1. Association between chronic kidney disease and new-onset dyslipidemia: The Japan Specific Health Checkups (J-SHC) study
- Author
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Takaaki Kosugi, Kazuhiko Tsuruya, Ichiei Narita, Fumihiro Fukata, Hikari Tasaki, Tsuyoshi Watanabe, Masaru Matsui, Koichi Asahi, Kunitoshi Iseki, Toshiki Moriyama, Tsuneo Konta, Masahiro Eriguchi, Ken-ichi Samejima, Yugo Shibagaki, Masatoshi Nishimoto, Shouichi Fujimoto, Masahide Kondo, Masato Kasahara, Kunihiro Yamagata, and Hisako Yoshida
- Subjects
medicine.medical_specialty ,Population ,Japan ,Risk Factors ,Internal medicine ,medicine ,Humans ,Longitudinal Studies ,Renal Insufficiency, Chronic ,Risk factor ,education ,Triglycerides ,Dyslipidemias ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Cholesterol, HDL ,Hazard ratio ,Hypertriglyceridemia ,nutritional and metabolic diseases ,medicine.disease ,Residual risk ,lipids (amino acids, peptides, and proteins) ,Cardiology and Cardiovascular Medicine ,Lipid profile ,business ,Dyslipidemia ,Kidney disease - Abstract
Dyslipidemias are common among patients with chronic kidney disease (CKD) and are a major risk factor for cardiovascular disease. This study aimed to investigate the association between early-stage CKD and new-onset dyslipidemia for each lipid profile.This nationwide longitudinal study included data from the Japan Specific Health Checkups (J-SHC) Study. New-onset dyslipidemia was indicated by hypertriglyceridemia (High-TG; ≥150 mg/dL), hyper-LDL cholesterolemia (High-LDL-C; ≥140 mg/dL), or hypo-HDL chelesterolemia (Low-HDL-C;40 mg/dL) levels according to the guideline of Japan Atherosclerosis Society, or High-TG/HDL-C ratio (≥3.5) which was a good predictor of atherosclerosis. The incidence of new-onset dyslipidemia was compared between participants with and without CKD. Survival curves were used to analyze the incidence of each dyslipidemia.Of 289,462 participants with a median follow-up period of 3 years, the incidence of High-TG, High-LDL-C, Low-HDL-C, and High-TG/HDL-C ratios were 64.4/1000 person-years, 83.1/1000 person-years, 14.5/1000 person-years, and 39.6/1000 person-years, respectively. The adjusted hazard ratios (95% confidence intervals) for High-TG, High-LDL-C, Low-HDL-C, and High-TG/HDL-C ratio were 1.09 (1.05-1.13), 0.99 (0.95-1.04), 1.12 (1.05-1.18), and 1.14 (1.09-1.18), respectively, in CKD participants as compared to non-CKD participants. Decreased eGFR and presence of proteinuria were independently associated with higher risks for new-onset of High-TG, Low-HDL-C, and High-TG/HDL-C ratios.CKD was associated with a higher risk of new-onset High-TG, Low-HDL-C, and High-TG/HDL-C ratios, but not High-LDL-C, in the general population. These CKD-specific lipid abnormalities may explain the residual risk for CKD-related cardiovascular disease.
- Published
- 2021