1. Darolutamide in hormone-sensitive and castration-resistant prostate cancer
- Author
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Giandomenico Roviello, Ugo De Giorgi, Valeria Emma Palmieri, Alberto D'Angelo, Chiara Casadei, and Roberta Giorgione
- Subjects
Male ,Oncology ,medicine.medical_specialty ,Darolutamide ,Disease ,Castration resistant ,030226 pharmacology & pharmacy ,Pharmacology, Toxicology and Pharmaceutics(all) ,03 medical and health sciences ,chemistry.chemical_compound ,Prostate cancer ,0302 clinical medicine ,androgen receptor antagonist ,SDG 3 - Good Health and Well-being ,Internal medicine ,Nitriles ,Phenylthiohydantoin ,Androgen Receptor Antagonists ,medicine ,Animals ,Humans ,Enzalutamide ,Pharmacology (medical) ,Clinical efficacy ,General Pharmacology, Toxicology and Pharmaceutics ,hormone-sensitive ,business.industry ,Apalutamide ,General Medicine ,prostate cancer ,medicine.disease ,Hormone-sensitive ,Prostatic Neoplasms, Castration-Resistant ,non-metastatic ,Thiohydantoins ,chemistry ,030220 oncology & carcinogenesis ,Benzamides ,Pyrazoles ,castration-resistant ,business - Abstract
Introduction: Important changes in the treatment of prostate cancer have taken place in recent years. Non-metastatic castration-resistant prostate cancer (nmCRPC) has been clinically delineated. In this setting, three drugs have been approved in high-risk disease: apalutamide, enzalutamide and darolutamide.Areas covered:This manuscript aims to profile darolutamide, its clinical development, pharmacologic properties, efficacy and safety. We presented the results of published clinical studies, but we also investigated ongoing ones.Expert opinion: An indirect comparison with the other two aforementioned drugs emerged. While the clinical efficacy is comparable, the toxicity profile is different for darolutamide, resulting in greater tolerance. We must wait for the results of the trials that study darolutamide in hormone-sensitive disease, both in the metastatic phase and in the localized phase. Clinical experience will also be important to determine ever more personalized treatments for patients.
- Published
- 2021