6 results on '"Fazil, Ahmad"'
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2. Phytochemical and Pharmacological Screening for Antidiabetic Activity of Salvia aegyptiaca L. Ethanolic Leaves Extract
- Author
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Abdul Saleem Mohammad, Rasheed Ahemad Shaik, Abeer Mohammed Al Subaie, Fazil Ahmad, and J. Muthu Mohamed
- Subjects
chemistry.chemical_classification ,Traditional medicine ,Chemistry ,Insulin ,medicine.medical_treatment ,Glycoside ,medicine.disease ,food.food ,Terpenoid ,chemistry.chemical_compound ,Tolbutamide ,food ,Salvia aegyptiaca ,Phytochemical ,Alloxan ,Diabetes mellitus ,medicine ,medicine.drug - Abstract
Diabetes mellitus is a common metabolic disorder of carbohydrate, fat, and protein, which results in high levels of glucose in the body after a meal or fasting. This disease is caused by the absence or reduction of insulin secretion. Accordingly, diabetes is usually classified into two types, Type 1(IDDM) and Type II (NIDDM). The aim of the present study is to carry the phytochemical analysis and antidiabetic activity of Salvia aegyptiaca L ethanolic leaves extract. Phytochemical study was carried out by standard methods, shows the presence of various phytochemical constituents such as, phenols, flavonoids, steroids, proteins, glycosides, carbohydrates, lipids, alkaloids, tannins and terpenoids, while saponins shown to be absent. Antidiabetic activity of Salvia aegyptiaca L were carried out in both normoglycemic and diabetic induced rats. Normoglycemic animal group were fed with ethanolic leaves extract of Salvia aegyptiaca L at a dose of 250mg/kg and 500mg/kg alone for 14days, showed decrease in blood glucose level. In diabetic animal group the rats were made diabetic by intraperitoneal(i.p) injection of 100 mg/kg alloxan monohydrate, then followed by administration of ethanolic leaves extract of Salvia aegyptiaca (250mg/kg and 500mg/kg) and standard Tolbutamide (50mg/kg,p.o) for14 days. The results of the diabetic induced group also showed decrease in glucose levels. The results of the current investigation demonstrate that various phytochemical present in Salvia aegyptiaca L ethanolic leaves extracts, might be responsible for antidiabetic effect, due to its known antioxidant property.
- Published
- 2020
- Full Text
- View/download PDF
3. Phytochemical and Pharmacological Screening for Antidiabetic Activity of Salvia aegyptiaca L. Ethanolic Leaves Extract
- Author
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Fazil Ahmad
- Subjects
chemistry.chemical_classification ,History ,Antioxidant ,Polymers and Plastics ,Traditional medicine ,medicine.medical_treatment ,Glycoside ,medicine.disease ,Industrial and Manufacturing Engineering ,Terpenoid ,food.food ,chemistry.chemical_compound ,food ,Tolbutamide ,Salvia aegyptiaca ,chemistry ,Phytochemical ,Alloxan ,Diabetes mellitus ,medicine ,Business and International Management ,medicine.drug - Abstract
Diabetes mellitus is a common metabolic disorder of carbohydrate, fat, and protein, which results in high levels of glucose in the body after a meal or fasting. This disease is caused by the absence or reduction of insulin secretion. Accordingly, diabetes is usually classified into two types, Type 1(IDDM) and Type II (NIDDM). The aim of the present study is to carry the phytochemical analysisand antidiabetic activity of Salvia aegyptiaca L ethanolic leaves extract. Phytochemical study was carried out by standard methods, shows the presence of various phytochemical constituents such as, phenols, flavonoids, steroids, proteins, glycosides, carbohydrates, lipids, alkaloids, tannins and terpenoids, while saponins shown to be absent. Antidiabetic activity of Salvia aegyptiaca L were carried out in both normoglycemic and diabetic induced rats. Normoglycemic animal group were fed with ethanolic leaves extract of Salvia aegyptiaca L at a dose of 250mg/kg and 500mg/kg alone for 14days, showed decrease in blood glucose level. In diabetic animal group the rats were made diabetic by intraperitoneal(i.p) injection of 100 mg/kg alloxan monohydrate, then followed by administration of ethanolic leaves extract of Salvia aegyptiaca (250mg/kg and 500mg/kg) and standard Tolbutamide (50mg/kg,p.o) for14 days. The results of the diabetic induced group also showed decrease in glucose levels. The results of the current investigation demonstrate that various phytochemical present in Salvia aegyptiaca L ethanolic leaves extracts, might be responsible for antidiabetic effect, due to its known antioxidant property.
- Published
- 2021
- Full Text
- View/download PDF
4. Effect of novel leukemia mutations (K75EE222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies
- Author
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Balu Kamaraj, Krishna Mohan Surapaneni, Abeer M. Al-Subaie, Fazil Ahmad, and Khaldoon Alsamman
- Subjects
Leukemia ,Tumor suppressor gene ,Cellular differentiation ,Mutant ,General Medicine ,DNA ,Molecular Dynamics Simulation ,medicine.disease ,Cell biology ,chemistry.chemical_compound ,IRF1 ,chemistry ,Structural Biology ,Docking (molecular) ,Mutation ,medicine ,Coding region ,Humans ,Molecular Biology ,Interferon Regulatory Factor-1 - Abstract
Interferon regulatory factor 1 (IRF-1) plays a vital role in cell proliferation and cell differentiation by acting as a tumor suppressor gene and its role is linked to various types of cancers, including leukemia and pre-leukemia myelodysplasia. Mutations in the coding region of the IRF-1 are likely to influence the IRF-1 and its DNA binding affinity. The molecular mechanism of the DNA recognition with the IRF-1 protein upon mutations is still unknown. In this study, we have elucidated the structural and functional behavior of the wild-type and mutant (K75E and E222K) IRF-1 proteins and their corresponding molecular mechanisms with DNA recognition at the molecular level, using molecular dynamics simulations. Furthermore, we also applied the docking approach to examine the binding between the IRF-1 protein and DNA upon mutations. This study evidently explains that, due to mutations, the IRF-1 structure loses its stability and becomes more flexible than the wild-type protein. This structural loss might affect IRF-1-DNA interaction and lead to the inhibition of cancer suppression. Identifying the effects of IRF-1 at the molecular level will be beneficial for designing drugs for IRF-1 associated cancers. These drugs should be designed so that they can help reactivate the IRF-1 function, by increasing the transcriptional activity, to treat leukemia.
- Published
- 2020
5. Improving immunization in Afghanistan: results from a cross-sectional community-based survey to assess routine immunization coverage
- Author
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Sardar M. Parwiz, Raveesha R. Mugali, Najibullah Safi, Sherin Varkey, Ariel Higgins-Steele, Fazil Ahmad, and Farooq Mansoor
- Subjects
Male ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,030231 tropical medicine ,Psychological intervention ,Measle Vaccine ,Measles ,Oral Poliovirus Vaccine ,03 medical and health sciences ,0302 clinical medicine ,Routine Immunization ,Residence Characteristics ,Environmental health ,Measle ,medicine ,Humans ,030212 general & internal medicine ,Immunization Schedule ,Immunization Programs ,business.industry ,Mortality rate ,Public health ,lcsh:Public aspects of medicine ,Vaccination ,Afghanistan ,Public Health, Environmental and Occupational Health ,Infant ,Immunization Coverage ,lcsh:RA1-1270 ,medicine.disease ,Poliomyelitis ,Cross-Sectional Studies ,Immunization ,Female ,Biostatistics ,business ,Research Article - Abstract
Background Despite progress in recent years, Afghanistan is lagging behind in realizing the full potential of immunization. The country is still endemic for polio transmission and measles outbreaks continue to occur. In spite of significant reductions over the past decade, the mortality rate of children under 5 years of age continues to remain high at 91 per 1000 live births. Methods The study was a descriptive community-based cross sectional household survey. The survey aimed to estimate the levels of immunization coverage at national and province levels. Specific objectives are to: establish valid baseline information to monitor progress of the immunization program; identify reasons why children are not immunized; and make recommendations to enhance access and quality of immunization services in Afghanistan. The survey was carried out in all 34 provinces of the country, with a sample of 6125 mothers of children aged 12โ23 months. Results Nationally, 51% of children participating in the survey received all doses of each antigen irrespective of the recommended date of immunization or recommended interval between doses. About 31% of children were found to be partially vaccinated. Reasons for partial vaccination included: place to vaccinate child too far (23%), not aware of the need of vaccination (17%), no faith in vaccination (16%), mother was too busy (15%), and fear of side effects (11%). Conclusion The innovative mechanism of contracting out delivery of primary health care services in Afghanistan, including immunization, to non-governmental organizations is showing some positive results in quickly increasing coverage of essential interventions, including routine immunization. Much ground still needs to be covered with proper planning and management of resources in order to improve the immunization coverage in Afghanistan and increase survival and health status of its children.
- Published
- 2017
- Full Text
- View/download PDF
6. Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats
- Author
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Abeer M. Al-Subaie, Saleha Ahmed, Fazil Ahmad, Nishat Ahmed, and Inshah Ahmed
- Subjects
chemistry.chemical_compound ,Emblica officinalis ,chemistry ,Uterine fibroids ,Monosodium glutamate ,business.industry ,medicine ,Pharmacology (medical) ,Pharmacology ,medicine.disease ,business ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) - Published
- 2020
- Full Text
- View/download PDF
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