedom Technique against Anxiety and Psychological Well-being of Type 2 DM Patients during the COVID-19 Pandemic

Author: Umdatus Soleha, Imamatul Faizah, Raden Khairiyatul Afiyah, Ratna Yunita Sari, Abdul Muhith, Riska Rohmawati, and Firman Suryadi Rahman
Subjects: Research design, business.industry, Type 2 Diabetes Mellitus, General Medicine, Type 2 diabetes, medicine.disease, Rating scale, Psychological well-being, Intervention (counseling), Inclusion and exclusion criteria, medicine, Anxiety, medicine.symptom, business, Clinical psychology
Abstract: BACKGROUND: The COVID-19 pandemic makes patients with type 2 diabetes mellitus experience an increase in anxiety, considering that diabetes mellitus is one of the dangerous comorbidities for people infected with the COVID-19 virus so that it affects their psychological well-being. Low psychological well-being will have an impact on decreasing self-care, thereby increasing the occurrence of complications. AIM: The purpose of this study was to analyze the effect of the spiritual emotional freedom technique (SEFT) on anxiety and the psychological well-being of patients with type 2 DM during the COVID-19 pandemic. METHODS: The research design employed is a quasi-experimental research with the untreated control group design with dependent pre-test and post-test samples. The sampling technique used is probability sampling which is a random sampling to meet the inclusion and exclusion criteria with a total sample of 110 respondents with the distribution of the intervention group consisting of 55 respondents and the control group consisting of 55 respondents. The instrument used to measure the level of anxiety is the Hamilton Rating Scale for Anxiety and psychological well-being of Ryff’s psychological well-being. The statistical tests used are Paired Sample t-Test and Independent t-test with significant p < 0.05. RESULTS: The results showed that the mean level of anxiety in the intervention group before the implementation of the intervention was 21.89 (moderate), while after the intervention was 10.98 (mild) and the psychological well-being before the intervention was 147.49 (low), while after the intervention was 170.91 (moderate). Furthermore, in the case of the control group, the mean level of anxiety before the intervention was 19.16 and after the intervention was 19.11 and psychological well-being before the intervention was 146.67 while after the intervention was 146.45. Furthermore, the data analysis obtained that the SEFT affected the level of anxiety and psychological well-being of patients with type 2 diabetes during the COVID-19 pandemic with p = 0.00. CONCLUSION: The SEFT that is routinely implemented can reduce the level of anxiety so that it can improve the psychological well-being of patients with type 2 DM during the COVID-19 pandemic.
Published: 2021
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34. Pretreatment clinical and hematologic prognostic factors of metastatic urothelial carcinoma treated with pembrolizumab: a systematic review and meta-analysis

Author: Takahiro Kimura, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Abdulmajeed Aydh, Jun Miki, Frederik König, Pawel Rajwa, Satoshi Katayama, Keiichiro Mori, Shin Egawa, Benjamin Pradere, Nico C. Grossmann, Ekaterina Laukhtina, Takafumi Yanagisawa, and Shahrokh F. Shariat
Subjects: Oncology, medicine.medical_specialty, Metastatic Urothelial Carcinoma, Review Article, Pembrolizumab, Antibodies, Monoclonal, Humanized, Metastasis, Surgical oncology, Internal medicine, Humans, Medicine, Retrospective Studies, Carcinoma, Transitional Cell, Prognostic factor, Visceral metastasis, business.industry, Hazard ratio, Hematology, General Medicine, Prognosis, Metastatic urothelial carcinoma, medicine.disease, Confidence interval, Urinary Bladder Neoplasms, Meta-analysis, Surgery, business
Abstract: Pembrolizumab is the standard for the first and second lines in treating metastatic urothelial carcinoma (UC). This systematic review and meta-analysis aimed to assess the value of pretreatment clinical characteristics and hematologic biomarkers for prognosticating response to pembrolizumab in patients with metastatic UC. PUBMED®, Web of Science™, and Scopus® databases were searched for articles published before May 2021 according to the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) statement. Studies were deemed eligible if they evaluated overall survival (OS) in patients with metastatic urothelial carcinoma treated with pembrolizumab and pretreatment clinical characteristics or laboratory examination. Overall, 13 studies comprising 1311 patients were eligible for the meta-analysis. Several pretreatment patients’ demographics and hematologic biomarkers were significantly associated with worse OS as follows: Eastern Cooperative Oncology Group Performance Status (ECOG-PS) ≥ 2 (Pooled hazard ratio [HR]: 3.24, 95% confidence interval [CI] 2.57–4.09), presence of visceral metastasis (Pooled HR: 1.84, 95% CI 1.42–2.38), presence of liver metastasis (Pooled HR: 4.23, 95% CI 2.18–8.20), higher neutrophil–lymphocyte ratio (NLR) (Pooled HR: 1.29, 95% CI 1.07–1.55) and, higher c-reactive protein (CRP) (Pooled HR: 2.49, 95% CI 1.52–4.07). Metastatic UC patients with poor PS, liver metastasis, higher pretreatment NLR and/or CRP have a worse survival despite pembrolizumab treatment. These findings might help to guide the prognostic tools for clinical decision-making; however, they should be interpreted carefully, owing to limitations regarding the retrospective nature of primary data. Supplementary Information The online version contains supplementary material available at 10.1007/s10147-021-02061-0.
Published: 2021
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35. Toxic Substance-induced Hippocampal Neurodegeneration in Rodents as Model of Alzheimer’s Dementia

Author: Dwi Cahyani Ratna Sari, Rina Susilowati, and Titis Nurmasitoh
Subjects: business.industry, Neurodegeneration, Morris water navigation task, General Medicine, Hippocampal formation, medicine.disease, Bioinformatics, medicine.disease_cause, Pathogenesis, Neurotrophic factors, medicine, Dementia, business, Pathological, Oxidative stress
Abstract: BACKGROUND: Alzheimer’s Dementia (AD) cases are increasing with the global elderly population. To study the part of the brain affected by AD, animal models for hippocampal degeneration are still necessary to better understand AD pathogenesis and develop treatment and prevention measures. AIM: This study was a systematic review of toxic substance-induced animal models of AD using the Morris Water Maze method in determining hippocampal-related memory impairment. Our aim was reviewing the methods of AD induction using toxic substances in laboratory rodents and evaluating the report of the AD biomarkers reported in the models. METHODS: Data were obtained from articles in the PubMed database, then compiled, categorized, and analyzed. Eighty studies published in the past 5 years were included for analysis. RESULTS AND DISCUSSION: The most widely used method was intracerebroventricular injection of amyloid-β _substances. However, some less technically challenging techniques using oral or intraperitoneal administration of other toxic substances also produce successful models. Instead of hippocampal neurodegeneration, many studies detected biomarkers of the AD pathological process while some reported inflammation, oxidative stress, neurotrophic factors, and changes of cholinergic activity. Female animals were underrepresented despite a high incidence of AD in women. CONCLUSION: Toxic substances may be used to develop AD animal models characterized with appropriate AD pathological markers. Characterization of methods with the most easy-handling techniques and more studies in female animal models should be encouraged.
Published: 2021
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36. Predictors for the risk and severity of post-thrombotic syndrome in vascular Behçet's disease

Author: Mehmet Ruhi Onur, Can Ilgin, Nuh Atas, Abdulsamet Erden, Seda Colak, Yasin Yıldız, Burcu Yağız, Ahmet Omma, Aysun Aksoy, Rabia Ergelen, Naile Bolca, Omer Karadag, Belkıs Nihan Coşkun, Fatma Alibaz-Oner, Ediz Dalkilic, Alper Sari, and Haner Direskeneli
Subjects: Adult, Male, medicine.medical_specialty, Deep vein, Azathioprine, macromolecular substances, Behcet's disease, 030204 cardiovascular system & hematology, Risk Assessment, Severity of Illness Index, Gastroenterology, Postthrombotic Syndrome, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, business.industry, Behcet Syndrome, Incidence (epidemiology), Middle Aged, Prognosis, medicine.disease, Thrombosis, stomatognathic diseases, Cross-Sectional Studies, medicine.anatomical_structure, Lower Extremity, Female, Surgery, Cardiology and Cardiovascular Medicine, Complication, business, Lower limbs venous ultrasonography, Post-thrombotic syndrome, medicine.drug
Abstract: Objective: Deep vein thrombosis (DVT) of the lower extremities is the most common form of vascular involvement in Behcet disease (BD), frequently leading to post-thrombotic syndrome (PTS) as a disabling complication. We have described the clinical characteristics and predictors of PTS presence among patients with BD and lower extremity DVT. We also used venous Doppler ultrasound (US) examinations in our assessment. Methods: Patients with BD (n = 205; 166 men, 39 women; age 39 6 9.5 years) and a history of DVT were investigated. The Villalta scale was used to assess the presence and severity of PTS. Doppler US examinations were performed within 1 week of the clinical evaluation. The total number of vessels with reflux, thrombi, recanalization, and collateral vessels were calculated. Results: Of the 205 patients with BD, 62% had had PTS and 18% had had severe PTS. Patients with PTS had had greater reflux (P = .054) and thrombosis (P = .02) scores compared with patients without PTS. Treatment with anticoagulation (AC), immunosuppressive (IS) therapy, or AC combined with IS drugs did not affect the occurrence of PTS. However, patients treated with IS therapy, with or without AC drugs, had a decreased incidence of severe PTS compared with the AC-only group (P = .017). Patients treated with AC plus IS agents also had increased collateral scores compared with patients treated with only IS drugs. Interferon-a use seemed to provide better recanalization scores compared with azathioprine only (1.0 [range, 0-14] vs 2.5 [range, 0-10]; P = .010). Conclusions: Patients with BD and DVT have a high risk of developing severe PTS. IS treatment decreases the development of severe PTS. AC therapy might influence the course of PTS by increasing the collateral scores, and the use of interferon-a also increased recanalization scores. Routine assessment with Doppler US examinations could be helpful in the prediction of severe PTS. (J Vasc Surg Venous Lymphat Disord 2021;9:1451-9.)
Published: 2021
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37. Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results

Author: Nagehan Didem Sari, Tolga Kırgezen, Istemi Serin, Mehmet Hilmi Dogu, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Dogu, Mehmet Hilmi
Subjects: medicine.medical_specialty, business.industry, hematology, fungal infection, Mucormycosis, Treatment results, medicine.disease, Dermatology, mucormycosis, medicine, Hematoloji, Medicine, Fungal Enfeksiyon, Mukormikoz, business
Abstract: Introduction: Mucormycosis is an aggressive-progressive invasive fungal infection caused by mold fungi in the division of mucorales of the zygomycetes class with high mortality, and is the most common fungal infection in patients with hematologic malignancies. Methods: This study retrospectively evaluated patients with mucormycosis diagnosis between January 2015 and December 2019, including demographic features, hematologic diseases and comorbidities, radiological evaluations, symptoms and signs, treatments, and outcomes. Results: Maxillofacial 9/19 (47.37%) of patients and 10/19 (59.9%) rhinoorbital mucor. Hematologic malignancy was observed in 15 (78.95%) patients, whereas others had additional pre-disposing factors, such as diabetes mellitus and chronic renal failure. The most common find-ings were persistent fever, mucopurulent nasal flux, and periorbital edema. Endoscopic sinus surgery + medication was administered in 12/19 (62.2%) patients and antifungal therapy in 7/19 (37.8%). In addition, 15/19 (79.95%) patients died and 4/19 recovered with sequela. Conclusion: The first large-scale mucormycosis study from our country will guide in determining the treatment algorithm. Effective and early surgery and antifungal application reduce mortality in mucormycosis by early diagnosis and multidisciplinary approach, without bone destruction in the paranasal sinus computed tomography with recurrent fever and earlystage sinusitis finding by performing a biopsy. Amaç: Mukormikoz, yüksek mortaliteye sahip zigomiset sınıfının mucorales bölümünde yer alan, küf mantarlarının neden olduğu agresif ilerleyen invaziv bir mantar enfeksiyonudur. Hematolojik maligniteli hastalarda en sık görülen mantar enfeksiyonu olarak karşımıza çıkmaktadır. Yöntemler: Çalışmamızda Ocak 2015-Aralık 2019 tarihleri arasında mukormikoz tanısı alan hastalar retrospektif olarak değerlendirildi. Hastaların demografik özellikleri, hematolojik hastalıkları ve komorbiditeleri, radyolojik değerlendirmeleri, semptom ve bulguları, tedavileri ve sonuçları değerlendirildi. Bulgular: Olgularımız 9/19 (%47,37) maksillofasiyal ve 10/19 (%59,9) rinoorbital mukor hastalarıydı. Hastaların 15’inde (%78,95) sadece hematolojik malignite varken, diğerlerinde diabetes mellitus ve kronik böbrek yetmezliği gibi ek predispozan faktörler vardı. En sık görülen bulgular inatçı ateş, mukopürülan burun akısı ve periorbital ödemdi. Hastaların 12/19’u (%62,2) endoskopik sinüs cerrahisi + antifungal tedavi ve 7/19’u (%37,8) sadece antifungal tedavi gördü. Hastaların 15/19’u (%79,95) öldü ve bunların 4/19’u sekel ile iyileşti. Sonuç: Ülkemizden ilk büyük ölçekli mukormikoz çalışması, tedavi algoritmasının belirlenmesi açısından yol gösterici olacaktır. Erken tanı ve multidisipliner yaklaşımla, etkili ve erken cerrahi ve antifungal uygulama ve biyopsi ile, mukormikozda mortalitenin, tekrarlayan ateş ile paranazal sinüs bilgisayarlı tomografide kemik destrüksiyonu olmaksızın, azaltılabileceğini düşünmekteyiz. WOS:000721618600001
Published: 2021

38. Dietary Soluble Fiber Improved Fecal Consistency in Burned Patients with Diarrhea

Author: Lily Indriani Octovia, Wina Sinaga, Ayu Diandra Sari, Aditya Wardhana, Evania Astella Setiawan, and Metta Satyani
Subjects: medicine.medical_specialty, business.industry, medicine.disease, Gastroenterology, Fecal consistency, Diarrhea, Bristol stool scale, Internal medicine, medicine, Soluble fiber, Medical nutrition therapy, medicine.symptom, business, Total body surface area, Dysbiosis, Barrier function
Abstract: Backgrounds: Diarrhea frequently occurs in severely burned patients attributable to impaired intestinal integrity and dysbiosis. Soluble fiber may improve intestinal barrier function, avoid bacterial translocation, then subsequently prevent and treat diarrhea. Soluble fiber is rapidly fermented by commensal bacteria and produces short-chain fatty acids (SCFA). Case Reports: A 51-year-old male with severe burn injury involving 53,5% total body surface area (TBSA) and diarrhea were given soluble fiber as part of his diet. Results: Administration of 6–10 g/d soluble fiber clinically improves stool consistency, assessed by Bristol Stool Scale, in the severely burned patient. The patient was discharged after 19 days of hospitalization with improvement in clinical condition. Summary: SCFA maintains intestinal integrity, supports the growth of commensal bacteria, and inhibits pathogens. There is no specific recommendation regarding fiber intake in burned patients
Published: 2021
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39. Penyebab Pneumonia pada Balita di Provinsi Sumatera Barat

Author: Oktavianis Oktavianis, Mila Sari, Nurhayati Nurhayati, and Fivie Bestrina
Subjects: education.field_of_study, business.industry, digestive, oral, and skin physiology, Population, Breastfeeding, medicine.disease, Spearman's rank correlation coefficient, Population density, Contagious disease, Pneumonia, medicine, Toddler, Immunization status, business, education, Demography
Abstract: Pneumonia toddlers is a contagious disease that are commonly found in West Sumatera Province. The purpose of this study is to determine causes of Pneumoniain Toddlers in the. The type of this study is analytic by using Spear Correlation with a non-reactive approach. The population is all sub-districts in West Sumatra Province; the samples are Pneumonia patient in toddlers in 80 sub-districts of 7 districts / cities. The results of the study shows that there is a correlation between population density (p = 0,000), exclusive breastfeeding (p = 0,000), immunization status (p = 0,000), healthy house (p = 0,000) and nutrition status (p = 0.018) toward Pneumoniain toddler in West Sumatra Province. But, there is no correlation between clean and healthy life behavior toward pneumonia.
Published: 2021
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40. A Retrospective Evaluation of Patients Hospitalized in the Internal Medicine Department at the Turkey Recep Tayyip Erdogan Somalia Mogadishu Training and Research Hospital

Author: Öznur Sari and Ahmed Muhammad Bashir
Subjects: General and Internal Medicine, business.industry, medicine, Somalia, CKD, DM, HT, internal diseases, intensive care, General Earth and Planetary Sciences, Medical emergency, medicine.disease, business, Genel ve Dahili Tıp, General Environmental Science
Abstract: Introduction: Data on patient diagnosis and treatment experiences are minimal in internal medicine clinics in Somalia. This study intends to examine the diagnostic distributions, demographic characteristics, and clinical effects of hospitalized patients treated at Mogadishu Somalia Turkey Recep Tayyip Erdogan Training and Research Hospital. Method: The demographic characteristics, diagnosis, duration of hospital stay and mortality rates of patients hospitalized at Turkey Recep Tayyip Erdogan Somalia Mogadishu Training and Research Hospital between January 2017 and June 2019 were analyzed. Results: The study included 3,246 patients, 1,759 (54.2%) males and 1,487 (45.8%) females with an average age of 50.82±19.25 (18-101) years. When evaluating hospitalization indications, the most common causes of hospitalization were chronic (29.4%) and acute kidney failure (14.8%) and other complications associated with these conditions. Other important diseases requiring hospitalization were diabetes mellitus-related conditions (11.9%), anemia (5.2%), hypertensive complications (3.5%), respiratory diseases (4.2%), contagious hepatitis (2.1%), cancer-related hospitalization situations (3.6%), infectious diseases (3.3%), respiratory diseases (3%), and cardiovascular diseases (3%). Patient mortality rates were 38.6% in the general intensive care unit, 35.9% in emergency intensive care unit and 25.5% in the internal medicine department. Higher mortality rates were observed in emergency and general intensive care patients relative to patients in the internal medicine ward [OR:7.4 (5.7-9.7), OR: 10.4 (8.2-13.3)]. Conclusion: In fragile healthcare systems like Somalia, morbidity and mortality are very high, and potential implementation of successful primary care management plans will dramatically minimize the burden associated with healthcare by reducing the incidence and severity of CKD, DM, HT, and CVD.
Published: 2021
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41. Sunkist Peel Ethanol Extract Ameliorates Diabetic Nephropathy in Streptozotocin-Induced Diabetic Wistar Rats

Author: OK Yulizal, Maya Sari, and Chrismis Novalinda Ginting
Subjects: Diabetic nephropathy, chemistry.chemical_compound, Ethanol, chemistry, business.industry, Medicine, General Medicine, Pharmacology, business, medicine.disease, Streptozotocin, medicine.drug
Abstract: Background: Kidney disorders in diabetic patients can gradually fall into end-stage kidney disease (ESKD) which can greatly interfere with the person's quality of life, in developed countries about 50% of patients with ESKD are caused by diabetes. On the other hand, various studies on citrus fruits have been performed to explore its pharmacological benefits. Aim: this study was aimed to explore the benefits of Sunkist orange peel ethanol extract against diabetic nephropathy in wistar rats as animals’ trial. Methods: This study was used 25 rats and was divided into five groups: viz. control, standard, Sunkist Peel Ethanol Extract-I, II, and III (500, 750, and 1500 mg/kg BW). After 28 days of intervention, BUN and Creatinine levels were measured in all rats. Meanwhile, data analysis used is parametric statistics in the form of One-Way ANOVA with alternative analysis in the form of the Kruskal Wallis test. Results: This study showed that the Sunkist peels ethanol extract significantly decreased BUN (P-Value < 0.05) and creatinine (P-Value < 0.05) level. The highest dosage of extract did not show a significant difference in BUN level against standard group. Conclusion: Overall, it can be concluded that the Sunkist peel ethanol extract has kidney protection effect against diabetic nephropathy at highest dosage (1500 mg/ kg BW).
Published: 2021
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42. PENGARUH EDUKASI MEDIA BOOKLET TERHADAP PENGETAHUAN DAN SIKAP ORANG TUA TENTANG IMUNISASI DASAR PADA MASA PANDEMI COVID-19

Author: Wahyudi Wahyudi, Sari Wahyunita, Aesty Rahayu, and Eny Hastuti Hastuti
Subjects: Research design, medicine.medical_specialty, business.industry, Tetanus, Diphtheria, medicine.disease, Rubella, Measles, Immunization, Family medicine, Health care, Pandemic, medicine, business
Abstract: The Indonesian government is taking several steps to ensure the control of COVID-19 and strengthen the capacity of the health care system to handle the pandemic period. One of them is the coverage of basic immunization to prevent diseases in children such as measles, rubella, and diphtheria which is decreasing, including the number of immunization coverage for diphtheria, pertussis, tetanus (DPT3) and measles and rubella (MR1) has decreased by more than 35%. Immunization services are reopened to prevent Extraordinary Events (KLB) of diseases in children that can be prevented by immunization (PD3I), to socialize a series of guidelines, standard operating procedures (SOP), as well as communication, information, and education (KIE). This study aims to determine the effect of booklet media education on parents' knowledge and attitudes towards basic immunization during the COVID-19 pandemic. Research Design Nonrandomized pre-test post-test with control group design. The total sample of 158 respondents was divided into 2 groups, the intervention group which was educated with booklet media and the control group without booklet education. The results showed that booklet media education was very influential (p = 0.001) on parents' knowledge and attitudes about basic immunization during the COVID-19 pandemic, this proves that booklet media is a communication tool that can be used by health workers to help increase parents' knowledge so as not to worry about bringing children to health services to keep immunizing during this COVID-19 pandemic.
Published: 2021
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43. <scp>HPV</scp> ‐Positive Status Is an Independent Factor Associated With Sinonasal Inverted Papilloma Recurrence

Author: Eeva Auvinen, Jaana Hagström, Sanna Viitasalo, Sari Hammarén-Malmi, Joakim Dillner, Taru Ilmarinen, Maija Hytönen, Markus Lilja, and Leena-Maija Aaltonen
Subjects: medicine.medical_specialty, Nose Neoplasms, Inverted papilloma, Alphapapillomavirus, Gastroenterology, Resection, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Sinonasal inverted papilloma, parasitic diseases, medicine, Humans, Prospective Studies, Human papillomavirus, 030223 otorhinolaryngology, Prospective cohort study, Papillomaviridae, Papilloma, Inverted, integumentary system, business.industry, HPV Positive, Papillomavirus Infections, virus diseases, medicine.disease, female genital diseases and pregnancy complications, Independent factor, 3. Good health, Increased risk, Otorhinolaryngology, 030220 oncology & carcinogenesis, Neoplasm Recurrence, Local, business, Paranasal Sinus Neoplasms
Abstract: Objectives The present study aimed to evaluate human papillomavirus (HPV) occurrence in sinonasal inverted papilloma (SNIP), and to assess factors associated with HPV positivity and SNIP recurrence. Study design Prospective study. Methods We prospectively collected clinical data and fresh tissue specimens from 90 consecutive patients treated for SNIP at Helsinki University Hospital, between 2015 and 2019. Fourteen patients with recurrent SNIP underwent repeated tumor sampling. All tissue specimens were analyzed for the presence of HPV. Factors associated with SNIP recurrence and HPV positivity were assessed. Results Among 107 SNIP specimens, 14 (13.1%) were positive for low-risk HPV and 6 (5.6%) were positive for high-risk HPV. HPV positivity was associated with an increased risk of recurrence (P = .004). Smoking was significantly associated with HPV positivity in SNIP (P = .01), but a history of HPV-related diseases or patient sexual habits did not correlate with HPV positivity. The recurrence rate was lower among patients with SNIP that underwent an attachment-oriented resection, compared to patients treated without attachment-oriented resections (78.6% vs 25.8%, P Conclusions The risk of SNIP recurrence was highly associated with 1) HPV positivity and 2) surgery without an attachment-oriented resection. Oncogenic HPV was rare in SNIP. Level of evidence 3 Laryngoscope, 2021.
Published: 2021
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44. Perbedaan Efektifitas Breathing exercise dan Batuk Efektif terhadap Peningkatan Ekspansi Paru Penderita TB Paru

Author: Setiadi Setiadi, Nisha Dharmayanti Rinarto, and Ninik Ambar Sari
Subjects: Research design, medicine.medical_specialty, education.field_of_study, Lung, Tuberculosis, business.industry, Population, medicine.disease, medicine.anatomical_structure, Pulmonary tuberculosis, Internal medicine, measurement_unit.measuring_instrument, medicine, Respiratory system, education, business, Peak flow meter, Aromatherapy, measurement_unit
Abstract: Introduction: Pulmonary TB is a contagious disease in the respiratory system caused by the bacterium Mycobacteria tuberculosis. The purpose of this research is to analyze the difference in the effectiveness of breathing exercise and effective cough to increase lung expansion of pulmonary tuberculosis patients. Objectives: the purpose of this research is to analyze the difference in the effectiveness of breathing exercise and effective cough to increase lung expansion of pulmonary tuberculosis patients. Methods: The research design used Quasy experiment with a Pre-postes approach with a control group design. The population of this research was pulmonary TB patients at Perak Timur Surabaya Public Health Center amounting to 33 people. The sampling technique used Probability Sampling with Simple Random Sampling got a sample of 30 people. Independent variables were aromatherapy eucalyptus oil and breathing exercises. The dependent variable was pulmonary expansion in pulmonary tuberculosis patients. Instrumen in this research used Peak Flow Meter and an observation sheet. Data analysis used the One Way Annova Test. One Way Annova test results showed that breathing exercise was more effective when compared with aromatherapy eucalyptus oil in influencing the process of increasing pulmonary expansion in patients with pulmonary tuberculosis. Results: Results of aromatherapy analysis of eucalyptus oil with pulmonary expansion ρ = 0,530 (ρ ˃ α = 0,05), and breathing exercise with pulmonary expansion ρ = 0.026 (ρ < α = 0,05. Conclusions: The implications of the study show that breathing exercise is more effective for non pharmacology therapy to help increase lung expansion in patients with pulmonary tuberculosis so as to reduce shortness of breath.
Published: 2021
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45. The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice

Author: Desi R. Sari, Ismi D. Meiliana, Deandra Maharani Widiatmaja, Minidian Fasitasari, Purwo Sri Rejeki, Yoshio Yamaoka, Hamidah Kurniasari, and Alif Lutvyani
Subjects: Male, medicine.medical_specialty, Physiology, medicine.medical_treatment, Mice, Insulin-like growth factor, Diabetes mellitus, Internal medicine, Drug Discovery, medicine, Animals, Humans, Obesity, Insulin-Like Growth Factor I, Correlation test, Noncommunicable Diseases, Serum adiponectin, Pharmacology, Adiponectin, business.industry, General Medicine, medicine.disease, Endocrinology, Noncommunicable disease, Diet, Ketogenic, business, Ketogenic diet
Abstract: Objectives Noncommunicable disease (NCD) including obesity, cancer, and diabetes has become particular concern worldwide due to its morbidity and mortality which keep increasing annually. Adiponectin and insulin-like growth factor-1 (IGF-1) are known to be substances that are involved in the development of NCD. Several diet regimens have been developed to treat NCD, one of which is the ketogenic diet (KD). This study aimed to analyze the long-term KD effect on serum adiponectin and IGF-1 levels in mice. Methods This study was a real experimental with post-test only controls group design. The subjects were 14 male mice (2–3 months, 20–30 g) were randomly divided into two groups, K1 (n=7, standard diet) and K2 (n=7, KD with a composition of 60% fat, 30% protein, and 10% fiber). All subjects were given diet intervention for 8 weeks ad libitum. Serum adiponectin and IGF levels were measured in post-intervention using Enzyme-Linked Immunosorbent Assay. Distribution of normality was analyzed by the Shapiro–Wilk Test, mean difference using Independent T-Test, and linear correlation using Pearson’s Correlation Test. Data analysis was performed using Statistic Package for Social Science Version 16. Results Serum adiponectin levels in K1 (0.080 ± 0.012) pg/mL and K2 (0.099 ± 0.005) pg/mL, with p=0.003. Serum IGF-1 levels in K1 (133.535 ± 25.702) ng/mL and K2 (109.987 ± 27.118) ng/mL, with p=0.121. Coefficient correlation between serum adiponectin and serum IGF-1 levels [r]=−0.401, with p=0.155. Conclusions Long-term KD increases serum adiponectin levels and has no effect on serum IGF-1 levels. There was no significant correlation between serum adiponectin and serum IGF-1 levels.
Published: 2021
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46. Self-concept Factor Influencing Antenatal Provider Selection: A Qualitative Study from Indonesian Midwives

Author: Amadea Zulfiah Azmi, Nur Anisah Rahmawati, Budi Prasetyo, Erni Rosita Dewi, Vita Ratna Sari, and Dwi Izzati
Subjects: Pregnancy, business.industry, Self-concept, General Medicine, medicine.disease, Nonprobability sampling, Nursing, medicine, Childbirth, Thematic analysis, Duration (project management), business, Reproductive health, Qualitative research
Abstract: Background: The different philosophies of care between midwives and obstetricians influence maternal health services. Midwives deliver a holistic physiological approach, while obstetricians implement a medical approach and a technocratic model. Different perspectives in interpreting professional philosophies may impact the choices of antenatal providers for midwives, themselves. This study aims to determine the self-concept of Indonesian midwives in interpreting professional philosophy regarding the decision-making of the antenatal provider during pregnancies. Materials and Methods: A qualitative descriptive with a phenomenological approach was carried out. It used a purposive sampling method. This study involves 15 midwives who are still active in providing services in private midwifery practices, primary health centers, and hospitals that had experienced pregnancy. The variable was the perspective of midwives in choosing ANC providers considering the self-concept. Data obtained by in-depth interview technique for 60-90 minutes duration and is analyzed using thematic analysis techniques. Results: As the results, the selection of ANC providers has been shaped by the self-concept factor. Most perspectives are influenced by (1) knowledge of the physiological and high-risk of pregnancy concept (2) previous experiences in pregnancy/ childbirth/ after birth (3) role in families when addressing reproductive health decisions. Conversely, education level and work experiences did not affect the option to have antenatal care. Conclusion: Self-concept influences midwives’ perspective of making decisions about ANC providers. This study shows there is a limited understanding of the philosophy of midwifery care which reflects on the decision-making of the midwives in regard to the care received during the pregnancy.
Published: 2021
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47. Subacute lower extremity arterial thrombosis; early outcomes of catheter directed thrombolysis with alteplase and importance of malnutrition assessed by CONUT score

Author: Selçuk Pala, Zeynep Esra Güner, Hacer Ceren Tokgoz, Gökhan Alıcı, Ali Karagöz, Serdar Fidan, Birol Özkan, Ugur Arslantas, Ender Özgün Çakmak, Mehmet Aytürk, Elnur Alizade, Munevver Sari, and Fatih Yilmaz
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Nutritional Status, Severity of Illness Index, Peripheral Arterial Disease, Fibrinolytic Agents, Internal medicine, Catheterization, Peripheral, medicine, Diseases of the circulatory (Cardiovascular) system, Humans, Thrombolytic Therapy, Myocardial infarction, Aged, Retrospective Studies, business.industry, Mortality rate, Malnutrition, Thrombosis, Retrospective cohort study, Thrombolysis, Middle Aged, medicine.disease, RC31-1245, Treatment Outcome, Lower Extremity, Amputation, RC666-701, Tissue Plasminogen Activator, Medicine, Female, business, TIMI
Abstract: Objective In this study, we aimed to report early outcomes of catheter-directed thrombolysis (CDT) with alteplase in patients with subacute limb ischemia and to assess whether there is a link between malnutrition (determined by Controlling Nutritional Status [CONUT] score) and response to thrombolysis and bleeding. Methods This was a retrospective study conducted between 2007 and 2020 with 118 patients with Rutherford class 3 (34.7%), class 4 (40.7%), and class 5 (24.6%) symptoms owing to infraaortic subacute thrombotic occlusion who were treated with catheter-directed thrombolysis. Results Immediate technical success (Thrombolysis in Myocardial Infarction [TIMI] grade 2/3) was achieved in 56%, overall technical success after all adjunctive procedures was seen in 83.9%. Clinical success was obtained in 74.5% within 30 days. Major bleeding occurred in 11.8%. When we excluded access site hematomas, the rate of major bleeding was 5.1%. In-hospital mortality rate was 5.1%, and the amputation rate within 30 days was 12.7%. Any-degree malnutrition was detected in 48.3% according to CONUT score (≥2). Any-degree malnutrition was associated with failed thrombolysis and bleeding. The CONUT score predicted insufficient lytic response even after adjustment for confounding factors; however, serum C-reactive protein or neutrophil/lenfosit ratio did not. Other predictors of immediate technical failure after thrombolysis were symptom duration, Rutherford class 4/5 symptoms, and worsened distal runoff. Conclusion In patients with subacute limb ischemia, CDT combined with adjunctive interventions was effective in many patients at the expense of a substantial risk of bleeding and death. Malnutrition was associated with insufficient lytic response and bleeding. Physicians should be aware of malnutrition and consider the nutritional status of patients with limb ischemia when selecting appropriate treatment.
Published: 2021
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48. The Role of Sex, Ethnicity, Age, and Nutritional Status in the Seropositivity of the Measles Vaccine

Author: I Wayan Arsana Wiyasa, Wisnu Barlianto, Novilia Sjafri Bachtiar, Tita Luthfia Sari, H. R. Teni Nurlatifah, and H.M.S. Chandra Kusuma
Subjects: biology, business.industry, Ethnic group, General Medicine, medicine.disease, Measles, Vaccination, Immunization, biology.protein, Medicine, Observational study, Measles vaccine, Seroconversion, Antibody, business, Demography
Abstract: AIM: This study investigates the relationship between sex, ethnicity, age, nutritional status with the seropositivity of the Edmonston-Zagreb vaccine in children. METHODS: A cross sectional, observational study was conducted. A total of 45 children were differentiated based on sex, ethnicity, age, and nutritional status when they received the Edmonston-Zagreb measle vaccine for the first time. Flow cytometry was used to look at differences in antibody status as well as populations of CD-4 and CD-8 cells that release IFN- γ. RESULTS: We found no significant differences in antibody levels or CD-4 and CD-8 cell populations that secrete IFN- γ between boys and girls (p > 0.05). Besides, similar results were also confirmed in comparisons between Javanese and Sundanese ethnic groups, 9 months versus more than 9 months of age, or normal versus low body mass index (p > 0.05). CONCLUSIONS: We conclude that sex, race, age, and nutritional status had no effect on immune response to vaccination. As a result, there was no barrier to seroconversion and optimal immunological performance in the children in this trial who received the Edmonston-Zagreb measles vaccination.
Published: 2021
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49. Rare Case of Multiple Lineage Dysplasia Myelodysplastic Syndrome Presenting with Only Anemia: A Case Report

Author: Agus Susanto Kosasih, Lyana Setiawan, Resti Mulya Sari, Ikhwan Rinaldi, Noorwati Sutandyo, and Kevin Winston
Subjects: Pathology, medicine.medical_specialty, Lineage (genetic), Dysplasia, Anemia, business.industry, hemic and lymphatic diseases, Rare case, medicine, General Medicine, medicine.disease, business
Abstract: BACKGROUND: Myelodysplastic syndrome (MDS) is a heterogeneous group of hematopoietic stem cell disorders which is characterized by ineffective hematopoiesis and risk of progression into acute myeloid leukemia. The diagnosis and classification of MDS are determined from the findings of dysplasia in one or more cell lineage and the percentage of blast cell on bone marrow examination. However, it should be noted that an abnormality in one marrow cell lineage does not necessarily translate to the corresponding clinical phenotype. Here, we present a case of MDS with multilineage dysplasia (MLD) (erythrocyte, leukocyte, and thrombocyte) from bone marrow aspiration, but with anemia as the sole clinical manifestation (single cytopenia). CASE REPORT: A 78-year-old male patient came to our clinic on July 10, 2020, with chief complaint of worsening fatigue which started approximately 1 year before visit. His vital signs during the visit were stable and no other abnormalities observed other than pale conjunctivae. Complete blood count showed macrocytic anemia with no abnormalities in leukocyte count and thrombocyte count, which suggested a single cytopenia. Peripheral blood smear was negative for megaloblasts and hypersegmented neutrophils. The patient’s bone marrow examination showed MDS with MLD. This result was in contrast to complete blood count examination which only showed anemia (single cytopenia). CONCLUSION: This case showed that there could be discrepancy between clinical manifestations of the cytopenia with bone marrow dysplasia, which highlighted the importance of conducting bone marrow examination to properly classify MDS type.
Published: 2021
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50. PREEKLAMSIA BERAT PADA IBU HAMIL DI RSUD RADEN MATTAHER JAMBI

Author: Lia Artika Sari, Diniyati Diniyati, and Ayu Nurma Afriyanti
Subjects: Pregnancy, education.field_of_study, medicine.medical_specialty, Cross-sectional study, Obstetrics, business.industry, Medical record, Incidence (epidemiology), Population, medicine.disease, Preeclampsia, medicine, Childbirth, General hospital, education, business
Abstract: Latar Belakang Usia yang dipandang memiliki risiko saat melahirkan adalah di bawah 20 tahun dan di atas 35 tahun. Sedangkan antara 20-35 tahun dari segi usia merupakan usia reproduksi sehat dengan risiko melahirkannya minimal, ibu yang memiliki riwayat kehamilan dengan preeklampsi akan berisiko sebesar 8,81 kali lebih besar untuk hamil kembali dengan preeklamsi di bandingkan dengan ibu yang tidak memiliki riwayat preeklampsi.. Metode: Penelitian kuantitatif dengan desain cross sectional yang bertujuan untuk mengetahui faktor- faktor yang berhubungan dengan kejadian preeklamsia berat pada ibu hamil di RSUD Raden Mattaher Provinsi Jambi. Populasi pada penelitian ini adalah seluruh ibu hamil yang berkunjung ke RSUD Raden Mattaher Provinsi Jambi tahun 2018 . Tehnik sampel dengan Total Sampling yaitu sebanyak 122 ibu hamil yang mengalami preeklamsi berat. Penelitian ini dilakukan di RSUD Raden Mattaher Jambi dari tanggal 17 juni s/d 4 Juli 2019. Data pada penelitian ini menggunakan data sekunder berupa data rekam medik di RSUD Raden Mattaher tahun 2018. Analisis yang digunakan pada penelitian ini adalah univariat dan bivariat dan dianalisis dengan chi-square Hasil: semua variabel berhubungan yaitu ada hubungan antara usia ibu hamil dengan preeklampsia dengan p-value 0.000, ada hubungan antara karakteristik paritas ibu bersalin dengan preeklampsia dengan p-value 0.000 ada hubungan antara gravida ibu dengan kasus preeklampsia dengan p-value 0.004.. Kesimpulan: Ada hubungan antara usia ibu hamil dengan preeklampsia. ada hubungan antara karakteristik paritas ibu bersalin dengan preeklampsia dengan p-value 0.000 ada hubungan antara gravida ibu dengan kasus preeklampsia.
Published: 2021
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