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Adenoid cystic carcinoma (ACC) is an intriguing lesion because it shows a slow growth in the beginning, but a late poor prognosis due to perineural invasion, metastasis and recurrence. This study aimed to investigate whether Akt signaling would be deregulated in adenoid cystic carcinoma and its consequence in the expression of associated proteins. The expression of the Akt, p-Akt, NFκB, β-catenin, cyclin D1 and COX-2 was assessed by immunohistochemistry in 10 cases of ACC, 17 cases of pleomorphic adenoma (PA), and 7 cases of normal salivary gland (NSG). p-Akt was overexpressed in ACC when compared to NSG. NFκB, β-catenin, and COX-2 were overexpressed in ACC and PA when compared to NSG. Most proteins were slightly higher expressed in ACC than in PA, but they never reached significance. p-Akt expression positively correlated with NFκB, β-catenin, cyclin D1 and COX-2 in ACC and PA, while this correlation trended to be negative in for these proteins (except for NFκB) in NSG using Person’s correlation analysis, but without reaching significance. Our results indicate an abnormal activation of Akt signaling pathway, which can be an important regulator of tumor biology in ACC. Activated Akt correlated with the expression of NFκB, β-catenin and COX-2, which can potentially influence cell survival in ACC.

São descritos dois casos de zigomicose nasofacial, procedentes de Belém, PA. O achado indica não ser tão rara, como se poderia supor, pela falta de registros, a ocorrência dessa micose na Região Norte do Brasil. Em ambos os pacientes, o tratamento pelo cetoconazol determinou involução rápida das manifestações clínicas, principalmente a obstrução nasal. Com o presente relato, sobe para cinco o número de casos da infecção referidos até agora do Estado do Pará.

Hospital Adventista de Bel?m. Bel?m, PA, Brasil. Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil. Universidade de Bras?lia. Bras?lia, D F, Brasil.

É descrito um caso fatal de infecção por Lagochilascaris sp., — provavelmente Lagochilascaris minor Leiper, 1909 —, com localização pulmonar. O paciente, do sexo feminino, oriundo de Curralinho-Estado do Pará, desenvolveu uma pneumonite grave, que lhe acarretou a morte, por insuficiência respiratória, em pouco menos de três meses. À autópsia, numerosas lesões de natureza exsudativa e granulomatosa podiam ser vistas em ambos os pulmões, indicando tuberculose ou infecção micótica pulmonar. Todavia, quando se procedeu ao exame microscópico, ovos, larvas e até uma fêmea grávida do verme foram encontrados nos tecidos, como causa da doença — sempre no interior de granulomas ou de extensas áreas de necrose. Em quase todos os casos, até agora conhecidos, de lagoquilascaríase humana — cerca de 25 —, o parasito se localizava nos tecidos do pescoço, nos seios da face ou sobre a apófise mastóide. Neste caso, pela primeira vez, um representante do gênero Lagochilascaris é referido em sítio bem distinto do habitual, no hospedeiro humano. O achado, por outro lado, dos diferentes estádios evolutivos do helminto, dispersos pelo parênquima pulmonar, além de mostrar a natureza errática do parasitismo, sugere fortemente a existência de um ciclo pulmonar na lagoquilascaríase humana. A fatal case of pulmonary infection with Lagochilascaris sp. — probably Lagochilascaris minor — is presented. A 18-year-old girl from Curralinho — State of Para developed a severe pneumonitis of unknown origin, and died less than three months after the onset of the illness, She was admitted to the Hospital, in Belem-Pará, on 16 June 1983, with fever, productive cough, dyspnea and, eventually, cyanosis. At that time, she had been sick for at least four or five weeks. A chest X-ray film taken shortly after admission disclosed extensive bilateral infiltrates, predominantly on the right lung. Acid-fast bacilli and fungi, however, could not be demonstrated in the sputum. The leucocyte count was low (3.900), with 60% neutrophils and 40% lymphocytes. In spite of several therapeutic schedules (no definite cause for the disease could be found) the patient's condition rapidly deteriorated. She persisted with fever, cough, expectoration of thick sputum, dyspnea and cyanosis, but other symptoms also came forth: hoarseness, fatigue, weight loss and labored breathing. On 13 July she developed respiratory insufficiency and died. At autopsy, the lungs appeared distended with numerous areas of consolidation; the cut surface, when exposed, revealed disseminated foci, both nodular and diffuse, of granulomatous and exsudative inflammation. Microscopically, sections of eggs and round worms were found in the preparations, always surrounded by granulomas or large areas of necrotic tissue. The worms were recognized as evolutive stages — larvae, adult males and a gravid female — of a nematode belonging to the genus Lagochilascaris, probably Lagochilascaris minor. The identification was based, mainly, on the aspect of the eggs, which exhibited the irregular-shaped, saucerlike depressions or pits, characteristic of the genus. The female worm had lateral alae and the uterus full with similar eggs. In all 25 cases of human lagochilascariasis so far described, the location of the lesions was in the region of neck, ear, mastoid process, orbit, paranasal sinuses and retropharyngeal tissues. For the first time, the present case, a member of the genus Lagochilascaris is referred to in a different site of the host. Besides that, the finding of eggs, larvae and adult worms in the lung tissues strongly suggests the existence of a pulmonary cycle in human lagochilascariasis.