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Tularemia is a bacterial zoonosis which is commonly transmitted through tick or insect bites or contact with meat of infected animals. We report the case of a 36-year-old man who developed fever, chills, headaches, and a painful, unilateral, inguinal lymphadenopathy with a red-livid skin discoloration after an insect bite on his abdomen. Ulceroglandular tularemia was diagnosed through polymerase chain reaction (PCR) and serology. Treatment with doxycycline for 21 days resulted in an excellent outcome.

Preeclampsia (PE) is a complex disorder that affects 3-5% of all pregnancies and is a leading cause of maternal and fetal morbidity and mortality. To date, the heterogeneity of clinical presentation, disease severity and outcomes have limited significant advances in early prediction, diagnosis, and therapeutic intervention of PE. The rapidly expanding field of metabolomics, which has the capacity to quantitatively detect low molecular weight compounds (metabolites) in tissue and biological fluids, shows tremendous promise in gaining a better understanding of PE. This review will discuss this emerging field and its contribution to recent advances in the understanding of PE pathophysiology, and identification of early predictive metabolic biomarkers for this complex disorder.

Background: Artificial reproductive technique - in vitro fertilization (IVF) has taken an important place in medicine as a routine and efficient method for the treatment of fertility. Aim: To examine outcome in newborns from pregnancies after IVF. Methods: A retrospective study included 260 newborns from pregnancies after IVF, which were divided into two groups. The first group consisted of 136 neonates from monofoetal IVF pregnancies and the second group consisted of 124 neonates from multifoetal IVF pregnancies. In newborns were analyzed: gender, gestation, anthropometric measures, Apgar score, morbidity and outcome. Results: The study found no difference in sex distribution between both groups of newborns from IVF pregnancies (p>0.05). Analysis found a significantly higher gestational age (37.6gw vs. 35.0gw, p< 0.01), lower rate of prematurity (20.5% vs. 64.5%, p< 0.01), greater birth body weight (3098.5g vs. 2238.7g, p< 0.01) and body length (49.9cm vs. 45.5cm, p< 0.01) in neonates from monofoetal IVF pregnancies. Analysis found significantly higher values of Apgar score at the first (8.5 vs. 7.0, p< 0.01) and at the fifth minute (9.3 vs. 7.8, p< 0.01) of birth in newborns from monofoetal IVF pregnancies. Testing has found a significantly lower morbidity in the first group of neonates (40.4% vs. 71.8%, p< 0.01), respectively, higher number of newborns from monofoetal IVF pregnancies had a favorable outcome (89.7% vs. 59.6%, p< 0.01). Conclusion: Newborns from monofoetal IVF pregnancies have a lower potential risk of perinatal complications with lower morbidity and better outcome, unlike newborns from multifoetal IVF pregnancies.