1. Predictors of outcomes in patients with mitral regurgitation undergoing percutaneous valve repair
- Author
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Carmen Spaccarotella, Michele Albanese, Ciro Indolfi, Nadia Salerno, Salvatore De Rosa, Isabella Leo, Annalisa Mongiardo, Sabato Sorrentino, Iolanda Aquila, Alberto Polimeni, Michele Cacia, Jolanda Sabatino, Vincenzo Signorile, Polimeni, A., Albanese, M., Salerno, N., Aquila, I., Sabatino, J., Sorrentino, S., Leo, I., Cacia, M., Signorile, V., Mongiardo, A., Spaccarotella, C., De Rosa, S., and Indolfi, C.
- Subjects
Male ,medicine.medical_specialty ,Cardiac Catheterization ,Percutaneous ,lcsh:Medicine ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Retrospective Studie ,Internal medicine ,medicine ,Clinical endpoint ,Cardiac Surgical Procedure ,Humans ,030212 general & internal medicine ,Cardiac Surgical Procedures ,lcsh:Science ,Cardiac device therapy ,Aged ,Retrospective Studies ,Echocardiography ,Female ,Heart Failure ,Heart Valve Prosthesis Implantation ,Hospitalization ,Mitral Valve ,Mitral Valve Insufficiency ,Treatment Outcome ,Mitral regurgitation ,Multidisciplinary ,business.industry ,MitraClip ,Incidence (epidemiology) ,lcsh:R ,Retrospective cohort study ,medicine.disease ,Heart failure ,Cardiology ,lcsh:Q ,business ,Interventional cardiology ,Percutaneous Mitral Valve Repair ,Human - Abstract
Percutaneous mitral valve repair has been increasingly performed worldwide after approval. We sought to investigate predictors of clinical outcome in patients with mitral regurgitation undergoing percutaneous valve repair. The MITRA-UMG study, a single-centre registry, retrospectively collected consecutive patients with symptomatic moderate-to-severe or severe MR undergoing MitraClip therapy. The primary endpoint was the composite of cardiovascular death or rehospitalization for heart failure. Between March 2012 and July 2018, a total of 150 consecutive patients admitted to our institution were included. Procedural success was obtained in 95.3% of patients. The composite primary endpoint of cardiovascular death or rehospitalization for HF was met in 55 patients (37.9%) with cumulative incidences of 7.6%, 26.2%, at 30 days and 1-year, respectively. In the Cox multivariate model, NYHA functional class and left ventricular end-diastolic volume index (LVEDVi), independently increased the risk of the primary endpoint at long-term follow-up. At Kaplan–Meier analysis, a LVEDVi > 92 ml/m2 was associated with an increased incidence of the primary endpoint. In this study, patients presenting with dilated ventricles (LVEDVi > 92 ml/m2) and advanced heart failure symptoms (NYHA IV) at baseline carried the worst prognosis after percutaneous mitral valve repair.
- Published
- 2020