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2. The Impact of The Coronavirus Disease 2019 Outbreak on The Quality of Life of Patients with Epilepsy

Author

Hayrunisa Dilek Atakli, M. Uzulmez Yildiz, Zeynep Bastug Gul, F. Varlibas, Mehmet Gül, Aysun Soysal, S. Aksoy, B. Tuzun Mutluer, S. R. Teker, and R. G. Gozubatik Celik

Subjects
Pediatrics, medicine.medical_specialty, Multivariate analysis, Coronavirus disease 2019 (COVID-19), business.industry, Outbreak, medicine.disease, Mental health, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Pandemic, medicine, Marital status, 030212 general & internal medicine, business, Psychosocial, 030217 neurology & neurosurgery
Abstract

Objectives: We aimed to investigate the effects of the coronavirus disease 2019 (COVID-19) outbreak on the quality of life (QOL) of patients with epilepsy. Methods: A total of 104 epilepsy patients admitted to our hospital during October and November of 2019 were evaluated for their QOL using the QOL in Epilepsy-31 questionnaire. These assessments were repeated in July 2020 and August 2020 to evaluate the impact of the epidemic on the QOL of epilepsy patients in the same group. The data of the patients were analyzed in SPSS. Results: During the pandemic period, overall score values decreased significantly compared to the pre-pandemic period (p=0.049). Although most of the subscores worsened with the pandemic, the most significant deterioration was observed in emotional well-being (p=0.021). There were six patients (5.8%) whose seizure frequency increased during the pandemic period. In the multivariate analysis, the only parameter that predicted an increase in seizure frequency during COVID-19 was the overall score. Overall score had a positive correlation with educational level. Disease duration, age, marital status, and number of drugs used were found to be negatively correlated with the overall score of the patients. Conclusion: The COVID-19 epidemic causes a significant deterioration in QOL in patients with epilepsy. During epidemics such as COVID-19, clinicians should consider psychosocial factors. In patients with epilepsy, measures should be taken not only to control seizures but also to prevent deterioration in mental health and QOL.

Published
2021
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3. The Investigation of the Effect of Continuous Positive Airway Pressure Treatment on Metabolic Syndrome and Insuline Resistance in Obstructive Sleep Apnea Syndrome Patients

Author

Vasfiye İlbay, Mehmet İlbay, Hayrunisa Dilek Atakli, Yeşim Kaykı, Mesrure Köseoğlu Bitnel, Nermin Görkem Şirin İnan, Oya Öztürk, and Aysun Soysal

Subjects
medicine.medical_specialty, lcsh:R5-920, business.industry, medicine.medical_treatment, lcsh:R, lcsh:Medicine, medicine.disease, metabolic syndrome, respiratory tract diseases, Obstructive sleep apnea, Obstructive sleep apnea syndrome, Internal medicine, insulin resistance, medicine, Cardiology, Continuous positive airway pressure, Metabolic syndrome, business, lcsh:Medicine (General), continuous positive airway pressure
Abstract

Objective: To evaluate the effect of continuous positive airway pressure (CPAP) treatment on metabolic syndrome and insuline resistance in patients with obstructive sleep apnea syndrome (OSAS). Materials and Methods: This study evaluated retrospectively with 30 patients who received OSAS diagnosis following polysomnography between the years January 2016 - January 2017, whose Respiratory Disturbance Index were above 15, and who were between the ages of 18-78, having no diabetes, chronic liver and kidney disease, malignancy and mental retardation. The anthropometric measures and blood values of these patients before the CPAP treatment and 3 months afterwards were evaluated in their controls. The effect of CPAP treatment on metabolic syndrome and insulin resistance assessed by homeostatic model assessment index was investigated. Results: It has been observed that the body mass index (BMI) decreases significantly following the CPAP treatment. No significant changes were found in the anthropometric measurements including the neck circumference, waist circumference, hip circumference, and waist/hip ratios as well as insulin resistance and metabolic syndrome parameters (before of treatment BMI: 31.33±5.58, post treatment BMI: 30.83±7.13, p=0.03). The ESS evaluating the subjective daytime sleepiness following the CPAP treatment has decreased significantly. Conclusion: Although this study didn’t improve insulin resistance with assessed homeostatic model assessment, and metabolic syndrome, a significant improvement in BMI and ESS was demonstrated in post treatment. Long-term studies with more cases and with high compliance are needed to demonstrate the effects of CPAP treatment on metabolic syndrome in OSAS patients.

Published
2017

4. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Özge Şahmelikoğlu Onur, Merve Çukurova, Sevda Bağ, Suat Yalçın, Cansu Çakır Şen, Çağatay Karşıdağ, Serdar Süleyman Can, Emine Tuğçe Akçaer, Ayşegül Taşdelen Kul, Mustafa İspir, Osman Bakkal, Ayhan Algül, Servet Ebrinç, Cihad Yükselir, Serkan Zincir, Pelin Öztürk, Bülent Karaahmetoğlu, Özlem Baş, Sema Ulukaya, Çağlar Soykan, Ali Çayköylü, Neslihan Yazar, Zehra Başar Kocagöz, Adnan Özçetin, Safiye Bahar Ölmez, Ahmet Ataoğlu, Yasin Hasan Balcioglu, Tonguc Demir Berkol, Filiz Ekim Cevik, Fatih Oncu, Guliz Ozgen, Dudu Demiröz, Hatice Yardım Özayhan, Hilal Seven, Mustafa Çağrı Yıldız, Recep Başaran, İbrahim Eren, Elif Özlem Canazlar, Levent Sevinçok, Bilge Doğan, Çağdaş Öykü Memiş, Ali Baran Tanrikulu, İkbal İnanli̇, Mustafa Çağri̇ Yi̇ldi̇z, Tuba Şerife Elmas, Ibrahim Eren, Şükrü Alperen Korkmaz, Cansu Pınar Şen, Mehmet Fatih Ceylan, Selma Tural Hesapçıoğlu, Burcu Bakar, Can Tuncer, Rümeysa Yeni Elbay, Aynur Görmez, Yusuf Tokgöz, Abdullah Bolu, Cemil Çelik, Özcan Uzun, Simge Seren Kirlioglu, Pinar Cetinay Aydin, Mustafa Uğurlu, Görkem Karakaş Uğurlu, Zuhal Koç, Nazlı Kapubağlı, Ömer Faruk Tuncer, Gülsen Ünlü, Esra Kabadayı Şahin, Zuhal Koç Apaydın, Semra Ulusoy Kaymak, Oğuz Peker, Bedriye Özkan, Ali Güven Kılıçoğlu, Gül Karaçetin, Zeynep Yücehan, Tuğba Şerife Elmas, Nafiye Yağlı, Bilge Çetin İlhan, Derya Adali Aker, Yiğit Kıvılcım, Mustafa Solmaz, Yeşim Ruhat Kutlu, Bahar Yeşil, Behice Han Almış, Başak Küçük, Cem Cerit, Burcu Sarici, Ayşe Ceren Kaypak, Erensu Baysak, Serhat Ergün, Mesut Yildiz, Aslihan Okan Ibiloglu, Abdullah Atli, Mehmet Asoglu, Mustafa Ozkan, Nursu Çakın Memik, Hatice Ünver, Özlem Yıldız Gündoğdu, Necati Uzun, Ömer Faruk Akça, Gizem Aral, Demet Sağlam Aykut, Özgür Maden, İbrahim Gündoğmuş, Fulya Gok, Seda Kiraz, Arif Cipil, Meliha Zengin Eroglu, Elvan Çiftçi, Zeynep Aslan, Melike Kevser Gül, Neslihan Taştepe, Esra Demirci, Sevgi Özmen, Hicran Doğru, Elif Karayağmurlu, Ali Karayağmurlu, Muhsine Göksu, Leyla Ezgi Tügen, Ayşe Burcu Ayaz, Ayşe Arman, Deniz Altunova, Murat İlhan Atagün, Ekrem Güldaş, Güler Göl, Uğur Savcı, Ali Evren Tufan, Seda Yıldırım Özbek, Süleyman Özbek, Hilal Uygur, Başak Demirel, İ. Esra Çiçek, Hüseyin Kara, Mehmet Murat Balcı, Servet Karaca, Mehmet Murat Kuloğlu, Hasan Mervan Aytaç, Mehmet Can Ger, Aslıhan Okan İbiloğlu, Mehmet Asoğlu, Ayşe Çakır, Ahmet Tiryaki, Gülşah Güçlü Çelme, Mehmet Hamid Boztaş, Fatma Sırmatel, Mucahid Erdogan, Cengiz Dayan, Hayrunisa Dilek Atakli, Gülşen Kartalcı, Ebru Yücel, Şükrü Kartalcı, Meliha Zengin Eroğlu, Arif Çipil, Mecit Çalışkan, Emine Cengiz Çavusoglu, Yusuf Özay Özdemir, Ebru Fındıklı, Berkan Şahin, Koray Karabekiroğlu, Mustafa Kurt, Doğa Sevinçok, Merve Sertdemir, Rukiye Ay, Nevzat Yılmaz, Sevcan Karakoç Demirkaya, Hatice Aksu, Hacer Gizem Gerçek, Gülser Karakoç, Ayşe Ender Altıntoprak, Hakan Coşkunol, Ipek Percinel Yazici, Kemal Utku Yazici, Kevser Altıntaş, Fulya Gök, Ferhat Yaylacı, Handan Özek Erkuran, Murat Eyüboğlu, Diğdem Göverti, Rabia Nazik Yüksel, Alper Bülbül, Makbule Çiğdem Aydemir, Erol Göka, Ilgaz Kınalı, Münevver Yıldırım Hacıoğlu, Burcu Sarıcı, Kemal Sayar, Hatice Doğan, Ömer Akay, Heecheol Kim, Hyunjoo Lee, Abdulkadir Karagöz, Hakan Kullakçı, Yasin Duman, Yusuf Çokünlü, Memduha Aydın, Ali Baran Tanrıkulu, İbrahım Eren, Hande Ayraler Taner, Burcu Akın Sarı, Çiğdem Yektaş, Nuran Demir Samurcu, Saliha Çalışır, Özalp Ekinci, Muhammet Emin Tan, Merve Kalınlı, Murat Kıyançiçek, Meltem Küçükdağ, Hasret Karabulut Gül, Emel Uysal, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Burak Karakök, Halime Tuna Çak, Pınar Kızılay Çankaya, İlkay Keleş Altun, Eren Abatan, Ali Metehan Çalışkan, Hatice Kübra Çakı, Burak Doğangün, Muhammed Tayyib Kadak, Mehmet Kefeli, Asiye Arıcı, Hatice Altun, Can Acıpayam, Pelin Çon Bayhan, Elif Nurgül Sungur, Ayşe Nur İnci Kenar, Sevde Afife Ersoy, Mehmet Gürkan Gürok, Sevler Yildiz, Tuba Korucu, Denizhan Danaci Keles, Murad Atmaca, Esra Hoşoğlu, Kübra Kılınç, Barış Şen, Erdem Örnek, Cengiz Çelebi, Ayşe Sakallı Kani, Ömer Yanartaş, Zeynep Şenkal, Yıldız Akvardar, Kaan Kora, Ümran Egilmez, Ali Kandeğer, Özkan Güler, Selcen Dogru Kösker, Elif Ates Budak, Zeliha Deveci Karasin, Mehmet Diyaddin Güleken, Mustafa Celik, Hande Yıldırım, Burçin Güler, Baybars Veznedaroğlu, Funda Lale, Halime Tuna Çak Esen, Göknur Haliloğlu, Nuran Ekinci, Gamze Özçürümez Bilgili, Volkan Seneger, Ümit Işık, Gonca Aşut, Elif Tatlıdil Yaylacı, Ömer Asan, Serkan Güneş, Ebru Çiftçi, Sehure Azra Yaşar, İkbal İnanlı, Sencan Sertçelik, Selma Hilal Avci, Alişan Burak Yaşar, Hasan Turan Karatepe, Melike Dönmez, Volkan Topçuoğlu, Ayhan Bilgiç, Volkan Doğru, Abdullah Bozkurt, Tuğba Kalyoncu, Deniz Argüz Çıldır, Can Beşer, Neşe Perdahlı Fiş, Şermin Bilgen Ulgar, Hamza Ayaydın, Hatice Takatak, Hamza Ayaydin, Cansu Çobanoğlu, Mahmut Müjdeci, Yusuf Yasin Gümüş, Betül Akbaş, Feyza Hatice Sevgen, Fatih Öncü, Nilfer Şahin, Damla Balkan, Fatma Coşkun, Savaş Yılmaz, Çağla Çelikkol, Ganime Dilek Emlik, Hüseyin Çaksen, Derya Arslan, Özden Arısoy, Ahmet Şair, Yaşan Bilge Şair, Dilek Sarı, Mustafa Ispir, Ayhan Algul, Vuslat Kara Ölmeztoprak, Esra Porgalı Zayman, Süheyla Ünal, Ali Hakan Öztürk, Başak Karabucak, Ebru Sadriye Çengel Kültür, Tuna Halime Çak Esen, İpek Fatma Özaktaç, Murat Altın, Ayşe Sena Sarıdoğan, Eser Buluş, Sevilay Güneş, Zehra Koyuncu, Rahime Hülya Bingöl, Mine Uzgel, Selahattin Ayas, Yüksel Kıvrak, Yiğit Şahbal, Kübra Kocagöz, Gamze Kutlu, Ali Baz, Mehmet Akif Cansız, Tugba Kalyoncu, Ebru Sağlam, Özlem Önen, Ayşe Kutlu, Ecenur Aydın Aşık, Şermin Yalın Sapmaz, Serpil Erermiş, Şahika Gülen Şişmanlar, İsmail Karka, Fethiye Kilicaslan, Ceren Enüstün Hürmeydan, Ozge Sahmelikoğlu Onur, Didem Nagehan Sarı, Bahar Kılıç, Elif Merve Kurt, İsmail Ak, Ali Emre Şevik, Ayşe Dilara Yalçın, Ümit Tural, Hilmi Yaşar, Münir Karaaslan, Fatih Kizilağaç, Taner Öznur, Ali̇ Baran Tanri̇kulu, Mustafa Çağri Yildiz, İkbal İnanli, Seher Serez Öztürk, Seda Özbek, İsmet Esra Çiçek, Rıfat Karlıdağ, Mustafa Akan, Lara Utku İnce, İsmail Reyhani, Dilek Çağlar Tetik, Ayşe Büyükaslan, Musa Yılanlı, Ender Cesur, Fatma Belger, Bürge Kabukçu Başay, Cansu Pinar Şen, Selma Tural Hesapcioglu, Gülşen Teksin, Nese Yorguner Kupeli, Serhat Ergun, Abdullah Atlı, Öznur Akıl, and Aslıhan Okan İbilioğlu

Subjects
medicine.medical_specialty, Treatment response, Alternative medicine, Neurosciences. Biological psychiatry. Neuropsychiatry, medicine.disease, behavioral disciplines and activities, Comorbidity, Child and adolescent, Psychiatry and Mental health, Schizophrenia, International congress, mental disorders, medicine, Pharmacology (medical), Psychopharmacology, Psychology, Psychiatry, RC321-571, Clinical psychology
Abstract

0009Obsessive-Compulsive Disorder Comorbidity in Children with Schizophrenia: Treatment Response and Clinical CourseABSTRACTObjective: Obsessive-compulsive disorder (OCD) is notably co-mor...

Published
2017
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5. The relationship between DIRAS1 gene and idiopathic generalized epilepsy in the Turkish population

Author

Zeynep Bastug Gul, Hayrunisa Dilek Atakli, Günay Gül, Cigdem Ozkara, Rabia Gökçen Gözübatik Çelik, Hüseyin Sari, Yasemin Akıncı, Ayten Ceyhan Dirican, Fulya Eren, Özlem Kaplan, Murat Pekmez, and Emel Ur Özçelik

Subjects
Genetics, education.field_of_study, Turkish population, Population, Biology, medicine.disease, law.invention, Idiopathic generalized epilepsy, Epilepsy, law, Genotype, medicine, Myoclonic epilepsy, education, Allele frequency, Polymerase chain reaction
Abstract

Idiopathic generalized epilepsy (IGE) is a type of epilepsy with a monogenic or polygenic inheritance pattern representing 47% of all epilepsies. Idiopathic epilepsies have a complex genetic structure and the genetic factors involved in the development of epilepsy are still unclear. Dog models are often used in researching the complex genetic basis of epilepsy. A study of Rhodesian Ridgeback (RR) dogs with generalized myoclonic epilepsy found a 4-bp-deletion in the second exon of the DIRAS1 gene. In the literature, there is no study on the presence of a relationship between DIRAS1 gene and epilepsy in human population. We aimed to analyze whether there is a relationship between human epilepsy and DIRAS1 gene. For genomic analysis, peripheral blood samples were taken from 109 patients diagnosed with IGE and 51 healthy volunteers in the Turkish population. Genomic DNA isolation was performed from blood samples and the DIRAS1 gene region of the genomic DNA was amplified by Polymerase Chain Reaction (PCR). PCR products were purified and sequenced. DNA sequencing results were analyzed by chi-squared test. In the patient and control groups, G/C change was found in nucleotide 549 of DIRAS1 gene. No significant correlation was found between the distribution of DIRAS1-549-G/C genotypes and allele frequencies (p = 0.8 and p = 0.7, respectively). In this study, DIRAS1-549-G/C polymorphism has been shown not to play an important role in the development of epilepsy in the Turkish population. As a result, new data on IGEs whose molecular mechanism is still not fully elucidated has been revealed.

Published
2021
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6. Our experience of spinal dural arteriovenous fistula: 4 case reports

Author

Hatem Hakan Selcuk, Zeynep Ezgi Balçık, Merve Yatmazoğlu, Batuhan Kara, Mucahid Erdogan, Songul Senadim, and Hayrunisa Dilek Atakli

Subjects
medicine.medical_specialty, business.industry, lcsh:R, medicine, endovascular, lcsh:Medicine, Arteriovenous fistula, spinal dural arteriovenous fistula, medicine.disease, business, Spinal arteriovenous malformation, Surgery
Abstract

Spinal dural arteriovenous fistula, which is caused by the low flow shunts between dural arteries and the perimedullary venous system shows progressive myelopathy signs. It is usually found in the thoracic region. It is vital to accurately make differential diagnosis since the disease may cause irreversible injury. In this case report we aimed to discuss four cases of spinal arteriovenous fistula that showed different outcomes.

Published
2017
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7. The Effect of Cognitive Functions on EEG in Patients with Juvenile Myoclonic Epilepsy

Author

Huseyin Turan Atay, Figen Demir, Hayrunisa Dilek Atakli, Baki Arpaci, and Pelin Dogan Ak

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Neuropsychology, Cognition, Electroencephalography, Audiology, medicine.disease, neuropsychological EEG activation, lcsh:RC346-429, lcsh:RC321-571, Juvenile myoclonic epilepsy, Frontal lobe, Neuroimaging, Cortical abnormalities, medicine, In patient, business, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system
Abstract

Summary Objectives: In this study, we aimed to show any effect of different types of cognitive activities on the electroencephalography (EEG) of patients with juvenile myoclonic epilepsy (JME). Methods: 30 patients with JME who stated that their seizures are not effected by any mental activity were submitted to a 30-minute standard awake video EEG. A neuropsychological activation battery (NPA) was performed during the ongoing video EEG. Results: The provocative effect of at least one test of NPA was observed in seven of 30 patients (23.3%) and the inhibitory effect of NPA was observed in nine of 30 patients (30.0%). Conclusion: We demonstrated that increased attention, concentration, and the tests associated generally with the frontal lobe functions were crucial for provocating the EEG discharges. This may support the studies with neuropsychological tests and structural neuroimaging techniques showing focal cortical abnormalities mainly associated with frontal lobe in JME.

Published
2013
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