16 results on '"Filippo Donati"'
Search Results
2. Sleep-wake habits and disorders in a series of 100 adult epilepsy patients—A prospective study
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Adrian M. Siegel, Filippo Donati, Daniel Zutter, Johannes Mathis, Claudio L. Bassetti, and Ramin Khatami
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Adult ,Male ,Sleep Wake Disorders ,Pediatrics ,medicine.medical_specialty ,Clinical Neurology ,Excessive daytime sleepiness ,Sleep complaints ,Body Mass Index ,Epilepsy ,Surveys and Questionnaires ,medicine ,Insomnia ,Humans ,Prospective Studies ,Restless legs syndrome ,Aged ,Sleep disorder ,Epworth Sleepiness Scale ,Sleep apnea ,General Medicine ,Middle Aged ,medicine.disease ,Sleep apnea syndrome ,Logistic Models ,Neurology ,Anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,Sleep onset ,Psychology ,Narcolepsy - Abstract
SummaryThe aim of the study was to assess sleep-wake habits and disorders and excessive daytime sleepiness (EDS) in an unselected outpatient epilepsy population. Sleep-wake habits and presence of sleep disorders were assessed by means of a clinical interview and a standard questionnaire in 100 consecutive patients with epilepsy and 90 controls. The questionnaire includes three validated instruments: the Epworth Sleepiness Scale (ESS) for EDS, SA-SDQ for sleep apnea (SA), and the Ullanlinna Narcolepsy Scale (UNS) for narcolepsy. Sleep complaints were reported by 30% of epilepsy patients compared to 10% of controls (p=0.001). The average total sleep time was similar in both groups. Insufficient sleep times were suspected in 24% of patients and 33% of controls. Sleep maintenance insomnia was more frequent in epilepsy patients (52% vs. 38%, p=0.06), whereas nightmares (6% vs. 16%, p=0.04) and bruxism (10% vs. 19%, p=0.07) were more frequent in controls. Sleep onset insomnia (34% vs. 28%), EDS (ESS ≥10, 19% vs. 14%), SA (9% vs. 3%), restless legs symptoms (RL-symptoms, 18% vs. 12%) and most parasomnias were similarly frequent in both groups. In a stepwise logistic regression model loud snoring and RL-symptoms were found to be the only independent predictors of EDS in epilepsy patients. In conclusion, sleep-wake habits and the frequency of most sleep disorders are similar in non-selected epilepsy patients as compared to controls. In epilepsy patients, EDS was predicted by a history of loud snoring and RL-symptoms but not by SA or epilepsy-related variables (including type of epilepsy, frequency of seizures, and number of antiepileptic drugs).
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- 2006
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3. Atorvastatin added to interferon beta for relapsing multiple sclerosis: 12-month treatment extension of the randomized multicenter SWABIMS trial
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Christian P Kamm, Marwan El-Koussy, Sebastian Humpert, Oliver Findling, Yuliya Burren, Guido Schwegler, Filippo Donati, Martin Müller, Felix Müller, Johannes Slotboom, Ludwig Kappos, Yvonne Naegelin, Heinrich P Mattle, and SWABIMS Study Group
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Male ,Atorvastatin ,lcsh:Medicine ,law.invention ,Randomized controlled trial ,law ,Clinical endpoint ,Single-Blind Method ,Prospective Studies ,lcsh:Science ,Multidisciplinary ,Middle Aged ,Treatment Outcome ,Tolerability ,Neurology ,Medicine ,Drug Therapy, Combination ,Female ,medicine.drug ,Interferon beta-1b ,Research Article ,Adult ,medicine.medical_specialty ,Drugs and Devices ,Multiple Sclerosis ,Combination therapy ,Clinical Research Design ,Immunology ,610 Medicine & health ,Immunomodulation ,Young Adult ,Multiple Sclerosis, Relapsing-Remitting ,Adjuvants, Immunologic ,Internal medicine ,medicine ,Humans ,Pyrroles ,Clinical Trials ,Adverse effect ,Biology ,business.industry ,Multiple sclerosis ,lcsh:R ,Odds ratio ,Interferon-beta ,medicine.disease ,Demyelinating Disorders ,Surgery ,Heptanoic Acids ,Clinical Immunology ,lcsh:Q ,business - Abstract
Background Statins have anti-inflammatory and immunomodulatory properties in addition to lipid-lowering effects. Objectives To report the 12-month extension of a phase II trial evaluating the efficacy, safety and tolerability of atorvastatin 40 mg/d added to interferon beta-1b (IFNB-1b) in relapsing-remitting multiple sclerosis (RRMS). Methods In the randomized, multicenter, parallel-group, rater-blinded core study, 77 RRMS patients started IFNB-1b. At month three they were randomized 1∶1 to receive atorvastatin 40 mg/d or not in addition to IFNB-1b until month 15. In the subsequent extension study, patients continued with unchanged medication for another 12 months. Data at study end were compared to data at month three of the core study. Results 27 of 72 patients that finished the core study entered the extension study. 45 patients were lost mainly due to a safety analysis during the core study including a recruitment stop for the extension study. The primary end point, the proportion of patients with new lesions on T2-weighted images was equal in both groups (odds ratio 1.926; 95% CI 0.265–14.0007; p = 0.51). All secondary endpoints including number of new lesions and total lesion volume on T2-weighted images, total number of Gd-enhancing lesions on T1-weighted images, volume of grey and white matter, EDSS, MSFC, relapse rate, number of relapse-free patients and neutralizing antibodies did not show significant differences either. The combination therapy was well tolerated. Conclusions Atorvastatin 40 mg/day in addition to IFNB-1b did not have any beneficial effects on RRMS compared to IFNB-1b monotherapy over a period of 24 months. Trial Registration ClinicalTrials.gov NCT01111656
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- 2014
4. Postanoxic alpha (theta) coma: a reappraisal of its prognostic significance
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Magdalena Berkhoff, Claudio L. Bassetti, and Filippo Donati
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Adult ,Male ,Resuscitation ,medicine.medical_specialty ,Time Factors ,Alpha (ethology) ,Neurological disorder ,Electroencephalography ,Evoked Potentials, Somatosensory ,Physiology (medical) ,medicine ,Humans ,Coma ,Hypoxia, Brain ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,Glasgow Outcome Scale ,Glasgow Coma Scale ,Middle Aged ,Prognosis ,medicine.disease ,Electric Stimulation ,Sensory Systems ,Surgery ,Neurology ,Somatosensory evoked potential ,Anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology - Abstract
Objectives : To appraise the controversial prognostic significance of postanoxic alpha or theta coma (ATC). Methods : We prospectively assessed 14 comatose patients with ATC after cardiac arrest by means of a protocol which included repeated clinical examinations, EEG, and median somatosensory evoked potentials (SEP). Good outcome was defined by the reappearance of cognition (Glasgow outcome scale 3–5) at any time during the 1 year follow-up. Results : Nine of 14 patients had a monotonous, frontally accentuated and areactive alpha (theta) EEG activity (complete ATC). In these patients ATC was recorded a mean of 47 h after resuscitation, the mean Glasgow coma scale (GCS) was 4 at 48 h, and early cortical SEPs were altered or absent in 5 of 7 patients. All nine patients died. In five of 14 patients the alpha (theta) EEG activity was either not monotonous, partially reactive or posteriorly dominant (incomplete ATC). In these patients ATC was recorded a mean of 43 h after resuscitation, the mean GCS was 8 at 48 h, and early cortical SEP were normal in 4 of 5 patients. Three of 5 patients regained cognition, two of them remained however dependent in activities of everyday life. Conclusions : This study and a review 283 cases of postanoxic ATC reported in the literature suggest the existence of incomplete and complete variants of postanoxic ATC. Whereas complete ATC is invariably associated with a poor outcome, full recovery is possible in patients with incomplete ATC. The combination of EEG, clinical, and SEP findings improves the prognostic accuracy of postanoxic ATC.
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- 2000
5. Developmental Background and Outcome in Patients with Nonepileptic Versus Epileptic Seizures: A Controlled Study
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Magdalena Berkhoff, Bogdan P. Radanov, Regula S. Briellmann, Filippo Donati, and Christian W. Hess
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Sick role ,Neurological disorder ,medicine.disease ,Placebo ,Comorbidity ,Psychogenic Seizure ,Epilepsy ,Neurology ,Convulsion ,medicine ,Psychogenic disease ,Neurology (clinical) ,medicine.symptom ,Psychology ,Clinical psychology - Abstract
Summary: Purpose: This study was designed to evaluate the relevance of developmental emotional stress factors, which are considered to influence emotional functioning, as contributing factors in the development of psychogenic symptoms. Methods: Ten patients with nonepileptic seizures (non-ESs) (frequently referred to as psychogenic seizures), in whom diagnosis had been confirmed by a placebo-infusion test (PT), and 10 control patients with complex partial seizures (ESs) were evaluated with regard to developmental background by using structured in-depth interviews performed by a single interviewer blinded to the diagnosis. In addition, outcome assessment in the non-ES group after PT was done. Results: There were no significant differences between groups in developmental psychosocial stress or in any single developmental stress factor. Six months after PT, the outcome was favorable in patients with non-ES: six were seizure free, and two had a considerable reduction in frequency of seizures. Conclusions: Our research indicates the following: (a) a high incidence of developmental stress factors and functional disturbances may be found in patients with non-ESs and ESs; (b) assessment of developmental emotional stress and functional disturbances as a basis for validating the diagonsis of non-ES should be treated with caution; (c) use of PT followed by supportive information about the nonepileptic origin of the attacks may have a positive therapeutic effect or help to introduce psychotherapeutic treatment. Key Words: Psychogenic seizures-Nonepileptic seizures-Developmental emotional stress-Outcome assessment-Placebo-infusion test.
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- 1998
6. Acute encephalitis in Swiss children: Aetiology and outcome
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Mario G. Bianchetti, Urs B. Schaad, Tobias Iff, F. Vassella, and Filippo Donati
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Male ,Pediatrics ,medicine.medical_specialty ,Pathology ,Cerebellar Ataxia ,Severity of Illness Index ,Cerebrospinal fluid ,Severity of illness ,medicine ,Humans ,Retrospective Studies ,Cerebellar ataxia ,business.industry ,Acute cerebellar ataxia ,Retrospective cohort study ,General Medicine ,medicine.disease ,Treatment Outcome ,Acute Disease ,Pediatrics, Perinatology and Child Health ,Acute encephalitis ,Etiology ,Encephalitis ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Switzerland - Abstract
Since published data on the course and prognosis of encephalitis in Central Europe is limited, we retrospectively evaluated 104 children with either acute strict sense encephalitis (n = 80) or acute cerebellar ataxia (n = 24) treated at the Department of Pediatrics, University of Bern, Switzerland, between 1980 and 1991. Of the 80 patients with strict sense encephalitis, four (5%) died acutely and 28 (36%) of 78 followed up had sequelae - eight patients with severe, six with moderate and 14 with mild sequelae. Young age and seizures were shown to correlate with poor outcome. Among the 24 patients with acute cerebellar ataxia, there was no fatal outcome and none developed severe residua, but six had mild and one had moderate sequelae. Initial cerebrospinal fluid white cell count was significantly higher in these children with sequelae compared with those without any sequelae after acute cerebellar ataxia.
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- 1998
7. Apnoeic attacks as an isolated manifestation of epileptic seizures in infants
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Filippo Donati, Gian Paolo Ramelli, F. Vassella, and Mario G. Bianchetti
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Apnea ,Theta activity ,Electroencephalography ,Diagnosis, Differential ,Epilepsy ,Rhythm ,Heart Rate ,Pregnancy ,Heart rate ,medicine ,Humans ,Ictal ,Apnoeic attacks ,Psychomotor learning ,medicine.diagnostic_test ,Infant, Newborn ,Infant ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Temporal Lobe ,Frontal Lobe ,nervous system diseases ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Female ,Neurology (clinical) ,Atrophy ,Psychology - Abstract
Apnoea as an isolated manifestation of seizures is well described in neonates but is only occasionally observed in infants. We present data from four infants, with apnoea as the sole manifestation of seizures, documented by polygraphic ictal electroencephalogram (EEGC) and video recording. The four infants, after normal pregnancy and delivery at term, showed the first apnoea at the age of 2-11 months. The interictal EEG was normal. The ictal EEG and video recording showed in all infants a focal rhythmic alpha or theta activity with or without generalization, which lasted 40-120 seconds. The apnoea appeared a few seconds after the beginning of rhythmic activity and the heart rate remained unchanged during the apnoea. At 2 years' follow-up, three children are seizure-free under anti-epileptic therapy with normal psychomotor development in two, and a slight delay in the third infant. The fourth child has partial seizures and is severely retarded.
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- 1998
8. Onset-age dependent MRI based hippocampal volume asymmetries in intractable partial complex temporal lobe epilepsy
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Filippo Donati, Regula S. Briellmann, Gerhard Schroth, C. W. Hess, Christoph Ozdoba, and K. Gutbrod
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Neuropsychology ,Magnetic resonance imaging ,Age dependent ,Hippocampal formation ,medicine.disease ,Temporal lobe ,Epilepsy ,Neurology ,Internal medicine ,medicine ,Cardiology ,Hippocampal volume ,Statistical analysis ,Neurology (clinical) ,business ,Psychiatry - Abstract
The purpose of this study was to determine whether the age at onset of temporal lobe epilepsy influences hippocampal volume. Fifteen right-handed patients with medically intractable partial complex epilepsy of temporal origin were studied in quantified magnetic resonance imaging (MRI) and neuropsychological tests. In seven patients (mean age: 24 years) epilepsy began before the age of three (? YOUNG), in eight patients (mean age: 29 y) after the age of three (= OLDER). Education, social integration, duration of epilepsy and seizure frequency were equal in YOUNG and OLDER. The mean hippocampal volume, after normalization to total intracranial volume was for the right and for the left side smaller in YOUNG than in OLDER (p ≤ 0.02). The side-to-side asymmetry of absolute hippocampal volume was in patients with left-side focus more pronounced in YOUNG than in OLDER (p < 0.03). The number of patients with right-side focus was too small for statistical analysis. Results of neuropsychological testing showed no significant differences between YOUNG and OLDER. Onset-age of epilepsy before three years is associated with a higher risk of bilateral hippocampal hypotrophy and unilateral hippocampal asymmetry. Performance in neuropsychological testing seems not to be significantly influenced by hippocampal volume or age at onset.
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- 1997
9. Factors predicting the risk of relapse after antiepileptic drug discontinuation in children with partial seizures
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F. Vassella, Ralph I. Hassink, Filippo Donati, and Hans Jung
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Male ,Pediatrics ,medicine.medical_specialty ,Neurological examination ,Electroencephalography ,Epilepsy ,Recurrence ,Risk Factors ,Epidemiology ,medicine ,Humans ,Relapse risk ,Psychomotor learning ,medicine.diagnostic_test ,partial seizures ,business.industry ,medicine.disease ,Substance Withdrawal Syndrome ,Discontinuation ,Child, Preschool ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Anticonvulsants ,Female ,business - Abstract
The purpose of this study is to identify possible factors which could influence the seizure recurrence after anti-epileptic drug (AED) withdrawal in children with partial epilepsy. AED was discontinued in 82 children who had been free of partial epileptic seizures for 2.0–11.0 years (mean 4.7 years). Twenty-four patients (29.3%) had a relapse from a few days to 6.1 years (mean 1.2 years) after AED discontinuation. Significantly more common in children who relapsed were: younger age at beginning of AED withdrawal, occurrence of complicated febrile convulsions (5/24 vs 1/58,P
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- 1995
10. Atorvastatin added to interferon beta for relapsing multiple sclerosis: a randomized controlled trial
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Felix Müller, Filippo Donati, Yvonne Naegelin, Ludwig Kappos, Marwan El-Koussy, Yuliya Burren, Oliver Findling, Christian P. Kamm, Dagmar Schött, Johannes Slotboom, Guido Schwegler, Barbara Tettenborn, Sebastian Humpert, Ferdinand von Bredow, Norbert Goebels, Heinrich Mattle, and Martin Müller
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Atorvastatin ,Clinical Neurology ,Gastroenterology ,law.invention ,Multiple sclerosis ,Young Adult ,Multiple Sclerosis, Relapsing-Remitting ,Pharmacotherapy ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,Pyrroles ,Single-Blind Method ,Prospective Studies ,Prospective cohort study ,Original Communication ,business.industry ,Interferon beta-1b ,Interferon-beta ,Odds ratio ,Middle Aged ,Interferon beta ,medicine.disease ,Surgery ,Treatment Outcome ,Neurology ,Heptanoic Acids ,Drug Therapy, Combination ,Female ,Randomized clinical trial ,Neurology (clinical) ,business ,medicine.drug - Abstract
Statins have anti-inflammatory and immunomodulatory properties in addition to lipid-lowering effects. The present study evaluated the effect of atorvastatin added to interferon beta-1b in multiple sclerosis (MS) in a multicenter, randomized, parallel-group, rater-blinded study performed in eight Swiss hospitals. Seventy-seven patients with relapsing-remitting MS started interferon beta-1b every other day. After 3 months, they were randomized 1:1 to receive atorvastatin 40 mg/day or not in addition to interferon beta-1b until month 15. The primary endpoint was the proportion of patients with new lesions on T2-weighted images at month 15 compared to baseline at month three. At study end, the proportion of patients with new lesions on T2-weighted images was equal in both groups (odds ratio 1.14; 95 % CI 0.36–3.56; p = 0.81). All predefined secondary endpoints including number of new lesions and total lesion volume on T2-weighted images, total number of new Gd-enhancing lesions on T1-weighted images, total brain volume, volume of grey matter, volume of white matter, EDSS, MSFC, relapse rate, time to first relapse, number of relapse-free patients and neutralizing antibodies did not show any significant differences (all p values >0.1). Transient elevations of liver enzymes were more frequent with atorvastatin (p = 0.02). In conclusion, atorvastatin 40 mg/day in addition to interferon beta-1b did not have a beneficial effect on relapsing-remitting MS compared to interferon beta-1b monotherapy over a 12-month period. Electronic supplementary material The online version of this article (doi:10.1007/s00415-012-6513-7) contains supplementary material, which is available to authorized users.
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- 2012
11. Effects of oxcarbazepine on cognitive function in children and adolescents with partial seizures
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Filippo Donati, Jaume Campistol, Yvonne Sturm, Albert P. Aldenkamp, G Rapatz, M Daehler, and Giuseppe Gobbi
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Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Oxcarbazepine ,Risk Assessment ,law.invention ,Central nervous system disease ,Epilepsy ,Cognition ,Randomized controlled trial ,law ,Risk Factors ,medicine ,Humans ,Child ,Valproic Acid ,Carbamazepine ,medicine.disease ,Prognosis ,Cognitive test ,Europe ,Drug Combinations ,Treatment Outcome ,El Niño ,Anesthesia ,Anticonvulsants ,Female ,Neurology (clinical) ,Epilepsies, Partial ,Psychology ,Cognition Disorders ,medicine.drug - Abstract
The authors investigated the effect of oxcarbazepine on cognitive function in children and adolescents (6 to younger than 17 years of age) with newly diagnosed partial seizures in an open-label comparison with standard antiepileptic drug therapy (carbamazepine and valproate). No differences in cognitive tests were observed between oxcarbazepine and carbamazepine/valproate over a 6-month treatment period.
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- 2006
12. Changes on diffusion-weighted MRI with focal motor status epilepticus: case report
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Claudio L. Bassetti, O Zeller, Pascal Senn, Karl-Olof Lövblad, Filippo Donati, Gerhard Schroth, and D Zutter
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Male ,Pathology ,medicine.medical_specialty ,Brain Edema ,Status epilepticus ,Electroencephalography ,ddc:616.0757 ,Status Epilepticus ,Atrophy ,Parenchyma ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,medicine.diagnostic_test ,Focal status epilepticus ,business.industry ,Epilepsia partialis continua ,Diffusion weighted imaging ,Middle Aged ,Hand ,medicine.disease ,Pathophysiology ,Diffusion Magnetic Resonance Imaging ,Face ,Arm ,Neurology (clinical) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Diffusion MRI - Abstract
Transient imaging abnormalities, including changes on diffusion-weighted imaging (DWI), may be seen in focal status epilepticus. The changes on DWI provide am insight into the pathophysiology. We report a 53-year-old man with focal motor status epilepticus involving the left hand, arm and face with focal slowing on EEG. The apparent diffusion coefficients (ADC) were higher in the affected hemisphere than on the other side. At 10 days and 6 weeks after the end of the seizures, we saw normal ADCs and atrophy of the affected hemisphere. We conclude that the MRI findings indicate both cytotoxic and vasogenic oedema during seizure activity and subsequent loss of brain parenchyma.
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- 2003
13. Diffusion and perfusion MRI for the localisation of epileptogenic foci in drug-resistant epilepsy
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Bruno Weder, Marwan El-Koussy, Claus Kiefer, Gerhard Schroth, Kaspar Schindler, Heiniger P, Luigi Mariani, Michael Wissmeyer, Helmut Oswald, Filippo Donati, and Karl-Olof Lövblad
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Adult ,Male ,medicine.medical_specialty ,Neurology ,Adolescent ,Drug Resistance ,Single-photon emission computed tomography ,Diffusion ,Epilepsy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ictal ,Neuroradiology ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Drug Resistant Epilepsy ,Magnetic Resonance Imaging ,Perfusion ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Emission computed tomography - Abstract
Drug-resistant epilepsy is an important clinical challenge, both diagnostically and therapeutically. More and more surgical options are being considered, but precise presurgical assessment is necessary. We prospectively studied eight patients with drug-resistant epilepsy, who underwent clinical examination, single photon emission computed tomography (SPECT) and interictal MRI, including diffusion- and perfusion-weighted echoplanar sequences. Lesions suspected on SPECT of being epileptogenic showed mild hypoperfusion, while the diffusion-weighted MRI (DWI) revealed increased apparent diffusion coefficients relative to the other side. However, these abnormalities were not visible on the corresponding maps. We showed that DWI and perfusion-weighted MRI could be used confirm the characteristics and site of an epileptogenic area in patients with drug-resistant epilepsy.
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- 2001
14. Hyperperfusion of anterior cingulate gyrus in a case of paroxysmal nocturnal dystonia
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J. Fritschi, Bruno Weder, Karl-Olof Lövblad, Claudio L. Bassetti, Michael Wissmeyer, Filippo Donati, Roland Wiest, Heidemarie Gast, K. Meyer, Kaspar Schindler, and M. Kollar
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Adult ,medicine.medical_specialty ,Neurological disorder ,Electroencephalography ,Ictal-Interictal SPECT Analysis by SPM ,Gyrus Cinguli ,Anterior cingulate gyrus ,Gyrus ,Internal medicine ,medicine ,Humans ,Ictal ,Monitoring, Physiologic ,Dystonia ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,Nocturnal Paroxysmal Dystonia ,medicine.disease ,nervous system diseases ,medicine.anatomical_structure ,nervous system ,Cardiology ,Paroxysmal nocturnal dystonia ,Female ,Neurology (clinical) ,Psychology ,Neuroscience - Abstract
The authors report the clinical, EEG, and SPECT findings of a patient with nocturnal paroxysmal dystonia. Ictal and interictal scalp EEG showed epileptiform activity over both frontal lobes. Subtraction ictal SPECT co-registered to MRI indicated a bilateral significant hyperperfusion in the anterior part of the cingulate gyrus. These results support earlier electrophysiologic investigations by others suggesting that anterior cingulate epilepsy may manifest as nocturnal paroxysmal dystonia, and illustrate the usefulness of computer-assisted SPECT analysis.
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- 2001
15. SPECT during sleepwalking
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Bruno Weder, Claudio L. Bassetti, Peter Wielepp, Silvano Vella, and Filippo Donati
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Sleep disorder ,medicine.medical_specialty ,Dissociation (neuropsychology) ,medicine.diagnostic_test ,business.industry ,General Medicine ,Polysomnography ,Somnambulism ,Single-photon emission computed tomography ,medicine.disease ,Confusional arousal ,Arousal ,Surgery ,Sleepwalking ,medicine ,business ,Neuroscience - Abstract
Sleepwalking is a dissociation between body sleep and mind sleep. We report single photon emission computed tomography (SPECT) in a man with a history of sleepwalking. Our findings suggest that this dissociation arises from activation of thalamocingulate pathways and persisting deactivation of other thalamocortical arousal systems.
- Published
- 2000
16. 128 Sleepwalking and SPECT studies
- Author
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Claudio L. Bassetti, P. Wielepp, S. Vella, Bruno Weder, and Filippo Donati
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medicine.medical_specialty ,Sleepwalking ,business.industry ,Pediatrics, Perinatology and Child Health ,Medicine ,Neurology (clinical) ,General Medicine ,business ,medicine.disease ,Psychiatry - Published
- 1999
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