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Background: In Peru a previous study of government-sponsored periodic examinations of female sex workers (FSWs) found no significant impact on rates of sexually transmitted diseases (STDs). Goal: This study assessed the impact of technically improved periodic STD services on STD prevalence and on consistent condom use (CCU). Study Design: The study involved monthly follow-up of 917 FSWs at two STD clinics with evaluations before and during implementation of strengthened STD services which included periodic screening and treatment for gonorrhea chlamydial infection trichomoniasis bacterial vaginosis (BV) and syphilis; counseling; and supply of condoms. Outcome analyses were adjusted for participation bias. Results: During 7908 person-months of observation the prevalences of gonorrhea chlamydial infection trichomoniasis and BV declined significantly and CCU increased significantly with similar trends in both clinics. During follow-up gonorrhea chlamydial infection trichomoniasis and BV were negatively associated with follow-up after screening. BV also was positively associated with use of an intrauterine device and negatively with douching. CCU during follow- up was associated with significantly decreased risk of gonorrhea chlamydial infection and trichomoniasis. Conclusions: Strengthened periodic screening for and treatment of confirmed STD in addition to condom promotion and provision represent feasible effective interventions in commercial sex and time series analyses can provide a useful approach to evaluating new interventions. (authors)

Human T cell lymphotropic virus type I (HTLV-I) is sexually transmitted. The purpose of this study was to determine the prevalence and risk factors for cervical shedding of HTLV-I DNA among Peruvian sex workers. HTLV tax DNA was detected in cervical specimens from 43 (68%) of 63 HTLV-I-infected sex workers and in samples obtained during 113 (52%) of 216 clinic visits between 1993 and 1997. Detection of HTLV DNA was associated with the presence of > or =30 polymorphonuclear cells (PMNs) within cervical mucus per 100x microscopic field (odds ratio [OR], 4.3, 95% confidence interval [CI], 1.8-10.1) and with the presence of cervical secretions (OR, 2.0; 95% CI 1.2-3.4). Hormonal contraceptive use (OR 1.7; 95% CI, 0.8-3.6) and concomitant cervical infection by Chlamydia trachomatis (OR, 1.5; 95% CI, 0.3-4.3) or Neisseria gonorrhoeae (OR, 1.1; 95% CI, 0.6-3.7) were not significantly associated with HTLV-I shedding. Our results suggest that cervicitis may increase cervical HTLV-I shedding and the sexual transmission of this virus.

Objectives: To determine age-specific seroprevalence, risk factors, and risk markers for heterosexually-acquired HIV infection among pregnant women. Design: Cross-sectional study of 12 436 consecutive pregnant women in Lima, Peru in 1996-1997. Methods: Standardized interviews, serologic tests for HIV and syphilis, bivariate and multivariate analysis. Results: HIV seropositivity was confirmed in 58 women (0.5%). Only 22.6% were married, and only 12% of HIV infected women reported ≥2 sex partners ever. In multivariate analyses HIV infection was associated with: short duration of current relationship; two risk behaviors of women themselves (early onset of sexual activity and number of past sexual relationships); women's perceptions of two risk behaviors of partners (partner is a 'womanizer,' and partner uses illegal drugs); inadequate prenatal care; and four additional risk factors or markers (history of sexually transmitted disease, tuberculosis, or abortion in the women; and diagnosis of HIV/AIDS in a partner). Conclusions: HIV infection was related both to women's own risk behaviors and to the perceived risk behaviors of their sexual partners. Underlying societal factors related to heterosexual HIV infection, including deferral of marriage, warrant further study.

Introduction We report an incidental finding of a 9.8 cm Crawford type III thoraco-abdominal aortic aneurysm associated with autosomal dominant polycystic kidney disease (ADPKD). Case report CT imaging revealed a grossly enlarged polycystic liver and right kidney in a 54-year-old female. The patient had a complex medical history including end-stage renal failure requiring haemodialysis and chronic obstructive pulmonary disease. She had experienced back pain for eighteen months. This was attributed to a progression of pain secondary to abdominal polycystic disease and therefore not investigated. She had previously undergone a left nephrectomy. A single-stage hybrid approach with open retrograde visceral re-vascularisation and endovascular stenting was carried out successfully to treat the aneurysm. Discussion We report this case to highlight the association between aortic aneurysms and ADPKD, and we present a solution to the complex technical problem involved.