13 results on '"Karina G. Zecchin"'
Search Results
2. Prognostic significance of cyclooxygenase 2 and phosphorylated Akt1 overexpression in primary nonmetastatic and metastatic cutaneous melanomas
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Jacks Jorge, Maria Letícia Cintra, Karina G. Zecchin, Oslei Paes de Almeida, Rafael Fantelli Stelini, Marcondes Sena-Filho, Camilla F. Borges, Edgard Graner, and Ciro Dantas Soares
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0301 basic medicine ,Adult ,Cancer Research ,Skin Neoplasms ,Proliferation index ,Angiogenesis ,AKT1 ,Dermatology ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Phosphorylation ,Melanoma ,Survival analysis ,Aged ,Aged, 80 and over ,Tissue microarray ,Cell growth ,business.industry ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,030104 developmental biology ,Oncology ,Cyclooxygenase 2 ,030220 oncology & carcinogenesis ,Cancer research ,Immunohistochemistry ,Female ,business ,Proto-Oncogene Proteins c-akt - Abstract
Cyclooxygenase 2 (COX-2) and phosphorylated Akt1 (p-Akt1) are associated with tumor spreading, cell proliferation, high metabolism, and angiogenesis in solid tumors. This study aimed to investigate COX-2 and p-Akt1 expression in primary and metastatic melanomas by correlating with the cellular proliferation index (as revealed by minichromosome maintenance 2 expression) and the outcome of patients with malignant melanomas. Seventy-seven biopsies of malignant melanomas, including 42 primary nonmetastatic melanomas (PNMMs), 12 primary metastatic melanomas (PMMs), and 23 metastatic melanomas (MMs), were retrospectively selected. Tissue microarrays were developed and submitted for immunohistochemical staining for COX-2, p-Akt1, and minichromosome maintenance 2. Increased COX-2 cytoplasmic staining patterns were observed in PMM and MM when compared with PNMM (P=0.0011). Higher nuclear and cytoplasmic expression of p-Akt1 was more closely associated with PMM than with MM and PNMM (P
- Published
- 2017
3. The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas
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Fernanda Dos Santos Moreira, Michelle Agostini, Ricardo D. Coletta, Tuula Salo, Débora Campanella Bastos, Edgard Graner, Helena Fonseca Raposo, Rose Mara Ortega, Nivea Dias Amoedo, Karina G. Zecchin, Luciana Yamamoto Almeida, Fabiana Seguin, and Helena C. F. Oliveira
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Cancer Research ,medicine.medical_specialty ,Cell ,Apoptosis ,Metastasis ,Lactones ,Mice ,Prostate cancer ,Cell Line, Tumor ,Internal medicine ,medicine ,Carcinoma ,Animals ,Humans ,Cytotoxic T cell ,Neoplasm Metastasis ,Cell Proliferation ,Orlistat ,biology ,medicine.disease ,Xenograft Model Antitumor Assays ,Tongue Neoplasms ,Fatty Acid Synthase, Type I ,Fatty acid synthase ,medicine.anatomical_structure ,Endocrinology ,Oncology ,Cervical lymph nodes ,Tumor progression ,Carcinoma, Squamous Cell ,biology.protein ,Cancer research - Abstract
Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues such as liver, lactating breast, fetal lung, and adipose tissue. Conversely, several human cancers, including head and neck squamous cell carcinomas (HNSCC), overexpress FASN, which has been associated with poor prognosis and recently suggested as a metabolic oncoprotein. Orlistat is an irreversible inhibitor of FASN activity with cytotoxic properties on several cancer cell lines that inhibits tumor progression and metastasis in prostate cancer xenografts and experimental melanomas, respectively. To explore whether the inhibition of FASN could impact oral tongue squamous cell carcinoma (OTSCC) metastatic spread, an orthotopic model was developed by the implantation of SCC-9 ZsGreen LN-1 cells into the tongue of BALB/c nude mice. These cells were isolated through in vivo selection, show a more invasive behavior in vitro than the parental cells, and generate orthotopic tumors that spontaneously metastasize to cervical lymph nodes in 10 to 15 days only. SCC-9 ZsGreen LN-1 cells also exhibit enhanced production of MMP-2, ERBB2, and CDH2. The treatment with orlistat reduced proliferation and migration, promoted apoptosis, and stimulated the secretion of VEGFA165b by SCC-9 ZsGreen LN-1 cells. In vivo, the drug was able to decrease both the volume and proliferation indexes of the tongue orthotopic tumors and, importantly, reduced the number of metastatic cervical lymph nodes by 43%. These results suggest that FASN is a potential molecular target for the chemotherapy of patients with OTSCC. Mol Cancer Ther; 13(3); 585–95. ©2013 AACR.
- Published
- 2014
4. The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
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Ricardo D. Coletta, Fabiana Seguin, Marco Aurélio de Carvalho, Miryam Paola Alvarez-Flores, Débora Campanella Bastos, Ana Marisa Chudzinski-Tavassi, Karina G. Zecchin, Edgard Graner, and Michelle Agostini
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Vascular Endothelial Growth Factor A ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Cell Survival ,Angiogenesis ,Melanoma, Experimental ,Antineoplastic Agents ,Apoptosis ,Enzyme-Linked Immunosorbent Assay ,Lactones ,Mice ,angiogenesis ,Internal medicine ,melanoma ,medicine ,Animals ,Humans ,metastasis ,Enzyme Inhibitors ,RNA, Small Interfering ,neoplasms ,orlistat ,Cell Proliferation ,Mouth neoplasm ,fatty acid synthase ,Neovascularization, Pathologic ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,Cell growth ,Melanoma ,vascular endothelial growth factor A (VEGFA) ,medicine.disease ,respiratory tract diseases ,Gene Expression Regulation, Neoplastic ,Mice, Inbred C57BL ,Fatty acid synthase ,Orlistat ,Vascular endothelial growth factor A ,Endocrinology ,Oncology ,Carcinoma, Squamous Cell ,biology.protein ,Cancer research ,Mouth Neoplasms ,Fatty Acid Synthases ,Translational Therapeutics ,medicine.drug - Abstract
Background: Fatty acid synthase (FASN) is overexpressed and associated with poor prognosis in several human cancers. Here, we investigate the effect of FASN inhibitors on the metastatic spread and angiogenesis in experimental melanomas and cultured melanoma cells. Methods: The lung colonisation assay and cutaneous melanomas were performed by the inoculation of mouse melanoma B16-F10 cells in C57BL6 mice. Blood vessel endothelial cells (RAEC and HUVEC) were applied to determine cell proliferation, apoptosis, and the formation of capillary-like structures. Vascular endothelial growth factor A (VEGFA) expression was evaluated by quantitative RT–PCR and ELISA in B16-F10, human melanoma (SK-MEL-25), and human oral squamous carcinoma (SCC-9) cells. Conditioned media from these cancer cell lines were used to study the effects of FASN inhibitors on endothelial cells. Results: B16-F10 melanoma-induced metastases and angiogenesis were significantly reduced in orlistat-treated mice. Fatty acid synthase inhibitors reduced the viability, proliferation, and the formation of capillary-like structures by RAEC cells, as well as the tumour cell-mediated formation of HUVEC capillary-like structures. Cerulenin and orlistat stimulated the production of total VEGFA in B16-F10, SK-MEL-25, and SCC-9 cells. Both drugs also enhanced VEGFA121, 165, 189, and 165b in SK-MEL-25 and SCC-9 cells. Conclusion: FASN inhibitors reduce metastasis and tumour-induced angiogenesis in experimental melanomas, and differentially modulate VEGFA expression in B16-F10 cells.
- Published
- 2012
5. Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis
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Ricardo D. Coletta, Helena C. F. Oliveira, Luciane C. Alberici, Helena Fonseca Raposo, Karina G. Zecchin, Daniela R. Melo, Franco Aparecido Rossato, Roger F. Castilho, Edgard Graner, and Anibal E. Vercesi
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Programmed cell death ,Cell Survival ,Cell ,Apoptosis ,Enzyme-Linked Immunosorbent Assay ,Pathology and Forensic Medicine ,Lactones ,Mice ,chemistry.chemical_compound ,Cell Line, Tumor ,medicine ,Animals ,Melanoma ,Molecular Biology ,Cell Proliferation ,DNA Primers ,Orlistat ,Analysis of Variance ,biology ,Cell Cycle ,Cytochromes c ,Cell Biology ,Flow Cytometry ,medicine.disease ,Lipids ,Cerulenin ,Fatty acid synthase ,medicine.anatomical_structure ,Mitochondrial permeability transition pore ,chemistry ,Caspases ,Cutaneous melanoma ,biology.protein ,Cancer research ,Fatty Acid Synthesis Inhibitors ,Calcium ,RNA Interference ,Fatty Acid Synthases ,Reactive Oxygen Species - Abstract
Fatty acid synthase (FASN) is the metabolic enzyme responsible for the endogenous synthesis of the saturated long-chain fatty acid, palmitate. In contrast to most normal cells, FASN is overexpressed in a variety of human cancers, including cutaneous melanoma, in which its levels of expression are associated with tumor invasion and poor prognosis. We have previously shown that FASN inhibition with orlistat significantly reduces the number of spontaneous mediastinal lymph node metastases following the implantation of B16-F10 mouse melanoma cells in the peritoneal cavity of C57BL/6 mice. In this study, we investigate the biological mechanisms responsible for the FASN inhibition-induced apoptosis in B16-F10 cells. Both FASN inhibitors, cerulenin and orlistat, significantly reduced melanoma cell proliferation and activated the intrinsic pathway of apoptosis, as demonstrated by the cytochrome c release and caspase-9 and -3 activation. Further, apoptosis was preceded by an increase in both reactive oxygen species production and cytosolic calcium concentrations and independent of p53 activation and mitochondrial permeability transition. Taken together, these findings demonstrate the mitochondrial involvement in FASN inhibition-induced apoptosis in melanoma cells.
- Published
- 2011
6. Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
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Helena C. F. Oliveira, Ricardo D. Coletta, Karina G. Zecchin, Fabiana Seguin, Helena Fonseca Raposo, Edgard Graner, Débora Campanella Bastos, Marco Aurélio de Carvalho, Michelle Agostini, Ana Lúcia Carrinho Ayrosa Rangel, Silvio Sanches Veiga, and Massimo Loda
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Cancer Research ,Apoptosis ,Biology ,Metastasis ,Lactones ,Mice ,Cell Line, Tumor ,medicine ,Animals ,Melanoma ,neoplasms ,Peritoneal Neoplasms ,Cell Proliferation ,Orlistat ,Cell growth ,Cancer ,medicine.disease ,Enzyme Activation ,Mice, Inbred C57BL ,Disease Models, Animal ,Fatty acid synthase ,Oncology ,Lymphatic Metastasis ,Mediastinal lymph node ,Immunology ,Cutaneous melanoma ,Saturated fatty acid ,biology.protein ,Cancer research ,Fatty Acid Synthases ,Neoplasm Transplantation - Abstract
Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for growth and survival. In fact, FASN is overexpressed in a variety of human cancers including cutaneous melanoma, in which its levels of expression are associated with a poor prognosis and depth of invasion. Here, we show that the specific inhibition of FASN activity by the antiobesity drug Orlistat or siRNA is able to significantly reduce proliferation and promote apoptosis in the mouse metastatic melanoma cell line B16-F10. These results prompted us to verify the effect of FASN inhibition on the metastatic process in a model of spontaneous melanoma metastasis, in which B16-F10 cells injected in the peritoneal cavity of C57BL/6 mice metastasize to the mediastinal lymph nodes. We observed that mice treated with Orlistat 48 hr after the inoculation of B16-F10 cells exhibited a 52% reduction in the number of mediastinal lymph node metastases, in comparison with the control animals. These results suggest that FASN activity is essential for B16-F10 melanoma cell proliferation and survival while its inactivation by Orlistat significantly reduces their metastatic spread. The chemical inhibition of FASN activity could have a potential benefit in association with the current chemotherapy for melanoma.
- Published
- 2008
7. Smad7 blocks transforming growth factor-β1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor
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Edgard Graner, Lays M. Sobral, Ricardo D. Coletta, Pablo Agustin Vargas, Patrick Franz Montan, Hercílio Martelli-Júnior, and Karina G. Zecchin
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Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,Gingiva ,Connective tissue ,macromolecular substances ,SMAD ,Smad2 Protein ,Smad7 Protein ,Transforming Growth Factor beta1 ,Fibrosis ,medicine ,Humans ,Myofibroblasts ,integumentary system ,Chemistry ,Growth factor ,Connective Tissue Growth Factor ,Fibroblasts ,medicine.disease ,Hereditary gingival fibromatosis ,Cell biology ,CTGF ,medicine.anatomical_structure ,Gene Expression Regulation ,Cell Transdifferentiation ,Periodontics ,Myofibroblast ,Transforming growth factor ,Signal Transduction - Abstract
Transforming growth factor-β1 (TGF-β1), its downstream signaling mediators (Smad proteins), and specific targets, including connective tissue growth factor (CTGF), play important roles in tissue remodeling and fibrosis via myofibroblast activation. We investigated the effect of overexpression of Smad7, a TGF-β1 signaling inhibitor, on transition of gingival fibroblast to myofibroblast. Moreover, we analyzed the participation of CTGF on TGF-β1-mediated myofibroblast transformation.To study the inhibitory effect of Smad7 on TGF-β1/CTGF-mediating gingival fibroblast transition into myofibroblasts, we stably overexpressed Smad7 in normal gingival fibroblasts and in myofibroblasts from hereditary gingival fibromatosis (HGF). Myofibroblasts were characterized by the expression of the specific marker isoform α of the smooth muscle actin (α-SMA) by Western blot, flow cytometry, and immunofluorescence. Enzyme-linked immunosorbent assay for type I collagen was performed to measure myofibroblast activity. CTGF's role on myofibroblast transformation was examined by enzyme-linked immunosorbent assay and small interference RNA.TGF-β1 induced the expression of α-SMA and CTGF, and small interference RNA-mediating CTGF silencing prevented fibroblast-myofibroblast switch induced by TGF-β1. In Smad7-overexpressing fibroblasts, ablation of TGF-β1-induced Smad2 phosphorylation marked decreased α-SMA, CTGF, and type I collagen expression. Similarly, HGF transfectants overexpressing Smad7 demonstrated low levels of α-SMA and phospho-Smad2 and significant reduction on CTGF and type I collagen production.CTGF is critical for TGF-β1-induced gingival fibroblast-myofibroblast transition, and Smad7 overexpression is effective in the blockage of myofibroblast transformation and activation, suggesting that treatments targeting myofibroblasts by Smad7 overexpression may be clinically effective in gingival fibrotic diseases, such as HGF.
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- 2010
8. Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis
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Carolina Cavalcante Bitu, Márcio Ajudarte Lopes, Maria Fernanda de Souza Setúbal Destro, Edgard Graner, Karina G. Zecchin, Ricardo D. Coletta, and Luiz Paulo Kowalski
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Cancer Research ,Cell growth ,Cell ,Cancer ,Biology ,medicine.disease ,medicine.disease_cause ,medicine.anatomical_structure ,Oncology ,Downregulation and upregulation ,medicine ,Cancer research ,Carcinoma ,Hox gene ,Carcinogenesis ,Transcription factor - Abstract
A growing body of evidence has confirmed the involvement of dysregulated expression of HOX genes in cancer. HOX genes are a family of 39 transcription factors, divided in 4 clusters (HOXA to HOXD), that during normal development regulate cell proliferation and specific cell fate. In the present study it was investigated whether genes of the HOXB cluster play a role in oral cancer. We showed that most of the genes in the HOXB network are inactive in oral tissues, with exception of HOXB2, HOXB7 and HOXB 13. Expression of HOXB7 was significantly higher in oral squamous cell carcinomas (OSCC) compared to normal oral mucosas. We further demonstrated that HOXB7 overexpression in HaCAT human epithelial cell line promoted proliferation, whereas downregulation of HOXB7 endogenous levels in human oral carcinoma cells (SCC9 cells) decreased proliferation. In OSCCs, expression of HOXB7 and Ki67, a marker of proliferation, correlate strongly with each other (rs=0.79, p
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- 2009
9. Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis
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Lays M. Sobral, Inês Nobuko Nishimoto, Michele Gassen Kellermann, Luiz Paulo Kowalski, S. D. Da Silva, Márcio Ajudarte Lopes, Edgard Graner, Karina G. Zecchin, and Ricardo D. Coletta
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Poor prognosis ,Pathology ,Histology ,Pathology and Forensic Medicine ,Stroma ,Tongue ,Internal medicine ,Carcinoma ,medicine ,Humans ,Basal cell ,Neoplasm Staging ,business.industry ,General Medicine ,Fibroblasts ,medicine.disease ,Prognosis ,Immunohistochemistry ,Actins ,Tongue Neoplasms ,Carcinoma, Squamous Cell ,Neoplasm staging ,Female ,Stromal Cells ,business ,Myofibroblast ,Precancerous Conditions - Published
- 2007
10. Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes
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Michelle Agostini, Ricardo D. Coletta, Luiz Paulo Kowalski, Sabrina Daniela da Silva, Isabela Werneck da Cunha, Karina G. Zecchin, Ana Lúcia Carrinho Ayrosa Rangel, Jacks Jorge, and Edgard Graner
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Keratinocytes ,Male ,Pathology ,medicine.medical_specialty ,Receptor, ErbB-2 ,Cell ,Epithelium ,Pathology and Forensic Medicine ,Cell Line, Tumor ,Keratin ,Carcinoma ,medicine ,Humans ,skin and connective tissue diseases ,neoplasms ,Molecular Biology ,Cells, Cultured ,Cell Proliferation ,chemistry.chemical_classification ,Mouth ,Tissue microarray ,biology ,Cell growth ,Cell Biology ,General Medicine ,medicine.disease ,Gene Expression Regulation, Neoplastic ,stomatognathic diseases ,medicine.anatomical_structure ,chemistry ,Gene Expression Regulation ,Cell culture ,Head and Neck Neoplasms ,Ki-67 ,biology.protein ,Carcinoma, Squamous Cell ,Female ,Mouth Neoplasms ,Fatty Acid Synthases - Abstract
The aim of this study was to investigate fatty acid synthase (FAS) and ErbB2 expression in nonmalignant oral epithelium and oral or head and neck squamous cell carcinomas (OSCC/HNSCC). Morphologically normal, hyperkeratotic, and dysplastic oral epithelium as well as well-differentiated and poorly differentiated OSCC were immunohistochemically evaluated for FAS, ErbB2, and Ki-67. These proteins were also analyzed in a tissue microarray with 55 HNSCC. SCC-9 cells were used to study FAS and ErbB2 during differentiation. FAS expression was higher in hyperkeratosis, dysplasias, and OSCC than in normal epithelium. Well-differentiated OSCC/HNSCC were more positive for FAS than the poorly differentiated tumors. ErbB2 was observed at the surface of nonmalignant and well-differentiated OSCC/HNSCC keratinocytes and in the cytoplasm of poorly differentiated cells. Ki-67 index was progressively higher from normal oral epithelium to OSCC, inversely correlated with cell surface ErbB2, and positively correlated with intracytoplasmic ErbB2. Finally, SCC-9 cell cultures were enriched in membrane ErbB2-positive cells after differentiation by anchorage deprivation. In conclusion, FAS is overexpressed in OSCC/HNSCC and hyperkeratotic oral epithelium and ErbB2 is found at the cell surface of differentiating keratinocytes and in the cytoplasm of poorly differentiated tumor cells. Ki-67 index is higher in epithelial dysplasias and OSCC than in morphologically normal oral epithelium.
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- 2007
11. Oral Malignant Melanoma: A Case Report and Literature Review
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Pablo Agustin Vargas, Camilla Borges Ferreira Gomes, Alan Roger dos Santos Silva, Oslei Paes de Almeida, Karina G. Zecchin, and Márcio Ajudarte Lopes
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medicine.medical_specialty ,business.industry ,Melanoma ,medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Surgery ,Oral Surgery ,medicine.disease ,business ,Dermatology ,Pathology and Forensic Medicine - Published
- 2015
12. Heterogeneous presence of myofibroblasts in hereditary gingival fibromatosis
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Lays M. Sobral, Ricardo D. Coletta, Michele Gassen Kellermann, Hercílio Martelli-Júnior, Karina G. Zecchin, Carolina Cavalcante Bitu, and Edgard Graner
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Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,Blotting, Western ,Gingiva ,Connective tissue ,Biology ,Immediate-Early Proteins ,Transforming Growth Factor beta1 ,Transforming Growth Factor beta ,medicine ,Humans ,Fibroblast ,Fibromatosis, Gingival ,Analysis of Variance ,Reverse Transcriptase Polymerase Chain Reaction ,Growth factor ,Transdifferentiation ,Connective Tissue Growth Factor ,Fibroblasts ,medicine.disease ,Hereditary gingival fibromatosis ,Actins ,CTGF ,medicine.anatomical_structure ,Periodontics ,Intercellular Signaling Peptides and Proteins ,Myofibroblast ,Type I collagen - Abstract
Background/Aim: Hereditary gingival fibromatosis (HGF) fibroblasts are characterized by an increased production of collagen and transforming growth factor-β1 (TGF-β1), resulting in a fibrotic enlargement of the gingiva of affected patients. A common feature of interstitial fibrosis is the occurrence of myofibroblasts, which are regarded as the predominant cells in matrix synthesis. The goal of this article is to describe the presence of myofibroblasts in HGF in order to elucidate the mechanisms underlying HGF gingival overgrowth. Materials and Methods: Fibroblast cell lines and gingival samples from patients of two distinct families affected by HGF and from normal gingiva (NG) were included in this study. To characterize the presence of myofibroblasts, the expression of specific myofibroblast marker smooth muscle isoform of α-actin (α-SMA) was examined by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), Western blot, immunofluorescence, and flow cytometric analysis. Immunohistochemistry against the α-SMA antigen was performed in the gingival tissue samples. Results: Our results demonstrated a significant increase in the expression of the myofibroblast marker α-SMA in cells from one HGF family (designed as HGF Family 2), which are also characterized by an elevated expression of type I collagen, TGF-β1 and connective tissue growth factor (CTGF). Additionally, α-SMA-positive cells were broadly detected in the gingival tissue samples from HGF Family 2 patients. In contrast, α-SMA expression by HGF Family 1 cells was quite similar to NG cells and no myofibroblasts were detected immunohistochemically, despite the higher levels of TGF-β1 and type I collagen in HGF Family 1 fibroblasts than in NG cells. The expression of CTGF, which has been considered a key molecule to promote the transdifferentiation of myofibroblasts via TGF-β1 activation, by HGF Family 1 cultures was significantly lower compared with HGF Family 2 and similar to NG control cells. Conclusions: Our results suggest that the presence of myofibroblasts in HGF could be dependent on CTFG expression levels, and different biological mechanisms may account for the gingival overgrowth observed in HGF patients. This could be an underlying reason for the high variable clinical expressivity of disease.
- Published
- 2006
13. 675 Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis
- Author
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Edgard Graner, L.P. Kowalski, Márcio Ajudarte Lopes, R. D. Coletta, Karina G. Zecchin, C. Cavalcante Bitu, and Maria Fernanda de Souza Setúbal Destro
- Subjects
Cancer Research ,Poor prognosis ,business.industry ,Homeobox A1 ,Cancer ,medicine.disease ,HNF1A ,homeobox A9 ,Oncology ,Cancer research ,Medicine ,Homeobox ,CDX2 ,business - Published
- 2010
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