1. Retinal Nerve Fiber Layer Thickness Correlates with Serum and Cerebrospinal Fluid Neurofilament Levels and is Associated with Current Disability in Multiple Sclerosis
- Author
-
Suzan Guven Yilmaz, Filiz Afrashi, Cihat Uzunköprü, Özgül Ekmekci, Nur Yüceyar, and Dilek Taskiran
- Subjects
medicine.medical_specialty ,Nerve fiber layer ,neurofilaments ,Multiple sclerosis ,chemistry.chemical_compound ,Cerebrospinal fluid ,peripapillary retinal nerve fiber layer (pRNFL) ,Ophthalmology ,PEG ratio ,medicine ,nitrotyrosine ,Expanded Disability Status Scale ,business.industry ,General Neuroscience ,biomarkers ,Retinal ,medicine.disease ,Psychiatry and Mental health ,medicine.anatomical_structure ,Multiple sclerosis functional composite ,chemistry ,optic coherence tomography (OCT) ,Biomarker (medicine) ,Optical Coherence Tomography ,Atrophy ,business ,Research Article - Abstract
Introduction: The main purpose of the present study is to confirm Peripapillary Retinal Nerve Fiber Layer (pRNFL) thickness is a biomarker of axonal degeneration in patients with Multiple Sclerosis (MS) and to evaluate its relationship with Neurofilament heavy chain (NfH) and Nitrotyrosine (NT). Method: We quantified serum (s) and/or cerebrospinal fluid (CSF) NfH and NT levels in 30 relapsing-remitting MS patients (RRMS), 16 secondary progressive MS (SPMS) patients and in 29 control subjects matched for age and gender. Optical coherence tomography (OCT) measurements of pRNFL were performed in all subjects. Clinical outcomes were tested by Multiple Sclerosis Functional Composite (MSFC) and Expanded Disability Status Scale (EDSS). Results: RRMS patients exhibited significantly higher NfH/NT levels (99 pg/mL, 107.52 nM respectively) than controls (74 pg/mL, 48.72 nM) in CSF (p, Scientific Research Found of Ege University School of Medicine [12-TIP-003], This study was supported by the Scientific Research Found of Ege University School of Medicine (12-TIP-003).
- Published
- 2021