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1. Outcomes of urgent aortic wrapping for acute type A aortic dissection

Author: Ramzi Ramadan, Sébastien Multon, Vincenzo Vento, Philippe Deleuze, Dominique Fabre, Stéphan Haulon, and Julien Guihaire
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Aorta, Thoracic, 030204 cardiovascular system & hematology, Blood Vessel Prosthesis Implantation, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, medicine.artery, Ascending aorta, medicine, Humans, Thoracic aorta, Aorta, Aged, Retrospective Studies, Computed tomography angiography, Aortic dissection, Aortic Aneurysm, Thoracic, medicine.diagnostic_test, business.industry, Mortality rate, Endovascular Procedures, Retrospective cohort study, Irad, medicine.disease, Surgery, Aortic Dissection, Treatment Outcome, 030228 respiratory system, cardiovascular system, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business
Abstract: Objective Standard surgical repair of acute type A aortic dissection is associated with high mortality rates, especially in high-risk patients. In an attempt to improve survival in frail patients, we evaluated the outcomes after ascending aorta wrapping in a high-risk patient cohort. Methods This single-center retrospective cohort study included all consecutive patients treated using ascending aorta wrapping for an acute type A aortic dissection from 2008 to 2019. The primary end points included 30-day mortality, survival during follow-up, and dissection-related mortality. Secondary end points included assessment of aortic remodeling after ascending aorta wrapping. Patients with an aortic anatomy suitable for adjunctive endografting of the ascending aorta were also identified. Results Thirty-five consecutive patients who underwent ascending aorta wrapping were included. Their median age was 77 years (range, 46-96 years). The 30-day all-cause mortality rate was 9%. Major complications occurred in 7 patients (21%), including early reinterventions in 11 (31%). Median follow-up was 36 months (range, 2.4-106.6; interquartile range, 72). The actuarial survival at 36 months was 82%. The dissection-related mortality was 11.4%. The median aortic growth of the nonwrapped descending thoracic aorta was 3.4 mm. Computed tomography scan analysis depicted that 88% of survivors were theoretical candidates for an additional endovascular procedure to exclude the primary entry tear. Conclusions Aortic wrapping is associated with favorable early outcomes and a low rate of aortic events during follow-up. This therapeutic option should be considered for patients considered too fragile for standard surgical repair.
Published: 2022
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2. Uncommon traumatic anterior aortic dissection in the context of a blunt trauma

Author: Angelo La Valle, Michael Hall, Ramzi Freij, and A Brooks
Subjects: Aortic dissection, medicine.medical_specialty, medicine.diagnostic_test, Images In…, business.industry, Major trauma, General surgery, Context (language use), Interventional radiology, General Medicine, medicine.disease, Wounds, Nonpenetrating, Aortic Dissection, Blunt trauma, medicine, Humans, business, Motor vehicle crash
Abstract: This 79-year-old woman was involved in a road traffic collision in which another driver rear-ended her stationary car at a speed of around 70 m/h. She was transferred to the nearest Major Trauma Centre, where her observations remained stable and initial primary survey was unremarkable. She had a
Published: 2023

3. Impact of white blood cell count on clinical outcomes in patients treated with aspirin-free ticagrelor monotherapy after percutaneous coronary intervention

Author: Mathias Vrolix, Joanna J. Wykrzykowska, Rutao Wang, Wolfgang Koenig, Ply Chichareon, Hironori Hara, Patrick W. Serruys, Chao Gao, Kurt Huber, Ramzi Khamis, Christian W. Hamm, Yoshinobu Onuma, Mariusz Tomaniak, Jan J. Piek, Masafumi Ono, Philippe Gabriel Steg, Global Leaders Study Investigators, Ranil de Silva, Hideyuki Kawashima, Stephan Windecker, Robert F. Storey, Pawel Jasionowicz, Peter Jüni, Cardiology, Graduate School, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, and ACS - Heart failure & arrhythmias
Subjects: Ticagrelor, medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, Lower risk, Percutaneous coronary intervention, Leukocyte Count, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Clinical endpoint, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Myocardial infarction, White blood cell, Inflammation, Aspirin, Ticagrelor monotherapy, business.industry, Hazard ratio, Leucocyte, medicine.disease, Treatment Outcome, Conventional PCI, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract: Aims The aim of this study was to investigate the efficacy and safety of ticagrelor monotherapy in patients undergoing percutaneous coronary intervention (PCI) stratified according to the baseline white blood cell (WBC) count. Methods and results This is a post hoc analysis of the GLOBAL LEADERS trial, a multi-centre, open-label, randomized all-comer trial in patients undergoing PCI, comparing the experimental strategy (23-month ticagrelor monotherapy following 1-month dual anti-platelet therapy [DAPT]) with the reference strategy (12-month aspirin monotherapy following 12-month DAPT). Patients were stratified into two WBC groups, either < or ≥median WBC count of 7.8 × 109 cells/L (lower or higher WBC group, respectively). The primary endpoint was a composite of all-cause mortality or new Q-wave myocardial infarction at 2 years. Of 14 576 patients included in the present study, 7212 patients (49.5%) were classified as the lower WBC group, who had a significantly lower risk of both ischaemic and bleeding outcomes at 2 years. At 2 years, the experimental strategy was associated with a significant lower incidence of the primary endpoint compared with the reference strategy in the lower WBC group [2.8% vs. 4.2%; hazard ratio (HR): 0.67; 95% confidence interval (CI): 0.52–0.86] but not in the higher WBC group (4.8% vs. 4.7%; HR: 1.01; 95% CI: 0.82–1.25; Pinteraction=0.013). There were no significant differences in the risks of Bleeding Academic Research Consortium type 3 or 5 bleeding between two anti-platelet strategies regardless of the WBC groups. Conclusion Increased WBC counts, which may reflect degree of inflammation, at the time of index procedure may attenuate the anti-ischaemic benefits of ticagrelor monotherapy observed in patients with lower WBC counts.
Published: 2022
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4. Human Papillomavirus Vaccination and Human Papillomavirus–Associated Cancer Rates Within Florida Counties

Author: Natalie L. Silver, Jaclyn Hall, Yi Guo, Lindsay A. Thompson, Sarah M. Rothbard, Stephanie A. S. Staras, Ramzi G. Salloum, Elizabeth Shenkman, Tianyao Huo, Hee D. Cho, and Eric Richardson
Subjects: Male, Adolescent, Epidemiology, Population, Immunization registry, Psychological intervention, Alphapapillomavirus, Human papillomavirus vaccine, Neoplasms, Humans, Medicine, Papillomavirus Vaccines, Human papillomavirus, education, Papillomaviridae, education.field_of_study, business.industry, Papillomavirus Infections, Vaccination, Public Health, Environmental and Occupational Health, Cancer, medicine.disease, Human papillomavirus vaccination, Florida, Female, Immunization, business, Demography
Abstract: Introduction To direct interventions, the Florida counties with the greatest risk of current and future human papillomavirus‒associated cancers were identified by estimating county-level (1) percentages of adolescents aged 13–17 years who initiated (≥1 dose) and were up to date (2–3 doses) for the human papillomavirus vaccine and (2) human papillomavirus‒associated cancer incidence rates. Methods Records were obtained for human papillomavirus vaccinations from the Florida immunization registry (2006–2019), incident cancer cases from the Florida registry (2013–2017), and annual population counts from the Florida Department of Health (2006–2019). In 2020, annual county-level human papillomavirus vaccine initiation, human papillomavirus vaccine up-to-date, and age-adjusted human papillomavirus‒associated cancer incidence rates were estimated. Results Among adolescents aged 13–17 years, average 2018–2019 county-specific human papillomavirus vaccine initiation ranged from 38% to 100% for females and from 34% to 96% for males. Up-to-date estimates ranged from 20% to 72% for females and from 24% to 77% for males. The majority (78%) of counties with initiation and up-to-date estimates within the lowest tercile were located in Northern Florida. County-specific 2013–2017 annualized, adjusted human papillomavirus‒associated cancer incidence rates ranged from 0 to 29.8 per 100,000 among females and from 5.4 to 24.1 per 100,000 among males. Counties within the highest tercile for human papillomavirus‒associated cancers were primarily (90% for females and 77% for males) located in Northern Florida. Conclusions Human papillomavirus‒associated cancer risk varies widely across Florida counties, with particularly high risk within Northern Florida. Targeting interventions toward counties with low vaccination and high cancer rates may reduce human papillomavirus‒associated cancers.
Published: 2021
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5. Self-rated familiarity with autism spectrum disorders among practicing nurses: a cross-sectional study in the palestinian nursing practice

Author: Ramzi Shawahna
Subjects: medicine.medical_specialty, Palestine, Cross-sectional study, Psychological intervention, RT1-120, Nurses, Nursing, behavioral disciplines and activities, mental disorders, medicine, Early childhood, Autism spectrum disorder, Nursing management, Curriculum, General Nursing, business.industry, Nursing research, Research, Familiarity, medicine.disease, Knowledge, Family medicine, Autism, business
Abstract: Background Autism spectrum disorders (ASDs) are one of the most prevalent neurodevelopmental disabilities of early childhood. Practicing nurses are in a key position to help patients with ASDs and/or their caregivers/families. This study was conducted to assess self-rated familiarity with ASDs among practicing nurses in Palestine. The study also aimed to identify the sociodemographic and practice variables that could predict high self-rated familiarity scores. Methods This was a cross-sectional study using a questionnaire. The study was conducted in the period between January 2019 and May 2019. The questionnaire collected: 1) the sociodemographic, pedagogic, and practice variables of the nurses, 2) their self-rated familiarity with signs and symptoms, treatment options, and community resources of ASDs, 3) their self-rated confidence in their abilities to provide counseling for parents/family/caregivers on the drugs prescribed for children/patients with ASDs and their potential adverse effects, and 4) their willingness to receive education/training on issues in ASDs. Results The questionnaire was completed by 357 practicing nurses. The practicing nurses self-reported inadequate familiarity with symptoms, treatment, and community resources of ASDs. The mean familiarity score was 35.8% (SD: 18.9%). The nurses also expressed low confidence in their ability to provide counseling services to caregivers/families of children with ASDs. About 75% of the nurses agreed that they could benefit from taking a continuing educational/training program in the area of ASDs and about 82% of the nurses agreed that the nursing school curriculum should include courses in the area of ASDs. The multiple linear regression model showed that higher familiarity scores were predicted by having longer practical experience, having a higher academic degree in nursing, and having a continuing educational course/program on ASDs. Conclusion Findings of this study highlighted inadequate familiarity with issues of ASDs among practicing nurses. Higher familiarity was predicted by the length of practical experience, higher academic degree in nursing, and having continuing educational course/program on ASDs. Specifically designed pedagogic interventions might be helpful in increasing familiarity of practicing nurses on ASDs. More investigations are still needed to evaluate if these interventions can improve familiarity and services provided to patients with ASDs.
Published: 2021

6. Combination of Low-Dose, Short-Course Mycophenolate Mofetil With Cyclosporine and Methotrexate for Graft-Versus-Host Disease Prophylaxis in Allogeneic Stem Cell Transplant

Author: Mani Ramzi, Hourvash Haghighinejad, Nasrin Namdari, and Shirin Haghighat
Subjects: medicine.medical_specialty, Graft vs Host Disease, Mycophenolate, Gastroenterology, law.invention, Randomized controlled trial, HLA Antigens, law, Internal medicine, medicine, Humans, Prospective Studies, Transplantation, Acute leukemia, business.industry, Incidence (epidemiology), Hematopoietic Stem Cell Transplantation, Mycophenolic Acid, medicine.disease, Leukemia, Myeloid, Acute, Regimen, Methotrexate, Treatment Outcome, Graft-versus-host disease, Cyclosporine, Stem cell, business, Immunosuppressive Agents, Stem Cell Transplantation, medicine.drug
Abstract: OBJECTIVES With the standard regimen for graft-versushost disease prophylaxis in allogeneic stem cell transplant with human leukocyte antigen-matched donor, grade II-IV acute graft-versus-host disease occurs in 30% to 50% of sibling and up to 80% of unrelated recipients. Studies with limited patient numbers have shown efficacy and safety of mycophenolate mofetil for graft-versus-host disease prophylaxis. We investigated the effect of low-dose mycophenolate mofetil added to a standardized prophylaxis regimen for graft-versus-host disease in related human leukocyte antigen-matched allogeneic stem cell transplant. MATERIALS AND METHODS In this prospective randomized clinical trial, we compared cyclosporine and methotrexate versus the combination of cyclosporine, methotrexate, and mycophenolate mofetil in all patients who underwent human leukocyte antigencompatible related donor allogeneic stem cell transplant for acute leukemia during 3 years at the Bone Marrow Transplant Unit at Namazi Hospital, Shiraz University of Medical Sciences (Shiraz, Iran). RESULTS All 134 patients in both groups underwent successful engraftment. Recovery times for neutrophils and platelets were not significantly different between groups (P < .05). Incidence of acute graft-versus-host disease in the cyclosporine, methotrexate, and mycophenolate mofetil group was less than in the cyclosporine and methotrexate group (21.6% vs 40.9%; P = .041). Incidence of grade II-IV acute graftversus-host disease in the mycophenolate mofetil group was 15.2% versus the control group at 33% (P = .045). CONCLUSIONS Our single-center study suggests the combination of mycophenolate mofetil, cyclosporine, and methotrexate is superior to the standard regimen of cyclosporine and methotrexate for graft-versushost disease prophylaxis after human leukocyte antigen-matched related donor allogeneic stem cell transplant.
Published: 2021
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7. Increased early mortality after fludarabine and melphalan conditioning with peripheral blood grafts in haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide

Author: David A. Russler-Germain, Ramzi Abboud, Thomas J Fountaine, Eric Huselton, Jeffrey R. Andolina, Luke Eastburg, and John F. DiPersio
Subjects: Oncology, Melphalan, Cancer Research, medicine.medical_specialty, Transplantation Conditioning, Cyclophosphamide, Graft vs Host Disease, Internal medicine, Humans, Medicine, Retrospective Studies, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, medicine.disease, Peripheral blood, Fludarabine, Transplantation, Cytokine release syndrome, surgical procedures, operative, medicine.anatomical_structure, Conditioning, Bone marrow, business, Vidarabine, medicine.drug
Abstract: Due to the evolving use of haploidentical donor grafts in hematopoietic cell transplantation, there is increased need to better understand the risks and benefits of using bone marrow versus peripheral blood grafts, as well as how specific pre-transplantation conditioning regimens impact patient safety and treatment outcomes. We performed a retrospective analysis of 38 patients at two centers who underwent haploidentical hematopoietic cell transplantation using fludarabine plus melphalan-based conditioning regimens with post-transplant cyclophosphamide and peripheral blood donor grafts. We observed an unexpectedly high rate of early non-relapse mortality and severe cytokine release syndrome. The poor outcomes with 1-year overall survival of 34%, disease-free survival of 29%, and non-relapse mortality of 34% motivate us to reconsider the appropriateness of the combination of fludarabine and melphalan conditioning with T-cell replete peripheral blood grafts in the setting of haploidentical hematopoietic cell transplant with post-transplant cyclophosphamide.
Published: 2021
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8. Serrated polyps and polyposis of the colon: a brief review for surgeon endoscopists

Author: Jason Park, Harminder Singh, H. Robert Wightman, Ramzi M. Helewa, and Eric Hyun
Subjects: High rate, Serrated adenoma, medicine.medical_specialty, Discussions in Surgery, business.industry, education, Colonic Polyps, Colonoscopy, medicine.disease, Dermatology, Serrated polyposis, digestive system diseases, Hyperplastic Polyp, Dysplasia, Practice Guidelines as Topic, medicine, Humans, Surgery, Molecular Profile, Colorectal Neoplasms, business
Abstract: Summary Serrated polyps (SPs) were once considered benign, clinically unimportant lesions. However, it is now recognized that through the serrated neoplasia pathway (SNP), SPs play a role in the development of 15%–30% of cases of colorectal cancers (CRC). Furthermore, a high proportion of postcolonoscopy CRCs are believed to arise from SNP. Serrated polyps are classified into hyperplastic polyps, sessile serrated lesions, sessile serrated lesions with dysplasia, traditionally serrated adenomas, and unclassified serrated adenoma, each with a distinct morphological and molecular profile. Despite improved understanding, SPs remain a clinical challenge owing to evolving terminology, frequent pathologic misclassification, endoscopic underdetection, and high rates of incomplete removal. Surgeon endoscopists and surgeons who perform colorectal procedures will undoubtedly come across patients with SPs, and this paper summarizes some of the clinical challenges they will encounter. We also discuss the diagnosis and management of patients with serrated polyposis syndrome (SPS).
Published: 2021
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9. Using a mixed method to develop consensus-based aims, contents, intended learning outcomes, teaching, and evaluation methods for a course on epilepsy for postgraduate or continuing education in community health nursing programs

Author: Ramzi Shawahna
Subjects: Education, Continuing, Consensus, education, Delphi method, MEDLINE, Scopus, Nurses, Qualitative property, CINAHL, Education, Epilepsy, Nursing, Nominal group technique, medicine, Humans, Learning, Medical education, LC8-6691, Research, General Medicine, medicine.disease, Community Health Nursing, Special aspects of education, Knowledge, Community health, Medicine, Psychology
Abstract: Background Knowledge deficits with regard to epilepsy have been reported among healthcare professionals. This study was conducted to develop consensus-based aims, contents, intended learning outcomes, teaching, and evaluation methods for a course on epilepsy for postgraduate or continuing education in community health nursing programs. Methods A mixed method which combined a thorough search of literature, the nominal group technique, the Delphi technique, and survey of students’ agreement was used. The databases MEDLINE/PUBMED, EMBASE, COCHRANE, CInAHL/EBESCO, SCOPUS, Google Scholar, Google Books, and Amazon were searched to identify potential aims, topics/contents, intended learning outcomes, teaching, and evaluation methods. Discussions and deliberations in serial meetings based on the nominal group technique were attended by educators/academicians (n = 12), neurologists (n = 2), practicing nurses (n = 5), pharmacists (n = 2), patients with epilepsy (n = 2), and students in postgraduate and continuing education programs (n = 7) to supplement and refine the data collected from the literature. The qualitative data were analyzed using RQDA tool for R. The Delphi technique was used among educators/academicians (n = 15), neurologists (n = 2), practicing nurses (n = 5), pharmacists (n = 2), patients with epilepsy (n = 3), and students in postgraduate and continuing education programs (n = 8) to achieve formal consensus. Results Consensus was achieved on 6 aims, 16 intended learning outcomes, and 27 topics in the course. Of the topics, 13 were relevant to nature of epilepsy and seizures, 2 were relevant to the impact of epilepsy and seizures on different life aspects of patients with epilepsy, 4 were relevant to advocating for the patients and supporting their choices, 5 were relevant to educating patients and their caregivers, and 3 were relevant to assessments and services. Conclusion Consensus-based aims, topics/contents, intended learning outcomes, teaching, and evaluation methods of a course on epilepsy for postgraduate or continuing education in community health nursing programs were developed. Consensus-based courses could bridge knowledge gaps and improve educating community health nursing programs on epilepsy. Further studies are needed to determine if such consensus-based courses could promote care of patients with epilepsy.
Published: 2021

10. Neurobrucellosis

Author: Ramzi Hamouche, Claude Afif, Maroun Bou Zerdan, Youssef Bouferraa, Rosette Jabbour, and Eid Azar
Subjects: medicine.medical_specialty, biology, medicine.diagnostic_test, Lymphocytosis, business.industry, Brucellosis, Magnetic resonance imaging, Brucella, Prognosis, biology.organism_classification, medicine.disease, Magnetic Resonance Imaging, Treatment Outcome, Cerebrospinal fluid, Immune system, Immunology, Epidemiology, Humans, Medicine, medicine.symptom, business, Meningitis
Abstract: BACKGROUND Brucella are small, nonmotile, intracellular, and aerobic gram-negative bacteria. Of the 10 species that currently form the genus Brucella, 5 were shown to be pathogenic in humans. REVIEW SUMMARY The epidemiology, clinical manifestations, diagnosis and imaging, and treatment of neurobrucellosis will be reviewed.Brucellosis's transmission to humans occurs by direct contact with contaminated animals. Older patients are at increased risk of nervous system involvement in brucellosis. Brucella spp. can lead to central nervous system involvement through direct damage via invasion of neural tissue or indirect damage caused by endotoxins or immune inflammatory reactions elicited by the presence of the bacteria in the body. Patients can have general nonspecific symptoms in addition to neurological and psychiatric symptoms. There are 4 diagnostic criteria for the diagnosis of neurobrucellosis, which include signs and symptoms suggestive of neurobrucellosis, a positive finding of Brucella spp. in the cerebrospinal fluid (CSF), and/or a positive titer of antibodies targeting brucella in the CSF, lymphocytosis with high protein levels and low glucose levels in CSF, and imaging findings (either cranial magnetic resonance imaging or computed tomography) peculiar to neurobrucellosis. For the treatment, a combined therapy is favored over monotherapy for the eradication of Brucella. Moreover, a multirouted therapy has been associated with increased treatment efficacy. The prognosis of neurobrucellosis is dependent on patients' clinical presentation: brucellar meningitis is associated with a good prognosis, whereas diffuse central nervous system involvement is associated with the development of long-term sequelae. CONCLUSIONS Neurobrucellosis affects patients globally and in endemic areas. Neurologists should familiarize themselves with its clinical presentation, diagnosis, and treatment to provide optimal care for their patients.
Published: 2021
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11. A comparative study of the identification frequency and composition of bacteria isolated from catheter and urine in urologic patients: A single-center descriptive study

Author: Ashraf Ibrahim Mohammed Hassan, Ramzi Mowffaq Ramzi, and Bashar M Al-Hammodi
Subjects: medicine.medical_specialty, food.ingredient, biology, business.industry, Urology, Urinary system, Biochemistry (medical), Urethral Catheters, Urine, Bacteriuria, biology.organism_classification, medicine.disease, Catheter, food, Nephrology, Immunology and Allergy, Medicine, Agar, business, Bacteria, Antibacterial agent
Abstract: This study aimed to compare the identification frequency and composition of bacteria isolated from catheter and urine in urologic patients. Methods: Ninety patients with urethral catheters were involved in the study. Urinary and catheter cultures were taken simultaneously from each patient and cultured on MacConkey's agar. Urine culture and sensitivity were performed for all samples in pre- and postoperative periods. Swab culture and sensitivity from the surface of intraluminal urethral catheters were performed for all cases in the post-operative period. Results: The median indwelling period of the catheters was 8 days (range 3 to 21). The overall positive rate of catheter culture was significantly greater than that of urine culture, even in subjects without a recent antibacterial agent history. Urine cultures and catheter cultures did not match each other completely. The percentage of patients who had the same bacterial species isolated from both specimens increased in a time-dependent manner. Conclusions: Not all species of bacteria colonizing the intraluminal surface of the urethral catheter were detected as urinary bacteria. Bacterial colonization on the intraluminal catheter surface could precede the emergence of bacteriuria.
Published: 2020
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12. Rates and predictors of repeat preoperative endoscopy for elective colorectal resections: how can we avoid repeated procedures?

Author: Kathleen Clouston, Jason Park, Olivia Hershorn, Ashley Vergis, Ramzi M. Helewa, and Harminder Singh
Subjects: Male, Canada, medicine.medical_specialty, Colorectal cancer, Colonoscopy, Rectum, Logistic regression, Endoscopy, Gastrointestinal, Internal medicine, medicine, Humans, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Retrospective cohort study, Hepatology, medicine.disease, Surgery, Endoscopy, medicine.anatomical_structure, Female, Colorectal Neoplasms, business, Abdominal surgery
Abstract: BACKGROUND Despite limited endoscopy resources, repeat endoscopy prior to surgery is commonly practised. Our aim was to determine repeat preoperative endoscopy rates and factors influencing this practice at a high-volume Canadian tertiary centre. METHOD A retrospective cohort study was conducted on all patients undergoing elective colorectal resections for benign and malignant neoplasms at a tertiary centre in Winnipeg, Canada between 2007 and 2017. Multivariable logistic regression analysis was used to identify predictors of repeat preoperative endoscopy. RESULTS Of 1062 patients identified, mean age was 68 years and 56% were male. Rate of repeat preoperative endoscopy was 29%. On multivariable analysis, male sex (OR 1.68, CI 1.19-2.34, p = 0.003) and lesions located in the left colon (OR 2.73, CI 1.79-4.14, p
Published: 2021
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13. Exploring the Interactions between Non-Medical Methamphetamine Use and Prescribed Buprenorphine or Naltrexone in Opioid Use Disorder Treatment Retention

Author: Tyler Vanderhoof, Mark D Wright, Shannon C. Miller, Ramzi W. Nahhas, Samantha O Vanderhoof, Sydney M. Silverstein, and Danielle M. Gainer
Subjects: Health (social science), Narcotic Antagonists, Medicine (miscellaneous), Treatment retention, (+)-Naloxone, Injections, Intramuscular, Naltrexone, Methamphetamine, medicine, Humans, In patient, Retrospective Studies, business.industry, Public Health, Environmental and Occupational Health, Opioid use disorder, Opioid-Related Disorders, medicine.disease, Buprenorphine, Psychiatry and Mental health, Methamphetamine use, Delayed-Action Preparations, Anesthesia, business, medicine.drug
Abstract: Our objectives were to examine the impact of methamphetamine use on opioid use disorder (OUD) treatment retention in patients prescribed either buprenorphine/buprenorphine-naloxone (BUP-NX) or naltrexone/extended-release naltrexone (XR-NTX), while also exploring the role of other risk factors that may modify the impact of methamphetamine use.We conducted an exploratory retrospective study examining OUD treatment retention in 127 patients in Ohio (USA). Patients were prescribed either BUP-NX or naltrexone/XR-NTX. Cox proportional hazard regression was used to compare time to dropout of treatment between patients positive and negative on screening for methamphetamines at intake, estimate the association between other risk factors and time to dropout, and test interactions between risk factors and methamphetamine status.Among patients prescribed naltrexone/XR-NTX, those positive for methamphetamines had almost three times the risk of treatment dropout (AHR = 2.89, 95% CI =1.11, 7.07), significantly greater (interactionAdditional support should be provided to patients who use methamphetamines prior to starting OUD treatment.
Published: 2021
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14. Impact of Climate Variability and Incidence on Dengue Hemorrhagic Fever in Palembang City, South Sumatra, Indonesia

Author: Ahmad Ghiffari, Ramzi Amin, Chandra Irsan, Chairil Anwar, Irfanuddin Irfanuddin, and Minarti Rubel
Subjects: Aedes, Veterinary medicine, biology, Dengue hemorrhagic fever, business.industry, Task force, Incidence (epidemiology), Mosquito breeding, General Medicine, Dengue virus, biology.organism_classification, medicine.disease, medicine.disease_cause, Dengue fever, medicine, Correlation test, business
Abstract: Dengue hemorrhagic fever (DHF) is a dengue virus infection transmitted by Aedes spp. Climate has a profound influence on mosquito breeding. Palembang has the highest rate of DHF in South Sumatra. This study aimed to investigate the relationship between the components of climate factors and the incidence of DHF in Palembang. This study was cross-sectional, with an observational analytic approach. The Palembang City Health Office compiled data on DHF incidence rates from 2016 to 2020. Climatic factor data (rainfall, number of rainy days, temperature, humidity, wind speed, sun irradiance) were collected from the Climatology Station Class I Palembang - BMKG Station and Task Force that same year. The Spearman test was used to conduct the correlation test. Between 2016 and 2020, there were 3,398 DHF patients. From January to May, DHF increased. There was a significant correlation between rainfall (r = 0.320; p = 0.005), number of rainy days (r = 0.295; p = 0.020), temperature (r = 0.371; p = 0.040), and humidity (r = 0.221; p = 0.024), wind speed (r= 0.76; p = 0.492), and sunlight (r = 0.008; p = 0.865). Rainfall, the number of rainy days, and temperature were three climatic factors determining the increase in dengue incidence in Palembang.
Published: 2021
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15. Stroke Incidence and Outcome in a Population With COVID-19

Author: Moayd M. Alkhalifah, Ramzi Banda, Shukri Alqudihy, Shireen Qureshi, and Jaffar A. Al-Tawfiq
Subjects: medicine.medical_specialty, education.field_of_study, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, medicine.disease, Internal medicine, Epidemiology, medicine, Neurology (clinical), education, Infectious Disease Medicine, business, Stroke incidence, Stroke
Abstract: Background and Purpose: COVID-19 is associated with systemic thromboembolism including stroke. The study evaluated the 30-days stroke incidence in SARS-CoV-2 PCR positive patients and described the outcome of such patients. Methods: This is a retrospective study of consecutive patients with a positive SARS-CoV-2 PCR test between March 1st, 2020 and August 30th, 2020. The study included COVID-19 patients who were hospitalized and had a stroke within 30 days from the positive PCR test. Results: During the study period, there were 4301 patients with a positive SARS-CoV-2 PCR test. Of those, 1786 patients (41.5%) were hospitalized and 4 patients developed a stroke within 30 days. The 30-days stroke incidence was 0.09% and 0.2% of all and hospitalized patients, respectively. The mean age of stroke patients was 78 years and 2 died during the same hospitalization. The 4 patients had comorbidities, one had pre-existing atrial fibrillation and all had ischemic stroke. Conclusion: This study showed a low 30-day incidence of stroke among COVID-19 patients.
Published: 2021
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16. Assessment of Lung Cancer Screening Eligibility on NCI-Designated Cancer Center Websites

Author: Samantha R. Paige, Ramzi G. Salloum, and Lisa Carter-Harris
Subjects: medicine.medical_specialty, Task force, business.industry, Pharmacology toxicology, Public Health, Environmental and Occupational Health, Cancer, medicine.disease, Online assessment, Oncology, Family medicine, medicine, Lung cancer, business, Healthcare providers, Lung cancer screening
Abstract: Online lung cancer screening assessments empower patients to learn about their risk for lung cancer and eligibility for screening. However, it is unknown whether these online assessments provide tailored recommendations that are consistent with national guidelines and include information to prepare patients for shared decision-making (SDM) consultations with their healthcare provider. In November 2019, we reviewed 71 NCI-Designated Cancer Center websites to identify US Preventive Services Task Force (USPSTF) guidelines for lung cancer screening eligibility and evidence-based features of shared decision-making (SDM). Only 11% of the websites included an online lung cancer screening assessment. Most assessments included tailored recommendations for screening eligibility based on USPSTF guidelines. Assessments designed to support SDM included both potential benefits and harms of undergoing lung cancer screening. Nearly all assessments directed adults to discuss the results with their healthcare provider and reinforced the importance of living a tobacco-free lifestyle. Online lung cancer screening assessments have the potential to put patients in control of knowledge about their lung cancer risk and screening eligibility. While nearly all assessments recommend patients to speak with their healthcare provider about their risk for lung cancer, patients may require more support to initiate and navigate SDM conversations with their providers.
Published: 2021
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17. Homeopathic Treatment for COVID-19-Related Symptoms: A Case Series

Author: Amir Jarjoui, Gabriel Izbicki, Philip Levin, Ramzi Kurd, Jeremy Sherr, Menachem Oberbaum, Yakov Freed, and Yigal Helvitz
Subjects: medicine.medical_specialty, Pandemic, business.industry, Pandemie, COVID-19, Homeopathy, Disease, medicine.disease_cause, medicine.disease, Intensive care unit, law.invention, Clinical trial, Coronavirus, Pneumonia, Complementary and alternative medicine, Case Report / Kasuistik, Homöopathie, law, Infectious disease (medical specialty), medicine, Intensive care medicine, business
Abstract: Background: Severe acute respiratory syndrome due to coronavirus 2 (SARS CoV-2) is a novel infectious disease, which has quickly developed into a pandemic. The spectrum of COVID-19 symptoms is broad, ranging from a mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure and possible death. Despite much effort and multiple clinical trials, there are, to date, no specific therapeutic agents to treat or cure the coronavirus infection. Case Reports: The present paper presents 5 cases of patients with moderate to severe COVID-19 infections, 2 of them hospitalized in the intensive care unit, who were successfully treated with homeopathy. Results: All 5 patients responded to homeopathic treatment in an unexpectedly short time span, improving both physically and mentally. Conclusion: The present case series emphasizes the rapidity of response among moderate to severely ill patients to homeopathic treatment, when conventional medical options have been unable to relieve or shorten the disease. The observations described should encourage use of homeopathy in treating patients with COVID-19 during the acute phase of the disease.
Published: 2021

18. A Strangulated Meckel’s Diverticulum in an Inguinal Hernia: A Case Report and Literature Review

Author: David J. Hochman, Garrett G R J Johnson, Ramzi M. Helewa, James Holden, and Eric Hyun
Subjects: Meckel's diverticulum, medicine.medical_specialty, Groin, business.industry, digestive, oral, and skin physiology, Adult population, Embryologic remnant, Case Report, Littré’s hernia, General Medicine, medicine.disease, digestive system, digestive system diseases, Surgery, Inguinal hernia, stomatognathic diseases, medicine.anatomical_structure, surgical procedures, operative, Meckel’s diverticulum, inguinal hernia, Medicine, Hernia, Vitelline duct, business, Diverticulum
Abstract: Background Meckel's diverticulum is an embryologic remnant of the vitelline duct, occurring in approximately 2% of the adult population. A hernia containing a Meckel's diverticulum is called a Littre's hernia and is rarely reported in the medical literature. Clinically, a Littre's hernia is indistinguishable from a hernia containing small bowel and is often discovered incidentally during a repair. Case Presentation Herein, we report a rare case of strangulated Littre's hernia in a patient's right groin. The sac contained a long segment of small bowel in addition to a large Meckel's diverticulum. The bowel was irreducible through the groin incision, and a lower midline laparotomy was made. Necrotic bowel including the Meckel's diverticulum was resected. Given the presence of necrotic bowel and potential for infection, the hernia was repaired with a Bassini herniorrhaphy, reinforced with absorbable mesh. The patient recovered uneventfully. Conclusion Littre's hernia is a rare clinical entity. Treatment is similar to any bowel-containing hernia. Repair of the hernia defect with permanent mesh should be weighed against the risk of implant infection.
Published: 2021

19. Impact of Serum Prolactin and Testosterone Levels on Male Infertility in Sulaimanyah City

Author: Zhian Salah Ramzi and hadeel Abdulelah ibrahim
Subjects: Serum prolactin, medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, medicine, Testosterone (patch), General Medicine, medicine.disease, business, Spermatogenesis, Prolactin, Male infertility
Published: 2021
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20. Perioperative and Postoperative Outcomes of Robot-Assisted Radical Prostatectomy in Prostate Cancer Patients with Prior Transurethral Subvesical Deobstruction: Results of a High-Volume Center

Author: Bernhard Fangmeyer, Nikolaos Liakos, Christian Wagner, Sami-Ramzi Leyh-Bannurah, Andreas Schuette, Mikolaj Mendrek, Joerg Zinke, Matthias Oelke, Jorn H. Witt, and Daniel Wasiri
Subjects: medicine.medical_specialty, Prostatectomy, business.industry, Urology, medicine.medical_treatment, Enucleation, Salvage therapy, Urinary incontinence, Perioperative, medicine.disease, Surgery, Prostate cancer, Erectile dysfunction, medicine.anatomical_structure, Prostate, medicine, medicine.symptom, business
Abstract: Purpose:Prostate cancer patients who are scheduled for robot-assisted radical prostatectomy often have a history of transurethral resection or laser enucleation of the prostate as treatment of beni...
Published: 2021
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21. Severe Vitamin B12 Deficiency Mimicking Microangiopathic Hemolytic Anemia

Author: Ramzi Hassouneh, Olivia Lee, Steve Shen, Patrick Fadden, Rachel A. Hart, and Logan P. Rhea
Subjects: Microangiopathic hemolytic anemia, Hemolytic anemia, Pseudo-thrombotic microangiopathy, medicine.medical_specialty, business.industry, Anemia, Microangiopathy, Thrombotic thrombocytopenic purpura, Case Report, medicine.disease, Intensive care unit, Gastroenterology, law.invention, Vitamin B12 deficiency, law, hemic and lymphatic diseases, Internal medicine, medicine, Vitamin B12, business, pernicious anemia
Abstract: Most individuals with vitamin B12 deficiency present with anemia, fatigue, and neurologic disturbances such as paresthesia and loss of sensory function if chronic. However, in severe states, it may manifest as hemolytic anemia, thrombocytopenia, schistocytosis, elevated lactate dehydrogenase, and low reticulocyte production. This phenomenon is known as pseudo-thrombotic microangiopathy (TMA), and is most commonly due to pernicious anemia. The overlap in clinical presentation with primary TMA creates a challenge in the diagnosis and management of pseudo-TMA. Primary TMA, particularly thrombotic thrombocytopenic purpura, is emergently managed with plasma exchange and may require admission to an intensive care unit due to high risk of mortality. In contrast, pseudo-TMA does not respond to plasma exchange and instead is treated with vitamin B12 supplementation. Patients with this atypical presentation of B12 deficiency may receive unnecessary, costly, and potentially harmful therapy. We present the case of a patient with pseudo-TMA in the setting of pernicious anemia. J Hematol. 2021;10(4):202-205 doi: https://doi.org/10.14740/jh889
Published: 2021
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22. Covid-19 Patient Condition at Early Pandemic in Jakarta

Author: Fairuz Aulya, Moniqa Ratna, Hamonangan Rachmat, Sulistio Maria Edith, Fransiska Fransiska, Putra Andika Chandra, Alatas Mohammad Fahmi, Koncoro Hendra, Sinto Robert, Wiyono Wiwien Heru, Ramzi Ramzi, Irianti C. Krismini Dwi, Pramono Laurentius Aswin, Sumargono Jb Endrotomo, and Bermawi Bettia
Subjects: Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.diagnostic_test, business.industry, Physical examination, Disease, medicine.disease, Asymptomatic, Neutrophilia, Psychiatry and Mental health, Pneumonia, Diabetes mellitus, Pandemic, medicine, medicine.symptom, business
Abstract: Background: COVID-19 is a disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) that has become a pandemic. It became apparent that COVID-19 transmitting from person to person. The clinical manifestations and characteristics of COVID-19 encompassing from asymptomatic infection until severe pneumonia and death. This study aimed to describe and compare the characteristics between COVID-19 suspected patients and confirmed patients at an early pandemic in Jakarta, Indonesia. Methods: A cross-sectional design was used in this study. Data were collected from March to April 2020 using the electronic health record reporting database, initial laboratory tests, and RT-PCR for SARS-CoV-2 results. There were 58 subjects: 43 COVID-19 confirmed patients and 15 COVID-19 suspected patients. Results: Male was found predominantly in COVID-19 confirmed patients than female. The mean age of confirmed patients was 49,6 years old. Nearly half of the confirmed patients had comorbidities namely hypertension and diabetes mellitus. Fever and cough were the most common presenting symptoms, and they were also found in suspected patients. Confirmed patients tended to have lymphopenia and neutrophilia. Pulmonary infiltrate was the most common feature in both confirmed and suspected patients. Conclusion: There were no significant differences found between COVID-19 confirmed and suspected cases regarding demographic characteristics, comorbidities, presenting symptoms, physical examination results, laboratory tests, and chest x-ray results. COVID-19 confirmed patients had a history of exposure to COVID-19 confirmed patients.
Published: 2021
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23. The Correlation of No Footwear Use and Soil Helminth Incidence among Elementary School Children in Musi Rawas, South Sumatera, Indonesia

Author: Silvia Rahmi, Ahmad Ghiffari, Ramzi Amin, Hamzah Hasyim, and Chairil Anwar
Subjects: biology, business.industry, Incidence (epidemiology), worm infections, Helminthiasis, kid pupils, RM1-950, biology.organism_classification, Logistic regression, medicine.disease, Nonprobability sampling, Personal hygiene, not wearing shoes, Environmental health, stool examination, parasitic diseases, Medicine, Trichuris trichiura, Helminths, Therapeutics. Pharmacology, Neurology. Diseases of the nervous system, tuah negeri district, Ascaris lumbricoides, RC346-429, business
Abstract: Background: Soil-transmitted helminth infection (STH) is a parasite infection that involves humans being infected with roundworms by route of soil contamination. One billion individuals are infected with worms, including 568 million school-age children. Helminthiasis in elementary school-aged children was not documented in Musi Rawas Regency. This study's goal was to identify if not wearing footwear increases the incidence of parasitic infection.Methods: The research was a cross-sectional survey, followed by statistical analysis. The study involved elementary school-aged students in Tuah Negeri District, Musi Rawas Regency, in 2021 and at least 200 participants. This study sample consisted of 108 with a purposive sampling method. This study utilized questionnaires and stool examinations using the Kato Katz method. Chi-square and multivariate logistic regression were used for statistical analysis.Results: Positive helminth infections amounted to 37,1% of the total (n=108). STH was comprised of 17.6% Ascaris lumbricoides, 9.3% Trichuris trichiura, and 25.9% hookworms. The finding of this research demonstrated a substantial (p = 0.000) relationship between the use of footwear and the advent of parasites. The logistic regression analysis results revealed that the most critical variable influencing the incidence of helminthiasis was not wearing any footwear.Conclusions: The study's findings suggest a correlation between footwear use and the risk of worm infection; as a result, it was recommended that children be thoroughly educated on personal hygiene, specifically footwear use, when using the bathroom.
Published: 2021
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24. Dental Anxiety and Fear among Patients in Jazan, Kingdom of Saudi Arabia: A Cross-sectional Study

Author: Lujain I. Aldosari, Manea M Al-Ahmari, Hafiz A Adawi, Thiyezen Abdullah Aldhelai, Nasser M Al Ahmari, Ramzi F Alqatta, Mannaa K Aldowsari, and Mohammed M Al Moaleem
Subjects: medicine.medical_specialty, biology, business.industry, Cross-sectional study, Dental fear, biology.organism_classification, medicine.disease, Logistic regression, Khat, Male patient, Family medicine, Medicine, Anxiety, Marital status, Clinical significance, medicine.symptom, business, General Dentistry
Abstract: AIM The current study aims to address the patient's dental anxiety (DA) And dental fear (DF) under the treatment of a general practitioner (GP) among different parameters. MATERIALS AND METHODS The cross-sectional study included 500 patients recruited from different clinics in Jazan, Saudi Arabia. Data were collected through a questionnaire-based form consisting of three parts; the first part was personal and demographic questions whereas the second and third parts were a modified dental anxiety scale (MDAS) and a dental fear survey (DFS) to measure DA and DF among patients. Spearman's correlation was used to measure the relation between DA and DF as well as Chi-square tests and logistic regression analyses for analyzing the effect of each variable on DA and DF. RESULTS All patients fulfilled their eligibility criteria. A high percentage was found in moderate anxiety (36.8%) as well as in moderate fear (46.2%) among different anxiety and fear scales. The association between DA and DF was positively significant (p
Published: 2021
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25. Relationship of Food Leftover with Covid-19 Inpatients Recovery Speed in Palembang Indonesia

Author: Chairil Anwar, Yuanita Windusari, Ramzi Amin, Devi Eryanti, and Ahmad Ghiffari
Subjects: Referral, Coronavirus disease 2019 (COVID-19), Hospitalized patients, business.industry, digestive, oral, and skin physiology, RM1-950, High food, medicine.disease, Nonprobability sampling, Food waste, Malnutrition, recovery, covid-19, food waste, Environmental health, Medicine, Food service, Therapeutics. Pharmacology, Neurology. Diseases of the nervous system, business, RC346-429, feeding, hospitalization
Abstract: Background : Hospital nutrition services support the patient's recovery process, which the activity is feeding. One indicator of quality in food service is food leftover. The high food waste can affect the patient's health. The high food waste will pose a risk of malnutrition in hospitalized patients. The study aimed to analyze the food leftovers in COVID-19 inpatients at the Palembang referral hospital.Methods : This cross-sectional quantitative descriptive study was with a sample of 112 patients selected by purposive sampling in February-May 2021. Data were taken using the Comstock form and then translated in the form of percent leftover food. According to the Minister of Health, the minimum leftover food is less than 25 percent.Results : The results showed that more than 25 percent of the leftover food were 51 respondents; Thirty-three respondents (54.1%) have fully recovered and 28 respondents (45.9%) still in improvement. On the other hand, the leftovers food of less than 25 percent were 51 respondents; Forty respondents (78.4%) have fully cured, and 11 people (21.6%) still in treatments. The analysis of Chi-square test results shows a p-value of 0.013, showing a significant relationship between food waste and the recovery of COVID-19 patients.Conclusion : The food waste of COVID-19 patients in referral hospitals was still relatively high. It is necessary to modify the diet menu to prevent leftovers and speed up the patient's recovery.
Published: 2021

26. Efficient Synergistic Combination Effect of Endurance Exercise with Curcumin on Breast Cancer Progression Through Inflammatory Pathway Inhibition in BALB/C Mice

Author: Fatemeh Ramzi and Maryam Delfan
Subjects: Medicine (General), biology, business.industry, nf-k, Pharmacology, Synergistic combination, biology.organism_classification, medicine.disease, BALB/c, chemistry.chemical_compound, Breast cancer, breast cancer, R5-920, chemistry, endurance training, Endurance training, Curcumin, Medicine, curcumin, business, tnf- α
Abstract: Introduction: TNF-α/NF-kB signaling pathway plays an important role in promoting the inflammatory process and growth of breast cancer. Accordingly, the aim of the present study was to investigate the synergistic combination effect of endurance exercise with curcumin on breast cancer progression through TNF-α/NF-kB signaling axes in female BALB/c mice with breast cancer. Methods: The design of the present study was experimental. After transplanting 4T1 breast cancer into the right flank of 40 BALB/c mice, all mice were randomly divided into four groups, including endurance training (E), endurance training-curcumin (EC), curcumin (CC), and control (C). Then, E and EC groups (5 days per week) were performed for 5 weeks. Curcumin (6 times per week) was given by gavage to EC and CC groups for five weeks. The intratumoral expression of TNF-α and NF-kβ were measured using the qRT-PCR method. One-way analysis of variance and LSD post hoc test with SPSS version 16 were used for statistical analysis. P< 0.05 was considered statistically significant. Results: A significant decline in cancer growth and the gene expression of NF-kβ and TNF-α was observed in E, CC, and EC compared to the C group (P =0.001). Furthermore, a significant decline in expression of both genes was observed in EC compared with E. Conclusion: Endurance training combined with curcumin supplementation has a more effective role in reducing TNF-α and NF-κβ, and slowing the growth of breast cancer cells when compared with either of other interventions alone.
Published: 2021

27. Implementing a non-local means method to CTA data of aortic dissection

Author: Maya Fitria, Cosmin Adrian Morariu, Ramzi Adriman, and Josef Pauli
Subjects: Aortic dissection, noise reduction, business.industry, Computer science, Noise reduction, non-local means, ct image, denoising method, Pattern recognition, QA75.5-76.95, medicine.disease, Non-local means, Visualization, Electronic computers. Computer science, medicine, Preprocessor, Segmentation, Artificial intelligence, Noise (video), Medical diagnosis, aortic dissection, business
Abstract: It is necessary to conserve important information, like edges, details, and textures, in CT aortic dissection images, as this helps the radiologist examine and diagnose the disease. Hence, a less noisy image is required to support medical experts in performing better diagnoses. In this work, the non-local means (NLM) method is conducted to minimize the noise in CT images of aortic dissection patients as a preprocessing step to produce accurate aortic segmentation results. The method is implemented in an existing segmentation system using six different kernel functions, and the evaluation is done by assessing DSC, precision, and recall of segmentation results. Furthermore, the visual quality of denoised images is also taken into account to be determined. Besides, a comparative analysis between NLM and other denoising methods is done in this experiment. The results showed that NLM yields encouraging segmentation results, even though the visualization of denoised images is unacceptable. Applying the NLM algorithm with the flat function provides the highest DSC, precision, and recall values of 0.937101, 0.954835, and 0.920517 consecutively.
Published: 2021

28. Clinical characteristics and outcomes of patients with pediatric acute lymphoblastic leukemia after induction of chemotherapy: a pilot descriptive correlational study from Palestine

Author: Ramzi Shawahna, Sultan Mosleh, Majd Al-Ghoul, Yahya Odeh, and Rami Halawa
Subjects: 0301 basic medicine, medicine.medical_specialty, Palestine, Science (General), Neutrophils, QH301-705.5, medicine.medical_treatment, Translocation, Chromosomal translocation, Acute lymphoblastic leukemia, General Biochemistry, Genetics and Molecular Biology, Translocation, Genetic, 03 medical and health sciences, Leukocyte Count, Q1-390, 0302 clinical medicine, Pediatric Acute Lymphoblastic Leukemia, Internal medicine, Medicine, Humans, Biology (General), Child, Chemotherapy, business.industry, Remission Induction, Cytogenetics, Cancer, Induction chemotherapy, General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Treatment, Research Note, 030104 developmental biology, 030220 oncology & carcinogenesis, Hyperdiploidy, business
Abstract: Objective Pediatric acute lymphoblastic leukemia (ALL) is the most prevalent type of cancer among children. This study was conducted to describe and correlate the clinical characteristics and outcomes of treatment of patients with pediatric ALL in the main referral hospital in Palestine. Results Complete data of 69 patients were included in this analysis. The majority (79.7%) of the patients had B-ALL phenotype. After induction chemotherapy, remission was experienced by the vast majority of the patients and 5 (7.2%) experienced relapses. Cytogenetics for patients with B-ALL phenotype indicated that 10 (18.2%) patients had t(12, 21) translocation, 5 (9.1%) had hyperdiploidy, 4 (7.3%) had t(1, 19) translocation, and 2 (3.6%) had t(9, 22) translocation. The initial white blood cells (p value
Published: 2021

29. Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic

Author: Glasbey, James C, Omar, Omar, Nepogodiev, Dmitri, Minaya-Bravo, Ana, Bankhead-Kendall, Brittany Kay, Fiore, Marco, Futaba, Kaori, Gabre-Kidan, Alodia, Gujjuri, Rohan R, Isik, Arda, Kaafarani, Haytham MA, Kamarajah, Sivesh K, Li, Elizabeth, Loeffler, Markus W, McLean, Kenneth A, Outani, Oumaima, Ntirenganya, Faustin, Satoi, Sohei, Shaw, Richard, Simoes, Joana FF, Stewart, Grant D, Tabiri, Stephen, Trout, Isobel M, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Venn, Mary L, Wilkin, Richard JW, Bhangu, Aneel, Smart, Neil J, Gallo, Gaetano, Moug, Susan, Pata, Francesco, Pockney, Peter, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Griffiths, Ewen A, Evans, Richard PT, Townend, Philip, Roberts, Keith, McKay, Siobhan, Isaac, John, Edwards, John, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Hutchinson, Peter, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Biel, Juan Rey, Batstone, Martin, Ganly, Ian, Vidya, Raghavan, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Sundar, Sudha, Fotopoulou, Christina, Leung, Elaine, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Rajkumar, Shylasree TS, Ng, Joe, Fujiwara, Keiiji, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, Jose, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Ghosh, Dhruv, Gomes, Gustavo Mendonca Ataide, Grecinos, Gustavo, Grundl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jonker, Pascal, Keller, Debby, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Loffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Roslani, April C, Rutegard, Martin, Segura-Sampedro, Juan Jose, Santos, Irene, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Allemand, C, Boccalatte, L, Figari, M, Lamm, M, Larranaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Alurralde, C, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, Garcia, JS, Garcia, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Lam, YH, Ong, BS, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Wright, G, Lanner, M, Koenigsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Oefner, D, Tsibulak, I, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Oehlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St John, S, Walkes, K, Flamey, N, Pattyn, P, Oosterlinck, W, Van den Eynde, J, Van den Eynde, R, Gatti, A, Nardi, C, Oliva, R, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, Terra, RM, Sokolov, M, Kidane, B, Srinathan, S, Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Dumitra, S, Kouyoumdjian, A, Johnston, B, Russell, C, Demyttenaere, S, Garfinkle, R, Abou-Khalil, J, Nessim, C, Stevenson, J, Heredia, F, Almeciga, A, Fletcher, A, Merchan, A, Puentes, LO, Mendoza Quevedo, J, Bacic, G, Karlovic, D, Krsul, D, Zelic, M, Luksic, I, Mamic, M, Bakmaz, B, Coza, I, Dijan, E, Katusic, Z, Mihanovic, J, Rakvin, I, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Szubota, I, Zatecky, J, Javurkova, V, Klat, J, Avlund, T, Christensen, P, Harbjerg, JL, Iversen, LH, Kjaer, DW, Kristensen, HO, Mekhael, M, Ebbehoj, AL, Krarup, P, Schlesinger, N, Smith, H, Abdelsamed, A, Azzam, AY, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, Abosamak, NE, 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H., Abdelkarem, M. M., Alaa, S., Ali, A. K., Ayman, A., Azizeldine, M. G., Elkhayat, H., Melghazaly, S., Monib, F. A., Nageh, M. A., Saad, M. M., Salah, M., Shahine, M., Yousof, E. A., Youssef, A., Eldaly, A., Elfiky, M., Nabil, A., Amira, G., Sallam, I., Sherief, M., Sherif, A., Abdelrahman, A., Aboulkassem, H., Ghaly, G., Hamdy, R., Morsi, A., Sherif, G., Abdeldayem, H., Abdelkader, S. I., Balabel, M., Fayed, Y., Sherif, A. E., Bekele, D., Kauppila, J., Sarjanoja, E., Helminen, O., Huhta, H., Kauppila, J. H., Beyrne, C., Jouffret, L., Lugans, L., Marie-Macron, L., Chouillard, E., De, S. B., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Testelin, S., Boucher, S., Breheret, R., Gueutier, A., Kahn, A., Kun-Darbois, J., Barrabe, A., Lakkis, Z., Louvrier, A., Manfredelli, S., Mathieu, P., Chebaro, A., Drubay, V., El, A. M., Eveno, C., Lecolle, K., Legault, G., Martin, L., Piessen, G., Pruvot, F. 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J., Gillen, K., Hasenburg, A., Krajnak, S., Linz, V., Schwab, R., Angelou, K., Haidopoulos, D., Rodolakis, A., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Fragulidis, G., Gklavas, A., Konstadoulakis, M., Memos, N., Papaconstantinou, I., Polydorou, A., Theodosopoulos, T., Vezakis, A., Antonopoulou, M. I., Manatakis, D. K., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Tsaousis, V., Vassiliu, P., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Baxevanidou, K., Bouliaris, K., Chatzikomnitsa, P., Efthimiou, M., Giaglaras, A., Kalfountzos, C., Koukoulis, G., Ntziovara, A. 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T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone, F. N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De, P. G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni', A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Capizzi, V., Cioffi, S. P. B., Citterio, D., Comini, L. 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T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De, N. P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De, C. E., De, I. P., Dondi, G., Frio, F., Jovine, E., Mineo, B. F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di, M. G. 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I., Salamah, A., Salem, M., Shuwayyah, A., Abdulwahed, E., Alshareea, E., Aribi, N., Aribi, S., Biala, M., Ghamgh, R., Morgom, M., Aldayri, Z., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevicius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Ong, E. C., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin, S. N., Hayati, F., Jayasilan, J., Sriram, R. K., Subramaniam, S., Che, J. A., Hussain, A. H., Mohamed, S. A. S., Mohdyunus, M. F., Soh, J. Y., Wong, M. P. K., Zakaria, A. D., Zakaria, Z., Fadzli, A., Fathi, N. Q., Koh, P. S., Liew, Y. T., Tang, C. Y., Teoh, L. Y., Wong, W. J., Yahaya, A. S., Alvarez, M. R., Arrangoiz, R., Cordera, F., De, L. R. A. M., Gomez-Pedraza, A., Hernandez, R., Maffuz-Aziz, A., Posada, J. A., Becerra, G. F. C., Alfaro-Goldaracena, A., Buerba, G. A., Castillejos-Molina, R. A., Chan, C., Dominguez-Rosado, I., Medina-Franco, H., Mercado, M. 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Saifeldin H., Saleh M.M.E.M., Samih A., Samir A.A., Shehata S., Shenit K., Attia D., Kamal N., Osman N., Abbas A.M., Abd E.H., Abdelkarem M.M., Alaa S., Ali A.K., Ayman A., Azizeldine M.G., Elkhayat H., Melghazaly S., Monib F.A., Nageh M.A., Saad M.M., Salah M., Shahine M., Yousof E.A., Youssef A., Eldaly A., Elfiky M., Nabil A., Amira G., Sallam I., Sherief M., Sherif A., Abdelrahman A., Aboulkassem H., Ghaly G., Hamdy R., Morsi A., Sherif G., Abdeldayem H., Abdelkader S.I., Balabel M., Fayed Y., Sherif A.E., Bekele D., Kauppila J., Sarjanoja E., Helminen O., Huhta H., Kauppila J.H., Beyrne C., Jouffret L., Lugans L., Marie-Macron L., Chouillard E., De S.B., Bettoni J., Dakpe S., Devauchelle B., Lavagen N., Testelin S., Boucher S., Breheret R., Gueutier A., Kahn A., Kun-Darbois J., Barrabe A., Lakkis Z., Louvrier A., Manfredelli S., Mathieu P., Chebaro A., Drubay V., El A.M., Eveno C., Lecolle K., Legault G., Martin L., Piessen G., Pruvot F.R., Truant S., Zerbib P., Ballouhey Q., 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S., Kleeff J., Lorenz K., Michalski C., Ronellenfitsch U., Schneider R., Bertolani E., Konigsrainer A., Quante M., Steidle C., Uberruck L., Yurttas C., Betz C.S., Bewarder J., Bottcher A., Burg S., Busch C., Gosau M., Heuer A., Izbicki J., Klatte T.O., Koenig D., Moeckelmann N., Nitschke C., Priemel M., Smeets R., Speth U., Thole S., Uzunoglu F.G., Vollkommer T., Zeller N., Battista M.J., Gillen K., Hasenburg A., Krajnak S., Linz V., Schwab R., Angelou K., Haidopoulos D., Rodolakis A., Antonakis P., Bramis K., Chardalias L., Contis I., Dafnios N., Dellaportas D., Fragulidis G., Gklavas A., Konstadoulakis M., Memos N., Papaconstantinou I., Polydorou A., Theodosopoulos T., Vezakis A., Antonopoulou M.I., Manatakis D.K., Tasis N., Arkadopoulos N., Danias N., Economopoulou P., Kokoropoulos P., Larentzakis A., Michalopoulos N., Selmani J., Sidiropoulos T., Tsaousis V., Vassiliu P., Bouchagier K., Klimopoulos S., Paspaliari D., Stylianidis G., Baxevanidou K., Bouliaris K., Chatzikomnitsa P., 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Pickett L., Akmenkalne L., Byrne J., Corrigan M., Cullinane C., Daly A., Fleming C., Jordan P., Killeen S., Lynch N., McCarthy A., Mustafa H., O'Brien S., O'Leary P., Syed W.A.S., Vernon L., Callanan D., Huang L., Ionescu A., Sheahan P., Balasubramanian I., Boland M., Conlon K., Evoy D., Fearon N., Gallagher T., Geraghty J., Heneghan H., Kennedy N., Maguire D., McCartan D., McDermott E.W., Prichard R.S., Winter D., Alazawi D., Barry C., Boyle T., Butt W., Connolly E.M., Donlon N., Donohue C., Fahey B.A., Farrell R., Fitzgerald C., Kinsella J., Larkin J.O., Lennon P., Maguire P.J., McCormick P., Mehigan B.J., Mohan H., Nugent T., O'Sullivan H., Ravi N., Reynolds J.V., Rogers A., Shokuhi P., Smith J., Smith L.A., Timon C., Bashir Y., Bass G., Connelly T., Creavin B., Earley H., Elliott J.A., Gillis A., Kavanagh D., Neary P., O'Riordan J., Reynolds I.S., Rice D., Ridgway P., Umair M., Whelan M., Carroll P., Collins C., Corless K., Finnegan L., Fowler A., Hogan A., Kerin M., Lowery A., McAnena P., McKevitt K., Nizami K., Ryan E., Samy A., Coffey J.C., Cunningham R., Devine M., Nally D., Peirce C., Tormey S., Hardy N., O'Malley S., Ryan M., MacIna S., Mariani N.M., Opocher E., Pisani C.A., Ferrari F., Odicino F., Sartori E., Cotsoglou C., Granieri S., Bianco F., Camillo' A., Colledan M., Tornese S., Zambelli M.F., Bissolotti G., Fusetti S., Lemma F., Marino M.V., Mirabella A., Vaccarella G., Agostini C., Alemanno G., Bartolini I., Bergamini C., Bruscino A., Checcucci C., De V.R., Di B.A., Fambrini M., Fortuna L., Maltinti G., Muiesan P., Petraglia F., Prosperi P., Ringressi M.N., Risaliti M., Sorbi F., Taddei A., Tucci R., Bassi C., Bortolasi L., Campagnaro T., Casetti L., De P.M., Esposito A., Fontana M., Guglielmi A., Landoni L., Malleo G., Marchegiani G., Nobile S., Paiella S., Pedrazzani C., Rattizzato S., Ruzzenente A., Salvia R., Turri G., Tuveri M., Bellora P., D'Aloisio G., Ferrari M., Francone E., Gentilli S., Nikaj H., Bianchini M., Chiarugi M., Coccolini F., Di F.G., Furbetta N., Gianardi D., Guadagni S., Morelli L., Palmeri M., Tartaglia D., Anania G., Carcoforo P., Chiozza M., De T.A., Koleva R.M., Portinari M., Sibilla M.G., Urbani A., Fabbri N., Feo C.V., Gennari S., Parini S., Righini E., Ampollini L., Bellanti L., Bergonzani M., Bertoli G., Bocchialini G., D'Angelo G., Lanfranco D., Musini L., Poli T., Santoro G.P., Varazzani A., Aguzzoli L., Borgonovo G., Castro R.C., Coiro S., Falco G., Mandato V.D., Mastrofilippo V., Montella M.T., Annessi V., Zizzo M., Grossi U., Novello S., Romano M., Rossi S., Zanus G., Esposito G., Frongia F., Pisanu A., Podda M., Belluco C., Lauretta A., Montori G., Moras L., Olivieri M., Bussu F., Carta A.G., Cossu M.L., Cottu P., Fancellu A., Feo C.F., Ginesu G.C., Giuliani G., Madonia M., Perra T., Piras A., Porcu A., Rizzo D., Scanu A.M., Tedde A., Tedde M., Delrio P., Rega D., Badalamenti G., Campisi G., Cordova A., Franza M., Maniaci G., Rinaldi G., Toia F., Calabro M., Farnesi F., Lunghi E.G., Muratore A., Pipitone F.N.S., Bambina F., D'Andrea G., Familiari P., Picotti V., De P.G., Luglio G., Pagano G., Tropeano F.P., Baldari L., Beltramini G.A., Boni L., Cassinotti E., Gianni' A., Pignataro L., Torretta S., Abatini C., Baia M., Biasoni D., Bogani G., Cadenelli P., Capizzi V., Cioffi S.P.B., Citterio D., Comini L.V., Cosimelli M., Folli S., Gennaro M., Giannini L., Zweroncy A., Guaglio M., MacChi A., Martinelli F., Mazzaferro V., Mosca A., Pasquali S., Piazza C., Raspagliesi F., Rolli L., Salvioni R., Sarpietro G., Sarre C., Sorrentino L., Agnes A., Alfieri S., Belia F., Biondi A., Cozza V., D'Amore A., D'Ugo D., De S.V., Gasparini G., Gordini L., Litta F., Lombardi C.P., Lorenzon L., Marra A.A., Marzi F., Moro A., Parello A., Perrone E., Ratto C., Rosa F., Saponaro G., Scambia G., Scrima O., Sganga G., Tudisco R., Belli A., Granata V., Izzo F., Palaia R., Patrone R., Carrano F.M., Carvello M.M., De V.A., Di C.F., Ferreli F., Gaino F., Mercante G., Rossi V., Spriano G., Donati D.M., Frisoni T., Palmerini E., Aprile A., Barra F., Batistotti P., Ferrero S., Fregatti P., Scabini S., Sparavigna M., Asti E., Bernardi D., Bonavina L., Lovece A., Adamoli L., Ansarin M., Cenciarelli S., Chu F., De B.R., Fumagalliromario U., Mastrilli F., Pietrobon G., Tagliabue M., Badellino E., Ferrero A., Massobrio R., De M.G.A., Federico P., Maida P., Marra E., Marte G., Petrillo A., Tammaro T., Tufo A., Berselli M., Borroni G., Cocozza E., Conti L., Desio M., Livraghi L., Quintodei V., Rizzi A., Zullo A., Baldi C., Corbellini C., Sampietro G.M., Cellerino P., Baldini E., Capelli P., Isolani S.M., Ribolla M., Bondurri A., Colombo F., Ferrario L., Guerci C., Maffioli A., Armao T., Ballabio M., Bisagni P., Gagliano A., Longhi M., Madonini M., Pizzini P., Baietti A.M., Biasini M., Maremonti P., Neri F., Prucher G.M., Ricci S., Ruggiero F., Zarabini A.G., Barmasse R., Mochet S., Usai A., Incollingo P., Mancini S., Marino C.L., Sagnotta A., Fruscio R., Grassi T., Nespoli L.C., Tamini N., Anastasi A., Bartalucci B., Bellacci A., Canonico G., Capezzuoli L., Di M.C., Ipponi P., Linari C., Montelatici M., Nelli T., Spagni G., Tirloni L., Vitali A., Abate E., Casati M., Casiraghi T., Laface L., Schiavo M., Arminio A., Cotoia A., Lizzi V., Vovola F., Vergari R., D'Ugo S., Depalma N., Spampinato M.G., Bartolucci P., Brachini G., Bruzzaniti P., Chiappini A., Chiarella V., Ciccarone F., Cicerchia P.M., Cirillo B., De T.G., Fiori E., Fonsi G.B., Franco G., Frati A., Giugliano M., Iannone I., La T.F., Lapolla P., Leonardo C., Marruzzo G., Meneghini S., Mingoli A., Ribuffo D., Salvati M., Santoro A., Sapienza P., Scafa A.K., Simonelli L., Zambon M., Capolupo G.T., Carannante F., Caricato M., Masciana G., Mazzotta E., Gattolin A., Migliore M., Rimonda R., Sasia D., Travaglio E., Cervellera M., Gori A., Sartarelli L., Tonini V., Giacometti M., Zonta S., Chessa A., Fiorini A., Norcini C., Colletti G., Confalonieri M., Costanzi A., Frattaruolo C., Mari G., Monteleone M., Bandiera A., Bocciolone L., Bonavina G., Candiani M., Candotti G., De N.P., Gagliardi F., Medone M., Mortini P., Negri G., Parise P., Piloni M., Sileri P., Vignali A., Belvedere A., Bernante P., Bertoglio P., Boussedra S., Brunocilla E., Cipriani R., Cisternino G., De C.E., De I.P., Dondi G., Frio F., Jovine E., Mineo B.F., Neri J., Parlanti D., Perrone A.M., Pezzuto A.P., Pignatti M., Pinto V., Poggioli G., Ravaioli M., Rottoli M., Schiavina R., Serenari M., Serra M., Solli P., Taffurelli M., Tanzanu M., Tesei M., Violante T., Zanotti S., Borghi F., Cianflocca D., Di M.G.S., Donati D., Gelarda E., Geretto P., Giraudo G., Giuffrida M.C., Marano A., Palagi S., Pellegrino L., Peluso C., Testa V., Agresta F., Prando D., Zese M., Aquila F., Gambacciani C., Pieri F., Santonocito O.S., Armatura G., Bertelli G., Frena A., Marinello P., Notte F., Patauner S., Scotton G., Fulginiti S.F., Sammarco G., Vescio G., Balercia P., Catarzi L., Consorti G., Di M.F., Fontana T., Daiko H., Ishikawa M., Ishiyama K., Iwata S., Kanematsu K., Kanemitsu Y., Kato T., Kawai A., Kobayashi E., Kobayashi K.M., Moritani K., Nakatani F., Oguma J., Tanase Y., Uno M., Al A.M., Ayasra Y., Qasem A., Abu Z.F.J., Fahmawee T., Hmedat A., Ibrahim A., Obeidat K., Abdel A.S., Abdel J.R., Abouchaar M.K., Al-Masri M., Al-Najjar H., Alawneh F., Alsaraireh O., Elayyan M., Ghanem R., Lataifeh I., Alkadeeki G.Z., Al M.F.S., Aldokali N., Senossi O., Subhi M.T., Burgan D., Kamoka E., Kilani A.I., Salamah A., Salem M., Shuwayyah A., Abdulwahed E., Alshareea E., Aribi N., Aribi S., Biala M., Ghamgh R., Morgom M., Aldayri Z., Ellojli I., Kredan A., Bradulskis S., Dainius E., Kubiliute E., Kutkevicius J., Parseliunas A., Subocius A., Venskutonis D., Rasoaherinomenjanahary F., Razafindrahita J.B., Samison L.H., Ong E.C., Hamdan K.H., Ibrahim M.R., Tan J.A., Thanapal M.R., Amin S.N., Hayati F., Jayasilan J., Sriram R.K., Subramaniam S., Che J.A., Hussain A.H., Mohamed S.A.S., Mohdyunus M.F., Soh J.Y., Wong M.P.K., Zakaria A.D., Zakaria Z., Fadzli A., Fathi N.Q., Koh P.S., Liew Y.T., Tang C.Y., Teoh L.Y., Wong W.J., Yahaya A.S., Alvarez M.R., Arrangoiz R., Cordera F., De L.R.A.M., Gomez-Pedraza A., Hernandez R., Maffuz-Aziz A., Posada J.A., Becerra G.F.C., Alfaro-Goldaracena A., Buerba G.A., Castillejos-Molina R.A., Chan C., Dominguez-Rosado I., Medina-Franco H., Mercado M.A., Oropeza-Aguilar M., Pena G.P.E., Posadas-Trujillo O.E., Rodriguez-Covarrubias F., Salgado-Nesme N., Vilatoba M., Arkha Y., Bechri H., El O.A., Oudrhiri M.Y., Derkaouihassani F., El A.N., Amrani L., Belkhadir Z.H., Benkabbou A., Chakib O., El A.B., El B.Y., Essangri H., Ghannam A., Majbar A.M., Mohsine R., Souadka A., Hompes R., Meima-Van P.E.M., Pronk A.J.M., Sharabiany S., Grotenhuis B., Hartveld L., Reijers S., Van H.W., Baaij J., Bolster-Van E.M., De G.M., Sloothaak D., Van D.P., Posma-Bouman L., Derksen T., Franken J., Oosterling S., Konsten J., Van H.M., Fidelis L., Sholadoye T.T., Tolani M.A., Olaogun J., Egbuchulem I.K., Lawal T.A., Ogundoyin O., Olulana D.I., Abdur-Rahman L., Adeyeye A., Aremu I., Bello J., Olasehinde O., Popoola A., Massoud J., Massoud R., Sorour T.M., Jamal A., Kerawala A.A., Memon A.S., Nafees A.R., Rai L., Ayub B., Hassan N., Martins R.S., Ramesh P., Butt U., Kashif M., Khan W.H., Umar M., Warisfarooka M., Wasim T., Ayubi A., Rashid I., Waqar S.H., Falcon G.M., Robles R., Jocson R., Teh C., Bobinski M., Kotarski J., Rasoul-Pelinska K., Azevedo C., MacHado D., Mendes F., De S.X., Fernandes U., Ferreira C., Guidi G., Leal C., Marcal A., Marques R., Martins D., Melo A., Tenreiro N., Vaz P.R., Vieira B., Almeida J.I., Correia D.S.T., Costa M.J.M.A., Fernandes V., Ferraz I., Gil C.G., Lima D.S.C., Lopes L., MacHado N., Marialva J., Nunes C.M., Pedro J., Pereira C., Reis R., Ribeiro A., Santos R., Saraiva P., Silva R., Tavares F., Teixeira M., Almeida A.C., Amaral M.J., Andrade R., Athaydenemesio R., Breda D., Camacho C., Canhoto C., Colino M., Correia S., Costa M., De B.J., De O.L.A., Duque M., Garrido S., Guerreiro P., Guimaraes A., Lazaro A., Lopes C., Martins R., Nogueira O., Oliveira A., Oliveira J.M., Rodrigues M., Ruivo A., Santos E., Silva M., Simoes J., Valente D.C.A., Almeida A., Cavaleiro S., Devezas V., Faria C.S., Jacome F., Magalhaes M.M., Nogueiro J., Pereira A., Pereira-Neves A., Pina-Vaz T., Santos-Sousa H., Silveira H., Vaz S., Vieira P., Gomes D.C.A., Lobo A.I., Pinto J., Tojal A., Cardoso N., Cardoso P., Domingues J.C., Henriques P., Manso M.I., Martins D.S.G., Morais H., Pereira R., Revez T., Ribeiro R., Ribeiro V.I., Soares A., Sousa S., Teixeira J., Amorim E., Baptista V.H., Dias B., Fazenda A., Melo N.J.P., Policarpo F., Sampaio D.N.G.M.I., Veiga D., Andrade A.K., Bandovas J.P., Borges N., Branquinho A., Chumbinho B., Correia J., Fidalgo H., Figueiredo D.B.I., Frade S., Gomes J., MacIel J., Pina S., Rodrigues A., Silva N., Silveira N.I., Sousa R., Ascensao J., Azevedo P., Costeira B., Cunha C., Garrido R., Gomes H., Lourenco I., Mendinhos G., Miranda P., Nobre P.A., Peralta F.M., Ribeiro J., Rio R.L., Sousa F.M., Galvao D., Soares A.C., Vieira A., Patricio B., Santos P.M.D.D., Vieira P.L.A.C., Cunha R., Faustino A., Freitas A., Martins A.B., Mendes J.R., Parreira R., Rosa J., Teves M., Abreu D.S.A., Claro M., Costa S.D., Deus A.C., Grilo J.V., Borges F., Corte R.J., Henriques S., Lima M.J., Matos C.P., Brito D.S.F., Caiado A., Fonseca F., Angelo M., Baiao J.M., Martins J.D., Vieira C.T., Messias J., Millan A., Salgado I., Santos P., Baia C., Canotilho R., Correia A.M., Ferreira P.A.P., Peyroteo M., Videira J.F., Bezede C., Chitul A., Ciofic E., Cristian D., Grama F., Pirtea L., Secosan C., Bonci E., Gata V., Titu S., Ginghina O., Iordache N., Iosifescu R.V., Kazachenko E., Markaryan D., Rodimov S., Tsarkov P., Tulina I., Litvina Y., Provozina A., Agapov M., Galliamov E., Kakotkin V., Kubyshkin V., Alshahrani M., Alsharif F., Eskander M., Al R.R., Majrashi S., Mashat A., Akeel N., Alharthi M., Aljiffry M., Basendowah M., Farsi A., Ghunaim M., Khoja A., Maghrabi A., Malibary N., Nassif M., Nawawi A., Saleem A., Samkari A., Trabulsi N., Al A.S., Alghamdi M., Alnumani T., Nasser M., Said B.A., Alhefdhi A., Almalik O., Alomair A., Alotaibi N., Alresaini F., Alsalamah R., Alsobhi S., Mahasin Z., Othman E., Velagapudi S., Ghedan S., Alharthi R., Awad S., Sharara M., Abdelrahman S., Althobaiti W., Al H.H., Alkarak S., Alqannas M., Alyami M., Alzamanan M., Cortes G.D., Elawad A., Alaamer O., Alriyees L., Alselaim N., Abdulkareem A., Ajlan A., Akkour K., Al-Habib A., Al-Khayal K., Alatar A., Alburakan A., Alhalal H., Alhassan B., Alhassan N., Alobeed O., Alsaif A., Alsaif F., Alshammari S., Alshaygy I., Barry M., Bin N.A., Bin T.T., Bokhari A., Elwatidy S., Helmi H., Madkhali A., Nouh T., Rabah P.D., Zubaidi A., Paunovic I., Slijepcevic N., Aleksic L., Antic A., Barisic G., Ceranic M., Galun D., Grubac Z., Jelenkovic J., Kecmanovic D., Kmezic S., Knezevic D., Krivokapic Z., Latincic S., Markovic V., Matic S., Miladinov M., Pavlov M., Pejovic I., Tadic B., Vasljevic J., Velickovic D., Zivanovic M., Perovic M., Srbinovic L., Andrijasevic S., Bozanovic T., Cerovic P.R., Dokic M., Janjic T., Jeremic K., Kadija S., Ladjeviclikic I., Mirkovic L., Pantovic S., Pilic I., Radojevic M., Stefanovic A., Vidakovic S., Vilendecic Z., Antic S., Dunderovic D., Jelovac D., Jezdic Z., Konstantinovic V., Kotlar B., Kuzmanovic C., Lazic M., Petrovic M., Popovic F., Pucar A., Romic M., Sumrak S., Vujanac V., Bascarevic V., Bogdanovic I., Grujicic D., Ilic R., Milicevic M., Milisavljevic F., Miljkovic A., Paunovic A., Scepanovic V., Stanimirovic A., Todorovic M., Jotic A., Milovanovic J., Trivic A., Bumbasirevic U., Dzamic Z., Kajmakovic B., Prijovic N., Zivkovic M., Buta M., Cvetkovic A., Djurisic I., Gacic S., Goran M., Inic Z., Jeftic N., Jevric M., Jokic V., Markovic I., Milanovic M., Nikolic S., Pejnovic L., Savkovic N., Spurnic I., Stevic D., Stojiljkovic D., Vucic N., Zegarac M., Karamarkovic A., Kenic M., Kovacevic B., Krdzic I., Milutinovic V., Chan C.W., Lieske B., Galis B., Simko K., Almgla N., Bernon M., Boutall A., Cairncross L., Herman A., Hilton T., Jonas E., Kloppers C., Malherbe F., Mugla W., Nel D., Rayamajhi S., Van W.T., Vogel J., Castano-Leon A.M., Delgado F.J., Eiriz F.C., Espino S.-I.M., Esteban S.O., Garcia P.D., Gomez P., Jimenez-Roldan L., Lagares A., Moreno-Gomez L., Paredes I., Perez N.A., Sanchez A.G., Santas M., Fernandez R.P., Paniagua G.S.M., Sanchez-Santos R., Vigorita V., Acrich E., Baenasanfeliu E., Barrios O., Golda T., Santanach C., Serrano-Navidad M., Sorribasgrifell M., Vives R.V., Escola D., Jimenez A., Cayetano P.L., Gomez F.L., Artigues E., Bernal-Sprekelsen J.C., Catalabauset J.C., Collera P., Diaz D.G.R., Farre F.R., Flores C.R., Gomez D.C.J., Guardia N., Guariglia C.A., Osorio A., Sanchez J.R., Sanchon L., Soto M.C., Albi M.B., Garcia V.J.E., Alonso-Lamberti L., Assaf M., Baeza P.N., Carabias A., Garcia-Quijada J., Huertas F.M.A., Jimenez M.J., Jimenez V., Jover J.M., Landeoaguero S.A., Leon R., Martin S.M., Perez S.V., Ponce S., Rodriguez J.L., Salazar A., Valle R.A., Aguado H., Aldecoaansorregui I., Bravo I.R., De L.F., Di S.A., Diaz-Feijoo B., Ensenat N.J., Fabregas N., Ferres A., Gil I.B., Gonzalez S.J., Gracia I., Hoyos C.J., Lacy A.M., Langdon C., Momblan D., Morales X., Oleaga L., Otero A., Pedrosa L., Poblete C.J., Reyes F.L., Roldan R.P., Rumia-Arboix J., Tercero-Uribe A.I., Topczewski T.E., Torales J., Torne A., Torne R., Turrado-Rodriguez V., Valero R., Valverde S., Anula R., Cano-Valderrama O., Del C.M.M., Diez-Valladares L., Dominguez I., Dziakova J., Garcia A.M., Garcia R.E., Gomez L.L., Muguerza J.M., Pizarro M.J., Saez C.P., Sanchez D.P.C., Sanchez-Pernaute A., Sanz O.G., Sanz-Lopez R., Torres A., Garces-Albir M., Lopez F., Martin-Arevalo J., Moro-Valdezate D., Pla-Marti V., Beltran D.H.J., De A.A.B., Gomez S.T., Jezieniecki C., Nunez D.B.H., Ortiz D.S.A.F., Romero D.D.A., Ruiz S.M., Trujillo D.J., Vazquez F.A., Lora-Cumplido P., Sosa M.V., Gonzalez-Gonzalez E., Minaya B.A., Alonso D.L.F.N., Cazadorlabat M., Cecchini L., Espinosa C.A., Jimenez T.M., Lopez C.A., Mancebo G., Martorell P., Munarriz M., Grau-Talens E.J., Martin-Perez B., Benavides B.J., Carrasco P.M., Fernandez P.V., Fernandez-Lopez A., Garcia E.D., Garcia P.V., Garcia S.V., Gimenezfrances C., Gonzalez V.F., Gurrea E., Lopez-Morales P., Marco G.A., Martinez A.J., Medina E., Munoz C.J., Parra B.P., Pena R.E., Ramirez F.M., Ruiz-Marin M., Sanchez R.C., Valero S.M., Estaire G.M., Fernandez C.A., Garcia S.E., Jimenez H.E., Martinez-Pinedo C., Munoz-Atienza V., Padilla-Valverde D., Picon R.R., Redondo C.F., Sanchez-Garcia S., Sanchez-Pelaez D., Colombari R.C., Del V.E., Fernandez M., Lozano L.P., Rey V.C., Steiner M.A., Tudela M., Zorrillaortuzar J., Alcaide M.F., Garcia P.J., Troncoso P.P., Mora-Guzman I., Abellan M., Achalandabasoboira M., Jorba R., Membaikuga R., Olona C., Sales M.R., Cavalle B.P., Gavaldapellice M.G.P., Salinas P.J., Aragon A.E., Barbier L., Cajavivancos P., Gainza A., Garcia G.J., Mallabiabarrenaormaechea G., Marin H., Martin P.P., Melchor C.I., Prieto C.M., Rodriguez F.A., Villalabeitiaateca I., De A.O.U., Duran B.M., Fernandez P.F., Ibanez-Aguirre F.J., Sanz L.A., Ugarte-Sierra B., De L.H.R.A., Di M.M., Garcia S.J., Martin-Perez E., Munoz D.N.J., Calvo E.P., Guillamotruano P., Colao G.L., Diaz P.D., Esteban A.E., Galindo J.P., Gutierrez S.M., Hernandez B.M., Serrano G.J., Alonso P.A., Dieguez B., Garcia-Conde M., Hernandez-Garcia M., Losada M., Chiesa-Estomba C.M., Gonzalez G.J., Larruscain E., Sistiaga-Suarez J.A., Alvarez E., Chavarrias N., Frias L., Gegundez S.A., Gortazar S., Gracia M., Guevara J., Hernandez G.A., Loayza A., Maria D.D., Marti C., Melendez M., Moreno-Palacios E., Perez Y., Prieto N.M., Ramos-Martin P., Rubio-Perez I., Saavedra J., Sanchez-Mendez J.I., Siegrist R.J., Urbieta A., Zapardiel I., Cantalejodiaz M., De M.A.M., Duque-Mallen V., Gascon F.I., Gonzalez-Nicolas T.M., Gracia-Roche C., Herrero L.M., Jariod F.U., Lanzon A., Martinez G.A., Matute M., Redondo C., Sanchez F.N., Sanchez-Rubio M., Santero-Ramirez M.S., Saudi S., Simon S.M., Uson-Bouthelier T., Blazquez M.A., Diez A.M., Garcia-Loarte G.E., Garcia-Moreno N.F., Gutierrez C.A., Hernandez P., Lasa I., Mendoza-Moreno F., Morales P.N., Ovejero M.E., Vera M.C., Acebes G.F., Bailon M., Bueno C.A., Choolanibhojwani E., Marcos-Santos P., Miguel T., Pacheco S.D., Perez-Saborido B., Sanchez G.J., Tejero-Pintor F.J., Alconchel F., Conesa A., Gil M.J., Gutierrez F.A., Lopez A.A., Nicolas-Lopez T., Ramirez R.P., Roca C.M., Rodrigues K., Ruiz M.J., Soriano A.I., Cano A., Capitan-Morales L., Cintas C.J., Gomez-Rosado J., Oliva M.F., Perez S.M., Rio L.F., Torres A.C., Valdes-Hernandez J., Cholewa H., Domingo S., Frasson M., Lago V., Marina M.T., Martinez C.C., Sancho-Muriel J., Landaluce-Olavarria A., Lecumberri D., Abad G.A., Abad-Motos A., Martinez-Hurtado E., Ripolles-Melchor J., Ruiz E.A., Cuadrado-Garcia A., Garcia-Sancho T.L., Heras A.J., Mate P., Ortega V.I., Picardo A.L., Rojo L.J., Sanchez C.F., Serralta D.C.D., Anchuelolatorre J., Cagigas F.C., Caina R.R., Gomez R.M., Hernanz F., Jimenofraile J., Martinez-Perez P., Poch C., Santarrufina M.S., Valbuena J.V., Moliner-Sanchez C., Pingarron-Martin L., Rey-Biel J., Ruiz M.I., Blas L.J., Cros B., Escartin J., Garcia E.J., Nogues A., Talal E.-A.I., Yanez C., Cagigal O.E., Cervera I., Diaz P.P., Elena G.D.C.R., Enjuto D., Fernandez B.P., Garces G.R., Gonzalez J., Hernandez I., Herrera-Merino N., Marqueta D.S.M., Martinez P.P., Perez G.M., Ramos B.A., Rodriguez G.L., Bescos C., Brana I., Caimari B., De P.G.-C.A., Duran-Valles F., Espin-Basany E., Giralt L.D.S.J., Pamias J., Prat N., Pujol P.R., Saezbarba M., Arulanantham A., Bandara G.B.K., Jayarajah U., Ravindrakumar S., Rodrigo V.S., Srishankar S., Elbe P., Lindqvist E.K., Taflin H., Alga A., Heinius G., Nordberg M., Pieniowski E., Gkekas I., Lofgren N., Sund M., Arigoni M., Bernasconi M., Christoforidis D., Di G.M., La R.D., Mongelli F., Chevallay M., Dwidar O., Gialamas E., Sauvain M., Klenke F., Kollar A., Kurze C., Bachler T., Crugnale A.S., Giardini M., Guglielmetti L., Peros G., Solimene F., Aghayeva A., Hamzaoglu I., Sahin I., Akaydin E., Aliyeva Z., Aytac E., Baca B., Dulgeroglu O., Ozben V., Ozmen B.B., Uras C., Arikan A.E., Bilgin I.A., Bozkirli B., Ceyhan G.O., Kara H., Karahasanoglu T., Celik H., Meydanli M.M., Akilli H., Ayhan A., Kuscu E., Onan M.A., Akgor U., Dincer H.A., Erol T., Gultekin M., Orhan N., Ozgul N., Salman M.C., Soyak B., Alhamed A., Ergun S., Ozcelik M.F., Sanli A.N., Uludag S.S., Velidedeoglu M., Zengin A.K., Bozkurt M.A., Kara Y., Kocatas A., Cimenoglu B., Demirhan R., Saracoglu K., Azamat I.F., Balik E., Bugra D., Giray B., Kulle C.B., Taskiran C., Vatansever D., Gozal K., Guler S.A., Koken H., Tatar O.C., Utkan N.Z., Yildirim A., Yuksel E., Akin E., Altintoprak F., Bayhan Z., Cakmak G., Capoglu R., Celebi F., Demir H., Dikicier E., Firat N., Gonullu E., Kamburoglu M.B., Kocer B., Kucuk I.F., Mantoglu B., Colak E., Kucuk G.O., Uyanik M.S., Goksoy B., Bozkurt E., Citgez B., Mihmanli M., Tanal M., Yetkin G., Akalin M., Arican C., Avci E.K., Aydin C., Demirliatici S., Emiroglu M., Kaya T., Kebabci E., Kilinc G., Kirmizi Y., Ogucu H., Salimoglu S., Sert I., Tugmen C., Tuncer K., Uslu G., Yesilyurt D., Karaman E., Kolusari A., Yildiz A., Benson O., Lule H., Agilinko J., Ahmeidat A., Barabasz M., Bekheit M., Cheung L.K., Colloc T., Cymes W., Elhusseini M., Gradinariu G., Hannah A., Kamera B.S., Mignot G., Shaikh S., Sharma P., Abu-Nayla I., Agrawal A., Al-Mohammad A., Ali S., Ashcroft J., Azizi A., Baker O., Balakrishnan A., Byrne M., Cotter A., Coughlin P., Davies R.J., Durrani A., Elshaer M., Fordington S., Forouhi P., Georgiades F., Grimes H., Habeeb A., Hudson V., Irune E., Jah A., Khan D.Z., Kyriacou H., Liau S., Luke L., Mahmoud R., Mannion R., Masterson L., Mitrofan C.G., Mohan M., Morris A., Murphy S., O'Neill R., Price S., Pushpa-Rajah J., Raby-Smith W., Ramzi J., Rooney S., Santarius T., Singh A., Tan X.S., Townson A., Tweedle E., Walker C., Waseem S., Yordanov S., Jones T., Kattakayam A., Loh C., Lunevicius R., Pringle S., Schache A., Sheel A., Rossborough C., Angelou D., Choynowski M., McAree B., McCanny A., Neely D., Tutoveanu G., Ahad S., De L.C.M.M., Mosley F., Oktseloglou V., Alanbuki A., Patel M., Shabana A., Perera E., Raveendran D., Ravi-Shankar K., Thiruchelvam J., Arrowsmith L., Campbell W., Grove T., Kontovounisios C., Warren O., Rolland P., Aggarwal A., Brown S., Jelley C., Neal N., Clifford R., Eardley N., Krishnan E., Manu N., Martin E., Roy M.S., Serevina O.L., Smith C., Bordenave M., Houston R., Putnam G., Robson A., Tustin H., Emslie K., Labib P.L., Miller D., Minto G., Natale J., Nwinee H., Panahi P., Rogers L., Abubakar A., Akhter R.M., Ko K.Y.K., O'Brien H., Sasapu K., Woodun H., Inglis R., Ng H.J., De G.R.A., Ghazali N., Lambert J., Markose G., Math S., Sarantitis I., Shrestha D., Sultana A., Taggarsi M., Timbrell S., Vaz O.P., Vitone L., Day A., Dent H., Fahim M., Waheed S., Hunt A., Laskar N., Gupta A., Steinke J., Thrumurthy S., Massie E., McGivern K., Rutherford D., Wilson M., Hardie J., Kazzaz S., Handa S., Kaushal M., Kler A., Patel P., Redfern J., Tezas S., Aawsaj Y., Amonkar S., Blackwell L., Blake D., Carter J., Emerson H., Fisher A., Katory M., Korompelis P., McCormick W., Mustafa A., Pearce L., Ratnavelu N., Reehal R., Kretzmer L., Lalou L., Manku B., Parwaiz I., Stafford J., Abdelkarim M., Asqalan A., Gala T., Ibrahim S., Maw A., Mithany R., Morgan R., Sundaram V.G., Ang K., Chowdhry M.F., Mohammad A., Nakas A., Rathinam S., Boal M., Brown O., Dwerryhouse S., Higgs S., Boyd E., Irvine V., Kirk A., Bakolas G., Boulton A., Chandock A., Kumar M., Agoston P., Bille A., Challacombe B., Fraser S., Harrison-Phipps K., King J., Mehra G., Mills L., Najdy M., Nath R., Okiror L., Pilling J., Rizzo V., Routledge T., Sayasneh A., Stroman L., Wali A., Fehervari M., Habib N., Hamrang-Yousefi S., Jawad Z., Jiao L., Pai M., Ploski J., Rajagopal P., Saso S., Sodergren M., Spalding D., Laws S., Hardie C., McNaught C., Alam R., Budacan A., Cahill J., Kalkat M., Karandikar S., Kenyon L., Naumann D., Ayorinde J., Chase T., Cuming T., Ghanbari A., Humphreys L., Tayeh S., Aboelkassem I.A., Bichoo R., Cao H., Chai A.K.W., Choudhury J., Evans C., Fitzjohn H., Ikram H., Langstroth M., Loubani M., McMillan A., Nazir S., Qadri S.S.A., Robinson A., Ross E., Sehgal T., Dixon J., Dunning J., Freystaetter K., Jha M., Lester S., Madhavan A., Thulasiraman S.V., Viswanath Y., Curl-Roper T., Delimpalta C., Liao C.C.L., Velchuru V., Westwood E., Belcher E., Bond-Smith G., Chidambaram S., Fasanmade K., Fraser L., Fu H., Ganau M., Gore S., Graystone J., Jeyaretna D., Khatkar H., Lami M., Maher M., Mastoridis S., Mihai R., Piper R., Prabhu S., Risk O.B.F., Selbong U., Shah K., Smillie R., Soleymanimajd H., Sravanam S., Stavroulias D., Tebala G.D., Vatish M., Verberne C., Wallwork K., Winter S., Bhatti M.I., Boyd-Carson H., Elsey E., Gemmill E., Herrod P., Jibreel M., Lenzi E., Saafan T., Sapre D., Sian T., Watson N., Athanasiou A., Bourke G., Bradshaw L., Coe P., Costigan F., Elkadi H., Johnstone J., Kanatas A., Kantola V., Kaufmann A., Laios A., Lam S., MacInnes E., Munot S., Nahm C., Otify M., Pompili C., Smith I., Theophilou G., Toogood G., Wade R., Ward D., West C., Annamalai S., Ashmore C., Boddy A., Hossain T., Kourdouli A., Gvaramadze A., Jibril A., Prusty L., Thekkinkattil D., Askari A., Cirocchi N., Kudchadkar S., Patel K., Sagar J., Shaw S., Talwar R., Abdalla M., Edmondson R., Ismail O., Jones D., Newton K., Stylianides N., Aderombi A., Andaleeb U., Bajomo O., Beatson K., Garrett W., Mehmood M., Ng V., Al-Habsi R., Divya G.S., Keeler B., Al-Sarireh B., Egan R., Harries R., Henry A., Kittur M., Li Z., Parkins K., Soliman F., Spencer N., Thompson D., Burgess C., Gemmell C., Grieco C., Hollyman M., Hunt L., Morrison J., Ojha S., Ryan N., Abbadessa F., Barnard S., Dawe N., Hammond J., Mahmoud A.F., McPherson I., Mellor C., Moir J., Pandanaboyana S., Powell J., Rai B., Roy C., Sachdeva A., Saleh C., Tingle S., Williams T., Manickavasagam J., McDonald C., McGrath N., McSorley N., Ragupathy K., Ramsay L., Solth A., Kakisi O., Seebah K., Shaikh I., Sreedharan L., Youssef M., Shah J., Ameerally P., McLarty N., Mills S., Shenfine A., Sahnan K., Abu J., Addae-Boateng E., Bratt D., Brock L., Burnside N., Cadwell-Sneath S., Gajjar K., Gan C., Grundy C., Hallam K., Hassell K., Hawari M., Joshi A., Khout H., Konstantinidi K., Lee R.X.N., Nunns D., Schiemer R., Walton T., Weaver H., Whisker L., Williamson K., McVeigh J., Myatt R., Williams M.A., Kaur R., Michel M., Patil S., Ravindran S., Sarveswaran J., Scott L., Edmond M., King E., Bhangu A., Breik O., Cato L.D., Griffiths E., Idle M., Kamal M., Kisiel A., Kulkarni R., Mak J.K.C., Martin T., Parente A., Parmar S., 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Chew D., Crank M., Ilenkovan N., MacDonald M., Narice B., Rominiyi O., Thompson A., Varley I., Drake T., Harrison E., Linder G., Mayes J., McGregor R., Skipworth R., Zamvar V., Hawkin P., Raymond T., Ryska O., Baron R., Dunne D., Gahunia S., Halloran C., Howes N., McKinney R., McNicol F., Russ J., Szatmary P., Tan J.R., Thomas A., Whelan P., Anzak A., Banerjee A., Fuwa O., Hughes F., Jayasinghe J.D., Knowles C., Kocher H., Leal S.I., Ledesma F.S., Minicozzi A., Navaratne L., Rahman R., Ramamoorthy R., Sohrabi C., Thaha M., Thakur B., Venn M., Yip V., Baumber R., Parry J., Evans S., Jeys L., Morris G., Parry M., Ahmadi N., Aresu G., Barrett-Brown Z.M., Durio Y.H., Gearon D., Hogan J., King M., Peryt A., Pradeep I.S., Adishesh M., Atherton R., Baxter K., Brocklehurst M., Chaudhury M., Krishnamohan N., McAleer J., Owens G., Parkin E., Patkar P., Phang I., Aladeojebi A., Ali M., Barmayehvar B., Gaunt A., Gowda M., Halliday E., Kitchen M., Mansour F., Thomas M., Zakai D., Abbassi-Ghadi N., Assalaarachchi H., Currie A., Flavin M., Frampton A., Hague M., Hammer C., Hopper J., Horsnell J., Humphries S., Kamocka A., Madhuri T.K., Preston S., Singh P., Stebbing J., Tailor A., Walker D., Aljanadi F., Jones M., Mhandu P., O'Donnell C., Turkington R., Al-Ishaq Z., Bhasin S., Bodla A.S., Burahee A., Crichton A., Fossett R., Pigadas N., Pickford S., Rahman E., Snee D., Yassin N., Fountain D., Hasan M.T., Karabatsou K., Laurente R., Pathmanaban O., Al-Mukhtar A., Giblin A., Kelty C., Lee M., Lye G., Newman T., Sharkey A., Steele C., Sureshkumar S.N., Whitehall E., Athwal R., Baker A., Jones L., Konstantinou C., Ramcharan S., Vatish J., Wilkin R., Ethunandan M., Sekhon G.K., Shields H., Singh R., Wensley F., Lyons A., Abbott T., Anwar S., Ghufoor K., Chung E., Hagger R., Hainsworth A., Karim A., Owen H., Ramwell A., Williams K., Baker C., Davies A., Gossage J., Kelly M., Knight W., Hall J., Harris G., James G., Kang C., Lin D.J., Rajgor A.D., Royle T., Scurrah R., Steel B., Watson L.J., Choi D., Hutchison R., Jain A., Luoma V., Marcus H., May R., Menon A., Pramodana B., Webber L., Aneke I.A., Asaad P., Brown B., Collis J., Duff S., Khan A., Moura F., Wadham B., Warburton H., Elmoslemany T., Jenkinson M., Millward C., Zakaria R., McCluney S., Parmar C., Shah S., Allison J., Babar M.S., Collard B., Goodrum S., Lau K., Scott R., Thomas E., Whitmore H., Balasubramaniam D., Jayasankar B., Kapoor S., Ramachandran A., Elhamshary A., Imam S.M.B., Kapriniotis K., Lindsay J., Rakhshani-Moghadam S., Beech N., Chand M., Green L., Kalavrezos N., Kiconco H., McEwen R., Schilling C., Sinha D., Pereca J., Chopra S., Egbeare D., Thomas R., Combellack T., Jones S.E.F., Kornaszewska M., Mohammed M., Sharma A., Tahhan G., Valtzoglou V., Williams J., Eskander P., Gash K., Gourbault L., Hanna M., MacCabe T., Newton C., Olivier J., Rozwadowski S., Teh E., West D., Al-Omishy H., Baig M., Bates H., Di T.G., Dickson K., Dunne N., Gill C., Howe D., Jeevan D., Khajuria A., Martin-Ucar A., McEvoy K., Naredla P., Robertson S., Sait M., Sarma D.R., Shanbhag S., Shortland T., Simmonds S., Skillman J., Tewari N., Walton G., Akhtar M.A., Brunt A., McIntyre J., Milne K., Rashid M.M., Sgro A., Stewart K.E., Turnbull A., Aguilar G.M., Talukder S., Boyle C., Fernando D., Gallagher K., Laird A., Tham D., Bath M., Patki P., Tanabalan C., Arif T., Magee C., Nambirajan T., Powell S., Vinayagam R., Flindall I., Hanson A., Mahendran V., Green S., Lim M., MacDonald L., Miu V., Onos L., Sheridan K., Young R., Alam F., Griffiths O., Houlden C., Jones R., Kolli V.S., Lala A.K., Leeson S., Peevor R., Seymour Z., Chen L., Henderson E., Brown K., Fleming D., Heron C., Hill C., Kay H., Leede E., McElhinney K., Olson K., Osterberg E.C., Riley C., Srikanth P., Thornhill M., Blazer D., Dilalla G., Hwang E.S., Lee W., Lidsky M., Plichta J., Rosenberger L., Scheri R., Turnage K., Visgauss J., Zani S., Farma J., Clark J., Kwon D., Etchill E., Gabre-Kidan A., Jenny H.E., Kent A., Ladd M., Long C., Malapati H., Margalit A., Rapaport S., Rose J., Stevens K., Tsai L., Vervoort D., Yesantharao P., Dehal A., Klaristenfeld D., Huynh K., Brown L., Mullinax J., Gusani N., Hazelton J., Maines J., Oh J.S., Ssentongo A., Ssentongo P., Azam M., Choudhry A., Marx W., Fleming J., Fuson A., Gigliotti J., Ovaitt A., Ying Y., Abel M.K., Andaya V., Bigay K., Boeck M.A., Chern H., Corvera C., El-Sayed I., Glencer A., Ha P., Hamilton B.C.S., Heaton C., Hirose K., Jablons D.M., Kirkwood K., Kornblith L.Z., Kratz J.R., Lee R., Miller P.N., Nakakura E., Nunez-Garcia B., O'Donnell R., Ozgediz D., Park P., Robinson B., Sarin A., Sheu B., Varma M., Wai K., Wustrack R., Xu M.J., Beswick D., Goddard J., Manor J., Song J., Fullmer T., Gaskill C., Gross N., Kiong K., Roland C.L., Zafar S.N., Abdallah M., Abouassi A., Almasri M., Kulkarni G., Marwan H., Mehdi M., Aoun S., Ban V.S., Batjer H.H., Caruso J., Abbott D., Acher A., Aiken T., Barrett J., Foley E., Schwartz P., Hawkins A., Maiga A., Laufer J., Scasso S., Zweroncy, A., Glasbey, J, Omar, O, Nepogodiev, D, Minaya-Bravo, A, Bankhead-Kendall, B, Fiore, M, Futaba, K, Gujjuri, R, Isik, A, Kaafarani, H, Kamarajah, S, Li, E, Loffler, M, Mclean, K, Oumaima, O, Faustin, N, Sohei, S, Shaw, R, Simoes, J, Stewart, G, Tabiri, S, Trout, I, Bhangu, A, Siaw-Acheampong, K, Benson, R, Bywater, E, Chaudhry, D, Dawson, B, Evans, J, Heritage, E, Jones, C, Khatri, C, Khaw, R, Keatley, J, Knight, A, Lawday, S, Mann, H, Marson, E, Mckay, S, Mills, E, Pellino, G, Picciochi, M, Taylor, E, Tiwari, A, Venn, M, Wilkin, R, Aneel, B, Smart, N, Gallo, G, Moug, S, Pata, F, Pockney, P, Saverio, S, Vallance, A, Vimalchandran, D, Roberts, K, Isaac, J, Edwards, J, Coonar, A, Marchbank, A, Caruana, E, Layton, G, Patel, A, Brunelli, A, Ford, S, Desai, A, Gronchi, A, Almond, M, Tirotta, F, Sinziana, D, Price, S, Fountain, D, Jenkinson, M, Hutchinson, P, Marcus, H, Piper, R, Lippa, L, Servadei, F, Esene, I, Freyschlag, C, Neville, I, Rosseau, G, Schaller, K, Demetriades, A, 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I., Martins dos Santos G., Ribeiro V. I., Baptista V. H., Melo Neves J. P., Bandovas J. P., Figueiredo de Barros I., Maciel J., Silveira Nunes I., Peralta Ferreira M., Rio Rodrigues L., Sousa Fernandes M., Soares A. C., Pmdd S., Vieira Paiva Lopes A. C., Mendes J. R., Abreu da Silva A., Costa Santos D., Deus A. C., Grilo J. V., Corte Real J., Lima M. J., Matos Costa P., Brito da Silva F., Baiao J. M., Martins Jordao D., Vieira Caroco T., Correia A. M., Videira J. F., Escobar P., Maldonado Santiago M., Kassir R., Sauvat F., Iosifescu R. V., Al Raddadi R., Al Awwad S., Al Habes H., Cortes Guiral D., Bin Nasser A., Bin Traiki T., Rabah P. D., Cerovic Popovic R., Ladjevic Likic I., Chan C. W., Van Wyngaard T., Castano-Leon A. M., Delgado Fernandez J., Eiriz Fernandez C., Espino Segura-Illa M., Esteban Sinovas O., Garcia Perez D., Perez Nunez A., Sanchez Aniceto G., Fernandez Rodriguez P., Paniagua Garcia Senorans M., Baena Sanfeliu E., Sorribas Grifell M., Vives R. V., Cayetano Paniagua L., Gomez Fernandez L., Bernal-Sprekelsen J. C., Catala Bauset J. C., Diaz Del Gobbo R., Farre Font R., Flores Clotet R., Gomez Diaz C. J., Guariglia C. A., Sanchez Jimenez R., Soto Montesinos C., Albi Martin B., Garcia Villayzan J. E., Baeza Pintado N., Jimenez Miramon J., Jover J. M., Landeo Aguero S. A., Perez Simon V., Rodriguez J. L., Valle Rubio A., Aldecoa Ansorregui I., Bravo Infante R., De Lacy F. B., Di Somma A., Ensenat Nora J., Gil Ibanez B., Gonzalez Sanchez J. J., Hoyos Castro J. A., Lacy A. M., Poblete Carrizo J., Reyes Figueroa L. A., Roldan Ramos P., Tercero-Uribe A. I., Topczewski T. E., Del Campo Martin M., Garcia Alonso M., Garcia Romero E., Gomez Latorre L., Muguerza J. M., Pizarro M. J., Saez Carlin P., Sanchez del Pueblo C., Sanz Ortega G., Beltran de Heredia J., De Andres Asenjo B., Gomez Sanz T., Nunez Del Barrio H., Ortiz de Solorzano Aurusa F. J., Romero de Diego A., Ruiz Soriano M., Trujillo Diaz J., Sosa M. V., Minaya Bravo A. M., Cazador Labat M., Espinosa C. A., Jimenez Toscano M., Lopez Campillo A., Grau-Talens E. J., Benavides Buleje J. A., Carrasco Prats M., Fernandez P. V., Garcia Escudero D., Garcia Porcel V. J., Garcia Soria V., Gimenez Frances C., Gonzalez Valverde F. M., Marco Garrido A., Martinez Alonso J. A., Munoz Camarena J. M., Parra Banos P. A., Pena Ros E., Ramirez Faraco M., Sanchez Rodriguez C., Valero Soriano M., Estaire Gomez M., Fernandez Camunas A., Garcia Santos E. P., Jimenez Higuera E., Picon Rodriguez R., Redondo Calvo F. J., Colombari R. C., Lozano Lominchar P., Rey Valcarcel C., Zorrilla Ortuzar J., Alcaide Matas F., Garcia Perez J. M., Troncoso Pereira P., Achalandabaso Boira M., Memba Ikuga R., Sales Mallafre R., Cavalle Busquets P., Mgp G. P., Salinas Pena J., Aragon Achig E. J., Caja Vivancos P., Garcia Gutierrez J. J., Mallabiabarrena Ormaechea G., Martin Playa P., Melchor Corcostegui I., Prieto Calvo M., Rodriguez Fraga A., Villalabeitia Ateca I., De Andres Olabarria U., Duran Ballesteros M., Fernandez Pablos F. J., Ibanez-Aguirre F. J., Sanz Larrainzar A., De la Hoz Rodriguez A., Di Martino M., Garcia Septiem J., Munoz de Nova J. L., Calvo Espino P., Guillamot Ruano P., Colao Garcia L., Diaz Perez D., Esteban Agusti E., Galindo Jara P., Gutierrez Samaniego M., Serrano Gonzalez J., Alonso Poza A., Chiesa-Estomba C. M., Gonzalez Garcia J. A., Sistiaga-Suarez J. A., Garcia Pineda V., Gegundez Simon A., Hernandez Gutierrez A., Maria Dolores D. T., Prieto Nieto M. I., Sanchez-Mendez J. I., Siegrist Ridruejo J., Gascon Ferrer I., Gonzalez-Nicolas Trebol M. T., Herrero Lopez M., Jariod Ferrer U. M., Martinez German A., Sanchez Fuentes N., Simon Sanz M. V., Blazquez Martin A., Diez Alonso M., Garcia Rico E., Garcia-Loarte Gomez E., Garcia-Moreno Nisa F., Gutierrez Calvo A., Morales Palacios N., Ovejero Merino E., Vera Mansilla C., Acebes Garcia F., Bueno Canones A. D., Choolani Bhojwani E., Pacheco Sanchez D., Sanchez Gonzalez J., Gil Martinez J., Gutierrez Fernandez A. I., Lopez Abad A., Ramirez Romero P., Roca Calvo M. J., Ruiz Manzanera J. J., Soriano A. I., Cintas Catena J., Oliva Mompean F., Rio Lafuente F. D., Torres Arcos C., Marina Martin T., Martinez Chicote C., Landaluce-olavarria A., Abad Gurumeta A., Ruiz Escobar A., Garcia-Sancho Tellez L., Heras Aznar J., Ortega Vazquez I., Picardo A. L., Rojo Lopez J. A., Sanchez Cabezudo Noguera F., Serralta de Colsa D., Anchuelo Latorre J., Cagigas Fernandez C., Caina Ruiz R., Gomez Ruiz M., Jimeno Fraile J., Santarrufina Martinez S., Valbuena Jabares V., Ruiz Martin I., Blas Laina J. L., Garcia Egea J., Talal El-Abur I., Cagigal Ortega E. P., Diaz Pena P., Gdcr E., Fernandez Bernabe P., Garces Garcia R., Marqueta De Salas M., Martinez Pascual P., Perez Gonzalez M., Ramos Bonilla A., Rodriguez Gomez L., De Pablo Garcia-Cuenca A., Giralt Lopez de Sagredo J., Pujol Pina R., Gbk B., Rodrigo V. S., Lindqvist E. K., Di Giuseppe M., La Regina D., Crugnale A. S., Ozmen B. B., Arikan A. E., Bilgin I. A., Ceyhan G. O., Dincer H. A., Salman M. C., OZcelik M. F., Sanli A. N., Uludag S. S., Zengin A. K., Azamat I. F., Kulle C. B., Guler S. A., Tatar O. C., Utkan N. Z., Kucuk I. F., Kucuk G. O., Avci E. K., Demirli Atici S., Cheung L. K., Davies R. J., Khan D. Z., Mitrofan C. G., Pushpa-rajah J., Tan X. S., Mfi D. L. C. M., Roy Mahapatra S., Serevina O. L., Labib P. L., Kyk K., Ng H. J., De Gea Rico A., Vaz O. P., Sundaram Venkatesan G., Chowdhry M. F., Aboelkassem Ibrahim A., Akw C., Ssa Q., Thulasiraman S. V., Ccl L., Di Chiara F., Obf R., Tebala G. D., Bhatti M. I., Harky A., Shackcloth M., Divya G. S., Mahmoud Ali F., Rxn L., Jkc M., Pathanki A. M., Khan A. H., Tan K. L., Malcolm F. L., Hidalgo Salinas C., Machairas N., Pollok J. M., Raptis D. A., Xyda S. E., Macdonald M., Tan J. R., Leal Silva I., Ledesma F. S., Barrett-Brown Z. M., Durio Yates H., Pradeep I. S., Madhuri T. K., Bodla A. S., Hasan M. T., Al-mukhtar A., Sureshkumar Shah N., Sekhon G. K., Lin D. J., Rajgor A. D., Watson L. J., Aneke I. A., Mccluney S., Smb I., Sef J., Maccabe T., Al-omishy H., Di Taranto G., Sarma D. R., Stewart K. E., Aguilar Gonzalez M., Kolli V. S., Lala A. K., Osterberg E. C., Hwang E. S., Jenny H. E., Oh J. S., Abel M. K., El-sayed I., Bcs H., Kornblith L. Z., Kratz J. R., Miller P. N., Xu M. J., Roland C. L., Zafar S. N., Ban V. S., Batjer H. H., Apollo - University of Cambridge Repository, and Collaborative, COVIDSurg
Subjects: Lung Diseases, Male, AcademicSubjects/MED00910, COVID-19/diagnosis, Settore MED/18 - CHIRURGIA GENERALE, neoplasms, 030230 surgery, minorsurgical procedures, Medical and Health Sciences, Lung Disease, 0302 clinical medicine, Postoperative Complications, 030202 anesthesiology, aged, aged, 80 and over, COVID-19, elective surgical procedures, female, humans, lung diseases, male, middle aged, Nasopharynx, pandemics, postoperative complications, risk assessment, SARS-CoV-2, COVID-19 nucleic acid testing, Neoplasms, 80 and over, 030212 general & internal medicine, 610 Medicine & health, Lung, Cancer, Aged, 80 and over, Incidence (epidemiology), Confounding, Pulmonary Complication, Lung Diseases/*etiology, Neoplasms/surgery, General Medicine, Middle Aged, Elective Surgical Procedures/adverse effects, Oncology, Elective Surgical Procedures, 030220 oncology & carcinogenesis, COVID-19 Nucleic Acid Testing, Original Article, Female, Patient Safety, AcademicSubjects/MED00010, Elective Surgical Procedure, 6.4 Surgery, Human, Cohort study, medicine.medical_specialty, preoperative caresurgical procedures, Preoperative care, Risk Assessment, Article, COVIDSurg Collaborative, NO, Vaccine Related, 03 medical and health sciences, Clinical Research, Biodefense, medicine, Nasopharynx/*virology, Humans, Nasopharynx/virology, Elective surgery, Adverse effect, Pandemics, LS7_4, Aged, Pandemic, business.industry, Surgery, Sars Cov2, Prevention, No key words available, electivesurgical procedures, Lung Diseases/etiology, Evaluation of treatments and therapeutic interventions, Postoperative complication, operativenasopharynxsurgery specialtypulmonary complicationscancer surgerysars-cov-2covid-19coronavirus pandemic, Odds ratio, medicine.disease, Confidence interval, Surgery, COVID-19/*diagnosis, Emerging Infectious Diseases, Good Health and Well Being, Neoplasm, Postoperative Complication, preoperative caresurgical procedures, electivesurgical procedures, minorsurgical procedures, operativenasopharynxsurgery specialtypulmonary complicationscancer surgerysars-cov-2covid-19coronavirus pandemic, Elective Surgical Procedures/*adverse effects, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Background Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. Methods This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. Results Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. Conclusion Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas., This was an international cohort study of 8784 patients undergoing elective cancer surgery during the COVID-19 pandemic. Preoperative nasopharyngeal swab testing for SARS-CoV-2 was associated with a reduction in postoperative pulmonary complications. This was consistent for major surgery and in high-incidence areas, but with no proven benefit before minor surgery in low-incidence areas.
Published: 2021
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30. Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Author: Writing Group (denotes joint first author) James, C Glasbey (UK), Dmitri Nepogodiev (UK), Joana FF Simoes (Portugal), Omar Omar (UK), Elizabeth Li (UK), Mary, L Venn (UK), Mohammad Abou Chaar (Jordan), Vita Capizzi (Italy), Daoud Chaudhry (UK), Anant Desai (UK), Jonathan, G Edwards (UK), Jonathan, P Evans (UK), Marco Fiore (Italy), Jose Flavio Videria (Portugal), Samuel, J Ford (UK), Ian Ganyli (USA), Ewen, A Griffiths (UK), Rohan, R Gujjuri (UK), Angelos, G Kolias (UK), Haytham MA Kaafarani (USA), Ana Minaya-Bravo (Spain), Siobhan, C McKay (UK), Helen, M Mohan (Ireland), Keith Roberts (UK), Carlos San Miguel-M&#233, ndez (Spain), Peter Pockney (Australia), Richard Shaw (UK), Neil, J Smart (UK), Grant, D Stewart (UK), Sudha Sundar (UK), Raghavan Vidya (UK), Aneel, A Bhangu (UK, Statistical analysis Glasbey JC, Overall guarantor)., Omar, O (Lead statistician), Bhangu, A CovidSurg Operations Committee Kwabena Siaw-Acheampong, Ruth, A Benson, Edward, Bywater, Daoud, Chaudhry, Brett, E Dawson, Jonathan, P Evans, James, C Glasbey, Rohan, R Gujjuri, Emily, Heritage, Conor, S Jones, Sivesh, K Kamarajah, Chetan, Khatri, Rachel, A Khaw, James, M Keatley, Andrew, Knight, Samuel, Lawday, Elizabeth, Li, Harvinder, S Mann, Ella, J Marson, Kenneth, A McLean, Siobhan, C Mckay, Emily, C Mills, Dmitri, Nepogodiev, Gianluca, Pellino, Maria, Picciochi, Elliott, H Taylor, Abhinav, Tiwari, Joana FF Simoes, Isobel, M Trout, Mary, L Venn, Richard JW Wilkin, International Cancer Leads (denotes specialty Principal Investigators) James C Glasbey (Chair), Aneel Bhangu., Colorectal: Neil, J Smart, Ana, Minaya-Bravo, Susan, Moug, Dale, Vimalchandran, Abigail, Vallance, Peter, Pockney, Oesophagogastric: Ewen, A Griffiths, Richard PT Evans, Philip, Townend, Hepatopancreatobilary: Keith Roberts, Siobhan, McKay, John, Isaac, Sohei, Satoi, Thoracic: John Edwards, Aman, S Coonar, Adrian, Marchbank, Edward, J Caruana, Georgia, R Layton, Akshay, Patel, Alessandro, Brunelli, Sarcoma: Samuel Ford, Anant, Desai, Alessandro, Gronchi, Marco, Fiore, Max, Almond, Fabio, Tirotta, Sinziana, Dumitra, Neurosurgery: Angelos Kolias, Stephen, J Price, Daniel, M Fountain, Michael, D Jenkinson, Peter, Hutchinson, Hani, J Marcus, Rory, J Piper, Laura, Lippa, Franco, Servadei, Ignatius, Esene, Christian, Freyschlag, Iuri, Neville, Gail, Rosseau, Karl, Schaller, Andreas, K Demetriades, Faith, Robertson, Alex, Alamri, Head and neck: Richard Shaw, Andrew, G Schache, Stuart, C Winter, Michael, Ho, Paul, Nankivell, Juan Rey Biel, Martin, Batstone, Ian, Ganly, Breast: Raghavan Vidya, Alex, Wilkins, Jagdeep, K Singh, Dinesh, Thekinkattil, Gynaecology: Sudha Sundar, Christina, Fotopoulou, Elaine, Leung, Tabassum, Khan, Luis, Chiva, Jalid, Sehouli, Anna, Fagotti, Paul, Cohen, Murat, Gutelkin, Rahel, Ghebre, Thomas, Konney, Rene, Pareja, Rob, Bristow, Sean, Dowdy, Shylasree TS Rajkumar, Joe, Ng, Keiiji, Fujiwara, Urology: Grant, D Stewart, Benjamin, Lamb, Krishna, Narahari, Alan, McNeill, Alexandra, Colquhoun, John, McGrath, Steve, Bromage, Ravi, Barod, Veeru, Kasivisvanathan, Dissemination Committee Joana FF Simoes (Chair), Tobias Klatte., Tom EF Abbott, Michel, Adamina, Adesoji, O Ademuyiwa, Arnav, Agarwal, Ehab, Alameer, Derek, Alderson, Felix, Alakaloko, Markus, Albertsmeiers, Osaid, Alser, Muhammad, Alshaar, Sattar, Alshryda, Alexis, P Arnaud, Knut Magne Augestad, Faris, Ayasra, Jos&#233, Azevedo, Brittany, K Bankhead-Kendall, Emma, Barlow, Ruth, Blanco-Colino, Amanpreet, Brar, Kerry, A Breen, Chris, Bretherton, Igor Lima Buarque, Joshua, Burke, Mohammad, Chaar, Sohini, Chakrabortee, Peter, Christensen, Daniel, Cox, Moises, Cukier, Miguel, F Cunha, Giana, H Davidson, Salomone Di Saverio, Thomas, M Drake, John, G Edwards, Muhammed, Elhadi, Sameh, Emile, Shebani, Farik, J Edward Fitzgerald, Samuel, Ford, Tatiana, Garmanova, Gaetano, Gallo, Dhruv, Ghosh, Gustavo Mendon&#231, a Ata&#237, de Gomes, Gustavo, Grecinos, Ewen, A Griffiths, Madalegna, Gr&#252, ndl, Constantine, Halkias, Ewen, M Harrison, Intisar, Hisham, Peter, J Hutchinson, Shelley, Hwang, Arda, Isik, Pascal, Jonker, Haytham MA Kaafarani, Angelos, Kolias, Schelto, Kruijff, Ismail, Lawani, Hans, Lederhuber, Sezai, Leventoglu, Andrey, Litvin, Andrew, Loehrer, Markus, W L&#246, ffler, Maria Aguilera Lorena, Maria Marta Madolo, Piotr, Major, Janet, Martin, Hassan, N Mashbari, Dennis, Mazingi, Symeon, Metallidis, Helen, M Mohan, Rachel, Moore, David, Moszkowicz, Joshua, S Ng-Kamstra, Mayaba, Maimbo, Milagros, Niquen, Faustin, Ntirenganya, Maricarmen, Olivos, Kacimi, Oussama, Oumaima, Outani, Marie Dione Parreno-Sacdalanm, Francesco, Pata, Carlos Jose Perez Rivera, Thomas, D Pinkney, Willemijn van der Plas, Ahmad, Qureshi, Dejan, Radenkovic, Antonio Ramos- De la Medina, Keith, Roberts, April, C Roslani, Martin, Ruteg&#229, Ir&#232, ne, Santos, Raza, Sayyed, Andrew, Schache, Andreas, A Schnitzbauer, Seyi-Olajide, Justina O., Neil, Sharma, Richard, Shaw, Sebastian, Shu, Kjetil, Soreide, Antonino, Spinelli, Grant, D Stewart, Malin, Sund, Sudha, Sundar, Stephen, Tabiri, Georgios, Tsoulfas, Gabrielle, H van Ramshorst, Raghavan, Vidya, Dale, Vimalachandran, Oliver, J Warren, Duane, Wedderburn, Naomi, Wright, EuroSurg, European Society of Coloproctology (ESCP), Global Initiative for Children&#8217, s Surgery (GICS), GlobalSurg, GlobalPaedSurg, ItSURG, PTSurg, SpainSurg, Italian Society of Colorectal Surgery (SICCR), Association of Surgeons in Training (ASiT), Irish Surgical Research Collaborative (ISRC), Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), Collaborators (denotes Site Principal Investigators) Argentina: Allemand C, Italian Society of Surgical Oncology (SICO)., Boccalatte, L, Figari, M, Lamm, M, Larra&#241, aga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L (Hospital Italiano De Buenos Aires), Alurralde, C, Caram, El, Eskinazi, D, Mendoza, Jp, Usandivaras M (Sanatorio, 9 De Julio Sa), Badra, R, Esteban, A, Garc&#237, a, Js, a, Pm, Gerchunoff, Ji, Lucchini, Sm, NIgra, Ma, Armenia: Hovhannisyan T, Vargas L (Sanatorio Allende)., Australia: Gould T, Stepanyan A (Nairi Medical Center)., Gourlay, R, Griffiths, B (Calvary Mater Newcastle), Gananadha S, McLaren M (Canberra Hospital), Cecire, J, Joshi, N, Salindera, S, Sutherland, A (Coffs Harbour Health Campus), Ahn, Jh, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H (Concord Repatriation General Hospital), Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, Vo UG (Fiona Stanley Hospital), Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Lam, Yh, Ong, Bs, Szpytma, M, Watson, D (Flinders Medical Centre), Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, Nolan, Gj, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M (Gold Coast University Hospital), Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N (John Hunter Hospital), Elliott M, Phung D (Lifehouse), Phan D, Townend D (Lismore Base Hospital), Bong C, Gundara J (Logan Hospital), Frankel, A (Princess Alexandra Hospital), Bowman S, Guerra GR (Queen Elizabeth Ii Jubilee Hospital), Bolt, J, Buddingh, K, Dudi-Venkata, Nn, Jog, S, Kroon, Hm, Sammour, T, Smith, R, Stranz, C (Royal Adelaide Hospital), Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B (Royal Brisbane And Women&#8217, s Hospital), Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, Mw, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Austria: Lanner M (Kardinal Schwarzenberg Klinikum), Wright G (St Vincent&#8217, s Hospital)., K&#246, nigsrainer, I (Landeskrankenhaus Feldkirch), Bauer, M, Freyschlag, C, Kafka, M, Messner, F, 214, fner, D, Tsibulak, I (Medical University Of Innsbruck), Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, hlberger, L, Presl, J, Azerbaijan: Namazov &#304, Wimmer A (Paracelsus Medical University Salzburg)., Barbados: Barker D, Samadov E (Leyla Medical Centerl)., Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O&#8217, Shea, M, Padmore, G, Paquette, N, Phillips, E, John S, St., Belgium: Flamey N, Walkes K (Queen Elizabeth Hospital)., Pattyn, P (Az Delta), Oosterlinck, W, Van den Eynde, J, Brazil: Gatti A, Van den Eynde R (Uz Leuven)., Nardi, C, Oliva, R (Hospital Geral De Pirajussara), De Cicco, R (Instituto De C&#226, ncer Dr Arnaldo Vieira De Carvalho), Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, Canada: Kidane B, Terra RM (Instituto Do C&#226, ncer De Estado De S&#227, o Paulo). Bulgaria: Sokolov M (University Hospital Alexandrovska)., Srinathan, S (Health Sciences Centre), Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S (Jewish General Hospital), Dumitra, S, Kouyoumdjian, A (Mcgill University Health Center), Johnston B, Russell C (Saint John Regional Hospital), Demyttenaere, S, Mary&#8217, s Hospital), Garfinkle R (St., Abou-Khalil, J, Nessim, C, Colombia: Almeciga A, Stevenson J (The Ottawa Hospital). Chile: Heredia F (Cl&#237, nica Universitaria De Concepci&#243, n)., Fletcher, A, Merchan A (Centro De Investigaciones Oncol&#243, gicas Cl&#237, nica San Diego, - Ciosad), Puentes LO (Hospital San Jos&#233, Croatia: Ba&#269, i&#263, G, Mendoza Quevedo J (Subred Sur Occidente De Kennedy (Hospital De Kennedy))., Karlovi&#263, D, Kr&#353, ul, D, Zeli&#263, M (University Hospital Center Rijeka), Luksic I, Mamic M (University Hospital Dubrava), Bakmaz, B, 262, oza, I, Dijan, E, Katusic, Z, Mihanovic, J, Cyprus: Frantzeskou K, Rakvin I (Zadar General Hospital)., Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Czechia: Martinek L, Yiallourou A (Nicosia General Hospital)., Skrovina, M, Szubota, I (Hospital &amp, amp, Oncological Centre Novy Jicin), 381, ateck&#253, J (Slezsk&#225, Nemocnice V Opav&#283, P. o. ), Javurkova, V, Denmark: Avlund T, Klat J (University Hospital Ostrava)., Christensen, P, Harbjerg, Jl, Iversen, Lh, Kjaer, Dw, Kristensen, H&#248, Mekhael, M (Aarhus University Hospital), Ebbeh&#248, j, Al, Krarup, P, Schlesinger, N, Egypt: Abdelsamed A, Smith H (Bispebjerg Hospital)., Azzam, Ay, Salem, H, Seleim, A (Al Azhar University Hospitals), Abdelmajeed, A, Abdou, M, Abosamak, Ne, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elhoseiny, M, Elnemr, M, Elqasabi, Ms, Elsayed Hewalla ME, Elsherbini, I, Essam, E, Eweda, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, Ms, Ragab, M, Sabry, A, Saifeldin, H, Saleh Mesbah Mohamed Elkaffas, M, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K (Alexandria Main University Hospital), Attia, D, Kamal, N, Osman, N (Alexandria Medical Research Institute), Abbas, Am, Abd Elazeem HAS, Abdelkarem, Mm, Alaa, S, Ali, Ak, Ayman, A, Azizeldine, Mg, Elkhayat, H, elghazaly S, M., Monib, Fa, Nageh, Ma, Saad, Mm, Salah, M, Shahine, M, Yousof, Ea, Youssef, A (Assiut University Hospital), Eldaly, A (El-Menshawy Hospital), ElFiky, M, Nabil, A (Kasr Alainy Faculty Of Medicine, Cairo, University), Amira, G, Sallam, I, Sherief, M, Sherif, A (Misr Cancer Center), Abdelrahman, A, Aboulkassem, H, Ghaly, G, Hamdy, R, Morsi, A, Sherif, G (National Cancer Institute), Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, Sherif AE (National Liver Institute, Finland: Kauppila J, Menoufia University). Ethiopia: Bekele D (Maddawalabu University Goba Referral Hospital)., Sarjanoja, E (L&#228, nsi-Pohja Central Hospital), Helminen, O, Huhta, H, France: Beyrne C, Kauppila JH (Oulu University Hospital)., Jouffret, L, Lugans, L, Marie-Macron, L (Centre Hospitalier Avignon), Chouillard E, De Simone B (Centre Hospitalier Intercommunal Poissy Saint Germain En Laye), Bettoni, J, Dakp&#233, S, Devauchelle, B, Lavagen, N, Testelin, S (Chu Amiens), Boucher, S, Breheret, R, Gueutier, A, Kahn, A, K&#252, n-Darbois, J (Chu Angers), Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P (Chu Besan&#231, on), Chebaro, A, Drubay, V, El amrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, Pruvot, Fr, Truant, S, Zerbib, P (Chu Lille), Ballouhey, Q, Barrat, B, Laloze, J, Salle, H, Taibi, A, Usseglio, J (Chu Limoges), Bergeat D, Merdrignac A (Chu Rennes - General Surgery), Le Roy, B, Perotto, Lo, Scalabre, A (Chu Saint Etienne), Aim&#233, A, Ezanno, A, Malgras, B (Hia Begin), Bouche P, Tzedakis S (H&#244, pital Cochin - Aphp), Cotte, E, Glehen, O, Lifante, J (Hopital Lyon Sud), D&#8217, Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B (Hus, Pole H&#233, pato-Digestif, / Ihu- Strasbourg), Bardet, J, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Moumen, A, Pourcher, G, Seguin-givelet, A, Tribillon, E (Institut Mutualiste Montsouris), Duchalais, E, Espitalier, F, Ferron, C, Germany: Bork U, Malard O (Nantes University Hospital)., Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P (Carl-Gustav-Carus University, Dresden), Tu, Beyer, K, Kamphues, C, Lauscher, J, Loch, Fn, Schineis, C (Charit&#233, University Medicine, Campus Benjamin Franklin), Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J (Department of General, Visceral and Transplantation Surgery, Ludwig- Maximilians-Universitat Munich), Becker R, Jonescheit J (Heilig-Geist Hospital Bensheim), Pergolini I, Reim D (Klinikum Rechts Der Isar Tum School Of Medicine), Boeker, C, Hakami, I, Mall, J (Krh Nordstadt-Siloah Hospitals), Liokatis P, Smolka W (LMU Klinikum Campus Innenstadt), Nowak K, Reinhard T (Romed Klinikum Rosenheim), H&#246, lzle, F, Modabber, A, Winnand, P (University Hospital Aachen), Knitschke, M (University Hospital Giessen And Marburg), Kauffmann P, Wolfer S (University Hospital Goettingen / Universit&#228, tsmedizin Goettingen), Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R (University Hospital Halle (Saale)), Bertolani, E, nigsrainer, A, L&#246, ffler, Mw, Quante, M, Steidle, C, 220, berr&#252, ck, L, Yurttas, C (University Hospital Tuebingen), Betz, Cs, Bewarder, J, B&#246, ttcher, A, Burg, S, Busch, C, Gosau, M, Heuer, A, Izbicki, J, Klatte, To, Koenig, D, Moeckelmann, N, Nitschke, C, Priemel, M, Smeets, R, Speth, U, Thole, S, Uzunoglu, Fg, Vollkommer, T, Zeller, N (University Medical Center Hamburg- Eppendorf), Battista, Mj, Gillen, K, Hasenburg, A, Krajnak, S, Linz, V, Schwab, R (University Of Mainz, Greece: Angelou K, Department Of Gynaecology And Obstetrics)., Haidopoulos, D, Rodolakis, A (Alexandra General Hospital), Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A (Aretaieion Hospital), Antonopoulou, Mi, Manatakis, Dk, Tasis, N (Athens Naval And Veterans Hospital), Arkadopoulos, N, Danias, N, Economopoulou, P, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Selmani, J, Sidiropoulos, T, Tsaousis, V, Vassiliu, P (Attikon University General Hospital), Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G (Evaggelismos General Hospital), Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Koukoulis, G, Ntziovara, Am, Petropoulos, K, Soulikia, K, Tsiamalou, I, Zervas, K, Zourntou, S (General Hospital Of Larissa &#8220, Koutlimpaneio And Triantafylleio&#8221, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D (General University Hospital Of Larissa), Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G (George Papanikolaou General Hospital Of Thessaloniki), Karaitianos I, Tsirlis T (Henry Dunant Hospital Center), Charalabopoulos, A, Liakakos, T, Mpaili, E, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C (Laiko University Hospital), Anthoulakis, C, Christou, C, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D (Papageorgiou General Hospital), Athanasakis, E, Chrysos, E, Tsiaousis, J, Xenaki, S, Hong Kong: Futaba K, Xynos E (University Hospital Of Heraklion Crete And Interclinic Hospital Of Crete)., Ho, Mf, Hon, Sf, Mak, Twc, Ng SSM (Prince Of Wales Hospital), Hungary: Banky B, Foo CC (Queen Mary Hospital)., Ireland: Aremu M, Suszt&#225, k N (Szent Borb&#225, la K&#243, rh&#225, z)., Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L (Connolly Hospital Blanchardstown), Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Killeen, S, Lynch, N, McCarthy, A, Mustafa, H, Brien, S, Leary, P, Syed, Was, Vernon, L (Cork University Hospital), Callanan, D, Huang, L, Ionescu, A, Sheahan, P (South Infirmary Victoria University Hospital), Balasubramanian, I, Boland, M, Conlon, K, Evoy, D, Fearon, N, Gallagher, T, Geraghty, J, Heneghan, H, Kennedy, N, Maguire, D, McCartan, D, McDermott, Ew, Prichard, Rs, Winter, D (St Vincent&#8217, s University Hospital), Alazawi, D, Barry, C, Boyle, T, Butt, W, Connolly, Em, Donlon, N, Donohue, C, Fahey, Ba, Farrell, R, Fitzgerald, C, Kinsella, J, Larkin, Jo, Lennon, P, Maguire, Pj, Mccormick, P, Mehigan, Bj, Mohan, H, Nugent, T, Sullivan, H, Ravi, N, Reynolds, Jv, Rogers, A, Shokuhi, P, Smith, J, Smith, La, James&#8217, s Hospital), Timon C (St., Bashir, Y, Bass, G, Connelly, T, Earley, H, Elliott, Ja, Gillis, A, Kavanagh, D, Neary, P, riordan, J, Reynolds, Is, Rice, D, Ridgway, P, Umair, M, Whelan, M (Tallaght Hospital), Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, A, Hogan, A, Kerin, M, Lowery, A, McAnena, P, McKevitt, K, Nizami, K, Ryan, &#201, Samy, A (University Hospital Galway), Coffey, Jc, Cunningham, R, Devine, M, Nally, D, Peirce, C, Tormey, S (University Hospital Limerick), Hardy, N, Malley, S, Italy: Macina S (Asst Mantua), Ryan M (University Hospital Waterford/University College Cork)., Mariani, Nm, Opocher, E, Pisani Ceretti A (Asst Santi Paolo, E Carlo), Ferrari, F, Odicino, F, Sartori, E (Asst Spedali Civili, Ospedale Di Brescia), Cotsoglou C, Granieri S (Asst Vimercate), Bianco, F, Camillo&#8217, Colledan, M, Tornese, S, Zambelli MF (Asst-Papa Giovanni Xxiii- Bergamo), Bissolotti, G, Fusetti, S, Lemma, F (Azienda Ospedaliera Di Padova), Marino, M, Mirabella, A, Vaccarella, G (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo), Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, De Vincenti, R, Di Bella, A, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, Ringressi, Mn, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R (Azienda Ospedaliera Universitaria Careggi), Bassi, C, Campagnaro, T, Casetti, L, De Pastena, M, Esposito, A, Fontana, M, Guglielmi, A, Landoni, L, Malleo, G, Marchegiani, G, Nobile, S, Paiella, S, Pedrazzani, C, Rattizzato, S, Ruzzenente, A, Salvia, R, Turri, G, Tuveri, M (Azienda Ospedaliera Universitaria Integrata Di Verona), Bellora, P, Aloisio, G, Ferrari, M, Francone, E, Gentilli, S, Nikaj, H (Azienda Ospedaliero Universitaria Maggiore Della Carit&#224, Bianchini, M, Chiarugi, M, Coccolini, F, Di Franco, G, Furbetta, N, Gianardi, D, Guadagni, S, Morelli, L, Palmeri, M, Tartaglia, D (Azienda Ospedaliero Universitaria Pisana), Anania, G, Carcoforo, P, Chiozza, M, De Troia, A, Koleva Radica, M, Portinari, M, Sibilla, Mg, Urbani, A (Azienda Ospedaliero Universitaria Sant&#8217, anna), Fabbri, N, Feo, Cv, Gennari, S, Parini, S, Righini E (Azienda Unit&#224, Sanitaria Locale di Ferrara, - University of Ferrara), Ampollini, L, Bellanti, L, Bergonzani, M, Bertoli, G, Bocchialini, G, Angelo, G, Lanfranco, D, Musini, L, Poli, T, Santoro, Gp, Varazzani, A (Azienda Ospedaliero-Universitaria Di Parma), Aguzzoli, L, Borgonovo, G, Castro Ruiz, C, Coiro, S, Falco, G, Mandato, Vd, Mastrofilippo, V, Montella, Mt, Annessi, V, Zizzo M (Azienda Unit&#224, Sanitaria Locale, - Irccs Di Reggio Emilia), Grossi, U, Novello, S, Romano, M, Rossi, S, Zanus, G (Ca&#8217, Foncello Treviso-DISCOG-Universit Di Padova), Esposito, G, Frongia, F, Pisanu, A, Podda, M (Cagliari University Hospital), Belluco, C, Lauretta, A, Montori, G, Moras, L, Olivieri, M (Centro Di Riferimento Oncologico Di Aviano (Cro) Irccs), Bussu, F, Carta, Ag, Cossu, Ml, Cottu, P, Fancellu, A, Feo, Cf, Ginesu, Gc, Giuliani, G, Madonia, M, Perra, T, Piras, A, Porcu, A, Rizzo, D, Scanu, Am, Tedde, A, Tedde, M (Cliniche San Pietro, Sassari), A. o. u., Delrio, P, Rega D (Colorectal Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale-I. r. c. c. s., ), Badalamenti, G, Campisi, G, Cordova, A, Franza, M, Maniaci, G, Rinaldi, G, Toia, F (Department Of Surgical, University Of Palermo), Oncological And Oral Sciences., Calabr&#242, M, Farnesi, F, Lunghi, Eg, Muratore, A, Pipitone Federico NS (Edoardo Agnelli), B&#224, mbina, F, Andrea, G, Familiari, P, Picotti, V (Fabrizio Spaziani), De Palma, G, Luglio, G, Pagano, G, Tropeano FP (Federico Ii University Hospital), Baldari, L, Beltramini, Ga, Boni, L, Cassinotti, E, Gianni&#8217, Pignataro, L, Torretta S (Fondazione Irccs Ca&#8217, Granda, - Ospedale Maggiore Policlinico), Abatini, C, Baia, M, Biasoni, D, Bogani, G, Cadenelli, P, Capizzi, V, Cioffi, Spb, Citterio, D, Comini, Lv, Cosimelli, M, Fiore, M, Folli, S, Gennaro, M, Giannini, L, Gronchi, A, Guaglio, M, Macchi, A, Martinelli, F, Mazzaferro, V, Mosca, A, Pasquali, S, Piazza, C, Raspagliesi, F, Rolli, L, Salvioni, R, Sarpietro, G, Sarre, C, Sorrentino, L (Fondazione Irccs Istituto Nazionale Dei Tumori, Milano), Agnes, A, Alfieri, S, Belia, F, Biondi, A, Cozza, V, Amore, A, Ugo, D, De Simone, V, Fagotti, A, Gasparini, G, Gordini, L, Litta, F, Lombardi, Cp, Lorenzon, L, Marra, Aa, Marzi, F, Moro, A, Parello, A, Perrone, E, Persiani, R, Ratto, C, Rosa, F, Saponaro, G, Scambia, G, Scrima, O, Sganga, G, Tudisco, R (Fondazione Policlinico Universitario Agostino Gemelli), Belli, A, Granata, V, Izzo, F, Palaia, R, Patrone R (Hpb Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale- I. r. c. c. s., ), Carrano, Fm, Carvello, Mm, De Virgilio, A, Di Candido, F, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spinelli, A, Spriano, G (Humanitas Clinical And Research Center Irccs, Rozzano (Mi) &amp, Humanitas, University, Department Of Biomedical Sciences, Pieve Emanuele (Mi)), Donati, Dm, Frisoni, T, Palmerini, E (Irccs Istituto Ortopedico Rizzoli), Aprile, A, Barra, F, Batistotti, P, Ferrero, S, Fregatti, P, Scabini, S, Sparavigna, M (Irccs Ospedale Policlinico San Martino), Asti, E, Bernardi, D, Bonavina, L, Lovece, A (University of Milan, IRCCS Policlinico San Donato), Adamoli, L, Ansarin, M, Cenciarelli, S, Chu, F, De Berardinis, R, Fumagalli Romario, U, Mastrilli, F, Pietrobon, G, Tagliabue M (Istituto Europeo Di Oncologia, - Irccs -Milano), Badellino, E, Ferrero, A, Massobrio, R (Mauriziano Hospital Torino, Italy), De Manzoni Garberini, A (Ospedale Civile Spirito Santo), Federico, P, Maida, P, Marra, E, Marte, G, Petrillo, A, Tammaro, T, Tufo, A (Ospedale Del Mare), Berselli, M, Borroni, G, Cocozza, E, Conti, L, Desio, M, Livraghi, L, Quintodei, V, Rizzi, A, Zullo A (Ospedale Di Circolo, E Fondazione Macchi (Varese)), Baldi, C, Corbellini, C, Sampietro GM (Ospedale Di Rho, - Asst Rhodense), Cellerino P (Ospedale Fatebenefratelli, E Oftalmico), Baldini, E, Capelli, P, Isolani, Sm, Ribolla, M (Ospedale Guglielmo Da Saliceto Piacenza), Bondurri, A, Colombo, F, Ferrario, L, Guerci, C, Maffioli, A (Ospedale Luigi Sacco Milano), Armao, T, Ballabio, M, Bisagni, P, Gagliano, A, Longhi, M, Madonini, M, Pizzini, P (Ospedale Maggiore Di Lodi), Baietti, Am, Biasini, M, Maremonti, P, Neri, F, Prucher, Gm, Ricci, S, Ruggiero, F, Zarabini AG (Ospedale Maggiore/Bellaria Carlo Alberto Pizzardi Ausl Bologna), Barmasse, R, Mochet, S, Usai, A (Ospedale Regionale Umberto Parini), Leonardo - Asl Napoli 3 Sud, Incollingo P (Ospedale S., Castellammare Di Stabia), Mancini, S, Marino Cosentino, L, Sagnotta, A (Ospedale San Filippo Neri), Fruscio, R, Grassi, T, Nespoli, Lc, Tamini, N (Ospedale San Gerardo), Anastasi, A, Bartalucci, B, Bellacci, A, Canonico, G, Capezzuoli, L, Di Martino, C, Ipponi, P, Linari, C, Montelatici, M, Nelli, T, Spagni, G, Tirloni, L, Vitali, A (Ospedale San Giovanni Di Dio), Abate, E, Casati, M, Casiraghi, T, Laface, L, Schiavo M (Ospedale Vittorio Emanuele Iii, - Carate Brianza), Arminio, A, Cotoia, A, Lizzi, V, Vovola, F (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia), Vergari, R (Ospedali Riuniti Di Ancona), Ugo, S, Depalma, N, 8220, Vito Fazzi&#8221, Spampinato MG (P. o., Bartolucci, P, Brachini, G, Bruzzaniti, P, Chiappini, A, Chiarella, V, Ciccarone, F, Cicerchia, Pm, Cirillo, B, De Toma, G, Di bartolomeo, A, Fiori, E, Fonsi, Gb, Franco, G, Frati, A, Giugliano, M, Iannone, I, La Torre, F, Lapolla, P, Leonardo, C, Marruzzo, G, Meneghini, S, Mingoli, A, Ribuffo, D, Salvati, M, Santoro, A, Sapienza, P, Scafa, Ak, Simonelli, L, Zambon M (Policlinico Umberto, I Sapienza University Of Rome), Capolupo, Gt, Carannante, F, Caricato, M, Mascian&#224, G, Mazzotta, E (Policlinico Universitario Campus Bio Medico Of Rome), Gattolin, A, Migliore, M, Rimonda, R, Sasia, D, Travaglio, E (Regina Montis Regalis Hospital, Mondov&#236, Cervellera, M, Gori, A, Sartarelli, L, orsola-Malpighi Hospital), Tonini V (S., Giacometti, M, Zonta, S (Ospedale San Biagio, Asl, VCO), Chessa, A, Fiorini, A, Norcini, C (San Giovanni Di Dio), Colletti, G, Confalonieri, M, Costanzi, A, Frattaruolo, C, Mari, G, Monteleone, M (San Leopoldo Mandic), Bandiera, A, Bocciolone, L, Bonavina, G, Candiani, M, De Nardi, P, Gagliardi, F, Medone, M, Mortini, P, Negri, G, Ottolina, J, Parise, P, Piloni, M, Sileri, P, Vignali, A (San Raffaele Scientific Institute, Milan), Belvedere, A, Bernante, P, Bertoglio, P, Boussedra, S, Brunocilla, E, Cipriani, R, Cisternino, G, De Crescenzo, E, De Iaco, P, Dondi, G, Frio, F, Jovine, E, Mineo Bianchi, F, Neri, J, Parlanti, D, Perrone, Am, Pezzuto, Ap, Pignatti, M, Pinto, V, Poggioli, G, Ravaioli, M, Rottoli, M, Schiavina, R, Serenari, M, Serra, M, Solli, P, Taffurelli, M, Tanzanu, M, Tesei, M, Violante, T, Zanotti, S (Sant&#8217, orsola Hospital, Alma Mater Studiorum University Of Bologna, Borghi, F, Cianflocca, D, Di Maria Grimaldi, S, Donati, D, Gelarda, E, Geretto, P, Giraudo, G, Giuffrida, Mc, Marano, A, Palagi, S, Pellegrino, L, Peluso, C, Testa V (Santa Croce, E Carle Hospital, Cuneo), Agresta, F, Prando, D, Zese M (Santa Maria Degli Angeli Hospital Ulss5, - Adria), Aquila, F, Gambacciani, C, Lippa, L, Pieri, F, Santonocito OS (Spedali Riuniti Di Livorno), Armatura, G, Bertelli, G, Frena, A, Marinello, P, Notte, F, Patauner, S, Moritz Hospital), Scotton G (St., Fulginiti, Sf, Gallo, G, Sammarco, G, Vescio, G (University &#8216, Magna Graecia&#8217, Of Catanzaro), Balercia, P, Catarzi, L, Consorti G (University Hospital Umberto, I Ancona), Di Marzo, F (Valtiberina), Japan: Daiko H, Fontana T (Vittorio Emanuele)., Ishikawa, M, Ishiyama, K, Iwata, S, Kanematsu, K, Kanemitsu, Y, Kato, T, Kawai, A, Kobayashi, E, Kobayashi Kato, M, Moritani, K, Nakatani, F, Oguma, J, Tanase, Y, Jordan: Al Abdallah M, Uno M (National Cancer Center Hospital)., Ayasra, F, Ayasra, Y, Qasem, A (Al-Basheer Hospital), Abu Za&#8217, nouneh FJ, Fahmawee, T, Hmedat, A, Ibrahim, A, Obeidat, K (King Abdullah University Hospital), Abdel Al, S, Abdel Jalil, R, Abou Chaar MK, Al-Masri, M, Al-Najjar, H, Alawneh, F, Alsaraireh, O, Elayyan, M, Ghanem, R, Libya: Alkadeeki G (Al-Jalaa Hospital), Lataifeh I (King Hussein Cancer Center)., Aldokali, N, Senossi, O, Subhi MT (Alkhadra Hospital), Burgan, D, Kamoka, E, Kilani, Ai, Salamah, A, Salem, M, Shuwayyah, A (National Cancer Institute, Sabratha, - Libya), Abdulwahed, E, Alshareea, E, Aribi, N, Aribi, S, Biala, M, Ghamgh, R, Morgom, M (Tripoli Central Hospital), Aldayri, Z, Ellojli, I, Lithuania: Bradulskis S, Kredan A (Tripoli University Hospital)., Dainius, E, Kubiliute, E, Kutkevi&#269, ius, J, Parseliunas, A, Subocius, A, Madagascar: Rasoaherinomenjanahary F, Venskutonis D (Lithuanian University Of Health Sciences Kaunas Clinical Hospital)., Razafindrahita, Jb, Malaysia: Ong EC (Bintulu), Samison LH (Joseph Ravoahangy Andrianavalona Hospital)., Hamdan, Kh, Ibrahim, Mr, Tan, Ja, Thanapal MR (Hospital Kuala Lumpur), Amin Sahid, N, Hayati, F, Jayasilan, J, Sriram, Rk, Subramaniam, S (Queen Elizabeth Hospital &amp, Universiti Malaysia Sabah, Kota, Kinabalu, Sabah, Malaysia), Che Jusoh, A, Hussain, Ah, Mohamed Sidek AS, Mohd Yunus MF, Soh, Jy, Wong, Mpk, Zakaria, Ad, Zakaria, Z (School Of Medical Sciences &amp, Hospital, Universiti Sains Malaysia), Fadzli, A, Fathi, Nq, Koh, Ps, Liew, Yt, Roslani, Ac, Tang, Cy, Teoh, Ly, Wong, Wj, Mexico: Alvarez MR, Yahaya AS (University Malaya Medical Centre)., Arrangoiz, R, Cordera, F, De la Rosa Abaroa MA, G&#243, mez-Pedraza, A, Hernandez, R, Maffuz-Aziz, A, Posada JA (Abc Medical Center), Becerra Garc&#237, a FC (Hospital San &#193, ngel Inn Chapultepec), Alfaro-Goldaracena, A, Buerba, Ga, Castillejos- Molina RA, Chan, C, Dominguez-Rosado, I, Medina-Franco, H, Mercado, M&#225, Oropeza- Aguilar, M, Pe&#241, a G&#243, mez Portugal, E, Posadas-Trujillo, Oe, Rodriguez-Covarrubias, F, Salgado-Nesme, N, Morocco: Arkha Y, Vilatoba M (Instituto Nacional De Ciencias M&#233, dicas Y Nutrici&#243, n &#8220, Salvador Zubir&#225, n&#8221, Bechri, H, El Ouahabi, A, Oudrhiri MY (Centre Hospitalier Universitaire Ibn Sina Rabat), Derkaoui hassani F, El abbadi N (Cheikh Zaid International University Hospital), Amrani, L, Belkhadir, Zh, Benkabbou, A, Chakib, O, El Ahmadi, B, El Bouazizi, Y, Essangri, H, Ghannam, A, Majbar, Am, Mohsine, R, Netherlands: Hompes R, Souadka A (Institut National D&#8217, oncologie)., Meima-van Praag, E, Pronk, Ajm, Sharabiany, S (Amsterdam Umc, University Of Amsterdam), Grotenhuis, B, Hartveld, L, Reijers, S, Van Houdt, W (Antoni Van Leeuwenhoek Ziekenhuis), Baaij, J, Bolster-van Eenennaam, M, De Graaff, M, Sloothaak, D, Van Duijvendijk, P (Gelre Ziekenhuis), Posma-Bouman, L (Slingeland Ziekenhuis), Derksen, T, Franken, J, Oosterling, S (Spaarne Gasthuis), De Bree, R (University Medical Center Utrecht), Konsten, J, Nigeria: Fidelis L, Van Heinsbergen M (Viecuri Medisch Centrum)., Sholadoye, Tt, Tolani, M (Ahmadu Bello University Teaching Hospital), Olaogun, J (Ekiti State University Teaching Hospital), Egbuchulem, Ik, Lawal, Ta, Ogundoyin, O, Olulana DI (University College Hospital), Abdur-Rahman, L, Adeyeye, A, Aremu, I, Bello, J, Olasehinde, O, Oman: Massoud J, Popoola A (University Of Ilorin Teaching Hospital)., Massoud, R, Pakistan: Jamal A, Sorour TM (Khoula Hospital)., Kerawala AA (Cancer Foundation Hospital), Memon, As, Nafees Ahmed, R, Pfau Civil Hospital), Rai L (Dr Ruth K. m., Ayub, B, Hassan, N, Martins, Rs, Ramesh, P, Sayyed, R (Patel Hospital), Butt, U, Kashif, M, Khan, Wh, Qureshi, A, Umar, M, Waris Farooka, M, Wasim, T (Services Hospital Lahore), Ayubi, A, Rashid, I, Peru: Falcon GM, Waqar SH (The Pakistan Institute Of Medical Sciences)., Philippines: Jocson R, Robles R (Instituto Regional De Enfermedades Neopl&#225, sicas Del Sur)., Teh, C (National Kidney &amp, Poland: Major P (Jagiellonian University Medical College), Transplant Institute)., Bobi&#324, ski, M, Kotarski, J, Rasoul-Peli&#324, ska, K (Medical University Of Lublin, Portugal: Azevedo C, Chair And Department Of Gynaecological Oncology And Gynaecology)., Machado, D, Mendes, F (Centro Hospitalar Cova Da Beira), De Sousa, X (Centro Hospitalar De Set&#250, bal), Fernandes, U, Ferreira, C, Guidi, G, Leal, C, Mar&#231, al, A, Marques, R, Martins, D, Melo, A, Tenreiro, N, Vaz Pereira, R, Vieira B (Centro Hospitalar De Tr&#225, s-Os-Montes, E Alto Douro, E. p. e., ), Almeida, Ji, Correia de S&#225, T, Costa, Mjma, Fernandes, V, Ferraz, I, Gil, Cg, Lima da Silva, C, Lopes, L, Machado, N, Marialva, J, Nunes Coelho, M, Pedro, J, Pereira, C, Reis, R, Ribeiro, A, Santos, R, Saraiva, P, Silva, R, Tavares, F, Teixeira M (Centro Hospitalar Do Tamega, E Sousa), Almeida, Ac, Amaral, Mj, Andrade, R, Athayde Nem&#233, sio, R, Breda, D, Camacho, C, Canhoto, C, Colino, M, Correia, S, Costa, M, De Barros, J, De Oliveira L&#243, pez AL, Duque, M, Garrido, S, Guerreiro, P, Guimar&#227, es, A, L&#225, zaro, A, Lopes, C, Martins, R, Nogueira, O, Oliveira, A, Oliveira, Jm, Rodrigues, M, Ruivo, A, Santos, E, Silva, M, Sim&#245, es, J, Valente da Costa A (Centro Hospitalar, E Universit&#225, rio De Coimbra), Almeida, A, Cavaleiro, S, Devezas, V, Faria, Cs, J&#225, come, F, Magalh&#227, es Maia, M, Nogueiro, J, Pereira, A, Pereira-Neves, A, Pina-Vaz, T, Santos-Sousa, H, Silveira, H, Vaz, S, Vieira P (Centro Hospitalar, E Universit&#225, rio De S&#227, o Jo&#227, Gomes da Costa A, Lobo Antunes I (Centro Hospitalar Lisboa Norte), Pinto J, Tojal A (Centro Hospitalar Tondela-Viseu), Cardoso, N, Cardoso, P, Domingues, Jc, Henriques, P, Manso, Mi, Martins dos Santos, G, Morais, H, Pereira, R, Revez, T, Ribeiro, R, Ribeiro, Vi, Soares, A, Sousa, S, Teixeira J (Centro Hospitalar Universit&#225, rio Do Algarve, - Unidade De Faro), Amorim, E, Baptista, Vh, Cunha, Mf, Dias, B, Fazenda, A, Melo Neves JP, Policarpo, F, Sampaio da N&#243, voa Gomes Miguel II, Veiga D (Centro Hospitalar Universitario Do Algarve, - Unidade De Portim&#227, Andrade, Ak, Bandovas, Jp, Borges, N, Branquinho, A, Chumbinho, B, Correia, J, Fidalgo, H, Figueiredo de Barros, I, Frade, S, Gomes, J, Maciel, J, Pina, S, Rodrigues, A, Silva, N, Silveira Nunes, I, Sousa, R (Centro Hospitalar Universit&#225, rio Lisboa Central), Ascens&#227, o, J, Azevedo, P, Costeira, B, Cunha, C, Garrido, R, Gomes, H, Louren&#231, o, I, Mendinhos, G, Miranda, P, Nobre Pinto, A, Peralta Ferreira, M, Ribeiro, J, Rio Rodrigues, L, Sousa Fernandes, M (Hospital Beatriz Angelo), Azevedo J (Hospital Da Horta, E. p. e. ), Galv&#227, o, D, Soares, Ac, Vieira, A, Vieira, B (Hospital De Santo Espirito Da Ilha Terceira), Patr&#237, cio, B, Santos, Pmdd, Vieira Paiva Lopes AC (Hospital De Torres Vedras, - Centro Hospitalar Do Oeste), Cunha, R, Faustino, A, Freitas, A, Martins, Ab, Mendes, Jr, Parreira, R, Rosa, J, Teves, M (Hospital Do Divino Esp&#237, rito Santo), Abreu da Silva, A, Claro, M, Costa Santos, D, Deus, Ac, Grilo JV (Hospital Do Litoral Alentejano), Borges, F, Corte Real, J, Henriques, S, Lima, Mj, Matos Costa, P (Hospital Garcia De Orta), Brito da Silva, F, Caiado, A, Fonseca, F (Instituto Portugu&#234, s De Oncologia De Lisboa Francisco Gentil), 194, ngelo, M, Baiao, Jm, Martins Jord&#227, Vieira Caro&#231, o, T (Ipo Coimbra), Messias, J, Millan, A, Salgado, I, Santos, P (Ipo Lisboa), Ba&#237, a, C, Canotilho, R, Correia, Am, Ferreira Pinto AP, Peyroteo, M, Puerto Rico: Escobar P, Videira JF (Ipo Porto)., R&#233, union: Kassir R, Maldonado Santiago M (Instituto Gineco Oncologico)., Romania: Bezede C, Sauvat F (Chu Reunion)., Chitul, A, Ciofic, E, Cristian, D, Grama, F (Coltea Clinical Hospital), Pirtea L, Secosan C (Emergency Clinical City Hospital), Bonci, E, Gata, V, Ion Chiricuta Institute Of Oncology), Titu S (Prof. Dr., Ginghina, O, Iordache, N, Russia: Garmanova T, Iosifescu RV (Saint John Emergency Hospital)., Kazachenko, E, Markaryan, D, Rodimov, S, Tsarkov, P, Tulina, I (Clinic Of Coloproctology And Minimally Invasive Surgery, Sechenov Medical State University), Litvina, Y, Provozina, A (Immanuel Kant Baltic Federal University, Regional Clinical Hospital), Agapov, M, Galliamov, E, Kakotkin, V, Kubyshkin, V, 1050, 1072, 1084, 1083, 1086, 1074, &#1040, (Moscow Research And Educational Center, Saudi Arabia: Alshahrani M, Lomonosov Moscow State University)., Alsharif, F, Eskander, M (Aseer Central Hospital), Al Raddadi, R, Majrashi, S, Mashat, A (East Jeddah General Hospital), Akeel, N, Alharthi, M, Aljiffry, M, Basendowah, M, Farsi, A, Ghunaim, M, Khoja, A, Maghrabi, A, Malibary, N, Nassif, M, Nawawi, A, Saleem, A, Samkari, A, Trabulsi, N (King Abdulaziz University Hospital), Al Awwad, S, Alghamdi, M, Alnumani, T, Nasser, M, Said bayazeed, A (King Fahad General Hospital), Alhefdhi, A, Almalik, O, Alomair, A, Alotaibi, N, Alresaini, F, Alsalamah, R, Alsobhi, S, Mahasin, Z, Othman, E, Velagapudi, S (King Faisal Specialist Hospital), Al Habes, H, Alamri, A, Alkarak, S, Alqannas, M, Alyami, M, Alzamanan, M, Cort&#233, s Guiral, D, Elawad, A (King Khalid Hospital), AlAamer, O, Alriyees, L, Alselaim, N (King Saud Bin Abdulaziz University For Health Sciences, King Abdullah International Medical Research Center, Ministry Of National Guard, Health, Affairs, General Surgery Department., ), Abdulkareem, A, Ajlan, A, Akkour, K, Al-Habib, A, Al-Khayal, K, Alatar, A, Alburakan, A, Alhalal, H, Alhassan, B, Alhassan, N, Alobeed, O, Alsaif, A, Alsaif, F, Alshammari, S, Alshaygy, I, Barry, M, Bin Nasser, A, Bin Traiki, T, Bokhari, A, Elwatidy, S, Helmi, H, Madkhali, A, Nouh, T, Rabah, Pd, Serbia: Paunovic I, Zubaidi A (King Saud University)., Slijepcevic, N (Centre For Endocrine Surgery, Clinical Centre Of Serbia), Aleksi&#263, L, Antic, A, Barisic, G, Ceranic, M, Galun, D, Gruba&#269, &#381, Jelenkovic, J, Kecmanovi&#263, Kmezi&#263, Knezevic, D, Krivokapic, Z, Latin&#269, Markovic, V, Mati&#263, Miladinov, M, Pavlov, M, Pejovic, I, Radenkovic, D, Tadic, B, Vasljevi&#263, J, Velickovic, D, Zivanovic, M (Clinic For Digestive Surgery, Perovic M, Srbinovic L (Clinic For Gynecology And Obstetrics Narodni Front), Andrijasevic, S, Bozanovic, T, Cerovic Popovic, R, Dokic, M, Janjic, T, Jeremic, K, Kadija, S, Ladjevic Likic, I, Mirkovic, L, Pantovic, S, Pilic, I, Radojevic, M, Stefanovic, A, Vidakovic, S, Vilendecic, Z (Clinic For Gynecology And Obstetrics, Clinical Center Of Serbia), Antic, S, Dun&#273, erovi&#263, Jelovac, D, Jezdic, Z, Konstantinovic, V, Kotlar, B, Kuzmanovic, C, Lazi&#263, Petrovic, M, Popovic, F, Pucar, A, Romic, M, Sumrak, S, Vujanac, V (Clinic For Maxillofacial Surgery, School Of Dental Medicine, University Of Belgrade), Bascarevic, V, Bogdanovi&#263, I, Gruji&#269, Ilic, R, Mili&#263, evi&#263, Milisavljevi&#263, F, Miljkovi&#263, Paunovic, A, 352, 263, epanovi&#263, V, Stanimirovic, A, Todorovic, M (Clinic For Neurosurgery, Jotic, A, Milovanovic, J, Trivic, A (Clinic For Otorhinolaryngology And Maxillofacial Surgery, Bumbasirevic, U, Dzamic, Z, Kajmakovi&#263, B, Prijovi&#263, N, Zivkovic, M (Clinic Of Urology, Buta, M, Cvetkovic, A, Djurisic, I, Gacic, S, Goran, M, Inic, Z, Jeftic, N, Jevric, M, Jokic, V, Markovic, I, Milanovi&#263, Nikolic, S, Pejnovic, L, Savkovi&#263, Spurnic, I, Stevic, D, Stojiljkovic, D, Vucic, N, Zegarac, M (Institute For Oncology And Radiology Of Serbia), Karamarkovic, A, Kenic, M, Kovacevic, B, Krdzic, I, Singapore: Chan CW, Milutinovi&#263, V (Zvezdara University Medical Center)., Slovakia: G&#225, lis B, Lieske B (National University Hospital)., South Africa: Almgla N, &#352, imko K (University Hospital Bratislava)., Bernon, M, Boutall, A, Cairncross, L, Herman, A, Hilton, T, Jonas, E, Kloppers, C, Malherbe, F, Mugla, W, Nel, D, Rayamajhi, S, Van Wyngaard, T, Spain: Casta&#241, o-Leon AM, Vogel J (Groote Schuur Hospital)., Delgado Fernandez, J, Eiriz Fernandez, C, Espino Segura-Illa, M, Esteban Sinovas, O, Garcia Perez, D, Gomez, P, Jimenez-Roldan, L, Lagares, A, Moreno- Gomez, L, Paredes, I, P&#233, rez N&#250, 241, ez, A, S&#225, nchez Aniceto, G, Santas, M (12 De Octubre University Hospital), Fern&#225, ndez Rodr&#237, guez, P, Paniagua Garc&#237, a Se&#241, orans, M, Sanchez- Santos, R, Vigorita, V (&#193, lvaro Cunqueiro Hospital), Acrich, E, Baena Sanfeliu, E, Barrios, O, Golda, T, Santanach, C, Serrano-Navidad, M, Sorribas Grifell, M, Vives RV (Bellvitge University Hospital), Escol&#224, D, Jim&#233, nez A (Comarcal Alt Pened&#233, Cayetano Paniagua L, G&#243, mez Fern&#225, ndez L (Consorci Sanitari De Terrassa), Artigues, E, Bernal-Sprekelsen, Jc, Catal&#225, Bauset JC (Consorcio Hospital General Universitario), Collera, P, Diaz Del Gobbo, R, Farre Font, R, Flores Clotet, R, mez D&#237, az CJ, Gu&#224, rdia, N, Guariglia, Ca, Osorio, A, Sanchez Jimenez, R, Sanchon, L, Soto Montesinos C (Fundaci&#243, Althaia, - Xarxa Assistencial Universit&#224, ria De Manresa), Albi Martin B, Garc&#237, a Villayz&#225, n JE (Fundaci&#243, n Jimenez Diaz University Hospital), Alonso-Lamberti, L, Assaf, M, Baeza Pintado, N, Carabias, A, a-Quijada, J, Huertas Fernandez MA, Jimenez Miram&#243, n, J, Jimenez, V, Jover, Jm, Landeo Ag&#252, ero SA, Leon, R, Mart&#237, n Salamanca MB, rez Sim&#243, n, V, Ponce, S, Rodriguez, Jl, Salazar, A, Valle Rubio, A (Getafe University Hospital), Aguado, H (Hell&#237, n Hospital), Aldecoa Ansorregui, I, Bravo Infante, R, De Lacy FB, Di Somma, A, D&#237, az-Feijoo, B, Ense&#241, at Nora, J, Fabregas, N, Ferr&#233, s, A, Gil Iba&#241, ez, B, Gonzalez Sanchez JJ, Gracia, I, Hoyos Castro JA, Lacy, Am, Langdon, C, Mombl&#225, n, D, Morales, X, Oleaga, L, Otero, A, Pedrosa, L, Poblete Carrizo, J, Reyes Figueroa LA, Roldan Ramos, P, Rumia-Arboix, J, Tercero-Uribe, Ai, Topczewski, Te, Torales, J, Torne, A, Torn&#233, R, Turrado-Rodriguez, V, Valero, R, Valverde, S (Hospital Clinic Barcelona), Anula, R, Cano-Valderrama, O, Del Campo Mart&#237, n, M, ez-Valladares, L, Dom&#237, nguez, I, Dziakova, J, a Alonso, M, a Romero, E, mez Latorre, L, Muguerza, Jm, Pizarro, Mj, Saez Carlin, P, nchez del Pueblo, C, nchez-Pernaute, A, Sanz Ortega, G, Sanz-Lopez, R, Torres, A (Hospital Cl&#237, nico De Madrid), Garc&#233, s-Albir, M, Lopez, F, n-Ar&#233, valo, J, Moro-Valdezate, D, Pla-Marti, V (Hospital Cl&#237, nico Universitario De Valencia), Beltr&#225, n de Heredia, J, De Andr&#233, s Asenjo, B, mez Sanz, T, Jezieniecki, C, Nu&#241, ez Del Barrio, H, Ortiz de Sol&#243, rzano Aurusa FJ, Romero de Diego, A, Ruiz Soriano, M, Trujillo D&#237, az, J, Vazquez fernandez, A (Hospital Cl&#237, nico Universitario De Valladolid), Lora-Cumplido P, Sosa MV (Hospital De Cabue&#241, es), Gonzalez-Gonzalez E, Minaya Bravo AM (Hospital Del Henares), Alonso de la Fuente, N, Cazador Labat, M, Cecchini, L, Espinosa, Ca, Jimenez Toscano, M, L&#243, pez Campillo, A, Mancebo, G, Martorell, P, Munarriz, M (Hospital Del Mar), Grau-Talens EJ, Martin-Perez B (Hospital Don Benito-Villanueva), Benavides Buleje JA, Carrasco Prats, M, ndez, Pv, ndez-L&#243, pez, A, a Escudero, D, a Porcel VJ, Garcia Soria, V, Gim&#233, nez Franc&#233, s, C, Gonz&#225, lez Valverde FM, Gurrea, E, pez-Morales, P, Marco Garrido, A, nez Alonso JA, Medina, E, Mu&#241, oz Camarena JM, Parra Ba&#241, os PA, a Ros, E, Ramirez Faraco, M, Ruiz-Mar&#237, Sanchez Rodriguez, C, Valero Soriano, M (Hospital General Reina Sof&#237, Estaire G&#243, mez, M, ndez Camu&#241, as, &#193, Garcia Santos EP, Jimenez Higuera, E, nez-Pinedo, C, oz-Atienza, V, Padilla-Valverde, D, Pic&#243, n Rodr&#237, guez, R, Redondo Calvo FJ, nchez-Garc&#237, a, S, Sanchez-Pelaez, D (Hospital General Universitario De Ciudad Real), Colombari, Rc, Del valle, E, ndez, M, Lozano Lominchar, P, n, L, Rey Valcarcel, C, Steiner, Ma, Tudela, M, Zorrilla Ort&#250, zar, J (Hospital General Universitario Gregorio Mara&#241, 243, Alcaide Matas, F, a P&#233, rez JM, Troncoso Pereira, P (Hospital Mateu Orfila), Mora-Guzm&#225, n, I (Hospital Santa B&#225, rbara), Abell&#225, Achalandabaso Boira, M, Jorba, R, Memba Ikuga, R, Olona, C, Sales Mallafr&#233, R (Hospital Universitari De Tarragona Joan Xxiii), Cavall&#233, Busquets, P, Gavalda Pellice MGP, Salinas Pe&#241, a, J (Hospital Universitari Sant Joan), Aragon Achig EJ, Barbier, L, Caja Vivancos, P, Gainza, A, a Gutierrez JJ, Mallabiabarrena Ormaechea, G, Mar&#237, n, H, Martin Playa, P, Melchor Corc&#243, stegui, I, Prieto Calvo, M, Rodriguez Fraga, A, Villalabeitia Ateca, I (Hospital Universitario Cruces), De Andres Olabarria, U, Dur&#225, n Ballesteros, M, ndez Pablos FJ, Ib&#225, ez-Aguirre, Fj, Sanz Larrainzar, A, Ugarte-Sierra, B (Hospital Universitario De Galdakao), De la Hoz Rodr&#237, guez, &#193, Di Martino, M, a Septiem, J, Martin-Perez, E, oz de Nova JL (Hospital Universitario De La Princesa), Calvo Espino P, Guillamot Ruano P (Hospital Universitario De M&#243, stoles), Colao Garc&#237, a, L, az P&#233, rez, D, Esteban Agust&#237, E, Galindo Jara, P, Gutierrez Samaniego, M, Hernandez Bartolome MA, Serrano Gonz&#225, lez, J (Hospital Universitario De Torrej&#243, n De Ardoz), Alonso Poza, A, Di&#233, guez, B, a-Conde, M, Hern&#225, ndez-Garc&#237, a, M, Losada, M (Hospital Universitario Del Sureste), Chiesa-Estomba, Cm, lez Garc&#237, a J&#193, Larruscain, E, Sistiaga-Su&#225, rez JA (Hospital Universitario Donostia), Alvarez, E, Chavarrias, N, Fr&#237, as, L, a Pineda, V, Geg&#250, ndez Sim&#243, n, A, Gort&#225, zar, S, Gracia, M, Guevara, J, ndez Gutierrez, A, Loayza, A, a Dolores DT, C, Melendez, M, Moreno-Palacios, E, Perez, Y, Prieto Nieto MI, Ramos- Mart&#237, n, P, Rubio-Perez, I, Saavedra, J, Sanchez-Mendez, Ji, Siegrist Ridruejo, J, Urbieta, A, Zapardiel, I (Hospital Universitario La Paz), Cantalejo diaz, M, De Miguel Ardevines MDC, Duque-Mall&#233, Gascon Ferrer, I, lez-Nicol&#225, s Tr&#233, bol MT, Gracia-Roche, C, Herrero Lopez, M, Jariod Ferrer UM, Lanzon, A, Martinez German, A, Matute, M, Redondo, C, nchez Fuentes, N, nchez-Rubio, M, Santero-Ramirez, Ms, Saud&#237, Sim&#243, n Sanz MV, Uson-Bouthelier, T (Hospital Universitario Miguel Servet), Blazquez Martin, A, Diez Alonso, M, a Rico, E, Garcia-Loarte Gomez, E, Garcia-Moreno Nisa, F, Gutierrez Calvo, A, Hernandez, P, Lasa, I, Mendoza-Moreno, F, Morales Palacios, N, Ovejero Merino, E, Vera Mansilla, C (Hospital Universitario Principe De Asturias), Acebes Garc&#237, a, F, Bail&#243, Bueno Ca&#241, ones AD, Choolani Bhojwani, E, Marcos-Santos, P, Miguel, T, Pacheco S&#225, nchez, D, rez-Saborido, B, Sanchez Gonzalez, J, Tejero-Pintor FJ (Hospital Universitario R&#237, o Hortega), Alconchel, F, Conesa, A, Gil Mart&#237, nez, J, Guti&#233, rrez Fern&#225, ndez AI, Lopez Abad, A, Nicol&#225, s-L&#243, pez, T, Ramirez Romero, P, Roca Calvo MJ, Rodrigues, K, Ruiz Manzanera JJ, Soriano AI (Hospital Universitario Virgen De La Arrixaca), Cano, A, Capitan-Morales, L, Cintas Catena, J, Gomez-Rosado, J, Oliva Mompean, F, rez S&#225, nchez MA, R&#237, o Lafuente FD, Torres Arcos, C, Valdes-Hernandez, J (Hospital Universitario Virgen Macarena), Cholewa, H, Domingo, S, Frasson, M, Lago, V, Marina Martin, T, nez Chicote, C, Sancho-Muriel J (Hospital Universitario, Y Polit&#233, cnico La Fe), Landaluce-olavarria A, Lecumberri D (Hospital Urduliz), Abad Gurumeta, A, Abad-Motos, A, nez-Hurtado, E, Ripoll&#233, s-Melchor, J, Ruiz Escobar, A (Infanta Leonor University Hospital), Cuadrado- Garc&#237, a, A, Garcia-Sancho Tellez, L, Heras Aznar, J, Mat&#233, P, Ortega V&#225, zquez, I, Picardo, Al, Rojo L&#243, pez JA, Sanchez Cabezudo Noguera, F, Serralta de Colsa, D (Infanta Sof&#237, a University Hospital), Anchuelo Latorre, J, Cagigas Fernandez, C, Cai&#241, a Ruiz, R, Gomez Ruiz, M, Hernanz, F, Jimeno Fraile, J, nez-P&#233, rez, P, Poch, C, Santarrufina Martinez, S, Valbuena Jabares, V (Marqu&#233, s De Valdecilla University Hospital), Moliner-S&#225, nchez, C, Pingarron-Martin, L, Rey-Biel, J, Ruiz Martin, I (Rey Juan Carlos University Hospital), Blas Laina JL, Cros, B, Escartin, J, Garcia Egea, J, Nogu&#233, Talal El-Abur, I, Y&#225, nez, C (Royo Villanova), Cagigal Ortega EP, Cervera, I, az Pe&#241, a, P, Elena, Gdcr, Enjuto, D, ndez Bernab&#233, s Garc&#237, a, R, Gonzalez, J, ndez, I, Herrera-Merino, N, Marqueta De Salas, M, Martinez Pascual, P, Perez Gonzalez, M, Ramos Bonilla, A, Rodr&#237, guez G&#243, mez, L (Severo Ochoa University Hospital), Besc&#243, Blanco-Colino, R, Brana, I, Caimari, B, De Pablo Garc&#237, a-Cuenca, A, Duran-Valles, F, Espin-Basany, E, Giralt L&#243, pez de Sagredo, J, Pamias, J, Pellino, G, Prat, N, Pujol Pina, R, Sri Lanka: Arulanantham A, Saez barba M (Vall D&#8217, hebron University Hospital)., Bandara, Gbk, Jayarajah, U, Ravindrakumar, S, Rodrigo VS (District General Hospital Chilaw), Srishankar S (Teaching Hospital Anuradhapura). Sudan: Ali karar AA (Al-Rajhi). Sweden: Elbe P, Lindqvist EK (Karolinska University Hospital), Taflin, H (Sahlgrenska University Hospital), 196, lg&#229, Heinius, G, Nordberg, M, Pieniowski, E (South General Hospital), Gkekas, I, fgren, N, Ruteg&#229, rd, M, Switzerland: Arigoni M, Sund M (Umea University Hospital)., Bernasconi, M, Christoforidis, D, Di Giuseppe, M, La Regina, D, Mongelli, F (Ente Ospedaliero Cantonale), Chevallay, M, Dwidar, O, Gialamas, E, Sauvain, M (Hopital De Pourtales), Klenke, F, Koll&#224, r, A, Kurze, C (Inselspital, Bern University Hospital, University Of Bern), Adamina, M, B&#228, chler, T, Crugnale, As, Giardini, M, Guglielmetti, L, Peros, G, Turkey: Aghayeva A, Solimene F (Kantonsspital Winterthur)., Hamzaoglu, I, Sahin, I (Acibadem Altunizade Hospital), Akaydin, E, Aliyeva, Z, Aytac, E, Baca, B, D&#252, lgero&#287, lu, O, Ozben, V, Ozmen, Bb, Uras, C (Acibadem Atakent Hospital), Arikan, Ae, Bilgin, Ia, Bozk&#305, rl&#305, Ceyhan, Go, Kara, H, Karahasano&#287, lu, T, Uras, C (Acibadem Maslak Hospital), Celik, H (Adana Baskent University), Meydanli MM (Ankara City Hospital), Akilli, H, Ayhan, A, Kuscu, E (Baskent University), Onan MA (Gazi University Medical Faculty Hospital), Akgor, U, Dincer, Ha, Erol, T, Gultekin, M, Orhan, N, Ozgul, N, Salman, Mc, Soyak, B (Hacettepe University Hospital), Alhamed, A, Erg&#252, n, S, OZcel&#305, k, Mf, Sanli, An, Uluda&#287, Velidedeoglu, M, Zengin AK (Istanbul Universty, - Cerrahpa&#351, a Medical Faculty), Bozkurt, Ma, Kara, Y, Kocata&#351, A (Kanuni Sultan Suleyman Training And Research Hospital), Cimenoglu, B, Demirhan, R, Lutfi Kirdar Training And Research Hospital), Saracoglu K (Kartal Dr., Azamat, I&#775, f, Balik, E, Bu&#287, ra, D, Giray, B, Kulle, Cb, Taskiran, C, Vatansever, D (Ko&#231, University Medical School), G&#246, zal, K, G&#252, ler, Sa, ken, H, Tatar, Oc, Utkan, Nz, Y&#305, ld&#305, r&#305, m, A, Y&#252, ksel, E (Kocaeli University Teaching Hospital), Akin, E, Altintoprak, F, Bayhan, Z, Cakmak, G, 199, apo&#287, lu, R, elebi, F, Demir, H, Dikicier, E, Firat, N, n&#252, ll&#252, Kamburo&#287, lu, Mb, Kocer, B, 231, 252, k, If, Mantoglu, B (Sakarya University Faculty Of Medicine), olak, E, Kucuk, Go, Uyanik MS (Samsun Training And Research Hospital), 304, lhan Varank Training And Research Hospital), G&#246, ksoy B (Sehit Prof. dr., Bozkurt, E, Citgez, B, Mihmanli, M, Tanal, M, Yetkin, G (Sisli Hamidiye Etfal Training And Research Hospital), Akalin, M, Arican, C, Avci, Ek, Aydin, C, Demirli At&#305, c&#305, Emiroglu, M, Kaya, T, Kebab&#231, 305, Kilinc, G, Kirmizi, Y, 287, c&#252, H, Salimo&#287, lu, S, Sert, I&#775, Tugmen, C, Tuncer, K, Uslu, G, Ye&#351, ilyurt, D (University Of Health Sciences Tepecik Training And Research Hospital), Karaman, E, Kolusar&#305, A (Van Yuzuncu Yil University, Medical, Faculty), Uganda: Benson O, Yildiz A (Yildirim Beyazit University Yenimahalle Training And Research Hospital)., United Kingdom: Agilinko J, Lule H (Kampala International University Teaching Hospital)., Ahmeidat, A, Barabasz, M, Bekheit, M, Cheung, Lk, Colloc, T, Cymes, W, Elhusseini, M, Gradinariu, G, Hannah, A, Kamera, Bs, Mignot, G, Shaikh, S, Sharma, P (Aberdeen Royal Infirmary), Abu-Nayla, I, Agrawal, A, Al-Mohammad, A, Ali, S, Ashcroft, J, Azizi, A, Baker, O, Balakrishnan, A, Byrne, M, Colquhoun, A, Cotter, A, Coughlin, P, Davies, Rj, Durrani, A, Elshaer, M, Fordington, S, Forouhi, P, Georgiades, F, Grimes, H, Habeeb, A, Hudson, V, Hutchinson, P, Irune, E, Jah, A, Khan, Dz, Kolias, A, Kyriacou, H, Lamb, B, Liau, S, Luke, L, Mahmoud, R, Mannion, R, Masterson, L, Mitrofan, Cg, Mohan, M, Morris, A, Murphy, S, Neill, R, Price, S, Pushpa-rajah, J, Raby-Smith, W, Ramzi, J, Rooney, S, Santarius, T, Singh, A, Stewart, Gd, Tan, Xs, Townson, A, Tweedle, E, Walker, C, Waseem, S, Yordanov, S (Addenbrooke&#8217, Jones, T, Kattakayam, A, Loh, C, Lunevicius, R, Pringle, S, Schache, A, Shaw, R, Sheel, A (Aintree University Hospital), Rossborough, C (Altnagelvin Area Hospital), Angelou, D, Choynowski, M, McAree, B, McCanny, A, Neely, D (Antrim Area Hospital- Northern Health And Social Care Trust), Tutoveanu, G (Barnsley Hospital Nhs Foundation Trust), Ahad, S, De La Cruz Monroy MFI, Mosley, F, Oktseloglou, V (Bradford Royal Infirmary), Alanbuki, A, Patel, M, Shabana, A (Brighton And Sussex Nhs Trust, Princess Royal Hospital), Perera, E, Raveendran, D, Ravi- Shankar, K, Thiruchelvam, J (Broomfield Hospital), Arrowsmith L, Campbell W (Causeway Hospital), Grove, T, Kontovounisios, C, Warren, O (Chelsea And Westminster Hospital), Rolland, P (Cheltenham General Hospital), Aggarwal, A, Brown, S, Jelley, C, Neal, N (Churchill Hospital), Clifford, R, Eardley, N, Krishnan, E, Manu, N, Martin, E, Roy Mahapatra, S, Serevina, Ol, Smith, C, Vimalachandran, D (Countess Of Chester Hospital), Bordenave, M, Houston, R, Putnam, G, Robson, A, Tustin, H (Cumberland Infirmary), Emslie, K, Labib, Pl, Marchbank, A, Miller, D, Minto, G, Natale, J, Nwinee, H, Panahi, P, Rogers, L (Derriford Hospital), Abubakar, A, Akhter Rahman MM, Kyk, Ko, Brien, H, Sasapu, K, Woodun, H (Diana Princess Of Wales Hospital Grimsby), Inglis R, Ng HJ (Dumfries And Galloway Royal Infirmary), De Gea Rico, A, Ghazali, N, Lambert, J, Markose, G, Math, S, Sarantitis, I, Shrestha, D, Sultana, A, Taggarsi, M, Timbrell, S, Vaz, Op, Vitone, L (East Lancashire Hospitals Nhs Trust), Day, A, Dent, H, Fahim, M, Waheed, S (East Surrey Hospital), Hunt A, Laskar N (East Sussex Healthcare (Conquest Hospital And Eastbourne District General Hospital)), Gupta, A, Steinke, J, Thrumurthy, S (Epsom &amp, St Helier University Hospitals Nhs Trust), Massie, E, McGivern, K, Rutherford, D, Wilson, M (Forth Valley Royal Hospital), Hardie J, Kazzaz S (Frimley Health Nhs Ft - Frimley Park), Handa, S, Kaushal, M, Kler, A, Patel, P, Redfern, J, Tezas, S (Furness General Hospital), Aawsaj, Y, Amonkar, S, Blackwell, L, Blake, D, Carter, J, Emerson, H, Fisher, A, Katory, M, Korompelis, P, McCormick, W, Mustafa, A, Pearce, L, Ratnavelu, N, Reehal, R (Gateshead Health Nhs Foundation Trust), Kretzmer, L, Lalou, L, Manku, B, Parwaiz, I, Stafford, J (George Eliot Hospital), Abdelkarim, M, Asqalan, A, Gala, T, Ibrahim, S, Maw, A, Mithany, R, Morgan, R, Sundaram Venkatesan, G (Glan Clwyd Hospital), Ang, K, Caruana, Ej, Chowdhry, Mf, Mohammad, A, Nakas, A, Rathinam, S (Glenfield Hospital), Boal, M, Brown, O, Dwerryhouse, S, Higgs, S, Vallance, A (Gloucestershire Royal Hospital), Boyd, E, Irvine, V, Kirk, A (Golden Jubilee National Hospital), Bakolas, G, Boulton, A, Chandock, A, Khan, T, Kumar, M (Good Hope Hospital), Agoston, P, Bill&#232, Challacombe, B, Fraser, S, Harrison-Phipps, K, King, J, Mehra, G, Mills, L, Najdy, M, Nath, R, Okiror, L, Pilling, J, Rizzo, V, Routledge, T, Sayasneh, A, Stroman, L, Wali, A (Guy&#8217, Fehervari, M, Fotopoulou, C, Habib, N, Hamrang-Yousefi, S, Jawad, Z, Jiao, L, Pai, M, Ploski, J, Rajagopal, P, Saso, S, Sodergren, M, Spalding, D (Hammersmith Hospital), Laws, S (Hampshire Hospitals Nhs Trust), Hardie C, McNaught C (Harrogate District Hospital), Alam, R, Budacan, A, Cahill, J, Kalkat, M, Karandikar, S, Kenyon, L, Naumann, D, Patel, A (Heartlands Hospital), Ayorinde, J, Chase, T, Cuming, T, Ghanbari, A, Humphreys, L, Tayeh, S (Homerton University Hospital), Aboelkassem Ibrahim, A, Bichoo, R, Cao, H, Chai, Akw, Choudhury, J, Evans, C, Fitzjohn, H, Ikram, H, Langstroth, M, Loubani, M, McMillan, A, Nazir, S, Qadri, Ssa, Robinson, A, Ross, E, Sehgal, T, Wilkins, A (Hull University Teaching Hospitals Nhs Trust), Dixon, J, Dunning, J, Freystaetter, K, Jha, M, Lester, S, Madhavan, A, Thulasiraman, Sv, Viswanath, Y (James Cook University Hospital), Curl-Roper, T, Delimpalta, C, Liao, Ccl, Velchuru, V, Westwood, E (James Paget Univeristy Nhs Foundation Trust Hospital), Belcher, E, Bond-Smith, G, Chidambaram, S, Di Chiara, F, Fasanmade, K, Fraser, L, Fu, H, Ganau, M, Gore, S, Graystone, J, Jeyaretna, D, Khatkar, H, Lami, M, Maher, M, Mastoridis, S, Mihai, R, Piper, R, Prabhu, S, Risk, Obf, Selbong, U, Shah, K, Smillie, R, Soleymani majd, H, Sravanam, S, Stavroulias, D, Tebala, Gd, Vatish, M, Verberne, C, Wallwork, K, Winter, S (John Radcliffe Hospital), Bhatti, Mi, Boyd-Carson, H, Elsey, E, Gemmill, E, Herrod, P, Jibreel, M, Lenzi, E, Saafan, T, Sapre, D, Sian, T, Watson, N (King&#8217, s Mill Hospital), Athanasiou, A, Bourke, G, Bradshaw, L, Brunelli, A, Burke, J, Coe, P, Costigan, F, Elkadi, H, Ho, M, Johnstone, J, Kanatas, A, Kantola, V, Kaufmann, A, Laios, A, Lam, S, MacInnes, E, Munot, S, Nahm, C, Otify, M, Pompili, C, Smith, I, Theophilou, G, Toogood, G, Wade, R, Ward, D, West, C (Leeds Teaching Hospitals Trust), Annamalai, S, Ashmore, C, Boddy, A, Hossain, T, Kourdouli, A (Leicester Royal Infirmary), Gvaramadze, A, Jibril, A, Prusty, L, Thekkinkattil, D (Lincoln County Hospital), Harky A, Shackcloth M (Liverpool Heart And Chest Hospital), Askari, A, Cirocchi, N, Kudchadkar, S, Patel, K, Sagar, J, Shaw, S, Talwar, R (Luton And Dunstable University Hospital), Abdalla, M, Edmondson, R, Ismail, O, Jones, D, Newton, K, Stylianides, N (Manchester Royal Infirmary), Aderombi, A, Andaleeb, U, Bajomo, O, Beatson, K, Garrett, W, Mehmood, M, V (Medway Hospital), Ng, Al-Habsi, R, Divya, Gs, Keeler, B (Milton Keynes University Hospital), Al- Sarireh, B, Egan, R, Harries, R, Henry, A, Kittur, M, Li, Z, Parkins, K, Soliman, F, Spencer, N, Thompson, D (Morriston Hospital Swansea), Burgess, C, Gemmell, C, Grieco, C, Hollyman, M, Hunt, L, Morrison, J, Ojha, S, Ryan, N (Musgrove Park Hospital), Abbadessa, F, Barnard, S, Dawe, N, Hammond, J, Mahmoud Ali, F, McPherson, I, Mellor, C, Moir, J, Pandanaboyana, S, Powell, J, Rai, B, Roy, C, Sachdeva, A, Saleh, C, Tingle, S, Williams T (Newcastle Upon Tyne Hospitals Nhs Foundation Trust., ), Manickavasagam, J, McDonald, C, McGrath, N, McSorley, N, Ragupathy, K, Ramsay, L, Solth, A (Ninewells Hospital), Kakisi, O, Seebah, K, Shaikh, I, Sreedharan, L, Youssef, M (Norfolk And Norwich University Hospital), Shah, J (North Manchester General Hospital), Ameerally, P (Northampton General Hospital), McLarty, N, Mills, S, Shenfine, A (Northumbria Nhs Hospital Trust), Sahnan, K (Northwick Park Hospital), Abu, J, Addae-Boateng, E, Bratt, D, Brock, L, Burnside, N, Cadwell-Sneath, S, Gajjar, K, Gan, C, Grundy, C, Hallam, K, Hassell, K, Hawari, M, Joshi, A, Khout, H, Konstantinidi, K, Lee, Rxn, Nunns, D, Schiemer, R, Walton, T, Weaver, H, Whisker, L, Williamson, K (Nottingham City Hospital), McVeigh, J, Myatt, R, Williams MA (Nuffield Orthopaedic Centre), Kaur, R, Leung, E, Sundar, S (Pan- Birmingham Gynaecological Cancer Centre), Michel, M, Patil, S, Ravindran, S, Sarveswaran, J, Scott, L (Pinderfields Hospital), Edmond M, King E (Poole Hospital), Almond, M, Bhangu, A, Breik, O, Cato, Ld, Desai, A, Ford, S, Griffiths, E, Idle, M, Kamal, M, Kisiel, A, Kulkarni, R, Mak, Jkc, Martin, T, Nankivell, P, Parente, A, Parmar, S, Pathanki, Am, Phelan, L, Praveen, P, Saeed, S, Sharma, N, Singh, J, Tirotta, F, Vijayan, D (Queen Elizabeth Hospital Birmingham), Geddes, A, McCaul, J, McMahon, J (Queen Elizabeth University Hospital), Khan, Ah, Khan, F, Mansuri, A, Mukherjee, S, Sarigul, M, Singh, S, Tan, Kl, Woodham, A (Queen&#8217, s Hospital Romford), Adiamah, A, Brewer, H, Chowdhury, A, Evans, J, Humes, D, Jackman, J, Koh, A, Lewis-Lloyd, C, Oyende, O, Reilly, J, Worku, D (Queens Medical Centre), Cool, P, Cribb, G, Shepherd, K (Robert Jones And Agnes Hunt Orthopaedic Hospital), Bisset C, Moug S (Royal Alexandra Hospital), Elson, N, Faulkner, G, Saleh, P, Underwood, C (Royal Bolton Hospital), Brixton, G, Findlay, L, Klatte, T, Majkowska, A, Manson, J, Potter, R (Royal Bournemouth Hospital), Bhalla, A, Chia, Z, Daliya, P, Goyal, A, Grimley, E, Hamad, A, Kumar, A, Malcolm, Fl, Theophilidou, E (Royal Derby Hospital), Bowden, J, Campain, N, Daniels, I, Fowler, G, John, J, Massey, L, McDermott, F, McGrath, J, McLennan, A, Ng, M, Pascoe, J, Rajaretnam, N (Royal Devon And Exeter Hospital), Bulathsinhala, S, Davidson, B, Fusai, G, Hidalgo Salinas, C, Machairas, N, Pissanou, T, Pollok, Jm, Raptis, Da, Soggiu, F, Tzerbinis, H, Xyda SE (Royal Free Hospital), Beamish, A, Davies, E, Foulkes, R, Magowan, D, Nassa, H, Ooi, R, Price, C, Smith, L, Solari, F, Tang, A, Williams, G (Royal Gwent Hospital), Al-Tamimi, Y, Bacon, A, Beasley, N, Chew, D, Crank, M, Ilenkovan, N, Macdonald, M, Narice, B, Rominiyi, O, Thompson, A, Varley, I (Royal Hallamshire Hospital), Drake, T, Harrison, E, Linder, G, Mayes, J, McGregor, R, Skipworth, R, Zamvar, V (Royal Infirmary Of Edinburgh), Hawkin, P, Raymond, T, Ryska, O (Royal Lancaster Infirmary), Baron, R, Dunne, D, Gahunia, S, Halloran, C, Howes, N, McKinney, R, McNicol, F, Russ, J, Szatmary, P, Tan, Jr, Thomas, A, Whelan, P (Royal Liverpool University Hospital), Anzak, A, Banerjee, A, Fuwa, O, Hughes, F, Jayasinghe, Jd, Knowles, C, Kocher, H, Leal Silva, I, Ledesma, Fs, Minicozzi, A, Navaratne, L, Rahman, R, Ramamoorthy, R, Sohrabi, C, Thaha, M, Thakur, B, Venn, M, Yip, V (Royal London Hospital), Baumber R, Parry J (Royal National Orthopaedic Hospital), Evans, S, Jeys, L, Morris, G, Parry, M, Stevenson, J (Royal Orthopaedic Hospital), Ahmadi, N, Aresu, G, Barrett-Brown, Zm, Coonar, As, Durio Yates, H, Gearon, D, Hogan, J, King, M, Peryt, A, Pradeep, Is, Smith, C (Royal Papworth Hospital), Adishesh, M, Atherton, R, Baxter, K, Brocklehurst, M, Chaudhury, M, Krishnamohan, N, McAleer, J, Owens, G, Parkin, E, Patkar, P, Phang, I (Royal Preston Hospital), Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Thomas, M, Zakai, D (Royal Stoke University Hospital), Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, Madhuri, Tk, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D (Royal Surrey County Hospital), Aljanadi, F, Jones, M, Mhandu, P, Donnell, C, Turkington, R (Royal Victoria Hospital, Belfast), Al-Ishaq, Z, Bhasin, S, Bodla, As, Burahee, A, Crichton, A, Fossett, R, Pigadas, N, Rahman, E, Snee, D, Vidya, R, Yassin, N (Royal Wolverhampton Nhs Trust), Fountain, D, Hasan, Mt, Karabatsou, K, Laurente, R, Pathmanaban, O (Salford Royal Hospital), Al-mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E (Sheffield Teaching Hospital Nhs Foundation Trust), Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R (South Warwickshire Nhs Foundation Trust), Ethunandan, M, Sekhon, Gk, Shields, H, Singh, R, Wensley, F (Southampton General Hospital), Lawday S, Lyons A (Southmead Hospital), Abbott, T, Anwar, S, Ghufoor, K, Sohrabi, C (St Bartholomew&#8217, s Hospital (Non-Cardiac Unit)), Chung, E, Hagger, R, Hainsworth, A, Karim, A, Owen, H, Ramwell, A, Williams, K (St George&#8217, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W (St Thomas&#8217, Hospital), 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T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone Federico, N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De Palma, G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni, A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Cioffi, S. P. B., Citterio, D., Comini, L. V., Cosimelli, M., Folli, S., Gennaro, M., Giannini, L., Gronchi, A., Guaglio, M., Macchi, A., Martinelli, F., Mazzaferro, V., Mosca, A., Pasquali, S., Piazza, C., Raspagliesi, F., Rolli, L., Salvioni, R., Sarpietro, G., Sarre, C., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., D'Amore, A., D'Ugo, D., De Simone, V., Fagotti, A., Gasparini, G., Gordini, L., Litta, F., Lombardi, C. P., Lorenzon, L., Marra, A. A., Marzi, F., Moro, A., Parello, A., Perrone, E., Persiani, R., Ratto, C., Rosa, F., Saponaro, G., Scambia, G., Scrima, O., Sganga, G., Tudisco, R., Belli, A., Granata, V., Izzo, F., Palaia, R., Patrone, R., Carrano, F. M., Carvello, M. M., De Virgilio, A., Di Candido, F., Ferreli, F., Gaino, F., Mercante, G., Rossi, V., Spinelli, A., Spriano, G., Donati, D. M., Frisoni, T., Palmerini, E., Aprile, A., Barra, F., Batistotti, P., Ferrero, S., Fregatti, P., Scabini, S., Sparavigna, M., Asti, E., Bernardi, D., Bonavina, L., Lovece, A., Adamoli, L., Ansarin, M., Cenciarelli, S., Chu, F., De Berardinis, R., Fumagalli Romario, U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino Cosentino, L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., D'Ugo, S., Depalma, N., Spampinato, M. G., Bartolucci, P., Brachini, G., Bruzzaniti, P., Chiappini, A., Chiarella, V., Ciccarone, F., Cicerchia, P. M., Cirillo, B., De Toma, G., Di bartolomeo, A., Fiori, E., Fonsi, G. B., Franco, G., Frati, A., Giugliano, M., Iannone, I., La Torre, F., Lapolla, P., Leonardo, C., Marruzzo, G., Meneghini, S., Mingoli, A., Ribuffo, D., Salvati, M., Santoro, A., Sapienza, P., Scafa, A. K., Simonelli, L., Zambon, M., Capolupo, G. T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De Nardi, P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di Maria Grimaldi, S., Gelarda, E., Geretto, P., Giraudo, G., Giuffrida, M. C., Marano, A., Palagi, S., Pellegrino, L., Peluso, C., Testa, V., Agresta, F., Prando, D., Zese, M., Aquila, F., Gambacciani, C., Lippa, L., Pieri, F., Santonocito, O. S., Armatura, G., Bertelli, G., Frena, A., Marinello, P., Notte, F., Patauner, S., Scotton, G., Fulginiti, S. F., Gallo, G., Sammarco, G., Vescio, G., Balercia, P., Catarzi, L., Consorti, G., Di Marzo, F., Fontana, T., Daiko, H., Ishikawa, M., Ishiyama, K., Iwata, S., Kanematsu, K., Kanemitsu, Y., Kato, T., Kawai, A., Kobayashi, E., Kobayashi Kato, M., Moritani, K., Nakatani, F., Oguma, J., Tanase, Y., Uno, M., Al Abdallah, M., Ayasra, F., Ayasra, Y., Qasem, A., Abu Za'nouneh, F. J., Fahmawee, T., Hmedat, A., Ibrahim, A., Obeidat, K., Abdel Al, S., Abdel Jalil, R., Abou Chaar, M. K., Al-Masri, M., Al-Najjar, H., Alawneh, F., Alsaraireh, O., Elayyan, M., Ghanem, R., Lataifeh, I., Alkadeeki, G. Z., Al Maadany, F. S., Aldokali, N., Senossi, O., Subhi, M. T., Burgan, D., Kamoka, E., Kilani, A. I., Salamah, A., Salem, M., Shuwayyah, A., Abdulwahed, E., Alshareea, E., Aribi, N., Aribi, S., Biala, M., Ghamgh, R., Morgom, M., Aldayri, Z., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevicius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Ong, E. C., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin Sahid, N., Hayati, F., Jayasilan, J., Sriram, R. K., Subramaniam, S., Che Jusoh, A., Hussain, A. H., Mohamed Sidek, A. S., Mohd Yunus, M. F., Soh, J. Y., Wong, M. P. K., Zakaria, A. D., Zakaria, Z., Fadzli, A., Fathi, N. Q., Koh, P. S., Liew, Y. T., Roslani, A. C., Tang, C. Y., Teoh, L. Y., Wong, W. J., Yahaya, A. S., Alvarez, M. R., Arrangoiz, R., Cordera, F., De La Rosa Abaroa, M. A., Gomez-Pedraza, A., Hernandez, R., Maffuz-Aziz, A., Posada, J. A., Becerra Garcia, F. C., Alfaro-Goldaracena, A., Buerba, G. A., Castillejos-Molina, R. A., Chan, C., Dominguez-Rosado, I., Medina-Franco, H., Mercado, M. A., Oropeza-Aguilar, M., Pena Gomez Portugal, E., Posadas-Trujillo, O. E., Rodriguez-Covarrubias, F., Salgado-Nesme, N., Vilatoba, M., Arkha, Y., Bechri, H., El Ouahabi, A., Oudrhiri, M. Y., Derkaoui hassani, F., El Abbadi, N., Amrani, L., Belkhadir, Z. H., Benkabbou, A., Chakib, O., El Ahmadi, B., El Bouazizi, Y., Essangri, H., Ghannam, A., Majbar, A. M., Mohsine, R., Souadka, A., Hompes, R., Meima-Van Praag, E. M., Pronk, A. J. M., Sharabiany, S., Grotenhuis, B., Hartveld, L., Reijers, S., Van Houdt, W., Baaij, J., Bolster-Van Eenennaam, M., De Graaff, M., Sloothaak, D., Van Duijvendijk, P., Posma-Bouman, L., Derksen, T., Franken, J., Oosterling, S., De Bree, R., Konsten, J., Van Heinsbergen, M., Fidelis, L., Sholadoye, T. T., Tolani, M. A., Olaogun, J., Egbuchulem, I. K., Lawal, T. A., Ogundoyin, O., Olulana, D. I., Abdur-Rahman, L., Adeyeye, A., Aremu, I., Bello, J., Olasehinde, O., Popoola, A., Massoud, J., Massoud, R., Sorour, T. M., Jamal, A., Kerawala, A. A., Memon, A. S., Nafees Ahmed, R., Rai, L., Ayub, B., Hassan, N., Martins, R. S., Ramesh, P., Sayyed, R., Butt, U., Kashif, M., Khan, W. H., Qureshi, A., Umar, M., Waris Farooka, M., Wasim, T., Ayubi, A., Rashid, I., Waqar, S. H., Falcon, G. M., Robles, R., Jocson, R., Teh, C., Major, P., Bobinski, M., Kotarski, J., Rasoul-Pelinska, K., Azevedo, C., Machado, D., Mendes, F., De Sousa, X., Fernandes, U., Ferreira, C., Guidi, G., Leal, C., Marcal, A., Marques, R., Martins, D., Melo, A., Tenreiro, N., Vaz Pereira, R., Vieira, B., Almeida, J. I., Correia de Sa, T., Costa, M. J. M. A., Fernandes, V., Ferraz, I., Gil, C. G., Lima Da Silva, C., Lopes, L., Machado, N., Marialva, J., Nunes Coelho, M., Pedro, J., Pereira, C., Reis, R., Ribeiro, A., Santos, R., Saraiva, P., Silva, R., Tavares, F., Teixeira, M., Almeida, A. C., Amaral, M. J., Andrade, R., Athayde Nemesio, R., Breda, D., Camacho, C., Canhoto, C., Colino, M., Correia, S., De Barros, J., De Oliveira Lopez, A. L., Duque, M., Garrido, S., Guerreiro, P., Guimaraes, A., Lazaro, A., Lopes, C., Nogueira, O., Oliveira, A., Oliveira, J. M., Rodrigues, M., Ruivo, A., Santos, E., Silva, M., Simoes, J., Valente Da Costa, A., Almeida, A., Cavaleiro, S., Devezas, V., Faria, C. S., Jacome, F., Magalhaes Maia, M., Nogueiro, J., Pereira, A., Pereira-Neves, A., Pina-Vaz, T., Santos-Sousa, H., Silveira, H., Vaz, S., Vieira, P., Gomes Da Costa, A., Lobo Antunes, I., Pinto, J., Tojal, A., Cardoso, N., Cardoso, P., Domingues, J. C., Henriques, P., Manso, M. I., Martins Dos Santos, G., Morais, H., Pereira, R., Revez, T., Ribeiro, R., Ribeiro, V. I., Sousa, S., Teixeira, J., Amorim, E., Baptista, V. H., Cunha, M. F., Dias, B., Fazenda, A., Melo Neves, J. P., Policarpo, F., Sampaio Da Novoa Gomes Miguel, I. I., Veiga, D., Andrade, A. K., Bandovas, J. P., Borges, N., Branquinho, A., Chumbinho, B., Correia, J., Fidalgo, H., Figueiredo De Barros, I., Frade, S., Gomes, J., Maciel, J., Pina, S., Rodrigues, A., Silva, N., Silveira Nunes, I., Sousa, R., Ascensao, J., Azevedo, P., Costeira, B., Cunha, C., Garrido, R., Gomes, H., Lourenco, I., Mendinhos, G., Miranda, P., Nobre Pinto, A., Peralta Ferreira, M., Ribeiro, J., Rio Rodrigues, L., Sousa Fernandes, M., Azevedo, J., Galvao, D., Soares, A. C., Vieira, A., Patricio, B., Santos, P. M. D. D., Vieira Paiva Lopes, A. C., Cunha, R., Faustino, A., Freitas, A., Martins, A. B., Mendes, J. R., Parreira, R., Rosa, J., Teves, M., Abreu Da Silva, A., Claro, M., Costa Santos, D., Deus, A. C., Grilo, J. V., Borges, F., Corte Real, J., Henriques, S., Lima, M. J., Matos Costa, P., Brito da Silva, F., Caiado, A., Fonseca, F., Angelo, M., Baiao, J. M., Martins Jordao, D., Vieira Caroco, T., Messias, J., Millan, A., Salgado, I., Baia, C., Canotilho, R., Correia, A. M., Ferreira Pinto, A. P., Peyroteo, M., Videira, J. F., Escobar, P., Maldonado Santiago, M., Kassir, R., Sauvat, F., Bezede, C., Chitul, A., Ciofic, E., Cristian, D., Grama, F., Pirtea, L., Secosan, C., Bonci, E., Gata, V., Titu, S., Ginghina, O., Iordache, N., Iosifescu, R. V., Garmanova, T., Kazachenko, E., Markaryan, D., Rodimov, S., Tsarkov, P., Tulina, I., Litvina, Y., Provozina, A., Agapov, M., Galliamov, E., Kakotkin, V., Kubyshkin, V., Alshahrani, M., Alsharif, F., Eskander, M., Al Raddadi, R., Majrashi, S., Mashat, A., Akeel, N., Alharthi, M., Aljiffry, M., Basendowah, M., Farsi, A., Ghunaim, M., Khoja, A., Maghrabi, A., Malibary, N., Nassif, M., Nawawi, A., Saleem, A., Samkari, A., Trabulsi, N., Al Awwad, S., Alghamdi, M., Alnumani, T., Nasser, M., Said bayazeed, A., Alhefdhi, A., Almalik, O., Alomair, A., Alotaibi, N., Alresaini, F., Alsalamah, R., Alsobhi, S., Mahasin, Z., Othman, E., Velagapudi, S., Ghedan, S., Alharthi, R., Awad, S., Sharara, M., Abdelrahman, S., Althobaiti, W., Al Habes, H., Alamri, A., Alkarak, S., Alqannas, M., Alyami, M., Alzamanan, M., Cortes Guiral, D., Elawad, A., Alaamer, O., Alriyees, L., Alselaim, N., Abdulkareem, A., Ajlan, A., Akkour, K., Al-Habib, A., Al-Khayal, K., Alatar, A., Alburakan, A., Alhalal, H., Alhassan, B., Alhassan, N., Alobeed, O., Alsaif, A., Alsaif, F., Alshammari, S., Alshaygy, I., Barry, M., Bin Nasser, A., Bin Traiki, T., Bokhari, A., Elwatidy, S., Helmi, H., Madkhali, A., Nouh, T., Rabah, P. D., Zubaidi, A., Paunovic, I., Slijepcevic, N., Aleksic, L., Antic, A., Barisic, G., Ceranic, M., Galun, D., Grubac, Z., Jelenkovic, J., Kecmanovic, D., Kmezic, S., Knezevic, D., Krivokapic, Z., Latincic, S., Markovic, V., Matic, S., Miladinov, M., Pavlov, M., Pejovic, I., Radenkovic, D., Tadic, B., Vasljevic, J., Velickovic, D., Zivanovic, M., Perovic, M., Srbinovic, L., Andrijasevic, S., Bozanovic, T., Cerovic Popovic, R., Dokic, M., Janjic, T., Jeremic, K., Kadija, S., Ladjevic Likic, I., Mirkovic, L., Pantovic, S., Pilic, I., Radojevic, M., Stefanovic, A., Vidakovic, S., Vilendecic, Z., Antic, S., Dunderovic, D., Jelovac, D., Jezdic, Z., Konstantinovic, V., Kotlar, B., Kuzmanovic, C., Lazic, M., Petrovic, M., Popovic, F., Pucar, A., Romic, M., Sumrak, S., Vujanac, V., Bascarevic, V., Bogdanovic, I., Grujicic, D., Ilic, R., Milicevic, M., Milisavljevic, F., Miljkovic, A., Paunovic, A., Scepanovic, V., Stanimirovic, A., Todorovic, M., Jotic, A., Milovanovic, J., Trivic, A., Bumbasirevic, U., Dzamic, Z., Kajmakovic, B., Prijovic, N., Zivkovic, M., Buta, M., Cvetkovic, A., Djurisic, I., Gacic, S., Goran, M., Inic, Z., Jeftic, N., Jevric, M., Jokic, V., Markovic, I., Milanovic, M., Nikolic, S., Pejnovic, L., Savkovic, N., Spurnic, I., Stevic, D., Stojiljkovic, D., Vucic, N., Zegarac, M., Karamarkovic, A., Kenic, M., Kovacevic, B., Krdzic, I., Milutinovic, V., Lieske, B., Galis, B., Simko, K., Almgla, N., Bernon, M., Boutall, A., Cairncross, L., Herman, A., Hilton, T., Jonas, E., Kloppers, C., Malherbe, F., Mugla, W., Nel, D., Rayamajhi, S., Van Wyngaard, T., Vogel, J., Castano-Leon, A. M., Delgado Fernandez, J., Eiriz Fernandez, C., Espino Segura-Illa, M., Esteban Sinovas, O., Garcia Perez, D., Gomez, P., Jimenez-Roldan, L., Lagares, A., Moreno-Gomez, L., Paredes, I., Perez Nunez, A., Sanchez Aniceto, G., Santas, M., Fernandez Rodriguez, P., Paniagua Garcia Senorans, M., Sanchez-Santos, R., Vigorita, V., Acrich, E., Baena Sanfeliu, E., Barrios, O., Golda, T., Santanach, C., Serrano-Navidad, M., Sorribas Grifell, M., Vives, R. V., Escola, D., Jimenez, A., Cayetano Paniagua, L., Gomez Fernandez, L., Artigues, E., Bernal-Sprekelsen, J. C., Catala Bauset, J. C., Collera, P., Diaz Del Gobbo, R., Farre Font, R., Flores Clotet, R., Gomez Diaz, C. J., Guardia, N., Guariglia, C. A., Osorio, A., Sanchez Jimenez, R., Sanchon, L., Soto Montesinos, C., Albi Martin, B., Garcia Villayzan, J. E., Alonso-Lamberti, L., Assaf, M., Baeza Pintado, N., Carabias, A., Garcia-Quijada, J., Huertas Fernandez, M. A., Jimenez Miramon, J., Jimenez, V., Jover, J. M., Landeo Aguero, S. A., Leon, R., Martin Salamanca, M. B., Perez Simon, V., Ponce, S., Rodriguez, J. L., Salazar, A., Valle Rubio, A., Aguado, H., Aldecoa Ansorregui, I., Bravo Infante, R., De Lacy, F. B., Di Somma, A., Diaz-Feijoo, B., Ensenat Nora, J., Fabregas, N., Ferres, A., Gil Ibanez, B., Gonzalez Sanchez, J. J., Gracia, I., Hoyos Castro, J. A., Lacy, A. M., Langdon, C., Momblan, D., Morales, X., Oleaga, L., Otero, A., Pedrosa, L., Poblete Carrizo, J., Reyes Figueroa, L. A., Roldan Ramos, P., Rumia-Arboix, J., Tercero-Uribe, A. I., Topczewski, T. E., Torales, J., Torne, A., Torne, R., Turrado-Rodriguez, V., Valero, R., Valverde, S., Anula, R., Cano-Valderrama, O., Del Campo Martin, M., Diez-Valladares, L., Dominguez, I., Dziakova, J., Garcia Alonso, M., Garcia Romero, E., Gomez Latorre, L., Muguerza, J. M., Pizarro, M. J., Saez Carlin, P., Sanchez Del Pueblo, C., Sanchez-Pernaute, A., Sanz Ortega, G., Sanz-Lopez, R., Torres, A., Garces-Albir, M., Lopez, F., Martin-Arevalo, J., Moro-Valdezate, D., Pla-Marti, V., Beltran De Heredia, J., De Andres Asenjo, B., Gomez Sanz, T., Jezieniecki, C., Nunez Del Barrio, H., Ortiz De Solorzano Aurusa, F. J., Romero De Diego, A., Ruiz Soriano, M., Trujillo Diaz, J., Vazquez Fernandez, A., Lora-Cumplido, P., Sosa, M. V., Gonzalez-Gonzalez, E., Minaya Bravo, A. M., Alonso de la Fuente, N., Cazador Labat, M., Cecchini, L., Espinosa, C. A., Jimenez Toscano, M., Lopez Campillo, A., Mancebo, G., Martorell, P., Munarriz, M., Grau-Talens, E. J., Martin-Perez, B., Benavides Buleje, J. A., Carrasco Prats, M., Fernandez, P. V., Fernandez-Lopez, A., Garcia Escudero, D., Garcia Porcel, V. J., Garcia Soria, V., Gimenez Frances, C., Gonzalez Valverde, F. M., Gurrea, E., Lopez-Morales, P., Marco Garrido, A., Martinez Alonso, J. A., Medina, E., Munoz Camarena, J. M., Parra Banos, P. A., Pena Ros, E., Ramirez Faraco, M., Ruiz-Marin, M., Sanchez Rodriguez, C., Valero Soriano, M., Estaire Gomez, M., Fernandez Camunas, A., Garcia Santos, E. P., Jimenez Higuera, E., Martinez-Pinedo, C., Munoz-Atienza, V., Padilla-Valverde, D., Picon Rodriguez, R., Redondo Calvo, F. J., Sanchez-Garcia, S., Sanchez-Pelaez, D., Colombari, R. C., Del valle, E., Fernandez, M., Lozano Lominchar, P., Rey Valcarcel, C., Steiner, M. A., Tudela, M., Zorrilla Ortuzar, J., Alcaide Matas, F., Garcia Perez, J. M., Troncoso Pereira, P., Mora-Guzman, I., Abellan, M., Achalandabaso Boira, M., Jorba, R., Memba Ikuga, R., Olona, C., Sales Mallafre, R., Cavalle Busquets, P., Gavalda Pellice, M. G. P., Salinas Pena, J., Aragon Achig, E. J., Barbier, L., Caja Vivancos, P., Gainza, A., Garcia Gutierrez, J. J., Mallabiabarrena Ormaechea, G., Marin, H., Martin Playa, P., Melchor Corcostegui, I., Prieto Calvo, M., Rodriguez Fraga, A., Villalabeitia Ateca, I., De Andres Olabarria, U., Duran Ballesteros, M., Fernandez Pablos, F. J., Ibanez-Aguirre, F. J., Sanz Larrainzar, A., Ugarte-Sierra, B., De La Hoz Rodriguez, A., Di Martino, M., Garcia Septiem, J., Martin-Perez, E., Munoz De Nova, J. L., Calvo Espino, P., Guillamot Ruano, P., Colao Garcia, L., Diaz Perez, D., Esteban Agusti, E., Galindo Jara, P., Gutierrez Samaniego, M., Hernandez Bartolome, M. A., Serrano Gonzalez, J., Alonso Poza, A., Dieguez, B., Garcia-Conde, M., Hernandez-Garcia, M., Losada, M., Chiesa-Estomba, C. M., Gonzalez Garcia, J. A., Larruscain, E., Sistiaga-Suarez, J. A., Alvarez, E., Chavarrias, N., Frias, L., Garcia Pineda, V., Gegundez Simon, A., Gortazar, S., Gracia, M., Guevara, J., Hernandez Gutierrez, A., Loayza, A., Maria Dolores, D. T., Marti, C., Melendez, M., Moreno-Palacios, E., Perez, Y., Prieto Nieto, M. I., Ramos-Martin, P., Rubio-Perez, I., Saavedra, J., Sanchez-Mendez, J. I., Siegrist Ridruejo, J., Urbieta, A., Zapardiel, I., Cantalejo diaz, M., De Miguel Ardevines, M. D. C., Duque-Mallen, V., Gascon Ferrer, I., Gonzalez-Nicolas Trebol, M. T., Gracia-Roche, C., Herrero Lopez, M., Jariod Ferrer, U. M., Lanzon, A., Martinez German, A., Matute, M., Redondo, C., Sanchez Fuentes, N., Sanchez-Rubio, M., Santero-Ramirez, M. S., Saudi, S., Simon Sanz, M. V., Uson-Bouthelier, T., Blazquez Martin, A., Diez Alonso, M., Garcia Rico, E., Garcia-Loarte Gomez, E., Garcia-Moreno Nisa, F., Gutierrez Calvo, A., Hernandez, P., Lasa, I., Mendoza-Moreno, F., Morales Palacios, N., Ovejero Merino, E., Vera Mansilla, C., Acebes Garcia, F., Bailon, M., Bueno Canones, A. D., Choolani Bhojwani, E., Marcos-Santos, P., Miguel, T., Pacheco Sanchez, D., Perez-Saborido, B., Sanchez Gonzalez, J., Tejero-Pintor, F. J., Alconchel, F., Conesa, A., Gil Martinez, J., Gutierrez Fernandez, A. I., Lopez Abad, A., Nicolas-Lopez, T., Ramirez Romero, P., Roca Calvo, M. J., Rodrigues, K., Ruiz Manzanera, J. J., Soriano, A. I., Cano, A., Capitan-Morales, L., Cintas Catena, J., Gomez-Rosado, J., Oliva Mompean, F., Perez Sanchez, M. A., Rio Lafuente, F. D., Torres Arcos, C., Valdes-Hernandez, J., Cholewa, H., Domingo, S., Frasson, M., Lago, V., Marina Martin, T., Martinez Chicote, C., Sancho-Muriel, J., Landaluce-Olavarria, A., Lecumberri, D., Abad Gurumeta, A., Abad-Motos, A., Martinez-Hurtado, E., Ripolles-Melchor, J., Ruiz Escobar, A., Cuadrado-Garcia, A., Garcia-Sancho Tellez, L., Heras Aznar, J., Mate, P., Ortega Vazquez, I., Picardo, A. L., Rojo Lopez, J. A., Sanchez Cabezudo Noguera, F., Serralta De Colsa, D., Anchuelo Latorre, J., Cagigas Fernandez, C., Caina Ruiz, R., Gomez Ruiz, M., Hernanz, F., Jimeno Fraile, J., Martinez-Perez, P., Poch, C., Santarrufina Martinez, S., Valbuena Jabares, V., Moliner-Sanchez, C., Pingarron-Martin, L., Rey-Biel, J., Ruiz Martin, I., Blas Laina, J. L., Cros, B., Escartin, J., Garcia Egea, J., Nogues, A., Talal El-Abur, I., Yanez, C., Cagigal Ortega, E. P., Cervera, I., Diaz Pena, P., Elena, G. D. C. R., Enjuto, D., Fernandez Bernabe, P., Garces Garcia, R., Gonzalez, J., Hernandez, I., Herrera-Merino, N., Marqueta De Salas, M., Martinez Pascual, P., Perez Gonzalez, M., Ramos Bonilla, A., Rodriguez Gomez, L., Bescos, C., Blanco-Colino, R., Brana, I., Caimari, B., De Pablo Garcia-Cuenca, A., Duran-Valles, F., Espin-Basany, E., Giralt Lopez De Sagredo, J., Pamias, J., Pellino, G., Prat, N., Pujol Pina, R., Saez Barba, M., Arulanantham, A., Bandara, G. B. K., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S., Srishankar, S., Ali Karar, A. A., Elbe, P., Lindqvist, E. K., Taflin, H., Alga, A., Heinius, G., Nordberg, M., Pieniowski, E., Gkekas, I., Lofgren, N., Rutegard, M., Sund, M., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Klenke, F., Kollar, A., Kurze, C., Adamina, M., Bachler, T., Crugnale, A. S., Giardini, M., Guglielmetti, L., Peros, G., Solimene, F., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Dulgeroglu, O., Ozben, V., Ozmen, B. B., Uras, C., Arikan, A. E., Bilgin, I. A., Bozkirli, B., Ceyhan, G. O., Kara, H., Karahasanoglu, T., Celik, H., Meydanli, M. M., Akilli, H., Ayhan, A., Kuscu, E., Onan, M. A., Akgor, U., Dincer, H. A., Erol, T., Gultekin, M., Orhan, N., Ozgul, N., Salman, M. C., Soyak, B., Alhamed, A., Ergun, S., Ozcelik, M. F., Sanli, A. N., Uludag, S. S., Velidedeoglu, M., Zengin, A. K., Bozkurt, M. A., Kara, Y., Kocatas, A., Cimenoglu, B., Demirhan, R., Saracoglu, K., Azamat, I. F., Balik, E., Bugra, D., Giray, B., Kulle, C. B., Taskiran, C., Vatansever, D., Gozal, K., Guler, S. A., Koken, H., Tatar, O. C., Utkan, N. Z., Yildirim, A., Yuksel, E., Akin, E., Altintoprak, F., Bayhan, Z., Cakmak, G., Capoglu, R., Celebi, F., Demir, H., Dikicier, E., Firat, N., Gonullu, E., Kamburoglu, M. B., Kocer, B., Kucuk, I. F., Mantoglu, B., Colak, E., Kucuk, G. O., Uyanik, M. S., Goksoy, B., Bozkurt, E., Citgez, B., Mihmanli, M., Tanal, M., Yetkin, G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli Atici, S., Emiroglu, M., Kaya, T., Kebabci, E., Kilinc, G., Kirmizi, Y., Ogucu, H., Salimoglu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yesilyurt, D., Karaman, E., Kolusari, A., Yildiz, A., Benson, O., Lule, H., Agilinko, J., Ahmeidat, A., Barabasz, M., Bekheit, M., Cheung, L. K., Colloc, T., Cymes, W., Elhusseini, M., Gradinariu, G., Hannah, A., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Abu-Nayla, I., Agrawal, A., Al-Mohammad, A., Ali, S., Ashcroft, J., Azizi, A., Baker, O., Balakrishnan, A., Byrne, M., Colquhoun, A., Cotter, A., Coughlin, P., Davies, R. J., Durrani, A., Elshaer, M., Fordington, S., Forouhi, P., Georgiades, F., Grimes, H., Habeeb, A., Hudson, V., Hutchinson, P., Irune, E., Jah, A., Khan, D. Z., Kyriacou, H., Lamb, B., Liau, S., Luke, L., Mahmoud, R., Mannion, R., Masterson, L., Mitrofan, C. G., Mohan, M., Morris, A., Murphy, S., O'Neill, R., Price, S., Pushpa-Rajah, J., Raby-Smith, W., Ramzi, J., Rooney, S., Santarius, T., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Walker, C., Waseem, S., Yordanov, S., Jones, T., Kattakayam, A., Loh, C., Lunevicius, R., Pringle, S., Schache, A., Sheel, A., Rossborough, C., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Tutoveanu, G., Ahad, S., De La Cruz Monroy, M. F. I., Mosley, F., Oktseloglou, V., Alanbuki, A., Patel, M., Shabana, A., Perera, E., Raveendran, D., Ravi-Shankar, K., Thiruchelvam, J., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Rolland, P., Aggarwal, A., Brown, S., Jelley, C., Neal, N., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy Mahapatra, S., Serevina, O. L., Smith, C., Vimalachandran, D., Bordenave, M., Houston, R., Putnam, G., Robson, A., Tustin, H., Emslie, K., Labib, P. L., Marchbank, A., Miller, D., Minto, G., Natale, J., Nwinee, H., Panahi, P., Rogers, L., Abubakar, A., Akhter Rahman, M. M., Ko, K. Y. K., O'Brien, H., Sasapu, K., Woodun, H., Inglis, R., Ng, H. J., De Gea Rico, A., Ghazali, N., Lambert, J., Markose, G., Math, S., Sarantitis, I., Shrestha, D., Sultana, A., Taggarsi, M., Timbrell, S., Vaz, O. P., Vitone, L., Day, A., Dent, H., Fahim, M., Waheed, S., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Hardie, J., Kazzaz, S., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Amonkar, S., Blackwell, L., Blake, D., Carter, J., Emerson, H., Fisher, A., Katory, M., Korompelis, P., Mccormick, W., Mustafa, A., Pearce, L., Ratnavelu, N., Reehal, R., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram Venkatesan, G., Ang, K., Caruana, E. J., Chowdhry, M. F., Mohammad, A., Nakas, A., Rathinam, S., Boal, M., Brown, O., Dwerryhouse, S., Higgs, S., Vallance, A., Boyd, E., Irvine, V., Kirk, A., Bakolas, G., Boulton, A., Chandock, A., Khan, T., Kumar, M., Agoston, P., Bille, A., Challacombe, B., Fraser, S., Harrison-Phipps, K., King, J., Mehra, G., Mills, L., Najdy, M., Nath, R., Okiror, L., Pilling, J., Rizzo, V., Routledge, T., Sayasneh, A., Stroman, L., Wali, A., Fehervari, M., Fotopoulou, C., Habib, N., Hamrang-Yousefi, S., Jawad, Z., Jiao, L., Pai, M., Ploski, J., Rajagopal, P., Saso, S., Sodergren, M., Spalding, D., Laws, S., Hardie, C., Mcnaught, C., Alam, R., Budacan, A., Cahill, J., Kalkat, M., Karandikar, S., Kenyon, L., Naumann, D., Patel, A., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem Ibrahim, A., Bichoo, R., Cao, H., Chai, A. K. W., Choudhury, J., Evans, C., Fitzjohn, H., Ikram, H., Langstroth, M., Loubani, M., Mcmillan, A., Nazir, S., Qadri, S. S. A., Robinson, A., Ross, E., Sehgal, T., Wilkins, A., Dixon, J., Dunning, J., Freystaetter, K., Jha, M., Lester, S., Madhavan, A., Thulasiraman, S. V., Viswanath, Y., Curl-Roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Belcher, E., Bond-Smith, G., Chidambaram, S., Di Chiara, F., Fasanmade, K., Fraser, L., Fu, H., Ganau, M., Gore, S., Graystone, J., Jeyaretna, D., Khatkar, H., Lami, M., Maher, M., Mastoridis, S., Mihai, R., Piper, R., Prabhu, S., Risk, O. B. F., Selbong, U., Shah, K., Smillie, R., Soleymani majd, H., Sravanam, S., Stavroulias, D., Tebala, G. D., Vatish, M., Verberne, C., Wallwork, K., Winter, S., Bhatti, M. I., Boyd-Carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Bourke, G., Bradshaw, L., Brunelli, A., Burke, J., Coe, P., Costigan, F., Elkadi, H., Johnstone, J., Kanatas, A., Kantola, V., Kaufmann, A., Laios, A., Lam, S., Macinnes, E., Munot, S., Nahm, C., Otify, M., Pompili, C., Smith, I., Theophilou, G., Toogood, G., Wade, R., Ward, D., West, C., Annamalai, S., Ashmore, C., Boddy, A., Hossain, T., Kourdouli, A., Gvaramadze, A., Jibril, A., Prusty, L., Thekkinkattil, D., Harky, A., Shackcloth, M., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Shaw, S., Talwar, R., Abdalla, M., Edmondson, R., Ismail, O., Jones, D., Newton, K., Stylianides, N., Aderombi, A., Andaleeb, U., Bajomo, O., Beatson, K., Garrett, W., Mehmood, M., Ng, V., Al-Habsi, R., Divya, G. S., Keeler, B., Al-Sarireh, B., Egan, R., Harries, R., Henry, A., Kittur, M., Li, Z., Parkins, K., Soliman, F., Spencer, N., Thompson, D., Burgess, C., Gemmell, C., Grieco, C., Hollyman, M., Hunt, L., Morrison, J., Ojha, S., Ryan, N., Abbadessa, F., Barnard, S., Dawe, N., Hammond, J., Mahmoud Ali, F., Mcpherson, I., Mellor, C., Moir, J., Pandanaboyana, S., Powell, J., Rai, B., Roy, C., Sachdeva, A., Saleh, C., Tingle, S., Williams, T., Manickavasagam, J., Mcdonald, C., Mcgrath, N., Mcsorley, N., Ragupathy, K., Ramsay, L., Solth, A., Kakisi, O., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Ameerally, P., Mclarty, N., Mills, S., Shenfine, A., Sahnan, K., Abu, J., Addae-Boateng, E., Bratt, D., Brock, L., Burnside, N., Cadwell-Sneath, S., Gajjar, K., Gan, C., Grundy, C., Hallam, K., Hassell, K., Hawari, M., Joshi, A., Khout, H., Konstantinidi, K., Lee, R. X. N., Nunns, D., Schiemer, R., Walton, T., Weaver, H., Whisker, L., Williamson, K., Mcveigh, J., Myatt, R., Williams, M. A., Kaur, R., Leung, E., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Edmond, M., King, E., Almond, M., Breik, O., Cato, L. D., Idle, M., Kamal, M., Kisiel, A., Kulkarni, R., Mak, J. K. C., Martin, T., Nankivell, P., Parente, A., Parmar, S., Pathanki, A. M., Phelan, L., Praveen, P., Saeed, S., Sharma, N., Singh, J., Tirotta, F., Vijayan, D., Geddes, A., Mccaul, J., Mcmahon, J., Khan, A. H., Khan, F., Mansuri, A., Mukherjee, S., Sarigul, M., Singh, S., Tan, K. L., Woodham, A., Adiamah, A., Brewer, H., Chowdhury, A., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis-Lloyd, C., Oyende, O., Reilly, J., Worku, D., Cool, P., Cribb, G., Shepherd, K., Bisset, C., Moug, S., Elson, N., Faulkner, G., Saleh, P., Underwood, C., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Goyal, A., Grimley, E., Hamad, A., Kumar, A., Malcolm, F. L., Theophilidou, E., Bowden, J., Campain, N., Daniels, I., Fowler, G., John, J., Massey, L., Mcdermott, F., Mcgrath, J., Mclennan, A., Ng, M., Pascoe, J., Rajaretnam, N., Bulathsinhala, S., Davidson, B., Fusai, G., Hidalgo Salinas, C., Machairas, N., Pissanou, T., Pollok, J. M., Raptis, D. A., Soggiu, F., Tzerbinis, H., Xyda, S. E., Beamish, A., Davies, E., Foulkes, R., Magowan, D., Nassa, H., Ooi, R., Price, C., Solari, F., Tang, A., Williams, G., Al-Tamimi, Y., Bacon, A., Beasley, N., Chew, D., Crank, M., Ilenkovan, N., Macdonald, M., Narice, B., Rominiyi, O., Thompson, A., Varley, I., Drake, T., Harrison, E., Linder, G., Mayes, J., Mcgregor, R., Skipworth, R., Zamvar, V., Hawkin, P., Raymond, T., Ryska, O., Baron, R., Dunne, D., Gahunia, S., Halloran, C., Howes, N., Mckinney, R., Mcnicol, F., Russ, J., Szatmary, P., Tan, J. R., Thomas, A., Whelan, P., Anzak, A., Banerjee, A., Fuwa, O., Hughes, F., Jayasinghe, J. D., Knowles, C., Kocher, H., Leal Silva, I., Ledesma, F. S., Minicozzi, A., Navaratne, L., Rahman, R., Ramamoorthy, R., Sohrabi, C., Thaha, M., Thakur, B., Yip, V., Baumber, R., Parry, J., Evans, S., Jeys, L., Morris, G., Parry, M., Ahmadi, N., Aresu, G., Barrett-Brown, Z. M., Coonar, A. S., Durio Yates, H., Gearon, D., Hogan, J., King, M., Peryt, A., Pradeep, I. S., Adishesh, M., Atherton, R., Baxter, K., Brocklehurst, M., Chaudhury, M., Krishnamohan, N., Mcaleer, J., Owens, G., Parkin, E., Patkar, P., Phang, I., Aladeojebi, A., Ali, M., Barmayehvar, B., Gaunt, A., Gowda, M., Halliday, E., Kitchen, M., Mansour, F., Thomas, M., Zakai, D., Abbassi-Ghadi, N., Assalaarachchi, H., Currie, A., Flavin, M., Frampton, A., Hague, M., Hammer, C., Hopper, J., Horsnell, J., Humphries, S., Kamocka, A., Madhuri, T. K., Preston, S., Singh, P., Stebbing, J., Tailor, A., Walker, D., Aljanadi, F., Jones, M., Mhandu, P., O'Donnell, C., Turkington, R., Al-Ishaq, Z., Bhasin, S., Bodla, A. S., Burahee, A., Crichton, A., Fossett, R., Pigadas, N., Pickford, S., Rahman, E., Snee, D., Yassin, N., Fountain, D., Hasan, M. T., Karabatsou, K., Laurente, R., Pathmanaban, O., Al-Mukhtar, A., Giblin, A., Kelty, C., Lee, M., Lye, G., Newman, T., Sharkey, A., Steele, C., Sureshkumar Shah, N., Whitehall, E., Athwal, R., Baker, A., Jones, L., Konstantinou, C., Ramcharan, S., Vatish, J., Wilkin, R., Ethunandan, M., Sekhon, G. K., Shields, H., Singh, R., Wensley, F., Lawday, S., Lyons, A., Abbott, T., Anwar, S., Ghufoor, K., Chung, E., Hagger, R., Hainsworth, A., Karim, A., Owen, H., Ramwell, A., Williams, K., Baker, C., Davies, A., Gossage, J., Kelly, M., Knight, W., Hall, J., Harris, G., James, G., Kang, C., Lin, D. J., Rajgor, A. D., Royle, T., Scurrah, R., Steel, B., Watson, L. J., Choi, D., Hutchison, R., Jain, A., Luoma, V., Marcus, H., May, R., Menon, A., Pramodana, B., Webber, L., Aneke, I. A., Asaad, P., Brown, B., Collis, J., Duff, S., Moura, F., Wadham, B., Warburton, H., Elmoslemany, T., Jenkinson, M., Millward, C., Zakaria, R., Mccluney, S., Parmar, C., Shah, S., Allison, J., Babar, M. S., Collard, B., Goodrum, S., Lau, K., Scott, R., Thomas, E., Whitmore, H., Balasubramaniam, D., Jayasankar, B., Kapoor, S., Ramachandran, A., Elhamshary, A., Imam, S. M. B., Kapriniotis, K., Kasivisvanathan, V., Lindsay, J., Rakhshani-Moghadam, S., Beech, N., Chand, M., Green, L., Kalavrezos, N., Kiconco, H., Mcewen, R., Schilling, C., Sinha, D., Pereca, J., Chopra, S., Egbeare, D., Thomas, R., Combellack, T., Jones, S. E. F., Kornaszewska, M., Mohammed, M., Sharma, A., Tahhan, G., Valtzoglou, V., Williams, J., Eskander, P., Gash, K., Gourbault, L., Hanna, M., Maccabe, T., Newton, C., Olivier, J., Rozwadowski, S., Teh, E., West, D., Al-Omishy, H., Baig, M., Bates, H., Di Taranto, G., Dickson, K., Dunne, N., Gill, C., Howe, D., Jeevan, D., Khajuria, A., Martin-Ucar, A., Mcevoy, K., Naredla, P., Robertson, S., Sait, M., Sarma, D. R., Shanbhag, S., Shortland, T., Simmonds, S., Skillman, J., Tewari, N., Walton, G., Akhtar, M. A., Brunt, A., Mcintyre, J., Milne, K., Rashid, M. 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Royle, T, Scurrah, R, Steel, B, J Watson, L, Choi, D, Hutchison, R, Jain, A, Luoma, V, Marcus, H, May, R, Menon, A, Pramodana, B, Webber, L, A Aneke, I, Asaad, P, Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Wadham, B, Warburton, H, Elmoslemany, T, Jenkinson, M, Millward, C, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, S Babar, M, Collard, B, Goodrum, S, Lau, K, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Elhamshary, A, Imam, Smb, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, Mcewen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Combellack, T, Jones, Sef, Kornaszewska, M, Mohammed, M, Sharma, A, Tahhan, G, Valtzoglou, V, Williams, J, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, T, Newton, C, Olivier, J, Rozwadowski, S, Teh, E, West, D, Al-Omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar AMcEvoy, K, Naredla, P, Robertson, S, Sait, M, R Sarma, D, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, A Akhtar, M, Brunt, A, Mcintyre, J, Milne, K, M Rashid, M, Sgro, A, E Stewart, K, Turnbull, A, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Patki, P, Tanabalan, C, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, Macdonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Jones, R, S Kolli, V, K Lala, A, Leeson, S, Peevor, R, Seymour, Z, Chen, L, Henderson, E, Loehrer, A, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, Mcelhinney, K, Olson, K, C Osterberg, E, Riley, C, Srikanth, P, Thornhill, M, Blazer, D, Dilalla, G, S Hwang, E, Lee, W, Lidsky, M, Plichta, J, Rosenberger, L, Scheri, R, Turnage, K, Visgauss, J, Zani, S, Farma, J, Clark, J, Kwon, D, Etchill, E, E Gabre-Kidan AJenny, H, Kent, A, Ladd, M, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Brown, L, Ganly, I, Mullinax, J, Gusani, N, Hazelton, J, Maines, J, S Oh, J, Ssentongo, A, Ssentongo, P, Azam, M, Choudhry, A, Marx, W, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, K Abel, M, Andaya, V, Bigay, K, A Boeck, M, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, Bc, Heaton, C, Hirose, K, M Jablons, D, Kirkwood, K, Z Kornblith, L, R Kratz, J, Lee, R, N Miller, P, Nakakura, E, Nunez-Garcia, B, O'Donnell, R, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, M, Wai, K, Wustrack, R, J Xu, M, Beswick, D, Goddard, J, Manor, J, Song, J, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, L Roland, C, N Zafar, S, Abdallah, M, Abouassi, A, Almasri, M, Kulkarni, G, Marwan, H, Mehdi, M, Aoun, S, S Ban, V, H Batjer, H, Caruso, J, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, P, Hawkins, A, Maiga, A, Laufer, J, Scasso, S, Surgery, Graduate School, Glasbey, J, Nepogodiev, D, Simoes, J, Omar, O, Li, E, Abou Chaar, M, Chaudhry, D, Videria, J, Gujjuri, R, Kaafarani, H, Minaya-Bravo, A, Mckay, S, Roberts, K, Miguel-Mendez, C, Smart, N, Stewart, G, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), COVIDSurg Collaborative, Kolias, Angelos [0000-0003-3992-0587], Stewart, Grant [0000-0003-3188-9140], Apollo - University of Cambridge Repository, Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Pgdme, Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I, Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar Mrcog S, Vidya R, Bhangu AA, COVIDSurg Collaborative, Palmerini Emanuela, Frisoni Tommaso, Donati Davide, A Belvedere, P Bernante, P Bertoglio, S Boussedra, E Brunocilla, R Cipriani, G Cisternino, E De Crescenzo, P De Iaco, G Dondi, F Frio, E Jovine, F Mineo Bianchi, J Neri, D Parlanti, A M Perrone, A P Pezzuto, M Pignatti, V Pinto, G Poggioli, M Ravaioli, M Rottoli, R Schiavina, M Serenari, M Serra, P Solli, M Taffurelli, M Tanzanu, M Tesei, T Violante, S Zanotti, V Tonini, M Cervellera, A Gori, L Sartarelli, Glasbey, James C, Simoes, Joana F F, Venn, Mary L, Pgdme, null, Abou Chaar, Mohammad K, Edwards, Jonathan G, Evans, Jonathan P, Videria, Jose Flavio, Ford, Samuel J, Griffiths, Ewen A, Gujjuri, Rohan R, Kolias, Angelos G, Kaafarani, Haytham M A, McKay, Siobhan C, Mohan, Helen M, Roberts, Keith J, Smart, Neil J, Stewart, Grant D, Sundar Mrcog, Sudha, and Bhangu, Aneel A, Toia, F
Subjects: Male, Cancer Research, Outcome Assessment, International Cooperation, Settore MED/18 - CHIRURGIA GENERALE, Settore MED/19 - Chirurgia Plastica, 030230 surgery, Aged, Aged, 80 and over, COVID-19, Cohort Studies, Critical Care, Elective Surgical Procedures, Epidemics, Female, Humans, Logistic Models, Middle Aged, Neoplasms, Outcome Assessment, Health Care, Postoperative Complications, SARS-CoV-2, 0302 clinical medicine, Operating theater, cohort studies, Health care, middle aged, 80 and over, Medicine, Lung, Cancer, COVID-19/epidemiology, OUTCOMES, Manchester Cancer Research Centre, Pulmonary Complication, ORIGINAL REPORTS, aged, Oncology, 030220 oncology & carcinogenesis, Pneumonia & Influenza, Patient Safety, Elective Surgical Procedure, Life Sciences & Biomedicine, 6.4 Surgery, Cohort study, Human, medicine.medical_specialty, elective surgical procedures/methods, Logistic Model, Health Care, Clinical Sciences, Oncology and Carcinogenesis, Epidemic, [SDV.CAN]Life Sciences [q-bio]/Cancer, cancer surgery, SARS-CoV-2 pandemic, epidemics, COVIDSurg Collaborative, NO, outcome assessment, health care/methods, 03 medical and health sciences, male, Settore MED/28 - Malattie Odontostomatologiche, Clinical Research, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Elective surgery, Elective Cancer Surgery in SARS-CoV-2, Elective Cancer Surgery in COVID-19, covid 19, sars-cov-2, Science & Technology, business.industry, Prevention, ResearchInstitutes_Networks_Beacons/mcrc, Evaluation of treatments and therapeutic interventions, 1103 Clinical Sciences, Pneumonia, Odds ratio, medicine.disease, Good Health and Well Being, neoplasms/surgery, critical care/methods, Emergency medicine, postoperative complications/prevention & control, Neoplasm, Postoperative Complication, Cohort Studie, business, aged, 80 and over, SARS-CoV-2/physiology, logistic models
Abstract: PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks. Copyright © 2020 American Society of Clinical Oncology. All rights reserved. Bowel and Cancer Research; Sarcoma UK; Yorkshire Cancer Research; European Society of Coloproctology; National Institute for Health Research: 16.136.79; Bowel Disease Research Foundation; Urology Foundation Supported by a National Institute for Health Research (NIHR) Global Health Research Unit grant (NIHR 16.136.79) using UK aid from the UK government to support global health research, Association of Coloproctology of Great Britain and Ireland, Bowel & Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research. The funders had no role in the study design; data collection, analysis, and interpretation; or writing of this report. The views expressed are those of the authors and not necessarily those of the National Health Service, NIHR, or UK Department of Health and Social Care.
Published: 2021
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31. Repeat preoperative endoscopy after regional implementation of electronic synoptic endoscopy reporting: a retrospective comparative study

Author: David J. Hochman, Jason Park, Harminder Singh, Olivia Hershorn, Ashley Vergis, Ramzi M. Helewa, and Garrett G R J Johnson
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Colorectal cancer, General surgery, Colonoscopy, Guideline, Hepatology, medicine.disease, Synoptic report, Endoscopy, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, Bowel preparation, 030211 gastroenterology & hepatology, Surgery, business, Abdominal surgery
Abstract: Repeat preoperative endoscopy is common for patients with colorectal neoplasms. This can result in treatment delays, patient discomfort, and risks of colonoscopy-related complications. Repeat preoperative endoscopy has been attributed to poor communication between endoscopists and surgeons. In January 2019, mandatory electronic synoptic reporting for endoscopy was implemented to include elements consistent with quality indicators proposed in national guidelines. The aim of the present study is to assess whether the repeat preoperative endoscopy rate for colorectal lesions changed following synoptic report implementation. A retrospective review was performed of 1690 consecutive patients who underwent elective surgical resection for colorectal neoplasms from January 2007 to June 2020 at a tertiary hospital in Canada. Patients who had an index endoscopy documented via synoptic report were compared to those reported via narrative report. Primary outcomes were rates of repeat preoperative endoscopy and inclusion of colonoscopy quality indicators: photo-documentation, tattoo placement, and bowel preparation score. In total, 1429 patients who underwent elective colorectal resection for colorectal cancers or polyps between January 2007 and June 2020 were included. 115 had index endoscopies recorded via synoptic report and 1314 by narrative report. The repeat preoperative endoscopy rate after endoscopies documented by narrative report was 29.07% (95% CI 26.63–31.61) and 25.22% (95% CI 17.58–34.17%) for synoptic report. Patients whose index endoscopies where performed by a practitioner other than their operating surgeon had a re-endoscopy rate of 36.03% (95% CI 32.82–39.33%) after narrative report and 38.81% (95% CI 27.14–51.50%) for synoptic report. Rates of tattoo placement, photo-documentation, and reporting of bowel preparation quality were all significantly increased with synoptic reports (p ≤ 0.003). Endoscopy synoptic reports based on current guidelines were not associated with a decrease in rates of repeat pre-operative endoscopy at a high-volume colorectal cancer centre. Future study should examine guideline deficiencies for this purpose and make necessary modifications.
Published: 2021
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32. Parenting Styles and Psychiatric Profile of Parents of Adult Substance Use Disorder Patients: Cross-sectional Study

Author: Wadih Naja, Ramzi Haddad, Athar Halabi, Michèle Chahoud, Alexandra Badaoui, and Carmen Zrour
Subjects: medicine.medical_specialty, education.field_of_study, Cross-sectional study, Population, 030508 substance abuse, Alcohol abuse, medicine.disease, 030227 psychiatry, Substance abuse, 03 medical and health sciences, Psychiatry and Mental health, Birth order, 0302 clinical medicine, Mood, medicine, Parenting styles, Anxiety, medicine.symptom, 0305 other medical science, Psychiatry, education, Psychology
Abstract: The purpose of this Lebanese, cross-sectional, multi-centric study is to examine the prevalence of psychiatric disorders among adult patients with substance use disorder and their parents along with the predominant parenting style. A total of 100 patients suffering from a substance use disorder, and their parents (N = 127) were administered the translated Arabic version of the MINI to diagnose lifetime psychiatric disorders. The Parental Authority Questionnaire (PAQ) in its translated validated Arabic version was filled by patients to detect the predominant parenting style. The least common parenting style reported was authoritative (25%). The parents’ prevalence of nicotine dependence, alcohol abuse and dependence, and illicit substance abuse and dependence were considerably higher than the general population. Mood and anxiety disorders were more prevalent among patients and their parents compared to the Lebanese general population. In the bivariate analysis, no significant association was found between the perceived parenting style (authoritative and non-authoritative) and parents’ economic (p = 0.545) and civil status (p = 0.231), patient’s gender (p = 0.390), birth order (p = 0.084), and parents’ and offspring psychiatric disorder. Hence, an underlying genetic and environmental mechanism could potentially explain our findings rather than a rearing problem; however, further studies with larger sample size are needed to confirm this hypothesis.
Published: 2021
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33. Association of health warning labels and motivation to quit waterpipe tobacco smoking among university students in the Eastern Mediterranean Region

Author: James F. Thrasher, Aya Mostafa, Dina Farran, Randah R. Hamadeh, Juhan Lee, Grace Khawam, Ramzi G. Salloum, Mohamed Salama, Niveen M E Abu-Rmeileh, Khalid A. Kheirallah, Muhammad W. Darawad, and Rima Nakkash
Subjects: Health (social science), Epidemiology, media_common.quotation_subject, Health Professions (miscellaneous), motivation to quit, university, Waterpipe Tobacco, Medicine, Palestine, Association (psychology), education, media_common, Multinomial logistic regression, waterpipe, education.field_of_study, Pregnancy, students, warning labels, business.industry, Addiction, Public Health, Environmental and Occupational Health, medicine.disease, Eastern mediterranean, Warning label, Public aspects of medicine, RA1-1270, business, Research Paper, Demography
Abstract: Introduction This study aimed to determine associations between health warning label content and motivation to quit waterpipe smoking by gender and smoking location. Methods Convenience samples of university students in three Eastern Mediterranean countries - Egypt (n=442), Jordan (n=535) and Palestine (n=487) - completed an online survey assessing health warning labels. Multinomial logit regression models were conducted to determine the association between different variables, particularly gender and smoking location, with motivation to quit. Results In Palestine, female smokers were more motivated to quit waterpipe smoking when seeing textual warning labels related to children (T2) and pregnancy (T6) [T2: 1.8 (95% CI: 1.1-2.8), T6: 2.7 (95% CI: 1.6-4.3)] compared to males. Similar results were found in Jordan [T2: 1.6 (95% CI: 1.0-2.6), T6: 1.8 (95% CI: 1.1-3.0)]. As for the smoking location, home-only smokers in Palestine were more likely to quit in response to the following warnings: waterpipe smoking is addictive T1: 2.3 (95% CI: 1.4-3.7), harmful for children T2: 2.3 (95% CI: 1.4-4.1), harmful for the baby during pregnancy T6: 2.4 (95% CI: 1.3-4.3), and to believe that quitting reduces the health risks T9: 1.8 (95% CI: 1.0-3.1). These results were not found in Jordan nor Egypt. Smokers reported that the most noticeable location of a HWL on a waterpipe device is the mouthpiece. Conclusions A better understanding of motivation to quit and its association with various warnings and smoking location could guide countries on which warnings to require in legislation and where best to require them particularly in relation to location.
Published: 2021
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34. Clinical Efficacy of the Use of Honey as Wound Treatment in Surgical Site Infection due to Hysterectomy Patient with Type 2 Diabetes Mellitus

Author: Ramzi Amin, Hartati, Ferry Yusrizal, Cindy Kesty, Mufida Muzakkie, Vicela Patricia Virgyna, and Yusuf Effendi
Subjects: medicine.medical_specialty, Hysterectomy, integumentary system, business.industry, Wound dehiscence, medicine.medical_treatment, Transverse colon, Type 2 Diabetes Mellitus, Scars, Surgical wound, RM1-950, wound dressing, medicine.disease, Surgery, Wound care, Diabetes mellitus, honey dressing, medicine, wound infection, Therapeutics. Pharmacology, Neurology. Diseases of the nervous system, medicine.symptom, RC346-429, business
Abstract: Introduction: Honey is believed to be used in the topical treatment of wounds and burns due to its anti-bacterial and wound healing promotion activities. The sugar content in honey is high enough to inhibit microbial growth. This case report reports the clinical efficacy of using honey as a postoperative hysterectomy wound dressing with type 2 diabetes mellitus complications. Case Presentation: A woman, 40 years old, lived in Palembang, housewife, came with complaints of open surgical scars and smelling pus. The patient is a postoperative patient with cesarean section with indications of a prolonged latent phase and macrosomia. The patient also had a history of uncontrolled diabetes mellitus since 8 years ago. Intraoperatively, a wound dehiscence is obtained in the lower uterine segment and adhesions between the anterior uterine body and the omentum and transverse colon. The patient finally underwent a supracervical hysterectomy and the surgical secretions were examined for bacterial culture and antibiotic resistance. During wound care, the patient's surgical wound was treated using honey dressings. Patient experienced improvement after treatment for 12 days post-operation. Conclusion: Honey has antibacterial and tissue regeneration ability which is high enough to heal surgical wounds. Further studies are needed for the application of honey to postoperative wounds more widely
Published: 2021
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35. Association between ABCB1 polymorphisms and response to antiepileptic drugs among Jordanian epileptic patients

Author: Rami Abduljabbar, Duaa Eid Tamimi, Mohammed Zawiah, Ramzi Mukred Saeed, and Al-Motassem Yousef
Subjects: 0301 basic medicine, Drug, medicine.medical_specialty, business.industry, media_common.quotation_subject, Haplotype, Single-nucleotide polymorphism, General Medicine, Drug resistance, medicine.disease, Gastroenterology, 03 medical and health sciences, Epilepsy, 030104 developmental biology, 0302 clinical medicine, Neurology, Internal medicine, Genotype, medicine, Neurology (clinical), Allele, business, Genotyping, 030217 neurology & neurosurgery, media_common
Abstract: Background Genetic polymorphisms of drug efflux transporters as ATP-binding cassette subfamily B, member 1 (ABCB1) have been suggested to modulate antiepileptic drugs (AEDs) response. We aimed to explore the association of ABCB1 polymorphisms and AEDs resistance among epileptic patients. Methods A total of 86 Jordanian epileptic patients treated with AEDs was included in the study. DNA was extracted from blood samples and genotyping and haplotypes analyses were conducted for Nine single nucleotide polymorphisms (SNPs) on the ABCB1 gene. Results Data revealed that none of the examined SNPs were associated with resistance to AEDs neither on the level of alleles nor genotypes. However, strong association was found between rs2235048 (OR = 10.6; 95%CI = [1.89-59.8], p= 0.01), rs1045642 (OR = 14; 95%CI = [1.3-156.7], p= 0.02), rs2032582 (OR = 9.1; 95%CI = [1.4-57.3], p= 0.04) and rs1128503 (OR = 18.7; 95%CI = [1.6-222.9], p= 0.02), ABCB1 polymorphisms and resistance to AEDs among females but not males. Haplotype analysis revealed statistically significant associations. The strongest significant associations were for haplotypes containing 2677G_1236 T in two-SNPshaplotypes (OR = 4.2; 95%CI = [1.2-14.9], p = 0.024); three-SNPs-haplotypes (OR = 4.2; 95% CI = [1.2-14.9], p = 0.02); four-SNPs-haplotypes (OR = 4.1; 95%CI = [1.2-14.3], p = 0.026). Conclusion Data suggests that there is a gender dependent association between ABCB1 genetic polymorphisms and response to AEDs. Additionally, ABCB1 haplotypes influence the response to AEDs. Further investigation is needed to confirm the results of this study.
Published: 2021
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36. Pharmacists’ knowledge, attitudes, beliefs, and barriers toward breast cancer health promotion: a cross-sectional study in the Palestinian territories

Author: Hiba Awawdeh and Ramzi Shawahna
Subjects: Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Attitude of Health Personnel, Cross-sectional study, media_common.quotation_subject, health care facilities, manpower, and services, education, Breast Neoplasms, Community Pharmacy Services, Health Promotion, Pharmacists, Health administration, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Promotion (rank), Surveys and Questionnaires, health services administration, Humans, Medicine, 030212 general & internal medicine, Signs and symptoms, health care economics and organizations, media_common, business.industry, Health Policy, Nursing research, Public health, Cancer, Awareness, medicine.disease, Health services, Arabs, Cross-Sectional Studies, Health promotion, 030220 oncology & carcinogenesis, Family medicine, Screening, Female, Public aspects of medicine, RA1-1270, business, Research Article
Abstract: BackgroundAmong all cancers, breast cancer is the most prevalent cancer and the leading cause of mortality among women in developing countries including Palestine. Community pharmacists are trusted and easily accessible healthcare providers who could be engaged in breast cancer health promotion. This study was conducted with the aim of exploring knowledge, attitudes, beliefs, and barriers toward breast cancer health promotion among community pharmacists in the Palestinian territories.MethodsThis study was conducted in a cross-sectional design using a questionnaire among community pharmacists. Knowledge of community pharmacists of breast cancer was tested using a 26-item knowledge test. Attitudes and beliefs of the community pharmacists with regard to breast cancer promotion were explored using 14 items. Barrier to breast cancer health promotion were explored using 9 items.ResultsData were collected from 200 community pharmacists. The median knowledge score was 69.2 % with and IQR of 15.2 %. Of the community pharmacists, 67.5 % scored 50 % and above in the knowledge test. Multivariate logistic regression showed that community pharmacists who were female in gender were more likely to score 50 % and above in the knowledge test compared to the community pharmacists who were male in gender (OR = 4.73, 95 % CI of 2.26–9.89). The community pharmacists had positive attitudes toward breast cancer health promotion. There was a significant moderate positive correlation between knowledge and attitudes scores (Spearman’s rho = 0.37,p-value 60.0 %).ConclusionsThis study shed light on the role of community pharmacists in breast cancer health promotion. Pharmacists had good knowledge of breast cancer and positive attitudes toward promoting the health of patients with breast cancer. Further studies are still needed to determine how to integrate community pharmacists in the team of healthcare providers caring for patients with breast cancer.
Published: 2021

37. Preventing Coronary Obstruction During Transcatheter Aortic Valve Replacement

Author: Ramzi Khalil, J Bradley Oldemeyer, Jaffar M. Khan, Howard C. Herrmann, John Lisko, Robert J. Lederman, Adnan K. Chhatriwalla, Paul Mahoney, Rachel L Koch, David V. Daniels, Itsik Ben-Dor, Andrei Pop, Roger J. Laham, Emily Perdoncin, Brian Whisenant, Vasilis C. Babaliaros, Peter S. Fail, Gilbert H.L. Tang, James M. McCabe, Ming Zhang, Christian Spies, Adam B Greenbaum, Jeremiah P. Depta, Isaac George, Toby Rogers, Robert A. Leonardi, Lowell F. Satler, Cheng Zhang, Jonas Lanz, Shahram Yazdani, Jeffrey E. Cohen, Ron Waksman, Ashish Pershad, Shikhar Agarwal, Kamran I. Muhammad, Pinak B. Shah, and George Hanzel
Subjects: medicine.medical_specialty, Transcatheter aortic, business.industry, medicine.medical_treatment, 030204 cardiovascular system & hematology, medicine.disease, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Valve replacement, Cohort, medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Stroke, Embolic protection, Artery
Abstract: Objectives This study sought to determine the safety of the BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction) procedure. Background Transcatheter aortic valve replacement causes coronary artery obstruction in 0.7% of cases, with 40% to 50% mortality. BASILICA is a procedure to prevent coronary obstruction. Safety and feasibility in a large patient cohort is lacking. Methods The international BASILICA registry was a retrospective, multicenter, real-world registry of patients at risk of coronary artery obstruction undergoing BASILICA and transcatheter aortic valve replacement. Valve Academic Research Consortium-2 definitions were used to adjudicate events. Results Between June 2017 and December 2020, 214 patients were included from 25 centers in North America and Europe; 72.8% had bioprosthetic aortic valves and 78.5% underwent solo BASILICA. Leaflet traversal was successful in 94.9% and leaflet laceration in 94.4%. Partial or complete coronary artery obstruction was seen in 4.7%. Procedure success, defined as successful BASILICA traversal and laceration without mortality, coronary obstruction, or emergency intervention, was achieved in 86.9%. Thirty-day mortality was 2.8% and stroke was 2.8%, with 0.5% disabling stroke. Thirty-day death and disabling stroke were seen in 3.4%. Valve Academic Research Consortium-2 composite safety was achieved in 82.8%. One-year survival was 83.9%. Outcomes were similar between solo and doppio BASILICA, between native and bioprosthetic valves, and with the use of cerebral embolic protection. Conclusions BASILICA is safe, with low reported rates of stroke and death. BASILICA is feasible in the real-world setting, with a high procedure success rate and low rates of coronary artery obstruction.
Published: 2021
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38. Acute pericarditis: A peculiar manifestation of common variable immune deficiency

Author: Hamed Talakoob, Shahrooz Yazdani, Hossein Karim, Mahnaz Jamee, Nasim Ramzi, and Gholamreza Azizi
Subjects: Adult, Pulmonary and Respiratory Medicine, Recurrent infections, Pediatrics, medicine.medical_specialty, Immunology, Iran, Pericardial Effusion, 03 medical and health sciences, Fatal Outcome, 0302 clinical medicine, Acute pericarditis, Immunity, Prevalence, medicine, Humans, Pericarditis, Immunology and Allergy, Medical history, Child, Retrospective Studies, Past medical history, business.industry, Common variable immunodeficiency, Pneumonia, General Medicine, medicine.disease, Common Variable Immunodeficiency, 030228 respiratory system, Child, Preschool, Acute Disease, Female, business, Complication, 030215 immunology
Abstract: Common variable immune deficiency (CVID) is known as the most prevalent symptomatic inborn error of immunity associated with autoimmune and inflammatory complications in addition to recurrent infections. In this study, we investigated the prevalence of acute pericarditis as a complication in the past medical history of 337 CVID patients. We found five patients (1.5%) that had experienced acute pericarditis, and described the medical history of three patients.
Published: 2021
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39. Improving outcome prediction in individuals with colorectal cancer and diabetes by accurate assessment of vascular complications: Implications for clinical practice

Author: Eva Morris, Amy Downing, P. J. Finan, Ramzi A. Ajjan, Rebecca J. Birch, and Simon J. Howell
Subjects: Adult, Male, medicine.medical_specialty, Colorectal cancer, Population, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, 030202 anesthesiology, Internal medicine, Diabetes mellitus, Humans, Medicine, 030212 general & internal medicine, Risk factor, education, Aged, Aged, 80 and over, Diabetes Complication, education.field_of_study, business.industry, Cancer, General Medicine, Middle Aged, medicine.disease, Comorbidity, Oncology, Female, Surgery, Colorectal Neoplasms, business, Complication, Diabetic Angiopathies
Abstract: Background: Diabetes is considered a risk factor for mortality following a diagnosis of cancer. We hypothesised that the risk will vary due to the heterogeneous nature of the population and accurate classification of vascular complications will improve prediction of clinical outcomes. Methods: The COloRECTal cancer data Repository (CORECT-R) was used to identify individuals with primary colorectal cancer, who underwent surgical resection in England (2005–2016). Diabetes was recorded using ICD10 codes (E10-E14) during inpatient hospital admission in the six years preceding cancer diagnosis, complication status was determined using the adapted Diabetes Complications Severity Index (aDCSI). Survival and post-operative outcomes were compared between groups. Results: Of 232,367 individuals, 28,642 (12.3%) were recorded as having diabetes, 49.2% of whom had complications according to the aDCSI. Patients with diabetes complications had increased incidence of adverse post-operative outcomes (90-day post-operative mortality (6.6% versus 3.2%) and death during the surgical episode (7.9% versus 3.6%)), compared to those without diabetes. Those without complications had rates comparable to the population without diabetes. The odds of death within a year of diagnosis were higher for those with complicated diabetes compared to those without diabetes [OR 1.58 (95%CI 1.51–1.66) p
Published: 2021
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40. Hip joint space width in an asymptomatic population: Computed tomography analysis according to femoroacetabular impingement morphologies

Author: Ramzi C Moucharafieh, Raja Ashou, Hicham Abdelnour, Rami Ayoubi, Joseph Maalouly, Alexandre Nehme, and Gerard El-Hajj
Subjects: musculoskeletal diseases, Population, Physical Therapy, Sports Therapy and Rehabilitation, Computed tomography, Osteoarthritis, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Pincer, medicine, Orthopedics and Sports Medicine, lcsh:Sports medicine, education, Joint (geology), Femoroacetabular impingement, Hip surgery, 030222 orthopedics, education.field_of_study, Wear out, Cam, medicine.diagnostic_test, business.industry, Rehabilitation, 030229 sport sciences, medicine.disease, Femoroacetabular impingement syndrome, Original Article, medicine.symptom, Joint space width, Nuclear medicine, business, lcsh:RC1200-1245
Abstract: Background Although the association between femoroacetabular impingement (FAI) syndrome and hip osteoarthritis (OA) is well established, not all hips exhibiting cam or pincer morphologies (i.e. imaging findings of FAI syndrome) are symptomatic or arthritic. It is difficult to detect which subgroup will wear out, or how does the arthritic process start radiographically. Therefore, we measured in a retrospective study based on computed tomography (CT) analysis, the joint space width (JSW) according to a standard protocol and we investigated its variation according to the presence of a cam and/or pincer morphology. We hypothesized that the radiological presence of a cam and/or pincer hip morphologies, even in asymptomatic subjects, would affect JSW. Methods Two hundred pelvic CT scans performed for non-orthopedic etiologies in asymptomatic patients were analyzed using a 3D software. After excluding patients with hip OA or previous hip surgery, 194 pelvic CT scans (388 hips) were retained. We measured for each hip the presence of FAI syndrome imaging findings (cam and pincer morphologies) using the classical parameters of coxometry. In addition, we performed a measurement of articular joint space width according to a standard protocol. We then calculated the mean thickness of 3 defined regions along the femoroacetabular joint: anterior-superior, posterior-inferior, and posterior-superior. Lastly, we compared the JSW across 4 groups: hips with (1) no cam or pincer, (2) pincer, (3) cam, and (4) cam and pincer morphologies using a multivariate analysis. Additionally, a topographic heatmap of JSW was plotted allowing quantitative representation of JSW along the joint. Results Increased JSW with peak difference of 0.9 mm (25.7%) was found in hips with cam and pincer morphologies when compared to normal ones (p = 0.002) and to hips with pincer or cam morphologies only. Conclusion Positive variations in JSW were associated to the presence of cam and pincer morphologies. This significant increase in JSW could be one of the earliest measurable changes preceding later classical alterations., Graphical abstract Image 1
Published: 2021

41. Reversible Coronary Artery Aneurysm With Delayed Anti-inflammatory Therapy in Multisystem Inflammatory Syndrome in Children

Author: Mark Gorelik, Sanghee Suh, Patrick T. Wilson, Ramzi Shaykh, Shoshana Leftin, Robert Spencer, and Rebekah Diamond
Subjects: 0301 basic medicine, Tachycardia, medicine.medical_specialty, 2019-20 coronavirus outbreak, coronary vessel anomaly, medicine.drug_class, Hemodynamics, Case Report, Disease, 030105 genetics & heredity, hemodynamics, tachycardia, Anti-inflammatory, LAD, left anterior descending, 03 medical and health sciences, 0302 clinical medicine, Clinical Case, shortness of breath, Internal medicine, Medicine, echocardiography, Diseases of the circulatory (Cardiovascular) system, Coronary artery aneurysm, business.industry, SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2, autoimmune, Delayed treatment, KD, Kawasaki disease, medicine.disease, Natural history, HD, hospital day, RC666-701, Cardiology, NT-proBNP, N-terminal pro–B-type natriuretic peptide, MIS-C, multisystem inflammatory syndrome in children, medicine.symptom, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract: A 4-year-old boy with multisystem inflammatory syndrome in children before widespread recognition of this disease developed complications, including coronary artery aneurysm, without anti-inflammatory treatment. With delayed treatment, all sequelae resolved. This case demonstrates a natural history supporting the role of anti-inflammatory treatment even with delayed or equivocal diagnosis. (Level of Difficulty: Intermediate.), Graphical abstract
Published: 2021

42. Triggers and oncologic outcome of salvage radical prostatectomy, salvage radiotherapy and active surveillance after focal therapy of prostate cancer

Author: Daniel Koch, Daniel Schindele, Sami-Ramzi Leyh-Bannurah, Katharina S. Mala, Angelika Borkowetz, Johannes Bruendl, Martin Schostak, Andreas Blana, Jost von Hardenberg, T. Kuru, Niklas Westhoff, Karl-Friedrich Kowalewski, and Hannes Cash
Subjects: Nephrology, Male, medicine.medical_specialty, Urology, medicine.medical_treatment, Partial gland ablation, Salvage therapy, Kaplan-Meier Estimate, Prostate cancer, Focal therapy, Internal medicine, Multiparametric magnetic resonance imaging, Biopsy, medicine, Hemi-ablation, Humans, Prostate neoplasms, Watchful Waiting, Aged, Prostatectomy, Salvage Therapy, medicine.diagnostic_test, Radiotherapy, business.industry, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, medicine.disease, Progression-Free Survival, Prostate-specific antigen, High-intensity focused ultrasound, Cohort, Multivariate Analysis, High-Intensity Focused Ultrasound Ablation, Regression Analysis, Prostate neoplasm, Original Article, Neoplasm Recurrence, Local, business
Abstract: Purpose Due to the tissue preserving approach of focal therapy (FT), local cancer relapse can occur. Uncertainty exists regarding triggers and outcome of salvage strategies. Methods Patients with biopsy-proven prostate cancer (PCa) after FT for localized PCa from 2011 to 2020 at eight tertiary referral hospitals in Germany that underwent salvage radical prostatectomy (S-RP), salvage radiotherapy (S-RT) or active surveillance (AS) were reported. Prostate specific antigen (PSA) changes, suspicious lesions on mpMRI and histopathological findings on biopsy were analyzed. A multivariable regression model was created for adverse pathological findings (APF) at S-RP specimen. Kaplan–Meier curves were generated to determine oncological outcomes. Results A total of 90 men were included. Cancer relapse after FT was detected at a median of 12 months (IQR 9–16). Of 50 men initially under AS 13 received S-RP or S-RT. In total, 44 men underwent S-RP and 13 S-RT. At cancer relapse 17 men (38.6%) in the S-RP group [S-RT n = 4 (30.8%); AS n = 3 (6%)] had ISUP > 2. APF (pT ≥ 3, ISUP ≥ 3, pN + or R1) were observed in 23 men (52.3%). A higher ISUP on biopsy was associated with APF [p = 0.006 (HR 2.32, 97.5% CI 1.35–4.59)] on univariable analysis. Progression-free survival was 80.4% after S-RP and 100% after S-RT at 3 years. Secondary therapy-free survival was 41.7% at 3 years in men undergoing AS. Metastasis-free survival was 80% at 5 years for the whole cohort. Conclusion With early detection of cancer relapse after FT S-RP and S-RT provide sufficient oncologic control at short to intermediate follow-up. After AS, a high secondary-therapy rate was observed.
Published: 2021

43. Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

Author: Khatri, C, Ward, AE, Nepogodiev, D, Ahmed, I, Chaudhry, D, Dhaif, F, Bankhad-Kendall, B, Kaafarani, H, Bretherton, C, Mahmood, A, Marais, L, Parsons, N, Bhangu, A, Metcalfe, A, Siaw-Acheampong, K, Dawson, BE, Evans, JP, Glasbey, JC, Gujjuri, RR, Heritage, E, Jones, CS, Kamarajah, SK, Keatley, JM, Lawday, S, Li, E, Mckay, SC, Pellino, G, Tiwari, A, Simoes, JFF, Trout, IM, Venn, ML, Wilkin, RJW, Ademuyiwa, AO, Agarwal, A, Al Ameer, E, Alderson, D, Alser, O, Arnaud, AP, Augestad, KM, Bankhead-Kendall, B, Benson, RA, Chakrabortee, S, Blanco-Colino, R, Brar, A, Bravo, A Minaya, Breen, KA, Buarque, I Lima, Caruana, E, Cunha, MF, Davidson, GH, Desai, A, Di Saverio, S, Edwards, J, Elhadi, M, Farik, S, Fiore, M, Fitzgerald, JE, Ford, S, Gallo, G, Ghosh, D, Gomes, GMA, Griffiths, E, Halkias, C, Harrison, EM, Hutchinson, P, Isik, A, Kolias, A, Lawani, I, Lederhuber, H, Leventoglu, S, Loffler, MW, Martin, J, Mashbari, H, Mazingi, D, Mohan, H, Moore, R, Moszkowicz, D, Ng-Kamstra, JS, Metallidis, S, Moug, S, Niquen, M, Ntirenganya, F, Outani, O, Pata, F, Pinkney, TD, Pockney, P, Radenkovic, D, Ramos-De la Medina, A, Roberts, K, Santos, I, Schache, A, Schnitzbauer, A, Stewart, GD, Shaw, R, Shu, S, Soreide, K, Spinelli, A, Sundar, S, Tabiri, S, Townend, P, Tsoulfas, G, van Ramshorst, G, Vidya, R, Vimalachandran, D, Wright, N, Mak, JKC, Kulkarni, R, Sharma, N, Nankivell, P, Tirotta, F, Parente, A, Breik, O, Kisiel, A, Cato, LD, Saeed, S, Pathanki, AM, Almond, M, Kamal, M, Chebaro, A, Lecolle, K, Truant, S, El Amrani, M, Zerbib, P, Pruvot, FR, Mathieu, D, Surmei, E, Mattei, L, Marin, H, Dudek, J, Singhal, T, El-Hasani, S, Nehra, D, Walters, A, Cuschieri, J, Ho, M, Wade, RG, Johnstone, J, Bourke, G, Brunelli, A, Elkadi, H, Otify, M, Pompili, C, Burke, JR, Bagouri, E, Chowdhury, M, Abual-Rub, Z, Kaufmann, A, Munot, S, Lo, T, Young, A, Kowal, M, Wall, J, Peckham-Cooper, A, Winter, SC, Belcher, E, Stavroulias, D, Di Chiara, F, Wallwork, K, Qureishi, A, Lami, M, Sravanam, S, Mastoridis, S, Shah, K, Chidambaram, S, Smillie, R, Shaw, AV, Bandyopadhyay, S, Cernei, C, Jeyaretna, D, Ganau, M, Piper, RJ, Duck, E, Brown, S, Jelley, C, Tucker, SC, Bond-Smith, G, Griffin, XL, Tebala, GD, Neal, N, Vatish, M, Noton, TM, Ghattaura, H, Maher, M, Fu, H, Risk, OBF, Majd, Soleymani H, Sinha, S, Shankar, S, Aggarwal, A, Kharkar, H, Lakhoo, K, Verberne, C, Senent-Boza, A, Sanchez-Arteaga, A, Benitez-Linero, I, Manresa-Manresa, F, Tallon-Aguilar, L, Melero-Cortes, L, Fernandez-Marin, MR, Duran-Munoz-Cruzado, VM, Ramallo-Solis, I, Beltran-Miranda, P, Pareja-Ciuro, F, Anton-Eguia, BT, Dawson, AC, Drane, A, Oliva Mompean, F, Gomez-Rosado, J, Reguera-Rosal, J, Valdes-Hernandez, J, Capitan-Morales, L, del Toro Lopez, MD, Patel, M, Shabana, A, Alanbuki, A, Usman, O, Tang, A, Beamish, AJ, Price, C, Bosanquet, D, Magowan, D, Solari, F, Williams, G, Nassa, H, Smith, L, Elliott, L, Mccabe, G, Holroyd, D, Jamieson, NB, Mariani, NM, Nicastro, V, Li, Z, Parkins, K, Spencer, N, Harries, R, Egan, RJ, Motter, D, Jenvey, C, Mahoney, R, Fine, N, Minto, T, Henry, A, Gill, C, Dunne, N, Sarma, DR, Godbole, C, Carlos, W, Tewari, N, Jeevan, D, Naredla, P, Khajuria, A, Connolly, H, Robertson, S, Sweeney, C, Di Taranto, G, Shanbhag, S, Dickson, K, McEvoy, K, Skillman, J, Sait, M, Al-omishy, H, Baig, M, Heer, B, Lunevicius, R, Sheel, ARG, Sundhu, M, Santini, AJA, Fathelbab, MSAT, Hussein, KMA, Nunes, QM, Jones, RP, Shahzad, K, Haq, I, Baig, MMAS, Hughes, JL, Kattakayam, A, Rajput, K, Misra, N, Shah, SB, Clynch, AL, Georgopoulou, N, Sharples, HM, Apampa, AA, Nzenwa, IC, Sud, A, Podolsky, D, Coleman, NL, Callahan, MP, Dunstan, M, Beak, P, Gerogiannis, I, Ebrahim, A, Alwadiya, A, Goyal, A, Phillips, A, Bhalla, A, Demetriou, C, Grimley, E, Theophilidou, E, Ogden, E, Malcolm, FL, Davies-Jones, G, Ng, JCK, Mirza, M, Hassan, M, Elmaleh, N, Daliya, P, Williams, S, Bateman, A, Chia, Z, A'Court, J, Konarski, A, Faulkner, G, Talwar, R, Patel, K, Askari, A, Jambulingam, PS, Shaw, S, Maity, A, Hatzantonis, C, Sagar, J, Kudchadkar, S, Cirocchi, N, Chan, CH, Eberbach, H, Bayer, J, Erdle, B, Sandkamp, R, Breen, K, Velmahos, G, Maurer, LR, El Moheb, M, Gaitanidis, A, Naar, L, Christensen, MA, Kapoen, C, Langeveld, K, El Hechi, M, Mokhtari, A, Main, B, Maccabe, T, Newton, C, Blencowe, NS, Fudulu, DP, Bhojwani, D, Baquedano, M, Caputo, M, Rapetto, F, Flannery, O, Hassan, A, Ward, A, Tadross, D, Majkowski, L, Blundell, C, Forlani, S, Nair, R, Guha, S, Brown, SR, Steele, C, Kelty, CJ, Newman, T, Lee, M, Chetty, G, Lye, G, Balasubramanian, SP, Shah, Sureshkumar N, Sherif, M, Al-mukhtar, A, Whitehall, E, Giblin, A, Wells, F, Sharkey, A, Adamec, A, Madan, S, Konsten, J, Van Heinsbergen, M, Sou, A, Simpson, D, Hamilton, E, Blair, J, Jimeno Fraile, J, Morales-Garcia, D, Carrillo-Rivas, M, Toledo Martinez, E, Pascual, A, Landaluce-Olavarria, A, Gonzalez De Miguel, M, Gomez Cruzado, Fernandez L, Begona, E, Lecumberri, D, Calvo Rey, A, Prada Hervella, GM, Dos Santos Carregal, L, Rodriguez, Fernandez MI, Freijeiro, M, El Drubi Vega, S, Van den Eynde, J, Oosterlinck, W, Van den Eynde, R, Sermon, A, Boeckxstaens, A, Cordonnier, A, De Coster, J, Jaekers, J, Politis, C, Miserez, M, Galipienso Eri, M, Garcia Montesino, JD, Dellonder Frigole, J, Noriego Munoz, D, Lizzi, V, Vovola, F, Arminio, A, Cotoia, A, Sarni, AL, Bekheit, M, Kamera, BS, Elhusseini, M, Sharma, P, Ahmeidat, A, Gradinariu, G, Cymes, W, Hannah, A, Mignot, G, Shaikh, S, Agilinko, J, Sgro, A, Rashid, MM, Milne, K, McIntyre, J, Akhtar, MA, Turnbull, A, Brunt, A, Stewart, KE, Wilson, MSJ, Rutherford, D, McGivern, K, Massie, E, Duff, S, Moura, F, Brown, BC, Khan, A, Asaad, P, Wadham, B, Aneke, IA, Collis, J, Warburton, H, Thomas, M, Pearce, L, Fountain, DM, Laurente, R, Sigamoney, KV, Dasa, M, George, K, Naqui, Z, Galhoum, M, Lipede, C, Gabr, A, Radhakrishnan, A, Hasan, MT, Kalenderov, R, Pathmanaban, O, Colombo, F, Chelva, R, Subba, K, Abou-Foul, AK, Khalefa, M, Hossain, F, Moores, T, Pickering, L, Shah, J, Anthoney, J, Emmerson, O, Bevan, K, Makin-Taylor, R, Ong, CS, Callan, R, Bloom, O, Chauhan, G, Kaur, J, Burahee, A, Bleibleh, S, Pigadas, N, Snee, D, Bhasin, S, Crichton, A, Habeebullah, A, Bodla, AS, Yassin, N, Mondragon, M, Dewan, V, Giuffrida, MC, Marano, A, Palagi, S, Grimaldi, Di Maria S, Testa, V, Peluso, C, Borghi, F, Simonato, A, Puppo, A, D'Agruma, M, Chiarpenello, R, Pellegrino, L, Maione, F, Cianflocca, D, Pruiti, Ciarello V, Giraudo, G, Gelarda, E, Dalmasso, E, Abrate, A, Daniele, A, Ciriello, V, Rosato, F, Garnero, A, Leotta, L, Chiozza, M, Anania, G, Urbani, A, Radica, Koleva M, Carcoforo, P, Portinari, M, Sibilla, M, Archer, JE, Odeh, A, Siddaiah, N, Baumber, R, Parry, J, Carmichael, H, Velopulos, CG, Wright, FL, Urban, S, McIntyre, Jr RC, Schroeppel, TJ, Hennessy, EA, Dunn, J, Zier, L, Parmar, C, Mccluney, S, Shah, S, Munoz Vives, JM, Osorio, A, Gomez Diaz, CJ, Guariglia, CA, Soto Montesinos, C, Sanchon, L, Xicola Martinez, M, Guardia, N, Collera, P, Diaz Del Gobbo, R, Sanchez Jimenez, R, Farre Font, R, Flores Clotet, R, Brathwaite, CEM, Liu, H, Petrone, P, Hakmi, H, Sohail, AH, Baltazar, G, Heckburn, R, Aujayeb, A, Townshend, D, McLarty, N, Shenfine, A, Jackson, K, Johnson, C, Madhvani, K, Hampton, M, Hormis, AP, Young, R, Miu, V, Sheridan, K, MacDonald, L, Green, S, Onos, L, Dean, B, Luney, C, Myatt, R, Williams, MA, McVeigh, J, Alqallaf, A, Ben-Sassi, A, Mohamed, I, Mellor, K, Joshi, P, Joshi, Y, Crichton, R, Sonksen, J, Aldridge, K, Layton, GR, Karki, B, Jeong, H, Pankhania, S, Asher, S, Folorunso, A, Mistry, S, Singh, B, Winyard, J, Mangwani, J, Babu, BHB, Liyanage, ASD, Newman, S, Blake, I, Weerasinghe, C, Ballabio, M, Bisagni, P, Longhi, M, Armao, T, Madonini, M, Gagliano, A, Pizzini, P, Alga, A, Nordberg, M, Sandblom, G, Jallad, S, Lord, J, Anderson, C, El Kafsi, J, Logishetty, K, Saadya, A, Midha, R, Ip, M, Ponniah, Subbiah H, Stockdale, T, Bacarese-Hamilton, T, Foster, L, James, A, Anjarwalla, N, Henriques, Marujo D, Hettige, R, Baban, C, Tenovici, A, Salerno, G, Hardie, J, Page, S, Anazor, F, King, SD, Luck, J, Kazzaz, S, HKruijff, S, De Vries, JPPM, Steinkamp, PJ, Jonker, PKC, Van der Plas, WY, Bierman, W, Janssen, Y, Borgstein, ABJ, Gisbertz, SS, Henegouwen, van Berge MI, Enjuto, D, Perez Gonzalez, M, Diaz Pena, P, Gonzalez, J, Marqueta De Salas, M, Martinez Pascual, P, Rodriguez Gomez, L, Garces Garcia, R, Ramos Bonilla, A, Herrera-Merino, N, Fernandez Bernabe, P, Cagigal Ortega, EP, Hernandez, I, de Castro Rubio, Garcia E, Cervera, I, Kashora, F, Siddique, MH, Singh, A, Barmpagianni, C, Basgaran, A, Basha, A, Okechukwu, V, Bartsch, A, Gallagher, P, Maqsood, A, Sahnan, K, Leo, CA, Lewis, SE, Ubhi, HK, Exley, R, Khan, U, Shah, P, Saxena, S, Zafar, N, Abdul-Jabar, H, Mongelli, F, Bernasconi, M, Di Giuseppe, M, Christoforidis, D, La Regina, D, Arigoni, M, Liew, I, Al-Sukaini, A, Mediratta, S, Saxena, D, Brown, O, Boal, M, Dean, H, Higgs, S, Stanger, S, Abdalaziz, H, Constable, J, Ishii, H, Preece, R, Dovell, G, Reddy, Gopi R, Dehal, A, Shah, HB, Cross, GWV, Seyed-Safi, P, Smart, YW, Kuc, A, Al-Yaseen, M, Jayasankar, B, Balasubramaniam, D, Abdelsaid, K, Mundkur, N, Gallagher, B, Hine, T, Keeler, B, Soulsby, RE, Taylor, A, Davies, E, Ryska, O, Raymond, T, Rogers, S, Tong, A, Hawkin, P, Kinnaman, G, Meagher, A, Sharma, I, Holler, E, Dunning, J, Viswanath, Y, Freystaetter, K, Dixon, J, Hadfield, JN, Hilley, A, Egglestone, A, Smith, B, Arkani, S, Freedman, J, Youssef, M, Sreedharan, L, Baskaran, D, Shaikh, I, Seebah, K, Reid, J, Watts, D, Kouritas, V, Chrastek, D, Maryan, G, Gill, DF, Khatun, F, Ranjit, S, Parakh, J, Sarodaya, V, Daadipour, A, Khalifa, M, Bosch, KD, Bashkirova, V, Dvorkin, LS, Kalidindi, VK, Choudhry, A, Marx, W, Espino Segura-Illa, M, Sanchez Aniceto, G, Castano-Leon, AM, Jimenez-Roldan, L, Delgado Fernandez, J, Perez Nunez, A, Lagares, A, Garcia Perez, D, Santas, M, Paredes, I, Esteban Sinovas, O, Moreno-Gomez, L, Rubio, E, Vega, V, Vivas Lopez, A, Labalde Martinez, M, Garcia Villar, O, Pelaez Torres, PM, Garcia-Borda, J, Ferrero Herrero, E, Gomez, P, Eiriz Fernandez, C, Ojeda-Thies, C, Pardo Garcia, JM, Jones, Wynn H, Divecha, H, Whelton, C, Board, T, Hardie, C, Powell-Smith, E, Alotaibi, M, Maashi, A, Zowgar, A, Alsakkaf, M, Izquierdo, O, Ventura, D, Castellanos, J, Lara, A, Escobar, D, Arrieta, M, Garcia de Cortazar, U, Villamor Garcia, I, Cioci, A, Ruiz, G, Allen, M, Rakoczy, K, Pavlis, W, Saberi, R, Sobti, A, Khaleel, A, Unnithan, A, Memon, K, Bhaskar, Pala RR, Maqboul, F, Kamel, F, Al-Samaraee, A, Madani, R, Kumar, L, Nisar, P, Agrawal, S, Llaquet Bayo, H, Duchateau, N, De Gheldere, C, Cheng, D, Yang, H, Fayad, A, Wood, ML, Persad, A, Groot, G, Pham, H, Hakami, I, Boeker, C, Mall, J, Smith, H, Haugstvedt, AF, Jonsson, M, Caja Vivancos, P, Villalabeitia Ateca, I, Prieto Calvo, M, Martin Playa, P, Gainza, A, Aragon Achig, EJ, Rodriguez Fraga, A, Melchor Corcostegui, I, Mallabiabarrena Ormaechea, G, Garcia Gutierrez, JJ, Barbier, L, Pesantez Peralta, MA, Jimenez Jimenez, M, Municio Martin, JA, Gomez Suarez, J, Garcia Opere, G, Pascua Gomez, LA, Onate Aguirre, M, Fernandez-Colorado, A, De la Rosa-Estadella, M, Gasulla-Rodriguez, A, Serrano-Martin, M, Peig-Font, A, Junca-Marti, S, Juarez-Pomes, M, Garrido-Ondono, S, Blasco-Torres, L, Molina-Corbacho, M, Maldonado-Sotoca, Y, Gasset-Teixidor, A, Blasco-Moreu, J, Turrado-Rodriguez, V, Lacy, AM, de Lacy, FB, Morales, X, Carreras-Castaner, A, Torner, P, Jornet-Gibert, M, Balaguer-Castro, M, Renau-Cerrillo, M, Camacho-Carrasco, P, Vives-Barquiel, M, Campuzano-Bitterling, B, Gracia, I, Pujol-Muncunill, R, Estaire Gomez, M, Padilla-Valverde, D, Sanchez-Garcia, S, Sanchez-Pelaez, D, Jimenez Higuera, E, Picon Rodriguez, R, Fernandez Camunas, A, Martinez-Pinedo, C, Garcia Santos, EP, Munoz-Atienza, V, Moreno Perez, A, de la Manzanara Cano, Lopez CA, Crego-Vita, D, Huecas-Martinez, M, Domenech, J, Rosello Anon, A, Sanguesa, MJ, Bernal-Sprekelsen, JC, Catala Bauset, JC, Renovell Ferrer, P, Martinez 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HKruijff, S, De Vries, JPPM, Steinkamp, PJ, Jonker, PKC, Van der Plas, WY, Bierman, W, Janssen, Y, Borgstein, ABJ, Gisbertz, SS, Henegouwen, MIV, Enjuto, D, Gonzalez, MP, Pena, PD, Gonzalez, J, De Salas, MM, Pascual, PM, Gomez, LR, Garcia, RG, Bonilla, AR, Herrera-Merino, N, Bernabe, PF, Ortega, C, Hernandez, I, Rubio, EGD, Cervera, I, Kashora, F, Siddique, MH, Singh, A, Barmpagianni, C, Basgaran, A, Basha, A, Okechukwu, V, Bartsch, A, Gallagher, P, Maqsood, A, Sahnan, K, Leo, CA, Lewis, SE, Ubhi, HK, Exley, R, Khan, U, Shah, P, Saxena, S, Zafar, N, Abdul-Jabar, H, Mongelli, F, Bernasconi, M, Di Giuseppe, M, Christoforidis, D, La Regina, D, Arigoni, M, Liew, I, Al-Sukaini, A, Mediratta, S, Saxena, D, Brown, O, Boal, M, Dean, H, Higgs, S, Stanger, S, Abdalaziz, H, Constable, J, Ishii, H, Preece, R, Dovell, G, Reddy, RG, Dehal, A, Shah, HB, Cross, GWV, Seyed-Safi, P, Smart, YW, Kuc, A, Al-Yaseen, M, Jayasankar, B, Balasubramaniam, D, Abdelsaid, K, Mundkur, N, Gallagher, B, Hine, T, 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Lacy, FB, Morales, X, Carreras-Castaner, A, Torner, P, Jornet-Gibert, M, Balaguer-Castro, M, Renau-Cerrillo, M, Camacho-Carrasco, P, Vives-Barquiel, M, Campuzano-Bitterling, B, Gracia, I, Pujol-Muncunill, R, Gomez, ME, Padilla-Valverde, D, Sanchez-Garcia, S, Sanchez-Pelaez, D, Higuera, EJ, Rodriguez, RP, Camunas, AF, Martinez-Pinedo, C, Santos, EPG, Munoz-Atienza, V, Perez, AM, Cano, CALD, Crego-Vita, D, Huecas-Martinez, M, Domenech, J, Anon, AR, Sanguesa, MJ, Bernal-Sprekelsen, JC, Bauset, JCC, Ferrer, PR, Perez, CM, Gil-Albarova, O, Estelles, JG, Aghababyan, K, Rivas, R, Rivas, F, Escartin, J, Laina, JLB, Nogues, A, Cros, B, El-Abur, IT, Egea, JG, Yanez, C, Kauppila, JH, Sarjanoja, E, Tzedakis, S, Bouche, PA, Gaujoux, S, Gossot, D, Seguin-Givelet, A, Fuks, D, Grigoroiu, M, Salas, RS, Cathelineau, X, Macek, P, Barbe, Y, Rozet, F, Barret, E, Mombet, A, Cathala, N, Brian, E, Zadegan, F, Conso, C, Baldwin, AJ, West, R, Gammeri, E, Catton, A, Kouris, SM, Pereca, J, Singh, J, Patel, P, Handa, S, Kaushal, M, Kler, A, Reghuram, V, Tezas, S, Oktseloglou, V, Mosley, F, Monroy, MFID, Bobak, P, Omar, I, Ahad, S, Langlands, F, Brown, V, Hashem, M, Williams, A, Ridgway, A, Pournaras, D, Britton, E, Lostis, E, Ambler, GK, Chu, H, Hopkins, J, Manara, J, Chan, M, Doe, M, Moon, RDC, Jichi, T, Singleton, W, Mannion, R, Ramzi, J, Mohan, M, Singh, AA, Ashcroft, J, Baker, OJ, Coughlin, P, Davies, RJ, Durst, AZED, Abood, A, Habeeb, A, Hudson, VE, Lamb, B, Luke, L, Mitrasinovic, S, Murphy, S, Ngu, AWT, O'Neill, JR, Waseem, S, Wong, K, Georgiades, F, Hutchinson, PJ, Tan, XS, Pushpa-rajah, J, Colquhoun, A, Masterson, L, Abu-Nayla, I, Walker, C, Balakrishnan, A, Rooney, S, Irune, E, Byrne, MHV, Durrani, A, Richards, T, Venkatesan, AS, Combellack, T, Williams, J, Tahhan, G, Mohammed, M, Kornaszewska, M, Valtzoglou, V, Deglurkar, I, Rahman, M, Von Oppell, U, Mehta, D, Koutentakis, M, Chek, SAHSN, Hill, G, Morris, C, Shinkwin, M, Torkington, J, Cornish, J, Houston, R, Mannan, S, Ayeni, F, Tustin, H, Bordenave, M, Robson, A, Manu, N, Eardley, N, Krishnan, E, Serevina, OL, Martin, E, Smith, C, Jones, A, Mahapatra, SR, Clifford, R, Matthews, W, Mohankumar, K, Khawaja, I, Palepa, A, Doulias, T, Premakumar, Y, Jauhari, Y, Koshnow, Z, Bowen, D, Uberai, A, Hirri, F, Stubbs, BM, McDonald, C, Manickavasagam, J, Ragupathy, K, Davison, S, Dalgleish, S, McGrath, N, Kanitkar, R, Payne, CJ, Ramsay, L, Ng, CE, Collier, T, Khan, K, Evans, R, Brennan, C, Henshall, DE, Drake, T, Zamvar, V, Tambyraja, A, Skipworth, RJE, Linder, G, McGregor, R, Brennan, P, Mayes, J, Ross, L, Smith, S, White, T, Jamjoom, AAB, Pasricha, R, Holme, T, Abbott, S, Razik, A, Thrumurthy, S, Steinke, J, Baker, M, Howden, D, Baxter, Z, Osagie, L, Bence, M, Fowler, GE, Massey, L, Rajaretnam, N, Evans, J, John, J, Goubran, A, Campain, N, McDermott, FD, McGrath, JS, Ng, M, Pascoe, J, Phillips, JRA, Daniels, IR, Raptis, DA, Pollok, JM, Machairas, N, Davidson, B, Fusai, G, Soggiu, F, Xyda, S, Salinas, CH, Tzerbinis, H, Pissanou, T, Gilliland, J, Chowdhury, S, Varcada, M, Hart, C, Mirnezami, R, Knowles, J, Angamuthu, N, Vijay, V, Shakir, T, Hasan, R, Tansey, R, Ross, E, Loubani, M, Wilkins, A, Cao, H, Capitelli-McMahon, H, Hitchman, L, Ikram, H, Andronic, A, Ibrahim, AA, Totty, J, Tayeh, S, Chase, T, Humphreys, L, Ayorinde, J, Ghanbari, A, Cuming, T, Williams, K, Chung, E, Hagger, R, Karim, A, Hainsworth, A, Flatman, M, Trompeter, A, Hing, C, Tsinaslanidis, P, Benjamin, MW, Leyte, A, Tan, C, Smelt, J, Vaughan, P, Santhirakumaran, G, Hunt, I, Raza, M, Labib, A, Luo, X, Sudarsanam, A, Rolls, A, Lyons, O, Onida, S, Shalhoub, J, Sugand, K, Park, C, Sarraf, KM, Erridge, S, Kinross, J, Denning, M, Yalamanchili, S, Abuown, A, Ibrahim, M, Martin, G, Davenport, D, Wheatstone, S, Andreani, S, Bath, MF, Sahni, A, Judkins, N, Springford, LR, Sohrabi, C, Bacarese-Hamilton, J, Taylor, FG, Patki, P, Tanabalan, C, Reynolds, J, Alexander, ME, Smart, CJ, Stylianides, N, Abdalla, M, Newton, K, Bhatia, K, Edmondson, R, Abdeh, L, Jones, D, Zeiton, M, Ismail, O, Naseem, H, Advani, R, Fell, A, Smith, A, Nikolaou, S, English, C, Kristinsson, S, Oni, T, Ilahi, N, Ballantyne, K, Woodward, Z, Merh, R, Robertson-Smith, B, Mahmoud, A, Ameerally, P, Finch, JG, Gnanachandran, C, Pop, I, Rogers, M, Yousef, Y, Woods, R, Zahid, H, Mundy, G, Dass, D, Ford, D, Khan, J, Thiruchandran, G, Toh, SKC, Ahmad, Y, Allana, A, Bellis, C, Babawale, O, Phan, YC, Lokman, U, Ismail, M, Koc, T, Witek, A, Duggleby, L, Shamoon, S, Stefan, S, Clancy, H, Singh, S, Mukherjee, S, Ferguson, D, Mansuri, A, Thakrar, A, Wickramarachchi, L, Cuthbert, R, Sivayoganathan, S, Chui, K, Karam, E, Dott, C, Singh, R, Lane, J, Colvin, HV, Badran, A, Cadersa, A, Cumpstey, A, Hamady, Z, Aftab, R, Wensley, F, Byrne, J, Morrison-Jones, V, Sekhon, GK, Shields, H, Shakoor, Z, Yener, A, Talbot, T, Alzetani, A, Cresner, R, Johnson, D, Hughes, I, Hall, J, Rooney, J, Chatterji, S, Zhang, Y, Owen, R, Rudic, M, Hunt, J, Zakai, D, Aladeojebi, A, Ali, M, Gaunt, A, Barmayehvar, B, Kitchen, M, Gowda, M, Mansour, F, Jarvis, M, Halliday, E, Lefroy, R, Nanjaiah, P, Ali, S, Lin, DJ, Rajgor, AD, Scurrah, RJ, Kang, C, Watson, LJ, Harris, G, Royle, T, Cunningham, Y, James, G, Steel, B, Luk, ACO, Stables, G, Doorgakant, A, Thiruvasagam, VG, Carter, J, Reid, S, Mohammed, R, Marlow, W, Ferguson, H, Wilkin, R, Konstantinou, C, Yershov, D, Vatish, J, Denning, A, Das, R, Powell, S, Magee, C, Agarwal, K, Mangos, E, Nambirajan, T, Flindall, I, Mahendran, V, Hanson, A, De Marchi, J, Hill, A, Farrell, T, Davis, NF, Kearney, D, Nelson, T, Picciariello, A, Papagni, V, Altomare, DF, Granieri, S, Cotsoglou, C, Cabeleira, A, Branco, C, Serralheiro, P, Alves, R, Teles, T, Lazaro, A, Canhoto, C, Simoes, J, Costa, M, Almeida, AC, Nogueira, O, Oliveira, A, Nemesio, RA, Silva, M, Lopes, C, Amaral, MJ, da Costa, AV, Andrade, R, Martins, R, Guimaraes, A, Guerreiro, P, Ruivo, A, Camacho, C, Duque, M, Santos, E, Breda, D, Oliveira, JM, Lopez, ALD, Garrido, S, Colino, M, De Barros, J, Correia, S, Rodrigues, M, Cardoso, P, Teixeira, J, Soares, AP, Morais, H, Pereira, R, Revez, T, Manso, MI, Domingues, JC, Henriques, P, Ribeiro, R, Ribeiro, VI, Cardoso, N, Sousa, S, dos Santos, SM, Miranda, P, Garrido, R, Ferreira, MP, Ascensao, J, Costeira, B, Cunha, C, Rodrigues, LR, Fernandes, MS, Azevedo, P, Ribeiro, J, Lourenco, I, Gomes, H, Mendinhos, G, Pinto, AN, dos Santos, GM, Taflin, H, Abdou, H, Diaz, J, Richmond, M, Clark, J, O'Meara, L, Hanna, N, Cooper, Z, Salim, A, Hirji, SA, Brown, A, Chung, C, Hansen, L, Okafor, BU, Roxo, V, Raut, CP, Jolissaint, JS, Mahvi, DA, Reinke, C, Ross, S, Thompson, K, Manning, D, Perkins, R, Volpe, A, Merola, S, Ssentongo, A, Ssentongo, P, Oh, JS, Hazelton, J, Maines, J, Gusani, N, Garner, M, Horvath, S, Martin, RCG, Bhutiani, N, Choron, R, Peck, G, Soliman, F, Rehman, S, Abbas, A, Soliman, A, Kim, B, Jones, C, Dauer, MDE, Renza-Stingone, E, Hernandez, E, Gokcen, E, Kropf, E, Sufrin, H, Hirsch, H, Ross, H, Engel, J, Sewards, J, Poggio, J, Sanserino, K, Rae, L, Philp, M, Metro, M, McNelis, P, Petrov, R, Pazionis, T, Quintana, M, Jackson, H, Lumenta, DB, Nischwitz, SP, Richtig, E, Pau, M, Srekl-Filzmaier, P, Eibinger, N, Michelitsch, B, Fediuk, M, Papinutti, A, Seidel, G, Kahn, J, Cohnert, TU, Kantor, E, Kahiu, J, Hossain, N, Hosny, S, Sultana, A, Taggarsi, M, Vitone, L, Lambert, J, Vaz, OP, Sarantitis, I, Shrestha, D, Timbrell, S, Shugaba, A, Jones, GP, Gardner, A, Tripathi, SS, Greenhalgh, MS, Emerson, H, Vejsbjerg, K, McCormick, W, Fisher, A, Singisetti, K, Aawsaj, Y, Barry, C, Blanco, J, Vanker, R, Ghobrial, M, Jones, G, Kanthasamy, S, Fawi, H, Awadallah, M, Chen, F, Cheung, J, Tingle, S, Abbadessa, F, Sachdeva, A, Rai, B, Chan, CD, McPherson, I, Booth, K, Ali, FM, Pandanaboyana, S, Grainger, T, Nandhra, S, Patience, A, Rogers, A, Roy, C, Williams, T, Dawe, N, McCaffer, C, Riches, J, Bhattacharya, S, Moir, J, Kalson, NS, Ahmed, HE, Mellor, C, Saleh, C, Koshy, RM, Hammond, J, Sanderson, L, Wahed, S, Phillips, AW, Ghosh, K, Rogers, LJ, Labib, PL, Miller, D, Minto, G, Hope, N, Marchbank, A, Emslie, K, Panahi, P, Ho, B, Perkins, C, Clough, E, Roy, H, Enemosah, I, Campbell, R, Natale, J, Gohil, K, Rela, M, Raza, N, Menakaya, C, Webb, JI, Antar, M, Modi, N, Sofat, R, Noel, J, Nunn, R, Adegbola, S, Eriberto, F, Sharma, V, Tanna, R, Lodhia, S, Carvalho, L, Osorio, C, Antunes, J, Lourenco, S, Balau, P, Godinho, M, Pereira, A, Keller, DS, Smart, NJ, Apollo - University of Cambridge Repository, Collaborative, COVIDSurg, and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
Subjects: Male, medicine.medical_specialty, Multivariate analysis, MORTALITY-RATES, hip, SURGERY, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MULTICENTER, COVIDSurg Collaborative, 1117 Public Health and Health Services, Cohort Studies, Medicine, General & Internal, Internal medicine, General & Internal Medicine, medicine, Dementia, Humans, Prospective Studies, Aged, 80 and over, COMPLICATIONS, Science & Technology, HIP-FRACTURES, business.industry, Hip Fractures, SARS-CoV-2, COVID-19, 1103 Clinical Sciences, General Medicine, Femoral fracture, Perioperative, medicine.disease, Heart failure, trauma management, Medicine, Surgery, business, Life Sciences & Biomedicine, Femoral Fractures, Kidney disease, Cohort study, 1199 Other Medical and Health Sciences
Abstract: ObjectivesStudies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
Published: 2021

44. Cytomegalovirus anterior uveitis in consecutive eyes with hypertensive uveitis: a tertiary care centre experience

Author: Vincent W Lam, Alexander J. Kaplan, Jason M Kwok, Ramzi Fattouh, Larissa Derzko-Dzulynsky, and Nupura Bakshi
Subjects: medicine.medical_specialty, business.industry, Congenital cytomegalovirus infection, MEDLINE, Cytomegalovirus, General Medicine, medicine.disease, Uveitis, Anterior, Tertiary care, Tertiary Care Centers, Uveitis, Ophthalmology, medicine, Humans, Anterior uveitis, business, Retrospective Studies
Published: 2021
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45. Clinical Presentation of Mandibular Impacted Teeth and Associated Pathologies in the Unaizah, Al Qaseem; Saudi Arabia

Author: Abdul Bari Memon, Abdul Hayee Shaikh, Ram Pershad, Khaled Ramzi Shora, Irfan Ahmed Shaikh, Mahnoor Memon, Bhavesh Maheshwari, and Kashif Ali Channar
Subjects: Molar, Impaction, business.industry, Impacted tooth, Cross-sectional study, Medical record, Dentistry, medicine.disease, Mandibular second molar, stomatognathic system, Oral and maxillofacial surgery, Medicine, Pericoronitis, business
Abstract: Aim: The aim of this study was to evaluate the clinical presentation of mandibular impacted teeth and associated pathologies in Unaizah, Al Qaseem; Saudi Arabia. Study Design: Descriptive cross sectional study. Place and Duration of Study: Department of Oral and Maxillofacial Surgery (OMFS), King Saud Hospital Unaizah Saudi Arabia from March 2019 and December 2020. Methodology: The record of patients attending dental section was reviewed from hospital record. Demographic data of patients were recorded through medical record Number by Medicapluse software. Orthopantamograms (OPGs) xrays were reviewed by maxillofacial surgeons on Dell LCD using software IMPEX 6.3.1.2794 enterprise unlimited Agfa. The variables like presence of impacted tooth, type of angulations, reason for extraction, caries on distal surface of 2nd molar tooth, and occlusal or mesial surface of 3rd molar were examined on OPGs. Data was analyzed using SPSS version-21. Results: Males and females were 49% and 51% respectively. The most common type of impaction was vertical 45%, followed by horizontal 27% and mesio angular 22%. The impacted tooth on right side was observed as 51% and on left side as 49%. The relationship of gender with type of impaction was statistically insignificant (p value-0.157). The relationship was reasons and type of impaction was statistically insignificant (p value-0.317) Conclusion: the both genders were almost equally affected. Vertical Impactions were more frequent and the pericoronitis was common reason for extraction of mandibular third molar. The relationship of gender and type of impaction was not significantly associated with type of impaction.
Published: 2021
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46. Selinexor in Combination with R-CHOP for Frontline Treatment of Non-Hodgkin Lymphoma: Results of a Phase I Study

Author: Amro Aboukameel, Asfar S. Azmi, Erlene K. Seymour, Divaya Bhutani, Jeffrey A. Zonder, Kathy A. Reichel, Jatin P. Shah, Ramzi M. Mohammad, Colleen Neveux, Silvana Pregja, Husain Yar Khan, Yiwei Li, Amy Huddlestun, Sharon Shacham, Kelly Corona, Irfana Muqbil, Mahmoud Chaker, Michael Kauffman, Golbon Sterbis, Christiane Houde, Yosef Landesman, Radhakrishanan Ramchandren, and Jay Yang
Subjects: Oncology, Cancer Research, Vincristine, medicine.medical_specialty, Chemotherapy, Cyclophosphamide, business.industry, medicine.medical_treatment, medicine.disease, Lymphoma, 03 medical and health sciences, 0302 clinical medicine, Maintenance therapy, Tolerability, 030220 oncology & carcinogenesis, Internal medicine, medicine, Rituximab, Doxorubicin, business, 030215 immunology, medicine.drug
Abstract: Purpose: The nuclear exporter protein exportin-1 (XPO1) is overexpressed in non-Hodgkin lymphoma (NHL) and correlates with poor prognosis. We evaluated enhancing R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) activity in NHL by targeted inhibition of XPO1 using the selective inhibitor of nuclear export (SINE) compounds. Patients and Methods: We evaluated the antitumor activity of SINE compounds in combination with CHO chemotherapy in vitro and in vivo. Newly diagnosed NHL patients in a phase I dose-escalation study received R-CHOP for 6 cycles with weekly selinexor (60, 80, and 100 mg), then selinexor maintenance therapy for one year. RT-PCR, Western blotting, and RNA sequencing were performed on patient blood samples. Results: SINE compounds synergized with CHO in vitro in NHL cell lines and in vivo in our murine xenograft model. In our phase I study, selinexor was dosed at 60 mg (n = 6) and 80 mg (n = 6). The most common adverse events (AE) among 12 patients were fatigue (67%) and nausea (100%). Grade 3–4 AEs were infrequent. Ten evaluable patients had an overall response rate of 100% and complete remission rate of 90% with sustained remissions (median follow-up: 476 days). Maximally tolerated dose was not reached; however, the recommended phase II dose was 60 mg selinexor weekly after evaluating tolerability and discontinuation rates for each dose cohort. Analysis of patient blood samples revealed downregulation of XPO1 and several prosurvival markers. Conclusions: SINE compounds enhance the activity of CHO in vitro and in vivo. Selinexor in combination with R-CHOP was generally well tolerated and showed encouraging efficacy in NHL (NCT03147885).
Published: 2021
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47. Estimated glucose disposal rate as a candidate biomarker for thrombotic biomarkers in T1D: a pooled analysis

Author: Sam Pearson, Noppadol Kietsiriroje, Ramzi A. Ajjan, Melvin Holmes, Daniel J. West, Lauren L. O’Mahoney, and Matthew Campbell
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Platelet Aggregation, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Fibrinogen, Risk Assessment, Gastroenterology, Body Mass Index, Thromboplastin, 03 medical and health sciences, Cluster analysis, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, Diabetes mellitus, Plasminogen Activator Inhibitor 1, medicine, Humans, Insulin, eGDR, Blood Coagulation, Glycated Hemoglobin, Type 1 diabetes, business.industry, Thrombosis, medicine.disease, Diabetes Mellitus, Type 1, Blood pressure, Biomarker (medicine), Original Article, Female, Insulin Resistance, business, Biomarkers, medicine.drug
Abstract: Purpose To determine the utility of estimated glucose disposal rate (eGDR) as a candidate biomarker for thrombotic biomarkers in patients with type 1 diabetes (T1D). Methods We reanalysed baseline pretreatment data in a subset of patients with T1D from two previous RCTs, consisting of a panel of thrombotic markers, including fibrinogen, tissue factor (TF) activity, and plasminogen-activator inhibitor (PAI)-1, and TNFα, and clinical factors (age, T1D duration, HbA1c, insulin requirements, BMI, blood pressure, and eGDR). We employed univariate linear regression models to investigate associations between clinical parameters and eGDR with thrombotic biomarkers. Results Thirty-two patients were included [mean ± SD age 31 ± 7 years, HbA1c of 58 ± 9 mmol/mol (7.5 ± 0.8%), eGDR 7.73 ± 2.61]. eGDR negatively associated with fibrinogen (P P = 0.005), and TF activity (P = 0.020), but not TNFα levels (P = 0.881). We identified 2 clusters of patients displaying significantly different characteristics; 56% (n = 18) were categorised as ‘higher-risk’, eliciting significantly higher fibrinogen (+ 1514 ± 594 μg/mL; P P P P P P 2; P P Conclusions Compared to BMI and insulin requirements, classical surrogates of insulin resistance, eGDR is a suitable and superior thrombotic risk indicator in T1D. Trial registration ISRCTN4081115; registered 27 June 2017.
Published: 2021
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48. Tip-to-Base LAMPOON for Transcatheter Mitral Valve Replacement With a Protected Mitral Annulus

Author: Brian Whisenant, Pradeep Yadav, Gaetano Paone, Paul Mahoney, James M. McCabe, Jaffar M. Khan, John Lisko, Jose F. Condado, Adam Greenbaum, Norihiko Kamioka, Ramzi Khalil, Jasleen Tiwana, Patrick Gleason, Toby Rogers, Neal S. Kleiman, Michael J. Reardon, Sachin S. Goel, Kendra J. Grubb, Krishna Cherukuri, Robert J. Lederman, David Lasorda, Rachel Koch, Vasilis Babaliaros, Brian C. Case, David V. Daniels, Christopher G Bruce, Christian Spies, and Isida Byku
Subjects: Aortic valve, Cardiac Catheterization, medicine.medical_specialty, medicine.medical_treatment, Ventricular outflow tract obstruction, Investigational device exemption, 030204 cardiovascular system & hematology, Prosthesis, Article, Ventricular Outflow Obstruction, 03 medical and health sciences, 0302 clinical medicine, Aortic valve replacement, Valve replacement, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Retrospective Studies, Heart Valve Prosthesis Implantation, Mitral regurgitation, business.industry, Mitral valve replacement, Mitral Valve Insufficiency, medicine.disease, Surgery, Treatment Outcome, medicine.anatomical_structure, Heart Valve Prosthesis, cardiovascular system, Mitral Valve, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Objectives The purpose of this study was to evaluate tip-to-base intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction (LAMPOON) in patients undergoing transcatheter mitral valve replacement (TMVR) in annuloplasty rings or surgical mitral valves. Background LAMPOON is an effective adjunct to TMVR that prevents left ventricular outflow tract obstruction (LVOTO). Laceration is typically performed from the base to the tip of the anterior mitral leaflet. A modified laceration technique from leaflet tip to base may be effective in patients with a prosthesis that protects the aortomitral curtain. Methods This is a multicenter, 21-patient, consecutive retrospective observational cohort. Patients underwent tip-to-base LAMPOON to prevent LVOTO and leaflet overhang, or therapeutically to lacerate a long anterior mitral leaflet risking or causing LVOTO. Outcomes were compared with findings from patients in the LAMPOON investigational device exemption trial with a prior mitral annuloplasty. Results Twenty-one patients with a annuloplasty or valve prosthesis–protected mitral annulus underwent tip-to-base LAMPOON (19 preventive, 2 rescue). Leaflet laceration was successful in all and successfully prevented or treated LVOTO in all patients. No patients had significant LVOTO upon discharge. There were 2 cases of unintentional aortic valve injury (1 patient underwent emergency transcatheter aortic valve replacement and 1 patient underwent urgent surgical aortic valve replacement). In both cases, the patients had a supra-annular ring annuloplasty, and the retrograde aortic guiding catheter failed to insulate the guidewire lacerating surface from the aortic root. All patients survived to 30 days. Compared with classic retrograde LAMPOON, there was a trend toward shorter procedure time. Conclusions Tip-to-base laceration is a simple, effective, and safe LAMPOON variant applicable to patients with an appropriately positioned mitral annular ring or bioprosthetic valve. Operators should take care to insulate the lacerating surface from adjacent structures.
Published: 2021
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49. Antegrade Scrotal Sclerotherapy of Internal Spermatic Veins for Varicocele Treatment: Results and Complications about 660 Cases

Author: Jasser Maatougui, Raboudi Mehdi, Mohamed amine Bakir, Tarek Taktak, Ben Rejeb Nadhir, Ramzi Khiari, and Samir Ghozzi
Subjects: medicine.medical_specialty, Testicular atrophy, business.industry, medicine.medical_treatment, Varicocele, medicine.disease, Surgery, Male infertility, Oligospermia, Hydrocele, medicine, Sclerotherapy, Orchitis, business, Scrotal Pain
Abstract: Introduction: Varicocele is one of the leading causes of male infertility. Anterograde scrotal sclerotherapy (ASS) is one of the most recent techniques. Our objective is to evaluate the results of ASS in the treatment of varicocele in adults. Methods: This is a descriptive and analytical study of 660 patients treated for varicocele causing either a picture of hypofertility and/or symptomatic during the period from January 2008 to December 2018. Preoperative, intraoperative and postoperative data were analysed. Results: The average age was 30. The average duration of the intervention was 16 minutes (13-50 mins) and the average length of hospitalization was 19 hours (9-36 hours). We noticed a statistically significant improvement in all characteristics on the postoperative spermogram. Oligospermia increased from 41% to 29% (p=0.01), asthenospermia increased from 52% to 33% (p=0.02) and teretospermia from 24% to 14% (p=0.006). The paternity rate among hypofertile men was 22%. The disappearance of varicocele in postoperative was objectified in 588 patients (84%), the disappearance of scrotal pain in 322 patients (48%). Complications were identified in 70 patients (10.6%) hydrocele (27 patients, 4%), scrotal hematoma (14 patients), chemical orchitis (20 patients) and testicular atrophy (9 patients). A recurrence was noted in 73 patients (11%) at 9 months. Conclusion: SSA appears to be a reliable and reproducible technique in the treatment of varicocele, with significantly less morbidity in comparison with other techniques. We recommend it as a first-line treatment.
Published: 2021
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50. Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice

Author: Tim Esbenshade, Martin D. Brand, Ramzi F. Sweis, Simon Melov, Vojtech Mezera, Bryan McKibben, Pratiksha A. Dighe, Marina A. Pliushchev, Akos A. Gerencser, Zhi Wang, Stephan Riedmaier, and Hoi Shan Wong
Subjects: 0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, Reactive oxygen species, biology, Superoxide, Succinate dehydrogenase, SOD2, Mitochondrion, medicine.disease, Biochemistry, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Endocrinology, chemistry, In vivo, Physiology (medical), Internal medicine, medicine, biology.protein, Steatosis, 030217 neurology & neurosurgery
Abstract: Superoxide produced by mitochondria has been implicated in numerous physiologies and pathologies. Eleven different mitochondrial sites that can produce superoxide and/or hydrogen peroxide (O2.-/H2O2) have been identified in vitro, but little is known about their contributions in vivo. We introduce novel variants of S1QELs and S3QELs (small molecules that suppress O2.-/H2O2 production specifically from mitochondrial sites IQ and IIIQo, respectively, without compromising bioenergetics), that are suitable for use in vivo. When administered by intraperitoneal injection, they achieve total tissue concentrations exceeding those that are effective in vitro. We use them to study the engagement of sites IQ and IIIQo in mice lacking functional manganese-superoxide dismutase (SOD2). Lack of SOD2 is expected to elevate superoxide levels in the mitochondrial matrix, and leads to severe pathologies and death about 8 days after birth. Compared to littermate wild-type mice, 6-day-old Sod2-/- mice had significantly lower body weight, lower heart succinate dehydrogenase activity, and greater hepatic lipid accumulation. These pathologies were ameliorated by treatment with a SOD/catalase mimetic, EUK189, confirming previous observations. A 3-day treatment with S1QEL352 decreased the inactivation of cardiac succinate dehydrogenase and hepatic steatosis in Sod2-/- mice. S1QEL712, which has a distinct chemical structure, also decreased hepatic steatosis, confirming that O2.- derived specifically from mitochondrial site IQ is a significant driver of hepatic steatosis in Sod2-/- mice. These findings also demonstrate the ability of these new S1QELs to suppress O2.- production in the mitochondrial matrix in vivo. In contrast, suppressing site IIIQo using S3QEL941 did not protect, suggesting that site IIIQo does not contribute significantly to mitochondrial O2.- production in the hearts or livers of Sod2-/- mice. We conclude that the novel S1QELs are effective in vivo, and that site IQ runs in vivo and is a significant driver of pathology in Sod2-/- mice.
Published: 2021
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