1. High-density epicardial mapping in Brugada syndrome: Depolarization and repolarization abnormalities
- Author
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Shuichiro Kazawa, Gian-Battista Chierchia, P. Vergara, Gaetano Paparella, Cinzia Monaco, Dimitrios Sofianos, Vincenzo Miraglia, Federico Cecchini, Ingrid Overeinder, Paul-Adrian Călburean, Juan Sieira, Antonio Bisignani, Joerelle Mojica, Antanas Strazdas, Thiago Guimarães Osório, Carlo de Asmundis, Anais Gauthey, Gudrun Pappaert, Sergio Rizzi, Gezim Bala, Luigi Pannone, Alexandre Almorad, Erwin Ströker, Pedro Brugada, Felicia Lipartiti, Maysam Al Housari, Mark La Meir, Antonio Sorgente, Robbert Ramak, Clinical sciences, Faculty of Medicine and Pharmacy, Heartrhythmmanagement, Cardiology, Cardio-vascular diseases, Medical Imaging, Vascular surgery, Surgical clinical sciences, and Cardiac Surgery
- Subjects
Epicardial Mapping ,medicine.medical_specialty ,sudden cardiac death ,Sudden cardiac death ,Electrocardiography ,Physiology (medical) ,Internal medicine ,Medicine ,Repolarization ,Ventricular outflow tract ,Humans ,Ventricular tachycardia ablation ,cardiovascular diseases ,Brugada syndrome ,Brugada Syndrome ,Retrospective Studies ,Ajmaline ,Epicardial mapping ,business.industry ,Depolarization ,medicine.disease ,Electrocardiographic imaging ,electrocardiographic imaging ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,High-density mapping ,medicine.drug - Abstract
BACKGROUND: The pathogenesis of Brugada syndrome (BrS) and consequently of abnormal electrograms (aEGMs) found in the epicardium of the right ventricular outflow tract (RVOT-EPI) is controversial. OBJECTIVE: The purpose of this study was to analyze aEGM from high-density RVOT-EPI electroanatomic mapping (EAM). METHODS: All patients undergoing RVOT-EPI EAM with the HD-Grid catheter for BrS were retrospectively included. Maps were acquired before and after ajmaline, and all patients had concomitant noninvasive electrocardiographic imaging with annotation of RVOT-EPI latest activation time (RVOTat). High-frequency potentials (HFPs) were defined as ventricular potentials occurring during or after the far-field ventricular EGM showing a local activation time (HFPat). Low-frequency potentials (LFPs) were defined as aEGMs occurring after near-field ventricular activation showing fractionation or delayed components. Their activation time from surface ECG was defined as LFPat. RESULTS: Fifteen consecutive patients were included in the study. At EAM before ajmaline, 7 patients (46.7%) showed LFPs. All patients showed HFPs before and after ajmaline and LFPs after ajmaline. Mean HFPat (134.4 vs 65.3 ms, P
- Published
- 2021