1. Primary cytomegalovirus infection during pregnancy and congenital infection: a population-based, mother–child, prospective cohort study
- Author
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Tomoaki Ikeda, Hidemi Toyoda, Keishiro Amano, Kuniaki Toriyabe, Masako Kitano, Shigeru Suga, Toshio Minematsu, Sawako Masuda, Kyoko Shimada, Fumihiro Morikawa, Satoko Usui, Asa Kitamura, and Makoto Ikejiri
- Subjects
medicine.medical_specialty ,Adolescent ,Congenital cytomegalovirus infection ,Cytomegalovirus ,Pathogenesis ,Antibodies, Viral ,Article ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Humans ,Medicine ,Avidity ,Prospective Studies ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,Prospective cohort study ,Aged ,030219 obstetrics & reproductive medicine ,biology ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,medicine.disease ,Mother-Child Relations ,Confidence interval ,Risk factors ,Immunoglobulin M ,Relative risk ,Cytomegalovirus Infections ,Pediatrics, Perinatology and Child Health ,biology.protein ,Female ,Antibody ,business ,Live birth - Abstract
Objective This study assessed maternal cytomegalovirus antibodies, and the occurrence of primary and congenital cytomegalovirus infections, and risk factors of congenital infection after a maternal primary infection. Study design We included 19,435 pregnant women in Japan, who were tested for serum cytomegalovirus antibodies before 20 gestational weeks. Immunoglobulin (Ig) G avidity was evaluated in women with both IgG and IgM antibodies; tests were repeated at ≥28 gestational weeks among women without IgG and IgM antibodies. Result Primary and congenital infections were 162 and 23 cases, respectively. The risk ratios for congenital infection were 8.18 (95% confidence interval: 2.44–27.40) in teenage versus older women, and 2.25 (95% confidence interval: 1.28–3.94) in parity ≥ 2 versus parity ≤ 1. Of 22 live birth congenital infection cases, three had abnormal neurological findings. Conclusion We demonstrated teenage and parity ≥ 2 pregnant women as risk factors of post-primary congenital infection.
- Published
- 2021
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