1. Dry eye in rheumatoid arthritis: relation to disease activity
- Author
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Waleed Mahmoud Abd El Hamid, Nashwa M. Abd-Allah, Sahar Torky A Abdelaziz, Mona Hamdy, Rabab A Moussa, Gihan Omar, and Amal A Hassan
- Subjects
Adult ,Male ,rheumatoid arthritis ,lcsh:Immunologic diseases. Allergy ,musculoskeletal diseases ,medicine.medical_specialty ,Time Factors ,genetic structures ,secondary sjögren’s syndrome (ss) ,Immunology ,Severity of Illness Index ,Disease activity ,dry eye ,Ophthalmology ,Internal medicine ,Biopsy ,Humans ,Immunology and Allergy ,Medicine ,Outpatient clinic ,Rheumatoid factor ,ocular tests ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,eye diseases ,Rheumatology ,stomatognathic diseases ,Erythrocyte sedimentation rate ,Rheumatoid arthritis ,Dry Eye Syndromes ,Female ,sense organs ,Rheumatic Fever ,disease activity score 28 (das-28) ,lcsh:RC581-607 ,business ,Anti-SSA/Ro autoantibodies - Abstract
The aim of this study was to find the correlation between severity of dry eye and rheumatoid arthritis (RA) disease activity. Forty- two RA patients with dry eye were recruited from Rheumatology Outpatient Clinic in Minia University Hospital. Assessment of RA disease activity was performed using disease activity score (DAS-28). Ocular tests include Schirmer test I, tear film break up time (TBUT) and ocular staining score (OSS) was performed by ophthalmologist to find evidence of ocular dryness. Erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti SSA/Ro and anti SSB/La was also tested. Patients with severe dry (OSS ≥ 3) underwent minor salivary gland biopsy (MSGB) as suspected to have secondary Sjögren's syndrome (SS). Of 42 RA patients, 30 had definite dry eye. DAS-28 did not show significant correlation with any of ocular tests for dryness while the duration of RA was significantly positively correlated with Schirmer test and OSS. The biopsy results of RA patients with severe dry eye show no evidence of SS. The severity of dry eye is not correlated with activity of RA but with its duration.
- Published
- 2020