1. Lower donated kidney volume is associated with increased risk of lower graft function and acute rejection at 1 year after living donor kidney—a retrospective study
- Author
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Filipa Silva, Jorge Malheiro, Diogo Nunes-Carneiro, Sofia Pedroso, Leonídeo Dias, Mariana Mandanelo, Nicole Pestana, Manuela Guedes de Almeida, Catarina Isabel Ribeiro, António Castro Henriques, La Salete Martins, Joana Tavares, and Miguel Silva-Ramos
- Subjects
Graft Rejection ,medicine.medical_specialty ,Urology ,Renal function ,Kidney Volume ,Nephron ,030230 surgery ,Kidney ,03 medical and health sciences ,0302 clinical medicine ,Living Donors ,Humans ,Medicine ,Kidney transplantation ,Retrospective Studies ,Body surface area ,Transplantation ,business.industry ,Surrogate endpoint ,Incidence (epidemiology) ,Graft Survival ,medicine.disease ,Kidney Transplantation ,medicine.anatomical_structure ,030211 gastroenterology & hepatology ,business ,Glomerular Filtration Rate - Abstract
Kidney volume has been proven to be a surrogate marker of nephron mass and renal function. We studied 190 donor and recipient pairs undergoing living donor kidney transplantation at our institution during 9 years. Different metrics of donor kidney volume (DKV) were explored: alone or indexed to recipient's anthropometry, as body surface area (BSA). DKV/BSA (min. 49.7; P33rd 77.7; P67th 95.3; max. 176 cm3 /m2 ) was chosen given its higher correlation with eGFR at 1 year, and recipients were divided according to its tertiles (T). The eGFR at 1 year was lower in T1, when compared with T2 (P = 0.015) and T3 (P
- Published
- 2020