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Your search keyword '"D.L. DeMeo"' showing total 20 results
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20 results on '"D.L. DeMeo"'

2. Mortality, Chronic Pain, and Opiate Use in the COPDGene Cohort

Author

G.L. Kinney, John E. Hokanson, Karin F. Hoth, B.J. Make, J.D. Crapo, D.L. DeMeo, Kendra A. Young, E.A. Regan, M.F. Ragland, and Katherine E Lowe

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Cohort, medicine, Chronic pain, Opiate, business, medicine.disease
Published
2020
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9. Genome-Wide Discovery of Modifiers of Lung Function in Severe Alpha-1 Antitrypsin Deficiency

Author

James K. Stoller, D.L. DeMeo, Mark L. Brantly, Auyon J. Ghosh, Alice M Turner, Stephen I. Rennard, Michael H. Cho, Edward K. Silverman, Robert A. Stockley, Brian D. Hobbs, C Strange, Gerard M. Turino, Noel G. McElvaney, Edward Eden, Dandi Qiao, E.J. Campbell, Alan F. Barker, and Robert A. Sandhaus

Subjects
Alpha 1-antitrypsin deficiency, Immunology, medicine, Biology, medicine.disease, Genome, Lung function
Published
2020
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11. X Chromosome Genetic Associations in COPD

Author

Christian E. Lange, Amund Gulsvik, David A. Lomas, Michael H. Cho, Lystra P. Hayden, Edward K. Silverman, Per Bakke, D.L. DeMeo, Nan M. Laird, and T.H. Beaty

Subjects
Genetics, COPD, medicine, Biology, medicine.disease, X chromosome
Published
2019
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14. Maternal alcohol consumption during pregnancy and offspring epigenome-wide DNA methylation: findings from six general population-based birth cohorts

Author

Sarah E. Reese, Sheryl L. Rifas-Shiman, Marie-France Hivert, Oken E, Liesbeth Duijts, Andrea A. Baccarelli, Gemma C Sharp, Luisa Zuccolo, Nystad W, Augusto A. Litonjua, Kimberley Burrows, Ryan Arathimos, Ching-Ti Liu, Leanne K. Küpers, Jaddoe, Magnus Mc, Christian M. Page, Harold Snieder, Shanshan Zhao, Corpeleijn E, London Sj, Caroline L Relton, D.L. DeMeo, and Janine F. Felix

Subjects
Genetics, Pregnancy, education.field_of_study, Offspring, Population, Physiology, Epigenome, Biology, medicine.disease, Differentially methylated regions, CpG site, DNA methylation, medicine, Epigenetics, education
Abstract

Some evidence suggests that light-to-moderate alcohol consumption during pregnancy is associated with adverse outcomes in the offspring, but the precise biological mechanisms underlying such associations are currently unknown. Epigenetic modifications have been suggested as one potential explanation.Within the Pregnancy and Childhood Epigenetics (PACE) consortium, we performed meta-analysis to combine information from six population-based birth cohort studies to investigate DNA methylation at over 450,000 sites in the cord blood of newborns differentially exposed to alcohol in utero. We were primarily interested in the effects of sustained consumption throughout pregnancy (data available for five cohorts, 3,075 mother-child pairs), which represents a prolonged prenatal exposure to alcohol, but we also explored binge-drinking and timing-specific exposures. In addition to looking for differential methylation at individual CpG sites, we also used two different methods, Comb-P and DMRcate, to identify differentially methylated regions (DMRs).We found no strong evidence of association between any of our alcohol exposure measures and DNA methylation at any individual CpG site. Using Comb-P, we identified 19 DMRs in the offspring of mothers who drank throughout pregnancy compared to the offspring of mothers who gave up drinking at the start of pregnancy, but these were not validated using DMRcate.In this multi-cohort study of the general population we found no evidence that maternal alcohol consumption during pregnancy is associated with offspring cord blood DNA methylation, which is in stark contrast to the multiple, strong associations that previous studies have found for maternal smoking. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure and a more global assessment of genomic DNA methylation might show evidence of association.

Published
2017
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15. Genome-wide association study of smoking behaviours in patients with COPD

Author

Byron Thomashow, John D. Newell, Philip Alapat, Timothy Bresnahan, Matt Budoff, Richard Casaburi, Julie C. Yates, Amund Gulsvik, Kalpalatha K. Guntupalli, Elizabeth Guy, Paul J. Friedman, Venkata Bandi, Ella A. Kazerooni, Lisa D. Edwards, Adam L. Friedlander, Mark T. Dransfield, Amir Sharafkhaneh, Jørgen Vestbo, Robert Brown, Charlene McEvoy, Wayne H. Anderson, John E. Hokanson, Geoffrey McLennan, Dennis E. Niewoehner, A. James Mamary, David A. Lomas, Fernando J. Martinez, Roham Darvishi, H. Page McAdams, Antonio Anzueto, Terri H. Beaty, Hirani Kamal, Michael H. Cho, Brad H. Thompson, Aditi Satti, Nicola A. Hanania, Christine H. Wendt, Nadia Hansel, Harvey O. Coxson, Tadashi Allen, Ruth Tal-Singer, Mateusz Siedlinski, Robert M. Steiner, Russell P. Bowler, Sandra G. Adams, Katharine Knobil, Per Bakke, Hrudaya Nath, D.L. DeMeo, Joel L. Weissfeld, Gloria Westney, Janos Porszasz, Kathryn L. Rice, Edwin J. R. van Beek, Graham Barr, John H.M. Austin, Stephen I. Rennard, William MacNee, Quentin Anderson, Eugene Berkowitz, Dwight C. Look, Carlos Orozco, William C. Bailey, Nathaniel Marchetti, Carl R. Fuhrman, James D. Crapo, Hans Fischer, Victor Kim, Xiangyang Kong, Charles Trinh, Joe Ramsdell, George Washko, Richard Rosiello, Joyce Schroeder, Joseph H. Tashjian, Frank C. Sciurba, Mustafa A. Atik, Gerard J. Criner, Edwin K. Silverman, MeiLan K. Han, Marilyn Foreman, Jeffrey L. Curtis, Antara Mallampalli, Mario E. Ruiz, Robert Wise, C.P. Hersh, Lacey Washington, Gregory Diette, Neil R. MacIntyre, David A. Lynch, Francine Jacobson, Jessica Bon, Chandra Dass, Pulmonologie, RS: CAPHRI School for Public Health and Primary Care, and RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Genotype, medicine.medical_treatment, Genome-wide association study, Single-nucleotide polymorphism, Dopamine beta-Hydroxylase, Polymorphism, Single Nucleotide, Article, Cytochrome P-450 CYP2A6, Pulmonary Disease, Chronic Obstructive, Internal medicine, Epidemiology, medicine, Humans, SNP, Comparative Study, Genetic Predisposition to Disease, Aged, Genetic association, Genetics, COPD, clinical trial, phase II, business.industry, Incidence, Smoking, Age Factors, DNA, Middle Aged, medicine.disease, United States, Obstructive lung disease, multicenter study, Randomized controlled trial, Smoking cessation, Female, Smoking Cessation, Aryl Hydrocarbon Hydroxylases, business, Genome-Wide Association Study
Abstract

Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) and a dopamine beta-hydroxylase (DBH) locus associated with smoking cessation in multiple populations. Objective To identify SNPs associated with lifetime average and current CPD, age at smoking initiation, and smoking cessation in patients with COPD. Methods GWAS were conducted in four independent cohorts encompassing 3441 ever-smoking patients with COPD (Global Initiative for Obstructive Lung Disease stage II or higher). Untyped SNPs were imputed using the HapMap (phase II) panel. Results from all cohorts were meta-analysed. Results Several SNPs near the HLA region on chromosome 6p21 and in an intergenic region on chromosome 2q21 showed associations with age at smoking initiation, both with the lowest p=2x10(-7). No SNPs were associated with lifetime average CPD, current CPD or smoking cessation with p

Published
2011
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