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1. AI-Based Quantification of Planned Radiation Therapy Dose to Cardiac Structures and Coronary Arteries in Patients With Breast Cancer

Author: Max A. Viergever, Steffen Bruns, Jelmer M. Wolterink, Helena M. Verkooijen, Tim Leiner, Sanne G. M. van Velzen, Ivana Išgum, Biomedical Engineering and Physics, Graduate School, ACS - Atherosclerosis & ischemic syndromes, Radiology and Nuclear Medicine, ANS - Brain Imaging, ACS - Heart failure & arrhythmias, IvI Research (FNWI), TechMed Centre, Digital Society Institute, and Mathematics of Imaging & AI
Subjects: Cancer Research, medicine.medical_treatment, Breast Neoplasms, Breast cancer, medicine, Humans, Radiology, Nuclear Medicine and imaging, Segmentation, In patient, 22/1 OA procedure, Radiation treatment planning, Radiation, business.industry, Heart, medicine.disease, Coronary Vessels, Radiation therapy, Coronary arteries, medicine.anatomical_structure, Oncology, Cardiac chamber, Female, Neural Networks, Computer, Nuclear medicine, business, Tomography, X-Ray Computed, Artery
Abstract: Purpose: The purpose of this work is to develop and evaluate an automatic deep learning method for segmentation of cardiac chambers and large arteries, and localization of the 3 main coronary arteries in radiation therapy planning on computed tomography (CT). In addition, a second purpose is to determine the planned radiation therapy dose to cardiac structures for breast cancer therapy.Methods and Materials: Eighteen contrast-enhanced cardiac scans acquired with a dual-layer-detector CT scanner were included for method development. Manual reference annotations of cardiac chambers, large arteries, and coronary artery locations were made in the contrast scans and transferred to virtual noncontrast images, mimicking noncontrast-enhanced CT. In addition, 31 noncontrast-enhanced radiation therapy treatment planning CTs with corresponding dose-distribution maps of breast cancer cases were included for evaluation. For reference, cardiac chambers and large vessels were manually annotated in two 2-dimensional (2D) slices per scan (26 scans, totaling 52 slices) and in 3-dimensional (3D) scan volumes in 5 scans. Coronary artery locations were annotated on 3D imaging. The method uses an ensemble of convolutional neural networks with 2 output branches that perform 2 distinct tasks: (1) segmentation of the cardiac chambers and large arteries and (2) localization of coronary arteries. Training was performed using reference annotations and virtual noncontrast cardiac scans. Automatic segmentation of the cardiac chambers and large vessels and the coronary artery locations was evaluated in radiation therapy planning CT with Dice score (DSC) and average symmetrical surface distance (ASSD). The correlation between dosimetric parameters derived from the automatic and reference segmentations was evaluated with R2.Results: For cardiac chambers and large arteries, median DSC was 0.76 to 0.88, and the median ASSD was 0.17 to 0.27 cm in 2D slice evaluation. 3D evaluation found a DSC of 0.87 to 0.93 and an ASSD of 0.07 to 0.10 cm. Median DSC of the coronary artery locations ranged from 0.80 to 0.91. R2 values of dosimetric parameters were 0.77 to 1.00 for the cardiac chambers and large vessels, and 0.76 to 0.95 for the coronary arteries.Conclusions: The developed and evaluated method can automatically obtain accurate estimates of planned radiation dose and dosimetric parameters for the cardiac chambers, large arteries, and coronary arteries.
Published: 2022

2. Long-term stoma-related reinterventions after anterior resection for rectal cancer with or without anastomosis: population data from the Dutch snapshot study

Author: Hazen, S. J. A., Vogel, I., Borstlap, W. A. A., Dekker, J. W. T., Tuynman, J. B., Tanis, P. J., Kusters, M., Deijen, C. L., den Dulk, M., Bonjer, H. J., van de Velde, C. J., Aalbers, A. G. J., Acherman, Y., Algie, G. D., von Geusau, B. Alting, Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., de Mik, S. M. L., van Duijvendijk, P., Gooszen, J. A. H., Hoogland, P., Lamme, B., Marres, C. C., Musters, G. D., van Rossem, C. C., Schreuder, A. M., Swank, H. A., van beek, S. C., van Westreenen, H. L., Westerduin, E., Surgery, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, APH - Global Health, APH - Quality of Care, CCA - Cancer biology and immunology, Anatomy and neurosciences, General practice, Obstetrics and gynaecology, VU University medical center, Amsterdam Reproduction & Development (AR&D), Graduate School, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Subjects: medicine.medical_specialty, Colorectal cancer, Anastomosis, medicine.medical_treatment, digestive system, Stoma, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], medicine, Rectal cancer, business.industry, Gastroenterology, Colostomy, Permanent stoma, Anterior resection, medicine.disease, digestive system diseases, Colorectal surgery, Surgery, medicine.anatomical_structure, surgical procedures, operative, Sphincter, Hartmann’s procedure, business, Cohort study, Abdominal surgery
Abstract: Item does not contain fulltext BACKGROUND: The aim of this study was to analyze the stoma-related reinterventions, complications and readmissions after an anterior resection for rectal cancer, based on a cross-sectional nationwide cohort study with 3-year follow-up. METHODS: Rectal cancer patients who underwent a resection with either a functional anastomosis, a defunctioned anastomosis, or Hartmann's procedure (HP) with an end colostomy in 2011 in 71 Dutch hospitals were included. The primary outcome was number of stoma-related reinterventions. RESULTS: Of the 2095 patients with rectal cancer, 1400 patients received an anterior resection and were included in this study; 257 received an initially functional anastomosis, 741 a defunctioned anastomosis, and 402 patients a HP. Of the 1400 included patients, 62% were males, 38% were females and the mean age was 67 years (SD 11.1). Following a primary functional anastomosis, 48 (19%) patients received a secondary stoma. Stoma-related complications occurred in six (2%) patients, requiring reintervention in one (0.4%) case. In the defunctioned anastomosis group, stoma-related complications were present in 92 (12%) patients, and required reintervention in 23 (3%) patients, in 10 (1%) of these more than 1 year after initial resection. Stoma-related complications occurred in 92 (23%) patients after a HP, and required reintervention in 39 (10%) patients in 17 (4%) of cases more than 1 year after initial resection. The permanent stoma rate was 11% and 20%, in the functional anastomosis and the defuctioned anastomosis group, respectively. The end colostomy in the HP group was reversed in 4% of cases. CONCLUSIONS: Construction of a stoma after resection for rectal cancer with preservation of the sphincter is accompanied with long-term stoma-related morbidity. Stoma complications are more frequent after a HP. Even after 1 year, a significant number of reinterventions are required.
Published: 2022
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3. Perioperative Opioid Consumption and Clinical Outcomes in Surgical Patients With a Pre-existing Opioid-Based Intrathecal Drug Delivery System

Author: Darrell R. Schroeder, William D. Mauck, Matthew A. Warner, Kalli K. Schaefer, Danette L. Bruns, Brendan Langford, Ryan S D'Souza, Nafisseh S. Warner, and Oludare O Olatoye
Subjects: Adult, Male, Pain medicine, Pacu, Drug Delivery Systems, Interquartile range, Naloxone, Medicine, Humans, Pain Management, Postoperative Period, Perioperative Period, Injections, Spinal, Aged, Retrospective Studies, Pain, Postoperative, biology, business.industry, Chronic pain, Perioperative, Drug Tolerance, Middle Aged, medicine.disease, biology.organism_classification, Confidence interval, Analgesics, Opioid, Anesthesiology and Pain Medicine, Treatment Outcome, Opioid, Anesthesia, Multivariate Analysis, Regression Analysis, Female, Chronic Pain, business, medicine.drug
Abstract: BACKGROUND Intrathecal drug delivery systems (IDDS) have been utilized for over 3 decades for management of chronic pain and spasticity. Patients with IDDS may present for surgical procedures unrelated to the IDDS device, although data are limited regarding perioperative outcomes. METHODS This is a historical matched cohort study conducted between January 1, 2007 and December 31, 2016 of patients with an opioid-based IDDS versus matched control patients undergoing surgery excluding interventional pain procedures. Patients in the IDDS group were matched with up to 2 patients without an IDDS. Multivariable regression analyses were utilized to assess differences in the primary outcome of cumulative perioperative opioid consumption (ie, intraoperative and postanesthesia care unit [PACU] opioid consumption), and opioid consumption during the first 24 and 72 postoperative hours. Postoperative clinical outcomes were also assessed including escalating oxygen requirements, naloxone administration, pain-sedation mismatch, and perioperative pain service consultation. RESULTS A total of 321 surgeries were included, 112 with IDDS and 209 controls, with median (interquartile range [IQR]) age of 57 (49-64) years. Compared to matched controls, patients with an IDDS had greater perioperative opioid consumption (median [IQR] oral morphine milligram equivalents [OME] of 110 [60-163] vs 93 [IQR, 53-142]; adjusted multiplicative increase 1.27 [95% confidence interval {CI}, 1.03-1.57]; P = .029). IDDS patients also had greater opioid consumption in the first 24 and 72 postoperative hours (multiplicative increases of 2.18 [95% CI, 1.35-3.53], P = .002, and 2.39 [95% CI, 1.38-4.15], P = .002, respectively). There were no significant differences in postoperative oxygen requirements, naloxone administration, or pain-sedation mismatch. Inpatient pain medicine consultation was more frequent in IDDS patients compared to controls (51.8% vs 6.2%; P < .001). CONCLUSIONS Patients with opioid-based IDDS received more perioperative opioids and were more likely to receive postoperative pain service consultation compared to matched controls. There were no significant differences in clinical safety outcomes, suggesting tolerance for higher opioid doses. Further research is warranted to optimize perioperative outcomes in those with IDDS.
Published: 2023

4. A Phase i Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation

Author: Kumar Sankhala, Simon Langer, Martijn P. Lolkema, Jennifer R. Diamond, Ingmar Bruns, Isabelle Genvresse, Patricia LoRusso, Martin Gutierrez, Vivek Subbiah, Jaap Verweij, Anthony W. Tolcher, Sant P. Chawla, Prabhu Rajagopalan, Ron H.J. Mathijssen, Florence Atrafi, Joseph Paul Eder, Oliver Boix, and Medical Oncology
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, Paclitaxel, Breast Neoplasms, Mps1 Inhibitor BAY 1217389, Neutropenia, chemistry.chemical_compound, Pharmacokinetics, SDG 3 - Good Health and Well-being, Internal medicine, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Dose escalation, medicine, Humans, Dose-Response Relationship, Drug, business.industry, medicine.disease, Phase i study, chemistry, Toxicity, Female, business, Bay
Abstract: Purpose: Monopolar spindle 1 (MPS1) kinase inhibitor, BAY 1217389 (BAY) synergizes with paclitaxel. This phase I study assessed the combination of BAY with paclitaxel using a novel randomized continuous reassessment method (rCRM) to improve dose determination. Patients and Methods: Patients with solid tumors were randomized to receive oral BAY (twice daily 2-days-on/5-days-off) with weekly paclitaxel (90 mg/m2) or paclitaxel monotherapy in cycle 1. Dose escalation was guided by CRM modeling. Primary objectives were to assess safety, establish the MTD of BAY, and to evaluate the pharmacokinetic profiles for both compounds. Simulations were performed to determine the contribution of the rCRM for dose determination. Results: In total, 75 patients were enrolled. The main dose-limiting toxicities were hematologic toxicities (55.6%). The MTD of BAY was established at 64 mg twice daily with paclitaxel. Inclusion of a control arm enabled the definitive attribution of grade ≥3 neutropenia to higher BAY exposure [AUC0–12 (P< 0.001)]. After determining the MTD, we included 19 patients with breast cancer at this dose for dose expansion. Other common toxicities were nausea (45.3%), fatigue (41.3%), and diarrhea (40.0%). Overall confirmed responses were seen in 31.6% of evaluable patients. Simulations showed that rCRM outperforms traditional designs in determining the true MTD. Conclusions: The combination of BAY with paclitaxel was associated with considerable toxicity without a therapeutic window. However, the use of the rCRM design enabled us to determine the exposure–toxicity relation for BAY. Therefore, we propose that the rCRM could improve dose determination in phase I trials that combine agents with overlapping toxicities.
Published: 2021
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5. Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure

Author: Carlo Alessandria, Carmine Gambino, Javier Fernández, Hans Van Vlierberghe, Sophie Restellini, Marcos Girala, Luis Colombato, Tae Hee Lee, Nikolaos Pyrsopoulos, Eduardo Fassio, Sang Gyune Kim, Gisela Pinero, Paolo Caraceni, Shivaram Prasad Singh, Do Seon Song, Ji Won Park, Julio Vorobioff, Dong Joon Kim, C. Toledo, Aleksander Krag, Liane Rabinowich, Preetam Nath, Robert A. de Man, Elza Cotrim Soares, Xavier Verhelst, Tiago Sevá Pereira, Gustavo Romero, Macarena Simón-Talero, Sung Eun Kim, Michele Bartoletti, Alexander L. Gerbes, Sebastián Marciano, Tony Bruns, Hyoung Su Kim, Ki Tae Suk, Nicolas M. Intagliata, Annette Dam Fialla, Adrià Juanola, Manuela Merli, Rita de Cassia Ribeiro Barea, Laure Elkrief, Rakhi Maiwall, Laurentius A Lesmana, Pere Ginès, Vikas Gautam, E.L. Yoon, M. Marino, Paolo Angeli, Kalyan Ram Bhamidimarri, Victor Vargas, Virendra Singh, Juan Pablo Roblero, François Durand, Cosmas A. Rinaldi Lesmana, M. V. Maevskaya, Gustavo Navarro, Adrian Gadano, Florence Wong, Pramod Kumar, Tae Hun Kim, Daniela Campion, Salvatore Piano, Giacomo Zaccherini, Barbara Lattanz, Jae Seok Hwang, Sun Young Yim, Thomas D. Boyer, Jeong Han Kim, Carlos Brodersen, Wong F., Piano S., Singh V., Bartoletti M., Maiwall R., Alessandria C., Fernandez J., Soares E.C., Kim D.J., Kim S.E., Marino M., Vorobioff J., Barea R.D.C.R., Merli M., Elkrief L., Vargas V., Krag A., Singh S.P., Lesmana L.A., Toledo C., Marciano S., Verhelst X., Intagliata N., Rabinowich L., Colombato L., Kim S.G., Gerbes A., Durand F., Roblero J.P., Bruns T., Yoon E.L., Girala M., Pyrsopoulos N.T., Kim T.H., Yim S.Y., Juanola A., Gadano A., Angeli P., Bhamidimarri K., Boyer T.D., Brodersen C., Campion D., Caraceni P., de Man R.A., Fassio E., Fialla A.D., Gambino C., Gautam V., Gines P., Hwang J.S., Kim H.S., Kim J.H., Kumar P., Lattanz B., Lee T.H., Rinaldi Lesmana C.A., Maevskaya M., Nath P., Navarro G., Park J.-W., Pinero G., Restellini S., Romero G., Seva -Pereira T., Simon-Talero M., Song D.S., Suk K.T., Van Vlierberghe H., and Zaccherini G.
Subjects: Male, 0301 basic medicine, Cirrhosis, Organ Dysfunction Scores, Antibiotic resistance, medicine.medical_treatment, Liver transplantation, Severity of Illness Index, 0302 clinical medicine, ACLF, MDR, Epidemiology, Cross Infection, Mortality rate, Age Factors, Bacterial Infections, Middle Aged, Prognosis, Community-Acquired Infections, Europe, Hospitalization, Female, 030211 gastroenterology & hepatology, Alcohol-Related Disorders, medicine.medical_specialty, Sepsi, India, Risk Assessment, Sepsis, 03 medical and health sciences, Sex Factors, Spontaneous bacterial peritonitis, Internal medicine, medicine, Humans, XDR, Cirrhosi, Hepatology, business.industry, Acute-On-Chronic Liver Failure, medicine.disease, Pneumonia, 030104 developmental biology, antibiotic resistance, liver transplantation, sepsis, business
Abstract: Background & Aims: Bacterial infections can trigger the development of organ failure(s) and acute-on-chronic liver failure (ACLF). Geographic variations in bacteriology and clinical practice could lead to worldwide differences in ACLF epidemiology, phenotypes and associated outcomes. Herein, we aimed to evaluate regional differences in bacterial infection-related ACLF in patients with cirrhosis admitted to hospital. Methods: This post hoc analysis included 1,175 patients with decompensated cirrhosis (with bacterial infection on admission or nosocomial infection) from 6 geographic regions worldwide. Clinical, laboratory and microbiological data were collected from the diagnosis of infection. Patients were followed-up for organ failure(s) and ACLF development according to the EASL-CLIF criteria from enrolment to discharge/death. Results: A total of 333 patients (28%) had ACLF at diagnosis of infection, while 230 patients developed ACLF after diagnosis of infection, resulting in an overall rate of bacterial infection related-ACLF of 48%, with rates differing amongst different geographic regions (38% in Southern Europe vs. 75% in the Indian subcontinent). Bacterial infection related-ACLF more frequently developed in younger patients (55 ± 13 vs. 58 ± 14 years), males (73% vs. 62%), patients with alcohol-related cirrhosis (59% vs. 45%) and those with a higher baseline MELD score (25 ± 11 vs. 16 ± 5) (all p
Published: 2021
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6. Does routine postoperative contrast radiography improve outcomes for patients with perforated peptic ulcer? A multicenter retrospective cohort study

Author: Justin Turcotte, Jason Weinberger, Shreyus S. Kulkarni, Jake Sides, Laura Harmon, Cristina B. Feather, Brandon R. Bruns, Shyam S. Jayaraman, Matthew D. Neal, John R. Klune, Barbara C Eaton, and Anna K. Gergen
Subjects: Male, Leak, medicine.medical_specialty, Colorado, Contrast Media, 030230 surgery, Enteral administration, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Contrast radiography, Humans, Medicine, Mid-Atlantic Region, Digestive System Surgical Procedures, Aged, Retrospective Studies, business.industry, Retrospective cohort study, Mean age, Middle Aged, medicine.disease, Surgery, Radiography, 030220 oncology & carcinogenesis, Peptic ulcer, Peptic Ulcer Perforation, Female, business, Hospital stay, Peritoneal drain
Abstract: Background Perforated peptic ulcer is a morbid emergency general surgery condition. Best practices for postoperative care remain undefined. Surgical dogma preaches practices such as peritoneal drain placement, prolonged nil per os, and routine postoperative enteral contrast imaging despite a lack of evidence. We aimed to evaluate the role of postoperative enteral contrast imaging in postoperative perforated peptic ulcer care. Our primary objective was to assess effects of routine postoperative enteral contrast imaging on early detection of clinically significant leaks. Methods We conducted a multicenter retrospective cohort study of patients who underwent repair of perforated peptic ulcer between July 2016 and June 2018. We compared outcomes between those who underwent routine postoperative enteral contrast imaging and those who did not. Results Our analysis included 95 patients who underwent primary/omental patch repair. The mean age was 60 years, and 54% were male. Thirteen (14%) had a leak. Eighty percent of patients had a drain placed. Nine patients had leaks diagnosed based on bilious drain output without routine postoperative enteral contrast imaging. Use of routine postoperative enteral contrast imaging varied significantly between institutions (30%–87%). Two late leaks after initial normal postoperative enteral contrast imaging were confirmed by imaging after a clinical change triggered the second study. Two patients had contained leaks identified by routine postoperative enteral contrast imaging but remained clinically well. Duration of hospital stay was longer in those who received routine postoperative enteral contrast imaging (12 vs 6 days, median; P = .000). Conclusion Routine postoperative enteral contrast imaging after perforated peptic ulcer repair likely does not improve the detection of clinically significant leaks and is associated with increased duration of hospital stay.
Published: 2021
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7. Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas

Author: Robert S. Meehan, Ashley Bruns, Lamin Jawara, Geraldine O'Sullivan Coyne, James C. Hu, Naoko Takebe, Alice P. Chen, S. Kummar, Andrea Regier Voth, Jared C. Foster, Howard Streicher, Kristen N. Ganjoo, Khanh T. Do, Rene Costello, Elad Sharon, Jennifer Zlott, Larry Rubinstein, Donald P. Bottaro, Warren A. Chow, John Wright, Richard Piekarz, and James H. Doroshow
Subjects: Vascular Endothelial Growth Factor A, Oncology, Cancer Research, medicine.medical_specialty, Cabozantinib, Pyridines, medicine.drug_class, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, Population, Neutropenia, Article, Tyrosine-kinase inhibitor, chemistry.chemical_compound, Rare Diseases, Clinical Research, Internal medicine, Alveolar soft part sarcoma, medicine, Humans, Anilides, Oncology & Carcinogenesis, Progression-free survival, education, Protein Kinase Inhibitors, Cancer, education.field_of_study, business.industry, Evaluation of treatments and therapeutic interventions, Sarcoma, medicine.disease, chemistry, 6.1 Pharmaceuticals, business, Progressive disease
Abstract: Purpose: Soft-tissue sarcomas (STS) are a rare, heterogeneous group of mesenchymal tumors. For decades the mainstay of treatment for advanced, unresectable STS has been palliative chemotherapy. High levels of activated MET receptor have been reported in various sarcoma cell lines, together with elevated vascular endothelial growth factor (VEGF) levels in patients with STS, suggesting that dual targeting of the VEGF and MET pathways with the multi-receptor tyrosine kinase inhibitor cabozantinib would result in clinical benefit in this population. Patients and Methods: We performed an open-label, multi-institution, single-arm phase II trial of single-agent cabozantinib in adult patients with advanced STS and progressive disease after at least 1 standard line of systemic therapy. Patients received 60 mg oral cabozantinib once daily in 28-day cycles, and dual primary endpoints of overall response rate and 6-month progression-free survival (PFS) were assessed. Changes in several circulating biomarkers were assessed as secondary endpoints. Results: Six (11.1%; 95% CI, 4.2%–22.6%) of the 54 evaluable patients enrolled experienced objective responses (all partial responses). Six-month PFS was 49.3% (95% CI, 36.2%–67.3%), with a median time on study of 4 cycles (range, 1–99). The most common grade 3/4 adverse events were hypertension (7.4%) and neutropenia (16.7%). Patients' levels of circulating hepatocyte growth factor (HGF), soluble MET, and VEGF-A generally increased after a cycle of therapy, while soluble VEGFR2 levels decreased, regardless of clinical outcome. Conclusions: Cabozantinib single-agent antitumor activity was observed in patients with selected STS histologic subtypes (alveolar soft-part sarcoma, undifferentiated pleomorphic sarcoma, extraskeletal myxoid chondrosarcoma, and leiomyosarcoma) highlighting the biomolecular diversity of STS.
Published: 2021
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8. Chirurgische und interdisziplinäre Therapie gastrointestinaler Stromatumoren

Author: Markus Ghadimi, Hans F. Fuchs, Thomas C. Schmidt, and Christiane Bruns
Subjects: Oncology, medicine.medical_specialty, Gastrointestinal tract, GiST, business.industry, medicine.medical_treatment, Imatinib, medicine.disease, Primary tumor, digestive system diseases, Internal medicine, medicine, Adjuvant therapy, Surgery, Sarcoma, business, neoplasms, Tyrosine kinase, Neoadjuvant therapy, medicine.drug
Abstract: Gastrointestinal stromal tumors (GISTs) are the most frequent potentially malignant mesenchymal tumors of the gastrointestinal tract. The treatment of GISTs has been revolutionized since imatinib and other tyrosine kinase inhibitors were introduced for the treatment of GISTs, which inhibit the tyrosine kinases c‑KIT and platelet-derived growth factor receptor (PDGFR) alpha. Even after the introduction of this targeted treatment GISTs can only be cured by surgical resection. With interdisciplinary multimodal treatment the prognosis of metastasized GIST can now be further improved by surgical resection of the primary tumor and the metastases, potentially leading to a cure. Neoadjuvant therapy can reduce the extent of surgical resection and hereby enable organ preservation and reduce surgical morbidity. To evaluate molecular and clinical predictors and to offer an optimal therapeutic plan, patients with GISTs and certainly patients with advanced GISTs should be evaluated by interdisciplinary sarcoma boards.
Published: 2021
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9. Chirurgische Therapie des Ösophaguskarzinoms – neue Technologien, moderne Konzepte

Author: Hans F. Fuchs, Christiane Bruns, Benjamin Babic, and Thomas C. Schmidt
Subjects: medicine.medical_specialty, business.industry, General surgery, High volume center, Esophageal surgery, Medicine, Surgery, Esophageal cancer, business, medicine.disease, Surgical treatment
Abstract: In Germany esophageal cancer is mostly treated in specialized centers according to national and international guidelines in a multimodal and interdisciplinary setting. In the next few years centralization of esophageal surgery will continue in Germany due to new national regulations on minimum case volumes. This article highlights new technologies for surgical treatment of esophageal cancer and also depicts the current oncological concepts from the perspective of a high-volume center.
Published: 2021
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10. An Online, Person-Centered, Risk Factor Management Program to Prevent Cognitive Decline: Protocol for A Prospective Behavior-Modification Blinded Endpoint Randomized Controlled Trial

Author: Nawaf Yassi, Stephanie Perin, Amy Brodtmann, Yen Ying Lim, Shantha M W Rajaratnam, Anna Barker, Emily Rosenich, Christopher Barton, Paul Maruff, Darshini Ayton, Leonid Churilov, Matthew P. Pase, Stephanie Pirotta, Ashley I. Bush, Loren Bruns, Renata Morello, Rachel F. Buckley, Alexandra Lavale, and Richard O. Sinnott
Subjects: Male, Gerontology, Motivational interviewing, Telehealth, law.invention, Randomized controlled trial, Behavior Therapy, Risk Factors, law, Intervention (counseling), Humans, Medicine, Dementia, Cognitive Dysfunction, Prospective Studies, Cognitive decline, Aged, Internet, business.industry, General Neuroscience, Cognition, General Medicine, Middle Aged, medicine.disease, Healthy Volunteers, Telemedicine, Cognitive test, Psychiatry and Mental health, Clinical Psychology, Mental Health, Female, Independent Living, Geriatrics and Gerontology, business, Risk Reduction Behavior
Abstract: Background: Several modifiable risk factors for dementia have been identified, although the extent to which their modification leads to improved cognitive outcomes remains unclear. Objective: The primary aim is to test the hypothesis that a behavior modification intervention program targeting personalized risk factors prevents cognitive decline in community-dwelling, middle-aged adults with a family history of dementia. Methods: This is a prospective, risk factor management, blinded endpoint, randomized, controlled trial, where 1510 cognitively normal, community-dwelling adults aged 40–70 years old will be recruited. Participants will be screened for risk factors related to vascular health (including physical inactivity), mental health, sleep, and cognitive/social engagement. The intervention is an online person-centered risk factor management program: BetterBrains. Participants randomized to intervention will receive telehealth-based person-centered goal setting, motivational interviewing, and follow-up support, health care provider communication and community linkage for management of known modifiable risk factors of dementia. Psychoeducational health information will be provided to both control and intervention groups. Results: The primary outcome is favorable cognitive performance at 24-months post-baseline, defined as the absence of decline on one or more of the following cognitive tests: (a) Cogstate Detection, (b) Cogstate One Card Learning, (c) Cogstate One Back, and (d) Cognitive Function Instrument total score. Conclusion: We will test the hypothesis that the BetterBrains intervention program can prevent cognitive decline. By leveraging existing community services and using a risk factor management pathway that tailors the intervention to each participant, we maximize likelihood for engagement, long-term adherence, and for preserving cognitive function in at-risk individuals.
Published: 2021
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11. Latency duration of preterm premature rupture of membranes and neonatal outcome: a retrospective single-center experience

Author: Ann-Christin Stähling, Nora Bruns, Angela Köninger, Hanna Müller, Maria Ai, Christel Weiss, and Ursula Felderhoff-Müser
Subjects: Pregnancy, medicine.medical_specialty, Respiratory distress, business.industry, Obstetrics, Medizin, Gestational age, medicine.disease, Chorioamnionitis, Intraventricular hemorrhage, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Medicine, Gestation, ddc:610, business, Premature rupture of membranes
Abstract: In preterm premature rupture of membranes (PPROM), a decision between early delivery with prematurity complications and pregnancy prolongation bearing the risk of chorioamnionitis has to be made. To define disadvantages of delayed prolongation, latency duration of PPROM in expectantly managed pregnancies was investigated. We included those PPROMs > 48 h leading to preterm birth prior 37 weeks’ gestation and retrospectively analyzed 84 preterm infants fulfilling these criteria. The association between latency duration/appearance of PPROM and respiratory outcome (primary outcomes) and neurological outcome (secondary outcomes) was investigated. The study showed that latency duration of PPROM is not associated with clinical or histological chorioamnionitis (p = 0.275; p = 0.332). As the numerous clinical parameters show multicollinearity between each other, we performed a multiple regression analysis to consider this fact. Respiratory distress syndrome is significantly associated with gestational age at PPROM (p p = 0.014). The other respiratory parameters including steroids and diuretics therapy, bronchopulmonary dysplasia, and the neurological parameters (intraventricular hemorrhage, Bayley II testing at a corrected age of 24 months) were not significantly associated with PPROM duration or gestational age at PPROM diagnosis.Conclusion: Latency duration of PPROM was not associated with adverse neonatal outcome in expectantly and carefully managed pregnancies, but respiratory distress syndrome was pronounced. The observed effect of pronounced respiratory distress syndrome can be treated with surfactant preparations and was not followed by increased rate of bronchopulmonary dysplasia. What is Known:• In case of preterm premature rupture of membranes, a decision between pregnancy prolongation with the risk of chorioamnionitis and early delivery with prematurity complications has to be made.• Chorioamnionitis is a dangerous situation for the pregnant woman and the fetus.• Impaired neurodevelopmental outcome is strongly correlated with pronounced prematurity due to the increased rate of serious complications. What is New:• Respiratory distress syndrome is significantly associated with gestational age at PPROM, and surfactant application is significantly associated with PPROM duration.• Latency duration of PPROM is not associated with adverse respiratory neonatal outcome (therapy with continuous positive airway pressure, therapy with diuretics and/or steroids, bronchopulmonary dysplasia) in expectantly and carefully managed pregnancies.• Intraventricular hemorrhage and Bayley II testing at a corrected age of 24 months are not associated with latency duration of PPROM when pregnancies are carefully observed.
Published: 2021
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12. An Integrative Counseling Approach for African American Couples With Prostate Cancer

Author: Kaitlyn Bruns, Jessica L. Martin, and Andrew W. Wood
Subjects: African american, Prostate cancer, medicine.anatomical_structure, Sexual functioning, Prostate, Developmental and Educational Psychology, medicine, Identity (social science), Cancer, Counseling approach, medicine.disease, Psychology, Clinical psychology
Published: 2021
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13. Short- and long-term follow-up of patients with non-neoplastic esophageal perforation

Author: Wolfgang Schroeder, Hans F. Fuchs, S Brinkmann, Christiane J. Bruns, Arnulf H. Hoelscher, Patrick Sven Plum, Kathrin Kuhr, Jessica M. Leers, Daniel Pinto dos Santos, Laura Knepper, and Seung-Hun Chon
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Perforation (oil well), Stent, Vascular surgery, medicine.disease, humanities, Surgery, Cardiac surgery, Quality of life, Cardiothoracic surgery, medicine, GERD, business, Abdominal surgery
Abstract: Purpose Esophageal perforation is associated with high morbidity and mortality. In addition to surgical treatment, endoscopic endoluminal stent placement and endoscopic vacuum therapy (EVT) are established methods in the management of this emergency condition. Although health-related quality of life (HRQoL) is becoming a major issue in the evaluation of any therapeutic intervention, not much is known about HRQoL, particularly in the long-term follow-up of patients treated for non-neoplastic esophageal perforation with different treatment strategies. The aim of this study was to evaluate patients’ outcome after non-neoplastic esophageal perforation with focus on HRQoL in the long-term follow-up. Methods Patients treated for non-neoplastic esophageal perforation at the University Hospital Cologne from January 2003 to December 2014 were included. Primary outcome and management of esophageal perforation were documented. Long-term quality of life was assessed using the Gastrointestinal Quality of Life Index (GIQLI), the Health-Related Quality of Life Index (HRQL) for patients with gastroesophageal reflux disease (GERD), and the European Organization for Research and Treatment of Cancer (EORTC) questionnaires for general and esophageal specific QoL (QLQ-C30 and QLQ-OES18). Results Fifty-eight patients were included in the study. Based on primary treatment, patients were divided into an endoscopic (n = 27; 46.6%), surgical (n = 20; 34.5%), and a conservative group (n = 11; 19%). Short- and long-term outcome and quality of life were compared. HRQoL was measured after a median follow-up of 49 months. HRQoL was generally reduced in patients with non-neoplastic esophageal perforation. Endoscopically treated patients showed the highest GIQLI overall score and highest EORTC general health status, followed by the conservative and the surgical group. Conclusion HRQoL in patients with non-neoplastic esophageal perforation is reduced even in the long-term follow-up. Temporary stent or EVT is effective and provides a good alternative to surgery, not only in the short-term but also in the long-term follow-up.
Published: 2021
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14. Localized Pigmented Villonodular Synovitis Originating from the Lateral Meniscus in a 17-year-old: Case Report and Literature Review of Meniscal-Associated Localized PVNS

Author: Ruby G. Patel, Jeremy E. Mangion, and Rachel C. Talley-Bruns
Subjects: musculoskeletal diseases, Lateral meniscus, Meniscal tissue, business.industry, Anatomy, Knee Joint, medicine.disease, Tendon sheath, medicine.anatomical_structure, Pigmented villonodular synovitis, Synovial joint, medicine, Orthopedics and Sports Medicine, Surgery, Giant Cell Tumors, business, Mri findings
Abstract: Tenosynovial giant cell tumors (TSGCT) are benign tumors originating from the synovial joint, bursa, or tendon sheath. Localized pigmented villonodular synovitis (PVNS), a subtype of TSGCT, commonly affects the hands and feet and has also been reported in the literature in the knee joint. There is sparse literature on localized PVNS arising specifically from meniscal tissue. We present a case report of a 17-year- old male with symptoms and MRI findings consistent with a lateral meniscus tear. Intraoperatively, the patient was found to have a mass originating from the torn meniscal tissue, which was confirmed by pathology to be a TSGCT. We performed a literature review of intra-articular localized PVNS within the knee presenting as a meniscal tear.
Published: 2021
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15. Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase

Author: George N. Dalekos, Harry L.A. Janssen, Albert Parés, Willem J Lammers, Keith D. Lindor, Frederik Nevens, Jordan J. Feld, Maren H. Harms, Pier Maria Battezzati, Henk R. van Buuren, Marlyn J. Mayo, Pietro Invernizzi, Carla F. Murillo Perez, Christophe Corpechot, Annarosa Floreani, Douglas Thorburn, Tony Bruns, Palak J. Trivedi, Kris V. Kowdley, Xavier Verhelst, Ana Lleo, Aliya Gulamhusein, Cyriel Y. Ponsioen, Nikolaos K. Gatselis, Andrew Mason, Bettina E. Hansen, Gideon M. Hirschfield, Adriaan J. van der Meer, Marco Carbone, Murillo Perez, C, Harms, M, Lindor, K, van Buuren, H, Hirschfield, G, Corpechot, C, van der Meer, A, Feld, J, Gulamhusein, A, Lammers, W, Ponsioen, C, Carbone, M, Mason, A, Mayo, M, Invernizzi, P, Battezzati, P, Floreani, A, Lleo, A, Nevens, F, Kowdley, K, Bruns, T, Dalekos, G, Gatselis, N, Thorburn, D, Trivedi, P, Verhelst, X, Parés, A, Janssen, H, Hansen, B, Gastroenterology and Hepatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Gastroenterology & Hepatology
Subjects: Male, medicine.medical_specialty, Cholagogues and Choleretics, Cirrhosis, Bilirubin, Cholangitis, medicine.medical_treatment, Autoimmune hepatitis, Liver transplantation, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MED/12 - GASTROENTEROLOGIA, Reference Values, Internal medicine, medicine, Humans, Primary Biliary Cholangiti, Survival rate, Hepatology, business.industry, Hazard ratio, Ursodeoxycholic Acid, Middle Aged, medicine.disease, Alkaline Phosphatase, Prognosis, Survival Rate, chemistry, 030220 oncology & carcinogenesis, Cohort, Alkaline phosphatase, 030211 gastroenterology & hepatology, Female, business, Biomarkers
Abstract: INTRODUCTION: In primary biliary cholangitis (PBC), bilirubin and alkaline phosphatase (ALP) are widely established as independent predictors of prognosis. Current treatment goals do not aim for normalization of surrogate markers because their association with survival has not been defined. METHODS: The patient cohort from the GLOBAL PBC Study Group was used, comprising of long-term follow-up data from European and North American centers. Ursodeoxycholic acid-treated and untreated patients with bilirubin levels ≤1 × upper limit of normal (ULN) at baseline or 1 year were included. The association of normal ALP with transplant-free survival was assessed in a subgroup with ALP ≤1.67 × ULN at 1 year. Optimal thresholds of bilirubin and ALP to predict liver transplantation (LT) or death were evaluated. RESULTS: There were 2,281 patients included in the time zero cohort and 2,555 patients in the 1-year cohort. The bilirubin threshold with the highest ability to predict LT or death at 1 year was 0.6 × ULN (hazard ratio 2.12, 95% CI 1.69-2.66, P < 0.001). The 10-year survival rates of patients with bilirubin ≤0.6 × ULN and >0.6 × ULN were 91.3% and 79.2%, respectively (P < 0.001). The risk for LT or death was stable below the bilirubin levels of 0.6 × ULN, yet increased beyond this threshold. Ursodeoxycholic acid-induced reduction in bilirubin below this threshold was associated with an 11% improvement in 10-year survival. Furthermore, ALP normalization was optimal, with 10-year survival rates of 93.2% in patients with ALP ≤ 1 × ULN and 86.1% in those with ALP 1.0-1.67 × ULN. DISCUSSION: Attaining bilirubin levels ≤0.6 × ULN or normal ALP are associated with the lowest risk for LT or death in patients with PBC. This has important implications for treatment targets.
Published: 2020
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16. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Author: Nepogodiev, Dmitri, Simoes, Joana FF, Elizabeth, Li, Picciochi, Maria, Glasbey, James C, Baiocchi, Glauco, Blanco‐colino, Ruth, Chaudhry, Daoud, Alameer, Ehab, El‐boghdadly, Kariem, Wuraola, Funmilola, Ghosh, Dhruva, Gujjuri, Rohan R, Harrison, Ewen M, Lule, Herman, Kaafarani, Haytham, Khosravi, Mohammad, Kronberger, Irmgard, Leventoğlu, Sezai, Mann, Harvinder, Mclean, Kenneth A, Mengesha, Mengistu Gebreyohanes, Modolo, Maria Marta, Ntirenganya, Faustin, Norman, Lisa, Outani, Oumaima, Pius, Riinu, Pockney, Peter, Qureshi, Ahmad Uzair, Roslani, April Camilla, Satoi, Sohei, Shaw, Catherine, Bhangu, Aneel, Omar, Omar M, Ahmed, Waheed‐ul‐rahman, Argus, Leah, Ball, Alasdair, Bywater, Edward P, Brar, Amanpreet, Dawson, Brett E, Duran, Irani, Elhadi, Muhammed, Jones, Conor S, Kamarajah, Sivesh K, Keatley, James M, Lawday, Samuel, Marson, Ella J, Ots, Riinu, Santos, Irène, Taylor, Elliott H, Trout, Isobel M, Varghese, Chris, Venn, Mary L, William, Xu, Dajti, Irida, Gjata, Arben, Kacimi, Salah Eddine Oussama, Boccalatte, Luis, Cox, Daniel, Townend, Philip, Aigner, Felix, Kronberger, Irmgard Elisabeth, Samadov, Elgun, Alderazi, Amer, Hossain, Kamral, Padmore, Greg, Ramshorst, Gabrielle, Lawani, Ismaïl, Cerovac, Anis, Delibegovic, Samir, Gomes, Gustavo Mendonça Ataíde, Buarque, Igor Lima, Gohar, Muhammad, Slavchev, Mihail, Nwegbu, Chukwuemeka, Agarwal, Arnav, Martin, Janet, Ng‐kamstra, Joshua, Olivos, Maricarmen, Lou, Wenhui, Ren, Dong‐lin, Calvache, Jose Andres, Perez Rivera, Carlos J, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Jiménez, Pablo Mijahil Avilés, Gouvas, Nikolaos, Klat, Jaroslav, Novysedlák, René, Amisi, Nicolas, Christensen, Peter, El‐hussuna, Alaa, Batista, Sylvia, Lincango‐naranjo, Eddy, Emile, Sameh, Sandoval, Danilo Alfonso Arévalo, Dhufera, Hailu, Hailu, Samuel, Mengesha, Mengistu G, Kauppila, Joonas H, Arnaud, Alexis P, Demetrashvili, Zaza, Albertsmeier, Markus, Lederhuber, Hans, Löffler, Markus W., Acquah, Daniel Kwesi, Ofori, Bernard, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Aguilera‐arevalo, Maria‐lorena, Recinos, Gustavo, Mersich, Tamás, Wettstein, Dániel, Kembuan, Gabriele, Milan, Peiman Brouki, Khosravi, Mohammad Hossein, Mozafari, Masoud, Hilmi, Ahmed, Mohan, Helen, Zmora, Oded, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Fujimoto, Yuki, Kuroda, Naoto, Abou Chaar, Mohamad K., Ayasra, Faris, Fakhradiyev, Ildar, Hamdun, Intisar Hisham Said, Jin‐young, Jang, Jamal, Mohammad, Karout, Lina, Gulla, Aiste, Rasoaherinomenjanahary, Fanjandrainy, Samison, Luc Hervé, Sánchez, Iran Irani Durán, Gonzalez, Diana Samantha, Martinez, Laura, Martínez, María José, Nayen, Alejandra, Medina, Antonio Ramos‐De, Nunez, Jade, Nashidengo, Pueya Rashid, Shah, Rakesh, Shrestha, Ashish Lal, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, Wright, Deborah, Abdur‐rahman, Lukman, Ademuyiwa, Adesoji, Adisa, Adewale, Osinaike, Babatunde, Seyi‐olajide, Justina, Williams, Omolara, Williams, Emmanuel, Pejkova, Sofija, Al Balushi, Zainab, Sayyed, Raza, Mohsen, Mustafa Abo, Abukhalaf, Sadi A., Cukier, Moises, Gomez‐fernandez, Hugo, Yip, Sebastian Shu, Ojeda, Ximena Paola Vasquez, Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel F., Zarour, Ahmad, Bonci, Eduard‐alexandru, Negoi, Ionut, Efetov, Sergey, Kochetkov, Viktor, Litvin, Andrey, Ingabire, Jc Allen, Bucyibaruta, Georges, Faustin, Ntirenganya, Habumuremyi, Sosthene, Imanishimwe, Alphonsine, Dieu, Haragirimana Jean, Munyaneza, Emmanuel, Ncogoza, Isaie, Ndong, Abdourahmane, Radenkovic, Dejan, Chew, Min Hoe, Koh, Frederick, Ngu, James, Panyko, Arpád, Bele, Uros, Košir, Jurij Aleš, Daoud, Hassan, Bravo, Ana Maria Minaya, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Adam, Mohammed Elmujtba Adam Essa, Rutegård, Martin, Sund, Malin, Adamina, Michel, Gialamas, Eleftherios, Horisberger, Karoline, Alshaar, Muhammad, Huang, Abel, Lohsiriwat, Varut, Charles, Shane, Jlassi, Haithem, Isik, Arda, Lekuya, Hervé Monka, Kopetskyi, Slava, Alsaadi, Hayder, Alshryda, Sattar, Alser, Osaid, Bankhead‐kendall, Brittany, Breen, Kerry, Mashbari, Hassan, Cal, Fernando Bonilla, Al‐naggar, Hamza, Maimbo, Mayaba, Mazingi, Dennis, Abbott, Tom, Akhbari, Melika, Benson, Ruth, Bhanderi, Shivam, Biccard, Bruce, Caruana, Edward, Chakrabortee, Sohini, Chapatwala, Reema, Costas‐chavarri, Ainhoa, Demetriades, Andreas K, Desai, Anant, Di Saverio, Salomone, Drake, Thomas, Edwards, John, Evans, Jonathan, Fiore, Marco, Ford, Samuel, Fotopoulou, Christina, Fowler, Alexander, Futaba, Kaori, Ganly, Ian, James, Harelimana Grace, Griffiths, Ewen, Gronchi, Alessandro, Hutchinson, Peter, Hyman, Gabriella Yael, Incorvia, Joseph, Jain, Ritu, Jenkinson, Michael, Khan, Tabassum, Knight, Stephen Richard, Kolias, Angelos, Kudsk‐iversen, Søren, Kwan, Tsun Yu, Leung, Elaine, Mayol, Julio, Mckay, Siobhan, Meara, John G., Mills, Emily, Moug, Susan, Patel, Akshay, Perinotti, Roberto, Rice, Henry E., Roberts, Keith, Schache, Andrew, Shaw, Richard, Smart, Neil, Stephens, Matthew, Stewart, Grant D., Teasdale, Ella, Vaughan‐shaw, Peter, Vidya, Raghavan, Wright, Naomi, Zimmelman, Natalie, Agastra, Ervis, Thereska, Dariel, Lucchini, Sergio Martin, Laudani, Veronica, Chwat, Carina, Salazar, Ivana Ines Pedraza, Pantoja Pachajoa, Diana Alejandra, Duro, Agustin, Arancibia, José Alfredo Calderón, D’Aulerio, Giuliana, Dudi‐venkata, Nagendra, Egoroff, Natasha, Farik, Shebani, Lott, Natalie, Moss, Jana‐lee, Rennie, Sarah, Tan, Lorwai, Uyen Giao, Vo, Watson, David, Watters, David, Bright, Tim, Hollington, Paul, Zhou, Xuanyu, Kroon, Hidde M, Farfus, Anthony, Barker, John, Watson, Eleanor, Stevens, Sean, Latif, Haider, Dawson, Amanda Caroline, Chuan, Alwin, Muralidharan, Vijayaragavan, Wong, Enoch, Ackermann, Travis, Pacilli, Maurizio, Hodgson, Russell, Heriot, Alexander, Choong, Peter, Brown, Wendy, Lidder, Surjit, Yeung, Justin, Traeger, Luke, Regalo, Guillermo, Gourlay, Ralph, Badiani, Sarit, Koh, Cherry, Putnis, Soni, Haider, Fayza, Mitul, Ashrarur Rahman, Komen, Niels, Dhondt, Bert, Cappeliez, Serge, Pigeolet, Manon, Schoneveld, Martijn, Stijns, Jasper, Oosterlinck, Wouter, Flamey, Nicolas, Kpangon, Cyrille, Agbadebo, Mouhamed, Tobome, Smèvo Romaric, Barros, Aldo Vieira, Júnior, Samuel Aguiar, Amaral Campos, Heloisa Galvão, Gross, Jefferson, Coimbra, Felipe José Fernandez, Kowalski, Luiz Paulo, Makdissi, Fabiana, Nakagawa, Suely, Neto, Joao Pedreira Duprat, Vartanian, Jose Guilherme, Yazbek, Guilherme, Zequi, Stenio C, Flumignan, Ronald, Jaworska, Natalia, Dell, Angela, Shanthanna, Harsha, Behzadi, Abdollah, Nessim, Carolyn, Mozel, Michelle, St‐germain, Pascal, Russell, Crispin, Groot, Gary, Safieddine, Najib, Wijeysundera, Duminda, Eskander, Antoine, Chadi, Sami, Mackenzie, Shawn, Flexman, Alana, Heredia, Fernando, Villanueva, Julio, Waissbluth, Sofia, Macchiavello, Roberto, Escudero, Mario I, Fuentes, Tyare, Mimica, Ximena, Saenz, Dinimo Bolivar, Caicedo, Lina, Alzate, Juan Pablo, Luna, Joaquin, Alonso, Nestor Fabian Pedraza, Silva, Camilo Ortiz, Rodriguez, Juliana, Silva‐igua, Liliana, Torres, Martha Luz, Trujillo, Lina María, Calvache, Albaro José Nieto, Balanta‐melo, Julián, Figueroa‐casanova, Rafael, García‐montoya, Oscar‐julián, Toro, Carlos Andres Marulanda, Botero, Marcela Velez, Arango, Maria Clara Mendoza, Martinez, Eneida Diaz, Perdomo, Valentina Gutiérrez, Montenegro, Emileth, Rodriguez‐abreu, Julia, Mejía, Dolores, Abouelnagah, Galal, Shehata, Sameh, Rida, Ahmed Hossam Eldin Fouad, Hassan, Ramy A., Saad, Mahmoud M., Loaloa, Mohamed Reda, Mostafa, Badr, Qassem, Mohamed, Fahmy, Mohamed, Abozied, Hesham, Azzam, Ahmed Y, Ghozy, Sherief, Sallam, Asser, Shehta, Ahmed, Abdelkhalek, Mohamed, Samaka, Rehab, Morsy, Amr, Sherif, Ahmed Elshawadfy, Negussie, Abraham, Fisseha, Tigist, Shumbash, Kibruyisfaw, Abebe, Metasebia, Yasin, Seid Mohammed, Akililu, Yemisirach Bizuneh, Megersa, Abebe, Tefera, Teshome, Assefa, Melatework, Atnafu, Bahru, Tsegaye, Bereket, Bezabih, Yoseph Solomon, Sisay, Silamlak, Bekele, Kebebe, Jira, Moa, Derilo, Habtamu, Degefa, Eyueal, Tadesse, Anteneh, Nidaw, Melkamu, Sarjanoja, Elise, Testelin, Sylvie, Boucher, Sophie, Jouffret, Lionel, Lakkis, Zaher, Le Bian, Alban Zarzavadjian, Harper, Luke, Déserts, Marc Danguy, André, Benoît, Slim, Karem, Verhaeghe, Romain, Police, Andrea, Girard, Edouard, Chebaro, Alexandre, Nkembi, Armande Subayi, Arnalsteen, Laurent, Ballouhey, Quentin, Mege, Diane, Jeandel, Clement, Duchalais, Emilie, Bouche, Pierre‐alban, Manceau, Gilles, Crétolle, Célia, Hervieux, Erik, Girard, Noémie, Seguin‐givelet, Agathe, Gaujoux, Sebastien, De Simone, Belinda, Boisson, Matthieu, Bergeat, Damien, Fredon, Fabien, Nappi, Francesco, Kassir, Radwan, Scalabre, Aurélien, Migliorelli, Federico, Ezanno, Anne‐cecile, Seeliger, Barbara, Vaysse, Charlotte, Charbonneau, Helene, Misrai, Vincent, Abbo, Olivier, Angeles, Martina Aida, Brunaud, Laurent, Modabber, Ali, Wolf, Sebastian, Kamphues, Carsten, Höhn, Philipp, Glowka, Tim R., Rokohl, Alexander Christopher, Bork, Ulrich, Fluegen, Georg, Horch, Raymund E., Schmedding, Andrea, Schnitzbauer, Andreas, Eberbach, Helge, Schlager, Daniel, Spelsberg, Fritz, Keppler, Lena, Hecker, Andreas, Wolfer, Susanne, Ronellenfitsch, Ulrich, Nitschke, Christine, Peiper, Christian, Hakami, Ibrahim, Welter, Stefan, Nikolaieva, Karine, Roth, Andreas, Lindert, Judith, Gousias, Konstantinos, Rissmann, Anke, Linz, Valerie Catherine, Rahbari, Nuh, Rassweiler‐seyfried, Marie‐claire, Gut, Anna Eleonora, Gempt, Jens, Reim, Daniel, Wagner, Arthur, Keppler, Alexander M., Stoleriu, Mircea Gabriel, Saier, Tim, Stadler, Josef, Kaiser, Julia Christina, Brunner, Stefan M., Pfister, Karin, Herzberg, Jonas, Nowak, Kai, Reinhard, Tobias, Stavrou, Gregor A., Königsrainer, Alfred, Konrads, Christian, Quante, Markus, Laban, Simon, Pusch, Silke, Hirschburger, Markus, Doerner, Johannes, Wiegering, Armin, Tampaki, Ekaterini Christina, Ruiz, Alitza Gutiérrez, Rodas, Alejandra, Portilla, Ana Lucía, Carrera, Jacqueline, Duarte, Amalia Barrios, Lowey, Megan, Barillas, Sabrina, Suroy, Atul, Vaishnav, Dhaivat, Chowdappa, Raghunandan Gorantlu, Madabhavi, Irappa, Bhat, Dhananjaya, Venkatappa, Sunil Kumar, Thakar, Sumit, Jain, Kavitha, Kumar, Aruna, Nagar, Manoj, Mishra, Tushar, Sekar, Arunkumar, Gupta, Anand, Kaman, Lileswar, Karthigeyan, Madhivanan, Tripathi, Manjul, Rammohan, Ashwin, Vayoth, Sudheer Othiyil, Rajanbabu, Anupama, Subbian, Anbukkani, Gupta, Rahul, Raut, Monish, Evelyn, Nissi, Kannaiyan, R Lavanya, Matai, Anil, Misra, Sanjeev, Bhende, Vishal, Muthu, Sathish, Ghosh, Indranil, Sharma, Abhishek, Bajaj, Ankur, Rajan, Shiv, Agarwal, Gaurav, Pawar, Pranay, Alexander, Philip, Vijayakumar, M Vijayakumar, Hameed, Zeeshan, Badareesh, L, Chaudhry, Navneet Kumar, Baliarsing, Lipika, Dharap, Satish, Kulkarni, Amruta, Thyavihally, Yuvaraja, Sharma, Rahul Deo, Pramesh, C S, Soni, Rajesh, Dube, Surya Kumar, Sharma, Shilpa, Singh, Harvinder, Bains, Lovenish, Ghodke, Rahul, Kumar, Ashwani, Sodhai, Vivek, Maji, Suvendu, Basu, Somprakas, Mahakalkar, Chandrashekhar, Kannan, Ravi, Mehraj, Asif, Ranganath, N, Phadnis, Ashish, Yadev, I, Kavalakat, Alfie, Mittal, Rohin, Vallam, Karthik Chandra, Akhavizadegan, Hamed, Maleki, Esmaeil Rezghi, Kandevani, Naser Yousefzadeh, Ikele, Hilary, Mcnestry, Catherine, Fleming, Christina, O’Brien, Stephen, Elwahab, Sami Abd, Davis, Niall, Javadpour, Mohsen, Mcdonnell, Brendan, Connor, Clare O, Bolger, Jarlath, Clancy, Cillian, Croghan, Stefanie M, Donlon, Noel, Cullinane, Carolyn, Creavin, Ben, Muheilan, Muheilan, Earley, Helen, Kabir, Syed Mohammad Umar, Fahadullah, Muhammad, Ryan, Éanna, Connelly, Tara, Hashimoto, Daisuke, Alqudah, Majdi Ali, Alajalen, Amer, Omari, Rand Y., Qasem, Abdulrahman, Alawneh, Yazan, Ahmad, Amer, Aladawi, Omar, Alrayes, Bourhan, Haidar, Hanan, Husain, Shatha, Qassem, Faisal, Sumadi, Adnan, Salhiyeh, Ala’a Abu, Al‐manaseer, Balqees Mahmoud, Alsunna, Zaid, Ra’Ed, Hazim, Hamad, Faten Reyad Bani, Abuleil, Amro, Jimaale, Elmi Ahmed Mohamed, Abu‐mehsen, Marah, Olaywah, Noor, Wafi, Omar, Ababneh, Hazim, Abu‐ismail, Luai, Khamees, Almu’Atasim, Alkhatib, Ahmad, Bolatbekova, Raikhan, Kulimbet, Mukhtar, Nurgozhin, Talgat, Saliev, Timur, Zhussupov, Baurzhan, Almabayev, Ydyrys, Kaidarova, Dilyara, Tamoos, Khalil, Aqeelah, Ahmed, Mohammed, Alsnosy Abdullah Khalefa, Al Maadany, Faraj, Alkadeeki, Ghadah, Gahwagi, Milad, Aldressi, Wafa, Amnaina, Mohamed, Alansari, Arowa Hassan Abdulrahman, Alkaseek, Akram, Yagoub, Ghozlan, Amer, Anass Ben, Salem, Marwa, Almugaddami, Ayman, Burgan, Dania, Abdelkabir, Mohammed, Alshareef, Khayriyah, Islam Ben Jouira, Rayet, Meelad, Ayman, Bouhuwaish, Ahmad, Dwaga, Sumayya Essayah, Khalifa, Houda, Almiqlash, Bushray, Suliaman, Taha, Alawami, Mohammed, Elhajdawe, Fras, Aboazamazem, Hajir, Ellojli, Ibrahim, Msherghi, Ahmed, Saleh, Ismail Ali, Alayan, Mohammed, Ndayishyigikiye, Marcel Didier, Munyika, Akutu, Plarre, Philipp, Borowski, David W, Wells, Cameron, Teague, Rebecca, Elliott, Brodie, Kieser, David, Mohyieldin, Omar, Mcintosh, Nick, Haran, Cheyaanthan, King, Jasmin, Jeong, Ha, Mcguinness, Matthew James, Adesanya, Opeoluwa, Olaogun, Julius, Akinmade, Akinola, Bwala, Kefas, Agbonrofo, Peter, Afolabi, Akinwale, Usang, Usang, Ekenze, Sebastian, Olori, Samson, Lawal, Taiwo Akeem, Okunlola, Abiodun, Kache, Stephen, Sale, Danjuma, Anyanwu, Lofty‐john, Okereke, Chukwuma, Tolani, Musliu Adetola, Filipce, Venko, Todorovic, Lazar, Stavridis, Sotir, Massoud, John George, Alsibai, Sareyah, Sultan, Rizwan, Altaf, Humera Naz, Bhatti, Abu Bakar Hafeez, Waqar, Shahzad Hussain, Aziz, Aliya, Kerawala, Asad Ali, Rai, Lajpat, Anwer, Mariyah, Tariq, Aiman, Ayub, Bushra, Niazi, Sami Ullah, Naseem, Muhammad Yasir, Sarwar, Muhammad Zeeshan, Khokhar, Muhammad Imran, Zahid, Imdad Ahmad, Majid, Haroon Javaid, Talat, Nabila, Asif, Muhammad, Chaudhary, Muhammad Hamid, Farooq, Umer, Ahmad, Siddique, Mabood, Waleed, Bukhari, Syed Imran, Tariq, Muhammad, Yaqoob, Eesha, Javed, Saad, Malik, Muhammad Usman, Yaqoob, Hassan Nawaz, Pacheco, Glenda Marina Falcon, Melendez, Robinson Mas, Urbina, Arazzelly Del Pilar Paucar, Chiuyari, Jose Rios, Alvarado, Carlos Eduardo Otiniano, Lau, Lorena Fuentes Rivera, Borda‐luque, Giuliano, Niquen‐jimenez, Milagros, Arias, Claudia, Zegarra, Sergio, Pallardel, Jenner Betalleluz, Oscco, Regina Amparo Ugarte, Mendiola, Gian, Colmenares, Yahaira Tatiana Carpio, Zapata, Carlos Shiraishi, Ortiz, Maria Rosa, Borges, Filipe Castro, Viveiros, Octavio, Serralheiro, Pedro, Santos‐costa, Paulo, Mendes, Filipa, Melo, Miguel Rocha, Cardoso, Paulo, Soares, Ana, Pereira, Rita Gonçalves, Silva, Nelson, Caiado, André, Sacras, Maria Luís, Azevedo, Pedro, Almeida‐reis, Rui, Oliveira, João, Nogueiro, Jorge, Sampaio‐alves, Mafalda, Costa, Luciana Cidade, Baía, Catarina, Deus, Ana Cláudia, Branquinho, Rita, Marçal, André, Tojal, André, Makkai‐popa, Silviu Tiberiu, Mironescu, Aurel, Grama, Florin, Toma, Elena Adelina, Filipescu, Daniela, Bacalbasa, Nicolae, Motas, Natalia, Ionescu, Sebastian, Ginghina, Octav, Costea, Radu, Zarnescu, Narcis Octavian, Drasovean, Radu, Dimofte, Mihail‐gabriel, Porumb, Vlad, Kirov, Mikhail, Molitvin, Yegor, Pykhteev, Vadim, Raevskaya, Marianna, Butyrskii, Aleksandr, Alshahrani, Mushabab, Althumairi, Azah, Alzerwi, Nasser, Al Ameer, Ahmed, Madkhali, Tariq, Almulhim, Abddulrahman Saleh, Ghazwani, Salman, Ayoub, Abdu, Iskander, Othman, Ghunaim, Mohammed, Alharthi, Mohammed, Alzaidi, Turki M, Alyami, Mohammad, Al Amri, Abdulrahman, Alfakhri, Abdullah, Alhefdhi, Amal, Chowdhury, Sharfuddin, Nouh, Thamer, Alshehri, Ameen, Alzahrani, Abdulrahman, Alalawi, Yousef, Awad, Selmy, Konate, Ibrahima, Tendeng, Jacques, Teo, Nan Zun, Aqil, Sabra, López, Cristina Barrena, Mozo, Ana Sánchez, Infante, Antonio Rodriguez, Vivancos, Patricia Caja, Prieto, Mikel, Roman, Igor Alberdi San, Fernandez, Laura Gomez, Vives, Josep Maria Muñoz, Carreras‐castañer, Anna, Díaz‐feijoo, Berta, Sieira‐gil, Ramon, Turrado‐rodriguez, Victor, López, Anna Sánchez, Sánchez‐cabús, Santiago, Toscano, Marta Jimenez, Sin, MªPilar Canals, Laura, Saura García, Sole, Oriol Martin, Bellver, Pedro Palazon, Pérez‐bertólez, Sonia, Prat‐ortells, Jordi, Martínez, Mireia Riba, Rubio‐palau, Josep, Tarrado, Xavier, Nuñez, Jorge, Mendoza, Veronica Alonso, Bescós, Coro, Espin‐basany, Eloy, Espinosa‐bravo, Martin, Gil‐sala, Daniel, González‐suárez, Susana, Estruch, Nuria Montferrer, Mariño, Lucia Porteiro, Rodríguez‐tesouro, Ana, Portilla, Fabian Rojas, Pérez, M Pilar Tormos, Vives, Inmaculada, De Cortazar, Unai Garcia, Tudela, Kiara, Landaluce‐olavarria, Aitor, Gómez, Mercedes Estaire, Almoguera, Jorge, Ugarte‐sierra, Bakarne, Jimenez, Virginia, Bertrand, Marta, Puiggrós, Laura Cárdenas, Delisau‐puig, Olga, Garcia‐adamez, Jorge, Bergkvist, David Julià, Maldonado‐marcos, Eloy, García, Lucia Diego, Golet, Marta Roldón, Soto‐darias, Iván, Rahy‐martín, Aida Cristina, Enjuto, Diego, Ramos‐luengo, Adolfo, Fernandez, Juan Delgado, Duarte, Carolina Lugo, Thies, Cristina Ojeda, Marquez, Lucila, Vita, Diana Crego, Dziakova, Jana, Velasco, Jorge Caño, Mateo‐sierra, Olga, Quintana‐villamandos, Begoña, Valcarcel, Cristina Rey, Rio, Javier, León, Laura Román García, Di Martino, Marcello, Prada, Jorge, González, Javier Serrano, Losada, Manuel, Gomez, Jose Tomas Castell, Corripio‐sanchez, Ramon, Forero‐torres, Alexander, Morales‐puebla, José Manuel, Perez‐chrzanowska, Hanna, Gonzalez, Santiago Valderrabano, Yebes, Alvaro, Zapardiel, Ignacio, Alonso, Manuel Diez, Palacios, Nelson Morales, Sánchez, Alberto Cabañero, Fernández, Fátima Sánchez, Gurumeta, Alfredo Abad, Abad‐motos, Ane, Corella, Fernando, Ripollés‐melchor, Javier, Sanz‐gonzalez, Rosa, Fuentes, Marta Alcaraz, Martín, Maria Teresa Fernández, Espino, Pablo Calvo, Prats, Milagros Carrasco, Fernández‐lópez, Antonio‐josé, Escudero, Damián García, Soria, Vanesa Garcia, Alonso, Jesús Aarón Martínez, Ruiz‐marín, Miguel, Pérez, Beatriz Gómez, Moya‐angeler, Joaquin, Martínez, Daniel Fernández, Bayo, Heura Llaquet, Colás‐ruiz, Enrique, Romera, Susana Bella, Pellicé, M. Teresa Gavaldà, Solé, Misericòrdia Jordà, Velasquez, Enrique Jose Ruiz, Núñez, Bernardo, Jimenez, Raul, Zabaleta, Jon, González‐gimeno, Maria Jose, Vázquez, Irene Ortega, Ferrer, Antonio Perez, Martín‐láez, Rubén, Suarez, Marcelo Moreno, Eiras, Miguel Angel Freiria, Ramallo‐solís, Irene, Gomez‐rosado, Juan‐carlos, Guillen, Jose Ramon Oliver, Boira, Mar Achalandabaso, Bauset, Juan Carlos Catalá, Domenech, Julio, Badenes, Rafael, Bernal‐sprekelsen, Juan Carlos, Sancho‐muriel, Jorge, De Andrés‐Asenjo, Beatriz, Tejero‐pintor, Francisco J, Vallve‐bernal, Marc, Melero, Alba Vazquez, Blasco, Laura Sánchez, Escartin, Jorge, Mallén, Victoria Duque, Srishankar, Selvaratnam, Sooriyabandara, Charitha, Basnayake, Oshan, Gunawansa, Nalaka, Weeraddana, Prabuth Dulanjan, Vimalakanthan, Thanusan, Gishanthan, Shanthamoorthy, Chandrasinghe, Pramodh, Sauvain, Marc‐olivier, Ghazal, Ahmad, Al‐sabbagh, Yusra, Alhassoun, Turki, Albared, Sara Maa, Naem, Antoine, Alnahr, Hareth, Jisry, Ghassan, Hammed, Ali, Xaviour, Okedi Francis, Turinawe, Gaston, Mubezi, Isaac, Sikakulya, Franck K., Kakeeto, Andrew, Kabweru, Wilberforce M., Kiweewa, Ronald, Matovu, Paul, Isaac, Otolia, Mashhour, Mohamed, El Helw, Amin, Kherani, Safeena, Mohamed, Awadelkarim, Abbas, Ferial Mohamed Ali, Mohammed, Diary, Aldlyami, Ehab, Kundra, Rakesh, Michael, Antony Louis Rex, Khalil, Kareem S., Dbeis, Rachel, Shaikh, Shafaque, Ferry, Jenny, Jamal, Aiman, Siddique, Haleema, Das, Rishi, Ponugoti, Nikhil, Rattanasirivilai, Pornjittra, Sultana, Asma, Mosley, Frances, Chan, Matthew, Bateman, Antony, Davies‐jones, Gareth, Georgiades, Fanourios, Ahmadi, Navid, Coonar, Aman, Baig, Mariam, Khatri, Chetan, Surendran, Arthika, Sonksen, Julian, Sinnerton, Robert, Brennan, Caitlin, Faulkner, Gemma, Greenhalgh, Michael, Emerson, Hannah, Singisetti, Kiran, Totty, Joshua, Wilson, Michael, Terence, Lo, Corbett, Harriet, Okonkwo, Ijeoma, Arbane, Gill, Kerawala, Cyrus, Parmar, Chetan, Bath, Michael, Odejinmi, Funlayo, Sagar, Jayesh, Talwar, Rishi, Newman, Samuel, Hammond, John, Moir, John, Duric, Natalie, Szakmany, Tamas, Talib, Ahmar Iftikhar, Youssef, Mina, Lewis‐lloyd, Christopher, Lami, Mariam, Ayub, Khurram, Dean, Benjamin, Balasubramanya, Supriya, Lakpriya, Sathya, Rogers, Luke, Turner, Paul, Maher, Mark, Sigamoney, Kohila, El Kafsi, Jihène, Hardie, John, Johnson, David, Henein, Christin, Hollyman, Marianne, Agarwal, Ketan, Powell, Simon, Chauhan, Govind Singh, Patel, Rakesh, Gagnier, Joel, Carmichael, Heather, Aurora, Null, Olson, Kristofor A., Etchill, Eric, Hirji, Sameer, Naunheim, Matthew, Drake, Frederick, Reinke, Caroline, Alecci, Anna, Vaysburg, Dennis, Rodriquez, Jennifer, Shih, Emily, Ban, Vin Shen, Coleman, Julia, Kaups‐fresno, Krista, Giorgakis, Emmanouil, Dinome, Maggie, Bhutiani, Neal, Alnachoukati, Omar, Aiken, Taylor, Diehl, Thomas, Gosain, Ankush, Rattan, Rishi, Ghani, Muhammad Owais Abdul, Ruzgar, Nensi Melissa, Liveris, Anna, Glass, Nina, Paranjape, Charu, Chin, Theresa, Meola, Antonio, Nicholson, Kristina, Squiers, John, Lueckel, Stephanie, Reisenauer, Janani, Callcut, Rachael, Mansour, Ahmed, Berndtson, Allison, Kornblith, Lucy, Seegert, Sara, Martins, Paulo, Al‐shehari, Mohammed, Al‐raimi, Ibrahim, Ngulube, Allan, Siamuchembu, Maphios, Mushiwokufa, Willard, Mlambo, Busisiwe, Chinyowa, Simbarashe, Bollano, Enton, Gjyli, Kostandin, Kerpaci, Jola, Vrapi, Enxhi, Zijaj, Lorena, Djahida, Bahraoui, Zohra, Belabbes Fatima, Khadidja, Kouidri, Bali, Oussama, Benallel, Nassim, Lalmi, Ismahene, Abdoun, Meriem, Aouabed, Nesrine, Bouaoud, Souad, Bouchenak, Kamel, Haif, Assia, Soualili, Zineddine, Bastet, Joaquin, Bianco, Agustín, Capitaine, Daniel, Lozada, Jorge Centeno, Esquivel, Carlos, Figueroa, Rodrigo, Garcia, Manuel, García, Pablo Martín, Gerchunoff, José Ignacio, Iascano, Fernando Martinez, Mondino, Jose, Muriel, María Emilia, Pablo, Carmignani, Passadore, Martin, Tornini, Alejandra, Traverso, Rogelio, Vargas, Lara, Zanoni, Gerardo, Berber, Norberto, Cotta, Estefanía, Di Vincenzo, Marcela, Gallino, Esteban Sebastian, Gigena, Cecilia, Grassano, Bianca, Lugones, Ignacio, Madrid, Constanza, Maricic, Maximiliano, Martinez, Antonio Alberto, Rosso, Andres, Scher, Pablo, Tachella, Sofia, Zezular, Damaris Idara Anabel, Abuawad, Carla, Forneris, Agustin Albani, Allemand, Carola, Calzaretta, Laura Gisela Alvarez, Boretto, Jorge G., Boudou, Rocio, Brandariz, Rodrigo, Buljubasich, Martin, Burchakchi, Arturo, Buttaro, Martin, Campana, Juan Pablo, Busnelli, Virginia Cano, Carminatti, Tomas, Lalín, Agustina Florencia Castro, Cereghini, Julian, Amor, María Sol Crespi, Croattini, Roberto Sebastián, Fernandez, Maria Sol, Figari, Marcelo, Fraidenraij, Uriel, Gallegos, Diego, García‐mansilla, Agustín Maria, Gonzalez, Marcos, Gonzalez, Matias Ignacio, Salazar, Esteban Gonzalez, Goransky, Jeremias, Gauna, Guillermo Hernandez, Higuera, Felipe, Holc, Fernando, Jauregui, Esteban Gabriel, Larrañaga, Juan, Liyo, Juan, Llano, Lionel, Lobos, Pablo, Luzzi, Emilia, Mastroianni, Gustavo, Mata‐suarez, Santiago Miguel, Mayer, Horacio F., Loughlin, Santiago Mc, Mendoza, Efrain, Mentz, Ricardo Esteban, Mercado, Pedro, Moyano, Pablo, Noll, Florencia, Odetto, Diego, Oliva, Agustina Rene, Vidal, Rafael Perez, Poggi, Catalina, Premoli, Eduardo Jorge, Ramos, María Lourdes, Rosas, Patricio, Rossi, Luciano, Rossi, Gustavo, Saadi, Jose, Scherñuk, Jordán, Slullitel, Pablo, Stang, María Verona, Taboada, María Victoria, Tirapegui, Sebastian, Uffelmann, Constanza, Vaccaro, Carlos, Vagni, Roberto, Valerio, Ana Clara, Zarratea, Celeste Soledad, Montal, Silvina, Morris, Brian, Valdez, Pedro, Diaz‐couselo, Fernando, Sabatini, Luciana, Alvarez, Fernando Andres, Avila, Micaela, Benitez, Nicole Benitez, Bruera, Nicolás, Doniquian, Marcelo, Gielis, Manuel, Liaño, Julian, Llahi, Florencia, Mandojana, Facundo, Páez, Walter, Parodi, Matias, Molina, Héctor Picon, Pinsak, Agustin, Viscido, German, Badra, Roberto, Belisle, Diego, Borla, Hernan, Eberle, Georgina, Esteban, Agustin, Ferrero, Carlos Ignacio, Furlan, Micaela, García, José Sebastian, Granero, Lucas, Henzenn, Mariel, Juaneda, Rodrigo, Vidal, Esteban Politi, Reyna, Guillermo Romero, Montero, José Gabriel Yaryura, Caubet, Maria Mercedes, D’Addino, José Luis, Daryanani, Deepu, Gosselink, Martijn, Ponson, Alex, Afzal, Mohamed, Amprayil, Mathew, Brooke‐smith, Mark, Chen, John, Grantham, James, Gricks, Benjamin, Hii, Amanda, Kundu, Nikhil, Liu, David, Livingston, Charles, Marshall‐webb, Matthew, Mcveay, Christina, Moore, Hamish, Nair, Gavin, Ong, Bee Shan, Parker, Dominic, Rudolph‐stringer, Victoria, Szpytma, Malgorzata, Vissapragada, Ravi, Wee, Melissa Yun, Wong, Geoffrey Yuet Mun, Barnett, Dylan Richard, Bochner, Melissa, Bolt, John, Buddingh, Karel, Coventry, Brendon, Davis, Sean, Dawson, Joseph, Denham, Stuart, Dobbins, Christopher, Fitridge, Robert, Gan, Siang Wei, Haque, Izhar‐ul, Herath, Matheesha, Jog, Shivangi, Kanhere, Harsh, Kuang, Beatrice, Lam, Yick Ho, Lambert, Virginia, Lim, Alicia, Maina, Grace, Moller, Cea‐cea, Neo, Eu Nice, Neo, Eu Ling, Nguyen, Alain, Prasad, Shalvin, Roy, Jennifer, Russell, Christine, Sammour, Tarik, Smith, Nicholas, Smith, Richard, Stranz, Conrad, Tourani, Saam, Tran, Steven, Van de Ven, Lucinda, Warren, Leigh, Whitfield, Robert, Wormald, Jamie, Yin, Yijie, Bierton, Christopher, Cribb, Benjamin, Foley, Katarina, Ong, Daniel, Watson, Matthew, Hampton, Jacob, Karam, James, Rugendyke, Anya, Zhang, Tyson, Vasey, Carolyn, Apellaniz, Eduardo, Frankel, Adam, Gahan, Lara, Guerra, Glen R, Liesegang, Amanda, Lutton, Nicholas, Maurice, Andrew, Miron, Scott, Prasad, Aveechal, Sercombe, Ashleigh, Sivapalan, Thanusan, Ahmad, Syed Danial Syed, Tee, Chin Li, Yaksich, Lachlan, Batstone, Martin, Breik, Omar, Young, Thomas, Field, Michael, Scott, Benjamin, Charlton, Gabriella, Chen, Si, Cheung, Henry Yan Chi, Gauri, Neha, Hayhurst, Ross, James, Sophie, Jang, Seyoung, Jia, Fangzhi, Zhang, Helen, Aujla, Randeep, Finsterwald, Michael, Percy, Digby, Tanaya, Alvin, Trivedi, Anand, Aylett, Andrew, Grills, Richard, Holmes, Angela, Kwok, Matthew Ming Kei, Lambers, Anton, Lambers, Leo, Lok, Evania, Nagra, Sonal, Page, Richard, Paltoglou, Nicholas, Panuganti, Vishwakar, Riddell, Sophie, Rudock, Gareth, Tan, Hannah, Underwood, Kirk, Youssef, Daniel, Amoils, Ricci, Bahtigur, Nazli, Bengeri, Savitha, Builth‐snoad, Lily, Cheah, Hock Ping, Chen, Paul, Chew, Kenneth, Chong, Alyssa, Clark, Sara, Kaul, Rhea Darbari, Devan, Eliya, Ewington, Christina, Fatima, Aleeza, Fitt, Sophia, Gaul, John, Ghosal, Paloma, Gojnich, Amy, Gunawardena, Indu, Hamer, Peter, Holmes, Samuel, Hou, Zhen, Jolly, Danielle, Kane, James Dimitri, Kaufman, Micayla, Khandelwal, Tanishq, Khanijaun, Sukhwant, Kwok, Kelvin, Latif, Edward, Laura, Sharon, Lee, Vivian, Leung, Catherine, Liang, Ina, Lin, Peter, Lun, Elizabeth Weng Yan, Luo, Haili, Victor, Ly, Jolande, Ma, Macnab, Brooke, Mcgee, Richard, Miles, Stephanie, Munro, William, Narroway, Harry, Ngan, Tin Yau, Noor, Anthony, Pahalawatta, Upuli, Park, Melissa, Parkin, Cameron, Poon, Rita, Somasundaram, Shanmugam S, Saab, Claudia, Simpson, Renwick, Steinel, Dana, Taylor, Emily, Tchen, Adrian, Thong, Shu, Tran, Kelvin, Tree, Kevin, Vance, Lucille, Wong, Ken, Victor, Yu, Zhang, Michael, Cox, Aram, Tan, David Chi Hau, Thani, Nova, Das, Shefali, Macdonald, Taigh, Salama, Paul, Sandhu, Gagandeep, Shadbolt, Rachel, Phan, Du, Townend, David, Eunmaro, Ju, Lee, Sang Mi, Barnett, Stephen, Kheslat, Hajar Hasan, Higgins, Andrew, Jamieson‐grigg, Chloe, Jenkins, Victoria, Larner, Brett, Perini, Marcos, Proud, David, Qin, Kirby, Riddiough, Georgina, Seevanayagam, Sivendran, Damien M., Wu, Zhao, Chris, Aggarwal, Sonali, Vinna, An, Battershell, Melanie, Chan, Elliot, Cheung, King Tung, Drake, Anna, Goonawardena, Janindu, Hunt, Benjamin, Christopher, Ip, Iyer, Vikram, Jain, Anshini, Kealey, Joshua, Lew, Chen, Lim, Christopher Seng Hong, Luck, Tara, Mackay, Sean, Maher, Natalie, Maroske, Georgia, Roubos, Nicholas, Sengupta, Shomik, Steen, Christopher, Tsigaras, Zac, Tuttle, Zachary, Ward, Salena, Williams, Marli, Yeap, Evie, Zhou, Jessie, Coates, Amy, Mutalima, Nora, Tran, Ton, Nataraja, Ramesh, Sharpin, Claire, Bird, David, Choy, Kay Tai, Condron, Sarah, Daruwalla, Jurstine, Anjos, Isabela, El‐khoury, Hanna, Fabian, Robert, Gillard, Andrew, Greenop, Rebecca, Issa, Michael, Lee, Sharon, Mori, Krinal, Petrakis, Nikki, Qureshi, Maryum, Sabella, Danielle, Satasivam, Prassannah, Sathianathen, Niranjan, Seow, Sean Ezekiel, Shen, Amanda, Shi, Margaret, Tabassum, Meher, Teixeira, Rodrigo, Vivian‐taylor, Josephine, Wheatley, Jennifer, Shepherd, Sally, Soucisse, Mikael, King, Sebastian, O’Connor, Brendan, Teague, Warwick, Banting, Simon, Chong, Lynn, Clatworthy, Sharnel, Cochrane, Angela, Fox, Adrian, Hii, Michael Wei, Isaacs, Anna, Johnson, Mary Ann, Knowles, Brett, Newcomb, Andrew, Price, Veronique, Raman, Jaishankar, Read, Matthew, Rowcroft, Alistair, Taylor, Lillian, Wright, Gavin, Chana, Prem, Shaw, Kalai, Bock, Jacob, Cory, Jordan, Drummond, Katharine, Lahy, Jack, Mcintire, Thomas, Price, Benjamin, Stark, Claire, Besson, Alex, Gartrell, Richard, Lauritz, Brianne, Nguyen, Ha My Ngoc, Ong, Chui Foong, Pitcher, Meron, Scullion, Lorna, Tang, Howard, Taylor, Danielle, Wolf, Brigid, Wichmann, Matthias, Davis, Amelia, Maurel, Amelie, Raubenheimer, Kyle, Campbell, Cassidy, Colaco, Ashley, Machado, Maria Julia Corbetta, Heffernan, Abbie, Karihaloo, Costa, Ludbrook, Isabella, Park, Sean SW, Peerally, Bibi Nabeeha, Singhai, Camila, Stevens, Heidi, Vavilov, Sergey, Aubin, Anne‐marie, Harris, Margaret, Lim, Zhi Ying, Spring, Rebecca, Stieler, Melissa, Barnes, Nicholas Adamson, Alam, Ahmad Seraj, Alsoudani, Ali, Amico, Francesco, Anning, Rebecca, Balogh, Zsolt J., Blatt, Alison, Cairns, Scott, Carroll, Jesse, Caterson, Andrew, Christie, Adam, Cope, Daron, Dale, Tyson, Dennis, Grace, Duggal, Anchal, Ennis, Brendan, Fenton, Mark, Yi Xin Joanna, Fu, Galevska‐dimitrovska, Ana, Gani, Jonathan, Gelzinnis, Scott, Gramlick, Madelyn, Hadlow, Claudia, Hardstaff, Ruth, Heer, Munish, Holmes, Merran, Hone, Bridget, Sophie, Hu, Huang, Linna, Iqbal, Ramiz, Jefferson, Niall, Kasthurirathne, Dimithi, Kuo, Stephen, Lau, Wayne Yan, Liang, Hsin‐ping, Lim, Daniel, Lin, Rosalina, Mcdonogh, Jack, Mcilwain, Elysse, Ming, Yan Joyce, O’Neill, Christine, Ocsan, Ryan James, Oosthuizen, Benjamin, Organ, Nicole, Otieno, James, Park, Felicity, Paterson, Amanda, Cerdeira, Marisol Perez, Peters, Luke, Petersson, Josefin, Rubbo, Sonia, Siribaddana, Venesa, Thurairajah, Kabilan, Ting, Caleb, Watson, Antonia, Way, Teagan, Wiadji, Elvina, Willoughby, Ellisha, Bailey, Ashley, Broadbent, Samuel, Narayanan, Viswanathan, Stephens, Samuel, Wilkes, Anna, Zhao, Jie, Ballal, Mohammed, D’Souza, Carl, Forbes, Clara, Goss, Matthew, Haddleton, Monique, Harty, Jacinda, Hayne, Dickon, Hew, Nicole, Koh, Wee Ling, Lee, Shawn, Malik, Shahbaz S, Abdul, Naseer Mohammed, Richards, Toby, Seow, Yi Th Ng, Wong, James, Archer, Leigh, Azaman, Nur Sabrina Binti Babe, Dilevska, Tina, Foo, Jonathan, Hans, Tasvinder, Jansen, Shirley, Kumar, Mohit, Leeson, Christopher, Pham, Terence, Pineda, Fernando Picazo, Rajakumar, Saravanan, Suk‐udom, Supisara, Tan, Jonathan, Thurston, Benjamin, Zhao, Bichen, Gupta, Shivangi, Hou, Lachlan, Jeyamanoharan, Nivedan, Leigh, James, Poh, Wei Shearn, Sala, Michael, Crothers, Rebecca, Dravid, Madhulika, Harrison, Ben, Islam, Sumayya, Mccartney, Conor, Nel, Henco, Pearson, Natasha, Apostolou, Christos, Berney, Christophe, Chou, Richard, Hanna, Sam, Lam, Andrew, Vanessa, Ma, Phanse, Salonee Shubhen, Elliott, Michael, Phung, Daniel, Barry, Jessica, Clark‐mackay, Eleanore, Cope, Jennifer, Halliwell, Richard, Chen, Ji, De Robles, Marie Shella, Llorando, Alyssa, Mahin, Humaira Haider, Rao, Dominic, Syed, Faisal, Abulafia, Daniel, Buckland, Benjamin, Cordingley, Timothy, Debiasio, Ashe, Drane, Andrew, Ireland, Patrick, Julien, Benji, Lan‐hoa, Le, Lee, Austin Yeon Suk, Loh, Eu Jhin, Middleton, Andrew, Mortimer, Brienna, Sebastian, Samuel, Short, Brooke, Stewart, Peter, Ruyven, Stephanie, Wong, Daniel, Zhang, Charry, Zhu, Bonnie, Ziaziaris, William, Leitner, Aran, Tolzman, Lukas, Zitt, Matthias, Rakos, Gergely, Székely, György, Djedovic, Gabriel, Königsrainer, Ingmar, Allmer, Caterina, Herritsch, Barbara, Mitteregger, Martin, Schauer, Christian, Seitinger, Gerald, Siebenhofer, Carmen, Uranitsch, Stefan, Duller, David, Mathew, Erwin, Skias, Christoph, Andrianakis, Alexandros, Belarmino, Armin, Brinskelle, Petra, Castellani, Christoph, Cohnert, Tina, Fediuk, Melanie, Fink, Andrea, Holzmeister, Clemens, Kahn, Judith, Kresic, Josip, Leithner, Andreas, Lindenmann, Joerg, Lumenta, David, Michelitsch, Birgit, Mikalauskas, Saulius, Nischwitz, Sebastian P., Puchwein, Paul, Roj, Andrej, Schemmer, Peter, Singer, Georg, Smolle‐juettner, Freyja‐maria, Till, Holger, Wolf, Axel, Andraschofsky, Tibor Oliver, Angerer, Rafael, Arco, Daniel, Kaufmann, Claudia, Kilic, Nura, Widschwendter, Peter, Angermann, Reinhard, Bauer, Marlies, Bergmann, Nicole, Freyschlag, Christian, Gisinger, Martin, Gollmann‐tepeköylü, Can, Graber, Michael, Haim, Alexander, Harasser, Carina, Härter, Bettina, Hirsch, Jakob, Hofer, Markus, Holfeld, Johannes, Huber, Anna Lena, Kralinger, Martina, Krappinger, Dietmar, Kuen, Marlene, Liebensteiner, Michael, Messner, Franka, Messner, Alex, Naegele, Felix, Ninkovic, Marijana, Nowosielski, Yvonne, Osl, Antonia, Ower, Cornelia, Pölzl, Leo, Rauchegger, Teresa, Reimer, Daniel, Riecke, Johannes, Schwabegger, Anton H., Sokolovski, Filipp, Strimmer, Anna, Süss, Markus, Thaler, Martin, Umlauft, Julian, Zehetner, Claus, Zeimet, Alain G., Allerstorfer, Jakob, Haslhofer, David, Hofer, Daniel, Luger, Matthias, Pisecky, Lorenz, Poier, Nikolaus, Rubicz, Nina, Schmolmüller, Christoph, Zwittag, Paul, Rossmann, Tobias, Ruiz‐navarro, Francisco, Stefanits, Harald, Elsayed, Hend, Habertheuer, Peter, Hajkova, Tereza, Loidl, Wolfgang, Luger, Ferdinand, Windischbauer, Amadeus, Fischer, Ines, Függer, Reinhold, Kirchweger, Patrick, Saini, Thomas, Berger, Julian, Fraz, Wolfgang, Nia, Arastoo, Kenez, Mihaly, Nichita, Margit, Magele, Astrid, Mayr, Thomas, Noe, Chiara, Bittner, Reinhard, Borhanian, Kurosch, Dornauer, Isabella, Emmanuel, Klaus, Gabersek, Ana, Gantschnigg, Antonia, Grechenig, Michael, Gruber, Ricarda, Hutter, Jörg, Jäger, Tarkan, Koch, Oliver, Lechner, Michael, Manzenreiter, Lisa, Mayer, Franz, Muehlbacher, Iris, Presl, Jaroslav, Rezaie, Daniel, Schredl, Philipp, Varga, Martin, Weitzendorfer, Michael, Wimmer, Angela, Brunner, Eberhard, Cillia, Michael, Gruber, Michaela, Grünbart, Martin, Heinrich, Elmar, Hoi, Hannes, Kemmetinger, Vanessa, Mittermair, Christof, Mosshammer, Victoria, Obrist, Christian, Paal, Peter, Roesch, Judith, Russe, Elisabeth, Schaetz, Tobias, Schirnhofer, Jan, Schwaiger, Karl, Wechselberger, Gottfried, Weiss, Helmut, Lanner, Maximilian, Binder, Alf‐dorian, Gürtler, Thomas, Fink, Marcus, Reichhold, Daniel, Stoyanova, Radoslava, Beitl, Klara, Bernardi, Martin H., Datler, Philip, Dawoud, Christopher, Farr, Alex, Foessleitner, Philipp, Grimm, Christoph, Harpain, Felix, Hoda, Mir Alireza, Holawe, Simone, Kranawetter, Marlene, Ott, Johannes, Perricos, Alexandra, Pesta, Maximilian, Pillerstorff, Robert, Reiterer, Christian, Riss, Stefan, Rosta, Klara, Scheriau, Georg, Tschernko, Edda, Wenzl, Rene, Wiedemann, Dominik, Wohlrab, Peter, Zapletal, Bernhard, Zimmermann, Matthias, Zimpfer, Daniel, Findl, Oliver, Fisus, Andreea, Ruiss, Manuel, Komaz, Melanie, Meindl, Nikolaus, Primavesi, Florian, Stadlbauer, Karl Heinz, Stättner, Stefan, Steiner, Florian, Cerny, Ondrej, Falkensammer, Eva, Knotzer, Hans, Köglberger, Paul, Poidinger, Bernhard, Wiesinger, Clemens Georg, Burtscher, Johannes, Rath, Sebastian, Trivik‐barrientos, Felipe, Aliyeva, Gunay, Behbudov, Vuqar, Muslumov, Gurbankhan, Zeynalov, Natiq, Alam, Mahmood, Alfayez, Fatema, Hasan, Batool, Mahdi, Maryam, Mulla, Husain, Qader, Kawthar, Saeed, Amr, Shirazi, Ahmed, Albastaki, Aysha, Birido, Nuha, Chagla, Hiba Hameed, Dawaishan, Abdulla, Dawaishan, Baheya, Farhan, Abeer, Juma, Isam, Khan, Asher, Patel, Aqsa Mohammad Eqbal, Srinivasan, Madhu, Deen, Fatema Waheed Akbar Mohamad Akbar Nawab, Abdulqadir, Seemal, Jabr, Abdulla, Maqsood, Fauzia, Almoosa, Noora, Naseer, Mai, Alam, Mohammed Shadrul, Basher, AKM Khairul, Islam, Shahnoor, Islam, S. M. Nazmul, Karim, Sabbir, Faisel, Muntasir, Khan, Sadia, Mannan, Iftekhar Ibne, Nazia, Nawshin, Bentham, Malissa, Corbin, Sasha, Doyle, Alex, Eastmond, Asha, Haynes, Amelia, O’Shea, Margaret, Phillips, Emil, Walkes, Keisha, Artyushkov, Evgeniy L., Kaplan, Mark L., Straltsov, Vladislav, Litvina, Yauheniya, Lyzikov, Alexei, Tihmanovich, Victor E., Borges, Mafalda, Brits, Tim, De Hous, Nicolas, De Wachter, Stefan, Menovsky, Tomas, Mortiers, Xavier, Vermeulen, Dorien, Vleminckx, Nils, Ysebaert, Dirk, Bontinck, Julie, Bulthé, Danny, Rasschaert, Ricky, Van Haver, Anne‐sophie, Van Belle, Koen, Verstraeten, Laurence, Vounckx, Manon, D’Ulisse, Sébastien, De Bruyne, Yasmine, El Nakadi, Badih, Heloise, Tessely, Luisetto, Matteo, Marinakis, Sotirios, Maton, Maxime, Viste, Claire, Van Daele, Elke, Vandeputte, Mathieu, Duinslaeger, Marc, Jacobs‐tulleneers‐thevissen, Daniel, Jansen, Yanina, Janssens, Ward, Kunda, Rastislav, Messaoudi, Nouredin, Ruyssers, Michael, Van Eetvelde, Ellen, Vanhoeij, Marian, Van den Eynde, Jef, Van den Eynde, Raf, Chaoui, Ahmed M., Akpla, Marcellin, Lawani, Souliath, Agossou, Hermann, Behanzin, Hulrich Aouagbe, Bokossa, Covalic, Dewanon, Hubert, Yome, Hugues, Boukari, Alassan, Gbehade, Oswald, Tobome, Sèmèvo Romaric, Amossou, Labissi Francois, Dossou, Francis, Barišić, Tatjana, Boras, Miran, Brekalo, Zdrinko, Blagojević, Ivana Čuljak, Damjanović, Ana, Dragisic, Vedran, Šimić, Ana Dugandžić, Gunaric, Filip, Kajic, Martin, Knežević, Darko, Krešić, Tanja, Lasić, Valentina, Letica, Ludvig, Martinovic, Vlatka, Mikulic, Iva, Miskovic, Josip, Pehar, Hrvoje, Rastović, Pejana, Sesar, Irena, Šetka‐čuljak, Violeta, Soljic, Martina, Tiric, Dejan, Tomić, Vajdana, Vasilj, Anja, Hudic, Igor, Oliver, Renato Aguera, Lamonica, Felipe Azenha, De Medeiros, Jorge, Florindo, Henrique Donizetti Bianchi, Filho, Rodolfo Jose Favaretto, Pereira, Fernanda Costa, Rodrigues, Rodrigo, Junior, Antonio Antunes Rodrigues, Andrade, Fernanda Ruiz, Salvetti, Maisa, Campioto, Débora Schalge, Lamonica, Mayra Tuboi, Urbano, Gustavo, Prado, Ricardo Villela, Alonso, Nivaldo, Santos, Carlos Ferreira, Tonello, Cristiano, Pires, Robinson Esteves, Rezende, Ricardo Fernandes, Reis, Igor, Marson, Fernando Augusto Lima, Ferreira, Erick Pires, Palamim, Camila Vantini Capasso, Brandao, Marcelo, Souza, Tiago Henrique, Maunsell, Rebecca, Neto, Alfeu Accorsi, Accorsi, Guilherme, Fernandes, Murilo Francisco, Machareth, Camila, Moura, Barbara Viegas, Dias, Vanessa, Guarienti, Luciano, Sampaio, Lia Regina, Vendrame, Cristiano, Coelho, Tatiane Amorim, Becker, Karin, Dias, Andre, Fachin, Camila Girardi, Gomes‐da‐silva, Monica Maria, Moraes, Isabela, Pinto, Amanda, Stychnicki, Adriano Seikiti, Julio, Nathalia Siqueira, Santos, José Mauro, Junior, Humberto Fenner Lyra, Oliveira, João Carlos Costa, Onzi, Tiago Rafael, Gerber, Marlus Tavares, Coelho, Filipe Osni, Silva, Janaína Carla, Panis, Carolina, Rech, Daniel, Avelino, Melissa, Botacin, Lais, Gonçalves, Mateus Capuzzo, Santos Leite, Amanda Lira, Pol‐fachin, Laercio, Bezerra, Tainá Santos, Santos Junior Alcimar, Alcimar Lavareda, Amorim, Robson, Leão, Maria Eduarda Bellotti, Bergamasco, João José Corrêa, Pinheiro, Cintia Cardoso, Neto, Rubem Alves Da Silva, De Araújo, Elaine Francisca, Guimaraes, Lilian, Liborio‐kimura, Tatiana, Camara, Isabelle Melo, Siqueira, Victor Ripardo, Rodriguez, Juan, Silva, Jeancarllo, Junior, Rubem Alves Silva, Cardoso, Cláudio, Guimaraes, Andre, Alves, Wislene Sarajane Moreira, Menezes, Agna Soares Da Silva, Araujo, Marcelo, Brito, Kattiucy, Albuquerque, Josie Marcelle Lira, Dussan‐sarria, Jairo Alberto, Souza, Andressa, Stüker, Andre Ricardo, Bresciani, Tiago, Stefani, Luciana Cadore, Cavazzola, Leandro Totti, Costa, Tainá, Dasqueve, Matheus, Marangon, Gustavo De Bacco, Martins, Otávio Ritter Silveira, Rodrigues, Josy, Cardoso, Guilherme Roloff, Neto, Brasil Silva, Soares, Tilaê, Zanella, Aline, Filippi, Lucas Torelly, Guerra, Enilde Eloena, Cruz, Ricardo Pedrini, Kalil, Antonio Nocchi, Laporte, Gustavo, Salem, Moacyr, Lima Brazan, Murilo, Campos Prado, Caio Antonio, Moises, Elaine Christine Dantas, Suto, Hilda Satie, Yasuda, Alice Gadotti, Zani, Ana Carolina Tagliatti, Santos, Roberto Cardoso Cardoso, Duarte, Geraldo, Joviliano, Edwaldo Edner, Santos, Carolina Lourenço Gomes, Quintana, Silvana Maria, Tamashiro, Edwin, Valera, Fabiana Cardoso Pereira, Zaccaro, Marília Veccechi Bijos, Andreotti, Isis, Lima, Leonardo, Salgado, Wilson, Cunha Viana Júnior, Alonço, Moutinho, Lana, Oliveira, Cora Pichler, Martins, Isabela Trindade, Toledo, Isabela Vieira, Guimaraes‐filho, Marco Antonio Correa, Arrivabeno, Rodrigo, Murta, Claudio Bovolenta, Said, Danniel Frade, Junior, Jose Pontes, Pugliesi, Felipe Guimarães, Gregorio, Paulo, Mariani, Alessandro, Minamoto, Fabio, Silva, Juliana Lourenço, Muller, Bruno, Zanon, Caio, Carvalho, Vladimir C., Lima, Ana Lucia Munhoz, Oliveira, Priscila R, Santos Silva, Jorge, Teixeira, Mariana Faccini, Kulcsar, Marco, Matos, Leandro, Nunes, Kamilla Schmitz, Junior, Joel Abdala, Abdallah, Emne, Carvalho, Genival Barbosa, Farias, Igor Correia, Silva, Cassia, Eloi Pinto, Fabio Fernando, Facure, Luciana, Godoy, André, Kupper, Bruna, Leite, Fernanda, Melo Lôbo, Matheus, Mantoan, Henrique, Marques, Narimã, Marques, Tomas, Medici, João Paulo, Torres, Silvio Melo, Garcia, Katheryne Merlos, Meduna, Rafael Ribeiro, Herbst, Ana Carolina Scintini, Santos, Silvana Soares Dos, Gonçalves, Bruna Tirapelli, Antonini, Marcelo, Brienze, Carolina, Farah, José Francisco, Gonçalves, Rodrigo, Machado, Vinicius, Nadal, Luis Roberto, Rodrigues, Danilo Nadal, Pansani, Adrieli, Rocha, Maria Luiza, Simonsen, Marcelo, Tsuchiya, Daniela, Vasques, Rafaela, Amorim, Jorge, Carvalho, Ana Alyra, Correia, Rebeca, Santos, Brena Costa, Neto, Henrique Jorge Guedes, Nakano, Luis, Pereda, Mariana, Vasconcelos, Vladimir, Awada, Jamile Barakat, Gava, Guilherme, Ijichi, Tiago Riuji, Kim, Nam Jin, Nunes, Rafael, Pinto, Fabio, Pereira, Thiago Henrique Sigoli, Volpe, Gustavo Jardim, Gatti, Arthur, Nardi, Caroline, Oliva, Ramon, Oliveira, Layze Braz, Carvalho, Herica Emilia Félix, Ribeiro, Ivonizete Pires, Rodrigues, Gabriel Renan Soares, Sousa, álvaro Francisco Lopes, Chebel, Michel, Sousa Fernandes, Paulo Henrique, Freitas, Marcelo Augusto Faria, Cunha, Juliano Rodrigues, Ather, Zeenia, Dimitrov, Dobromir, Filipov, Emil, Gyokova, Elitsa, Ilieva, Ivelina, Ivanov, Tsvetomir, Karamanliev, Martin, Neykov, Vasil, Atanasov, Boyko, Belev, Nikolay, Kamenova, Paolina, Tonev, Kaloyan, Yotsov, Tsanko, Hristova, Evguenia, Spassov, Kolyo, Tsankov, Tsanko, Dardanov, Dragomir, Gribnev, Petar, Sokolov, Manol, Brown, James, Tanyi, John, Hurdle, Heather, Maclean, Anthony, Sander, Michael, Al Riyami, Salim, Bali, Krittika, Bigam, David, Dajani, Khaled, Anvari, Mehran, Bolis, Rafik, Choi, David, Ellis, Susan, Gupta, Michael, Hanna, Wael, Hong, Dennis, Horner, Cynthia, Luketic, Lea, Moisiuk, Peter, Shargall, Yaron, Alfaro, Hilda, Alkhamesi, Nawar, Allen, Laura, Brackstone, Muriel, Chan, Eunice, Cheng, Davy, Chui, Jason, Gonzalez, Nelson, Lanting, Brent, Macneil, S. Danielle, Mayer, Robert, Mcgee, Jacob, Nagappa, Mahesh, Power, Nicholas, Prempeh, Agya, Qiabi, Mehdi, Razvi, Hassan, Schemitsch, Emil, Sehmbi, Herman, Shah, Ushma, Subramani, Yamini, Vasarhelyi, Edward, Vogt, Kelly, Yang, Homer, Abdehgah, Ali Ghorbani, Balvardi, Saba, Feldman, Liane, Fiore, Julio Flavio, Hanson, Melissa, Hopkins, Brent, Kaneva, Pepa, Lee, Lawrence, Leonard, Julia, Abou‐khalil, Jad, Martel, Andre, Stevenson, James, Lee, Susan, Merchant, Richard, Avoine, Samuel, Belanger, Laurence, Belanger, Mathieu, Belzile, Etienne, Blais, Anne‐sophie, Boucher‐kovalik, Sofia, Boulanger‐gobeil, Cindy, Cardinal, Etienne, Champagne, Pierre‐olivier, Cloutier, Jonathan, Corriveau‐durand, Simon, Cote, Mathieu, Cote, Maxime, Côté, Mathilde, Courval, Valérie, Demers, Suzanne, Desbiens, Christine, El Ouazzani, Mehdi, Girard, Karine, Girard, Ève‐marie, Gosselin, Karo, Khuong, Helene, Labrecque, Nathalie, Langlais, Eve‐lyne, Larouche, Audrey, Lavallée, Andréane, Lemyre, Madeleine, Maheux‐lacroix, Sarah, Marien, Melissa, Marin, Patrick, Mauger, Julie, Milot, Genevieve, Nadeau, Sylvie, Nguyen, Sebastien, Paris, Mélinda, Pelet, Stéphane, Plante, Marie, Plante, Carole, Pouliot, Frederic, Renaud, Marie Claude, Sarlabous, Mathilde, Schmit, Isabelle, St‐germain, Raphaël, Johnston, Brian, Labine, Nicole, Persad, Amit, Pham, Hong, Wood, Melissa, Azam, Riordan, Atrey, Amit, Beckett, Andrew, Cohen, Daniel, Das, Sunit, Daza, Julian, Dunkerton, Cheryl, Ellenbogen, Yosef, Hanley, Ciara, Kellett, Sorcha, Khoshbin, Amir, Ladha, Karim, Mcfarlan, Amanda, Montgomery, Spencer, Pazmino‐canizares, Janneth, Suresh, Hrishikesh, Vasdev, Ravleen, Ahmed, Maira, Gentili, Fred, Kalyvas, Aristotelis, Millesi, Matthias, Sarica, Can, Shaikh, Taariq, Leslie, St, Jacques, Null, Tabasinejad, Raha, Zadeh, Gelareh, Hsiao, Marvin, Jedrzejko, Nicole, Black, Peter, Broe, Claire, Dandurand, Charlotte, Grey, Rebecca, Leung, Philemon, Lindberg, Andrew, Gutierrez, Juan Mata, Mayson, Kelly, Meneghetti, Adam, Phillips, Drew, Street, John, Calderón, Carolina Carvajal, Pizarro, Daniel Alejandro Donoso, Fernández, Esteban, Molero, Ángela, Mutarello, Nastassja, Lucic, Jorge Núñez, Gaete, Katherine Ochoa, Lopez, Catalina Ruiz, Sepúlveda, Rina, Ulloa, Camila, Barreda, Mauricio, Dallaserra, Matias, Wood, Matías Günther, Tobar, Mauricio Sandoval, Garcia‐huidobro, Francisco, Dona, Jimena, Diez, Carolina Soto, Igor, Daniel, Mena, Javier, Reyes, José Tomás, Soto, Catalina Arredondo, Campos, Jose, Gonzalez, Javier, Rivera, Barbara, Altamirano‐villarroel, Jaime, Cohn, David, Amesti, Luis Marin, Recabal, Pedro, Sandoval, Camilo, Fonseca, Bruno Catoia, Contador, Monica, Hodali, Andres, Pincheira, Camila, Mantilla, Andrea Ramos, Garrido, Claudio Salas, Torres, Janina, Valenzuela, Marco, Chen, Zehua, Jiankun, Hu, Tao, Jin, Yang, Kun, Zhang, Yuexin, Chen, Yuan, Cunchuan, Wang, Yang, Wah, Bai, Xueli, Liang, Tingbo, Tao, Ma, Ning, Pu, Yin, Hanlin, Caicedo, Camilo, Beltran, Diego Felipe Tellez, Escobar, Alejandro, Granados, Carolina Perez, Pinzon, Lisbeth Alexandra Urueña, Bonilla, Carlos, Santana, Diana, Serrano, Oscar, Garcia, Andrea, Luque, Fernando Giron, Patino‐jaramillo, Nasly G., Baquero, Laura Giselle Contreras, Botero, Nestor Augusto Muñoz, Castellanos, Jhoana Andrea Murillo, Calvera, Andrea Juliana Vega, Acosta Buitrago, Lina M., Bohórquez‐tarazona, Maria Paz, Rivera, Paulo Andrés Cabrera, Felipe Casas, J, Alfaro, Valeria Cormane, Corso, Julian, Guerra, Bayron, Guerrero‐becerra, Albert Franz, Abiyomaa, Akram Kadamani, Montes, Felix Ramon, Paz, Manuel Santiago Mosquera, Sandoval, Camilo Andrés Polanía, Quintana, Natalia, Ortega, Carlos Fernando Roman, Santacruz, Carlos, Téllez, Manuela, Sánchez, Camilo Alejandro Velandia, Arias‐amézquita, Fernando, Vargas, Luis Felipe Cabrera, Murgueitio, Natalia Cortes, Escorcia, Elkin, Ghotme, Kemel Ahmed Ghotme, Gomez‐mayorga, Jorge Luis, Vergel, Alvaro Felipe Guerrero, Herrera‐almario, Gabriel, Londono‐schimmer, Eduardo, Mejia, Juan A., Monsalve, Guillermo, Rodriguez, Camilo, Niño, Juan Nicolas Rodriguez, Ortegón, Luis Martín Rodríguez, Sanabria, Daniel, Alvarez, Andres, Andrade, Arnulfo, Ardila‐montealegre, Javier, Baquero, David, Vidales, Edgar Mauricio Barrios, Giraldo, María Alejandra Caicedo, Carvajal, María Camila, Castillo, Maria, Florez, Maria Carolina Castillo, Cendales, María Angelica, Monroy, Danny Conde, Cortes, Henry, Daniel, Mario, De la Peña, Jairo, Delgado‐nieto, Elena Leonor, Espitia, Hernando, Avendaño, Carlos Figueroa, Burgos, Edgar Oswaldo Hernandez, Isaza‐restrepo, Andres, Londono, German, Maldonado, Margarita Maria, Montenegro, Andrea, Navarro, Juan Carlos, Navarro‐alean, Jorge, Abaunza, Katherine Parra, Pulido, Eliana, Ramírez Amaya, Erika M., Chaves, Carlos Eduardo Rey, Rincón, Natalia Andrea Rivera, Castillo, William Mauricio Riveros, Sanchez, Lizeth Rodriguez, Rubiano, Wilson, Russi, Maria, Olarte, Juan Carlos Sabogal, Tovar, Javier Mauricio Salgado, Sanchez, Maria Juliana, Varela, David Mauricio Solano, Gomez, Paula Torres, Trillos, Marcial, Patiño, Ana María Vargas, Vargas‐barato, Felipe, Leon, Juan Pablo Villate, Useche, María Alejandra Wagner, Acosta, Jesus, Almeciga, Adriana, Mendez, Luis Becerra, Beltran, Rafael Jose, Bonilla, Ana, Buitrago, Miguel, Cabrera, Marino, Quiroz, Pedro Hernando Calderon, Camacho‐nieto, Diego, Fierro, Carlos Andrés Carvajal, Bonilla, Sergio Cervera, Diaz, Sandra, Facundo, Helena, Forero, Jorge, Mora, Mauricio Garcia, Tirado, Karena Victoria Garcia, Perez, German Fabian Godoy, Gonzalez, Felipe, Guevara, Oscar, Hernandez, Jairo Alonso, Mora, David Ricardo Herrera, Lalinde, Juan David, Lehmann, Carlos, Llanos, Eduardo Leon, Lopez, Byron Eduardo Lopez De Mesa, Mariño, Ivan, Medina, Monica, Morales, Raúl Eduardo Pinilla, Puerto, Angela, Null, Ma, Quintero‐ortíz, Andrea, Hernández, Juliana Rendón, Cortés, Elio Fabio Sánchez, Hernández, Alvaro Eduardo Sánchez, Suarez, Raul, Suescun, Oscar, Vanegas, Marco, Varela, Rodolfo, Bernal, Jorge Luis Velez, Viveros‐carreño, David, Gómez, Daniela Camargo, Fletcher, Angelica, Merchan, Abel, Luna, Euler Javier Burbano, Cujiño, Indira, Galvis, Mauricio Velasquez, Galliadi, Lina Maria Vergara, Gonzalez, Orlando Abonia Gonzalez Abonia, Saravia, Maria Fernanda Acuna, Arroyave, Roberto, Angulo, Jose Maria Barreto, Bonilla‐escobar, Francisco Javier, Cardona, Uriel, Giacometto, Ivan Castañeda, Castillo, José Luis, Castillo‐cobaleda, Diego Fernando, Garcia, Diego Jose Caycedo, Tello, Brenda Marcela Coll, Dueñas‐ramirez, Juan Carlos, Vidarte, Oscar Andres Escobar, Figueroa, Luis, Garcia‐perdomo, Herney, Gomez, Alden, Gomez, Laura, Gomez, Alejandro, Grande‐gil, Ana María, Guarin, David, Guzman, Natalia, Castañeda, Enrique Herrera, Hinaoui, Marisol, Escobar, Anuar Armando Idrobo, Kammerer, Christian Kammerer, Leon, Sergio, Lucero, Carlos Antonio Llanos, López, Angie, Martinez‐blanco, Alexander Maximiliano, Casella, Antonio José Montoya, Corredor, Ricardo Andres Niño, Ordoñez, Sebastian, Uribe, Diego Alfredo Palta, Serna, Andrea Carolina Perea, Ríos, July, Ríos‐samper, Gabriel, Garcia, Juan David Rivera, Moreno, Juan Camilo Salcedo, Sandoval, John, Ramirez, Guillermo Alberto Sarmiento, Romero, Paola Andrea Tabares, Urzola, Ricardo, Valdes‐duque, Iliana Maria, Velasquez, Miguel, Villegas, Lina Maria, Zapata‐copete, James, Lara, José Omar Zorrilla, Zuluaga, Mauricio Zuluaga, Moreno, Alejandra Echeverri, Figueroa, Juan Sebastian, Ortiz, Adolfo Enrique Gómez, Mosos, Maria Fernanda Gonzalez, González‐orozco, Alejandro, Roncancio, Juan Jose Jaramillo, Martínez, María Camila Leyva, Mosos, Monica, Ramirez, Juan Sebastian, Rodríguez, Henry Andrés, Henao, Juan David Saavedra, Varón, María Alejandra Torrado, Ramírez, Leidy Natalia Idarraga, Ocampo, Lorena, Marin, Monica Cardona, Gonzalez, Ana Maria Marin, Mejia, David Alejandro, Vanegas, Luis Emiro, Martinez, Yicel Alvarez, Vesga, Sandra Aruachan, Fuentes, Dayana Vanessa Baron, Salas, Alejandra Caballero, Estrada, Gustavo Antonio Martinez, Campo, Kelly Viloria, Alvarez, Juan Antonio Corralez, Regino, Cesar David Galindo, Velasquez, Angela Maria Giraldo, Moreno, Carlos Enrique Melo, Tejada, Jorman H., Tovar, Jesus Hernan, Tovar, German Alirio, Hernández, Edison Alexander Benavides, Orozco‐chamorro, Claudia Milena, Angel, Gustavo Adolfo, Buesaquillo, Christian Ali, Montaño, Victor David Olave, Sánchez‐gómez, Andrés, Ureche, Daniela Patricia Escalante, Garrido, Jairo Martinez, Genda, Eben‐ezer, Eboma, Fabrice, Bitunjac, Kristina, Grulović, Karlo, Vučković, Marijana, Šantak, Goran, Borovic, Emanuel, Versic, Ana Bosak, Hasandić, Damir, Grabar, Natasa Poldan, Medancic, Suzana Srsen, Brkic, Lucija, Cokarić, Sara, Palac, Petra Pavic, Samac, Zeljka, Tomić, Josipa, Vrdoljak, Marija, Bacic, Ivan, Bakmaz, Bernarda, Vučičić, Nikolina Bratošević, Brzic, Domagoj, Canovic, Samir, Dijan, Emilio, Dragicevic, Maja Grgec, Karlo, Robert, Konjevoda, Suzana, Kovačević, Petra, Kovačić, Ivan, Markulić, Frane, Matak, Luka, Morović, Domagoj, Perišić, Gordan, Simic, Andrea, Skitarelić, Neven, Veršić, Matea, Žufić, Vanja, Zuzul, Matea, Anzic, Srdan Ante, Carevic, Iva, Litvic, Dubravka Heli, Markov‐glavas, Duska, Jovanovic, Tatjana Savic, Augustin, Goran, Biloš, Jerko, Biočina, Bojan, Biosic, Vedrana, Bobovec, Dino, Botica, Iva, Bumber, Boris, Čerina, Petra, Vukovic, Katarina Duric, Gasparovic, Hrvoje, Gatin, Lucija, Grsic, Kresimir, Radojković, Ika Gugić, Jelčić, Ivan, Kastelan, Zeljko, Kolak, Juraj, Kulis, Tomislav, Kunjko, Kristian, Maric, Marjan, Kavanagh, Marcel Marjanović, Milicic, Borna, Morić, Trpimir, Pasini, Miram, Penezić, Luka, Prgomet, Drago, Prstacic, Ratko, Prtorić, Andreja, Radojković, Rudolf, Romić, Ivan, Sečan, Tomislav, Šoša, Dora škrljak, Slipac, Juraj, Tomic, Mislav, Zedelj, Jurica, Zekulić, Toni, Zimak, Zoran, Lorencin, Mia, Luksic, Ivica, Mamic, Matija, Espinsa, Norberto Miranda, Cruz, Ailén Sánchez, Antoniou, Stavros A., Kakas, Michael, Panayiotou, Yiannis, Almezghwi, Heyam, Arslan, Kalbim, Besim, Hasan, Özant, Ali, Özçay, Necdet, Kokkinos, Georgios, Papatheodorou, Panayiotis, Pozotou, Ioanna, Stavrinidou, Olga, Yiallourou, Anneza, Burda, Lukáš, Dosoudil, Michal, Martinek, Lubomir, Gawel, Wladyslaw B., Lerch, Milan, Peteja, Matúš, Žatecký, Jan, Daniel, Toman, Formánek, Martin, Javurkova, Veronika, Kepičová, Markéta, Macečková, Nicole, Matousek, Petr, Simetka, Ondrej, Vavra, Petr, Zelenik, Karol, Černý, Jan, Khan, Sami, Lischke, Robert, Přibyl, Martin, Younus, Temoore, Amarasena, Yenuksha, Klíma, Karel, Pirmorad, Setareh, Hotová, Zuzana, Mladěnka, Aleš, Bozo, Nulvin, Harbjerg, Julie Lykke, Hviid, Louise, Kristensen, Helle ø, Mekhael, Mira, Nielsen, Mette Fugleberg, Paulsen, Laerke, Sinimäki, Saija, Mogensen, Louise Zinck, Bonde, Peter, Ebbehøj, Anders Lyng, Fenger, Anne‐sophie, Haugstvedt, Aleksander Fjeld, Hansen, Christine Hangaard, Jönsson, Maria Lovisa, Jorgensen, Lars N, Krarup, Peter‐martin, Lihn, Anne‐louise, Meyhoff, Christian, Otte, Helena, Amar, Anas Ould Si, Palm, Henrik, Schlesinger, Nis, Smith, Henry, Tryggedsson, Ida, Axelsen, Anne Reiss, Bælum, Jens Kristian, Ellebaek, Mark Bremholm, Ellebæk, Signe Bremholm, Hogh, Anders, Acosta, Maria, Acosta, Yancy, Baez, Pedro, Betances, Luis Alfredo, Bonilla, Luis Rodolfo, Cabreja, Daniel, Cruz, Wilton Cabrera, Expósito, María Mabel Collado, Crespo, Aldo, Cruz‐pineda, Octavio, D’óleo García, Claudio Samuel, Díaz, Pedro, Escoto, Remberto, Figueroa, Jatnna, Garcia, Luis, Rodriguez, U Garcia‐Dubus, Gomez, Humberto, Grullon, Adrian, Guerrero, Fatherin, Guzman, Lillian, Mosquea, Thelma Rocío Jiménez, Lazala, Engels, Lopez, Ariela, Francisco, Leeany Maletta, Mercado, Jhomayri, Munoz, Herisardy, Paulino, Jeffrey, Fernandez, Maricely Ambar Perez, Reyes, Rudeily, Guilamo, Lilia Rosa Reyes, Rivas, Ruben, Torres, Claudia Alejandra Rivas, Rodríguez, Ada, Villa, Madelin Tamar Rosario, Santana, Eleazar, Soto, Joel, Tactuk, Nassin, Sardiñas, Cristina Kristel Tonos, Ubinas, Raul, Victoria, Jose, Villegas, Aaron, Acra‐tolari, Ricardo, Beltran, Larissa, Betances, Luis Fernand, Blaubach, Alejandro, Mejía, Denisse Idalia Campos, Capellan, Nathalia, Bruzual, María Fernanda Cedeño, Spencer, Saray Cordero, Lantigua, Gabriella Cuevas, De Jesus, Luis, Díaz, Gabriela, Vásquez, Pedro Pablo Díaz, Disla, Karla, Uceta, Jesús Antonio Echavarría, Jimenez, Paola Irina Eusebio, Fernandez, Damaris, Camilo, Marlin Fernandez, Germosen, Jiomar Manuel Figueroa, Fortunato, Maruel, Fernández, Leyla Gabriel, Dihmes, Alicia German, Herrera, Héctor, Cuevas, Elizabeth Leon, Mata, Jose Alejandro, De La Cruz, Mirian Mateo, De la Cruz, Dolores Mejia, Mirambeaux, Marcos, De La Cruz, Fabio Ortiz, Paulino, Henry, Pelletier, Gabriela, Pichardo, Merycarla, Enrique, Rodriguez Pumarol Próspero, Rivas, Julio, Marmolejos, Ann Stephany Sanchez, Santana, Roman Santana, Almanzar, Irina Suero, Sánchez, María Magdalena Vásquez, Campuzano, Nicolás, Ocampo, José Ricardo Negrete, Armas, Maria, Guerra, Alvaro Santiago LeMarie, Vizcaya, Gustavo León, Abdelwahab, Omar Ahmed, Elmehrath, Ahmed O., Mostafa, Mohammed Ezzat, Amira, Gamal, Sallam, Ibrahim, Sherief, Mohamed, Abdelmajeed, Ahmed, Abdou, Mostafa, Shanab, Ahmed Abo, Abodeeb, Aya, Aboelkhel, Roger, Abosamak, Nour Eldin, Bakr, Amna Abou, Aboubakr, Samar, Abouelnagah, Yossof, Aboumadawy, Omar, Adel, Dina, Afifi, Nermeen, Ahmed, Sara, Ahmed, Abedelrahman, Sayed, Mohamed AL, Alberkamy, Abdelrahman, Aldahma, Mohamed, Ali, Ahmed, Ali, Mostafa, Bakr, Mohamed Amin, Anter, Alaa, Asal, Doaa, Ashoush, Fouad, Ashraf, Olfat, Ashraf, Abdel Rahman, Atta, Rewan, Badr, Salma, Bahaaeldin, Mohamed, Bastawesy, Mostafa, Darwish, Sara, El Kharashy, Rasha, Elassar, Ziad, Elbadawy, Seifeldin, Elkhity, Dina, Elsaka, Alromisaa, Elsayed, Manal, Hewalla, Mostafa Elsayed Elsayed, Elshafey, Mohamed, Eshac, Youssof, Eshac, Fares, Essameldin, Amr, Ewedah, Moataz, Ezz, Yara, Farag, Mohamed, Gadelkarim, Inas, Gadelrab, Ziyad, Gamal, Dina, Ghaly, Mira, Girgis, Nathalie, Gouda, Omar, El Goweini, Nancy H., Hafez, Nour, Hafez, Youssef, Abdin, Abdelkader Hamed, Hanno, Rodina, Hassanin, Aliaa, Hassanin, Mohamed, Hemead, Hanan M., Hemida, Abdelrahman, Hosain, Maher, Hossam, Ahmed, Aly, Hamza Hussein Aly Salama, Ibrahim, Mohamed, Ibrahim, Abdelrahman, Ibrahim, Nourhan, Hamouda, Noha Mohamed Salah Ibrahim Moussa, Iskander, Monica, Khalifa, Islam, Kotb, Mostafa, Mahmoud, Nada, Shabana, Alaa Mahmoud Abo, Mamdouh, Nora, Metwalli, Maram, Metwally, Khaled, Moghazy, Mahmoud, Mohamed, Moustafa, Mourad, Mohamed, Moustafa, Esraa, Mubarek, Kamilia, Nader, Nour Eldin, Nasser, Ahmed, Omar, Samaa, Qatora, Mostafa Shehata, Ragab, Mohamed, Ragal, Marawan, Ramadan, Dina, Ramadan, Rana, Ramadan, Sara, Romany, John, Sabry, Ahmed, Said, Yasmeen, Salamah, Sara, Saleh, Ahmed Mostafa, Elkaffas, Mona Saleh Mesbah Mohamed, Salem, Alaa, Salim, Hashem, Samih, Ahmed, Abdelaal, Ahmed Samir, Shaheen, Ahmed, Mohammed, Yassmeen Sharafeldin, Shehata, Abdelrahman, Shemeis, Mohamed, Shenit, Karim, Sheta, Mennatallah, Soffar, Asmaa, Tanas, Yousef, Tarek, Ahmed, Yehia, Nermin, Eid, Omar Khaled Mohamed, Abdulfattah, Ammar Yasser, Elsaghir, Ahmed, Elganainy, Mohamed Fouad, Elsayed, Omar Ibrahim, Elmandouh, Omar, Hamam, Omar, Shehata, Mostafa Ahmed, Abdelaziz, Areej A., Abbas, Ahmed M., El‐ghani, Wael Abd, Abd Elazeem, Hossam Aldein S., Elsayed, Mustafa Abd, Abd‐elkariem, Ahmed Yassien, Abdalla, Shimaa, Abdel‐aleem, Mahmoud, Abdelazeem, Khaled, Abdelfattah, Mahmoud, Abdelhafez, Mohammed, Abdelkarem, Mohamed M., Abdelraouf, Ali, Abdullaha, Lamess, Abubeih, Hossam, Ahmed, Moaiad Eldin, Ahmed, Nagm Eldin Abu Elnga, Ahmed, Ahmed, Saad, Sarah Ahmed, Alaa, Sherif, Alhussaini, Ali, Ali, Abdelrahman Ahmed Abdelrahman, Ali, Ibrahim, Ali, Wagdi, Mohamed, Mohamed Ali, Ashraf, Mohamed, Bassiouni, Muhammad, El‐adawy, Mohamed G., El‐sharkawi, Mohammad, Elkhayat, Hussein, Elmaghraby, Khaled, Elsdfy, Shady, Elsharkawy, Mohamed, Eltayeb, Almoutaz, Mohamed, Mohamed Esmat, Essam, Esraa, Fahd, Mahmoud, Farouk, Osama, Gadelkareem, Rabea, Ghoneim, Ahmed, Takrouney, Mohammed Hamada, Hamdan, Ahmed, Hamed, Abd El‐Rahman, Hasan, Ahmad, Hassanin, Mohamed Abdelghafor, Hawal, Islam, Henes, Kerollos, Herdan, Mohamed Omar, Hetta, Helal F., Ibrahem, Omar, Ibrahim, Mostafa, Ibrahim, Islam H., Kamel, Mahmoud, Khallaf, Mohamed, Elghazaly, Shrouk M., Mahfouz, Abobakr, Mahmoud, Osman, Mahran, Wesam, Mahrous, Doha, Marsis, Abadeer, Mohamed, Ayman, Hussein, Aliae Mohamed, Sayed, Amr Mohamed, Mohammed, Mahmoud M, Mokhtar, Ahmed, Monib, Fatma A., Nageeb, Ahmed, Nageh, Mariam Albatoul, Nageh, Mohammed, Omar, Nehal Gamal, Ragab, Abdelrahman, Ramadan, Abdelrahman, Temerik, Abdallah Rashad, Sabry, Aya, Safwat, Hadeer, Salah, Omar, Mahmoud, Ahmed Elhussiny Salah, Saleh, Ahmed, Sallam, Mahmoud, Samir, Ahmed, Sayad, Reem, Sayed, Esraa, Sedik, Ahmed S., Shahine, Mohammed, Soliman, Antonios, Soliman, Wael, Taher, Mohamed Gamal, Wanees, Randa, Yousof, Ebrahim Ahmed, Youssef, Ahmed, Elabedeen, Omar Zein, Hassan, Ahmed Emad Sayed, Fattah, Shrouk Abdel, Abostate, Ahmed, Ali, Samar, Salama, Saad Ali Saad, Allam, Mohamed, Alsadek, Ahmed, Arafa, Ebrahim, Barakat, Ahmed, El Sherpiny, Mohammed, Elbehairy, Gehad, Eleisawy, Mahmoud, Elgendy, Abdelrahman, Elhawary, Rewan, Eltregy, Sherif, Hamdy, Mahmoud, Hassan, Gehad, Khalifa, Aya, Mahmoud, Ahmed, Altukhy, Ahmed Mohamed, Noah, Kareem, Noureldin, Yasser, Nowar, Mostafa, Saad, Moustafa, Elsaeidy, Ahmed Saad, Elsaeidy, Khaled Saad, Sabry, Hesham, Sameh, Mostafa, Said‐elnaby, Ahmed Tarek, Zahed, Mohamed, Zahran, Mohamed, Zaid, Abdelrahman, Zoghary, Ahmed Zaki, Atef, Mohamed, Mohamed, Ahmed, Youssef, Mohamed, Abdelhamid, Mahmoud Hossameldin Saad, Alazab, Emad, Awad, Ahmed K., Darwesh, Amr, El Fiky, Lobna, Elgarhy, Ibrahim, Nassef, Mohamed Adel, Shaban, Mahmoud, Shalaby, Mahmoud Mohamed Mohamed, Wahba, Abdelrahman, Fouad, Omar Youssif Omar, Elsadek, Menan, Gad, Dalia, Abdelsamed, Ahmed, Bayomy, Abdulhakeem, Elsalhy, Mohamed, Fahim, Ahmed, Seleim, Ahmed, Afifi, Eman, Gamal, Fatma Alzahraa, Gamal, Mennatullah, Eldesouky, Omnia, Eldwini, Mohamed Hatem Elmetwalli Eldwini, Fahmy, Mostafa Medhat Fahmy, Hussein, Ahmed, Ouf, Abdallah, Sami, Omar, Shaat, Salem, Bahi, Abdullah Wael Mostafa Khalil, Atea, Abdurhman, Gamal, Ibrahim, El Kassas, Mohamed, Omar, Wael, Tawheed, Ahmed, Al‐oribi, Saeid, Aly, Nuran Khaled, Elfiky, Mahmoud, Elmaghraby, Alaa Eldine, Elrahmany, Abdulrahman, Elsherbeeny, Motaz, Helmy, Youssef, Nabil, Ahmed, Farahat, Ahmed Samir, Soliman, Mostafa, Wassef, Amr, Abdelrahman, Abdelrahman, Elsaban, Seif, Ghaly, Galal, Hamdy, Rana, Mondy, Hamada, Abdallah, Lubna, Darwish, Abdelrhman KZ, Rabea, Mohamed, Azab, Mohammed A, Abbas, Alzhraa Salah, El‐deeb, Marwa, Fawzy, Mohamed, Ibraheem, Maher, Bakry, Abdelrahman, Elnems, Sarah, Elsheikh, Randa, Gbreel, Mohamed Ibrahim, Hafez, Mahmoud, Jammal, Mohamed, Hamam, Khaled M, Makram, Abdelrahman M, Makram, Omar Mohamed, Rabie, Salma, Askalany, Sherine Yousery, Abushanab, Mokhtar Mohamed Ibrahim, Eid, Abdulrahman, El Ghalid, Mohammed Refaat Ibrahiem Amin, Abdelaty, Ahmed Adel, Fayad, Elsayed A., Radwan, Asmaa, Sallam, Moataz, Shokry, Ahmad, Farouk, Ahmed Mohamed, Elfallal, Ahmed, Elfeki, Hossam, Elsaeed, Mohamed, Elsaid, Mahmoud, Makroum, Amany, Elsaid, Dina Mohamed, Mostafa, Mohamed, Omar, Mohamed W, Rezk, Mohamed, Sakr, Ahmed, Sanad, Aly, Shalaby, Mostafa, Shawqy, Mohammed, Shetiwy, Mohamed, Shoma, Ashraf, Tawakl, Noura, Yunes, Asmaa, Abouzid, Amr, Atallah, Khalid, Elmorsi, Rami, Elsherbini, Ahmed, Gaballa, Khaled, Hamdy, Omar, Hamdy, Mohamed, Metwally, Islam Hany, Refky, Basel, Shetiwy, Mosab, Zuhdy, Mohammed, Zahran, Mohammed A, Abdellah, Fatima, Abdelmawla, Ahmed, Abdrabou, Ahmed, Abubakr, Asmaa, Al Gohary, Rawda, Al‐shazly, Mohammed Hamdy, Ali, Mohamed, Allam, Abdallah R, Aposaeeda, Aya, Asfour, Mohammed, Ayman, Ammar, Omran, Abdelrahman Azzam, Daghash, Ibrahim Tawfiq, Ebada, Mahmoud Ahmed, Eid, Taher, El Kelany, Ahmed, El Shemy, Esraa, El‐hag‐aly, Mohammed, Elgamal, Omar, Elghoury, Mahmoud, Elkased, Ahmed Farag, Ellakwa, Takwa Hamed, Ellakwa, Hamed, Elmeanawy, Amr, Elnoamany, Salma, Elsabagh, Alaa, Elsawey, Abdelrahman, Elshabrawy, Enas, Elshakhs, Seliman, Elsoudy, Naira, Ezzat, Esraa, Fawzy, Ahmed, Gamal, Abrar, Gameel, Ahmed, Gharbia, Khaled, Ghonaim, Mohamed, Ghonaim, Alaa, Hafez, Ahmed, Hafez, Abdelrahman, Ismail, Zainab, Khaled, Mohamed, Meselhy, Mohammed, Mikhail, Pola, Mohamed, Mervat, Mougahed, Mohamed, Mustafa, Abdulla, Nada, Ahmed, Omran, Janna, Ebiad, Mohamed S., Saleh, Ibrahiem, Salem, Nourhan, Salem, Osama, Selim, Salma, Shalaby, Ghada, Sherif, Hoda, Soltan, Hatem, Wahbah, Mahmoud, Abdelbary, Eman Zakaria, Zayan, Ahmad Helmy, Afify, Abdelrahman, Hadiya, Hossam Ali, Elshref, Mohamed Jamal, Ahmed, Mostafa Mohamed, Nasser, Nourhan, Abdeldayem, Hesham, Salama, Ibrahim Abdelkader, Ammar, Khaled, Ayoub, Islam, Aziz, Amr, Badawy, Mohammad Taha, Balabel, Mohamed, Fayed, Yahya, Gad, Emad Hamdy, Gomaha, Maher, Hammad, Essam, Hegazy, Osama, Hegazy, Elsayed, Ibrahim, Tarek, Kallaf, Mostafa, Macshut, Mahmoud, Magdy, Ammar, Oteem, Ahmed, Sallam, Ahmed, Samaan, Samy, Sharshar, Mohamed, Shoreem, Hany, Soliman, Elsayed, Soliman, Hossam Eldeen, Yassein, Taha, Zakaria, Hazem, Eldaly, Abdullah, Mashaly, Sarah, Abd‐elsalam, Sherief, Abdel‐elsalam, Wafaa, Shaalah, Ahmed Abdullah, Elbahnasawy, Mohamed, Elhalaby, Ismael, Hamada, Mohamed, Soliman, Sarah Hamdy, Hawila, Ahmed, Morsy, Mohamed Sherif, Naieem, Mohmed, Nasreddin, Mohammed, Salman, Samar, Sarsik, Sameh, Shabana, Ahmed, Tolba, Engy, Zagho, Mohamed, Kams, Liisa, Rätsep, Tõnu, Riips, Karolin, Abdurehman, Oumer, Admasu, Azarias, Berhea, Ataklitie, Eado, Yegeremu, Hailu, Nebiyou, Kidane, Meklit, Mohammed, Abdurezak, Mohammed, Khalid, Tibelt, Admasu, Woldemariam, Mersha Abebe, Yonael, Lydya, Alemu, Megersa, Aklilu, Abenezer Tirsit, Asele, Frehun, Assefa, Solomon, Azmach, Dawit, Bekele, Philimon, Mamo, Mickyas, Maru, Nahom, Mekuria, Haile, Menkir, Abel, Mikru, Filagot, Siraw, Eyerusalem, Suga, Hilkiah, Sumoro, Natnael, Teka, Aklilu, Thomas, Efeson, Woldemariam, Dereje, Wubishet, Estifanos, Abebe, Engida, Abebe, Kirubel, Asfaw, Fitsum, Bergene, Eyerusalem, Eshete, Mahder, Gebrehiwot, Fitsum Gebreegziabher, Gedefaw, Yetsedaw, Mengesha, Mulualem Wondafrash, Mengiste, Netsanet, Menjeta, Abeje, Muleta, Mahteme Bekele, Sefera, Sena, Tedla, Yonatan, Teklu, Daniel, Teshome, Henok, Tirfe, Leake, Tsegabrhan, Sahle, Tsehaye, Milkias, Worku, Bereket, Molla, Million, Supha, Melka, Taye, Tewodros, Abebe, Nebyou, Alemu, Berhanu, Chanie, Abera, Degefu, Hailegebriel, Desalegn, Dawit, Gebre, Hiwot, Hussen, Husnia, Kassa, Dawit, Laeke, Tsegazeab, Mammo, Tihitena Negussie, Negash, Samuel, Sahlu, Abat, Tiruneh, Abraham Genetu, Wolde, Amanuel, Woldeselassie, Hanna Getachew, Ahmed, Mnewer Y., Zewdneh, Betelhem, Fentaw, Jibril, Salia, Shemsedin, Tabore, Ketema, Gurara, Addisalem, Abreha, Tassew, Abrha, Teklebirhan, Beyene, Gaym, Hailu, Niguse, Weldu, Mulu Atsbaha, Abdissa, Desalegn, Tesfaw, Mequannet, Wolle, Melatework, Asmamaw, Dawit, Assefa, Biniam Zemedu, Bedane, Dereje, Bekele, Ephrem, Getie, Aderaw, Melkamu, Solomon, Mengesha, Workineh, Shumye, Getachew, Tagele, Gashaye, Tesfa, Abrham Amare, Workneh, Wubshet, Genetu, Sileshi, Mebratu, Eneyew, Chanyalew, Lidya, Deresse, Tilahun, Girma, Adissu, Seid, Marta, Shimelash, Dagim, Shitaw, Abrham, Ayalew, Tewabe, Diress, Tesfaye, Kassahun, Berhanu, Kassaye, Bersabeh, Mulugeta, Esubalew, Tesfaw, Getasew, Yimenu, Beminet, Benecha, Semir, Aman, Mudesir, Ibrahim, Adem, Mekete, Alem, Tesemma, Abdi, Mohammed, Adnan Abdulkadir, Abdullahi, Yasir Younis, Adem, Ephrem, Ahmedin, Mahlet, Assefa, Yared, Ayde, Fitsum, Berhe, Alazar, Gebremeskel, Zersenay, Siyoum, Eneyew Getachew, Teresa, Sintayehu, Wude, Zinaye, Yemer, Fasika, Yohannes, Dagnachew, Zeleke, Ewunetu, Zerihun, Gulilat, Degefe, Derje Worku, Derilo, Hankore Tamirat, Eliyas, Nebiyu, Bayissa, Firew, Deressa, Yadani, Gemechu, Lidya, Gurmu, Tegenu, Kasaye, Ashenafi, Melese, Lemi, Muleta, Lemesa, Mulugeta, Gersam, Taye, Seifu, Teshome, Abraham, Tesso, Birhanu, Gebrekirstos, Gebreagziabher, Haile, Mhreteab, Kassa, Haftamu, Saddik, Mohammed, Mengist, Alemneh, Heikkinen, Juuso, Helminen, Olli, Huhta, Heikki, Kotkavaara, Tommi, Mosorin, Matti‐aleksi, Pitkänen, Joel, Qian, Cheng, Sinikumpu, Jaakko, Sova, Henri, Tastula, Mikko, Virta, Ville P, Bettoni, Jérémie, Dakpé, Stéphanie, Devauchelle, Bernard, Lavagen, Nolwenn, Bastard, François, Bin, Kim, Breheret, Renaud, Fouquet, Olivier, Gueutier, Alexandre, Henric, Nicolas, Kahn, Alexis, Kün‐darbois, Jean‐daniel, Moukoko, Didier, Pineau, Anna, Podevin, Guillaume, Schmitt, Françoise, Alshawared, Fadi, Beyrne, Carlos Daniel, Lugans, Laurene, Marie‐macron, Lysa, Doussot, Alexandre, Ahmed, Omar, Alnajjar, Louy, Mis, Tommaso Cipolat, Fliss, Souha, Giocanti‐auregan, Audrey, Gregory, Thomas, Guiraudet, Patrice, Le Fouler, Adrien, Martinod, Emmanuel, Onorati, Ilaria, Peretti, Marine, Quilichini, Julien, Radu, Dana, Trésallet, Tresallet, Andro, Christophe, Maffert, Alexis, Chapman, Tracy, Halden, Maxime, Fayon, Julie, Mattevi, Catherine, Marion, Herjean, Bendjemar, Lynda, Lionel, Charre, Mikhael, Elie, Macías, Rosa Montero, Villefranque, Vincent, Volpin, Enrico, Trilling, Bertrand, Boleslawski, Emmanuel, Constance, Houlzé‐laroye, Drubay, Vincent, El Amrani, Mehdi, Eveno, Clarisse, Lecolle, Katia, Martin, Louis, Noiret, Barbara, Piessen, Guillaume, Truant, Stephanie, Zerbib, Philippe, Aubry, Estelle, Denimal, Franck, Lamblin, Antoine, Barrat, Benjamin, Caire, François, Christou, Niki, Fourcade, Laurent, Laloze, Jerome, Bouv‐hez, Margaux Mekann, Salle, Henri, Taibi, Abdelkader, Tricard, Jeremy, Usseglio, Julie, Chopinet, Sophie, Gregoire, Emilie, Delpont, Marion, Blanchard, Claire, Crenn, Vincent, Vergie, Stéphane, Denis, Waast, Fragnaud, Henri, Regenet, Nicolas, Rigaud, Jerome, Varenne, Yoann, Anract, Philippe, Barat, Maxime, Biau, David, Dautry, Raphaël, Dohan, Anthony, Idier, Louis, Lang, Elena, Thouny, Camille, Tzedakis, Stylianos, Audenet, François, Cazelles, Antoine, Chamouni, Alexandre, Karoui, Mehdi, Mejean, Arnaud, Clermidi, Pauline, Langlais, Tristan, Leonelli, Lorenzo, Maisonneuve, Emeline, Nicolas, Beaud, Perrot, Ophelie, Prost, Doriane, Thomin, Anne, Thouement, Thouement, Athiel, Yoann, Berry, Richard, Boddaert, Guillaume, Bonnet, Stéphane, Cathala, Nathalie, Conso, Christel, Denet, Christine, Laforest, Anaïs, Levy‐zauberman, Yael, Macek, Petr, Mombet, Annick, Ollat, Didier, Scamporlino, Adriana, Zadegan, Frederic, Amine, Chamakhi Ahmed, Baratte, Baratte, Chartier‐kastler, Emmanuel, Chereau, Nathalie, Colas, Pierre‐antoine, Duquesne, Igor, Genser, Laurent, Petit, Gaëlle Godiris, Goumard, Claire, Hasani, Ariola, Lim, Chetana, Martellotto, Sophie, Melot, Charlotte, Menegaux, Fabrice, Pinar, Ugo, Pocard, Marc, Roupret, Morgan, Scatton, Olivier, Seisen, Thomas, Séverine, Noullet, Turco, Célia, Chouillard, Elie, Beganton, Paul, Frasca, Denis, Kerforne, Thomas, Corbiere, Lisa, Gasmi, Anis, Ghemame, Marwane, Guérin, Sonia, Khene, Zine‐eddine, Livin, Marie, Mahmoud, Fedy, Maillot, Betty, Merdrignac, Aude, Mouriaux, Frederic, Robin, Fabien, Sulpice, Laurent, Vazeux, Charles, Bertheuil, Nicolas, Bonneau, Soline, Cazemajou, Clément Thierry, Cousin, Ianis, Defert, Coralie, Fustec, Elisa, Juricic, Melodie, Lavoue, Vincent, Mevel, Gwenaël, Timoh, Krystel Nyangoh, Renault, Annaëlle, Violas, Philippe, Schwarz, Lilian, Tuech, Jean Jacques, Morichau‐beauchant, Tristan, Sauvat, Frederique, Haddad, Elie, Vermersch, Sophie, Patrizi, Andrea, Roux, Alexia, Aimé, Adeline, Malgras, Brice, Cherkaoui, Zineb, D’Urso, Antonio, Felli, Emanuele, Gonzalez, Cristians Alejandro, Ignat, Mihaela, Mutter, Didier, Pessaux, Patrick, Vix, Michel, Gornes, Hugo, Vergriete, Kélig, Berthoumieu, Pierre, Genre, Ludivine, Le Gall, Hélène, Pierre, Trocard, Chalhoub, Marc, Del, Mathilde, Martinez, Alejandra, Fuchs‐buder, Thomas, Vancon, Antoine, Faya, Camara Abraham, Asaph, Elvam, Baruwa, Elisee, Hofman, Gwen, Machemedze, Solomon, Idiata, Michael Mayombo, Muhemi, Roger, Ndizeye, Olivier, Nkunzimana, Elysé, O’Connor, Jennifer, O’Connor, Zachary, Tchoba, Simplice, Boumas, Natacha, Devidze, Grigol, Pisarevi, Givi, Baumgarten, Sabine, Grüßer, Linda, Hölzle, Frank, Kowark, Pascal, Kowark, Ana, Rossaint, Rolf, Schäfer, Benedikt, Wallqvist, Julia, Winnand, Philipp, Ziemann, Sebastian, Anthuber, Matthias, Broecheler, Tobias, Edlinger, Florian, Goßlau, Yvonne, Hyhlik‐duerr, Alexander, Maksymiw, Florian, Shiban, Ehab, Sommer, Florian, Sommer, Björn, Zerwes, Sebastian, Beyer, Katharina, Lauscher, Johannes Christian, Lee, Lucas D., Loch, Florian N, Schineis, Christian, Aghalarov, Ilgar, Belyaev, Orlin, Braumann, Chris, Enste, Annika, Fahlbusch, Tim, Herzog, Torsten, Horn, Julian, Jedanowski, Julia, Knipschild, Julia, Luu, Andreas Minh, Mohan, Prem Vignesh, Siemen, Leonie, Slobodkin, Illya, Strotmann, Johanna Josefine, Uhl, Waldemar, Wolf, Katerina, Coburn, Mark, Egger, Eva, Eichhorn, Klaus, Enderes, Jana, Far, Frederick, Franzen, Alina, Güresir, Erdem, Hadjiathanasiou, Alexis, Kalff, Jörg C., Kohistani, Zaki, Manekeller, Steffen, Mustea, Alexander, Probst, Chris, Randau, Thomas, Recker, Florian, Schuss, Patrick, Straßberger‐nerschbach, Nadine, Strieth, Sebastian, Treede, Hendrik, Beekum, Cornelius J., Vatter, Hartmut, Velten, Markus, Vilz, Tim O., Wirtz, Dieter, Wittmann, Maria, Behr, Michael, Bulian, Dirk Rolf, Marche, Benedikt, Moczko, Tobias, Otchwemah, Robin, Schulz, Sissy‐amelie, Thomaidis, Panagiotis, Bruns, Christiane, Cursiefen, Claus, Domröse, Christian, Fuchs, Hans, Heindl, Ludwig Maximilian, Mallmann, Michael R., Mallmann, Christoph, Ratiu, Dominik Alexander, Canzler, Ulrich, Distler, Marius, Korn, Sandra, Meisel, Cornelia, Meusel, Marcus, Petzold, Andrea, Praetorius, Christian, Renesse, Janusz, Weitz, Juergen, Wimberger, Pauline, Alkhanji, Nour, Fung, Stephen, Jaber, Kefah, Knoefel, Wolfram Trudo, Vay, Christian, Clonda, Octavian, Cottin, Tatiana, 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Lorenz, Kerstin, Papendick, Nancy, Plontke, Stefan, Seiwerth, Ingmar, Steer, Susanne, Thomssen, Christoph, Ukkat, Jörg, Dumpies, Christian W., Fischer, Isabel, Gessner, Michael, Hanke, John, Klauke, Friederike, Leuschner, Sebastian, Mendel, Thomas, Müller, Katharina, Schmidt, Birte, Schreiter, Valentin, Stosberg, Peter, Vinz, Franziska, Herbig, Beate, Sander, Johannes, Schulte, Thilo Maria, Betz, Christian Stephan, Bewarder, Julian, Bier, Johannes, Böttcher, Arne, Burg, Simon, Busch, Chia‐jung, Bußmann, Lara, Gosau, Martin, Heuer, Annika, Izbicki, Jakob, Klatte, Till Orla, König, Daniela, Köpke, Leon‐gordian, Moeckelmann, Nikolaus, Praetorius, Mark, Priemel, Matthias, Stadlhofer, Rupert, Stangenberg, Martin, Uzunoglu, Faik G., Wittig, Lukas, Zech, Henrike, Zeller, Nina, Roux, Frederic, Spaeth, Tsiona, Fricker, Roland, Müller, Thomas, Schröder, Lars, Alasmari, Mohammed, Boeker, Clara, Hakami, Ibrahim Abdullah, Mall, Julian W, Kyritsis, Ioannis, Graeb, Christian, Huber‐strößner, Kristin, Branzan, Daniela, Doss, Markus, Gockel, Ines, Jödicke, Carolin, Osterhoff, Georg, Pempe, Christina, Sucher, Robert, Adler, Tina, Kelly, Kathrin, Merkle, Janica, Siebert, Julia, Hirche, Christoph, Kneser, Ulrich, Tapking, Christian, Agrawal, Rachit, Qureischie, Homeira, Croner, Roland, Koslowski, Lisa, Krause, Hardy, Meyer, Frank, Turial, Salmai, Al‐nawas, Bilal, Battista, Marco Johannes, Goedeke, Jan, Hasenburg, Annette, Heider, Julia, Mueller, Lena Katharina, Zeller, Simon, Jentschura, Sina Louisa Patrizia, Kowalewski, Karl‐friedrich, Kriegmair, Maximilian, Männle, David, Reissfelder, Christoph, Rotter, Nicole, Scherl, Claudia, Seyfried, Steffen, Kirschniak, Andreas, Rolinger, Jens, Wilhelm, Peter, Bader, Franz G., Ottl, Stephanie, Behr, Alexandra Viktoria, Diamantis, Alexandros, Fichter, Andreas, Grill, Florian, Heck, Matthias, Jira, Daniel, Kallmayer, Michael, Koll, Florestan, Luhne, Stefan, Meyer, Bernhard, Patachia, Robert, Pergolini, Ilaria, Safi, Seyer, Schäffer, Christoph, Schirren, Moritz, Wegmann, Helmut, Wirth, Markus, Zhu, Zhaojun, Aghamaliyev, Ughur, Almaghrabi, Mahmoud, Böcker, Wolfgang, Bruder, Jan, Frank, Konstantin, Herterich, Viktoria, Huber, Verena, Ilmer, Matthias, Kammerlander, Christian, Neuerburg, Carl, Ehrlich‐treuenstätt, Viktor H., Werner, Jens, Börner, Nikolaus, Fegg, Florian, Hartmann, Daniela, Ladurner, Roland, Liokatis, Paris, Patzer, Kathrin, Schlager, Justin Gabriel, Smolka, Wenko, Zimmermann, Petra, Hatz, Rudolf, Steinhart, Diana, Glowalla, Claudio, Schneidmueller, Dorien, Henkel, Karl Wilhelm, Steiner, Martin, Hölz, Katharina, Knorr, Christian, Kuehlmann, Britta, Oikonomou, Kyriakos, Prantl, Lukas, Flurschütz, Roland, Honarpisheh, Human, Kröger, Marie, Lepiorz, Dominic, Luths, Charlotte, Niemeier, Andreas, Sras, Yara, Strate, Tim, Winter, Thore, Freiman, Thomas, Gessler, Florian, Won, Sae‐yeon, Widyaningsih, Rizky, Hoffmann, Sebastian, Schäfer, Ruth Christine, Thiel, Johannes Tobias, Bertolani, Elisa, Steidle, Christoph, Überrück, Lisa, Yurttas, Can, Ziegler, Patrick, Zimmermann, Alexander, Bolenz, Christian, Dayan, Davut, Greve, Jens, Hoffmann, Thomas K., Janni, Wolfgang, Löbig, Niklas, Schochter, Fabienne, Vahl, Julius Malte, Wezel, Felix, Greif, Veronika, Schmidbauer, Stefan, Marsch, Imke, Schneider, Rolf, Boenicke, Lars, Degener, Stephan, Dreger, Nici Markus, Horstmeier, Franz Christian, Kruschwitz, Jakob, Rombach, Adrian, Schmidt, Nele, Seiberth, Rose, Singh, Jaswinder, Smit, Marieke, Rundstedt, Friedrich‐carl, Zirngibl, Hubert, Diessner, Joachim, Friedrich, Sabine, Germer, Christoph‐thomas, Helmer, Philipp, Herrmann, Johannes, Kranke, Peter, Kübler, Hubert, Lock, Johan, Lotz, Christopher, Meffert, Rainer, Meybohm, Patrick, Müller, Sophie, Notz, Quirin, Popp, Maria, Schlegel, Nicolas, Schlesinger, Tobias, Schmid, Benedikt, Sitter, Magdalena, Steinisch, Andreas, Treutlein, Agnes, Berg, Anne, Wurmb, Thomas Erik, Agyeman‐duah, Nana Kwaku, Appiah, Enoch, Armah, Ralph, Asare, Christopher, Awere‐kyere, Lawrence, Daary, Dennis, Gakpetor, Delali, Allah, Stephen Minlah, Obbeng, Ambe, Osei‐poku, Dorcas, Puozaa, Diana, Tackie, Enoch, Adu‐aryee, Nii Armah, Agboadoh, Nelson, Asare, Offei, Bowan, Antoinette Bediako, Brown, George Darko, Clegg‐lamptey, Joe‐nat, Dedey, Florence, Dery, Cedric, Fenu, Benjamin Sena, Harrison, Marian Abedua, Kumassah, Philemon, Kuuzie, Ekins, Nsaful, Josephine, Olayiwola, David Olatayo, Smith, Cecilia, Banka, Charles, Hussey, Romeo, Azize, Diallo Abdoul, Aniakwo, Luke Adagrah, Adofo‐asamoah, Yvonne, Agbeno, Evans Kofi, Agyapong, Meshach Manu, Agyen, Thomas, Mensah, Kwasi Agyen, Alhassan, Baba Alhaji Bin, Amoako‐boateng, Mabel, Appiah‐thompson, Peter, Gyimah, Nita Asamoa‐Manu, Asante‐bremang, Moses, Asante‐asamani, Alvin, Atawurah, Henry, Appiah, Anthony Baffour, Baidoo, Richard Ogirma, Baidoo, Ebikela Ivie, Boakye, Benedict, Boateng, Abigail, Dadoe, Dora, Dayie, Makafui Seth Caleb‐Joshua Kwasi, Debrah, Samuel, Doku, Kingsley, Enti, Enti, Ken‐amoah, Sebastian, Koggoh, Patience, Kpangkpari, Richard, Maison, Patrick, Mensah, Samuel, Mensah, Philip, Mensah, Teresa Aba, Morna, Martin Tangnaa, Nimako‐mensah, Jilac, Nkrumah, John, Nortey, Michael, Ofori, Emmaunel Owusu, Opandoh, Isabella Naa Morkor, Osei‐tutu, Ethel, Adae, Jefferson Owusu, Quansah, Kofi, Quartson, Elizabeth, Rahman, Ganiyu Adebisi, Walawah, David, Yigah, Makafui, Yussif, Safia, Jiagge, Nuna, Nachelleh, Emmanuel, Acquaye, Jane, Agbedinu, Kwabena, Agyei, Fareeda, Agyemang‐prempeh, Akosua, Amo‐antwi, Kwabena, Amoah, Michael, Amoah, George, Amoako, Yaw A, Aning, Daniel Gyawu, Ankobea‐kokroe, Frank, Mintah, Dominic Annor, Anyitey‐kokor, David, Appiah‐kubi, Adu, Arthur, Joshua, Ativor, Vincent, Barnor, Isaac, Braimah, Yasmine, Darko‐asante, Regina, Davor, Anthony, Issahalq, Mohammed Duah, Dzogbefia, Mawutor, Emile, Tano, Fiifi‐yankson, Papa, Gaveh, Valerie, Gudugbe, Senyo, Gyabaah, Solomon, Gyamfi, Frank Enoch, Gyedu, Adam, Gyimah, Derrick, Hammond, Bernard, Jonathan, Boakye‐yiadom, 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Manatakis, Dimitrios K., Stamos, Nikolaos, Tasis, Nikolaos, Arkadopoulos, Nikolaos, Danias, Nikolaos, Economopoulou, Panagiota, Frountzas, Maximos, Kokoropoulos, Panagiotis, Michalopoulos, Nikolaos, Selmani, Jonida, Sidiropoulos, Theodoros, Vassiliu, Panteleimon, Paraskevas, Kosmas I., Bartziotas, Dimitrios, Bouchagier, Konstantinos, Galanis, Ilias, Kalamatianos, Theodosis, Kapiris, Stylianos, Kolinioti, Angeliki, Mavrodimitraki, Eleni, Metaxas, Panagiotis, Nikova, Alexandrina, Psarologos, Michail, Sotiropoulou, Maria, Stranjalis, George, Albanopoulos, Konstantinos, Kondilis, Panagiotis, Vrakopoulou, Gavriella Zoi, Chrysovergis, Aristeidis, Chrysovitsiotis, Georgios, Giotakis, Evangelos, Kanellopoulou, Vasiliki, Kyrodimos, Efthymios, Larentzakis, Andreas, Pantos, Pavlos, Papanikolaou, Vasileios, Potamianos, Spyridon, Theodoropoulos, Charalampos, Triantafyllou, Alexandra, Triantafyllou, Tania, Georgousi, Kleoniki, Panagiotou, Peter, Avramidis, Emmanouil, Babis, George, Zafeiris, 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Panagiotis, Skolarikos, Andreas, Theochari, Nikoletta, Tzelves, Lazaros, Gaitanakis, Stylianos, Milas, Theodoros, Theodorakis, Emmanuel, Karona, Paraskevi, Kastanaki, Pagona, Tzouganakis, Angelos, Agalianos, Christos, Tsouknidas, Ioannis, Xenakis, Andreas, Chrysos, Emmanuel, Lasithiotakis, Konstantinos, Nikolouzakis, Taxiarchis, Xenaki, Sofia, Xynos, Evangelos, Lostoridis, Eftychios, Nagorni, Eleni‐aikaterini, Pujante, Antonio, Tourountzi, Paraskevi, Aggeliki, Al, Baxevanidou, Kyriaki, Bouliaris, Konstantinos, Efthimiou, Matheos, Kalfountzos, Christos, Koukoulis, Georgios, Lachanas, Vasileios, Petropoulos, Konstantinos, Tsitiridis, Ioannis, Angelis, Fragkiskos, Arnaoutoglou, Eleni, Baloyiannis, Ioannis, Bareka, Metaxia, Bouronikou, Anna, Christodoulidis, Gregory, Daponte, Alexandros, Fergadi, Maria, Gkolias, Nick, Gkrinia, Eleni, Hajiioannou, Jiannis, Kalogritsas, Nikos, Karoni, Eleni, Korais, Christos, Krestinidis, Giorgos, Ktisti, Antigoni, Magouliotis, Dimitrios, Maiou, Charikleia, Malizos, Konstantinos, Minasidou, Maria, Ntalouka, Maria, Ntziovara, Anna Maria, Palla, Effrosyni, Perivoliotis, Konstantinos, Saini, Fani, Samara, Athina, Saratziotis, Athanasios, Skoulakis, Charalampos, Solomi, Efthymios, Stamoulis, Konstantinos, Terzoudis, Christos Dimitrios, Tsironi, Evangelia, Tzovaras, George, Vallianou, Kyriaki, Zacharoulis, Dimitris, Ziogkou, Anna, Δακής, Κωνσταντί__ς, Elias, Liolis, Maroulis, Ioannis, Mulita, Francesk, Plachouri, Kerasia‐maria, Vailas, Michail, Doitsidis, Charalampos, Filo, Eva, Gkalonaki, Ioanna, Kogia, Eleni, Kontopoulou, Konstantina, Mitroudi, Magdalini, Panteli, Christina, Patoulias, Ioannis, Semkoglou, Olga Ioulia, Sfoungaris, Dimitrios, Valioulis, Ioannis, υτσ_υ μης, Γι ωργος, Astreidis, Ioannis, Christidis, Panagiotis, Ioannidis, Orestis, Loutzidou, Lydia, Mantevas, Antonis, Paraskevopoulos, Konstantinos, Tatsis, Dimitris, Athanasiadis, Apostolos, Dagklis, Themistoklis, Kalogiannidis, Ioannis, Kapetanios, Georgios, Mamopoulos, 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Tulio Torres, Villeda, Sergio Alejandro, Anicetti, Joshua, Medina, Andrea Michelle Lowey, Ardebol, Javier, Barillas, Kathia, De Leon, Francis, Recinos, Salvador, Marroquin‐alpirez, Miguel‐angel, Yax, Yessica, Hon, Sophie, Liu, Yuk Ho, Liu, Alex Qinyang, Liu, Shirley, Chiu, Hei Tung Natalie, Chow, Chi Man Tom, Hau, Victor, Ho Wai, Ip, Mak, Brian, Mok, Chung Ying, Dennis, Ng, Siu, Yin Yu Eva, Wong, Kiu Fung, Jingya Jane, Pu, Yu‐xiong, Su, Au‐yeung, Kit Ying, Chan, David Yuen Chung, Chan, Albert, Chan, Shannon Melissa, Chang, Tsz Ching, Chiu, Tor Wo, Chiu, Wang Kei, Zhexi, He, Man Fung, Ho, Kevin Ki Wai, Ho, Jacky Yan Kit, Ho, Kung, Janet Wui Cheung, Lam, Cheuk Ho, Lau, Rainbow W. H., Ling, Samuel Ka Kin, Lok, Hon Ting, Mak, Tony Wing Chung, Chi‐fai, Ng, Simon, Ng, Kelvin Kwok‐Chai, Ng, Calvin S. 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M. M. 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Priyadarshini, Suganya, S, Samuel, Habie, Samuel, Gilbert, Selvaraj, Daniel, Sharma, Srujan, Surendran, Suraj, Hariharan, T D, Thangaraj, Santhosh Kumar, Thomas, Vinotha, Thomas, Varghese, Thomas, John K, Harish, Y S, Boggavarapu, Manobhiram, Voonna, Murali Krishna, Lolobali, Marilaeta Cindryani, Ryalino, Christopher, Senapathi, Tjokorda Gde Agung, Tjokorda, Mahadewa, Widnyana, I Made Gede, Aditianingsih, Dita, Auerkari, Aino, Chandra, Susilo, Damara, Fachreza Aryo, Dilmy, Mohammad Adya Firmansha, Harzif, Achmad Kemal, Manggala, Sidharta Kusuma, Pratama, Dedy, Priyambodo, Affan, Ramlan, Andi Ade, Soenarto, Ratna Farida, Sugiarto, Adhrie, Surya, Ilham Utama, Tango, Tamara, Tantri, Aida Rosita, Zahra, Raihanita, Fachrian, Dedy, Hasyim, Andi, Susanti, Ade, Saputra, Teddy, Syarifuddin, Erwin, Islam, Andi Asadul, Pajan, Hendra, Amrullah, Ahmad Hannan, Anam, Khoirul, Hadipranata, Thirza, Sugianto, Julius Albert, Fitrisyah, Aidyl, Lestari, Mayang Indah, Lubis, Nur Rachmat, Zainal, Rizal, 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Ahmad, Gatot, Inbar, Gavriel, Haim, Gold‐deutch, Ruthie, Haim, Nadav, Hammerschlag, Jonathan, Hershkovitz, Yehuda, Jaber, Ahmad, Kenoshi, Adi, Lavy, Ron, Majadla, Omar, Muallem‐kalmovich, Limor, Nativ, Hilli, Rabin, Igor, Sandler, Yael, Zmora, Osnat, Bala, Miklosh, Demma, Yonatan Avraham, Fishman, Yuri, Marom, Gad, Avni, Naor, Carmel, Ofra, Farkas, Amicur, Freund, Michael Ron, Gonen, Lior, Gozal, Yaacov, Greenman, Dmitry, Kocherov, Stanislav, Margalit, Nevo, Shick, Orit Nahtomi, Ostrovsky, Israel Alexander, Pardes, Rivka, Perets, Michal, Shahar, Tal, Shapiro, Henry, Tankel, James, Teren, David, Yahud, Reuven, Yellinek, Shlomo, Balercia, Paolo, Catarzi, Lisa, Consorti, Giuseppe, Cianci, Pasquale, Gattulli, Domenico, Minafra, Marina, Restini, Enrico, Andolfi, Enrico, Annino, Filippo, Barbara, Frezza, Biancafarina, Alessia, Bussolin, Edoardo, De Prizio, Marco, Gjondedaj, Ulpjana, Gubbiotti, Marilena, Mura, Gianni, Pellicano, Giuseppe Antonino, Pirola, Giacomo Maria, Sulce, Rezart, Martines, Gennaro, Papagni, Vincenzo, Picciariello, Arcangelo, Magnone, Stefano, Pisano, Michele, Poiasina, Elia, Alberici, Laura, Antonacci, Filippo, Arena, Alessandro, Belvedere, Angela, Bernagozzi, Fabio, Bernante, Paolo, Bertoglio, Pietro, Bianchi, Lorenzo, Bisulli, Maria, Bonfanti, Barbara, Boussedra, Safia, Brandolini, Jury, Cacciapuoti, Crescenzo, Cardelli, Stefano, Casadei, Riccardo, Cescon, Matteo, Cipolli, Alessandro, Cipriani, Riccardo, Contu, Luca, Costa, Francesco, Daddi, Niccolo, De Crescenzo, Eugenia, De Iaco, Pierandrea, De Palma, Alessandra, Del Gaudio, Massimo, Gatta, Anna Nunzia Della, Dolci, Giampiero, Dondi, Giulia, Droghetti, Matteo, Parri, Sergio Nicola Forti, Garelli, Elena, Gelati, Chiara, Germinario, Giuliana, Giorgini, Federico A., Ingaldi, Carlo, Jovine, Elio, Kawamukai, Kenji, Lanci, Antonio Lanci, Lombardi, Raffaele, Miralles, Maria Elisa Lozano, Marchetti, Claudio, Masetti, Michele, Minni, Francesco, Morezzi, Daniele, Parlanti, Daniele, Pellegrini, Alice, Perrone, Anna Myriam, Pezzuto, Anna Paola, Pignatti, Marco, Pilu, Gianluigi, Pinto, Valentina, Poggioli, Gilberto, Puglisi, Silvana Bernadetta, Raimondo, Diego, Ravaioli, Matteo, Ricci, Claudio, Ricciardi, Sara, Ricotta, Francesco, Rizzo, Roberta, Romano, Angela, Rottoli, Matteo, Schiavina, Riccardo, Seracchioli, Renato, Serenari, Matteo, Serra, Margherita, Solli, Piergiorgio, Sorbi, Gioia, Taffurelli, Mario, Tanzanu, Marta, Tarsitano, Achille, Tesei, Marco, Vago, Gabriele, Violante, Tommaso, Zanotti, Simone, Aspide, Raffaele, Bertolini, Giacomo, Bortolotti, Carlo, Carretta, Alessandro, Caruso, Ambra, Conti, Alfredo, De Vita, Carla, Friso, Filippo, La Corte, Emanuele, Mazzatenta, Diego, Pirina, Alessandro, Rosetti, Vittoria, Sturiale, Carmelo, Vincenzi, Matteo, Zoli, Matteo, Castagnini, Francesco, Donati, Davide Maria, Frisoni, Tommaso, Lucchini, Stefano, Palmerini, Emanuela, Traina, Francesco, Baietti, Anna Maria, Berselli, Bruno, Bolognesi, Silvia, Fabbri, Erich, Farnia, Francesco, Maremonti, Pietro, Marganella, Concetta, Pasquini, Ernesto, Piserchia, Vito Antonio, Prucher, Gian Marco, Razzaboni, Alessandra, Ricci, Silvia, Sollini, Giacomo, Testoni, Caterina, Hilal, Mohammed Abu, Graaf, Nine, La Mendola, Roberta, Arrigoni, Giulia, Baiocchi, Gian Luca, Cagnazzi, Elena, D’Alessio, Rossella, Doglietto, Francesco, Ferrari, Federico, Fontanella, Marco, Igor, Batog, Molfino, Sarah, Odicino, Franco, Panciani, Pier Paolo, Saraceno, Giorgio, Sartori, Enrico, Zanin, Luca, Esposito, Giuseppe, Frongia, Federica, Pisanu, Adolfo, Podda, Mauro, Cillara, Nicola, Putzu, Alessandro Cannavera, Sechi, Raffaele, Abate, Emmanuele, Casati, Massimiliano, Laface, Letizia, Schiavo, Marcello, Marino, Fabio, Perrone, Fabrizio, Annicchiarico, Paolo, Cappellani, Alessandro, Cavallo, Matteo, Giaquinta, Alessia, Gioco, Rossella, Veroux, Massimiliano, Veroux, Pierfrancesco, Zanghì, Antonino, Cianci, Antonio, Giudice, Arturo Lo, Matarazzo, Maria Grazia, Russo, Giorgio Ivan, Sarpietro, Giuseppe, Scandura, Carmen Emanuela, Barca, Ida, Carnevali, Adriano, Carpino, Antonio, Cristofaro, Maria Giulia, De Paola, Gilda, Giannaccare, Giuseppe, Novembre, Daniela, Sammarco, Giuseppe, Scorcia, Vincenzo, Angeli Christy, Yu, D’Andrea, Marcello, Mongardi, Lorenzo, Tosatto, Luigino, Barone, Mirko, Mucilli, Felice, Muraglia, Angelo, Caserini, Ottavia, Giuliani, Domenico Benvenuto, Monti, Marco, Morello, Alessia, Segalini, Edoardo, Borghi, Felice, Cianflocca, Desiree, Daniele, Alberto, Donati, Danilo, Gelarda, Enrico, Giraudo, Giorgio, Giuffrida, Maria Carmela, Marano, Alessandra, Olearo, Elena, Ciarello, Vincenzo Pruiti, Puppo, Andrea, Testa, Valentina, Giacometti, Marco, Zonta, Sandro, Monti, Eleonora, Porta, Andrea, Sambucci, Daniele, Birindelli, Arianna, Carrara, Barbara, Compagnoni, Bruno, Del Giudice, Roberto, Dester, Sara Elisabetta, Lomiento, Daniele, Ruggiero, Silvia, Taglietti, Lucio, Viotti, Fabio, Lacavalla, Domenico, Occhionorelli, Savino, Rubbini, Michele, Bernabei, Massimiliano, Fabbri, Nicolò, Fazzin, Marta, Feo, Carlo V., Torchiaro, Marco, Costi, Renato, Virgilio, Edoardo, Arlia, Lorenzo, Barbato, Giuseppe, Bartolini, Ilenia, Bottari, Andrea, Bruno, Chiara, Bruscino, Alessandro, Checcucci, Carlotta, Cianchi, Fabio, Coratti, Francesco, De Vincenti, Rosita, Di Bella, Annamaria, Fambrini, Massimiliano, Fortuna, Laura, Gallo, Oreste, Gigliucci, Giacomo, Locatello, Luca Giovanni, Maltinti, Gherardo, Martellucci, Jacopo, Prosperi, Paolo, Ringressi, Maria Novella, Sorbi, Flavia, Staderini, Fabio, Taddei, Antonio, Anastasi, Alessandro, Canonico, Giuseppe, Chisci, Emiliano, Gabellini, Linda, Masciello, Fabrizio, Michelagnoli, Stefano, Nelli, Tommaso, Tirloni, Luca, Alemanno, Giovanni, Arminio, Armando, Beck, Renata, Bergamini, Carlo, Cotoia, Antonella, Lizzi, Vincenzo, Maccagnano, Giuseppe, Pesce, Vito, Sarni, Antonio Luciano, Tartaglia, Nicola, Vovola, Fernanda, Avanzolini, Andrea, Bocchino, Antonio, Bova, Raffaele, Cavaliere, Davide, D’Acapito, Fabrizio, Ercolani, 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Antonino Francesco, Mazzeo, Carmelo, Bertoglio, Camillo Leonardo, De Martini, Paolo, Ferrari, Giovanni, Giani, Alessandro, Lombardi, Pietro Maria, Mazzola, Michele, Baldari, Ludovica, Bissacco, Daniele, Boni, Luigi, Cassinotti, Elisa, Domanin, Maurizio, Pignataro, Lorenzo, Torretta, Sara, Trimarchi, Santi, Armellin, Daniele, Basato, Silvia, Bernardi, Laura, Bunino, Francesca, Capretti, Giovanni, Carrano, Francesco Maria, Castoro, Carlo, Colombo, Giovanni, Costantino, Andrea, De Lucia, Francesca, De Virgilio, Armando, Di Bari, Matteo, Ferreli, Fabio, Gaino, Francesca, Gramellini, Marco, La Raja, Carlotta, Malvezzi, Luca, Marano, Salvatore, Mercante, Giuseppe, Milana, Flavio, Nappo, Gennaro, Peros, Georgios, Pirola, Francesca, Rossi, Vanessa, Russo, Elena, Spriano, Giuseppe, Tamburello, Sara, Zerbi, Alessandro, Aiolfi, Alberto, Bona, Davide, Sozzi, Andrea, Adamoli, Laura, Ansarin, Mohssen, Bertolaccini, Luca, Cenciarelli, Sabine, Chu, Francesco, De Berardinis, Rita, Romario, Uberto 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Fusini, Federico, Gattolin, Andrea, Migliore, Marco, Rimonda, Roberto, Sasia, Diego, Travaglio, Elisabetta, Brunetti, Federica, Cereda, Marco, Ceresoli, Marco, Cigagna, Luca, Dell’Oro, Cristina, Fogliati, Alessandro, Fruscio, Robert, Grassi, Tommaso, Isabella, Maini Marzia, Nespoli, Luca Carlo, Oldani, Massimo, Ornaghi, Sara, Tamini, Nicolò, Antropoli, Carmine, Castaldi, Antonio, Palumbo, Alessio, Altieri, Gaia, Bracale, Umberto, Corcione, Francesco, De Luca, Marcello, De Palma, Giovanni Domenico, Di NUZZO, Maria Michela, Lionetti, Ruggero, Bue, Dalila Loredana Lo, Luglio, Gaetano, Pagano, Gianluca, Peltrini, Roberto, Pirozzi, Nello, Tropeano, Francesca Paola, Aversano, Alessia, Belli, Andrea, D’Amico, Maria, Delrio, Paolo, Izzo, Francesco, Patrone, Renato, Rega, Daniela, Maida, Pietro, Marra, Ester, Marte, Gianpaolo, Tufo, Andrea, Bianco, Francesco, Cappiello, Antonio, Gili, Simona, Incollingo, Paola, Novi, Alessandra, Bagaglini, Giulia, Iovino, Claudio, Tasselli, Francesco Menegon, 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Andreani, Lorenzo, Antonio, Darienzo, Aprile, Vittorio, Balestri, Riccardo, Benettini, Giacomo, Berrettini, Stefano, Bruschini, Luca, Chiarugi, Massimo, Coccolini, Federico, Colangeli, Simone, Cremonini, Camilla, Mencacci, Lodovica Cristofani, Dallan, Iacopo, De Santi, Silvia, Di Franco, Gregorio, Di Girolami, Lorena, Fiacchini, Giacomo, Furbetta, Niccolò, Korasidis, Stylianos, Lucchi, Marco, Morandi, Andrea, Morelli, Luca, Musetti, Serena, Neri, Carlo Maria, Palmeri, Matteo, Picariello, Miriana, Porcelli, Francesco, Puccini, Marco, Roffi, Nicolo, Statuti, Erica, Tartaglia, Dario, Tonelli, Alberto, Vianini, Matteo, Baronio, Gianluca, Montuori, Mauro, Pinotti, Enrico, Basso, Stefano Maria Massimiliano, Maffeis, Federica, Ubiali, Paolo, Aguzzoli, Lorenzo, Coiro, Saverio, Falco, Giuseppe, Mandato, Vincenzo Dario, Mastrofilippo, Valentina, Mele, Simone, Baldi, Caterina, Corbellini, Carlo, Sampietro, Gianluca Matteo, Dugo, Massimo, Garino, Mauro, Marafante, Chiara, Masciandaro, Antonio, 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Persiani, Roberto, Puccioni, Caterina, Ratto, Carlo, Rosa, Fausto, Saponaro, Gianmarco, Scardina, Lorenzo, Silvia, Tedesco, Tropeano, Giuseppe, Benevolo, Maria, Bugada, Daniele, Campo, Flaminia, Dona, Maria Gabriella, Manciocco, Valentina, Marchesi, Paolo, Mastroianni, Riccardo, Mazzola, Francesco, Moretto, Silvia, Pellini, Raul, Petruzzi, Gerardo, Pichi, Barbara, Simone, Giuseppe, Tuderti, Gabriele, Zocchi, Jacopo, Cosentino, Luigi Marino, Sagnotta, Andrea, Angelico, Roberta, Bellato, Vittoria, Campanelli, Michela, Franceschilli, Marzia, Grande, Michele, Lisi, Giorgio, Manzia, Tommaso Maria, Petagna, Lorenzo, Sensi, Bruno, Sica, Giuseppe, Siragusa, Leandro, Tisone, Giuseppe, Assenza, Marco, Binda, Barbara, Biondi, Massimo, Brachini, Gioia, Bruzzaniti, Placido, Casagrande, Mauro, Ciccarone, Flavia, Cicerchia, Pierfranco Maria, Cirillo, Bruno, Crocetti, Daniele, D’Ambrosio, Giancarlo, D’Andrea, Vito, De Felice, Francesca, De Toma, Giorgio, Rocca, Carlo Della, Duranti, Giulia, Familiari, Pietro, Fiori, Enrico, Fonsi, Giovanni Battista, Frati, Alessandro, La Rocca, Stefania, La Torre, Filippo, Lapolla, Pierfrancesco, Marruzzo, Giovanni, Meneghini, Simona, Mingoli, Andrea, Picchetto, Andrea, Polimeni, Antonella, Ribuffo, Diego, Salvati, Maurizio, Santoro, Antonio, Sapienza, Paolo, Simonelli, Luigi, Valentini, Valentino, Zambon, Martina, Zancana, Giuseppa, Zuppi, Emma, D’Annunzio, Simone, De Nunzio, Cosimo, Fiorelli, Silvia, Ibrahim, Mohsen, Loffredo, Chiara, Massullo, Domenico, Menna, Cecilia, Monica, Rocco, Pelli, Massimiliano, Rendina, Erino Angelo, Teodonio, Leonardo, Tubaro, Andrea, Argenio, Giulio, Accarino, Giulio, Giancarlo, Accarino, Giordano, Antonio Nicola, Cardinali, Luca, Sebastiani, Elisa, Travaglini, Grazia, Andreatta, Erika, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele, Bonavina, Luigi, Froiio, Caterina, Lovece, Andrea, Copelli, Chiara, Manfuso, Alfonso, Di Maio, Pasquale, Giudice, Marco, Iocca, Oreste, Cennamo, Rosario, Cornali, Tommaso, Di Marzo, Francesco, Altana, Cristian, Bussu, Francesco, Capobianco, Giampiero, Carta, Anna Giacomina, Ciccarello, Sandro, Cossu, Maria Laura, Cottu, Pietrina, De Riu, Giacomo, Dessole, Salvatore, Dessole, Francesco, Dettori, Salvatora, Doria, Carlo, Fancellu, Alessandro, Feo, Claudio F, Ginesu, Giorgio Carlo, Giuliani, Giuliana, Iannuccelli, Marco Giuseppe, Madonia, Massimo, Mancino, Roberto, Massarelli, Olindo, Meloni, Gianfranco, Milia, Fabio, Mulliri, Andrea, Perra, Teresa, Petrillo, Marco, Piras, Antonio, Piredda, Franco, Pisanu, Francesco, Porcu, Alberto, Rizzo, Davide, Sanna, Angelino, Scanu, Antonio Mario, Scognamillo, Fabrizio, Soma, Damiano, Tanca, Anna Rita, Tedde, Alessandro, Tedde, Matteo, Vaira, Luigi Angelo, Pazzi, Andrea Bartalini Cinughi, Samorani, Osvaldo Carpineto, Fusario, Daniele, Marano, Luigi, Oldrà, Gaia, Pesce, Anna Lisa, Piccioni, Stefania Angela, Resca, Luca, Ricchiuti, Vincenzo, Roviello, Franco, Savelli, Vinno, Abrate, Alberto, Bordoni, Pierpaolo, Bosio, Lorenzo, 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Rinaldi, Mauro, Ruffini, Enrico, Salizzoni, Stefano, Bardelli, Laura, Berselli, Mattia, Borroni, Giacomo, Cocozza, Eugenio, Desio, Matteo, Elisa, Bottazzoli, Ietto, Giuseppe, Iori, Valentina, Iovino, Domenico, Livraghi, Lorenzo, Marchionini, Valentina, Megna, Stefano, Nahal, Emma Amal, Palumbo, Mara, Quintodei, Valeria, Zullo, Alessandra, D’Alimonte, Lucrezia, Pirozzolo, Giovanni, Vignotto, Chiara, Campagnaro, Tommaso, Caravati, Andrea, Conci, Simone, De Cristofaro, Carlotta, Gecchele, Gabriele, Giuliani, Tommaso, Graziosi, Jacopo, Guglielmi, Alfredo, Paiella, Salvatore, Pedrazzani, Corrado, Pollini, Tommaso, Rattizzato, Simone, Ruzzenente, Andrea, Salvia, Roberto, Turri, Giulia, Bacchion, Matilde, Butturini, Giovanni, Casaril, Andrea, Giardino, Alessandro, Impellizzeri, Harmony, Inama, Marco, Isabella, Frigerio, Moretto, Gianluigi, De Zuanni, Marco, Deiana, Enrica, Guglielmo, Mario, Broglia, Alessandro, Casarini, Claudia, Zingaretti, Caterina Costanza, Bonaldi, Marta, Cesana, Giovanni, Mastriale, Francesco, Olmi, Stefano, Fukami, Matteo Uccelli Yasuyuki, Saito, Takuya, Sano, Tsuyoshi, Hirai, Naoki, Hirota, Kazuyoshi, Kushikata, Tetsuya, Oyama, Tasuku, Saito, Junichi, Ishibashi, Katsuhiko, Kamiyama, Mizue, Son, Kyongsuk, Tarao, Kentaroh, Yamada, Takayuki, Shiga, Toshiya, Aze, Chisaki, Deguchi, Yoshihiko, Hasegawa, Hirotoshi, Hoshino, Tatsuki, Innami, Yasushi, Inoue, Hiroyuki, Ito, Shingo, Nomura, Takeshi, Ogihara, Tomomi, Okada, Reina, Ouchi, Takashi, Sekiya, Yuri, Tachibana, Keikoku, Takano, Emi, Yamamoto, Masae, Matsuda, Shuko, Matsuki, Yuka, Shigemi, Kenji, Hiraki, Teruyuki, Inoue, Yui, Jotaki, Shosaburo, Abe, Tatsuro, Eto, Masatoshi, Inokuchi, Junichi, Kashiwagi, Eiji, Kinoshita, Fumio, Kobayashi, Satoshi, Lee, Ken, Matsumoto, Takashi, Monji, Keisuke, Naganuma, Hidekazu, Shiota, Masaki, Takeuchi, Ario, Obara, Shinju, Takatsuki, Saori, Tanaka, Saori, Iida, Koji, Kagawa, Kota, Neshige, Shuichiro, Chaki, Tomohiro, Hirata, Naoyuki, Kazuma, Satoshi, Kimizuka, Motonobu, Kumita, Sho, Nishihara, Noriaki, Satoshi, Sato, Sawada, Atsushi, Tachibana, Shunsuke, Yamakage, Michiaki, Nakamura, Yuta, Sato, Kozo, Irie, Tomoya, Irisawa, Tomoko, Kanemaru, Eiki, Koga, Yuko, Chiba, Yoshihiko, Makino, Jun, Ohama, Shinnosuke, Okada, Shinichiro, Teruaki, Kano, Kida, Tatsuya, Takei, Tomohide, Hanazaki, Kazuhiro, Kitagawa, Hiroyuki, Namikawa, Tsutomu, Mizota, Toshiyuki, Takeda, Chikashi, Yagi, Shintaro, Imai, Hiroshi, Ishitobi, Makoto, Kato, Manabu, Nishikawa, Kouhei, Sasaki, Takeshi, Yonekura, Hiroshi, Kanaya, Akihiro, Irimada, Daisuke, Ishikawa, Haruka, Kaiho, Yu, Ida, Mitsuru, Kawaguchi, Masahiko, Kawamura, Kenji, Ogawa, Munehiro, Okada, Hiroshi, Endo, Shunji, Fujiwara, Yoshinori, Higashida, Masaharu, Kubota, Hisako, Okada, Toshimasa, Tanaka, Hironori, Ueno, Tomio, Yoshimatsu, Kazuhiko, Kikukawa, Motohiro, Kuriyama, Akira, Matsushime, Susumu, Hidehiko, Hishikawa, Hino, Haruaki, Hisamatsu, Yoji, Kamiya, Akio, Kinoshita, Hidefumi, Kita, Masato, Kobayashi, Toshinori, Michiura, Taku, Miki, Hirokazu, Murakawa, Tomohiro, Okada, Hidetaka, Saito, Tomohito, Saito, Ryoichi, Sugi, Motohiko, Sumi, Genichiro, Yamaki, So, Yamamoto, Tomohisa, Yoshida, Aya, Kambara, Tatsuya, Kanematsu, Sayaka, Satoshi, Okazaki, Hijikawa, Takeshi, Kitade, Hiroaki, Yanagida, Hidesuke, Fujita, Tomoyuki, Fukushima, Satsuki, Tadokoro, Naoki, Furukawa, Taku, Iizuka, Yusuke, Otsuka, Yuji, Sanui, Masamitsu, Sawada, Ikumi, Iwahashi, Hideki, Miyamoto, Morikazu, Takano, Masashi, Mieda, Tsutomu, Ando, Chihiro, Isada, Tetsuro, Ishizaki, Taku, Amer, Qaed Bani, Ishida, Sachi, Kobayashi, Yasuma, Kuratani, Norifumi, Sakurai, Tomoe, Takada, Misa, Iba, Yutaka, Tsukagoshi, Junji, Yamada, Akira, Amano, Yuki, Fumoto, Kentaro, Noro, Shusaku, Fujimoto, Ayataka, Tomoto, Kyoichi, Okamura, Yukiyasu, Sugiura, Teiichi, Uesaka, Katshuhiko, Takemura, Natsuki, Kuroda, Kento, Hayashi, Megumi, Kaneko, Satoi, Kawagoe, Izumi, Kochiyama, Tsukasa, Yamaguchi, Ai, Abe, Nobutsugu, Ando, Tadao, Chinzei, Mieko, Hirano, Kouichi, Kobayashi, Yoichi, Matsuki, Ryota, Matsumoto, Hironori, Motoyasu, Akira, Nakazawa, Harumasa, Noguchi, Hikari, Okamura, Kaio, Ono, Motoaki, Seki, Hiroyuki, Sunami, Eiji, Tajima, Atsushi, Tanigaki, Shinji, Uzawa, Kohji, Watanabe, Hidenobu, Furuhata, Yukari, Toyama, Satoshi, Uchida, Tokujiro, Enomoto, Yutaka, Furukawa, Yuri, Hasumi, Yoko, Hirota, Jinso, Iida, Katsuyuki, Ikeda, Shingo, Ikeda, Tatsuhiko, Kawamata, Natsuko, Kawasaki, Yosuke, Koizumi, Minako, Kono, Yoshiharu, Kuzuhara, Shigeki, Maeda, Junichi, Moriyama, Mai, Nagamoto, Shoichi, Nakanishi, Rinako, Noda, Michio, Seichi, Atsushi, Takahashi, Shintaro, Takashi, Kobayashi, Takeda, Misuzu, Tanakura, Kenta, Terajima, Katsuyuki, Tsuji, Munechika, Ueshima, Chiharu, Yamamoto, Naoya, Yamamoto, Mari, Yokota, Toshiya, Yoshioka, Yuki, Yuri, Sakoh, Iwata, Shintaro, Kawai, Akira, Osaki, Shuhei, Ishikawa, Masashi, Iwasaki, Masae, Morita, Tomonori, Hirooka, Reina, Nakata, Yoshinori, Sawamura, Shigehito, Ishida, Yusuke, Kawachi, Aya, Kobayashi, Takayuki, Nagashima, Fumiaki, Suzuki, Naoki, Ando, Kohei, Miyazawa, Noriko, Tanaka, Yukio, Abuissa, Khatab, Aljabali, Alaa, Almasri, Amal, Alrabadi, Mera, Alshara, Rana, Alzghoul, Yasmeen, Alzughoul, Ahmed, Freihat, Ali, Jeitan, Emran, Owais, Qais, Smadi, Aseel, Abukhadra, Mahmoud, Abunawas, Huthifa, Al‐azzam, Abdallah Ahmed Mezel, Aladaileh, Ammar, Albadawi, Ismail, Alhawatmeh, Mohammad, Alkhaza’Leh, Mohannad Yaser, Alneimat, Roaa Salem Jwaid, Alwahedy, Saba, Alwardat, Abdel Rahman Mohannad Ahmad, Dhoon, Slsabela, El‐qawaqzeh, Khaled, Hrerat, Tarteel, Jaradat, Enas, Mubaydeen, Teeba, Sarayrah, Husam, Tarawneh, Mohammad Abdel Elah A., Karasneh, Mohammad Yousef, Zurgan, Amany, Alassaf, Mohammad, Alzraikat, Sayel H., Amarin, Justin Z., Hijjawi, Ahmed, Suradi, Haya H., Zaghlol, Louay Y., Abdalah, Ahmad, Abdallah, Ghaida, Tarieh, Ammar Abu, Abu‐libdeh, Tareq, Abualteen, Faisal, Al Abdallah, Murad, Al Bdour, Zakaria, Al Dahabrh, Seif, Al‐kasaji, Farah, Ali, Zaid Al‐sheikh, Al‐thaher, Mohammad, Alnajjar, Tareq, Alqedrh, Mohannad, Alsaleh, Mohammad, Alzaatreh, Mohammad, Amayreh, Ghandi, Ayasra, Yazeed, Eid, Ahmad, Ghayada, Ibrahim, Moh’d Ahmed Hasanein, Khaled, Hassouneh, Anas, Hijazeen, Raid, Hmeidan, Majedah, Khaled, Ahmed, Khasawneh, Barihan, Kifayeh, Omar, Lafi, Yasser, Seba, Jasem, Semrin, Qusai, Sma, Fda, Theab, Mohammad, Tumeh, Haitham, Zaid, Muna Aba, Abazeed, Alaa, Abbad, Bader, Abbadi, Osaid, Abu‐ishkerih, Nizar, Al‐osta, Malk, Al‐zyadat, Reham, Alawneh, Bashar Omar Falah, Alhattab, Majd, Alkurdieh, Mohd Mujahed, Awwad, Ziad, Hammouri, Mohammad, Hussein, Hamzeh, Khader, Sereen, Khalil, Mariam, Mansour, Omar, Othman, Ahmad, Qandeel, Haitham, Saleem, Mohammad, Souri, Fouad, Tahboub, Ahmad, Tayyem, Raed, Abdallah, Munir, Abdel‐hafez, Ibrahim, Obead, Hamza Abu, Abudari, Hadeel, Abuhamour, Ehab, Abusadah, Samer, Al‐azzeh, Nimer, Al‐adwan, Sofian, Al‐darabah, Ali, Al‐qannas, Mohammad, Albaba, Basil, Alradawneh, Qutaiba, Amaireh, Mohammad, Ashour, Subhi, Chabaan, Reem, Eskander, Ammar, Fawzi, Ahmad, Haij, Manal, Hamad, Hisham, Hamdan, Haya, Hamss, Ahmed, Hassouneh, Esraa, Hyasat, Ayah, Ibrahim, Zainab, Jamaliah, Saja, Khalil, Mohammed, Massad, Anas, Mohamed, Ishak, Qandeel, Mahmoud, Qasrawi, Dalia, Raggad, Mahmoud, Rifai, Ebaa, Semreen, Nedal, Shehada, Reham, Shorman, Marwan, Al‐shibi, Abdallah, Alsa’Afin, Shatha, Bani‐hani, Morad, Nimer, Bahaa, Nofal, Sandra, Qaraqe, Layth, Salameh, Mohammed, Saleh, Ma’Moun, Sanjuq, Ghaidaa, Sharabi, Alaa, Sweiti, Alaa, Yaghmour, Jamal, Zaza, Sabri, Alhindi, Rahaf, Baninasr, Eman, Al‐masri, Mahmoud, Al‐najjar, Hani, Alawneh, Fade, Al‐latayfeh, Motasem, Al‐shudifat, Abdel‐ellah, Ahmad, Abd Almonem Shaikh, Abdeljalil, Abdelkarim, Abdelrahman, Haneen, Abdulmalek, Abdulmalek, Abedalqader, Lina, Abed, Laith Abu, Al Smadi, Omar, Alarood, Salameh, Allouzi, Mohammad, Almansour, Maha, Almi’Ani, Sari, Alsaiad, Abdulhakim, Alshaikh, Khaled, Androus, Farah, Awbakh, Mirna, Azzam, Belal, Yasin, Hammam Bany, Daoud, Maher, Dawod, Lujain, Dawod, Omar, Elmusa, Reem, Fadli, Saba, Hammad, Farah, Hunaiti, Majd, Muhtaseb, Mahmoud, Owaimer, Rawan, Qulaghassi, Zaki, Romman, Saleh, Saket, Rawand, Sharawi, Said, Tawalbeh, Alaa, Al‐howthi, Mohammed, Ababneh, Laila, Ababneh, Roba, Za’Nouneh, Faris Jamal Abu, Al DHOUN, Sajedah, Al Khassawneh, Ahmad, Al Sharie, Ahmed, Al Shraideh, Ayah Ahmad, Al‐dabaa, Tawfik, Al‐jarrah, Salsabeel, Al‐jarrah, Hothaifa, Al‐othman, Hadeel, Alaradi, Zuhair, Alshannaq, Qutaiba, Alsulaiman, Rima, Alzaqh, Motasem, Alzu’Bi, Yazan, Audat, Ziad, Bahhour, Mohammad, Bdour, Saja, Khatatbeh, Roa, Marji, Fares, Mazahreh, Tagleb, Nail, Dina, Nuseir, Amjad, Rabab’Ah, Asmaa, Sawadi, Taher, Zidan, Ghina, Muhfouz, Dima Abu, Nael, Abdullah, Qasim, Ahmad, Al‐jarrah, Amar, Rawagah, Faisal, Abu Ismail, Dima Y, Al‐dolat, Wedad, Alzoubi, Mai, Alzoubi, Malak, Alzu’Bi, Mu’Taz, Asha, Ruba, Guboug, Ali, Hussein, Hasan, Rawashdeh, Shireen, Sanwar, Mohammad, Ababneh, Adnan, Abu‐eisheh, Basil, Alhami, Haneen Ahmad, Al Dwairi, Saif Aldeen, Al Shurman, Hana’, Al Yahya, Zakaria, Al‐atiyah, Hussam, Al‐balas, Hasan, Aljaiuossi, Anas, Alqawasmi, Shatha, Alqudah, Sadeel, Alshourman, Mahmoud, Hamad, Abdulsalam Bani, Issa, Anas Bany, Ennab, Raed, Hamdoni, Sara, Hijazi, Zaid, Khafaja, Ali, Mraiyan, Mohamed, Obeidat, Riyad, Olaywah, Dina, Qudah, Mohamad, Talal, Mhamdd, Aidarov, Askar, Sarmenova, Aisulu, Kodasbaev, Almat, Sakhov, Orazbek, Tanabayeva, Shynar, Amrayev, Sultan, Dzhumabekov, Berik, Malgazhdarov, Maulen, Tezekbaev, Kanat, Kukubassov, Yerlan, Satanova, Alima, Mwachiro, Michael, Parker, Robert, Simel, Ian, Mohammedali, Shamshuddin, Mwaria, Claude, Obure, Ralph, Shah, Sayed Shah Nur Hussein, Hirani, Chetan, Kibunyi, Muthoni, Mailu, Claire, Mwangi, Victor, Ogenya, Roy, Osea, Lydia, Cheruiyot, Davies, Hirsi, Omar, Muiru, Carolyne, Wanjara, Samuel, Kim, Chang Woo, Lee, Suk Hwan, Almulla, Ahmad, Dashti, Mustafa, Elghany, Omar, Sultan, Abdullah, Al‐mahmeed, Husain, Alabbad, Jasim, Albader, Ibtisam, Aldalal, Shuaib, Baba, Mahdi, Abdulsalam, Fareed, Alhajri, Naser, Alwael, Athari, Ayele, Brook, Marie, Hatem, Zaitoun, Ahmed, Alali, Ahmad M., Alkhamis, Ahmed, Alozairi, Ous, Almazeedi, Sulaiman, Alsabah, Salman, Abdelkarim, Mostafa, Al Rashed, Asmaa, Al Subaie, Saud, Al‐shaiji, Tariq, Al‐terki, Abdullatif, Alhunaidi, Omar, Aljewaied, Ali, Alzamel, Khaled, Farag, Ahmed, Hayati, Hussein, Termos, Salah, Wood, Sarah, Al‐gilani, Maha, Al‐sihan, Mutlaq, Alotaibi, Haifa, Lobovs, Dmitrijs, Pcolkins, Andrejs, Sivins, Armands, Apse, Ingus Arnolds, Berga, Annija Evelīna, Ivanova, Anna, Demicevs, Jevgenijs, Ivanovs, Igors, Kaminskis, Aleksejs, Opincans, Janis, Pāvulāns, Jānis, Rudzāts, Agris, Udre, Anna, Dbouk, Samer, Farfour, Imadeddine, Rakka, Mohamad, Antonios, Ingrid, El Hage, Joe, Hage, Stephanie, Haiby, Lea, Kahi, Hiba, Lichaa, Anthony, Moussa, Rita Milan, Salameh, Michel, Sarkis, Riad, Albaini, Obey, Haykal, Tony, Safadi, Bassem, Abou‐abbass, Hussein, Al Makari, Reem, Al Zein, Zeina, Baidoun, Mariam, Itani, Rania, Owiedat, Mustafa, Abdel Sater, Ali H., Akl, Michel, Badran, Nour, El Mustapha, Sara, Fatouh, Fathallah, Ghoussoub, Youssef, Saad, Nader, Serhan, Fatima, Souleiman, Bassem, Alame, Walid, Ghiya, Peter, Ibrahim, Firas, Abdallah, Rasha, Kassab, Mohamad B., Karout, Samar, Aya Abdul, Al, Chaaban, Hilal, Fakih, Ghinwa, Haj‐ibrahim, Huzifa, Awad, Rabih, El Assaad, Hadi, Alfeqeeh, Ahmed, Muftah, Hosam, Abdulrahman, Taha, Ahseen, Naeimah, Abunaaja, Hayat Omar, Abdulmalik, Abdulmuez, Al Gasi, Abd El Jawad, Alsaeiti, Sara, Elkhafeefi, Fatimah, Elrefai, Nasre, Ahmad, Rofida, Alhouni, Tarek, Alkarky, Safya, Alkeelani, Hana, Alkuwafi, Rauoof, Benhariz, Rema, Bettamer, Nagat, Busarira, Musa, Bushaala, Hassan, Diryaq, Tariq, Elbargathe, Osama, Eldarat, Tarik, Elfadli, Mustafa, Elfitori, Jamael, Elmahgoub, Asma, Elsahti, Reem, Hassan, Yosef, Hussain, Fathi, Mirsal, Taha, Mohammed, Marwa, Saad, Ebtesam, Hadad, Haifaa Il, Mosabha, Mostafa, Alhaje, Awatif, Haron, Aaya, Alsuwiyah, Suhir, Hamed, Mona, Khel, Samer, Omar, Sana, Yousef, Rowaida, Abdelmalik, Abubaker, Abosnaina, Yahya, Abuhlaiga, Ma’Aly, Abushahma, Ahmed Omar, Aldelensi Alzubi, Alhosen Saleh M, Aljanfi, Asma, Alnehum, Mohamed Alnaser, Alzedam, Ahmad, Delhen, Malik, Maderi, Galia, Matoug, Faisel, Mohammed, Burooj, Sawalem, Mohamed, Jahan, Alhadi, Jahan, Abdussalam, Alazabi, Basma, Alezabi, Bahauldin, Alazabi, Mona Masaud Amro, Egdeer, Amin Salem Ahmed, Sefi, Fatma, Kamoka, Elhusain, Salamah, Abdulrauf, Abdalhadi, Alya, Abdeewi, Saedah, Alhadad, Marwah, Awrayit, Ahmed, Eshnaf, Mabroka, Yahmad, Mohammad, Abudher, Abdulhafid, Elamin, Faisl, Abojeila, Farah, Aliwa, Mohamed, Jouira, Rayet Al Islam Ben, Shagour, Sana, Altobal, Ahmed, Aljuroushi, Omar, Almadani, Hadeel, Attia, Hajer, Eljali, Amal Sharif, Emran, Ayyah, Omar, Mabruka, Salim, Radhwan, Samer, Ashraf, Abulshuwashi, Nayrouz Abdullah, Ben Khalifa, Emadeddin T M, Benabdalla, Hdaya Abdalla S, Elnageh, Hatem, Hammad, Ali, Abdullah, Duha Milad, Abusalem, Marwa, Esmael, Esraa Ben, Benmasoud, Fatma, Debri, Laila, Elmokhtar, Randa, Sheta, Manal Ezeddin Kamel, Elhabashi, Bushra Sayeh Mohamed, Younis, Balkees, Elmabrouk, Amna, Momen, Ahmed, Alzoubi, Abdalrahem Essied Alzubi, Ayad, Kusay, Hasan, Ameerah Mahdi Abraheem, Musrati, Fawzie, Abusannoga, Malek, Malek, Ans, Ajaj, Hatem, Abdulwahed, Eman, Aboubeirah, Mohammed, Alqurpaa, Aya, Alshareea, Entisar, Aribi, Sarra, Aribi, Tomather, Biala, Marwa, Ghamgh, Reem, Issa, Mohannned, Lamari, Amani Hamid, Mufth, Mohammed, Abboud, Omar Sudig, Hallalah, Muad Fathi Khalleefah Abu, Abumahara, Saleh, Aburima, Sarah, Adrees, Mohammed, Ahtash, Abdurahman, Al Shukri, Asmaa, Alameen, Hind, Alarabi, Rehab, Alarabi, Alarabi, Alelwany, Aisha, Alesmail, Abdulkarim, Algadi, Noran, Almaqrahi, Khuloud, Alosta, Hadel, Alsharedi, Mohamed, Bashir, Rasha, Ghrema, Mahmoud Ben, Nour, Sari Bin, Elbarouni, Sofian, Elhadi, Ahmed, Elkhadar, Abdulmohimen A, Elkouba, Esraa, Elmsherghi, Nabiha, Gammoudi, Abdulmohimen, Ghariba, Abdulraouf, Gjam, Fatima Zayed, Haidar, Arwa, Helal, Hala, Huwaysh, Mohammed, Alhadheeri, Ahmed Khalid, Kriem, Eslam, Osman, Halim, Ossman, Mohamed Ali, Shilfeet, Marwah, Turshani, Laila, Albishty, Nouran, Alhadi, Abdulmueti, Ali, Salem, Altoumi, Manal Ahmed, Bahroun, Sumayyah Ghayth, Younes, Eman, Atarabulsi, Hana, Elshaibi, Mohamed, Othman, Abdullmujeeb, Hasan, Hayat Ben, Hasan, Najat Shaban Ben, Hasan, Rabab Shaban Ben, Barauskas, Vidmantas, Dainius, Edvinas, Dambrauskas, Zilvinas, Dauksa, Albertas, Dekeryte, Inga, Gudaityte, Rita, Jasaitis, Kristijonas, Koženiauskaitė, Akvilė, Krasauskas, Virgilijus, Lukosiute‐urboniene, Ausra, Maleckas, Almantas, Riauka, Romualdas, Šlenfuktas, Vygintas, Svagzdys, Saulius, Urbonas, Kestutis, Vanagas, Tomas, Venclauskas, Linas, Venskutonis, Donatas, Zilinskas, Justas, Ambrazevicius, Marijus, Syminas, Vilius, Aliosin, Oleg, Cizauskaite, Agne, Eismontas, Vitalijus, Jurgaitis, Jonas, Mikutaitis, Vytenis, 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Ghauth, Sakina, Hung, Weipin, Jamaris, Suniza, Koh, Peng Soon, Krishnasamy, Sivakumar, Lee, Yeong Sing, Liew, Yew Toong, Lim, Jeffery Zk, Lim, Raymond Chung Siang, Lim, Hiong Chin, Pauzi, Siti Farhan Moh, Nah, Shireen Anne, Nair, Ashvin Krishna, Doris Sin Wen, Ng, Yong, Yuki Julius Ng We, Ramayah, Kamarajan, Saaid, Rahmah, Sanmugam, Anand, See, Mee Hoong, Seevalingam, Kanesh Kumaran, Sethi, Neha, Singaravel, Srihari, Zaidi, Syeda Nureena Syed Jafer Hussain, Tang, Chu Yik, Teoh, Li Ying, Wong, Kian Boon, Xavier, Ruben, Yahaya, Ahmad Shuib, Norhafiza, Ab, Rahman, Null, Islah Munjih, Ab, Rashid, Null, Aziz, Mohd Fahmi Abd, Rahman, Mohd Norhisham Azmi Abdul, Amjad, Nasser Muhammad, Alhadi, Shahidah Che, Elagili, Faisal, Kamarulzaman, Mohd Nazli, Nor, Azmi Md, Othman, Ahmad Faidzal, Sainal, Mohd Yusof, Sarif, Mat Salleh, Chua, Richelle, Ibrahim, Aini Fahriza, Ahmad, Abdul Rauf Bin, Lau, Yii Ling, Liew, Ka Yee, Palayan, Kandasami, Wong, Hui Yu, Zakaria, Jasiah, Aziz, Nor Azimah Abd, Rahim, Norazila Abdul, Rahman, Noorneza Abdul, Abdullah, Bahiyah, Sikkandar, Mohamed Faizal Bin, Firman, Fatin, Hazleigh, Nik Mohd, Kamarudin, Intan Kartika, Khalid, Shahril, Miswan, Mohd Fairudz Mohd, Zahid, Akmal Zulayla Mohd, Mustafa, Norasyikin, Obaid, Kadhim, Yahaya, Mohd Yusoff Bin Yahaya, Yusoff, Ahmad Ramzi, Andrejevic, Predrag, Myatt, Jeremy Borg, Brincat, Svetlana, Caruana, Clifford, Chircop, Kurt Lee, Chircop, Francesca, Chircop, Daniel Mario, Cini, Charles, Czok, Viktoria, Farrugia, Melanie, Grima, Gabriella, Almukhariq, Fatimah MJ Hassan, Muscat, Esther, Pisani, Darryl, Roshan, Mohsin Hassan Khan, Schembri, Nicholas, Shoukry, Mohamed, Spiteri, Neville, Tanti, Gilbert, Hasan, Ziad Aboharp, Soto, Alberto Bazan, Rubén, Cedillo Rodrìguez Jonathan, Zamudio, Gustavo Esteban Lugo, Gómez, David Gerardo Miranda, Meave, José Alfredo Pérez, Victor Pinto Angulo, Null, Aguilar, Antonio Rojas, Duran, Erik Efrain Sosa, Perez, Alejandro Vàzquez, Arroyo, Diego, Corona‐cruz, Jose, Martinez‐said, Hector, Medina‐franco, Heriberto, Mendez, Manuel, Suárez Ma, Teresa Moreno Y, Díaz, Dolores Orta, León Vázquez, Martha Patricia Pérez, Carvajal, Angélica Azucena Soto, Hernández, Fidel Soto, Stenner, Juan Ignacio, López, Adriana Valenzuela, Hernandez, Mauricio Rene, Romero, Rey Jesus, Hernandez, Aldo Bernal, Cortes‐flores, Ana Olivia, Valle, Carlos Jose Zuloaga Fernandez, Tinajero, Carlos Andres Colunga, Orozco‐perez, Jaime, Balboa, Laura Gabriela Peña, Yanowsky‐reyes, Guillermo, Torres, Víctor Hugo Alcalá, Camacho, Francisco José Barbosa, Perez, Irma Valeria Brancaccio, Calderon‐llamas, Miguel Angel, Gomez, Aldo Camacho, Cortes‐torres, Edgar‐joaquin, Cueva‐martinez, Esteban, Anguiano, Oscar Durán, Estrada, Isaac Esparza, Fierro‐rizo, Roberto, Becerril, Paola Flores, Orozco, Clotilde Fuentes, Castillo, Miguel García, Ojeda, Alejandro Gonzalez, Rubio, Ana Sofia Gonzalez, Rojas, Erick Alonso González‐García, Govea‐camacho, Luis Humberto, Barba, Jose Aldo Guzman, Peña, Juan Carlos Ibarrola, Martínez, César íñiguez, Llamas‐macias, Francisco Javier, Galaviz, Ruben Eduardo Morán, Nuño‐escobar, Cesar, Olvera‐flores, Oscar‐everardo, Osuna‐rubio, Jaqueline, Pérez‐navarro, Jose Victor, Prieto‐aldape, Rodrigo, Gonzalez, Luis Ricardo Ramirez, Sánchez, Marco Vinicio Ramírez, Reyes, Emilio, Romero‐limón, Olaya Moramay, Ruiz‐velasco, Carlos Beas, Martínez, José Antonio Sánchez, Sanchez‐villaseñor, Guillermo, Sedano‐portillo, Ismael, Gonzalez, Gabriela Ambriz, Moreno, Pedro Berrones Moreno Berrones, Alvarado, Ana Beatriz Calderon, Jesús Cárdenas Barón, José, Hernández, Araceli, Frutos, Francisco Javier León, Hernandez, Edgard Efren Lozada, Valencia, Eduardo Morales, Pérez, Karla Daniela, Bolanos‐morales, Francina, Herrera‐zamora, Julio, Santillan‐doherty, Patricio, Zavala, David Omar Arriaga, Campos, Salvador Francisco Campos, Carmona, Lizette, Nava, Antonio Galindo, Santos, Blanca, Cisneros, Juan Roberto Torres, Bozada‐gutiérrez, Katya, Herrera, Jose Jesus, Portillo, Mucio Moreno, López, Francisco Pérez, Trejo‐avila, Mario, Salazar, Carlos Valenzuela, Alvarez, Maria Regina, Cordera, Fernando, Rosa Abaroa, Marco Antonio, Gómez‐pedraza, Antonio, Hernandez, Roberto, Maffuz‐aziz, Antonio, Posada, José Antonio, Vidal, Carlos Robles, Beristain‐hernandez, Jose‐luis, Sada, Blas Eduardo Quintero, Heredia, Nicolás Uxmal Soruco, Anaya, Ernesto, Arceo‐olaiz, Ricardo, Sougarret, Bernardo Gutiérrez, Flores, Sonia Lopez, Ochoa Carrillo, Francisco J., Uribe, Raymundo Alfredo Pérez, Silva, Ludwigvan Adriano Bustamante, Lupián‐angulo, Arianne I, Martínez, Christian Enrique Soulé, García, Francisco César Becerra, Casillas, Ernesto Javier Guerrero, Uribe, Edgar, Arias, Nereida Esparza, Hernández‐nava, J. Mindy, Isla‐ortiz, David, Melchor‐ruan, Javier, Bañuelos, Esmeralda Romero, Salcedo‐hernández, Rosa, Vilar‐compte, Diana, Peniche, Paola Zinser, Aguilar Frasco, Jorge L., Alfaro‐goldaracena, Alejandro, Buerba, Gabriela Alejandra, Castro, Emma, Chan, Carlos, Cortes, Ruben, Dominguez‐rosado, Ismael, Lechuga, Daniel Garay, Herrera, Miguel, Hinojosa, Carlos, Lopez‐pena, Gabriel, Martos, Edgar, Mercado, Miguel ángel, Velázquez, Paulina Moctezuma, Moguel, Roberto, Oropeza, Mariano, Portugal, Emmanuel Peña Gómez, Posadas‐trujillo, Oscar Emmanuel, Salgado‐nesme, Noel, Jasso, Oscar Santes, Sarre, Catherine, Skewes, Karla Yareli Hernandez, Jimenez, Cristian, Licona‐meníndez, Roque Delfino, Montiel, Guillermo, Navarrete‐peón, Alberto, Ortega, Shannat, Lechuga, Fernanda Romero, Roque, Oscar, Sevilla, Fernando, González‐lópez, Rogelio, Núñez‐gonzález, Roberto ángel, Ortega‐jiménez, José Antonio, Alvarado, Antonio, Orendain, Alfonso Alvarez Manilla, Pesquera, José Alberto Atristain, Frutos, Diego, Garcia, Felipe, León, Juan Antonio González, Guzman, Marlin, Herappe, Dorihela, Miranda, Jesús Giovanni Inzunza, Botello, Miguel Angel Jimenez, Lerma, Ricardo, Pedraza, Fabián Hilario Mendoza, Castillo, Monica Noguez, Resendiz, Jose Anatolio, García, Oscar Alejandro Sánchez, Rios, Laura Elena Fernandez, Frigerio, Pamela, Garcia, Iset, Frías, Gloria Isela Mendoza, Moreno, Emmanuel, Quiroga, Raquel, Mendoza, Alejandra Anzures, Hinojosa, Arantza Govela, Izaguirre, Aldo, Miguelena, Luis Hdez, Vazquez, Jose Manuel Luna, Rodriguez, Indalecio Barcelata, Mange, Raul Ramos, Utrera, Carlos Reyes, Saenz, David Zarate, Gonzalez, Miguel Angel Zavala, González, Francisco Andrade, Cortes, Ludivina, Roman, David, Sanchez, Aaron, Gurghiș, Radu, Rojnoveanu, Gheorghe, Vozian, Marin, Caraja, Petru, Croitor, Gheorghe, Mosneaga, Roman, Erdene, Sarnai, Ganbold, Lundeg, Orgoi, Sergelen, Orsoo, Soyombo, Sainbayar, Altanchimeg, Sandag, Erdene, Sanjaa, Burmaa, Benhamou, Rita Ait, El Azhari, Abdessamad, Ghita, Bennis, Lhassani, Sara, Louraoui, Sidi Mamoun, Rghioui, Mounir, Saaf, Sarra, Gadouali, Taha, Gouazar, Iltimass, Korch, Moniba, Letrache, Ahmed, Louari, Amina, Zamame, Anas, Ousouss, Samia, Zekhnini, Meryem, Abderrazaq, Hafni, Abichou, Wijden, Ahlaou, Hamza, Baicha, Amal, Baroudi, Salma, Chaoui, Ghita, El Azzazi, Hind, El Masaoudi, Saja, Hassoun, Chiraz, Moujtahid, Hajar, Riyahi, Anas, Zaim, Ouijdane, Aji, Narjiss, Ammouze, Imane, Arkha, Yasser, Bechri, Hajar, Belabbes, Meryem Benchekroun, Benslimane, Zaineb, Boualila, Lina, Bouanani, Othmane, El Ouahabi, Abdessamad, Hossyni, Leila Essakalli, Malik, Boulaadas, Oudrhiri, Mohammed Yassaad, Sefrioui, Taha Ismail, Tagmouti, Adam, Bensghir, Mustapha, Elkoundi, Abdelghafour, Belarabi, Othman, Belkhadir, Zakaria Houssaïn, Benkabbou, Amine, Boutayeb, Saber, El Ahmadi, Brahim, El Bouazizi, Yassine, Ghannam, Abdelilah, Kabbaj, Taha, Majbar, Anass Mohammed, Mohsine, Raouf, Souadka, Amine, Kone, Badra Aliou, Ndatewapo, Fillipus, Njuki, Peter Ngungi, Abrahams, Jenevive, Jeketera, Clara, Yeboah, Kwasi, Abebrese, John Tabiri, Mureko, Alfred, Quayson, Francis William, Shikongo, Justina, Bhusal, Subarna, Dwa, Yam, Joshi, Ashoo, Berkeveld, Eva, Bloemers, Frank, Borgstein, Alexander, Gisbertz, Suzanne, Mikdad, Sarah, Berge Henegouwen, Mark, Bakx, Roel, Besselink, Marc, Lemmers, Daniel HL, Roelofs, Anne‐jasmin, Amstel, Paul, Helsdingen, Claire, Smeele, Ludi, Harlaar, Niels, Jonker, Frederik, Burg, Sjirk, Oostendorp, Justin Y., Ombashi, Saranda, Voort, Tim, Geldorp, Martijn, Posma‐bouman, Lisanne, Boer, Hans Donald, Olieman, Annette, Smid‐nanninga, Henriette, De Vries, Jean‐Paul P. M., Hogenbirk, Rianne, Derksen, Tyche, Franken, Josephine, Oosterling, Steven, Nolte, Peter, List, Jelle, Alwayn, Ian, Bijlstra, Okker, Braat, Andries, Bulder, Ruth, Kok, Michèle, Faber, Robin, Goudsmit, Ben, Hamming, Jaap, Mieog, Sven, Vahrmeijer, Alexander, Leemkolk, Fenna E. M., Vorst, Joost, Schaik, Jan, Verhagen, Merel, Albers, Kim, Gawria, Larsa, Van Goor, Harry, Warle, Michiel, Ginhoven, Tessa M., Viëtor, Charlotte, Boerma, Evert‐jan, Lallitsch, Lara, Schweitzer, Donald, Leclercq, Wouter, Sijmons, Julie, Vancoillie, Peter‐jan, Konsten, Joop, Heinsbergen, Maarten, Dekker, Nicole, Boer, Frank, Dimech, Julian, Djamali, Kaveh, Fowler, Carolyn, Ghamri, Naji, Houston, Helen, Joseph, Reece, Kantroo, Astha, Kwun, Jin, Lie, Samuel, Lightfoot, Nicholas, Maccormick, Andrew, Olliff, Sue, Trilokekar, Natasha, Wood, Daniel, Ekanayaka, Aruna, Furkert, Chris, Nanayakkara, Asanga, Panesar, Divyansh, Waddell, Oliver, Bidois, Lauren, Clifford, Zoe, Frizelle, Frank, Glyn, Tamara, Lim, Eric, Lyons, Oliver, Mclauchlan, Jared, Nicholas, Ella, O’Grady, Michael, Roake, Justin, Singh, Harsh, Ailabouni, Ramez, Rietveld, John, Alqassab, Mohammed, Amer, Mostafa, Chan, Annie, Egbuji, John, Fullarton, Mairi, Haddow, James, Hawkins, Robyn, Vui Teck, Lu, Oliver, Thomas, Saw, Kai Sheng, Sugunesegran, Ramanen, Wilkins, James, Woodfield, Esther, Baker, Joseph, Cama, Jitoko, Field, Xavier, Fulivai, Alamea, Hossain, Ruhella, Kelly, Ben, Jasen, Ly, Mckelvie, James, Meiyappan, Vivek, Cindy Xin Yi, Ou, Singh, Vidit, Hedley, Alex, Temara, Hinerangi, Aitken, Jake, Frunt, Brytt, Boys, Max Hardie, Lakshman, Prashant, Pinfold, Esther, Cowan, Sarah, Henderson, Nigel, Leary, Jessica, Castle, Cameron, Gaston, Matt, Haimona, Maira, Jury, Steffanie, Lahood, Zoe, Lim, Matthew, Macintyre, Dillon, Mak, Josephine, Neal, Annelise, Shelker, William, Weeratunga, George, Ferguson, Liam, Harmston, Christopher, Heaven, Chelsea L, Watt, Imogen, Cahill, Henry Witcomb, Abdurrazzaaq, Abdussemee, Abdussalam, Hameedat Opeyemi, Adebanjo, Ademola, Ahmed, Aminat Olayinka, Borokinni, Opeyemi Busayo, Fasiku, Olushola Kayode, Gwaram, Usman, Okoye, Onyedika, Olaomi, Oluwole, Adeyeye, Ademola, Enoch, Elizabeth, Fayose, Samuel, Kayode‐nissi, Victor, Kadiri, Innih, Oduah, Stella, Abdull, Mohammed, Abdullahi, Mohammed Kabir, Kwankiyel, Auwal Babayo, Umar, Shahir Bello, Hassan, Sulaiman, Ja’Afar, Abubakar Bappah, Ja’Afaru, Umma Hani, Kadas, Saidu, Liman, Haruna, Makama, Baje, Mohammad, Aminu Mohammad, Kirfi, Abdullahi Musa, Oyediji, Funmilayo, Mohammed, Husseini Yakubu, Akpoghor, Oghenevwegba, Arekhandia, Alexander, Dawodu, Oseyi, Edetanlen, Ekaniyere, Efobi, Chizoba, Egbor, Esezobor, Enaruna, Nosakhare, Ezeanochie, Michael, Ezenwa, Ekene, Ijekeye, Ferdinand, Imumoren, Joe, Iribhogbe, Oseihie, Irowa, Omorodion, Momoh, Moses, Nwashilli, Nnamdi, Obahiagbon, Osarobo, Obuekwe, Ozoemene, Odai, Emeka Danielson, Odigie, Vincent, Odutola, Oluwatomi, Okhakhu, Amina, Okugbo, Stanley, Oni, Samson, Onyeagwara, Ngozi, Oseghale, Eustace, Osemwegie, Osarenkhoe, Osho, Philip, Ugwi, Veronica, Uwagboe, Charles, Yusuf, Sofiat, Abiodun, Adekunle, Akinloa, Olufemi, Shodipo, Moses, Abdullahi, Alhassan, Lawal, Ishak, Echieh, Chidiebere Peter, Nwagboso, Chimaobi, Udoh, Ubong, Akanni, Bolaji, Anyimba, Solomon, Chukwu, Isaac, Ezomike, Uchechukwu, Gold, Ikponmwosa, Nnabugwu, Ikenna, Nwafor, Ikechukwu, Okolie, Louis, Okoro, Kelechukwu, Okwara, Blasius, Onyemaechi, Ndubuisi, Abdulsalam, Khalifa, Arogundade, Abayomi, Kura, Mohammed, Nwosu, David, Abdullahi, Habiba, Agida, Eyaofun, Aisuodionoe‐shadrach, Oseremen, Ajibola, Hafees, Akaba, Godwin, Ale, Omolabake, Atim, Terkaa, Emeka, Malachy Ayogu, Benard, Adeka, Buba, Amina, Chinda, John, Edino, Stephen, Eniola, Sefiu, Garba, Stephen, Isah, Aliyu, Isah, Dennis Anthony, Joshua, Zaman, Mbajiekwe, Ndubuisi, Mshelbwala, Philip, Muhammad, Rafat, Offiong, Richard, Olute, Anne, Osagie, Olabisi, Ogolekwu, Idoko Pius, Sulaiman, Bilal, Suleiman, Salisu, Umar, Aminu, Abayomi, Olukayode, Abdus‐salam, Rukiyat, Adebayo, Sikiru A., Adeleye, Amos, Ademola, Samuel, Afuwape, Oludolapo, Ajao, Akinlabi, Akinsola, Sanusi, Aladelusi, Timothy, Ayandipo, Omobolaji, Baiyewu, Lateef Ayodele, Balogun, Mosimabale, Daodu, Israel, Egbuchulem, Ifeanyichukwu Kelvin, Elemile, Peter, Ezeme, Constantine, Fasunla, Ayotunde James, Gbolahan, Olalere, Iwuagwu, Ifeanyi, Michael, Afieharo, Morhason‐bello, Jemiludeen, Nwaorgu, Onyekwere, Obadan, Izegaegbe, Odeyemi, Olubunmi, Ogundoyin, Omowonuola, Ogundoyin, Olakayode, Ogunkeyede, Segun Ayodeji, Ogunrewo, Tolulope, Okere, Oghenekevwe, Oladejo, Titilola, Oladiran, Ajibola, Olagunju, Naomi, Olaoye, Ifedolapo, Olawoye, Olayinka, Olulana, Dare, Olusanya, Adeola, Omigbodun, Akinyinka, Onakoya, Paul, Orji, Mathias, Oyelakin, Oyeleye, Oyewole, Olugboyega, Sule, Samuel, Takure, Augustine O, Ugwu, Ebere, Afolabi, Bosede, Ajayi, Peter, Akinajo, Opeyemi, Alakaloko, Felix, Atoyebi, Oluwole, Belie, Orimisan, Bode, Chris, George, Ihediwa Chibuike, Elebute, Olumide, Ezenwankwo, Francis, Fatuga, Adedeji, Ladipo‐ajayi, Oluwaseun, Makanjuola, Ayomide, Makwe, Christian, Mofikoya, Bolaji, Ohazurike, Ephraim, Ojewola, Rufus Wale, Okunade, Kehinde, Okunowo, Adeyemi, Olajide, Thomas Olagboyega, Oni, Oluwafemi, Tijani, Kehinde, Ugburo, Andrew, Ugwu, Aloy Okechukwu, Abiola, Paul, Abiyere, Henry, Adebara, Idowu, Adeniyi, Adebayo, Adeyemo, Olabisi, Ariyibi, Abimbola, Babalola, Olakunle, Bakare, Adewumi, Banjo, Oluseyi, Egharevba, Peter, Obateru, John, Ojo, Owolabi, Olajide, Adewale, Oluwafemi, Fatudimu, Oyeleye, Oluwole, Salawu, Adedayo, Babatunde, Bakare Tajudeen Ishola, Abdulsalam, Moruf, Adelaja, Aderinsola, Adeniran, Abimbola, Ajai, Olalekan, Atobatele, Kazeem, Ayodele, Olabamidele, Bello, Funmi, Faboya, Omolara, Idowu, Olufemi, Idowu, Jeuel, Mustapha, Muntaqa, Omisanjo, Olufunmilade, Osuoji, Roland, Vitowanu, Julius, Abe, Anthonia, Aderounmu, Adewale, Adesunkanmi, Abdulhafiz, Ajekwu, Temitope, Ajekwu, Samuel, Ajiboye, Olalekan, Aderogba, Adeleke Akeem, Alatise, Olusegun Isaac, Babatunde, Mustapha, Balogun, Simon, Ijarotimi, Adebimpe, Lawal, Adedayo, Ojo, Olugbenga, Olasehinde, Olalekan, Olugbami, Adebayo, Ubom, Akaninyene Eseme, Agbaje, Ademola, Mohammed, Tajudeen, Adeniran, Abiodun, Adesola, Muideen, Afolabi, Abdulrahman O., Aremu, Isiaka, Ayinmode, Iyehunwa, Bello, Jibril, Ezeoke, Grace, Gwadabe, Sadiya, Ibraheem, Gbadebo, Ibrahim, Saidu, Ijaiya, Munir’Deen, Nasir, Abdulrasheed, Odeyemi, Peter Olalekan, Ogunade, Olukayode, Olabinjo, Afusat, Olatoke, Samuel Adegboyega, Olowogbayi, Tope, Onjefu, Stephen, Popoola, Ademola, Raji, Hadijat Olaide, Salawu, Nasiru, Salawu, Hafeez, Sayomi, Tolulope Olayinka, Segun‐busari, Segun, Uche‐okonkwo, Kenechukwu, Abiola, Olajide, Anipole, Olalekan, Ogunlaja, Olumuyiwa, Adesina, Oluwaseyi, Alayande, Barnabas, Ebenezer, John, Enwerem, Kenneth, Isichei, Christian, Isichei, Mercy, Luku, Pwaluke, Omiragi, Paul, Onyeji, John, Adze, Joel, Aghadi, Ifeanyi, Auta, Akawu, Duniya, Sharon, Gyuro, Joseph, Lawal, Jamila, Makama, Jerry Godfrey, Mohammed, Garba, Mohammed‐durosinlorun, Amina, Salisu, Kabiru, Taingson, Matthew, Yusuf, Nuhu, Amos, Happy, Daniel, James, Takai, Idris Usman, Abdullahi, Lawal, Abdullahi, Sani, Abdulrahman, Mamuda, Abubakar, Mohammed Kabir, Adikaibe, Valentine, Ahmad, Misbahu, Ahmad, Jameel Ismail, Aji, Sani Ali, Aliyu, Mohammed Salele, Danagundi, Maryam Babba, Bako, Yusuf Halidu, Bello‐muhammad, Nafisatu, Garzali, Ibrahim Umar, Hasheem, Muhammad Ghazali, Hassan, Ismail, Hassan, Sadiq, Usman, Mustapha Ibrahim, Ismail, Nasiru, Jibril, Yasir Nuhu, Kurawa, Musbahu, Magashi, Mahmoud Kawu, Martins, Bardi, Bello, Usman Mohammed, Muhammad, Saminu, Muhammad, Abubakar Bala, Muhammad, Shamsuddeen, Daneji, Sulaiman Muhammad, Mukhtar, Ibrahim Aliyu, Adamu, Kabir Musa, Nwachukwu, Callistus, Omeje, Uchenna Kelvin, Orji, Ifeanyi James, Sheshe, Abdurrahman Abba, Suleiman, Ibrahim, Yunusa, Sani Abdullahi, Maryam, A, Abubakar, Kabiru Bello, Habib, Saudat Garba, Mahmood, Farrukh, Alabi, Ibrahim Abolaji, Arojuraye, Soliudeen, Salihu, Mohammed, Alade, Samuel, Kumolalo, Felix, Mogbo, Chiedozie, Adebayo, Olaolu, Ige, Oluwasuyi, Jones, Gbenga, Odunafolabi, Tunde, Olubayo, Oluniyi Oyetunde, Akani, Chris, Alasia, Datonye, Alegbeleye, Justina Omoikhefe, Aria, Oti Nimi, Awopeju, Abimbola, Edonkumoh, Kemebradikumo, Ekeke, Onyeanunam, Fyneface‐ogan, Sotonye, John, Celestine, Kasso, Terhemen, Korubo, Inye, Mato, Christie, Ogu, Rosemary, Okpani, Charles, Okpani, Anthony, Onwuagha, Ijeoma, Oppah, Ijeoma, Oputa, Victory, Oranu, Emmanuel, Orazulike, Ngozi, Otokwala, Job, Ugboma, Henry A. A, Ajayi, Adekunle, Ogundele, Ibukunolu, Salami, Babatunde, Ajagha, Okeoghene, Ali, Yakubu, Awaisu, Mudi, Daniyan, Muhammad, Fidelis, Lovely, Nwabuoku, Stanley Emeka, Ogunsua, Oluseyi, Oyelowo, Nasir, Sholadoye, Tunde T., Yakubu, Alfa, Rendevski, Vladimir, Shuntov, Blagoj, Shuntov, Natalija Cokleska, Georgieva, Gordana, Jovanoski, Tomislav, Jovanovska, Katerina, Nikolovska, Bisera, Peev, Igor, Srbov, Blagoja, Trajkova, Andrijana, Trenchev, Viktor, Dohcev, Sasho, Janchulev, Josif, Saidi, Skender, Stankov, Oliver, Trifunovski, Aleksandar, Draz, Najib Abu, Al Ajmi, Khalil, Al Ajmi, Ghadeer, Al Amri, Ayman, Al Badaai, Ghalib, Al Balushi, Nawf, Al Bassam, Wameedh, Al Farsi, Maather, Al Ghafri, Wadha, Al Ghafry, Alaa, Al HOSNI, Mohammed, Al Kalbani, Moza, Al Kalbani, Maha, Al Kharusi, Lamya, Al Kharusi, Safiya, Al Mutani, Mohammed, Al Qadhi, Hani, Al Raisi, Amani, Al Riyami, Nihal, Al Sabti, Hilal, Al Shaibi, Maha, Al‐abri, Rashid, Al‐mujaini, Abdullah, Al‐rashdi, Aya, Alajmi, Suha, Albadi, Zamzam, Albusaidi, Hanadi, Alhadeethi, Ahmed, Aljabri, Noor, Alkazrooni, Muhannad, Alkharousi, Nadiya, Alkharusi, Al‐salt, Alkiyumi, Khadija, Almaharbi, Noof, Alsaadi, Sabaa, Alsharji, Marwa, Alsharqi, ALi Hamed, Alshehhi, Fatma, Alsulaimani, Thuwaiba, Alward, Mustafa, Alwashahi, Mohammed, Alyafii, Hussain, Alzadjali, Adil, Basi, Tayseer, Dalmar, Khadija, Dawud, Bashar, Gargouri, Mohamed Mourad, Kariyattil, Rajeev, Kenawy, Ahmed Omer, Kochummen, Koshy, Kolethekkat, Arif, Pillai, Mahesh Krishna, Sureshkannan, Ks, Laghari, Farman Ali, Manjunatha, Attibele Palaksha, Mathew, Joseph Kunju, Muzaffar, Rahil, Nair, Asha, Naiya, Hafsa Ismail Ibrahim, Nazar, Zuhail, Pillai, Silja, Rahim, Ferdous, Rahman, Khalid, Sheik, Shahila, Siddiqi, Mohammad Salman, Stephen, Edwin, Younas, Shahzad, Fatima, Mishal, Javed, Ayesha, Khan, Muhammad Ahsan, Shakir, Fatima Tuz Zahra, Siddiqui, Riaz Hussain, Syed, Danish, Rehman, Ishtiaq Ur, Warraich, Shahrukh, Amir, Mohammed, Asghar, Saleha Yurf, Bangash, Ali Haider, Latif, Sehrish, Naqvi, Wajih, Abdullah, Muhammad Tariq, Abdullah, Saleha, Ahmed, Arooj, Ahsan, Muhammad Fahim Ahsan, Akhtar, Fahad, Ali, Sana, Ansar, Mehwish, Aqib, Muhammad, Arslan, Muhammad, Ashraf, Sumaira, Ayubi, Azaz, Azam, Tayyab, Bhatti, Hamza, Huda, Shahab, Irshad, Abeer, Ishaque, Nazia, Khaliq, Tanwir, Khan, Farheen, Khan, Mumtaz Ahmad Khan, Mahmood, Namrah, Malik, Ali Raza, Malik, Tahir, Malik, Komail, Mehmood, Manzer, Mustafa, Fatima, Noor, Fazal, Nubair, Sarwar, Rashid, Isbah, Saeed, Waqar, Sajid, Hannan, Shah, Sajid, Shami, Ali, Siraj, Minhaj Us Siraj, Tareen, Mariam, Haq, M Burhan Ul, Abbas, Manzar, Zaidi, Syeda Maria Ahmad, Ahmed, Iffat, Ahmed, Shahnoor, Ahsan, Kunwar Armash, Akhtar, Munazza, Akhund, Ramsha, Manji, Adil Al‐Karim, Arshad, Hajra, Awan, Muhammad Ozair, Aziz, Humaira, Bhutto, Shameen, Aamir, Faiqa Binte, Biyabani, Syed Raziuddin, Chishti, Uzma, Chundrigar, Mohsin, Ghaloo, Shayan Khalid, Haroon, Waqqas, Hashmi, Shiraz, Hassan, Murtuza, Inam, Hina, Kassam, Nausheen, Kazmi, Abbas, Khan, Majid, Khan, Muhammad Osama, Kumari, Sameeta, Malik, Muhammad Jehangir, Mansoor, Maheen, Martins, Russell Seth, Mubarik, Areeba, Munir, Muhammad Musaab, Musharraf, Muhammad Bazil, Naz, Falak, Noordin, Shahryar, Pervaiz, Arsalan, Qamar, Javeria Bilal, Rahman, M Fazlur, Rani, Pallavi, Rasheed, Yasir, Sadia, Haleema, Saeed, Marwah, Safri, Mohammad, Salim, Shaharyar, Sattar, Abida K., Shamim, Shahzad, Sherwani, Maryam, Siddiqui, Muhammad Ahsan Iqbal, Sidhwa, Astad, Tariq, Javeria, Tejani, Isbaah, Waqar, Usama, Zahid, Fahad, Jamal, Abid, Ghufran, Muhammad Ali, Memon, Amjad Siraj, Saeed, Summaya, Samo, Khursheed Ahmed, Aswani, Manisha, Manzoor, Shahneela, Muhammad, Shoaib, Arshad, Muhammad, Hussain, Syeda Namayah Fatima, Moin, Inshrah, Najjad, Muhammad Kazim Rahim, Nasir, Manal, Sohail, Osama Bin, Mangi, Ali, Markhand, Naveed, Mushtaq, Hassan, Zia, Kashif, Ahmed, Hassaan, Ahmed, Nasir, Qureshi, Talha Ahmed, Shaikh, Shafqat Ali, Anwer, Rabia, Arshad, Owais, Batool, Sehrish, Chatni, Muhammad, Chundrigar, Tariq, Dojki, Samina Saleem, Elahi, Minahil, Farooqui, Bakhtawar, Ghouri, Amna, Hassan, Nabeel, Hussain, Zainab, Hussaini, Null, Iftikhar, Fizza, Iqbal, Faizan, Javed, Anum, Javed, Dania, Kamal, Wajahat, Khan, Shifa, Mughal, Zeeshan Uddin, Murtaza, Ghulam, Nadeem, Areeba, Nasir, Areeba, Nayyer, Fatima, Nisa, Kanwal, Rauf, Yaseen, Haroon, Umer Saeed, Saleem, Shah Masabat, Seriwala, Haseeb, Shah, Aaqil, Siddiqui, Safia, Tanveer, Asher Tanweer, Tariq, Nida, Zaman, Junaid, Zamir, Mehroz, Anjum, Muhammad Ayyub, Afzal, Ameer, Ahmed, Ehsan, Ahmed, Jawad, Riaz, Shujat Ahmed, Akbar, Ali, Akbar, Bilal, Ali, Maria, Ali, Imran Ali, Ali, Abrar Ashraf, Ali, Ghazanfar, Altaf, Zahra, Ammar, Ahmed Siddique, Arif, Hafiz Muhammad Arif, Aslam, Imran, Bashir, Muhammad Mustehsan, Farooq, Usman, Farooq, Muhammad, Gondal, Khalid Masood, Iqbal, Muhammad Javed, Iqbal, Zafar, Ismail, Fahad, Jameel, Muhammad Khurram, Janjua, Muhammad Haris, Janjua, Azwa, Joshi, Prabesh, Khadam, Mamoona, Khan, Romaisa, Khawaja, Muhammad Asadullah, Manzoor, Sobia, Mohsin, Muhammad, Mumtaz, Khizra, Musaab, Muhammad, Naqi, Syed Asghar, Naumeri, Fatima, Nazir, Umer, Noureen, Sadaf, Rafi, Yaseen, Raza, Ali, Rijal, Sushil, Saleem, Irfan, Shah, Hafiz Syed Zaigham Ali, Sharif, Muhammad, Shaukat, Ayesha, Siddique, Usman, Sikandar, Hafiz Saqib, Sohail, Mohammad, Zahara, Fatima Tu, Usman, Yasmeen, Zaman, Balakh Sher, Zeb, Misbah, Afzal, Muhammad Farooq, Ahmad, Fateen, Ahmed, Waqas, Akram, Shahzad, Alam, Azhar, Ali, Danish, Ali, Ahsan, Alvi, Ammar Tariq, Asif, Suleman Asif, Aslam, Madiha, Daood, Muhammad Daood, Jawad, Muhammad, Kathia, Usama Muhammad, Khalid, Ismaeel, Khan, Anwar, Khurshid, Zain, Noman, Hamza, Raza, Ahsan, Taha, Hassan, Zubair, Muhammad, Maria, Noor Ul Huda, Janjua, DrAtif A, Ahmad, Qamar Ashfaq, Ahmad, Sheraz, Ali, Imran, Amin, Sana, Anjum, Momina, Asjad, Muhammad, Aslam, Aatif, Ayyaz, Mahmood, Bajwa, Luqman Ali, Bakhtiar, Akkasha, Bashir, Alia, Batool, Fizza, Bhatti, Samiullah, Butt, Roshan, Butt, Usman, Changazi, Shabbar Hussain, Cheema, Omer Iqbal, Chishti, Muhammad Haris, Haq, Bushra, Hashmi, Ali, Hassan, Muhammad, Hassan, Usman, Hayat, Khizar, Iqbal, Javaid, Iqbal, Ayesha, Ishaq, Amna, Javed, Sundas, Javed, Hina, Javed, Aymen, Kashif, Muhammad, Khalid, Muhammad Saud, Khan, Wasim Hayat, Khan, Rohma, Khan, Fatima, Latif, Usman, Mahmood, Arif, Majeed, Faizan, Malik, Kiren, Masood, Rumaisa, Munawwar, Fasiha, Mushtaq, Asma, Nabi, Muhammad Shoaib, Nasir, Ahmad, Naureen, Shazia, Noreen, Zahida, Qadir, Muhammad Ghulam Qadir, Raana, Gul e Raana, Rashid, Madeeha, Rehman, Abdul, Riaz, Sidra, Saboor, Arfa, Sadiq, Muhammad Hamza, Saeed, Komal, Saleem, Humaira, Sarfraz, Kiran, Shafiq, Zahid, Shafqat, Aymen, Shaukat, Hassan, Sher, Fateh, Sohail, Rubina, Suhail, Amina, Muhammad, Bilal Syed, Umair, Usama, Umar, Muhammad, Usama, Muhammad, Usman, Natasha, Waheed, Kalsoom, Farooka, Muhammad Waris, Wasim, Shafqat, Wasim, Tayyiba, Yasin, Fahad, Zafar, Zain, Zaka, Sabahat, Zaman, Salma Zaman, Azad, Junaid, Fatima, Zareen, Anwar, Muhammad Imran, Naseer, Muhammad Ahmed, Shah, Muhammad Taimoor, Ali, Ammar, Aslam, Muhammad, Aziz, Muhammad Usama, Gohar, Farhan, Humayoun, Waseem, Khan, Hassan, Naeem, Shiza, Tahir, Warda, Alvi, Kashif, Mehmood, Maria, Ali, Muhammad, Shahzad, Aniqa, Sher, Muhammad, Murtaza, Null, Siddique, Hijab, Anjum, Waleed, Ahmad, Manzoor, Alam, Muhammad, Faizi, Fouzia, Faridoon, Shehla, Hussain, Musarrat, Iftikhar, Muhammad, Jan, Yousaf, Kalim, Muhammad, Raza, Tilal Ahmed, Shah, Farrukh Ozair, Shah, Muhammad, Tahir, Imran, Khan, Hamza, Naeem, Muhammad, Ahmad, Shabir, Ahmed, Haseeb, Akbar, Hazrat Akbar, Akhtar, Muhammad Shaheer, Ali, Noman, Ali, Mehboob, Ali, Sadaf, Ali, Irfan, Amin, Hasbi Allah, Amin, Shehzadi, Ayub, Bakhtawar, Basir, Muhammad, Faraz, Ahmad, Farsi, Muhammad Salman, Gul, Ambrin, Gul, Hina, Gul, Ayaz, Gul, Sana, Haider, Sajjad L, Ikramullah, Syed Ikramullah, Jan, Kashif, Khalid, Muhammad, Khan, Salman, Khan, Muhammad Faisal, Khan, Faraz Ahmad, Mian, Iftikhar, Moeen, Aiman, Mohmand, Obaid, Rahim, Rehana, Raziq, Naila, Rehman, Riaz, Salim, Azra, Shafqat, Tanveer, Shah, Faaiz Ali, Shah, Suliman, Shakeel, Muhammad, Ullah, Tahsin, Rehman, Shams Ur, Wali, Sabaeena, Zahoor, Farnaz, Zeb, Gulmeena, Zeb, Laila, Haseeb, Null, Raza, Waqas, Amir, Zein, Arshad, Daneyal, Daud, Mashal, Chughtai, Umer Javed, Rauf, Mirza Hammad, Sajid, Zaina, Abid, Rubaba, Azam, Ayesha, Farkhanda, Tallat, Firdos, Kanwal, Khalid, Tabinda, Malik, Sobia, Mashal, Javeria, Salim, Ruqyyah, Saqib, Madiha, Shaheen, Aneela, Shahid, Madiha, Yasmeen, Irfana, Ahmed, Faryal, Ali, Aneeqa, Amjid, Zarafshan, Anwar, Muhammad Idrees, Arif, Iqtaza, Ashraf, Anam, Butt, Adam Umair Ashraf, Azhar, Faryal, Daniyal, Muhammad Daniyal, Ghazanfor, Ramlah Ghazanfor, Ishtiaq, Daniyal, Jamil, Manahil, Khalid, Ziaullah, Khan, Jahangir Sarwar Khan, Khan, Muhammad Sarfraz, Mahmood, Usama, Mahmood, Ashraf, Malik, Abdur Rehman, Nagra, 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A., Jobran, Fahmi, Lahlooh, Raghad, Aburayyan, Fatima, Abuzaina, Khalil, Aljuba, Ayat A., Aljunaidi, Roaa, Alzughayyar, Tareq, Amro, Adham, Amro, Sarah, Dweik, Mays, Halman, Safa, Qafisha, Qutaiba, Shaheen, Farah, Shawer, Balqis, Shehadeh, Daleen, Zalloum, Jihad, Demyati, Khaled, Hajhamad, Mohammed, Saqfalhait, Zain, Del Cid, Emmy Arrue, Rodriguez‐zentner, Homero, Abed, Francisco, Garayo, Rafael Osmar Adorno, Aguilar, Ruben, Aguilar, Ana, Maidana, Domingo Javier Aguilera, Casañas, Diego José Almada, Almiron, Teresa, Arrua, Analia, Avila, Pedro, Balmaceda, Brenda, Barreto, Alexandra, Galeano, Analy Barreto, Nuñez, Belinda Barrientos, Benegas, Magdalena, Berden, Martin, Bogarin, Amalia, Bonnin, Jorge, Barrios, Edulfo Britez, Burgos, Julio, Melgarejo, Carlos Fabián Cárdenas, Samudio, José De Jesus Casco, Cataldi, Sandra, Centurion, Jorge Augusto, Ramirex, Luz Maria Cespedes, Colina, Katerine, Almando, Gabriel Augusto Cuevas, De Bleecker, Karina, Dragotto, Antonella, Eiwa, Eiji, Enciso, 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F. F., Li, E., Picciochi, M., Glasbey, J. C., Baiocchi, G., Blanco-Colino, R., Chaudhry, D., Alameer, E., El-Boghdadly, K., Wuraola, F., Ghosh, D., Gujjuri, R. R., Harrison, E. M., Lule, H., Kaafarani, H., Khosravi, M., Kronberger, I., Leventoglu, S., Mann, H., Mclean, K. A., Mengesha, M. G., Modolo, M. M., Ntirenganya, F., Norman, L., Outani, O., Pius, R., Pockney, P., Qureshi, A. U., Roslani, A. C., Satoi, S., Shaw, C., Bhangu, A., Omar, O. M., Ahmed, W. -U. -R., Argus, L., Ball, A., Bywater, E. P., Brar, A., Dawson, B. E., Duran, I., Elhadi, M., Jones, C. S., Kamarajah, S. K., Keatley, J. M., Lawday, S., Marson, E. J., Ots, R., Santos, I., Taylor, E. H., Trout, I. M., Varghese, C., Venn, M. L., Xu, W., Dajti, I., Gjata, A., Kacimi, S. E. O., Boccalatte, L., Cox, D., Townend, P., Aigner, F., Kronberger, I. E., Samadov, E., Alderazi, A., Hossain, K., Padmore, G., van Ramshorst, G., Lawani, I., Cerovac, A., Delibegovic, S., Gomes, G. M. A., Buarque, I. L., Gohar, M., Slavchev, M., Nwegbu, C., Agarwal, A., Martin, J., Ng-Kamstra, J., Olivos, M., Lou, W., Ren, D. -L., Calvache, J. A., Perez Rivera, C. J., Hadzibegovic, A. D., Kopjar, T., Mihanovic, J., Jimenez, P. M. A., Gouvas, N., Klat, J., Novysedlak, R., Amisi, N., Christensen, P., El-Hussuna, A., Batista, S., Lincango-Naranjo, E., Emile, S., Sandoval, D. A. A., Dhufera, H., Hailu, S., Kauppila, J. H., Arnaud, A. P., Demetrashvili, Z., Albertsmeier, M., Lederhuber, H., Loffler, M. W., Acquah, D. K., Ofori, B., Tabiri, S., Metallidis, S., Tsoulfas, G., Aguilera-Arevalo, M. -L., Recinos, G., Mersich, T., Wettstein, D., Kembuan, G., Milan, P. B., Khosravi, M. H., Mozafari, M., Hilmi, A., Mohan, H., Zmora, O., Gallo, G., Pata, F., Pellino, G., Fujimoto, Y., Kuroda, N., Abou Chaar, M. K., Ayasra, F., Fakhradiyev, I., Hamdun, I. H. S., Jin-Young, J., Jamal, M., Karout, L., Gulla, A., Rasoaherinomenjanahary, F., Samison, L. H., Sanchez, I. I. D., Gonzalez, D. 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H., Datler, P., Dawoud, C., Farr, A., Foessleitner, P., Grimm, C., Harpain, F., Hoda, M. A., Holawe, S., Kranawetter, M., Ott, J., Perricos, A., Pesta, M., Pillerstorff, R., Reiterer, C., Riss, S., Rosta, K., Scheriau, G., Tschernko, E., Wenzl, R., Wiedemann, D., Wohlrab, P., Zapletal, B., Zimmermann, M., Zimpfer, D., Findl, O., Fisus, A., Ruiss, M., Komaz, M., Meindl, N., Primavesi, F., Stadlbauer, K. H., Stattner, S., Steiner, F., Cerny, O., Falkensammer, E., Knotzer, H., Koglberger, P., Poidinger, B., Wiesinger, C. G., Burtscher, J., Rath, S., Trivik-Barrientos, F., Aliyeva, G., Behbudov, V., Muslumov, G., Zeynalov, N., Alam, M., Alfayez, F., Hasan, B., Mahdi, M., Mulla, H., Qader, K., Saeed, A., Shirazi, A., Albastaki, A., Birido, N., Chagla, H. H., Dawaishan, A., Dawaishan, B., Farhan, A., Juma, I., Khan, A., Patel, A. M. E., Srinivasan, M., Deen, F. W. A. M. A. N., Abdulqadir, S., Jabr, A., Maqsood, F., Almoosa, N., Naseer, M., Alam, M. S., Basher, A. K. M. K., Islam, S. M. N., Karim, S., Faisel, M., Khan, S., Mannan, I. I., Nazia, N., Bentham, M., Corbin, S., Doyle, A., Eastmond, A., Haynes, A., O'Shea, M., Phillips, E., Walkes, K., Artyushkov, E. L., Kaplan, M. L., Straltsov, V., Litvina, Y., Lyzikov, A., Tihmanovich, V. E., Borges, M., Brits, T., De Hous, N., De Wachter, S., Menovsky, T., Mortiers, X., Vermeulen, D., Vleminckx, N., Ysebaert, D., Bontinck, J., Bulthe, D., Rasschaert, R., Van Haver, A. -S., Van Belle, K., Verstraeten, L., Vounckx, M., D'Ulisse, S., De Bruyne, Y., El Nakadi, B., Heloise, T., Luisetto, M., Marinakis, S., Maton, M., Viste, C., Van Daele, E., Vandeputte, M., Duinslaeger, M., Jacobs-Tulleneers-Thevissen, D., Jansen, Y., Janssens, W., Kunda, R., Messaoudi, N., Ruyssers, M., Van Eetvelde, E., Vanhoeij, M., Van den Eynde, J., Van den Eynde, R., Chaoui, A. M., Akpla, M., Lawani, S., Agossou, H., Behanzin, H. A., Bokossa, C., Dewanon, H., Yome, H., Boukari, A., Gbehade, O., Amossou, L. F., Dossou, F., Barisic, T., Boras, M., Brekalo, Z., Blagojevic, I. C., Damjanovic, A., Dragisic, V., Simic, A. D., Gunaric, F., Kajic, M., Knezevic, D., Kresic, T., Lasic, V., Letica, L., Martinovic, V., Mikulic, I., Miskovic, J., Pehar, H., Rastovic, P., Sesar, I., setka-Culjak, V., Soljic, M., Tiric, D., Tomic, V., Vasilj, A., Hudic, I., Oliver, R. A., Lamonica, F. A., De Medeiros, J., Florindo, H. D. B., Filho, R. J. F., Pereira, F. C., Rodrigues, R., Junior, A. A. R., de Andrade, F. R., Salvetti, M., Campioto, D. S., Lamonica, M. T., Urbano, G., Prado, R. V., Alonso, N., dos Santos, C. F., Tonello, C., Pires, R. E., Rezende, R. F., Reis, I., Marson, F. A. L., Ferreira, E. P., Palamim, C. V. C., Brandao, M., de Souza, T. H., Maunsell, R., Neto, A. A., Accorsi, G., Fernandes, M. F., Machareth, C., Moura, B. V., Dias, V., Guarienti, L., de Sampaio, L. R., Vendrame, C., Coelho, T. A., Becker, K., Dias, A., Fachin, C. G., Gomes-da-Silva, M. M., Moraes, I., Pinto, A., Stychnicki, A. 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R., Rodrigues, D. N., Pansani, A., Rocha, M. L., Simonsen, M., Tsuchiya, D., Vasques, R., Amorim, J., Carvalho, A. A., Correia, R., dos Santos, B. C., Neto, H. J. G., Nakano, L., Pereda, M., Vasconcelos, V., Awada, J. B., Gava, G., Ijichi, T. R., Kim, N. J., Nunes, R., Pinto, F., Pereira, T. H. S., Volpe, G. J., Gatti, A., Nardi, C., Oliva, R., de Oliveira, L. B., de Carvalho, H. E. F., Ribeiro, I. P., Rodrigues, G. R. S., de Sousa, A. F. L., Chebel, M., de Sousa Fernandes, P. H., Freitas, M. A. F., da Cunha, J. 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A., Workneh, W., Genetu, S., Mebratu, E., Chanyalew, L., Deresse, T., Girma, A., Seid, M., Shimelash, D., Shitaw, A., Ayalew, T., Diress, T., Kassahun, B., Kassaye, B., Mulugeta, E., Tesfaw, G., Yimenu, B., Benecha, S., Aman, M., Mekete, A., Tesemma, A., Mohammed, A. A., Abdullahi, Y. Y., Adem, E., Ahmedin, M., Assefa, Y., Ayde, F., Berhe, A., Gebremeskel, Z., Siyoum, E. G., Teresa, S., Wude, Z., Yemer, F., Yohannes, D., Zeleke, E., Zerihun, G., Degefe, D. W., Derilo, H. T., Eliyas, N., Bayissa, F., Deressa, Y., Gemechu, L., Gurmu, T., Kasaye, A., Melese, L., Muleta, L., Mulugeta, G., Taye, S., Teshome, A., Tesso, B., Gebrekirstos, G., Haile, M., Kassa, H., Saddik, M., Mengist, A., Heikkinen, J., Helminen, O., Huhta, H., Kotkavaara, T., Mosorin, M. -A., Pitkanen, J., Qian, C., Sinikumpu, J., Sova, H., Tastula, M., Virta, V. 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M., Salle, H., Taibi, A., Tricard, J., Usseglio, J., Chopinet, S., Gregoire, E., Delpont, M., Blanchard, C., Crenn, V., de Vergie, S., Denis, W., Fragnaud, H., Regenet, N., Rigaud, J., Varenne, Y., Anract, P., Barat, M., Biau, D., Dautry, R., Dohan, A., Idier, L., Lang, E., Thouny, C., Tzedakis, S., Audenet, F., Cazelles, A., Chamouni, A., Karoui, M., Mejean, A., Clermidi, P., Langlais, T., Leonelli, L., Maisonneuve, E., Nicolas, B., Perrot, O., Prost, D., Thomin, A., Thouement, T., Athiel, Y., Berry, R., Boddaert, G., Bonnet, S., Cathala, N., Conso, C., Denet, C., Laforest, A., Levy-Zauberman, Y., Macek, P., Mombet, A., Ollat, D., Scamporlino, A., Zadegan, F., Amine, C. A., Baratte, B., Chartier-Kastler, E., Chereau, N., Colas, P. -A., Duquesne, I., Genser, L., Petit, G. G., Goumard, C., Hasani, A., Lim, C., Martellotto, S., Melot, C., Menegaux, F., Pinar, U., Pocard, M., Roupret, M., Scatton, O., Seisen, T., Severine, N., Turco, C., Chouillard, E., Beganton, P., Frasca, D., Kerforne, T., Corbiere, L., Gasmi, A., Ghemame, M., Guerin, S., Khene, Z. -E., Livin, M., Mahmoud, F., Maillot, B., Merdrignac, A., Mouriaux, F., Robin, F., Sulpice, L., Vazeux, C., Bertheuil, N., Bonneau, S., Cazemajou, C. T., Cousin, I., Defert, C., Fustec, E., Juricic, M., Lavoue, V., Mevel, G., Timoh, K. N., Renault, A., Violas, P., Schwarz, L., Tuech, J. J., Morichau-Beauchant, T., Sauvat, F., Haddad, E., Vermersch, S., Patrizi, A., Roux, A., Aime, A., Malgras, B., Cherkaoui, Z., D'Urso, A., Felli, E., Gonzalez, C. A., Ignat, M., Mutter, D., Pessaux, P., Vix, M., Gornes, H., Vergriete, K., Berthoumieu, P., Genre, L., Le Gall, H., Pierre, T., Chalhoub, M., Del, M., Martinez, A., Fuchs-Buder, T., Vancon, A., Faya, C. A., Asaph, E., Baruwa, E., Hofman, G., Machemedze, S., Idiata, M. M., Muhemi, R., Ndizeye, O., Nkunzimana, E., O'Connor, J., O'Connor, Z., Tchoba, S., Boumas, N., Devidze, G., Pisarevi, G., Baumgarten, S., Grusser, L., Holzle, F., Kowark, P., Kowark, A., Rossaint, R., Schafer, B., Wallqvist, J., Winnand, P., Ziemann, S., Anthuber, M., Broecheler, T., Edlinger, F., Gosslau, Y., Hyhlik-Duerr, A., Maksymiw, F., Shiban, E., Sommer, F., Sommer, B., Zerwes, S., Beyer, K., Lauscher, J. C., Lee, L. D., Loch, F. N., Schineis, C., Aghalarov, I., Belyaev, O., Braumann, C., Enste, A., Fahlbusch, T., Herzog, T., Horn, J., Jedanowski, J., Knipschild, J., Luu, A. M., Mohan, P. V., Siemen, L., Slobodkin, I., Strotmann, J. J., Uhl, W., Wolf, K., Coburn, M., Egger, E., Eichhorn, K., Enderes, J., Far, F., Franzen, A., Guresir, E., Hadjiathanasiou, A., Kalff, J. C., Kohistani, Z., Manekeller, S., Mustea, A., Probst, C., Randau, T., Recker, F., Schuss, P., Strassberger-Nerschbach, N., Strieth, S., Treede, H., van Beekum, C. J., Vatter, H., Velten, M., Vilz, T. O., Wirtz, D., Wittmann, M., Behr, M., Bulian, D. R., Marche, B., Moczko, T., Otchwemah, R., Schulz, S. -A., Thomaidis, P., Bruns, C., Cursiefen, C., Domrose, C., Fuchs, H., Heindl, L. M., Mallmann, M. R., Mallmann, C., Ratiu, D. A., Canzler, U., Distler, M., Korn, S., Meisel, C., Meusel, M., Petzold, A., Praetorius, C., von Renesse, J., Weitz, J., Wimberger, P., Alkhanji, N., Fung, S., Jaber, K., Knoefel, W. T., Vay, C., Clonda, O., Cottin, T., Juodiene, E., Juodis, D., Petrovic, B., Solodarenko, O., Binder, J., Grutzmann, R., Hackner, D., Junker, S., Arsalan, M., Banek, S., Chun, F., Faqar-Uz-Zaman, S. F., Keese, D., Kluth, L., Rolle, U., Van Linden, A., Walther, T., Bayer, J., Beck, J., Fung, C., Kraus, L. M., Leiber, C., Neidert, N., Sandkamp, R., Schnell, O., Schulte, A., Strahle, J., Jarmusch, S., Novotny, H. F. G., Becker, J., Fulghum, C., Gonschor, B., Herbolzheimer, M., Nicolaiciuc, S., Trulson, A., Vogelsang, H., Zimmermann, B., Akbari, A. A., Boening, A., Edinger, F., Hecker, M., Knitschke, M., Koch, C., Reichert, M., Schmidt, G., Schneck, E., Uhl, E., Nobrega, S. F., Kauffmann, P., Miller, C., Nemeth, M., Sievers, D., Kisser, U., Kleeff, J., Klose, J., Lorenz, K., Papendick, N., Plontke, S., Seiwerth, I., Steer, S., Thomssen, C., Ukkat, J., Dumpies, C. W., Gessner, M., Hanke, J., Klauke, F., Leuschner, S., Mendel, T., Muller, K., Schmidt, B., Schreiter, V., Stosberg, P., Vinz, F., Herbig, B., Sander, J., Schulte, T. M., Betz, C. S., Bewarder, J., Bier, J., Bottcher, A., Burg, S., Busch, C. -J., Bussmann, L., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Konig, D., Kopke, L. -G., Moeckelmann, N., Praetorius, M., Priemel, M., Stadlhofer, R., Stangenberg, M., Uzunoglu, F. G., Wittig, L., Zech, H., Zeller, N., Roux, F., Spaeth, T., Fricker, R., Muller, T., Schroder, L., Alasmari, M., Boeker, C., Hakami, I. A., Mall, J. W., Kyritsis, I., Graeb, C., Huber-Strossner, K., Branzan, D., Doss, M., Gockel, I., Jodicke, C., Osterhoff, G., Pempe, C., Sucher, R., Adler, T., Kelly, K., Merkle, J., Siebert, J., Hirche, C., Kneser, U., Tapking, C., Agrawal, R., Qureischie, H., Croner, R., Koslowski, L., Krause, H., Meyer, F., Turial, S., Al-Nawas, B., Battista, M. J., Goedeke, J., Hasenburg, A., Heider, J., Mueller, L. K., Zeller, S., Jentschura, S. L. P., Kowalewski, K. -F., Kriegmair, M., Mannle, D., Reissfelder, C., Rotter, N., Scherl, C., Seyfried, S., Kirschniak, A., Rolinger, J., Wilhelm, P., Bader, F. G., Ottl, S., Behr, A. V., Diamantis, A., Fichter, A., Grill, F., Heck, M., Jira, D., Kallmayer, M., Koll, F., Luhne, S., Meyer, B., Patachia, R., Pergolini, I., Safi, S., Schaffer, C., Schirren, M., Wegmann, H., Wirth, M., Zhu, Z., Aghamaliyev, U., Almaghrabi, M., Bocker, W., Bruder, J., Frank, K., Herterich, V., Huber, V., Ilmer, M., Kammerlander, C., Neuerburg, C., von Ehrlich-Treuenstatt, V. H., Werner, J., Borner, N., Fegg, F., Hartmann, D., Ladurner, R., Liokatis, P., Patzer, K., Schlager, J. G., Smolka, W., Zimmermann, P., Hatz, R., Steinhart, D., Glowalla, C., Schneidmueller, D., Henkel, K. W., Steiner, M., Holz, K., Knorr, C., Kuehlmann, B., Oikonomou, K., Prantl, L., Flurschutz, R., Honarpisheh, H., Kroger, M., Lepiorz, D., Luths, C., Niemeier, A., Sras, Y., Strate, T., Winter, T., Freiman, T., Gessler, F., Won, S. -Y., Widyaningsih, R., Hoffmann, S., Schafer, R. C., Thiel, J. T., Bertolani, E., Steidle, C., Uberruck, L., Yurttas, C., Ziegler, P., Zimmermann, A., Bolenz, C., Dayan, D., Greve, J., Hoffmann, T. K., Janni, W., Lobig, N., Schochter, F., Vahl, J. M., Wezel, F., Greif, V., Schmidbauer, S., Marsch, I., Schneider, R., Boenicke, L., Degener, S., Dreger, N. M., Horstmeier, F. C., Kruschwitz, J., Rombach, A., Schmidt, N., Seiberth, R., Singh, J., Smit, M., von Rundstedt, F. -C., Zirngibl, H., Diessner, J., Friedrich, S., Germer, C. -T., Helmer, P., Herrmann, J., Kranke, P., Kubler, H., Lock, J., Lotz, C., Meffert, R., Meybohm, P., Muller, S., Notz, Q., Popp, M., Schlegel, N., Schlesinger, T., Schmid, B., Sitter, M., Steinisch, A., Treutlein, A., van den Berg, A., Wurmb, T. E., Agyeman-Duah, N. K., Appiah, E., Armah, R., Asare, C., Awere-Kyere, L., Daary, D., Gakpetor, D., Allah, S. M., Obbeng, A., Osei-Poku, D., Puozaa, D., Tackie, E., Adu-Aryee, N. A., Agboadoh, N., Asare, O., Bowan, A. B., Brown, G. D., Clegg-Lamptey, J. -N., Dedey, F., Dery, C., Fenu, B. S., Harrison, M. A., Kumassah, P., Kuuzie, E., Nsaful, J., Olayiwola, D. O., Smith, C., Banka, C., Hussey, R., Azize, D. A., Aniakwo, L. A., Adofo-Asamoah, Y., Agbeno, E. K., Agyapong, M. M., Agyen, T., Mensah, K. A., Alhassan, B. A. B., Amoako-Boateng, M., Appiah-Thompson, P., Gyimah, N. A. -M., Asante-Bremang, M., Asante-Asamani, A., Atawurah, H., Appiah, A. B., Baidoo, R. O., Baidoo, E. I., Boakye, B., Boateng, A., Dadoe, D., Dayie, M. S. C. -J. K., Debrah, S., Doku, K., Enti, E., Ken-Amoah, S., Koggoh, P., Kpangkpari, R., Maison, P., Mensah, S., Mensah, P., Mensah, T. A., Morna, M. T., Nimako-Mensah, J., Nkrumah, J., Nortey, M., Ofori, E. O., Opandoh, I. N. M., Osei-Tutu, E., Adae, J. O., Quansah, K., Quartson, E., Rahman, G. A., Walawah, D., Yigah, M., Yussif, S., Jiagge, N., Nachelleh, E., Acquaye, J., Agbedinu, K., Agyei, F., Agyemang-Prempeh, A., Amo-Antwi, K., Amoah, M., Amoah, G., Amoako, Y. A., Aning, D. G., Ankobea-Kokroe, F., Mintah, D. A., Anyitey-Kokor, D., Appiah-kubi, A., Arthur, J., Ativor, V., Barnor, I., Braimah, Y., Darko-Asante, R., Davor, A., Issahalq, M. D., Dzogbefia, M., Emile, T., Fiifi-Yankson, P., Gaveh, V., Gudugbe, S., Gyabaah, S., Gyamfi, F. E., Gyedu, A., Gyimah, D., Hammond, B., Jonathan, B. -Y., Joseph, Y., Konney, T. O., Konney, A., Kusi, K., Kyei, I., Lovi, A., Naabo, N., Nimako, B., Nyadu, B., Nyarko, O. O., Ofosu-Barko, B. B., Oppong, P. P., Osabutey, A., Poku, M., Sagoe, R., Yifieyeh, A., Ansong, G., Abass, A., Abdul-Mumin, A., Adjeso, T., Alatiiga, J. A., Amadu, M., Annan, N., Leal, G. A., Bukari, M., Buunaaim, A., Cheyuo, E., Salifu, L. D., Damah, M., Dery, M., Dzantor, E. K., Garcia, O. G., Baba, Y. I., Issaka, A., Muntaka, A. -J. M., Murphy, J., Agyeman, Y. N., Amankwaa, W. O., Osman, I., Pie, S., Seidu, A. S., Sheriff, M., Charadan, A. M. S., Titigah, A., Yahaya, M., Yakubu, M., Yenli, E. M. T. -A., Grypiotis, I., Kiriakopoulos, N., Koliopoulos, G., Kyvelos, V., Micha, G., Papadopoulou, T., Balalis, D., Fradelos, E., Korkolis, D., Alexakis, N., Angelou, K., Haidopoulos, D., Prodromidou, A., Rodolakis, A., Thomakos, N., Psychogios, D., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Dimitra, P., Fragkoulidis, G., Gkiokas, G., Gklavas, A., Hadjizacharias, T., Karageorgou, D., Konstadoulakis, M., Kontopoulou, C., Massaras, D., Memos, N., Papaconstantinou, I., Politis, D., Polydorou, A., Stamatis, K., Theodosopoulos, T., Vezakis, A., Avgerinos, K., Katunin, J., Kechagias, A., Kelgiorgi, D., Kritikos, N., Pengerma, P., Bisdas, T., Ioannidis, A., Konstantinidis, M., Konstantinidou, S., Patelis, N., Antonopoulou, M. I., Deskou, E., Kalles, V., Manatakis, D. K., Stamos, N., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Frountzas, M., Kokoropoulos, P., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Vassiliu, P., Paraskevas, K. I., Bartziotas, D., Bouchagier, K., Galanis, I., Kalamatianos, T., Kapiris, S., Kolinioti, A., Mavrodimitraki, E., Metaxas, P., Nikova, A., Psarologos, M., Sotiropoulou, M., Stranjalis, G., Albanopoulos, K., Kondilis, P., Vrakopoulou, G. Z., Chrysovergis, A., Chrysovitsiotis, G., Giotakis, E., Kanellopoulou, V., Kyrodimos, E., Larentzakis, A., Pantos, P., Papanikolaou, V., Potamianos, S., Theodoropoulos, C., Triantafyllou, A., Triantafyllou, T., Georgousi, K., Panagiotou, P., Avramidis, E., Babis, G., Zafeiris, E., Antoniou, A., Bessias, N., Maras, D., Papas, T., Roditis, K., Tsagkos, I., Tsiantoula, P., Alexandrou, A., Baili, E., Charalabopoulos, A., Dimitroulis, D., Dorovinis, P., Garoufalia, Z., Kanavidis, P., Karavokyros, I., Karydakis, L., Kykalos, S., Kyros, E., Machairas, N., Mastoraki, A., Nikiteas, N., Papalampros, A., Schizas, D., Skotsimara, A., Stamopoulos, P., Syllaios, A., Terras, A., Tomara, N., Tsourouflis, G., Vagios, I., Zografos, C., Apostolou, K., Georgopoulos, N., Antoniou, T., Antzaka, C., Falara, A., Fragoulis, S., Ftikos, P., Matsouka, F., Perreas, K., Rellia, P., Samara, E., Smirli, A., Tasouli, A., Thanopoulos, A., Chalkias, P. L., Dedemadi, G., Mourmouris, P., Skolarikos, A., Theochari, N., Tzelves, L., Gaitanakis, S., Milas, T., Theodorakis, E., Karona, P., Kastanaki, P., Tzouganakis, A., Agalianos, C., Tsouknidas, I., Xenakis, A., Chrysos, E., Lasithiotakis, K., Nikolouzakis, T., Xenaki, S., Xynos, E., Lostoridis, E., Nagorni, E. -A., Pujante, A., Tourountzi, P., Al, A., Baxevanidou, K., Bouliaris, K., Efthimiou, M., Kalfountzos, C., Koukoulis, G., Lachanas, V., Petropoulos, K., Tsitiridis, I., Angelis, F., Arnaoutoglou, E., Baloyiannis, I., Bareka, M., Bouronikou, A., Christodoulidis, G., Daponte, A., Fergadi, M., Gkolias, N., Gkrinia, E., Hajiioannou, J., Kalogritsas, N., Karoni, E., Korais, C., Krestinidis, G., Ktisti, A., Magouliotis, D., Maiou, C., Malizos, K., Minasidou, M., Ntalouka, M., Ntziovara, A. M., Palla, E., Perivoliotis, K., Saini, F., Samara, A., Saratziotis, A., Skoulakis, C., Solomi, E., Stamoulis, K., Terzoudis, C. D., Tsironi, E., Tzovaras, G., Vallianou, K., Zacharoulis, D., Ziogkou, A., Elias, L., Maroulis, I., Mulita, F., Plachouri, K. -M., Vailas, M., Doitsidis, C., Filo, E., Gkalonaki, I., Kogia, E., Kontopoulou, K., Mitroudi, M., Panteli, C., Patoulias, I., Semkoglou, O. I., Sfoungaris, D., Valioulis, I., Astreidis, I., Christidis, P., Ioannidis, O., Loutzidou, L., Mantevas, A., Paraskevopoulos, K., Tatsis, D., Athanasiadis, A., Dagklis, T., Kalogiannidis, I., Kapetanios, G., Mamopoulos, A., Margioula-Siarkou, C., Petousis, S., Tsakiridis, I., Anthoulakis, C., Christou, C., Fantakis, A., Iordanidou, E., Kaselas, C., Panagiotidou, S., Papadopoulos, V., Papavasiliou, K., Piachas, A., Siasios, I., Spyridakis, I., Theodoridis, T., Tooulias, A., Tsiridis, E., Tsopozidi, M., Aleman, M., Brolo, E., Lemus, A. L., Greenberg, J., Chew, K. M. M., Oliva, J. R., Lima, M. A. D. L., Muralles, I. L., Solares, F., Ajcip, G., Anton, C., Cojulun, J., Flores, M. -A., Jose, N., Paiz, C. A. M., Morales, S., Najera, R., Lorenzana, E. Q., Rivera, P., Rodas, L., Santos, V., Sosa, D., Ybarra, N., Cajti, J. D. P., Regil, C., Osorio, W. A., Arriola, R. R., Tale-Rosales, L. -F., Herrera, D., Rodriguez, S. T. T., Villeda, S. A., Anicetti, J., Medina, A. M. L., Ardebol, J., Barillas, K., De Leon, F., Recinos, S., Marroquin-Alpirez, M. -A., Yax, Y., Hon, S., Liu, Y. H., Liu, A. Q., Liu, S., Chiu, H. T. N., Chow, C. M. T., Hau, V., Ip, H. W., Mak, B., Mok, C. Y., Ng, D., Siu, Y. Y. E., Wong, K. F., Pu, J. J., Su, Y. -X., Au-Yeung, K. Y., Chan, D. Y. C., Chan, A., Chan, S. M., Chang, T. C., Chiu, T. W., Chiu, W. K., He, Z., Ho, M. F., Ho, K. K. W., Ho, J. Y. K., Kung, J. W. C., Lam, C. H., Lau, R. W. H., Ling, S. K. K., Lok, H. T., Mak, T. W. C., Ng, C. -F., Ng, S., Ng, K. K. -C., Ng, C. S. H., Ong, M. T. Y., Tan, T., Tang, S. F., Teoh, J. Y. -C., Teoh, A., Tsui, B. S. Y., Wong, G. K. C., Wong, R., Wong, K. C., Yee, C. H., Antal, Z., Kalman, A., Voros, P., Bahrehmand, K., Echim, T., Novak, Z., Sztipits, T., Bihari, L. A., Hidi, L., Piros, L., Rozsa, B., Sotonyi, P., Szatai, L., Herczeg, G., Pordany, B., Tornyi, F., Dede, K., Egyed, T., Saftics, G., Kulcsicka-Gut, J., Sipos, Z., Toth, D., Patel, B., Majmudar, H., Mankad, S., Pathan, S., Sharathkumarkl, L., Sasatti, L., Mahankali, S., Annayappa, S. K. S., Agrawal, T., Anandan, P., Baindur, A., Bd, M., Savitha, C., Anitha, G. S., Harigond, S., Tejeswini, K. K., Kesarla, V., Manangi, M., Hareesh, P. B., Ranjan, J. K. R., Shetty, A., Chikkanayakanahalli, S. S., Sunil, T., Syamala, S., Tharanath, K., Atal, A., Rajagopal, N., Srinath, B. S., Nk, V., Thirumanikandan, P. L., Mishra, N., Shrivastava, S., Wadhwani, R., Ahmad, R., Haq, Z. A., Behera, P., Dhurwe, R., Haq, R., Jain, V., Karna, S., Pushpalatha, K., Raj, S., Santoshi, J. A., Singh, P., Verma, V., Waindeskar, V., Yadav, M. S., Aziz, Z., Chakraborty, K., Chappity, P., Das, G., Datta, D., Jena, S. K., Kar, M., Khuntia, S., Kumar, P., Kumar, R., Kv, A., Mishra, A., Mishra, S., Mittal, Y., Muduly, D., Panda, R., Panigrahi, S., Parija, S., Patra, S., Rout, B., Sahu, R., Sarkar, S., Singh, S., Sudha, S., Sultania, M., Tripathy, S., Varghese, P., Kansay, R., Kaushik, R., Gupta, S. K., Khare, S., Kumar, V., Mohindra, S., Patil, N., Salunke, P., Savlania, A., Singh, K., Pradeep Krishna, R. V., Narasimhan, G., Rela, M., Appukuttan, A., Goudar, S., Mallick, S., Titus, C., Chidambarasamy, E. S., Madhavan, D., Murugesan, A., Narayanasamy, K., Barani Kumar, P. B., Rajan, F., Vijayaragavan, P., Borthakur, B., Chauhan, T. S., Govil, A., Hanjoora, V. M., Srivastava, A., Tiwari, S., Vishwani, V., Pendyala, K. S., Prasad, N., Bothra, J., Deb, M., Herle, K., Jayaram, H., Kannaiyan, L., Krithiga, A., Mukta, W., Nagpal, P., Pathak, P., Banerjee, S., Chaudhary, R., Choudhary, G. R., Chugh, A., Dixit, P., Elhence, A., Gahlot, N., Garg, M., Ghuman, N. K., Jha, D., Kala, P., Kaur, A., Madduri, V., Pandey, H., Pareek, P., Pathak, M., Rathod, K. J., Rodha, M. S., Saxena, R., Sharma, N., Shekhar, S., Singh, M., Suryanarayanan, B., Vishnoi, J. R., Amin, S., Sharma, T., Murugesan, K., Ramasamy, A. B. S., Chatterjee, D., Gerber, C. G., Naskar, U., Aggarwal, G., Agrawal, S. K., Jain, P., Jain, D., Kewlani, V., Pipara, A., Priya, N., Raja, R., Shakya, S., Thambudorai, R., Kharkongor, D., Akhtar, N., Anand, A., Asnani, M., Chaturvedi, A., Chaurasia, A., Enny, L. E., Garg, S., Jaiswal, A. K., Jaiswal, S., Jaware, Y., Kala, N., Karnatak, R., Kumar, U., Shrivastava, A. K., Mehrotra, S., Mishra, B., Namrata, Ojha, B. K., Ozair, A., Pal, U. S., Pandey, A., Raja, N., Ramakant, P., Roy, A., Sachan, R., Sankhwar, S., Sankhwar, P., Sarin, D., Shukla, A., Singh, K. R., Singh, R., Singh, U., Solanki, V., Sonkar, A. A., Srivastava, C., Suryawanshi, P., Tewarson, V., Verma, R., Verma, M. L., Yadav, A., Chand, G., Chanthar, K. M. M. V., Hoysal, D., Batra, N., Bhatti, A., Chopra, R., David, S., Dhar, T., Dutt, U. K., Dutta, R., Gandhi, S., Haque, P. D., Paul Sudhakar John, B., Veetil, S. K., Kaur, G., Kumar, N., Luther, A., Mahajan, A., Mandrelle, K., Mathews, S., Michael, V., Mukherjee, P., Pargal, P., Paul, R., Phillip, A., Phillips, R., Samuel, A., Singh, N., Singh, I., Singh, A., Grewal, S. S., Singhania, A., Thirumalai, S., Varghese, A., Wesley, J., Thomas, J., Zechariah, P., Ifthikar, M. A., Mathew, R. T., Shetty, R., Vijaykumar, M. V., Hameed, B. M. Z., Ibrahim, S., Jyothish, G., Krishna, S., Mathew, S., Kumar, A. S., Sinha, P. K., Sridhar, R., Agarwal, S., Balasubramaniam, S., Chhatrapati, S., Deshpande, C., Dharia, A., Fernandes, S., Gore, M., Jayakumar, A., Mhamane, R., Nirgude, A., Parab, S., Patil, M., Peswani, A., Sahu, A., Samel, S., Shah, F., Haridas, D., Shetty, V., Abraham, B., Agarwal, V., Ahmad, Q., Asari, A., Attar, M. I., Ayyalasomayajula, N. S., Bachawat, S., Bachhav, S., Badhe, V., Badhwar, S., Basa, V. I. K. A. S., Bothara, V., Chattopadhyay, S., Chaudhari, S., Chavan, R., Chawathe, P., Dadhich, S., Dalal, A., Date, A., Deshpande, M., Dev, P., Dongre, N., Doshi, A., Gade, M., Gajjar, S., Gawande, M., Ghalme, A., Ghugare, B., Gupta, I., Jain, M., Jenasamant, S. S., Joshi, V., Kalwadia, N., Kapadia, N., Kattana, H. B. R., Kaushik, T., Kayal, A., Kovale, S., Kulkarni, Y., Kumar, K., Kumawat, K., Lad, V., Maskara, N., Mistry, R., Mohanty, S. R., Motwani, K., Mulchandani, M., Nadkarni, M., Pandey, S., Parab, M., Pardiwala, D., Patkar, A., Pawar, N., Pawar, A., Pednekar, A., Peshattiwar, V., Pokharkar, H., Potdar, O., Pothare, A., Rahmani, F., Rajput, S., Narendra, N. R., Rao, A., Rao, S., Rohela, H., Sakhrekar, R., Salunkhe, D., Sandlas, G., Sarkar, H., Satpathy, A., Sekhar, R., Shelke, Y., Shetty, S. S., Shetye, S., Kulkarni, A. S., Singal, U., Solanki, F., Sonawane, R., Thete, R., Vhatkar, R., Vora, S., Waigankar, S., Wasnik, S., Yadav, M., Yedave, R., Acharya, H., Bangar, A., Bharucha, M., Dhumane, P., Karmarkar, S., Nathani, R., Nehe, A., Nene, A., Noronha, W. J., Palapalle, N., Patel, P., Poyyil, D., Redkar, R., Shah, M., Tewari, S., Bakshi, G., Chaudhari, V., Deshmukh, A., Desoouza, A., Nair, D., Nayak, P., Patkar, S., Puri, A., Qureshi, S., Shetty, P., Shylasree, T., Thakkar, P., Thiagarajan, S., Tiwari, V. K., Voppuru, S. R., Soni, A., Soni, G., Alam, J., Bagaria, D., Bajpai, M., Bisoi, A. K., Chauhan, S., Choudhary, N., Chouhan, R. S., Chumber, S., Farooque, K., Gudala, V., Joshi, M., Kabra, A., Kale, S. S., Kumar, S., Mahajan, D., Malhotra, R., Menon, P. R., Misra, B., Mittal, S., Parshad, R., Priyadarshini, P., Sagar, S., Sharma, P. B., Sharma, V., Trikha, V., Tyagi, M., Bansal, K., Varma, K., Bhardwaj, R., Mittal, A., Ponnusamy, S., Singh, G. R., Tuli, I., Bhor, P., Dhar, S., Kale, S., Aggarwal, M., Gupta, H., Deshpande, A., Gadekar, A., Jaysingani, T., Panjwani, T., Patil, R., Vaidya, N., Vishwakarma, S. K., Wayal, U., Dutta, D., Arora, R., Dhingra, M., Garg, P. K., Huda, F., Kandwal, P., Kant, R., Seenivasagam, R. K., Joshua, L. M., Poonia, D. R., Rajput, D., Sadhasivam, S., Singh, V., Chandanwale, K., Philip, M., Thorat, V., Choudhury, Y., Das, D., Das, M., Goala, S., Laskar, F. Y., Laskar, P., Malik, K., Sarkar, A., Singha, S. T., Singha, M. N., Singha, D., Srungavarapu, G., Tapkire, R., Tling, S., Andrabi, S. M. I., Bhat, G. A., Chowdri, N., Kour, R., Parray, F., Shah, Z. A. M. I. R. A. H. M. A. D., Wani, R., Adamala, S., Gowder, R., Hegde, S., Mashitha, M. S., Sreeram, S., Ankadavar, S., Bafna, D., Dhanani, B., Ingle, N., Jadhao, P., Joseph, S., Kapote, S., Karkada, S., Lad, P., Lohia, R., Madje, S., Narasiman, V., Chisthi, M., George, G., Jothi, H., Pareed, D., Mathew, G. D. C., Abel, L., Agrawal, M., Rabindranath, B., Baldia, M., Barla, R. K., Beck, M., Benjamin, S., Bliss, J., Cherian, L., Devarakonda, S., Ete, G., George, A. J. P., Iovino, Claudio, CovidSurg Collaborarive, Frisoni T., Palmerini E., Donati D., Traina F., Solaini L., Pignatti M., Conti A., Internal Medicine, Collaborative, COVIDSurg, Collaborative, GlobalSurg, Apollo - University of Cambridge Repository, COVIDSurg Collaborative, Li, E, Emanuele Cammarata, Sofia Campanella, Daniela Canzonieri, Adriana Cordova, Federico De Michele, Ettore Dinoto, Mara Franza, Leo Licari, Daniele Matta, Domenico Mirabella, Felice Pecoraro, Roberto Pirrello, Pierfrancesco Pugliese, Fernando Rosatti, Giuseppe Salamone, Francesca Toia, Massimiliano Tripoli, Vito Chiantera, Leo Licari, Palmisano, Silvia, de Manzini, Nicolo', Collaborative, Covidsurg, Collaborative, Globalsurg, Faculty of Medicine and Pharmacy, Clinical sciences, Medical Oncology, Basic (bio-) Medical Sciences, Diabetes Pathology & Therapy, Gastroenterology, Fruscio, R, Ornaghi, S, Surgical clinical sciences, COVIDSurg Collaborative (GlobalSurg, Collaborative), Beretta, L, and Aldrighetti, L.
Subjects: Male, pulmonary embolism, Internationality, Settore MED/18 - CHIRURGIA GENERALE, Deep vein, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], infectious diseases, Cardiovascular, SARS‐CoV‐2, surgery, COVID-19, SARS-CoV-2, deep vein thrombosis, venous thromboembolism, Cohort Studies, Postoperative Complications, Anesthesiology, Medicine and Health Sciences, Prospective Studies, 610 Medicine & health, Prospective cohort study, Lung, 11 Medical and Health Sciences, Confounding, Hematology, Middle Aged, Thrombosis, 17 Psychology and Cognitive Sciences, Pulmonary embolism, medicine.anatomical_structure, Cohort, COVID-19/complications, Postoperative Complications/etiology, Original Article, Female, Patient Safety, Life Sciences & Biomedicine, Human, Adult, medicine.medical_specialty, Adolescent, Clinical Sciences, GlobalSurg Collaborative, Venous Thromboembolism/etiology, NO, COVIDSurg Collaborative, Young Adult, Medicine, General & Internal, Age Distribution, Clinical Research, COVID‐19, General & Internal Medicine, medicine, Humans, Sex Distribution, Aged, Science & Technology, business.industry, Prevention, Neurosciences, deep vein thrombosi, Pneumonia, Odds ratio, Original Articles, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Prospective Studie, Good Health and Well Being, Anesthesiology and Pain Medicine, Human medicine, Postoperative Complication, Cohort Studie, business, Venous thromboembolism, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly. ispartof: ANAESTHESIA vol:77 issue:1 pages:28-39 ispartof: location:England status: published
Published: 2022
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17. Versorgungsstrategien bei tumorbedingten pathologischen Frakturen der Extremitäten

Author: M Omar, Christian Krettek, M. Ettinger, N. Bruns, Christian von Falck, and Tilman Graulich
Subjects: medicine.medical_specialty, Osteosynthesis, Sports medicine, business.industry, Hand surgery, medicine.disease, Surgery, Prostate cancer, Plastic surgery, medicine.anatomical_structure, Emergency Medicine, medicine, Orthopedics and Sports Medicine, Humerus, Femur, Tibia, business
Abstract: Pathological fractures of the extremities frequently lead to uncertainty with respect to the treatment strategy and timing. The origin of metastases is typically breast, bronchial, renal and prostate cancer and myelomas. Primary bone tumors play a subordinate role. The majority affect the femur, humerus and occasionally the tibia. Surgery is typically the first line treatment as healing under conservative treatment is unlikely. The most important goal is to relieve pain and the preservation or restoration of function. For correct assessment of indications, analysis of the fracture pattern and oncological aspects including dignity, entity, prognosis, metastatic status and the general condition of the patient need to be taken into consideration. Based on all these aspects the surgical approach can be chosen. Treatment options range from osteosynthetic stabilization and augmentation osteosynthesis up to endoprosthesis replacement. The treatment is carried out in an interdisciplinary procedure as additional measures need to be addressed in addition to the surgical treatment.
Published: 2021
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18. Liver transplantation in malignant disease

Author: Ulf P. Neumann, Sven Arke Lang, Tony Bruns, Andreas Kroh, Pavel Strnad, Daniel Heise, Jan Bednarsch, Zoltan Czigany, Florian Ulmer, I. Amygdalos, and Katharina Joechle
Subjects: Oncology, medicine.medical_specialty, Hepatocellular carcinoma, medicine.medical_treatment, Review, Cholangiocellular carcinoma, Liver transplantation, Milan criteria, Undifferentiated embryonal sarcoma of the liver, Internal medicine, medicine, Stage (cooking), Neoadjuvant therapy, Intrahepatic Cholangiocarcinoma, business.industry, Cancer, medicine.disease, digestive system diseases, Transplantation, Neuroendocrine cancer liver metastases, Colorectal cancer liver metastases, Hepatic epithelioid hemangioendothelioma, business
Abstract: Liver transplantation for malignant disease has gained increasing attention as part of transplant oncology. Following the implementation of the Milan criteria, hepatocellular carcinoma (HCC) was the first generally accepted indication for transplantation in patients with cancer. Subsequently, more liberal criteria for HCC have been developed, and research on this topic is still ongoing. The evident success of liver transplantation for HCC has led to the attempt to extend its indication to other malignancies. Regarding perihilar cholangiocarcinoma, more and more evidence supports the use of liver transplantation, especially after neoadjuvant therapy. In addition, some data also show a benefit for selected patients with very early stage intrahepatic cholangiocarcinoma. Hepatic epithelioid hemangioendothelioma is a very rare but nonetheless established indication for liver transplantation in primary liver cancer. In contrast, patients with hepatic angiosarcoma are currently not considered to be optimal candidates. In secondary liver tumors, neuroendocrine cancer liver metastases are an accepted but comparability rare indication for liver transplantation. Recently, some evidence has been published supporting the use of liver transplantation even for colorectal liver metastases. This review summarizes the current evidence for liver transplantation for primary and secondary liver cancer.
Published: 2021
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19. Predictive factors for vaccine failure to guide vaccination in allogeneic hematopoietic stem cell transplant recipients

Author: Anke H W Bruns, Jürgen Kuball, Roel J de Weijer, Nening M. Nanlohy, Debbie van Baarle, Gaby Smits, Michelle J M Janssen, Frans M. Verduyn Lunel, and Reinier A P Raijmakers
Subjects: Transplantation, Vaccination schedule, business.industry, Tetanus, Diphtheria, medicine.medical_treatment, Context (language use), Hematology, Hematopoietic stem cell transplantation, medicine.disease, Vaccination, Immune system, Immunology, medicine, business, Vaccine failure
Abstract: Vaccination after hematopoietic stem cell transplantation (HSCT) is essential to protect high-risk patients against potentially lethal infections. Though multiple studies have evaluated vaccine specific responses, no comprehensive analysis of a complete vaccination schedule post-HSCT has been performed and little is known about predictors for vaccine failure. In this context, allogeneic HSCT (alloHSCT) patients were included and vaccinated starting one year post-transplantation. Antibody responses were measured by Multiplex Immuno Assay for pneumococcal (PCV13), meningococcal C, diphtheria, pertussis, tetanus and Haemophilus influenza type b one month after the last vaccination and correlated to clinical and immunological parameters. Vaccine failure was defined as antibody response above vaccine-specific cut-off values for less than four out of six vaccines. Ninety-six patients were included of which 27.1% was found to have vaccine failure. Only 40.6% of all patients responded adequately to all six vaccines. In multivariate analysis, viral reactivation post-HSCT (OR 6.53; P = 0.03), B-cells
Published: 2021
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20. Short-term outcome of Ivor Lewis esophagectomy following neoadjuvant chemoradiation versus perioperative chemotherapy in patients with locally advanced adenocarcinoma of the esophagus and gastroesophageal junction: a propensity score-matched analysis

Author: Angela Ernst, Lars Schiffmann, Wolfgang Schröder, Christiane J. Bruns, Patrick Sven Plum, Marc Bludau, Alexander Damanakis, Hans F. Fuchs, Hakan Alakus, Rabi R Datta, Arnulf H. Hölscher, Lisa Buschmann, Seung-Hun Chon, and Thomas Zander
Subjects: Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Adenocarcinoma, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Clinical endpoint, Humans, Esophagus, Propensity Score, Survival rate, Retrospective Studies, Chemotherapy, Gastric emptying, business.industry, Multimodal therapy, Chemoradiotherapy, General Medicine, medicine.disease, Neoadjuvant Therapy, Esophagectomy, Treatment Outcome, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Propensity score matching, 030211 gastroenterology & hepatology, Esophagogastric Junction, business
Abstract: Background Patients with locally advanced esophageal or gastroesophageal adenocarcinoma benefit from multimodal therapy concepts including neoadjuvant chemoradiation (nCRT), respectively, perioperative chemotherapy (pCT). However, it remains unclear which treatment is superior concerning postoperative morbidity. Methods In this study, we compared the postsurgical survival (30-day/90-day/1-year mortality) (primary endpoint), treatment response, and surgical complications (secondary endpoints) of patients who either received nCRT (CROSS protocol) or pCT (FLOT protocol) due to esophageal/gastroesophageal adenocarcinoma. Between January 2013 and December 2017, 873 patients underwent Ivor Lewis esophagectomy in our high-volume center. 339 patients received nCRT and 97 underwent pCT. After 1:1 propensity score matching (matching criteria: sex, age, BMI, ASA score, and Charlson score), 97 patients per subgroup were included for analysis. Results After matching, tumor response (ypT/ypN) did not differ significantly between nCRT and pCT (p = 0.118, respectively, p = 0.174). Residual nodal metastasis occurred more often after pCT (p = 0.001). Postsurgical mortality was comparable within both groups. No patient died within 30 or 90 days after surgery while the 1-year survival rate was 72.2% for nCRT and 68.0% for pCT (p = 0.47). Only grade 3a complications according to Clavien–Dindo were increased after pCT (p = 0.04). There was a trend towards a higher rate of pylorospasm within the pCT group (nCRT: 23.7% versus pCT: 37.1%) (p = 0.061). Multivariate analysis identified pCT, younger age, and Charlson score as independent variables for pylorospasm. Conclusion Both nCRT and pCT are safe and efficient within the multimodal treatment of esophageal/gastroesophageal adenocarcinoma. We did not observe differences in postoperative morbidity. However, functional aspects such as gastric emptying might be more frequent after pCT.
Published: 2021
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21. CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

Author: Michael von Bergwelt-Baildon, Axel Lechner, Florian Klein, Maria Garcia-Marquez, Kerstin Wennhold, Ella Preugszat, Simon Schran, Meryem S. Ercanoglu, Alexander Quaas, Sebastian Eidt, Heike Löser, J Lehmann, Christiane J. Bruns, Alexander Shimabukuro-Vornhagen, Hans A. Schlößer, Fabinshy Thangarajah, and Martin Thelen
Subjects: CD86, Cancer Research, Tumor microenvironment, biology, T cell, Immunology, Cancer, medicine.disease, Peripheral blood mononuclear cell, medicine.anatomical_structure, Antigen, medicine, biology.protein, Cancer research, Cancer/testis antigens, Antibody
Abstract: The role of B cells in antitumor immunity and their impact on emerging immunotherapies is increasingly gaining attention. B-cell effector functions include not only secretion of antibodies, but also presentation of antigens to T cells. A physiologic B-cell subset with immunostimulatory properties was described in humans, defined by a high expression of CD86 and downregulation of CD21. We used multicolor flow cytometry and IHC to elucidate abundance and spatial distribution of these antigen-presenting B cells (BAPC) in blood (peripheral blood mononuclear cells, PBMC) and tumor samples of 237 patients with cancer. Antigen-specific T-cell responses to cancer testis antigens were determined using tetramer staining and sorted BAPCs in FluoroSpot assays for selected patients. We found that BAPCs were increased in the tumor microenvironment of 9 of 10 analyzed cancer types with site-specific variation. BAPCs were not increased in renal cell carcinoma, whereas we found a systemic increase with elevated fractions in tumor-infiltrating lymphocytes (TIL) and PBMCs of patients with colorectal cancer and gastroesophageal adenocarcinoma. BAPCs were localized in lymphoid follicles of tertiary lymphoid structures (TLS) and were enriched in tumors with increased numbers of TLSs. BAPCs isolated from tumor-draining lymph nodes of patients with cancer showed increased percentages of tumor antigen–specific B cells and induced responses of autologous T cells in vitro. Our results highlight the relevance of BAPCs as professional antigen-presenting cells in tumor immunity and provide a mechanistic rationale for the observed correlation of B-cell abundance and response to immune checkpoint inhibition.
Published: 2021
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22. Knowledge and Attitudes Toward Renal Transplantation in Individuals Undergoing Transplant Evaluation

Author: Deonna R. Moore, Patricia Elizabeth Davies Hall, Cassandra Bruns, David Phillippi, and Jeannie Giese
Subjects: Program evaluation, Health Knowledge, Attitudes, Practice, Transplantation, medicine.medical_specialty, business.industry, medicine.disease, Kidney Transplantation, Kidney transplant, End stage renal disease, Renal transplant, Surveys and Questionnaires, medicine, Humans, Kidney Failure, Chronic, Lack of knowledge, Intensive care medicine, business, Kidney disease
Abstract: Introduction: The underutilization of kidney transplant as the preferred treatment for end-stage kidney disease is influenced by a lack of knowledge, poor attitudes, and various socio-demographic characteristics. Negative attitudes toward renal transplant disengage patients from the evaluation process and often hinder their likelihood of receiving a transplant. Purpose: Determine whether a standardized educational session successfully improves knowledge and attitudes toward kidney transplant. Explore which socio-demographic variables are associated with more negative baseline attitude scores. Design: The program evaluation utilized a pre-test/post-test design to assess attitudes and knowledge toward renal transplant before and after an educational session. The pre- and post-surveys were distributed to a convenience sample of 341 and 115 patients, respectively, between the months of September and December 2019. Results: Exposure to a kidney transplant education program resulted in greater levels of knowledge ( P = 0.019, d = 0.334). Individuals with no college education were found to have more negative baseline attitudes toward renal transplantation ( P = 0.048, d = 0.382). Conclusion: More research is needed to explore how knowledge, attitudes, and certain socio-demographic characteristics impact a patient’s intention to pursue kidney transplant. Uncovering reasons as to why certain populations of individuals have more negative baseline attitudes toward kidney transplant may also provide clinicians and transplant programs with valuable information on how pre-transplant education can be tailored to meet the needs of specific populations.
Published: 2021
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23. Der Stellenwert der Thymektomie ohne Thymom in der Therapie der Myasthenia gravis

Author: Thorsten Wahlers, Michael Schroeter, Fabian Doerr, Hruy Menghesha, Christiane J. Bruns, Georg Schlachtenberger, Khosro Hekmat, Costanza Chiapponi, and Matthias Heldwein
Subjects: medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, Minimally invasive treatment, 03 medical and health sciences, 0302 clinical medicine, Transplant surgery, Kausale Therapie, Myasthenia Gravis, medicine, Humans, Acetylcholine receptor, Randomized Controlled Trials as Topic, Retrospective Studies, Gynecology, business.industry, Acetylcholin-Rezeptor, Thoracic Surgery, Video-Assisted, Übersichten, Subgroups, Subgruppen, medicine.disease, Thymectomy, Sternotomy, Myasthenia gravis, Treatment Outcome, Roboterassistierte Thymektomie, Cardiothoracic surgery, Minimal-invasive Therapie, Surgery, Causal treatment, business, 030217 neurology & neurosurgery, Robotic-assisted thymectomy
Abstract: The value of thymectomy in the treatment of non-thymomatous myasthenia gravis has been controversially discussed. The relatively low incidence and prevalence of this disease, the inconsistent documentation in various studies and the necessity of a long-term follow-up to assess the therapeutic effects has made the generation of valid data difficult. The publication in 2016 of the MGTX trial in the New England Journal of Medicine delivered the first randomized controlled data in which patients aged 18-65 years with generalized myasthenia gravis and positive for acetylcholine receptor antibodies showed a significant benefit after surgical resection of the thymus via median sternotomy. Despite a lack of validation of the advantages of thymectomy by minimally invasive surgery from randomized controlled studies, this technique seems to positively influence the outcome of certain patient groups in a similar way. Video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracic surgery (RATS) using subxyphoidal and transcervical access routes showed not only esthetic advantages but also showed no relevant inferiority in the influence on clinical outcomes of myasthenia gravis compared to median sternotomy; however, not only the benefits and the esthetic results show differences but also the advantages in the various subtypes of myasthenia gravis show divergent prospects of success with respect to remission. The clinical spectrum of myasthenia is heterogeneous with respect to the occurrence of antibodies, the body region affected and the age of the patient at first diagnosis. Ultimately, thymectomy is an effective causal treatment of myasthenia gravis.Der Stellenwert der Thymektomie in der Therapie der thymomfreien Myasthenia gravis blieb bis vor einiger Zeit umstritten. Die relativ geringe Inzidenz und Prävalenz der Erkrankung, die uneinheitliche Dokumentation in den verschiedenen Studien sowie die notwendige Langzeitbeobachtung zur Erfassung therapeutischer Effekte erschwerten das Generieren valider Daten. Die Veröffentlichung des MGTX-Trials 2016 im New England Journal of Medicine lieferte die ersten randomisiert-kontrollierten Daten, nach denen Patienten mit Acetylcholin-Rezeptor-Antikörper-positiver generalisierter Myasthenia gravis im Alter von 18 bis 65 Jahren von der chirurgischen Resektion des Thymus über eine mediane Sternotomie profitieren. Trotz fehlender Validierung des Vorteils der Thymektomie über minimal-invasive Techniken durch randomisiert-kontrollierte Studien scheinen diese das Outcome bestimmter Patientengruppen in ähnlicher Form positiv zu beeinflussen. So haben videoassistiert-thorakoskopische, roboterassistierte, subxiphoidale und transzervikale Zugangswege nicht nur ästhetische Vorteile, sondern zeigen in der Beeinflussung des Krankheitsverlaufs der Myasthenia gravis keine relevante Unterlegenheit gegenüber der medianen Sternotomie. Doch nicht nur der Nutzen und das ästhetische Ergebnis differieren, sondern auch die Erfolgsaussichten im Hinblick auf die Remission sind bei den Unterformen der Myasthenia gravis unterschiedlich. Die heterogene Gruppe der Myasthenien unterscheidet sich bezüglich des Auftretens von Autoantikörpern, der betroffenen Körperregionen und des Alters der Patienten bei Erstdiagnose. Schließlich ist die Thymektomie eine wirksame kausale Therapie der Myasthenia gravis.
Published: 2021

24. Endoscopic vacuum therapy versus stent treatment of esophageal anastomotic leaks (ESOLEAK): study protocol for a prospective randomized phase 2 trial

Author: Jakob R. Izbicki, Isabel Rieck, Tobias Goeser, Christiane Bruns, Seung-Hun Chon, Thomas Rösch, Florian Gebauer, Hildegard Christ, Marcus Kantowski, Karl Karstens, and Michael Tachezy
Subjects: Adult, medicine.medical_specialty, Leak, Medicine (General), Esophageal Neoplasms, medicine.medical_treatment, Esophageal cancer, Medicine (miscellaneous), Anastomotic Leak, Pilot Projects, Anastomosis, law.invention, 03 medical and health sciences, Study Protocol, 0302 clinical medicine, Clinical Trials, Phase II as Topic, R5-920, Randomized controlled trial, Meta-Analysis as Topic, law, medicine, Clinical endpoint, Humans, Pharmacology (medical), Prospective Studies, Anastomotic leaks, Randomized Controlled Trials as Topic, Retrospective Studies, medicine.diagnostic_test, business.industry, Endoscopic vacuum therapy, Stent, Endoscopy, medicine.disease, Self-expanding metal stents, Surgery, Esophagectomy, Treatment Outcome, 030220 oncology & carcinogenesis, Quality of Life, 030211 gastroenterology & hepatology, Stents, business, Interventional endoscopy, Negative-Pressure Wound Therapy
Abstract: Background Intrathoracic anastomotic leaks represent a major complication after Ivor Lewis esophagectomy. There are two promising endoscopic treatment strategies in the case of leaks: the placement of self-expanding metal stents (SEMS) or endoscopic vacuum therapy (EVT). Up to date, there is no prospective data concerning the optimal endoscopic treatment strategy. This is a protocol description for the ESOLEAK trial, which is a first small phase 2 randomized trial evaluating the quality of life after treatment of anastomotic leaks by either SEMS placement or EVT. Methods This phase 2 randomized trial will be conducted at two German tertiary medical centers and include a total of 40 patients within 2 years. Adult patients with histologically confirmed esophageal cancer, who have undergone Ivor Lewis esophagectomy and show an esophagogastric anastomotic leak on endoscopy or present with typical clinical signs linked to an anastomotic leak, will be included in our study taking into consideration the exclusion criteria. After endoscopic verification of the anastomotic leak, patients will be randomized in a 1:1 ratio into two treatment groups. The intervention group will receive EVT whereas the control group will be treated with SEMS. The primary endpoint of this study is the subjective quality of life assessed by the patient using a systematic and validated questionnaire (EORTC QLQ C30, EORTC QLQ-OES18 questionnaire). Important secondary endpoints are healing rate, period of hospitalization, treatment-related complications, and overall mortality. Discussion The latest meta-analysis comparing implantation of SEMS with EVT in the treatment of esophageal anastomotic leaks suggested a higher success rate for EVT. The ESOLEAK trial is the first study comparing both treatments in a prospective manner. The aim of the trial is to find suitable endpoints for the treatment of anastomotic leaks as well as to enable an adequate sample size calculation and evaluate the feasibility of future interventional trials. Due to the exploratory design of this pilot study, the sample size is too small to answer the question, whether EVT or SEMS implantation represents the superior treatment strategy. Trial registration ClinicalTrials.gov NCT03962244. Registered on May 23, 2019. DRKS-ID DRKS00007941
Published: 2021

25. Reply to: 'G-CSF in acute-on-chronic liver failure – Art of ‘patient selection’ is paramount!'

Author: C Engelmann, Tony Bruns, and Thomas Berg
Subjects: Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Patient Selection, Acute-On-Chronic Liver Failure, medicine.disease, Severity of Illness Index, Gastroenterology, Internal medicine, Granulocyte Colony-Stimulating Factor, Humans, Medicine, Acute on chronic liver failure, business, Selection (genetic algorithm)
Published: 2022
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26. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Author: Rodolfo Citro, Jelena R. Ghadri, Guido Grassi, Liam Couch, Eduardo Bossone, Thomas Thum, Guido Parodi, Bastian Bruns, Christian Templin, Stephane Heymans, Ovidiu Chioncel, Elmir Omerovic, Birke Schneider, Jolanda van der Velden, C. Gabriele Tocchetti, Dana Dawson, Massimo Iacoviello, Johannes Backs, Alexander R. Lyon, Michele Ciccarelli, Björn Redfors, Omerovic, E., Citro, R., Bossone, E., Redfors, B., Backs, J., Bruns, B., Ciccarelli, M., Couch, L. S., Dawson, D., Grassi, G., Iacoviello, M., Parodi, G., Schneider, B., Templin, C., Ghadri, J. R., Thum, T., Chioncel, O., Tocchetti, C. G., Van Der Velden, J., Heymans, S., Lyon, A. R., Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy, Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, Van Der Velden, J, Heymans, S, Lyon, A, University of Zurich, Omerovic, Elmir, and Lyon, Alexander R
Subjects: Nervous system, Sympathetic nervous system, Cardiac & Cardiovascular Systems, TAKO-TSUBO CARDIOMYOPATHY, COUPLED RECEPTOR KINASE-5, DIAGNOSTIC-CRITERIA, Cardiology, 610 Medicine & health, Pathophysiology, 2705 Cardiology and Cardiovascular Medicine, EMOTIONAL-STRESS, Oestrogen, Genetic, Takotsubo Cardiomyopathy, STRESS-INDUCED CARDIOMYOPATHY, Vascular, RAT MODEL, CATECHOLAMINE, Cardiovascular problems, Genetics, Humans, Medicine, Gonadal Steroid Hormones, Heart Failure, Takotsubo syndrome, Science & Technology, microRNA, business.industry, Inducible pluripotent stem cell model, medicine.disease, NERVOUS-SYSTEM, Cardiovascular physiology, MicroRNAs, Inducible pluripotent stem cell models, medicine.anatomical_structure, MODEL REVEALS, Heart failure, 10209 Clinic for Cardiology, Cardiovascular System & Cardiology, Cardiology and Cardiovascular Medicine, business, FOLLOW-UP, Life Sciences & Biomedicine, Hormone
Abstract: While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research. ispartof: EUROPEAN JOURNAL OF HEART FAILURE vol:24 issue:2 pages:274-286 ispartof: location:England status: published
Published: 2021

27. Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study

Author: Pham, Tài, Pesenti, Antonio, Bellani, Giacomo, Rubenfeld, Gordon, Fan, Eddy, Bugedo, Guillermo, Lorente, José Angel, Fernandes, Antero do Vale, Van Haren, Frank, Bruhn, Alejandro, Rios, Fernando, Esteban, Andres, Gattinoni, Luciano, Larsson, Anders, McAuley, Daniel F., Ranieri, Marco, Thompson, B. Taylor, Wrigge, Hermann, Brochard, Laurent J., Laffey, John G, Antonio Pesenti, John G Laffey, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Frank van Haren, Anders Larsson, Daniel F McAuley, Marco Ranieri, Gordon Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Giacomo Bellani, Tài Pham, Eddy Fan, Fernando Rios, Thierry Sottiaux, Pieter Depuydt, Fredy S Lora, Luciano Cesar Azevedo, Guillermo Bugedo, Haibo Qiu, Marcos Gonzalez, Juan Silesky, Vladimir Cerny, Jonas Nielsen, Manuel Jibaja, Dimitrios Matamis, Jorge Luis Ranero, Pravin Amin, S M Hashemian, Kevin Clarkson, Kiyoyasu Kurahashi, Asisclo Villagomez, Amine Ali Zeggwagh, Leo M Heunks, Jon Henrik Laake, Jose Emmanuel Palo, Antero do Vale Fernandes, Dorel Sandesc, Yaasen Arabi, Vesna Bumbasierevic, Nicolas Nin, Jose A Lorente, Lise Piquilloud, Fekri Abroug, Lia McNamee, Javier Hurtado, Ed Bajwa, Gabriel Démpaire, Hektor Sula, Lordian Nunci, Alma Cani, Alan Zazu, Christian Dellera, Carolina S Insaurralde, Risso V Alejandro, Julio Daldin, Mauricio Vinzio, Ruben O Fernandez, Luis P Cardonnet, Lisandro R Bettini, Mariano Carboni Bisso, Emilio M Osman, Mariano G Setten, Pablo Lovazzano, Javier Alvarez, Veronica Villar, Norberto C Pozo, Nicolas Grubissich, Gustavo A Plotnikow, Daniela N Vasquez, Santiago Ilutovich, Norberto Tiribelli, Ariel Chena, Carlos A Pellegrini, María G Saenz, Elisa Estenssoro, Matias Brizuela, Hernan Gianinetto, Pablo E Gomez, Valeria I Cerrato, Marco G Bezzi, Silvina A Borello, Flavia A Loiacono, Adriana M Fernandez, Serena Knowles, Claire Reynolds, Deborah M Inskip, Jennene J Miller, Jing Kong, Christina Whitehead, Shailesh Bihari, Aylin Seven, Amanda Krstevski, Helen J Rodgers, Rebecca T Millar, Toni E McKenna, Irene M Bailey, Gabrielle C Hanlon, Anders Aneman, Joan M Lynch, Raman Azad, John Neal, Paul W Woods, Brigit L Roberts, Mark R Kol, Helen S Wong, Katharina C Riss, Thomas Staudinger, Xavier Wittebole, Caroline Berghe, Pierre A Bulpa, Alain M Dive, Rik Verstraete, Herve Lebbinck, Joris Vermassen, Philippe Meersseman, Helga Ceunen, Jonas I Rosa, Daniel O Beraldo, Claudio Piras, Adenilton M Rampinelli, Antonio P Nassar Jr, Sergio Mataloun, Marcelo Moock, Marlus M Thompson, Claudio H Gonçalves, Ana Carolina P Antônio, Aline Ascoli, Rodrigo S Biondi, Danielle C Fontenele, Danielle Nobrega, Vanessa M Sales, Ahmad Yazid Bin Hj Abul Wahab, Maizatul Ismail, Suresh Shindhe, John Laffey, Francois Beloncle, Kyle G Davies, Rob Cirone, Venika Manoharan, Mehvish Ismail, Ewan C Goligher, Mandeep Jassal, Erin Nishikawa, Areej Javeed, Gerard Curley, Nuttapol Rittayamai, Matteo Parotto, Niall D Ferguson, Sangeeta Mehta, Jenny Knoll, Antoine Pronovost, Sergio Canestrini, Alejandro R Bruhn, Patricio H Garcia, Felipe A Aliaga, Pamela A Farías, Jacob S Yumha, Claudia A Ortiz, Javier E Salas, Alejandro A Saez, Luis D Vega, Eduardo F Labarca, Felipe T Martinez, Nicolás G Carreño, Pilar Lora, Haitao Liu, Ling Liu, Rui Tang, Xiaoming Luo, Youzhong An, Huiying Zhao, Yan Gao, Zhe Zhai, Zheng L Ye, Wei Wang, Wenwen Li, Qingdong Li, Ruiqiang Zheng, Wenkui Yu, Juanhong Shen, Xinyu Li, Tao Yu, Weihua Lu, Ya Q Wu, Xiao B Huang, Zhenyang He, Yuanhua Lu, Hui Han, Fan Zhang, Renhua Sun, Hua X Wang, Shu H Qin, Bao H Zhu, Jun Zhao, Jian Liu, Bin Li, Jing L Liu, Fa C Zhou, Qiong J Li, Xing Y Zhang, Zhou Li-Xin, Qiang Xin-Hua, Liangyan Jiang, Yuan N Gao, Xian Y Zhao, Yuan Y Li, Xiao L Li, Chunting Wang, Qingchun Yao, Rongguo Yu, Kai Chen, Huanzhang Shao, Bingyu Qin, Qing Q Huang, Wei H Zhu, Ai Y Hang, Ma X Hua, Yimin Li, Yonghao Xu, Yu D Di, Long L Ling, Tie H Qin, Shou H Wang, Junping Qin, Yi Han, Suming Zhou, Monica P Vargas, Juan I Silesky Jimenez, Manuel A González Rojas, Jaime E SolisQuesada, Christian M Ramirez-Alfaro, Jan Máca, Peter Sklienka, Jakob Gjedsted, Aage Christiansen, Boris G Villamagua, Iguel Llano, Philippe Burtin, Gautier Buzancais, Pascal Beuret, Nicolas Pelletier, Satar Mortaza, Alain Mercat, Jonathan Chelly, Sébastien Jochmans, Nicolas Terzi, Cédric Daubin, Guillaume Carteaux, Nicolas de Prost, Jean-Daniel Chiche, Fabrice Daviaud, Muriel Fartoukh, Guillaume Barberet, Jerome Biehler, Jean Dellamonica, Denis Doyen, Jean-Michel Arnal, Anais Briquet, Sami Hraiech, Laurent Papazian, Arnaud Follin, Damien Roux, Jonathan Messika, Evangelos Kalaitzis, Laurence Dangers, Alain Combes, Siu-Ming Au, Gaetan Béduneau, Dorothée Carpentier, Elie H Zogheib, Herve Dupont, Sylvie Ricome, Francesco L Santoli, Sebastien L Besset, Philippe Michel, Bruno Gelée, Pierre-Eric Danin, Bernard Goubaux, Philippe J Crova, Nga T Phan, Frantz Berkelmans, Julio C Badie, Romain Tapponnier, Josette Gally, Samy Khebbeb, Jean-Etienne Herbrecht, Francis Schneider, PierreLouis M Declercq, Jean-Philippe Rigaud, Jacques Duranteau, Anatole Harrois, Russell Chabanne, Julien Marin, Charlene Bigot, Sandrine Thibault, Mohammed Ghazi, Messabi Boukhazna, Salem Ould Zein, Jack R Richecoeur, Daniele M Combaux, Fabien Grelon, Charlene Le Moal, Elise P Sauvadet, Adrien Robine, Virginie Lemiale, Danielle Reuter, Martin Dres, Alexandre Demoule, Dany Goldgran-Toledano, Loredana Baboi, Claude Guérin, Ralph Lohner, Jens Kraßler, Susanne Schäfer, Kai D Zacharowski, Patrick Meybohm, Andreas W Reske, Philipp Simon, HansBernd F Hopf, Michael Schuetz, Thomas Baltus, Metaxia N Papanikolaou, Theonymfi G Papavasilopoulou, Giannis A Zacharas, Vasilis Ourailogloy, Eleni K Mouloudi, Eleni V Massa, Eva O Nagy, Electra E Stamou, Ellada V Kiourtzieva, Marina A Oikonomou, Luis E Avila, Cesar A Cortez, Johanna E Citalán, Sameer A Jog, Safal D Sable, Bhagyesh Shah, Mohan Gurjar, Arvind K Baronia, Mohammedfaruk Memon, Radhakrishnan Muthuchellappan, Venkatapura J Ramesh, Anitha Shenoy, Ramesh Unnikrishnan, Subhal B Dixit, Rachana V Rhayakar, Nagarajan Ramakrishnan, Vallish K Bhardwaj, Heera L Mahto, Sudha V Sagar, Vijayanand Palaniswamy, Deeban Ganesan, Seyed Mohammadreza Hashemian, Hamidreza Jamaati, Farshad Heidari, Edel A Meaney, Alistair Nichol, Karl M Knapman, Donall O'Croinin, Eimhin S Dunne, Dorothy M Breen, Kevin P Clarkson, Rola F Jaafar, Rory Dwyer, Fahd Amir, Olaitan O Ajetunmobi, Aogan C O'Muircheartaigh, Colin S Black, Nuala Treanor, Daniel V Collins, Wahid Altaf, Gianluca Zani, Maurizio Fusari, Savino Spadaro, Carlo A Volta, Romano Graziani, Barbara Brunettini, Salvatore Palmese, Paolo Formenti, Michele Umbrello, Andrea Lombardo, Elisabetta Pecci, Marco Botteri, Monica Savioli, Alessandro Protti, Alessia Mattei, Lorenzo Schiavoni, Andrea Tinnirello, Manuel Todeschini, Antonino Giarratano, Andrea Cortegiani, Massimo M Antonelli, Luca M Montini, Paolo Casalena, Sergio Scafetti, Giovanna Panarello, Giovanna Occhipinti, Nicolò Patroniti, Matteo Pozzi, Roberto R Biscione, Michela M Poli, Ferdinando Raimondi, Daniela Albiero, Giulia Crapelli, Eduardo Beck, Vincenzo Pota, Vincenzo Schiavone, Alexandre Molin, Fabio Tarantino, Giacomo Monti, Elena Frati, Lucia Mirabella, Gilda Cinnella, Tommaso Fossali, Riccardo Colombo, Pierpaolo Terragni, Ilaria Pattarino, Francesco Mojoli, Antonio Braschi, Erika E Borotto, Andrea N Cracchiolo, Daniela M Palma, Francesco Raponi, Giuseppe Foti, Ettore R Vascotto, Andrea Coppadoro, Luca Brazzi, Leda Floris, Giorgio A Iotti, Aaron Venti, Osamu Yamaguchi, Shunsuke Takagi, Hiroki N Maeyama, Eizo Watanabe, Yoshihiro Yamaji, Kazuyoshi Shimizu, Kyoko Shiozaki, Satoru Futami, Sekine Ryosuke, Koji Saito, Yoshinobu Kameyama, Keiko Ueno, Masayo Izawa, Nao Okuda, Hiroyuki Suzuki, Tomofumi Harasawa, Michitaka Nasu, Tadaaki Takada, Fumihito Ito, Shin Nunomiya, Kansuke Koyama, Toshikazu Abe, Kohkichi Andoh, Kohei Kusumoto, Akira Hirata, Akihiro Takaba, Hiroyasu Kimura, Shuhei Matsumoto, Ushio Higashijima, Hiroyuki Honda, Nobumasa Aoki, Hiroshi Imai, Yasuaki Ogino, Ichiko Mizuguchi, Kazuya Ichikado, Kenichi Nitta, Katsunori Mochizuki, Tomoaki Hashida, Hiroyuki Tanaka, Tomoyuki Nakamura, Daisuke Niimi, Takeshi Ueda, Yozo Kashiwa, Akinori Uchiyama, Olegs Sabelnikovs, Peteris Oss, Youssef Haddad, Kong Y Liew, Silvio A Ñamendys-Silva, Yves D Jarquin-Badiola, Luis A Sanchez-Hurtado, Saira S Gomez-Flores, Maria C Marin, Asisclo J Villagomez, Jordana S Lemus, Jonathan M Fierro, Mavy Ramirez Cervantes, Francisco Javier Flores Mejia, Dulce Dector, Alejandro Rojas, Daniel R Gonzalez, Claudia R Estrella, Jorge R Sanchez-Medina, Alvaro Ramirez-Gutierrez, Fernando G George, Janet S Aguirre, Juan A Buensuseso, Manuel Poblano, Tarek Dendane, Hicham Balkhi, Mina Elkhayari, Nacer Samkaoui, Hanane Ezzouine, Abdellatif Benslama, Mourad Amor, Wajdi Maazouzi, Nedim Cimic, Oliver Beck, Monique M Bruns, Jeroen A Schouten, Myra Rinia, Monique Raaijmakers, Hellen M van Wezel, Serge J Heines, Ulrich Strauch, Marc P Buise, Fabienne D Simonis, Marcus J Schultz, Jennifer C Goodson, Troy S Browne, Leanlove Navarra, Anna Hunt, Robyn A Hutchison, Mathew B Bailey, Lynette Newby, Colin McArthur, Michael Kalkoff, Alex Mcleod, Jonathan Casement, Danielle J Hacking, Finn H Andersen, Merete S Dolva, Jon H Laake, Andreas Barratt-Due, Kim Andre L Noremark, Eldar Søreide, Brit Å Sjøbø, Anne B Guttormsen, Hector H Leon Yoshido, Ronald Zumaran Aguilar, Fredy A Montes Oscanoa, Alain U Alisasis, Joanne B Robles, Rossini Abbie B Pasanting-Lim, Beatriz C Tan, Pawel Andruszkiewicz, Karina Jakubowska, Cristina M Coxo, António M Alvarez, Bruno S Oliveira, Gustavo M Montanha, Nelson C Barros, Carlos S Pereira, António M Messias, Jorge M Monteiro, Ana M Araujo, Nuno T Catorze, Susan M Marum, Maria J Bouw, Rui M Gomes, Vania A Brito, Silvia Castro, Joana M Estilita, Filipa M Barros, Isabel M Serra, Aurelia M Martinho, Dana R Tomescu, Alexandra Marcu, Ovidiu H Bedreag, Marius Papurica, Dan E Corneci, Silvius Ioan Negoita, Evgeny Grigoriev, Alexey I Gritsan, Andrey A Gazenkampf, Ghaleb Almekhlafi, Mohamad M Albarrak, Ghanem M Mustafa, Khalid A Maghrabi, Nawal Salahuddin, Tharwat M Aisa, Ahmed S Al Jabbary, Edgardo Tabhan, Yaseen M Arabi, Olivia A Trinidad, Hasan M Al Dorzi, Edgardo E Tabhan, Vesna Bumbasirevic, Bojan Jovanovic, Stefan Bolon, Oliver Smith, Jordi Mancebo, Hernan Aguirre-Bermeo, Juan C Lopez-Delgado, Francisco Esteve, Gemma Rialp, Catalina Forteza, Candelaria De Haro, Antonio Artigas, Guillermo M Albaiceta, Sara De Cima-Iglesias, Leticia Seoane-Quiroga, Alexandra Ceniceros-Barros, Antonio L RuizAguilar, Luis M Claraco-Vega, Juan Alfonso Soler, Maria Del Carmen Lorente, Cecilia Hermosa, Federico Gordo, Miryam PrietoGonzález, Juan B López-Messa, Manuel P Perez, Cesar P Perez, Raquel Montoiro Allue, Ferran RocheCampo, Marcos Ibañez-Santacruz, Susana TempranoSusana, Maria C Pintado, Raul De Pablo, Pilar Ricart Aroa Gómez, Silvia Rodriguez Ruiz, Silvia Iglesias Moles, Mª Teresa Jurado, Alfons Arizmendi, Enrique A Piacentini, Nieves Franco, Teresa Honrubia, Meisy Perez Cheng, Elena Perez Losada, Javier Blanco, Luis J Yuste, Cecilia Carbayo-Gorriz, Francisca G Cazorla-Barranquero, Javier G Alonso, Rosa S Alda, Ángela Algaba, Gonzalo Navarro, Enrique Cereijo, Esther Diaz-Rodriguez, Diego Pastor Marcos, Laura Alvarez Montero, Luis Herrera Para, Roberto Jimenez Sanchez, Miguel Angel Blasco Navalpotro, Ricardo Diaz Abad, Raquel Montiel González, Dácil Parrilla Toribio, Alejandro G Castro, Maria Jose D Artiga, Oscar Penuelas, Tomas P Roser, Moreno F Olga, Elena Gallego Curto, Rocío Manzano Sánchez, Vallverdu P Imma, Garcia M Elisabet, Laura Claverias, Monica Magret, Ana M Pellicer, Lucia L Rodriguez, Jesús Sánchez-Ballesteros, Ángela González-Salamanca, Antonio G Jimenez, Francisco P Huerta, Juan Carlos J Sotillo Diaz, Esther Bermejo Lopez, David D Llinares Moya, Alec A Tallet Alfonso, Palazon Sanchez Eugenio Luis, Palazon Sanchez Cesar, Sánchez I Rafael, Corcoles G Virgilio, Noelia N Recio, Christian C Rylander, Bernhard Holzgraefe, Lars M Broman, Joanna Wessbergh, Linnea Persson, Fredrik Schiöler, Hans Kedelv, Anna Oscarsson Tibblin, Henrik Appelberg, Lars Hedlund, Johan Helleberg, Karin E Eriksson, Rita Glietsch, Niklas Larsson, Ingela Nygren, Silvia L Nunes, Anna-Karin Morin, Thomas Kander, Anne Adolfsson, Hervé O Zender, Corinne Leemann-Refondini, Souheil Elatrous, Slaheddine Bouchoucha, Imed Chouchene, Islem Ouanes, Asma Ben Souissi, Salma Kamoun, Oktay Demirkiran, Mustafa Aker, Emre Erbabacan, Ilkay Ceylan, Nermin Kelebek Girgin, Menekse Ozcelik, Necmettin Ünal, Basak Ceyda Meco, Onat O Akyol, Suleyman S Derman, Barry Kennedy, Ken Parhar, Latha Srinivasa, Danny McAuley, Phil Hopkins, Clare Mellis, Vivek Kakar, Dan Hadfield, Andre Vercueil, Kaushik Bhowmick, Sally K Humphreys, Andrew Ferguson, Raymond Mckee, Ashok S Raj, Danielle A Fawkes, Philip Watt, Linda Twohey, Rajeev R Jha, Matthew Thomas, Alex Morton, Varsha Kadaba, Mark J Smith, Anil P Hormis, Santhana G Kannan, Miriam Namih, Henrik Reschreiter, Julie Camsooksai, Alek Kumar, Szabolcs Rugonfalvi, Christopher Nutt, Orla Oneill, Colette Seasman, Ged Dempsey, Christopher J Scott, Helen E Ellis, Stuart Mckechnie, Paula J Hutton, Nora N Di Tomasso, Michela N Vitale, Ruth O Griffin, Michael N 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Gazenkampf, Ghaleb Almekhlafi, Mohamad M Albarrak, Ghanem M Mustafa, Khalid A Maghrabi, Nawal Salahuddin, Tharwat M Aisa, Ahmed S Al Jabbary, Edgardo Tabhan, Yaseen M Arabi, Yaseen M Arabi, Olivia A Trinidad, Hasan M Al Dorzi, Edgardo E Tabhan, Vesna Bumbasirevic, Bojan Jovanovic, Stefan Bolon, Oliver Smith, Jordi Mancebo, Hernan Aguirre-Bermeo, Juan C Lopez-Delgado, Francisco Esteve, Gemma Rialp, Catalina Forteza, Candelaria De Haro, Antonio Artigas, Guillermo M Albaiceta, Sara De Cima-Iglesias, Leticia Seoane-Quiroga, Alexandra Ceniceros-Barros, Antonio L RuizAguilar, Luis M Claraco-Vega, Juan Alfonso Soler, Maria Del Carmen Lorente, Cecilia Hermosa, Federico Gordo, Miryam PrietoGonzález, Juan B López-Messa, Manuel P Perez, Cesar P Perez, Raquel Montoiro Allue, Ferran RocheCampo, Marcos Ibañez-Santacruz, Susana TempranoSusana, Maria C Pintado, Raul De Pablo, Pilar Ricart Aroa Gómez, Silvia Rodriguez Ruiz, Silvia Iglesias Moles, Mª Teresa Jurado, Alfons Arizmendi, Enrique A 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C Rylander, Bernhard Holzgraefe, Lars M Broman, Joanna Wessbergh, Linnea Persson, Fredrik Schiöler, Hans Kedelv, Anna Oscarsson Tibblin, Henrik Appelberg, Lars Hedlund, Johan Helleberg, Karin E Eriksson, Rita Glietsch, Niklas Larsson, Ingela Nygren, Silvia L Nunes, Anna-Karin Morin, Thomas Kander, Anne Adolfsson, Lise Piquilloud, Hervé O Zender, Corinne Leemann-Refondini, Souheil Elatrous, Slaheddine Bouchoucha, Imed Chouchene, Islem Ouanes, Asma Ben Souissi, Salma Kamoun, Oktay Demirkiran, Mustafa Aker, Emre Erbabacan, Ilkay Ceylan, Nermin Kelebek Girgin, Menekse Ozcelik, Necmettin Ünal, Basak Ceyda Meco, Onat O Akyol, Suleyman S Derman, Barry Kennedy, Ken Parhar, Latha Srinivasa, Lia McNamee, Danny McAuley, Phil Hopkins, Clare Mellis, Vivek Kakar, Dan Hadfield, Andre Vercueil, Kaushik Bhowmick, Sally K Humphreys, Andrew Ferguson, Raymond Mckee, Ashok S Raj, Danielle A Fawkes, Philip Watt, Linda Twohey, Rajeev R Jha, Matthew Thomas, Alex Morton, Varsha Kadaba, Mark J Smith, Anil P Hormis, Santhana G Kannan, Miriam Namih, Henrik Reschreiter, Julie Camsooksai, Alek Kumar, Szabolcs Rugonfalvi, Christopher Nutt, Orla Oneill, Colette Seasman, Ged Dempsey, Christopher J Scott, Helen E Ellis, Stuart Mckechnie, Paula J Hutton, Nora N Di Tomasso, Michela N Vitale, Ruth O Griffin, Michael N Dean, Julius H Cranshaw, Emma L Willett, Nicholas Ioannou, Sarah Gillis, Peter Csabi, Rosaleen Macfadyen, Heidi Dawson, Pieter D Preez, Alexandra J Williams, Owen Boyd, Laura Ortiz-Ruiz de Gordoa, Jon Bramall, Sophie Symmonds, Simon K Chau, Tim Wenham, Tamas Szakmany, Piroska Toth-Tarsoly, Katie H McCalman, Peter Alexander, Lorraine Stephenson, Thomas Collyer, Rhiannon Chapman, Raphael Cooper, Russell M Allan, Malcolm Sim, David W Wrathall, Donald A Irvine, Kim S Zantua, John C Adams, Andrew J Burtenshaw, Gareth P Sellors, Ingeborg D Welters, Karen E Williams, Robert J Hessell, Matthew G Oldroyd, Ceri E Battle, Suresh Pillai, Istvan Kajtor, Mageswaran Sivashanmugavel, Sinead C Okane, Adrian Donnelly, Aniko D Frigyik, Jon P Careless, Martin M May, Richard Stewart, T John Trinder, Samantha J Hagan, Jade M Cole, Caroline C MacFie, Anna T Dowling, Javier Hurtado, Nicolás Nin, Javier Hurtado, Edgardo Nuñez, Gustavo Pittini, Ruben Rodriguez, María C Imperio, Cristina Santos, Ana G França, Alejandro Ebeid, Alberto Deicas, Carolina Serra, Aditya Uppalapati, Ghassan Kamel, Valerie M Banner-Goodspeed, Jeremy R Beitler, Satyanarayana Reddy Mukkera, Shreedhar Kulkarni, John O Shinn Iii, Dina Gomaa, Christopher Tainter, Jarone Lee, Tomaz MesarJarone Lee, Dale J Yeatts, Jessica Warren, Michael J Lanspa, Russel R Miller, Colin K Grissom, Samuel M Brown, Philippe R Bauer, Ryan J Gosselin, Barrett T Kitch, Jason E Cohen, Scott H Beegle, Shazia Choudry, Renaud M Gueret, Aiman Tulaimat, William Stigler, Hitesh Batra, Nidhi G Huff, Keith D Lamb, Trevor W Oetting, Nicholas M Mohr, Claine Judy, Shigeki Saito, Fayez M Kheir, Fayez Kheir, Adam B Schlichting, Angela Delsing, Daniel R Crouch, Mary Elmasri, Daniel R Crouch, Dina Ismail, Kyle R Dreyer, Thomas C Blakeman, Dina Gomaa, Rebecca M Baro, Carolina Quintana Grijalba, Peter C Hou, Raghu Seethala, Imo Aisiku, Galen Henderson, Gyorgy Frendl, Sen-Kuang Hou, Robert L Owens, Ashley Schomer, Intensive Care Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, Pham, T, Pesenti, A, Bellani, G, Rubenfeld, G, Fan, E, Bugedo, G, Lorente, J, Fernandes, A, Van Haren, F, Bruhn, A, Rios, F, Esteban, A, Gattinoni, L, Larsson, A, Mcauley, D, Ranieri, M, Thompson, B, Wrigge, H, Brochard, L, Laffey, J, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), St. Michael's Hospital, University of Toronto, Groupe de recherche clinique CARMAS, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università degli Studi di Milano [Milano] (UNIMI), University of Milan, San Gerardo Hospital, Sunnybrook Health Sciences Center, Mount Sinai Hospital [Toronto, Canada] (MSH), Pontificia Universidad Católica de Chile (UC), University Hospital of Getafe, CIBER Enfermedades Respiratorias (CIBERES), Universidad Europea de Madrid, Hospital Garcia de Orta (EPE), Canberra Hospital, Medical School [Australian National University - ANU], Australian National University (ANU), University of Canberra, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), University of Göttingen - Georg-August-Universität Göttingen, Uppsala University, Queen's University [Belfast] (QUB), Royal Victoria Hospital, McGill University Health Center [Montreal] (MUHC), Università degli Studi di Bologna, Massachusetts General Hospital [Boston], University Hospital Leipzig, Department of Anaesthesiology, Intensive Care and Emergency Medicine, Pain Therapy, Bergmannstrost Hospital Halle, 06112, Halle, National University of Ireland [Galway] (NUI Galway), Bayer GlaxoSmithKline, GSK Baxter International Boehringer Ingelheim Wellcome Trust, WT National Institute for Health Research, NIHR Queen's University Belfast, QUB Medical Research Council Canada, MRC European Society of Intensive Care Medicine, ESICM, Support statement: This work was supported by the European Society of Intensive Care Medicine. Funding information for this article has been deposited with the Crossref Funder Registry., Conflict of interest: T. Pham has nothing to disclose. A. Pesenti reports personal fees from Maquet, Novalung/Xenios, Baxter, Gilead and Boehringer Ingelheim, outside the submitted work. G. Bellani reports grants and personal fees from Draeger Medical, personal fees from Getinge, Hamilton, GE Healthcare, Dimar SRL, Intersurgical and Flowmeter SPA, outside the submitted work. G. Rubenfeld has nothing to disclose. E. Fan reports personal fees from ALung Technologies, Getinge and MC3 Cardiopulmonary, grants, personal fees and non-financial support from Fresenius Medical Care, outside the submitted work. G. Bugedo has nothing to disclose. J.A. Lorente has nothing to disclose. A.D. V. Fernandes has nothing to disclose. F. Van Haren has nothing to disclose. A. Bruhn has nothing to disclose. F. Rios has nothing to disclose. A. Esteban has nothing to disclose. L. Gattinoni has nothing to disclose. A. Larsson reports grants from the Swedish Heart and Lung Foundation, during the conduct of the study. D.F. McAuley reports personal fees from consultancy for GlaxoSmithKline, Boehringer Ingelheim and Bayer, outside the submitted work, in addition, his institution has received funds from grants from the UK NIHR, Wellcome Trust, Innovate UK, NI HSC R&D Division, NI Chest Heart and Stroke, and MRC, is one of four named inventors on a patent US8962032 covering the use of sialic acid-bearing nanoparticles as anti-inflammatory agents issued to his institution, The Queen’s University of Belfast (http://www.google.com/patents/US8962032), and is a Director of Research for the Intensive Care Society and NIHR EME Programme Director. M. Ranieri has nothing to disclose. B.T. Thompson reports personal fees from Bayer, Thetis and Novartis, outside the submitted work. H. Wrigge reports personal fees for consultancy from Dräger Medical, personal fees for advisory board work from Liberate Medical, grants and personal fees for lectures from InfectoPharm, personal fees for lectures from MSD and GE, outside the submitted work. L.J. Brochard reports grants from Medtronic Covidien, grants and non-financial support from Fisher Paykel, non-financial support from Air Liquide, Sentec and Philips, other (patent) from General Electric, outside the submitted work. J.G. Laffey reports grants and personal fees from Baxter, grants and non-financial support from Aerogen and Factor Biosciences, outside the submitted work., LUNG SAFE Investigators and the European Society of Intensive Care Medicine Trials Group: Antonio Pesenti, John G Laffey, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Frank van Haren, Anders Larsson, Daniel F McAuley, Marco Ranieri, Gordon Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, John G Laffey, Giacomo Bellani, Tài Pham, Eddy Fan, Fernando Rios, Frank van Haren, Thierry Sottiaux, Pieter Depuydt, Fredy S Lora, Luciano Cesar Azevedo, Eddy Fan, Guillermo Bugedo, Haibo Qiu, Marcos Gonzalez, Juan Silesky, Vladimir Cerny, Jonas Nielsen, Manuel Jibaja, Tài Pham, Hermann Wrigge, Dimitrios Matamis, Jorge Luis Ranero, Pravin Amin, S M Hashemian, Kevin Clarkson, Giacomo Bellani, Kiyoyasu Kurahashi, Asisclo Villagomez, Amine Ali Zeggwagh, Leo M Heunks, Jon Henrik Laake, Jose Emmanuel Palo, Antero do Vale Fernandes, Dorel Sandesc, Yaasen Arabi, Vesna Bumbasierevic, Nicolas Nin, Jose A Lorente, Anders Larsson, Lise Piquilloud, Fekri Abroug, Daniel F McAuley, Lia McNamee, Javier Hurtado, Ed Bajwa, Gabriel Démpaire, Hektor Sula, Lordian Nunci, Alma Cani, Alan Zazu, Christian Dellera, Carolina S Insaurralde, Risso V Alejandro, Julio Daldin, Mauricio Vinzio, Ruben O Fernandez, Luis P Cardonnet, Lisandro R Bettini, Mariano Carboni Bisso, Emilio M Osman, Mariano G Setten, Pablo Lovazzano, Javier Alvarez, Veronica Villar, Norberto C Pozo, Nicolas Grubissich, Gustavo A Plotnikow, Daniela N Vasquez, Santiago Ilutovich, Norberto Tiribelli, Ariel Chena, Carlos A Pellegrini, María G Saenz, Elisa Estenssoro, Matias Brizuela, Hernan Gianinetto, Pablo E Gomez, Valeria I Cerrato, Marco G Bezzi, Silvina A Borello, Flavia A Loiacono, Adriana M Fernandez, Serena Knowles, Claire Reynolds, Deborah M Inskip, Jennene J Miller, Jing Kong, Christina Whitehead, Shailesh Bihari, Aylin Seven, Amanda Krstevski, Helen J Rodgers, Rebecca T Millar, Toni E McKenna, Irene M Bailey, Gabrielle C Hanlon, Anders Aneman, Joan M Lynch, Raman Azad, John Neal, Paul W Woods, Brigit L Roberts, Mark R Kol, Helen S Wong, Katharina C Riss, Thomas Staudinger, Xavier Wittebole, Caroline Berghe, Pierre A Bulpa, Alain M Dive, Rik Verstraete, Herve Lebbinck, Pieter Depuydt, Joris Vermassen, Philippe Meersseman, Helga Ceunen, Jonas I Rosa, Daniel O Beraldo, Claudio Piras, Adenilton M Rampinelli, Antonio P Nassar Jr, Sergio Mataloun, Marcelo Moock, Marlus M Thompson, Claudio H Gonçalves, Ana Carolina P Antônio, Aline Ascoli, Rodrigo S Biondi, Danielle C Fontenele, Danielle Nobrega, Vanessa M Sales, Ahmad Yazid Bin Hj Abul Wahab, Maizatul Ismail, Suresh Shindhe, John Laffey, Francois Beloncle, Kyle G Davies, Rob Cirone, Venika Manoharan, Mehvish Ismail, Ewan C Goligher, Mandeep Jassal, Erin Nishikawa, Areej Javeed, Gerard Curley, Nuttapol Rittayamai, Matteo Parotto, Niall D Ferguson, Sangeeta Mehta, Jenny Knoll, Antoine Pronovost, Sergio Canestrini, Alejandro R Bruhn, Patricio H Garcia, Felipe A Aliaga, Pamela A Farías, Jacob S Yumha, Claudia A Ortiz, Javier E Salas, Alejandro A Saez, Luis D Vega, Eduardo F Labarca, Felipe T Martinez, Nicolás G Carreño, Pilar Lora, Haitao Liu, Haibo Qiu, Ling Liu, Rui Tang, Xiaoming Luo, Youzhong An, Huiying Zhao, Yan Gao, Zhe Zhai, Zheng L Ye, Wei Wang, Wenwen Li, Qingdong Li, Ruiqiang Zheng, Wenkui Yu, Juanhong Shen, Xinyu Li, Tao Yu, Weihua Lu, Ya Q Wu, Xiao B Huang, Zhenyang He, Yuanhua Lu, Hui Han, Fan Zhang, Renhua Sun, Hua X Wang, Shu H Qin, Bao H Zhu, Jun Zhao, Jian Liu, Bin Li, Jing L Liu, Fa C Zhou, Qiong J Li, Xing Y Zhang, Zhou Li-Xin, Qiang Xin-Hua, Liangyan Jiang, Yuan N Gao, Xian Y Zhao, Yuan Y Li, Xiao L Li, Chunting Wang, Qingchun Yao, Rongguo Yu, Kai Chen, Huanzhang Shao, Bingyu Qin, Qing Q Huang, Wei H Zhu, Ai Y Hang, Ma X Hua, Yimin Li, Yonghao Xu, Yu D Di, Long L Ling, Tie H Qin, Shou H Wang, Junping Qin, Yi Han, Suming Zhou, Monica P Vargas, Juan I Silesky Jimenez, Manuel A González Rojas, Jaime E SolisQuesada, Christian M Ramirez-Alfaro, Jan Máca, Peter Sklienka, Jakob Gjedsted, Aage Christiansen, Jonas Nielsen, Boris G Villamagua, Iguel Llano, Philippe Burtin, Gautier Buzancais, Pascal Beuret, Nicolas Pelletier, Satar Mortaza, Alain Mercat, Jonathan Chelly, Sébastien Jochmans, Nicolas Terzi, Cédric Daubin, Guillaume Carteaux, Nicolas de Prost, Jean-Daniel Chiche, Fabrice Daviaud, Tài Pham, Muriel Fartoukh, Guillaume Barberet, Jerome Biehler, Jean Dellamonica, Denis Doyen, Jean-Michel Arnal, Anais Briquet, Sami Hraiech, Laurent Papazian, Arnaud Follin, Damien Roux, Jonathan Messika, Evangelos Kalaitzis, Laurence Dangers, Alain Combes, Siu-Ming Au, Gaetan Béduneau, Dorothée Carpentier, Elie H Zogheib, Herve Dupont, Sylvie Ricome, Francesco L Santoli, Sebastien L Besset, Philippe Michel, Bruno Gelée, Pierre-Eric Danin, Bernard Goubaux, Philippe J Crova, Nga T Phan, Frantz Berkelmans, Julio C Badie, Romain Tapponnier, Josette Gally, Samy Khebbeb, Jean-Etienne Herbrecht, Francis Schneider, PierreLouis M Declercq, Jean-Philippe Rigaud, Jacques Duranteau, Anatole Harrois, Russell Chabanne, Julien Marin, Charlene Bigot, Sandrine Thibault, Mohammed Ghazi, Messabi Boukhazna, Salem Ould Zein, Jack R Richecoeur, Daniele M Combaux, Fabien Grelon, Charlene Le Moal, Elise P Sauvadet, Adrien Robine, Virginie Lemiale, Danielle Reuter, Martin Dres, Alexandre Demoule, Dany Goldgran-Toledano, Loredana Baboi, Claude Guérin, Ralph Lohner, Jens Kraßler, Susanne Schäfer, Kai D Zacharowski, Patrick Meybohm, Andreas W Reske, Philipp Simon, HansBernd F Hopf, Michael Schuetz, Thomas Baltus, Metaxia N Papanikolaou, Theonymfi G Papavasilopoulou, Giannis A Zacharas, Vasilis Ourailogloy, Eleni K Mouloudi, Eleni V Massa, Eva O Nagy, Electra E Stamou, Ellada V Kiourtzieva, Marina A Oikonomou, Luis E Avila, Cesar A Cortez, Johanna E Citalán, Sameer A Jog, Safal D Sable, Bhagyesh Shah, Mohan Gurjar, Arvind K Baronia, Mohammedfaruk Memon, Radhakrishnan Muthuchellappan, Venkatapura J Ramesh, Anitha Shenoy, Ramesh Unnikrishnan, Subhal B Dixit, Rachana V Rhayakar, Nagarajan Ramakrishnan, Vallish K Bhardwaj, Heera L Mahto, Sudha V Sagar, Vijayanand Palaniswamy, Deeban Ganesan, Seyed Mohammadreza Hashemian, Hamidreza Jamaati, Farshad Heidari, Edel A Meaney, Alistair Nichol, Karl M Knapman, Donall O'Croinin, Eimhin S Dunne, Dorothy M Breen, Kevin P Clarkson, Rola F Jaafar, Rory Dwyer, Fahd Amir, Olaitan O Ajetunmobi, Aogan C O'Muircheartaigh, Colin S Black, Nuala Treanor, Daniel V Collins, Wahid Altaf, Gianluca Zani, Maurizio Fusari, Savino Spadaro, Carlo A Volta, Romano Graziani, Barbara Brunettini, Salvatore Palmese, Paolo Formenti, Michele Umbrello, Andrea Lombardo, Elisabetta Pecci, Marco Botteri, Monica Savioli, Alessandro Protti, Alessia Mattei, Lorenzo Schiavoni, Andrea Tinnirello, Manuel Todeschini, Antonino Giarratano, Andrea Cortegiani, Antonino Giarratano, Andrea Cortegiani, Massimo M Antonelli, Luca M Montini, Paolo Casalena, Sergio Scafetti, Giovanna Panarello, Giovanna Occhipinti, Nicolò Patroniti, Matteo Pozzi, Roberto R Biscione, Michela M Poli, Ferdinando Raimondi, Daniela Albiero, Giulia Crapelli, Eduardo Beck, Vincenzo Pota, Vincenzo Schiavone, Alexandre Molin, Fabio Tarantino, Giacomo Monti, Elena Frati, Lucia Mirabella, Gilda Cinnella, Tommaso Fossali, Riccardo Colombo, Pierpaolo Terragni, Ilaria Pattarino, Francesco Mojoli, Antonio Braschi, Erika E Borotto, Andrea N Cracchiolo, Daniela M Palma, Francesco Raponi, Giuseppe Foti, Ettore R Vascotto, Andrea Coppadoro, Luca Brazzi, Leda Floris, Giorgio A Iotti, Aaron Venti, Osamu Yamaguchi, Shunsuke Takagi, Hiroki N Maeyama, Eizo Watanabe, Yoshihiro Yamaji, Kazuyoshi Shimizu, Kyoko Shiozaki, Satoru Futami, Sekine Ryosuke, Koji Saito, Yoshinobu Kameyama, Keiko Ueno, Masayo Izawa, Nao Okuda, Hiroyuki Suzuki, Tomofumi Harasawa, Michitaka Nasu, Tadaaki Takada, Fumihito Ito, Shin Nunomiya, Kansuke Koyama, Toshikazu Abe, Kohkichi Andoh, Kohei Kusumoto, Akira Hirata, Akihiro Takaba, Hiroyasu Kimura, Shuhei Matsumoto, Ushio Higashijima, Hiroyuki Honda, Nobumasa Aoki, Hiroshi Imai, Yasuaki Ogino, Ichiko Mizuguchi, Kazuya Ichikado, Kenichi Nitta, Katsunori Mochizuki, Tomoaki Hashida, Hiroyuki Tanaka, Tomoyuki Nakamura, Daisuke Niimi, Takeshi Ueda, Yozo Kashiwa, Akinori Uchiyama, Olegs Sabelnikovs, Peteris Oss, Youssef Haddad, Kong Y Liew, Silvio A Ñamendys-Silva, Yves D Jarquin-Badiola, Luis A Sanchez-Hurtado, Saira S Gomez-Flores, Maria C Marin, Asisclo J Villagomez, Jordana S Lemus, Jonathan M Fierro, Mavy Ramirez Cervantes, Francisco Javier Flores Mejia, Dulce Dector, Alejandro Rojas, Daniel R Gonzalez, Claudia R Estrella, Jorge R Sanchez-Medina, Alvaro Ramirez-Gutierrez, Fernando G George, Janet S Aguirre, Juan A Buensuseso, Manuel Poblano, Juan A Buensuseso, Manuel Poblano, Tarek Dendane, Amine Ali Zeggwagh, Hicham Balkhi, Mina Elkhayari, Nacer Samkaoui, Hanane Ezzouine, Abdellatif Benslama, Mourad Amor, Wajdi Maazouzi, Nedim Cimic, Oliver Beck, Monique M Bruns, Jeroen A Schouten, Myra Rinia, Monique Raaijmakers, Leo M Heunks, Hellen M van Wezel, Serge J Heines, Ulrich Strauch, Marc P Buise, Fabienne D Simonis, Marcus J Schultz, Jennifer C Goodson, Troy S Browne, Leanlove Navarra, Anna Hunt, Robyn A Hutchison, Mathew B Bailey, Lynette Newby, Colin McArthur, Michael Kalkoff, Alex Mcleod, Jonathan Casement, Danielle J Hacking, Finn H Andersen, Merete S Dolva, Jon H Laake, Andreas Barratt-Due, Kim Andre L Noremark, Eldar Søreide, Brit Å Sjøbø, Anne B Guttormsen, Hector H Leon Yoshido, Ronald Zumaran Aguilar, Fredy A Montes Oscanoa, Alain U Alisasis, Joanne B Robles, Rossini Abbie B Pasanting-Lim, Beatriz C Tan, Pawel Andruszkiewicz, Karina Jakubowska, Cristina M Coxo, António M Alvarez, Bruno S Oliveira, Gustavo M Montanha, Nelson C Barros, Carlos S Pereira, António M Messias, Jorge M Monteiro, Ana M Araujo, Nuno T Catorze, Susan M Marum, Maria J Bouw, Rui M Gomes, Vania A Brito, Silvia Castro, Joana M 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Carlos J Sotillo Diaz, Esther Bermejo Lopez, David D Llinares Moya, Alec A Tallet Alfonso, Palazon Sanchez Eugenio Luis, Palazon Sanchez Cesar, Sánchez I Rafael, Corcoles G Virgilio, Noelia N Recio, Christian C Rylander, Bernhard Holzgraefe, Lars M Broman, Joanna Wessbergh, Linnea Persson, Fredrik Schiöler, Hans Kedelv, Anna Oscarsson Tibblin, Henrik Appelberg, Lars Hedlund, Johan Helleberg, Karin E Eriksson, Rita Glietsch, Niklas Larsson, Ingela Nygren, Silvia L Nunes, Anna-Karin Morin, Thomas Kander, Anne Adolfsson, Lise Piquilloud, Hervé O Zender, Corinne Leemann-Refondini, Souheil Elatrous, Slaheddine Bouchoucha, Imed Chouchene, Islem Ouanes, Asma Ben Souissi, Salma Kamoun, Oktay Demirkiran, Mustafa Aker, Emre Erbabacan, Ilkay Ceylan, Nermin Kelebek Girgin, Menekse Ozcelik, Necmettin Ünal, Basak Ceyda Meco, Onat O Akyol, Suleyman S Derman, Barry Kennedy, Ken Parhar, Latha Srinivasa, Lia McNamee, Danny McAuley, Phil Hopkins, Clare Mellis, Vivek Kakar, Dan Hadfield, Andre Vercueil, Kaushik Bhowmick, Sally K Humphreys, Andrew Ferguson, Raymond Mckee, Ashok S Raj, Danielle A Fawkes, Philip Watt, Linda Twohey, Rajeev R Jha, Matthew Thomas, Alex Morton, Varsha Kadaba, Mark J Smith, Anil P Hormis, Santhana G Kannan, Miriam Namih, Henrik Reschreiter, Julie Camsooksai, Alek Kumar, Szabolcs Rugonfalvi, Christopher Nutt, Orla Oneill, Colette Seasman, Ged Dempsey, Christopher J Scott, Helen E Ellis, Stuart Mckechnie, Paula J Hutton, Nora N Di Tomasso, Michela N Vitale, Ruth O Griffin, Michael N Dean, Julius H Cranshaw, Emma L Willett, Nicholas Ioannou, Sarah Gillis, Peter Csabi, Rosaleen Macfadyen, Heidi Dawson, Pieter D Preez, Alexandra J Williams, Owen Boyd, Laura Ortiz-Ruiz de Gordoa, Jon Bramall, Sophie Symmonds, Simon K Chau, Tim Wenham, Tamas Szakmany, Piroska Toth-Tarsoly, Katie H McCalman, Peter Alexander, Lorraine Stephenson, Thomas Collyer, Rhiannon Chapman, Raphael Cooper, Russell M Allan, Malcolm Sim, David W Wrathall, Donald A Irvine, Kim S Zantua, John C 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Tulaimat, William Stigler, Hitesh Batra, Nidhi G Huff, Keith D Lamb, Trevor W Oetting, Nicholas M Mohr, Claine Judy, Shigeki Saito, Fayez M Kheir, Fayez Kheir, Adam B Schlichting, Angela Delsing, Daniel R Crouch, Mary Elmasri, Daniel R Crouch, Dina Ismail, Kyle R Dreyer, Thomas C Blakeman, Dina Gomaa, Rebecca M Baro, Carolina Quintana Grijalba, Peter C Hou, Raghu Seethala, Imo Aisiku, Galen Henderson, Gyorgy Frendl, Sen-Kuang Hou, Robert L Owens, Ashley Schomer, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, and UCL - (SLuc) Service de soins intensifs
Subjects: Pulmonary and Respiratory Medicine, ARDS, Unidades de cuidados intensivos, [SDV]Life Sciences [q-bio], medicine.medical_treatment, mechanical ventilation, NO, law.invention, 03 medical and health sciences, Tratamiento médico, 0302 clinical medicine, law, Settore MED/41 - ANESTESIOLOGIA, Insuficiencia respiratoria, Medicine, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Lung, Mechanical ventilation, Respiratory Distress Syndrome, business.industry, Respiration, Incidence (epidemiology), medicine.disease, Intensive care unit, Respiration, Artificial, 3. Good health, Intensive Care Units, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], medicine.anatomical_structure, 030228 respiratory system, Respiratory failure, Heart failure, Anesthesia, Artificial, ards, business, Respiratory Insufficiency, Enfermedad
Abstract: BackgroundCurrent incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).MethodsAn international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ventilation, conducted during four consecutive weeks in the winter of 2014 in 459 ICUs from 50 countries (LUNG SAFE). Patients were enrolled with arterial oxygen tension/inspiratory oxygen fraction ratio ≤300 mmHg, new pulmonary infiltrates and need for mechanical ventilation with a positive end-expiratory pressure of ≥5 cmH2O. ICU prevalence, causes of hypoxaemia, hospital survival and factors associated with hospital mortality were measured. Patients with unilateral versus bilateral opacities were compared.Findings12 906 critically ill patients received mechanical ventilation and 34.9% with hypoxaemia and new infiltrates were enrolled, separated into ARDS (69.0%), unilateral infiltrate (22.7%) and congestive heart failure (CHF; 8.2%). The global hospital mortality was 38.6%. CHF patients had a mortality comparable to ARDS (44.1% versus 40.4%). Patients with unilateral-infiltrate had lower unadjusted mortality, but similar adjusted mortality compared to those with ARDS. The number of quadrants on chest imaging was associated with an increased risk of death. There was no difference in mortality comparing patients with unilateral-infiltrate and ARDS with only two quadrants involved.InterpretationMore than one-third of patients receiving mechanical ventilation have hypoxaemia and new infiltrates with a hospital mortality of 38.6%. Survival is dependent on the degree of pulmonary involvement whether or not ARDS criteria are reached.
Published: 2021
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28. Death in hospital following ICU discharge: insights from the LUNG SAFE study

Author: Madotto F., McNicholas B., Rezoagli E., Pham T., Laffey J. G., Bellani G., Pesenti A., Brochard L., Esteban A., Gattinoni L., van Haren F., Ranieri M., Rubenfeld G., Thompson B. T., Slutsky A. S., Rios F., Faruq M. O., Sottiaux T., Depuydt P., Lora F. S., Azevedo C. C., Fan E., Bugedo G., Qiu H., Gonzalez M., Silesky J., Cerny V., Nielsen J., Jibaja M., Wrigge H., Matamis D., Ranero J. L., Gomersall C., Amin P., Hashemian S. M., Clarkson K., Kurahashi K., Koh Y., Villagomez A., Zeggwagh A. A., Heunks L. M., Laake J. H., Kashif W., Synclair J., Palo J. E., do Vale Fernandes A., Sandesc D., Arabi Y., Bumbasierevic V., Nin N., Lorente J. A., Larsson A., Piquilloud L., Patjanasoontorn B., Abroug F., McAuley D. F., McNamee L., Hurtado J., Bajwa E., Dempaire G., Francois G. M., Rabboni F., Conti S., Sula H., Nunci L., Cani A., Zazu A., Dellera C., Insaurralde C. S., Alejandro R. V., Daldin J., Vinzio M., Fernandez R. O., Cardonnet L. P., Bettini L. R., Bisso M. C., Osman E. M., Setten M. G., Lovazzano P., Alvarez J., Villar V., Pozo N. C., Grubissich N., Plotnikow G. A., Vasquez D. N., Ilutovich S., Tiribelli N., Chena A., Pellegrini C. A., Saenz M. G., Estenssoro E., Brizuela M., Gianinetto H., Gomez P. E., Cerrato V. I., Bezzi M. G., Borello S. A., Loiacono F. A., Fernandez A. M., Knowles S., Reynolds C., Inskip D. M., Miller J. J., Kong J., Whitehead C., Bihari S., Seven A., Krstevski A., Rodgers H. J., Millar R. T., Mckenna T. E., Bailey I. M., Hanlon G. C., Aneman A., Lynch J. M., Azad R., Neal J., Woods P. W., Roberts B. L., Kol M. R., Wong H. S., Riss K. C., Staudinger T., Wittebole X., Berghe C., Bulpa P. A., Dive A. M., Verstraete R., Lebbinck H., Vermassen J., Meersseman P., Ceunen H., Rosa J. I., Beraldo D. O., Piras C., Rampinelli A. M., Nassar N. P., Mataloun S., Moock M., Thompson M. M., Goncalves C. H., Antonio A. C. P., Ascoli A., Biondi R. S., Fontenele D. C., Nobrega D., Sales V. M., Shindhe S., Aiman D. M., Ismail B. P. H., Laffey J., Beloncle F., Davies K. G., Cirone R., Manoharan V., Ismail M., Goligher E. C., Jassal M., Ferguson N. D., Nishikawa E., Javeed A., Curley G., Rittayamai N., Parotto M., Mehta S., Knoll J., Pronovost A., Canestrini S., Bruhn A. R., Garcia P. H., Aliaga F. A., Farias P. A., Yumha J. S., Ortiz C. A., Salas J. E., Saez A. A., Vega L. D., Labarca E. F., Martinez F. T., Carreno N. G., Lora P., Liu H., Liu L., Tang R., Luo X., An Y., Zhao H., Gao Y., Zhai Z., Ye Z. L., Wang W., Li W., Li Q., Zheng R., Yu W., Shen J., Li X., Yu T., Lu W., Wu Y. Q., Huang X. B., He Z., Lu Y., Han H., Zhang F., Sun R., Wang H. X., Qin S. H., Zhu B. H., Zhao J., Liu J., Li B., Liu J. L., Zhou F. C., Li Q. J., Zhang X. Y., Li-Xin Z., Xin-Hua Q., Jiang L., Gao Y. N., Zhao X. Y., Li Y. Y., Li X. L., Wang C., Yao Q., Yu R., Chen K., Shao H., Qin B., Huang Q. Q., Zhu W. H., Hang A. Y., Hua M. X., Li Y., Xu Y., Di Y. D., Ling L. L., Qin T. H., Wang S. H., Qin J., Han Y., Zhou S., Vargas M. P., Jimenez J. I. S., Rojas M. A. G., Solis-Quesada J. E., Ramirez-Alfaro C. M., Maca J., Sklienka P., Gjedsted J., Christiansen A., Villamagua B. G., Llano M., Burtin P., Buzancais G., Beuret P., Pelletier N., Mortaza S., Mercat A., Chelly J., Jochmans S., Terzi N., Daubin C., Carteaux G., de Prost N., Chiche J. -D., Daviaud F., Fartoukh M., Barberet G., Biehler J., Dellamonica J., Doyen D., Arnal J. -M., Briquet A., Klasen F., Papazian L., Follin A., Roux D., Messika J., Kalaitzis E., Dangers L., Combes A., Au S. -M., Beduneau G., Carpentier D., Zogheib E. H., Dupont H., Ricome S., Santoli F. L., Besset S. L., Michel P., Gelee B., Danin P. -E., Goubaux B., Crova P. J., Phan N. T., Berkelmans F., Badie J. C., Tapponnier R., Gally J., Khebbeb S., Herbrecht J. -E., Schneider F., Declercq P. -L. M., Rigaud J. -P., Duranteau J., Harrois A., Chabanne R., Marin J., Constantin J. -M., Thibault S., Ghazi M., Boukhazna M., Zein S. O., Richecoeur J. R., Combaux D. 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V., Altaf W., Zani G., Fusari M., Spadaro S., Volta C. A., Graziani R., Brunettini B., Palmese S., Formenti P., Umbrello M., Lombardo A., Pecci E., Botteri M., Savioli M., Protti A., Mattei A., Schiavoni L., Tinnirello A., Todeschini M., Giaccone P. P., Giarratano A., Cortegiani A., Sher S., Rossi A., Antonelli M. M., Montini L. M., Casalena P., Scafetti S., Panarello G., Occhipinti G., Patroniti N., Pozzi M., Biscione R. R., Poli M. M., Raimondi F., Albiero D., Crapelli G., Beck E., Pota V., Schiavone V., Molin A., Tarantino F., Monti G., Frati E., Mirabella L., Cinnella G., Fossali T., Colombo R., Pattarino P. T. I., Mojoli F., Braschi A., Borotto E. E., Cracchiolo A. N., Palma D. M., Raponi F., Foti G., Vascotto E. R., Coppadoro A., Brazzi L., Floris L., Iotti G. A., Venti A., Yamaguchi O., Takagi S., Maeyama H. 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M., Schouten J. A., Rinia M., Raaijmakers M., Van Wezel H. M., Heines S. J., Strauch U., Buise M. P., Simonis F. D., Schultz M. J., Goodson J. C., Browne T. S., Navarra L., Hunt A., Hutchison R. A., Bailey M. B., Newby L., Mcarthur C., Kalkoff M., Mcleod A., Casement J., Hacking D. J., Andersen F. H., Dolva M. S., Barratt-Due A., Noremark K. A. L., Soreide E., Sjobo B. A., Guttormsen A. B., Yoshido H. H. L., Aguilar R. Z., Oscanoa F. A. M., Alisasis A. U., Robles J. B., Pasanting-Lim R. A. B., Tan B. C., Andruszkiewicz P., Jakubowska K., Coxo C. M., Alvarez A. M., Oliveira B. S., Montanha G. M., Barros N. C., Pereira C. S., Messias A. M., Monteiro J. M., Araujo A. M., Catorze N. T., Marum S. M., Bouw M. J., Gomes R. M., Brito V. A., Castro S., Estilita J. M., Barros F. M., Serra I. M., Martinho A. M., Tomescu D. R., Marcu A., Bedreag O. H., Papurica M., Corneci D. E., Negoita S. I., Grigoriev E., Gritsan A. I., Gazenkampf A. A., Almekhlafi G., Albarrak M. M., Mustafa G. 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L., Schomer A., Bumbasirevic V., Jovanovic B., Surbatovic M., Veljovic M., Madotto, F., Mcnicholas, B., Rezoagli, E., Pham, T., Laffey, J. G., Bellani, G., Pesenti, A., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Ranieri, M., Rubenfeld, G., Thompson, B. T., Slutsky, A. S., Rios, F., Faruq, M. O., Sottiaux, T., Depuydt, P., Lora, F. S., Azevedo, C. C., Fan, E., Bugedo, G., Qiu, H., Gonzalez, M., Silesky, J., Cerny, V., Nielsen, J., Jibaja, M., Wrigge, H., Matamis, D., Ranero, J. L., Gomersall, C., Amin, P., Hashemian, S. M., Clarkson, K., Kurahashi, K., Koh, Y., Villagomez, A., Zeggwagh, A. A., Heunks, L. M., Laake, J. H., Kashif, W., Synclair, J., Palo, J. E., do Vale Fernandes, A., Sandesc, D., Arabi, Y., Bumbasierevic, V., Nin, N., Lorente, J. A., Larsson, A., Piquilloud, L., Patjanasoontorn, B., Abroug, F., Mcauley, D. F., Mcnamee, L., Hurtado, J., Bajwa, E., Dempaire, G., Francois, G. M., Rabboni, F., Conti, S., Sula, H., Nunci, L., Cani, A., Zazu, A., Dellera, C., Insaurralde, C. S., Alejandro, R. V., Daldin, J., Vinzio, M., Fernandez, R. O., Cardonnet, L. P., Bettini, L. R., Bisso, M. C., Osman, E. M., Setten, M. G., Lovazzano, P., Alvarez, J., Villar, V., Pozo, N. C., Grubissich, N., Plotnikow, G. A., Vasquez, D. N., Ilutovich, S., Tiribelli, N., Chena, A., Pellegrini, C. A., Saenz, M. G., Estenssoro, E., Brizuela, M., Gianinetto, H., Gomez, P. E., Cerrato, V. I., Bezzi, M. G., Borello, S. A., Loiacono, F. A., Fernandez, A. M., Knowles, S., Reynolds, C., Inskip, D. M., Miller, J. J., Kong, J., Whitehead, C., Bihari, S., Seven, A., Krstevski, A., Rodgers, H. J., Millar, R. T., Mckenna, T. E., Bailey, I. M., Hanlon, G. C., Aneman, A., Lynch, J. M., Azad, R., Neal, J., Woods, P. W., Roberts, B. L., Kol, M. R., Wong, H. S., Riss, K. C., Staudinger, T., Wittebole, X., Berghe, C., Bulpa, P. A., Dive, A. 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B., He, Z., Lu, Y., Han, H., Zhang, F., Sun, R., Wang, H. X., Qin, S. H., Zhu, B. H., Zhao, J., Liu, J., Li, B., Liu, J. L., Zhou, F. C., Li, Q. J., Zhang, X. Y., Li-Xin, Z., Xin-Hua, Q., Jiang, L., Gao, Y. N., Zhao, X. Y., Li, Y. Y., Li, X. L., Wang, C., Yao, Q., Yu, R., Chen, K., Shao, H., Qin, B., Huang, Q. Q., Zhu, W. H., Hang, A. Y., Hua, M. X., Li, Y., Xu, Y., Di, Y. D., Ling, L. L., Qin, T. H., Wang, S. H., Qin, J., Han, Y., Zhou, S., Vargas, M. P., Jimenez, J. I. S., Rojas, M. A. G., Solis-Quesada, J. E., Ramirez-Alfaro, C. M., Maca, J., Sklienka, P., Gjedsted, J., Christiansen, A., Villamagua, B. 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P., Robine, A., Lemiale, V., Reuter, D., Dres, M., Demoule, A., Goldgran-Toledano, D., Baboi, L., Guerin, C., Lohner, R., Krassler, J., Schafer, S., Zacharowski, K. D., Meybohm, P., Reske, A. W., Simon, P., Hopf, H. -B. F., Schuetz, M., Baltus, T., Papanikolaou, M. N., Papavasilopoulou, T. G., Zacharas, G. A., Ourailogloy, V., Mouloudi, E. K., Massa, E. V., Nagy, E. O., Stamou, E. E., Kiourtzieva, E. V., Oikonomou, M. A., Avila, L. E., Cortez, C. A., Citalan, J. E., Jog, S. A., Sable, S. D., Shah, B., Gurjar, M., Baronia, A. K., Memon, M., Muthuchellappan, R., Ramesh, V. J., Shenoy, A., Unnikrishnan, R., Dixit, S. B., Rhayakar, R. V., Ramakrishnan, N., Bhardwaj, V. K., Mahto, H. L., Sagar, S. V., Palaniswamy, V., Ganesan, D., Jamaati, H., Heidari, F., Meaney, E. A., Nichol, A., Knapman, K. M., O'Croinin, D., Dunne, E. S., Breen, D. M., Clarkson, K. P., Jaafar, R. F., Dwyer, R., Amir, F., Ajetunmobi, O. O., O'Muircheartaigh, A. C., Black, C. S., Treanor, N., Collins, D. V., Altaf, W., Zani, G., Fusari, M., Spadaro, S., Volta, C. A., Graziani, R., Brunettini, B., Palmese, S., Formenti, P., Umbrello, M., Lombardo, A., Pecci, E., Botteri, M., Savioli, M., Protti, A., Mattei, A., Schiavoni, L., Tinnirello, A., Todeschini, M., Giaccone, P. P., Giarratano, A., Cortegiani, A., Sher, S., Rossi, A., Antonelli, M. M., Montini, L. M., Casalena, P., Scafetti, S., Panarello, G., Occhipinti, G., Patroniti, N., Pozzi, M., Biscione, R. R., Poli, M. M., Raimondi, F., Albiero, D., Crapelli, G., Beck, E., Pota, V., Schiavone, V., Molin, A., Tarantino, F., Monti, G., Frati, E., Mirabella, L., Cinnella, G., Fossali, T., Colombo, R., Pattarino, P. T. I., Mojoli, F., Braschi, A., Borotto, E. E., Cracchiolo, A. N., Palma, D. M., Raponi, F., Foti, G., Vascotto, E. R., Coppadoro, A., Brazzi, L., Floris, L., Iotti, G. A., Venti, A., Yamaguchi, O., Takagi, S., Maeyama, H. N., Watanabe, E., Yamaji, Y., Shimizu, K., Shiozaki, K., Futami, S., Ryosuke, S., Saito, K., Kameyama, Y., Ueno, K., Izawa, M., Okuda, N., Suzuki, H., Harasawa, T., Nasu, M., Takada, T., Ito, F., Nunomiya, S., Koyama, K., Abe, T., Andoh, K., Kusumoto, K., Hirata, A., Takaba, A., Kimura, H., Matsumoto, S., Higashijima, U., Honda, H., Aoki, N., Imai, H., Ogino, Y., Mizuguchi, I., Ichikado, K., Nitta, K., Mochizuki, K., Hashida, T., Tanaka, H., Nakamura, T., Niimi, D., Ueda, T., Kashiwa, Y., Uchiyama, A., Sabelnikovs, O., Oss, P., Haddad, Y., Liew, K. Y., Namendys-Silva, S. A., Jarquin-Badiola, Y. D., Sanchez-Hurtado, L. A., Gomez-Flores, S. S., Marin, M. C., Villagomez, A. J., Lemus, J. S., Fierro, J. M., Cervantes, M. R., Mejia, F. J. F., Dector, D., Dector, D. M., Gonzalez, D. R., Estrella, C. R., Sanchez-Medina, J. R., Ramirez-Gutierrez, A., George, F. G., Aguirre, J. S., Buensuseso, J. A., Poblano, M., University, M. V., Dendane, T., Balkhi, H., Elkhayari, M., Samkaoui, N., Ezzouine, H., Benslama, A., Amor, M., Maazouzi, W., Cimic, N., Beck, O., Bruns, M. M., Schouten, J. A., Rinia, M., Raaijmakers, M., Van Wezel, H. M., Heines, S. J., Strauch, U., Buise, M. P., Simonis, F. D., Schultz, M. J., Goodson, J. C., Browne, T. S., Navarra, L., Hunt, A., Hutchison, R. A., Bailey, M. B., Newby, L., Mcarthur, C., Kalkoff, M., Mcleod, A., Casement, J., Hacking, D. J., Andersen, F. H., Dolva, M. S., Barratt-Due, A., Noremark, K. A. L., Soreide, E., Sjobo, B. A., Guttormsen, A. B., Yoshido, H. H. L., Aguilar, R. Z., Oscanoa, F. A. M., Alisasis, A. U., Robles, J. B., Pasanting-Lim, R. A. B., Tan, B. C., Andruszkiewicz, P., Jakubowska, K., Coxo, C. M., Alvarez, A. M., Oliveira, B. S., Montanha, G. M., Barros, N. C., Pereira, C. S., Messias, A. M., Monteiro, J. M., Araujo, A. M., Catorze, N. T., Marum, S. M., Bouw, M. J., Gomes, R. M., Brito, V. A., Castro, S., Estilita, J. M., Barros, F. M., Serra, I. M., Martinho, A. M., Tomescu, D. R., Marcu, A., Bedreag, O. H., Papurica, M., Corneci, D. E., Negoita, S. I., Grigoriev, E., Gritsan, A. I., Gazenkampf, A. A., Almekhlafi, G., Albarrak, M. M., Mustafa, G. M., Maghrabi, K. A., Salahuddin, N., Aisa, T. M., Al Jabbary, A. S., Tabhan, E., Arabi, Y. M., Trinidad, O. A., Al Dorzi, H. M., Tabhan, E. E., Bolon, S., Smith, O., Mancebo, J., Aguirre-Bermeo, H., Lopez-Delgado, J. C., Esteve, F., Rialp, G., Forteza, C., De Haro, C., Artigas, A., Albaiceta, G. M., De Cima-Iglesias, S., Seoane-Quiroga, L., Ceniceros-Barros, A., Ruiz-Aguilar, A. L., Claraco-Vega, L. M., Soler, J. A., del Carmen Lorente, M., Hermosa, C., Gordo, F., Prieto-Gonzalez, M., Lopez-Messa, J. B., Perez, M. P., Perez, C. P., Allue, R. M., Roche-Campo, F., Ibanez-Santacruz, M., Temprano, S., Pintado, M. C., De Pablo, R., Gomez, P. R. A., Ruiz, S. R., Moles, S. I., Jurado, M. ªT., Arizmendi, A., Piacentini, E. A., Franco, N., Honrubia, T., Cheng, M. P., Losada, E. P., Blanco, J., Yuste, L. J., Carbayo-Gorriz, C., Cazorla-Barranquero, F. G., Alonso, J. G., Alda, R. S., Algaba, A., Navarro, G., Cereijo, E., Diaz-Rodriguez, E., Marcos, D. P., Montero, L. A., Para, L. H., Sanchez, R. J., Navalpotro, M. A. B., Abad, R. D., Lez, R. M. G. A., Toribio, D. P., Castro, A. G., Artiga, M. J. D., Penuelas, O., Roser, T. P., Olga, M. F., Curto, E. G., Sanchez, R. M., Imma, V. P., Elisabet, G. M., Claverias, L., Magret, M., Pellicer, A. M., Rodriguez, L. L., Sanchez-Ballesteros, J., Gonzalez-Salamanca, A., Jimenez, A. G., Huerta, F. P., Diaz, J. C. J. S., Lopez, E. B., Moya, D. D. L., Alfonso, A. A. T., Luis, P. S. E., Cesar, P. S., Rafael, S. I., Virgilio, C. G., Recio, N. N., Adamsson, R. O., Rylander, C. C., Holzgraefe, B., Broman, L. M., Wessbergh, J., Persson, L., Schioler, F., Kedelv, H., Tibblin, A. O., Appelberg, H., Hedlund, L., Helleberg, J., Eriksson, K. E., Glietsch, R., Larsson, N., Nygren, I., Nunes, S. L., Morin, A. -K., Kander, T., Adolfsson, A., Zender, H. O., Leemann-Refondini, C., Elatrous, S., Bouchoucha, S., Chouchene, I., Ouanes, I., Marsa, L., Souissi, A. B., Kamoun, S., Demirkiran, O., Aker, M., Erbabacan, E., Ceylan, I., Girgin, N. K., Ozcelik, M., Unal, N., Meco, B. C., Akyol, O. O., Derman, S. S., Kennedy, B., Parhar, K., Srinivasa, L., Mcauley, D., Hopkins, P., Mellis, C., Kakar, V., Hadfield, D., Vercueil, A., Bhowmick, K., Humphreys, S. K., Ferguson, A., Mckee, R., Raj, A. S., Fawkes, D. A., Watt, P., Twohey, L., Thomas, R. R. J. M., Morton, A., Kadaba, V., Smith, M. J., Hormis, A. P., Kannan, S. G., Namih, M., Reschreiter, H., Camsooksai, J., Kumar, A., Rugonfalvi, S., Nutt, C., Oneill, O., Seasman, C., Dempsey, G., Scott, C. J., Ellis, H. E., Mckechnie, S., Hutton, P. J., Di Tomasso, N. N., Vitale, M. N., Griffin, R. O., Dean, M. N., Cranshaw, J. H., Willett, E. L., Ioannou, N., Gillis, S., Csabi, P., Macfadyen, R., Dawson, H., Preez, P. D., Williams, A. J., Boyd, O., De Gordoa, L. O. -R., Bramall, J., Symmonds, S., Chau, S. K., Wenham, T., Szakmany, T., Toth-Tarsoly, P., Mccalman, K. H., Alexander, P., Stephenson, L., Collyer, T., Chapman, R., Cooper, R., Allan, R. M., Sim, M., Wrathall, D. W., Irvine, D. A., Zantua, K. S., Adams, J. C., Burtenshaw, A. J., Sellors, G. P., Welters, I. D., Williams, K. E., Hessell, R. J., Oldroyd, M. G., Battle, C. E., Pillai, S., Kajtor, I., Sivashanmugavel, M., Okane, S. C., Donnelly, A., Frigyik, A. D., Careless, J. P., May, M. M., Stewart, R., Trinder, T. J., Hagan, S. J., Wise, M. P., Cole, J. M., Macfie, C. C., Dowling, A. T., Nunez, E., Pittini, G., Rodriguez, R., Imperio, M. C., Santos, C., Deicas, A., Serra, C., Uppalapati, A., Kamel, G., Banner-Goodspeed, V. M., Beitler, J. R., Mukkera, S. R., Kulkarni, S., Lee, J., Mesar, T., Shinn Iii, J. O., Gomaa, D., Tainter, C., Yeatts, D. J., Warren, J., Lanspa, M. J., Miller, R. R., Grissom, C. K., Brown, S. M., Bauer, P. R., Gosselin, R. J., Kitch, B. T., Cohen, J. E., Beegle, S. H., Gueret, R. M., Tulaimat, A., Choudry, S., Stigler, W., Batra, H., Huff, N. G., Lamb, K. D., Oetting, T. W., Mohr, N. M., Judy, C., Saito, S., Kheir, F. M., Kheir, F., Schlichting, A. B., Delsing, A., Crouch, D. R., Elmasri, M., Ismail, D., Dreyer, K. R., Blakeman, T. C., Baron, R. M., Grijalba, C. Q., Hou, P. C., Seethala, R., Aisiku, I., Henderson, G., Frendl, G., Hou, S. -K., Owens, R. L., Schomer, A., Bumbasirevic, V., Jovanovic, B., Surbatovic, M., Veljovic, M., UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, UCL - (SLuc) Service de soins intensifs, Investigators, LUNG SAFE, Group, ESICM Trials, Madotto, F, Mcnicholas, B, Rezoagli, E, Pham, T, Laffey, J, Bellani, G, Pesenti, A, Brochard, L, Esteban, A, Gattinoni, L, van Haren, F, Ranieri, M, Rubenfeld, G, Thompson, B, Slutsky, A, Rios, F, Faruq, M, Sottiaux, T, Depuydt, P, Lora, F, Azevedo, C, Fan, E, Bugedo, G, Qiu, H, Gonzalez, M, Silesky, J, Cerny, V, Nielsen, J, Jibaja, M, Wrigge, H, Matamis, D, Ranero, J, Gomersall, C, Amin, P, Hashemian, S, Clarkson, K, Kurahashi, K, Koh, Y, Villagomez, A, Zeggwagh, A, Heunks, L, Laake, J, Kashif, W, Synclair, J, Palo, J, do Vale Fernandes, A, Sandesc, D, Arabi, Y, Bumbasierevic, V, Nin, N, Lorente, J, Larsson, A, Piquilloud, L, Patjanasoontorn, B, Abroug, F, Mcauley, D, Mcnamee, L, Hurtado, J, Bajwa, E, Dempaire, G, Francois, G, 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Poli, M, Raimondi, F, Albiero, D, Crapelli, G, Beck, E, Pota, V, Schiavone, V, Molin, A, Tarantino, F, Monti, G, Frati, E, Mirabella, L, Cinnella, G, Fossali, T, Colombo, R, Pattarino, P, Mojoli, F, Braschi, A, Borotto, E, Cracchiolo, A, Palma, D, Raponi, F, Foti, G, Vascotto, E, Coppadoro, A, Brazzi, L, Floris, L, Iotti, G, Venti, A, Yamaguchi, O, Takagi, S, Maeyama, H, Watanabe, E, Yamaji, Y, Shimizu, K, Shiozaki, K, Futami, S, Ryosuke, S, Saito, K, Kameyama, Y, Ueno, K, Izawa, M, Okuda, N, Suzuki, H, Harasawa, T, Nasu, M, Takada, T, Ito, F, Nunomiya, S, Koyama, K, Abe, T, Andoh, K, Kusumoto, K, Hirata, A, Takaba, A, Kimura, H, Matsumoto, S, Higashijima, U, Honda, H, Aoki, N, Imai, H, Ogino, Y, Mizuguchi, I, Ichikado, K, Nitta, K, Mochizuki, K, Hashida, T, Tanaka, H, Nakamura, T, Niimi, D, Ueda, T, Kashiwa, Y, Uchiyama, A, Sabelnikovs, O, Oss, P, Haddad, Y, Liew, K, Namendys-Silva, S, Jarquin-Badiola, Y, Sanchez-Hurtado, L, Gomez-Flores, S, Marin, M, Lemus, J, Fierro, J, Cervantes, 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M, Corneci, D, Negoita, S, Grigoriev, E, Gritsan, A, Gazenkampf, A, Almekhlafi, G, Albarrak, M, Mustafa, G, Maghrabi, K, Salahuddin, N, Aisa, T, Al Jabbary, A, Tabhan, E, Trinidad, O, Al Dorzi, H, Bolon, S, Smith, O, Mancebo, J, Aguirre-Bermeo, H, Lopez-Delgado, J, Esteve, F, Rialp, G, Forteza, C, De Haro, C, Artigas, A, Albaiceta, G, De Cima-Iglesias, S, Seoane-Quiroga, L, Ceniceros-Barros, A, Ruiz-Aguilar, A, Claraco-Vega, L, Soler, J, del Carmen Lorente, M, Hermosa, C, Gordo, F, Prieto-Gonzalez, M, Lopez-Messa, J, Perez, M, Perez, C, Allue, R, Roche-Campo, F, Ibanez-Santacruz, M, Temprano, S, Pintado, M, De Pablo, R, Ruiz, S, Moles, S, Jurado, M, Arizmendi, A, Piacentini, E, Franco, N, Honrubia, T, Cheng, M, Losada, E, Blanco, J, Yuste, L, Carbayo-Gorriz, C, Cazorla-Barranquero, F, Alonso, J, Alda, R, Algaba, A, Navarro, G, Cereijo, E, Diaz-Rodriguez, E, Marcos, D, Montero, L, Para, L, Sanchez, R, Navalpotro, M, Abad, R, Lez, R, Toribio, D, Castro, A, Artiga, M, Penuelas, O, Roser, T, Olga, M, Curto, E, Imma, V, Elisabet, G, Claverias, L, Magret, M, Pellicer, A, Rodriguez, L, Sanchez-Ballesteros, J, Gonzalez-Salamanca, A, Jimenez, A, Huerta, F, Diaz, J, Lopez, E, Moya, D, Alfonso, A, Luis, P, Cesar, P, Rafael, S, Virgilio, C, Recio, N, Adamsson, R, Rylander, C, Holzgraefe, B, Broman, L, Wessbergh, J, Persson, L, Schioler, F, Kedelv, H, Tibblin, A, Appelberg, H, Hedlund, L, Helleberg, J, Eriksson, K, Glietsch, R, Larsson, N, Nygren, I, Nunes, S, Morin, A, Kander, T, Adolfsson, A, Zender, H, Leemann-Refondini, C, Elatrous, S, Bouchoucha, S, Chouchene, I, Ouanes, I, Marsa, L, Souissi, A, Kamoun, S, Demirkiran, O, Aker, M, Erbabacan, E, Ceylan, I, Girgin, N, Ozcelik, M, Unal, N, Meco, B, Akyol, O, Derman, S, Kennedy, B, Parhar, K, Srinivasa, L, Hopkins, P, Mellis, C, Kakar, V, Hadfield, D, Vercueil, A, Bhowmick, K, Humphreys, S, Ferguson, A, Mckee, R, Raj, A, Fawkes, D, Watt, P, Twohey, L, Thomas, R, Morton, A, Kadaba, V, Smith, M, Hormis, A, Kannan, S, Namih, M, 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Vladimir Cerny, Jonas Nielsen, Manuel Jibaja, Tài Pham, Hermann Wrigge, Dimitrios Matamis, Jorge Luis Ranero, Charles Gomersall, Pravin Amin, S M Hashemian, Kevin Clarkson, Giacomo Bellani, Kiyoyasu Kurahashi, Younsuck Koh, Asisclo Villagomez, Amine Ali Zeggwagh, Leo M Heunks, Jon Henrik Laake, Waqar Kashif, Jorge Synclair, Jose Emmanuel Palo, Antero do Vale Fernandes, Dorel Sandesc, Yaasen Arabi, Vesna Bumbasierevic, Nicolas Nin, Jose A Lorente, Anders Larsson, Lise Piquilloud, Boonsong Patjanasoontorn, Fekri Abroug, Daniel F McAuley, Lia McNamee, Javier Hurtado, Ed Bajwa, Gabriel Démpaire, Guy M Francois, Francesca Rabboni, Fabiana Madotto, Sara Conti, Hektor Sula, Lordian Nunci, Alma Cani, Alan Zazu, Christian Dellera, Carolina S Insaurralde, Risso V Alejandro, Julio Daldin, Mauricio Vinzio, Ruben O Fernandez, Luis P Cardonnet, Lisandro R Bettini, Mariano Carboni Bisso, Emilio M Osman, Mariano G Setten, Pablo Lovazzano, Javier Alvarez, Veronica Villar, Norberto C Pozo, Nicolas 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Daniel V Collins, Wahid Altaf, Gianluca Zani, Maurizio Fusari, Savino Spadaro, Carlo A Volta, Romano Graziani, Barbara Brunettini, Salvatore Palmese, Paolo Formenti, Michele Umbrello, Andrea Lombardo, Elisabetta Pecci, Marco Botteri, Monica Savioli, Alessandro Protti, Alessia Mattei, Lorenzo Schiavoni, Andrea Tinnirello, Manuel Todeschini, Antonino Giarratano, Andrea Cortegiani, Sara Sher, Anna Rossi, Massimo M Antonelli, Luca M Montini, Paolo Casalena, Sergio Scafetti, Giovanna Panarello, Giovanna Occhipinti, Nicolò Patroniti, Matteo Pozzi, Roberto R Biscione, Michela M Poli, Ferdinando Raimondi, Daniela Albiero, Giulia Crapelli, Eduardo Beck, Vincenzo Pota, Vincenzo Schiavone, Alexandre Molin, Fabio Tarantino, Giacomo Monti, Elena Frati, Lucia Mirabella, Gilda Cinnella, Tommaso Fossali, Riccardo Colombo, Pierpaolo Terragni Ilaria Pattarino, Francesco Mojoli, Antonio Braschi, Erika E Borotto, Andrea N Cracchiolo, Daniela M Palma, Francesco Raponi, Giuseppe Foti, Ettore R Vascotto, Andrea Coppadoro, Luca Brazzi, Leda Floris, Giorgio A Iotti, Aaron Venti, Osamu Yamaguchi, Shunsuke Takagi, Hiroki N Maeyama, Eizo Watanabe, Yoshihiro Yamaji, Kazuyoshi Shimizu, Kyoko Shiozaki, Satoru Futami, Sekine Ryosuke, Koji Saito, Yoshinobu Kameyama, Keiko Ueno, Masayo Izawa, Nao Okuda, Hiroyuki Suzuki, Tomofumi Harasawa, Michitaka Nasu, Tadaaki Takada, Fumihito Ito, Shin Nunomiya, Kansuke Koyama, Toshikazu Abe, Kohkichi Andoh, Kohei Kusumoto, Akira Hirata, Akihiro Takaba, Hiroyasu Kimura, Shuhei Matsumoto, Ushio Higashijima, Hiroyuki Honda, Nobumasa Aoki, Hiroshi Imai, Yasuaki Ogino, Ichiko Mizuguchi, Kazuya Ichikado, Kenichi Nitta, Katsunori Mochizuki, Tomoaki Hashida, Hiroyuki Tanaka, Tomoyuki Nakamura, Daisuke Niimi, Takeshi Ueda, Yozo Kashiwa, Akinori Uchiyama, Olegs Sabelnikovs, Peteris Oss, Youssef Haddad, Kong Y Liew, Silvio A Ñamendys-Silva, Yves D Jarquin-Badiola, Luis A Sanchez-Hurtado, Saira S Gomez-Flores, Maria C Marin, Asisclo J Villagomez, Jordana S Lemus, Jonathan M Fierro, Mavy Ramirez Cervantes, Francisco Javier Flores Mejia, Dulce Dector, Dulce M Dector, Daniel R Gonzalez, Claudia R Estrella, Jorge R Sanchez-Medina, Alvaro Ramirez-Gutierrez, Fernando G George, Janet S Aguirre, Juan A Buensuseso, Manuel Poblano, Mohammed V University, Tarek Dendane, Amine Ali Zeggwagh, Hicham Balkhi, Mina Elkhayari, Nacer Samkaoui, Hanane Ezzouine, Abdellatif Benslama, Mourad Amor, Wajdi Maazouzi, Nedim Cimic, Oliver Beck, Monique M Bruns, Jeroen A Schouten, Myra Rinia, Monique Raaijmakers, Leo M Heunks, Hellen M Van Wezel, Serge J Heines, Ulrich Strauch, Marc P Buise, Fabienne D Simonis, Marcus J Schultz, Jennifer C Goodson, Troy S Browne, Leanlove Navarra, Anna Hunt, Robyn A Hutchison, Mathew B Bailey, Lynette Newby, Colin Mcarthur, Michael Kalkoff, Alex Mcleod, Jonathan Casement, Danielle J Hacking, Finn H Andersen, Merete S Dolva, Jon H Laake, Andreas Barratt-Due, Kim Andre L Noremark, Eldar Søreide, Brit Å Sjøbø, Anne B Guttormsen, Hector H Leon Yoshido, Ronald Zumaran Aguilar, Fredy A Montes Oscanoa, Alain U Alisasis, Joanne B Robles, Rossini Abbie B Pasanting-Lim, Beatriz C Tan, Pawel Andruszkiewicz, Karina Jakubowska, Cristina M Coxo, António M Alvarez, Bruno S Oliveira, Gustavo M Montanha, Nelson C Barros, Carlos S Pereira, António M Messias, Jorge M Monteiro, Ana M Araujo, Nuno T Catorze, Susan M Marum, Maria J Bouw, Rui M Gomes, Vania A Brito, Silvia Castro, Joana M Estilita, Filipa M Barros, Isabel M Serra, Aurelia M Martinho, Dana R Tomescu, Alexandra Marcu, Ovidiu H Bedreag, Marius Papurica, Dan E Corneci, Silvius Ioan Negoita, Evgeny Grigoriev, Alexey I Gritsan, Andrey A Gazenkampf, Ghaleb Almekhlafi, Mohamad M Albarrak, Ghanem M Mustafa, Khalid A Maghrabi, Nawal Salahuddin, Tharwat M Aisa, Ahmed S Al Jabbary, Edgardo Tabhan, Yaseen M Arabi, Olivia A Trinidad, Hasan M Al Dorzi, Edgardo E Tabhan, Stefan Bolon, Oliver Smith, Jordi Mancebo, Hernan Aguirre-Bermeo, Juan C Lopez-Delgado, Francisco Esteve, Gemma Rialp, Catalina Forteza, Candelaria De Haro, Antonio Artigas, Guillermo M Albaiceta, Sara De Cima-Iglesias, Leticia Seoane-Quiroga, Alexandra Ceniceros-Barros, Antonio L Ruiz-Aguilar, Luis M Claraco-Vega, Juan Alfonso Soler, Maria Del Carmen Lorente, Cecilia Hermosa, Federico Gordo, Miryam Prieto-González, Juan B López-Messa, Manuel P Perez, Cesar P Perez, Raquel Montoiro Allue, Ferran Roche-Campo, Marcos Ibañez-Santacruz, Susana Temprano, Maria C Pintado, Raul De Pablo, Pilar Ricart Aroa Gómez, Silvia Rodriguez Ruiz, Silvia Iglesias Moles, Mª Teresa Jurado, Alfons Arizmendi, Enrique A Piacentini, Nieves Franco, Teresa Honrubia, Meisy Perez Cheng, Elena Perez Losada, Javier Blanco, Luis J Yuste, Cecilia Carbayo-Gorriz, Francisca G Cazorla-Barranquero, Javier G Alonso, Rosa S Alda, Ángela Algaba, Gonzalo Navarro, Enrique Cereijo, Esther Diaz-Rodriguez, Diego Pastor Marcos, Laura Alvarez Montero, Luis Herrera Para, Roberto Jimenez Sanchez, Miguel Angel Blasco Navalpotro, Ricardo Diaz Abad, Raquel Montiel Gonz Á Lez, Dácil Parrilla Toribio, Alejandro G Castro, Maria Jose D Artiga, Oscar Penuelas, Tomas P Roser, Moreno F Olga, Elena Gallego Curto, Rocío Manzano Sánchez, Vallverdu P Imma, Garcia M Elisabet, Laura Claverias, Monica Magret, Ana M Pellicer, Lucia L Rodriguez, Jesús Sánchez-Ballesteros, Ángela González-Salamanca, Antonio G Jimenez, Francisco P Huerta, Juan Carlos J Sotillo Diaz, Esther Bermejo Lopez, David D Llinares Moya, Alec A Tallet Alfonso, Palazon Sanchez Eugenio Luis, Palazon Sanchez Cesar, Sánchez I Rafael, Corcoles G Virgilio, Noelia N Recio, Richard O Adamsson, Christian C Rylander, Bernhard Holzgraefe, Lars M Broman, Joanna Wessbergh, Linnea Persson, Fredrik Schiöler, Hans Kedelv, Anna Oscarsson Tibblin, Henrik Appelberg, Lars Hedlund, Johan Helleberg, Karin E Eriksson, Rita Glietsch, Niklas Larsson, Ingela Nygren, Silvia L Nunes, Anna-Karin Morin, Thomas Kander, Anne Adolfsson, Lise Piquilloud, Hervé O Zender, Corinne Leemann-Refondini, Souheil Elatrous, Slaheddine Bouchoucha, Imed Chouchene, Islem Ouanes, La Marsa, Asma Ben Souissi, Salma Kamoun, Oktay Demirkiran, Mustafa Aker, Emre Erbabacan, Ilkay Ceylan, Nermin Kelebek Girgin, Menekse Ozcelik, Necmettin Ünal, Basak Ceyda Meco, Onat O Akyol, Suleyman S Derman, Barry Kennedy, Ken Parhar, Latha Srinivasa, Lia McNamee, Danny McAuley, Phil Hopkins, Clare Mellis, Vivek Kakar, Dan Hadfield, Andre Vercueil, Kaushik Bhowmick, Sally K Humphreys, Andrew Ferguson, Raymond Mckee, Ashok S Raj, Danielle A Fawkes, Philip Watt, Linda Twohey, Rajeev R JhaMatthew Thomas, Alex Morton, Varsha Kadaba, Mark J Smith, Anil P Hormis, Santhana G Kannan, Miriam Namih, Henrik Reschreiter, Julie Camsooksai, Alek Kumar, Szabolcs Rugonfalvi, Christopher Nutt, Orla Oneill, Colette Seasman, Ged Dempsey, Christopher J Scott, Helen E Ellis, Stuart Mckechnie, Paula J Hutton, Nora N Di Tomasso, Michela N Vitale, Ruth O Griffin, Michael N Dean, Julius H Cranshaw, Emma L Willett, Nicholas Ioannou, Sarah Gillis, Peter Csabi, Rosaleen Macfadyen, Heidi Dawson, Pieter D Preez, Alexandra J Williams, Owen Boyd, Laura Ortiz-Ruiz De Gordoa, Jon Bramall, Sophie Symmonds, Simon K Chau, Tim Wenham, Tamas Szakmany, Piroska Toth-Tarsoly, Katie H Mccalman, Peter Alexander, Lorraine Stephenson, Thomas Collyer, Rhiannon Chapman, Raphael Cooper, Russell M Allan, Malcolm Sim, David W Wrathall, Donald A Irvine, Kim S Zantua, John C Adams, Andrew J Burtenshaw, Gareth P Sellors, Ingeborg D Welters, Karen E Williams, Robert J Hessell, Matthew G Oldroyd, Ceri E Battle, Suresh Pillai, Istvan Kajtor, Mageswaran Sivashanmugavel, Sinead C Okane, Adrian Donnelly, Aniko D Frigyik, Jon P Careless, Martin M May, Richard Stewart, T John Trinder, Samantha J Hagan, Matt P Wise, Jade M Cole, Caroline C MacFie, Anna T Dowling, Javier Hurtado, Nicolás Nin, Javier Hurtado, Edgardo Nuñez, Gustavo Pittini, Ruben Rodriguez, María C Imperio, Cristina Santos, Alberto Deicas, Carolina Serra, Aditya Uppalapati, Ghassan Kamel, Valerie M Banner-Goodspeed, Jeremy R Beitler, Satyanarayana Reddy Mukkera, Shreedhar Kulkarni, Jarone Lee, Tomaz Mesar, John O Shinn Iii, Dina Gomaa, Christopher Tainter, Jarone Lee, Tomaz Mesar, Jarone Lee, Dale J Yeatts, Jessica Warren, Michael J Lanspa, Russel R Miller, Colin K Grissom, Samuel M Brown, Philippe R Bauer, Ryan J Gosselin, Barrett T Kitch, Jason E Cohen, Scott H Beegle, Renaud M Gueret, Aiman Tulaimat, Shazia Choudry, William Stigler, Hitesh Batra, Nidhi G Huff, Keith D Lamb, Trevor W Oetting, Nicholas M Mohr, Claine Judy, Shigeki Saito, Fayez M Kheir, Fayez Kheir, Adam B Schlichting, Angela Delsing, Daniel R Crouch, Mary Elmasri, Daniel R Crouch, Dina Ismail, Kyle R Dreyer, Thomas C Blakeman, Kyle R Dreyer, Dina Gomaa, Rebecca M Baron, Carolina Quintana Grijalba, Peter C Hou, Raghu Seethala, Imo Aisiku, Galen Henderson, Gyorgy Frendl, Sen-Kuang Hou, Robert L Owens, Ashley Schomer, Vesna Bumbasirevic, Bojan Jovanovic, Maja Surbatovic, Milic Veljovic, John G Laffey, Giacomo Bellani, Antonio Pesenti
Subjects: Male, ARDS, LUNG SAFE, health care facilities, manpower, and services, Acute hypoxemic respiratory failure, Acute respiratory distress syndrome, Hospital survival, ICU discharge, Kaplan-Meier Estimate, Critical Care and Intensive Care Medicine, 0302 clinical medicine, Risk Factors, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, COPD, Medical emergencies. Critical care. Intensive care. First aid, Middle Aged, Patient Discharge, Intensive Care Units, medicine.anatomical_structure, Lung safe, SOFA score, Female, Respiratory Insufficiency, Adult, medicine.medical_specialty, NO, 03 medical and health sciences, Settore MED/41 - ANESTESIOLOGIA, medicine, Humans, ddc:610, Risk factor, Mortality, Aged, Lung, RC86-88.9, business.industry, Research, 030208 emergency & critical care medicine, medicine.disease, Logistic Models, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Respiratory failure, Emergency medicine, Observational study, business
Abstract: Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073.
Published: 2021

29. Tepotinib in patients with NSCLC harbouring MET exon 14 skipping: Japanese subset analysis from the Phase II VISION study

Author: Rolf Bruns, Tomohiro Sakamoto, Takaaki Tokito, J. Straub, Hiroaki Takeoka, Hiroshi Tanaka, Naofumi Shinagawa, Shinji Atagi, Toshiyuki Kozuki, Kenichi Chikamori, Terufumi Kato, Paul K. Paik, Toru Kumagai, Hiroshi Sakai, Karl Maria Schumacher, Shingo Matsumoto, and Masahiro Morise
Subjects: Male, 0301 basic medicine, Oncology, Cancer Research, Lung Neoplasms, Peripheral edema, carcinoma, Proto-Oncogene Mas, 0302 clinical medicine, Japan, Piperidines, Quality of life, Carcinoma, Non-Small-Cell Lung, Clinical endpoint, tepotinib, Aged, 80 and over, Exons, General Medicine, Middle Aged, Proto-Oncogene Proteins c-met, Pyridazines, 030220 oncology & carcinogenesis, Female, Original Article, medicine.symptom, Subset Analysis, medicine.medical_specialty, Antineoplastic Agents, 03 medical and health sciences, Clinical Trials, Phase II as Topic, Internal medicine, medicine, Carcinoma, Humans, AcademicSubjects/MED00300, Radiology, Nuclear Medicine and imaging, Liquid biopsy, Adverse effect, Protein Kinase Inhibitors, Aged, Retrospective Studies, liquid biopsy, business.industry, medicine.disease, Confidence interval, Pyrimidines, non-small-cell lung, 030104 developmental biology, Mutation, Quality of Life, business
Abstract: Background MET exon 14 skipping is an oncogenic driver occurring in 3–4% of non-small cell lung cancer (NSCLC). The MET inhibitor tepotinib has demonstrated clinical efficacy in patients with MET exon 14 skipping NSCLC. Here, we present data from Japanese patients in the Phase II VISION study, evaluating the efficacy and safety of tepotinib. Methods In the open-label, single-arm, Phase II VISION study, patients with advanced/metastatic NSCLC with MET exon 14 skipping received oral tepotinib 500 mg once daily. The primary endpoint was objective response by independent review. Subgroup analyses of Japanese patients were preplanned. Results As of 1 January 2020, 19 Japanese patients received tepotinib and were evaluated for safety, 15 of whom had ≥9 months’ follow-up and were also analysed for efficacy. By independent review, objective response rate (ORR) was 60.0% (95% confidence interval [CI]: 32.3, 83.7), median duration of response was not reached (95% CI: 6.9, not estimable [ne]), and progression-free survival was 11.0 months (95% CI: 1.4, ne). ORR in patients with MET exon 14 skipping identified by liquid biopsy (n = 8) was 87.5% (95% CI: 47.3, 99.7), and by tissue biopsy (n = 12) was 50.0% (95% CI: 21.1, 78.9). Patients’ quality of life was maintained with tepotinib treatment. Among patients evaluated for safety, the most common treatment-related adverse events (any grade) were blood creatinine increase and peripheral oedema (12 and nine patients, respectively). Conclusions Tepotinib demonstrated robust and durable clinical efficacy in Japanese patients with advanced NSCLC harbouring MET exon 14 skipping, identified by either liquid or tissue biopsy. The main adverse events, blood creatinine increase and peripheral oedema, were manageable., In VISION, tepotinib demonstrated robust efficacy in Japanese patients with MET exon 14 skipping NSCLC. The safety profile was tolerable, with mostly mild–moderate adverse events and few treatment discontinuations.
Published: 2021
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30. Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma

Author: Aylin Pamuk, Wolfgang Schroeder, Jan Rehkaemper, Hakan Alakus, Thomas Zander, Reinhard Buettner, Atakan Görkem Barutcu, Josef Rueschoff, Heike Löser, Sebastian Klein, Christiane Bruns, Jennifer Quantius, Alexander Quaas, Birgid Schoemig-Markiefka, Axel M. Hillmer, and Florian Gebauer
Subjects: Male, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, Neutrophils, medicine.medical_treatment, Stomach neoplasms, Subgroup analysis, Adenocarcinoma, GPI-Linked Proteins, Gastroenterology, Cohort Studies, Antigens, CD, Surgical oncology, Germany, Internal medicine, medicine, Humans, Esophagus, Neoadjuvant therapy, Tumor microenvironment, business.industry, Gender, Gender Identity, Cancer, General Medicine, Middle Aged, Esophageal cancer, Prognosis, medicine.disease, Combined Modality Therapy, Survival Analysis, Neoadjuvant Therapy, medicine.anatomical_structure, Oncology, Cohort, Original Article, Female, business, Cell Adhesion Molecules
Abstract: Background Tumor-associated neutrophils (TANs) have recently been identified as a relevant component of the tumor microenvironment (TME) in solid tumors. Within the TME TANs mediate either tumor-promoting or tumor-inhibiting activities. So far, their prognostic relevance remains to be determined. This study aims to evaluate the prognostic relevance of TANs in different molecular subtypes of gastric and esophageal adenocarcinoma. Methods We analyzed a total of 1118 Caucasian patients divided into gastric adenocarcinoma (n = 458) and esophageal adenocarcinoma cohort (n = 660) of primarily resected and neoadjuvant-treated individuals. The amount of CD66b + TANs in the tumor stroma was determined using quantitative image analysis and correlated to both molecular, as well as clinical data. Results An accumulation of TANs in the tumor stroma of gastric carcinomas was associated to a significant favorable prognosis (p = 0.026). A subgroup analysis showed that this effect was primarily related to the molecular chromosomal instable subtype (CIN) of gastric carcinomas (p = 0.010). This was only observed in female patients (p = 0.014) but not in male patients (p = 0.315). The same sex-specific effect could be confirmed in adenocarcinomas of the esophagus (p = 0.027), as well as in female individuals after receiving neoadjuvant therapy (p = 0.034). Conclusions Together, we show a sex-specific prognostic effect of TANs in gastric cancer within a Caucasian cohort. For the first time, we showed that this sex-specific prognostic effect of TANs can also be seen in esophageal cancer.
Published: 2021
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31. Cardiac response to adrenergic stress differs by sex and across the lifespan

Author: Danielle R. Bruns, Jacob M Zumo, Ross F. Cook, Aykhan Yusifov, Emily E. Schmitt, Kathleen C. Woulfe, Benjamin McNair, and Vikram E. Chhatre
Subjects: Male, Cardiac function curve, Aging, medicine.medical_specialty, Longevity, Adrenergic, Muscle hypertrophy, Mice, Adrenergic Agents, Fibrosis, Internal medicine, Heart rate, medicine, Animals, Juvenile, Myocytes, Cardiac, Ejection fraction, business.industry, Isoproterenol, Adrenergic beta-Agonists, medicine.disease, medicine.anatomical_structure, Endocrinology, Ventricle, Female, Original Article, Geriatrics and Gerontology, business
Abstract: The aging heart is well-characterized by a diminished responsiveness to adrenergic activation. However, the precise mechanisms by which age and sex impact adrenergic-mediated cardiac function remain poorly described. In the current investigation, we compared the cardiac response to adrenergic stress to gain mechanistic understanding of how the response to an adrenergic challenge differs by sex and age. Juvenile (4 weeks), adult (4–6 months), and aged (18–20 months) male and female mice were treated with the β-agonist isoproterenol (ISO) for 1 week. ISO-induced morphometric changes were age- and sex-dependent as juvenile and adult mice of both sexes had higher left ventricle weights while aged mice did not increase cardiac mass. Adults increased myocyte cell size and deposited fibrotic matrix in response to ISO, while juvenile and aged animals did not show evidence of hypertrophy or fibrosis. Juvenile females and adults underwent expected changes in systolic function with higher heart rate, ejection fraction, and fractional shortening. However, cardiac function in aged animals was not altered in response to ISO. Transcriptomic analysis identified significant differences in gene expression by age and sex, with few overlapping genes and pathways between groups. Fibrotic and adrenergic signaling pathways were upregulated in adult hearts. Juvenile hearts upregulated genes in the adrenergic pathway with few changes in fibrosis, while aged mice robustly upregulated fibrotic gene expression without changes in adrenergic genes. We suggest that the response to adrenergic stress significantly differs across the lifespan and by sex. Mechanistic definition of these age-related pathways by sex is critical for future research aimed at treating age-related cardiac adrenergic desensitization. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-021-00345-x.
Published: 2021
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32. Distal Radius Fractures in Patients Aged 50 Years or Older: Obstacles to Bone Health Analysis and Follow-Up in a Community Setting

Author: Rachel Talley-Bruns, Haik Kavookjian, Rachel Silverstein, Michael Brownstein, Alexander Lundy, and Sonya Khurana
Subjects: Pediatrics, medicine.medical_specialty, Medical treatment, Chemical treatment, business.industry, Osteoporosis, Evidence-based medicine, medicine.disease, Bone health, Quality of life, medicine, Community setting, Surgery, In patient, business
Abstract: Purpose To determine barriers to implementing an osteoporosis protocol in a community institution following distal radius (DR) fragility fracture to help prevent subsequent fragility fractures. Methods This cross-sectional study included elderly patients with DR fractures that occurred between 2016 and 2018. Exclusion criteria were age under 50 years, high-energy mechanism, and inability to follow-up locally. Patients were directed to follow-up with the hospital’s osteoporosis center (OC) or an endocrinologist. Patients were contacted to identify if care was established with the OC and screened for potential barriers in evaluation for bone health. Primary outcomes included the completion of a follow-up visit with an osteoporosis care provider and identification of barriers for patients who did not complete this visit. Secondary outcomes included whether or not patients obtained bone health labs, dual-energy x-ray absorptiometry (DEXA) scans, and/or underwent medical treatment for osteoporosis. Results One hundred seventy-five patients met final inclusion criteria and were contacted after discharge. Fifty patients agreed to follow-up with the OC, voicemails were left for 66 patients, only 70 (60.3%) patients actually followed up for bone health analysis. Patients were lost to follow-up due to lack of accessibility (32 patients; death, incorrect phone number, no voicemail, or impaired cognition), and lack of interest (27 patients). Ninety-six (54.9%) patients received appropriate treatment based on bone health labs and/or DEXA scan. Ninety (51.4%) patients had chemical treatment for osteoporosis. Fifty-five patients underwent DEXA scans with equal distribution of patients with normal, osteopenic, and osteoporotic bone. Forty-three (78%) patients who had DEXA scans underwent treatment. Conclusions Establishing a protocol for follow-up for bone health assessment following a DR fracture is challenging. Only half of the patients underwent evaluation and management of their bone health. It is imperative to understand the barriers for at-risk patients to provide them with care that will improve their quality of life. Type of study/level of evidence Diagnostic III.
Published: 2021
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33. Ösophagotracheobronchiale Fisteln

Author: Christiane Bruns, S Brunner, and Wolfgang Schröder
Subjects: Larynx, medicine.medical_specialty, business.industry, Fistula, medicine.medical_treatment, Esophageal cancer, medicine.disease, Intensive care unit, law.invention, Surgery, Sepsis, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Esophageal stent, law, Esophagectomy, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, Esophagus, business
Abstract: Esophagobronchial and esophagotracheal fistulas are rare but complex diseases with a heterogeneous spectrum of underlying etiologies. Common causes are locally advanced tumors of the esophagus and larynx, traumatic perforation from the esophageal or tracheal side as well as postoperative fistulas. The management of esophagotracheal and esophagobronchial fistulas always involves different health care providers and in most cases patients require a multidisciplinary treatment on the intensive care unit. The therapeutic concept primarily depends on the underlying cause, localization and size of the fistula but decision making is also influenced by the severity of the course of sepsis and the extent of the respiratory dysfunction. Endoscopic management with esophageal and/or tracheobronchial stenting is the most common treatment. Surgical reconstructive procedures are predominantly reserved for patients with a treatment refractory fistula or a septic multiple organ failure. The prognosis is particularly influenced by the underlying disease.
Published: 2021
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34. c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1

Author: Jingwei Shi, Nadine Huber, Xiaodong Tian, Uwe Knippschild, Benno Traub, Doris Henne-Bruns, Marko Kornmann, Stefan Schreiner, S. Zhou, and Guowei Chen
Subjects: Cancer Research, Cell growth, Kinase, c-jun, Pancreatic cancer, Biology, medicine.disease, Article, Pancreatic Neoplasms, Small hairpin RNA, Mice, Cell culture, Cancer research, medicine, Animals, Humans, Mitogen-Activated Protein Kinase 9, Molecular Medicine, Immunohistochemistry, Mitogen-Activated Protein Kinase 8, Phosphorylation, Cytoskeleton, Cancer genetics, Molecular Biology
Abstract: The c-Jun N-terminal protein kinases (JNKs) JNK1 and JNK2 can act as either tumor suppressors or pro-oncogenic kinases in human cancers. The isoform-specific roles for JNK1 and JNK2 in human pancreatic cancer are still unclear, the question which should be addressed in this project. Human pancreatic cancer cell lines MIA PaCa-2 and PANC-1 clones were established either expressing either JNK1 or -2 shRNA in a stable manner. Basal anchorage-dependent and –independent cell growth, single-cell movement, and invasion using the Boyden chamber assay were analyzed. Xenograft growth was assessed using an orthotopic mouse model. All seven tested pancreatic cancer cell lines expressed JNKs as did human pancreatic cancer samples determined by immunohistochemistry. Pharmacological, unspecific JNK inhibition (SP600125) reduced cell growth of all cell lines but PANC-1. Especially inhibition of JNK2 resulted in overall increased oncogenic potential with increased proliferation and invasion, associated with alterations in cytoskeleton structure. Specific inhibition of JNK1 revealed opposing functions. Overall, JNK1 and JNK2 can exert different functions in human pancreatic cancer and act as counter players for tumor invasion. Specifically modulating the activity of JNKs may be of potential therapeutic interest in the future.
Published: 2021
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35. Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Author: Haoting Sun, Junjie Pan, Wenwei Zhu, Lu Lu, Qiongzhu Dong, Chao Gao, Hao Wang, Livnat Barsky, Hu-Liang Jia, Razi Vago, Yan Zheng, Lun-Xiu Qin, Christiane Bruns, Jule Caroline Jacob, Yue Zhao, and Shun Wang
Subjects: 0301 basic medicine, Tumour metastasis, Future studies, Vascular alteration, Cellular pathways, Pre-metastatic niche, lcsh:R, lcsh:Medicine, Review, Biology, Extracellular vesicles, medicine.disease, Molecular medicine, Metastasis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Therapeutic strategies, medicine, Cancer research, Bone marrow-derived cells, Immunosuppression
Abstract: Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.
Published: 2021

36. Effectiveness of Mindfulness-Based Cognitive Therapy–Child With Youth Who Have a Parent Diagnosed With Bipolar I Disorder

Author: Sian Cotton, Kaitlyn Bruns, Melissa P. DelBello, Jenni E. Farrow, Amanda C. La Guardia, and Michael D. Brubaker
Subjects: 050103 clinical psychology, Bipolar I disorder, business.industry, 05 social sciences, medicine.disease, 030227 psychiatry, 03 medical and health sciences, 0302 clinical medicine, Medicine, 0501 psychology and cognitive sciences, sense organs, business, Mindfulness-based cognitive therapy, Clinical psychology
Abstract: Youth who have parents with bipolar I disorder appear to be most at risk for developing early-onset bipolar symptoms. The current study examined how one group counseling intervention, mindfulness-based cognitive therapy–child, may improve emotional awareness and influence the family environment over a 12-week treatment interval for a group of youth aged 11–16. Improving emotional awareness and the family environment may help slow symptom expression for youth at risk for developing bipolar I disorder. Changes in depressive symptoms for each participant were assessed using a single-case research design method to help better understand the mechanisms of change throughout treatment. While results indicate changes in emotional awareness, the majority were statistically nonsignificant. Notably, participants’ perception of control significantly changed, and participants reported significant positive changes in family environment. Some participants experienced decreases in depression over the course of the intervention.
Published: 2020
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37. Lipid metabolism in cancer progression and therapeutic strategies

Author: Jimeng Yang, Yan Fu, Qiongzhu Dong, Peter J. Nelson, Yue Zhao, Jiahui Li, Lun-Xiu Qin, Xiao-Tian Shen, Chao Wu, Yan Zheng, Christiane Bruns, and Tiantian Zou
Subjects: Tumor microenvironment, Cell signaling, Cholesterol, lcsh:R, Cell, Phospholipid, lcsh:Medicine, Reviews, mechanism, Cancer, Lipid metabolism, Context (language use), Review, Biology, medicine.disease, microenvironment, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, lipid metabolism, medicine, Cancer research, cancer, lipids (amino acids, peptides, and proteins), therapeutic strategy
Abstract: Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signaling molecules, and source material for the biogenesis of cell membranes. The enhanced synthesis, storage, and uptake of lipids contribute to cancer progression. The rewiring of lipid metabolism in cancer has been linked to the activation of oncogenic signaling pathways and cross talk with the tumor microenvironment. The resulting activity favors the survival and proliferation of tumor cells in the harsh conditions within the tumor. Lipid metabolism also plays a vital role in tumor immunogenicity via effects on the function of the noncancer cells within the tumor microenvironment, especially immune‐associated cells. Targeting altered lipid metabolism pathways has shown potential as a promising anticancer therapy. Here, we review recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression, and discuss the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer. This review sheds new light to fully understanding of the role of lipid metabolic reprogramming in the context of cancer and provides valuable clues on therapeutic strategies targeting lipid metabolism in cancer., Lipid metabolic reprogramming‐mediated crosstalk between cancer cells and tumor microenvironment contributes to cancer progression. Stromal cells, such as adipocyte, CAF, epithelia cells contribute to lipid metabolic reprogramming in cancer cells. Cancer cells undergo lipid metabolism rewiring to generate building materials for membrane, lipid second messenger and energy supply. Cancer cells can also secret lipid metabolites to affect immune cell functions, creating a tumor‐favoring immune microenvironment.
Published: 2020
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38. Does oncological outcome differ between restorative and nonrestorative low anterior resection in patients with primary rectal cancer?

Author: Roodbeen, Sapho X., Blok, Robin D., Borstlap, Wernard A., Bemelman, Willem A., Hompes, Roel, Tanis, Pieter J., Aalbers, A. G. J., Acherman, Y., Algie, G. D., Alting von Geusau, B., Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., Clermonts, S., Coene, P. P. L. O., Compaan, C., Consten, E. C. J., Darbyshire, T., de Mik, S. M. L., van Duijvendijk, P., Gooszen, J. A. H., Hoogland, P., Lamme, B., Marres, C. C., Musters, G. D., van Rossem, C. C., Schreuder, A. M., Swank, H. A., Tuynman, J. B., van Beek, S. C., van Westreenen, H. L., Westerduin, E., Robotics and image-guided minimally-invasive surgery (ROBOTICS), Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Center of Experimental and Molecular Medicine, Surgery, 02 Surgical specialisms, Tytgat Institute for Liver and Intestinal Research, APH - Personalized Medicine, and APH - Quality of Care
Subjects: medicine.medical_specialty, SURGERY, Colorectal cancer, MULTICENTER, Urology, Anastomosis, MESORECTAL EXCISION, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, rectal surgery, Medicine, In patient, Survival analysis, Low Anterior Resection, Neoplasia, oncological outcome, business.industry, Proportional hazards model, Gastroenterology, Original Articles, low anterior resection, medicine.disease, Dissection, 030220 oncology & carcinogenesis, Original Article, 030211 gastroenterology & hepatology, local recurrence, Outcome data, business, RADIOTHERAPY
Abstract: Contains fulltext : 239366.pdf (Publisher’s version ) (Open Access) AIM: Nonrestorative low anterior resection (n-rLAR) (also known as low Hartmann's) is performed for rectal cancer when a poor functional outcome is anticipated or there have been problems when constructing the anastomosis. Compared with restorative LAR (rLAR), little oncological outcome data are available for n-rLAR. The aim of this study was to compare oncological outcomes between rLAR and n-rLAR for primary rectal cancer. METHOD: This was a nationwide cross-sectional comparative study including all elective sphincter-saving LAR procedures for nonmetastatic primary rectal cancer performed in 2011 in 71 Dutch hospitals. Oncological outcomes of patients undergoing rLAR and n-rLAR were collected in 2015; the data were evaluated using Kaplan-Meier survival analysis and the results compared using log-rank testing. Uni- and multivariable Cox regression analysis was used to evaluate the association between the type of LAR and oncological outcome measures. RESULTS: A total of 1197 patients were analysed, of whom 892 (75%) underwent rLAR and 305 (25%) underwent n-rLAR. The 3-year local recurrence (LR) rate was 3% after rLAR and 8% after n-rLAR (P
Published: 2020
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39. Performance of a local reference curve for predicting small for gestational age fetuses in pregnant women with <scp>HIV</scp> / <scp>AIDS</scp>

Author: Natália Roberta Andrade Dalla Costa, Edward Araujo Júnior, Rafael Frederico Bruns, Liziane Lorusso, Letícia Pletsch, Daniel Massamatsu Pianovski Kato, and Elisa Chicareli Pinhat
Subjects: Adult, medicine.medical_specialty, Population, HIV Infections, Reference range, 030204 cardiovascular system & hematology, Ultrasonography, Prenatal, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Fetus, 0302 clinical medicine, Pregnancy, Reference Values, medicine, Humans, Radiology, Nuclear Medicine and imaging, Pregnancy Complications, Infectious, education, reproductive and urinary physiology, Retrospective Studies, education.field_of_study, Small for gestational age fetus, Fetal Growth Retardation, Receiver operating characteristic, Obstetrics, business.industry, Infant, Newborn, Area under the curve, Gold standard (test), medicine.disease, Cross-Sectional Studies, Fetal Weight, ROC Curve, Area Under Curve, Infant, Small for Gestational Age, Small for gestational age, Female, business, Kappa
Abstract: PURPOSE To compare the performance of a local estimated fetal weight curve with curves established for other populations to predict small for gestational age (SGA) fetuses. METHODS A retrospective and cross-sectional study involving 231 fetuses in which the performance of a local curve (proposed model) was compared with the Hadlock and Intergrowth-21st curves in the prediction of SGA fetuses, by applying them to a population of high-risk pregnant woman with HIV/AIDS. For each model, a receiver operating characteristic curve was adjusted, considering the SGA classification by the neonatal Intergrowth method as the gold standard, and the area under the curve (AUC) was calculated. RESULTS The models presented linear correlations with each other. The agreement of the proposed model with Hadlock was very good (kappa = 0.83), whereas the proposed model and Intergrowth-21st had moderate agreement (kappa = 0.44). The SGA fetus detection sensitivities of the proposed model and Hadlock were 61.9% and 57.1%, with specificity of 84.1% and 86.2% and accuracy of 80.1% and 81%, respectively, without statistical difference. The sensitivity of the Intergrowth-21st model was 33.3%, while the accuracy was 85.7% and the specificity was 97.4%. The AUC estimated values for the Hadlock, proposed, and Intergrowth-21st models were 0.834, 0.832, and 0.835, respectively. CONCLUSION The proposed model and Hadlock were interchangeable in the prediction of SGA fetuses and superior to the Intergrowth-21st model.
Published: 2020
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40. Epilepsy Risk Prediction Model for Patients With Tuberous Sclerosis Complex

Author: Laura S. Farach, Melissa A. Richard, Philip J. Lupo, Mustafa Sahin, Darcy A. Krueger, Joyce Y. Wu, Elizabeth M. Bebin, Kit Sing Au, Hope Northrup, M. Sahin, D. Krueger, M. Bebin, J.Y. Wu, H. Northrup, S. Warfield, J. Peters, B. Scherrer, M. Goyal, R. Filip-Dhima, K. Dies, S. Bruns, E. Hanson, N. Bing, B. Kent, S. O'Kelley, M.E. Williams, D. Pearson, G. Cutter, S. Roberds, and D.S. Murray
Subjects: Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Logistic regression, Risk Assessment, Tuberous Sclerosis Complex 1 Protein, Young Adult, 03 medical and health sciences, Tuberous sclerosis, Epilepsy, 0302 clinical medicine, Developmental Neuroscience, Predictive Value of Tests, Risk Factors, Tuberous Sclerosis, 030225 pediatrics, Tuberous Sclerosis Complex 2 Protein, Odds Ratio, Humans, Medicine, Child, Retrospective Studies, business.industry, fungi, food and beverages, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Logistic Models, ROC Curve, Neurology, Child, Preschool, Pediatrics, Perinatology and Child Health, Autism, Female, Neurology (clinical), TSC2, business, Risk assessment, 030217 neurology & neurosurgery
Abstract: Background Individuals with tuberous sclerosis complex are at increased risk of epilepsy. Early seizure control improves developmental outcomes, making identifying at-risk patients critically important. Despite several identified risk factors, it remains difficult to predict. The purpose of the study was to evaluate the combined risk prediction of previously identified risk factors for epilepsy in individuals with tuberous sclerosis complex. Methods The study group (n = 333) consisted of individuals with tuberous sclerosis complex who were enrolled in the Tuberous Sclerosis Complex Autism Center of Excellence Research Network and UT TSC Biobank. The outcome was defined as having an epilepsy diagnosis. Potential risk factors included sex, TSC genotype, and tuber presence. Logistic regression was used to calculate the odds ratio and P value for the association between each variable and epilepsy. A clinical risk prediction model incorporating all risk factors was built. Area under the curve was calculated to characterize the full model's ability to discriminate individuals with tuberous sclerosis complex with and without epilepsy. Results The strongest risk for epilepsy was presence of tubers (95% confidence interval: 2.39 to 10.89). Individuals with pathogenic TSC2 variants were three times more likely (95% confidence interval: 1.55 to 6.36) to develop seizures compared with those with tuberous sclerosis complex from other causes. The combination of risk factors resulted in an area under the curve 0.73. Conclusions Simple characteristics of patients with tuberous sclerosis complex can be combined to successfully predict epilepsy risk. A risk assessment model that incorporates sex, TSC genotype, protective TSC2 missense variant, and tuber presence correctly predicts epilepsy in 73% of patients with tuberous sclerosis complex.
Published: 2020
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41. A Comparison of Prognostic Scores (Mayo, UK-PBC, and GLOBE) in Primary Biliary Cholangitis

Author: Gideon M. Hirschfield, Carla F. Murillo Perez, Frederik Nevens, Jorn C Goet, Keith D Lindor, Albert Parés, Nora Cazzagon, Nikolaos K. Gatselis, Annarosa Floreani, Anna Reig, Willem J Lammers, Florian Prechter, George N. Dalekos, Marco Carbone, Bettina E. Hansen, Maren H. Harms, Henk R. van Buuren, Tony Bruns, Adriaan J. van der Meer, Aliya Gulamhusein, Xavier Verhelst, Gastroenterology & Hepatology, Goet, J, Murillo Perez, C, Harms, M, Floreani, A, Cazzagon, N, Bruns, T, Prechter, F, Dalekos, G, Verhelst, X, Gatselis, N, Lindor, K, Lammers, W, Gulamhusein, A, Reig, A, Carbone, M, Nevens, F, Hirschfield, G, van der Meer, A, van Buuren, H, Hansen, B, and Pares, A
Subjects: Adult, Male, medicine.medical_specialty, Cholagogues and Choleretics, Concordance, medicine.medical_treatment, Liver transplantation, Severity of Illness Index, Cohort Studies, End Stage Liver Disease, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Interquartile range, Internal medicine, medicine, Humans, Cholagogues and Choleretic, Aged, Hyperbilirubinemia, Framingham Risk Score, Hepatology, business.industry, Liver Cirrhosis, Biliary, Ursodeoxycholic Acid, Gastroenterology, Middle Aged, medicine.disease, Prognosis, Confidence interval, Advanced fibrosis, Liver Transplantation, 030220 oncology & carcinogenesis, Cohort, 030211 gastroenterology & hepatology, Female, Cohort Studie, business, Human
Abstract: INTRODUCTION: Comparative data on scores that predict outcome in primary biliary cholangitis (PBC) are scarce. We aimed to assess and compare the prognostic value of the Mayo Risk Score (MRS, 1989 and 1994), UK-PBC score, and GLOBE score in a large international cohort of patients with PBC. METHODS: Ursodeoxycholic acid-treated patients from 7 centers participating in the GLOBAL PBC Study Group were included. The discriminatory performance of the scores was assessed with concordance statistics at yearly intervals up to 5 years. Model for End-stage Liver Disease was included for comparison. Prediction accuracy was assessed by comparing predicted survival and actual survival in Kaplan-Meier analyses. RESULTS: A total of 1,100 ursodeoxycholic acid-treated patients with PBC were included, with a mean (SD) age of 53.6 (12.0) years, of whom 1,003 (91%) were female. During a median follow-up of 7.6 (interquartile range 4.1-11.7) years, 42 patients underwent liver transplantation, and 127 patients died. At 1 year, the concordance statistic for Model for End-stage Liver Disease was 0.68 (95% confidence interval [CI] 0.64-0.72), 0.74 (95% CI 0.67-0.80) for the UK-PBC score, 0.76 (95% CI 0.72-0.81) for the MRS (1989 and 1994), and 0.80 (95% CI 0.76-0.84) for the GLOBE score. The GLOBE score showed superior discriminatory performance, but differences were not statistically different. For all scores, discriminatory performance increased in those with bilirubin >0.6 × ULN and advanced fibrosis estimated with Fibrosis-4. The predicted (median) minus observed 5-year transplant-free survival was +0.4% and +2.5% for the MRS (1989) and GLOBE score, respectively. DISCUSSION: All prognostic scores developed for PBC (GLOBE, UK-PBC, and MRS) demonstrated comparable discriminating performance for liver transplantation or death as well as good prediction accuracy.
Published: 2021

42. Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

Author: Vourli, G., Noori, T., Pharris, A., Porter, K., Axelsson, M., Begovac, J., Cazein, F., Costagliola, D., Cowan, S., Croxford, S., Monforte, A. D., Delpech, V., Diaz, A., Girardi, E., Gunsenheimer-Bartmeyer, B., Hernando, V., Leierer, G., Lot, F., Nunez, O., Obel, N., Op de Coul, E., Paraskeva, D., Patrinos, S., Reiss, P., Schmid, D., Sonnerborg, A., Suligoi, B., Supervie, V., van Sighem, A., Zangerle, R., Touloumi, G., Egle, A., Kanatschnig, M., Ollinger, A., Rieger, A., Schmied, B., Wallner, E., Dewasurendra, D., Gisinger, M., Kitchen, M., Plattner, A., Rieser, E., Sarcletti, M., Greil, R., Schachner, M., Skocic, M., Muller, M., Aichwalder, R., Chromy, D., Grabmeier-Pfstershammer, K., Skoll, M., Touzeau, V., Cichon, P., Wolf-Nussmuller, S., Laferl, H., Zoufaly, A., Genger-Hackl, C., Kapper, A., Schneeberger, T., Trattner, E., Schober, G., Atzl, M., Hartmann, B., Puchhammer-Stockl, E., Berg, J., Appoyer, H., Rappold, M., Strickner, S., Schindelwig, K., Ledergerber, B., Fatkenheuer, G., Gerstof, J., Kronborg, G., Pedersen, C., Larsen, C. S., Pedersen, G., Mohey, R., Nielsen, L., Weise, L., Kvinesdal, B., Jensen, J., Abgrall, S., Bernard, L., Billaud, E., Boue, F., Boyer, L., Cabie, A., Caby, F., Canestri, A., Cotte, L., de Truchis, P., Duval, X., Duvivier, C., Enel, P., Fischer, H., Gasnault, J., Gaud, C., Grabar, S., Khuong-Josses, M. A., Launay, O., Marchand, L., Mary-Krause, M., Matheron, S., Melica-Gregoire, G., Melliez, H., Meynard, J. L., Nacher, M., Pavie, J., Piroth, L., Poizot-Martin, I., Pradier, C., Reynes, J., Rouveix, E., Simon, A., Slama, L., Tattevin, P., Tissot-Dupont, H., Biga, J., Kurth, T., Jacquemet, N., Guiguet, M., Leclercq, S., Lievre, L., Marshall, E., Roul, H., Selinger-Leneman, H., Potard, V., Benveniste, O., Breton, G., Lupin, C., Bourzam, E., Girard, P. M., Fonquernie, L., Valin, N., Lefebvre, B., Sebire, M., Pialoux, G., Lebrette, M. G., Tibaut, P., Adda, A., Hamidi, M., Cadranel, J., Lavole, A., Parrot, A., Bouchaud, O., Vignier, N., Mechai, F., Makhlouf, S., Honore, P., Bergmann, J. F., Delcey, V., Lopes, A., Sellier, P., Parrinello, M., Oksenhendler, E., Gerard, L., Molina, J. M., Rozenbaum, W., Denis, B., De Castro, N., Lascoux, C., Yazdanpanah, Y., Lariven, S., Joly, V., Rioux, C., Poupard, M., Taverne, B., Sutton, L., Masse, V., Genet, P., Wifaq, B., Gerbe, J., Grefe, S., Dupont, C., Freire Maresca, A., Reimann, E., Bloch, M., Meier, F., Mortier, E., Zeng, F., Montoya, B., Perronne, C., Mathez, D., Marigot-Outtandy, D., Berthe, H., Greder Belan, A., Terby, A., Godin Collet, C., Marque Juillet, S., Ruquet, M., Roussin-Bretagne, S., Colardelle, P., Granier, F., Laurichesse, J. J., Perronne, V., Akpan, T., Marcou, M., Daneluzzi, V., Veyssier-Belot, C., Masson, H., Welker, Y., Brazille, P., Kahn, J. E., Zucman, D., Majerholc, C., Fourn, E., Bornarel, D., Chambrin, V., Kansau, I., Raho-Moussa, M., Lelievre, J. D., Saidani, M., Chesnel, C., Dumont, C., Vittecoq, D., Derradji, O., Bolliot, C., Goujard, C., Teicher, E., Mole, M., Bourdic, K., Salmon, D., Le Jeunne, C., Guet, P., Pietri, M. P., Pannier Metzger, E., Marcou, V., Loulergue, P., Dupin, N., Morini, J. P., Deleuze, J., Gerhardt, P., Chanal, J., Weiss, L., Lucas, M. L., Jung, C., Ptak, M., Viard, J. P., Ghosn, J., Gazalet, P., Cros, A., Maignan, A., Lortholary, O., Rouzaud, C., Touam, F., Benhadj, K., Consigny, P. H., Bossi, P., Gergely, A., Cessot, G., Durand, F., Beck-Wirth, G., Michel, C., Benomar, M., Rey, D., Partisani, M., Cheneau, C., Batard, M. L., Fischer, P., Leclercq, P., Blanc, M., Morand, P., Epaulard, O., Signori-Schmuck, A., Laurichesse, H., Jacomet, C., Vidal, M., Coban, D., Casanova, S., Fresard, A., Guglielminotti, C., Botelho-Nevers, E., Brunon-Gagneux, A., Ronat, V., Verdon, R., Dargere, S., Haustraete, E., Feret, P., Goubin, P., Chavanet, P., Fillion, A., Croisier, D., Gohier, S., Arvieux, C., Souala, F., Chapplain, J. M., Ratajczak, M., Rohan, J., Faller, J. P., Ruyer, O., Gendrin, V., Toko, L., Chirouze, C., Hustache-Mathieu, L., Faucher, J. F., Proust, A., Magy-Bertrand, N., Gil, H., Meaux-Ruault, N., Sotto, A., Rouanet, I., Mauboussin, J. M., Doncesco, R., Jacques, G., May, T., Rabaud, C., Andre, M., Delestan, M., Bouillon, M. P., Bani-Sadr, F., Rouger, C., Berger, J. L., Nguyen, Y., Marchou, B., Delobel, P., Martin Blondel, G., Cuzin, L., Biezunski, N., Alric, L., Bonnet, D., Guivarch, M., Palacin, A., Payssan, V., Ajana, F., Meybeck, A., Viget, N., Pugliese, P., Roger, P. M., Rosenthal, E., Durant, J., Cua, E., Naqvi, A., Perbost, I., Risso, K., Quinsat, D., Raphael, St., Del Giudice, P., Dides, P. Y., Sambuc, R., Antolini-Bouvenot, M. S., Druart, P., Meddeb, L., Ravaux, I., Menard, A., Tomei, C., Dhiver, C., Moreau, J., Mokhtari, S., Soavi, M. J., Tomas, V., Bregigeon, S., Faucher, O., Obry-Roguet, V., Ritleng, A. S., Petit, N., Bartoli, C., Ruiz, J. M., Blanc, D., Allegre, T., Sordage, M., Riou, J. M., Faudon, C., Slama, B., Zerazhi, H., Boulat, O., Chebrek, S., Beyrne, M., Granet Brunello, P., Pellissier, L., Bonnabel, D., Cohen Valensi, R., Mouchet, B., Mboungou, G., Lafeuillade, A., Hope-Rapp, E., Hittinger, G., Philip, G., Lambry, V., Raf, F., Allavena, C., Hall, N., Reliquet, V., Chidiac, C., Ferry, T., Perpoint, T., Miailhes, P., Boibieux, A., Livrozet, J. M., Makhlouf, D., Brunel, F., Chiarello, P., Hoen, B., Lamaury, I., Fabre, I., Samar, K., Duvallon, E., Clavel, C., Stegmann, S., Walter, V., Adriouch, L., Huber, F., Vanticlke, V., Couppie, P., Abel, S., Pierre-Francois, S., Ricaud, C., Rodet, R., Wartel, G., Sautron, C., Poubeau, P., Borgherini, G., Camuset, G., Arasteh, K., Kowohl Vivantes, S., Schurmann, D., Warncke Charite, M., Rockstroh, J., Wasmuth, J., Hass, S., Jensen, B. O., Feind, C., Esser, S., Schenk-Westkamp, P., Haberl, A., Stephan, C., Plettenberg, A., Kuhlendahl, F., Adam, A., Weitner, L., Schewe, K., Goey, H., Fenske, S., Buhk, T., Stellbrink, H. J., Hofmann, C., Hansen, S., Degen, O., Heuer, M., Stoll, M., Gerschmann, S., Horst, H., Trautmann, S., Gillor, D., Bogner, J., Sonntag, B., Salzberger, B., Fritzsche, C., Adamis, G., Antoniadou, A., Chini, M., Chrysos, G., Gikas, A., Gogos, H. A., Katsarou, O., Lazanas, M., Metallidis, S., Panagopoulos, P., Paparizos, V., Papastamopoulos, V., Paraskevis, D., Psychogiou, M., Sambatakou, H., Sipsas, N. V., Pantazis, N., Papadopoulos, A., Nitsotolis, T., Xylomenos, G., Marangos, M. N., Kouramba, A., Kontos, A., Lioni, A., Tsachouridou, O., Kourkounti, S., Ganitis, A., Barbounakis, E., d'Arminio Monforte, A., Antinori, A., Andreoni, M., Castagna, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Marchetti, G. C., Rezza, G., von Schloesser, F., Viale, P., Ceccherini-Silberstein, F., Cozzi-Lepri, A., Lo Caputo, S., Mussini, C., Puoti, M., Perno, C. F., Bai, F., Balotta, C., Bandera, A., Bonora, S., Borderi, M., Calcagno, A., Capetti, A., Capobianchi, M. R., Cicalini, S., Cingolani, A., Cinque, P., Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, G., Maggiolo, F., Marchetti, G., Monno, L., Nozza, S., Pinnetti, C., Quiros Roldan, E., Rossotti, R., Rusconi, S., Santoro, M. M., Saracino, A., Sarmati, L., Fanti, I., Galli, L., Lorenzini, P., Rodano, A., Macchia, M., Tavelli, A., Carletti, F., Carrara, S., Di Caro, A., Graziano, S., Petroni, F., Prota, G., Trufa, S., Giacometti, A., Costantini, A., Barocci, V., Angarano, G., Milano, E., Suardi, C., Donati, V., Verucchi, G., Castelnuovo, F., Minardi, C., Menzaghi, B., Abeli, C., Cacopardo, B., Celesia, B., Vecchiet, J., Falasca, K., Pan, A., Lorenzotti, S., Sighinolf, L., Segala, D., Blanc, P., Vichi, F., Cassola, G., Viscoli, C., Alessandrini, A., Bobbio, N., Mazzarello, G., Fondaco, L., Bonfanti, P., Molteni, C., Chiodera, A., Milini, P., Nunnari, G., Pellicano, G., Rizzardini, G., Cannizzo, E. S., Moioli, M. 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H., Pijnappel, F. J. J., Smalhout, S. Y., Weijsenfeld, A. M., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Peters, E. J. G., van Agtmael, M. A., Bomers, M., Sigalof, K. C. E., Heitmuller, M., Laan, L. M., Ang, C. W., van Houdt, R., Jonges, M., van Prehn, J., Kuijpers, T. W., Pajkrt, D., Scherpbier, H. J., de Boer, C., van der Plas, A., van den Berge, M., Stegeman, A., Baas, S., Hage de Loof, L., Wintermans, B., Veenemans, J., Pronk, M. J. H., Ammerlaan, H. S. M., de Munnik, E. S., Jansz, A. R., Tjhie, J., Wegdam, M. C. A., Deiman, B., Scharnhorst, V., van Eeden, A., Brokking, W., Elsenburg, L. J. M., Nobel, H., Damen, M., van Kasteren, M. E. E., Berrevoets, M. A. H., Brouwer, A. E., Adams, A., de Kruijf-Van de Wiel, B. A. F. M., Keelan-Pfaf, S., van der Ven, B., Buiting, A. G. M., Murck, J. L., Versteeg, D., de Vries-Sluijs, T. E. M. S., Bax, H. I., van Gorp, E. C. M., Nouwen, J. L., Rijnders, B. J. A., Schurink, C. A. M., Verbon, A., de Jong-Peltenburg, N. C., Bassant, N., van Beek, J. E. A., Vriesde, M., van Zonneveld, L. M., van den Berg-Cameron, H. J., de Groot, J., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E., Branger, J., Douma, R. A., Duijf-Van de Ven, C. J. H. M., Schippers, E. F., van Nieuwkoop, C., van IJperen, J. M., Geilings, J., van der Hut, G., van Burgel, N. D., Leyten, E. M. S., Gelinck, L. B. S., Mollema, F., Davids-Veldhuis, S., Wildenbeest, G. S., Heikens, E., Groeneveld, P. H. P., Bouwhuis, J. W., Lammers, A. J. J., Kraan, S., van Hulzen, A. G. W., Kruiper, M. S. M., van der Bliek, G. L., Bor, P. C. J., Bloembergen, P., Wolfagen, M. J. H. M., Ruijs, G. J. H. M., Kroon, F. P., de Boer, M. G. J., Scheper, H., Jolink, H., Dorama, W., van Holten, N., Claas, E. C. J., Wessels, E., den Hollander, J. G., El Moussaoui, R., Pogany, K., Kastelijns, M., Smit, J. V., Smit, E., Struik-Kalkman, D., Tearno, C., van Niekerk, T., Pontesilli, O., Lowe, S. H., Oude Lashof, A. M. L., Posthouwer, D., Ackens, R. P., Burgers, K., Schippers, J., Weijenberg-Maes, B., van Loo, I. H. M., Havenith, T. R. A., Weijer, S., van Vonderen, M. G. A., Kampschreur, L. M., Faber, S., Steeman-Bouma, R., Weel, J., Kootstra, G. J., Delsing, C. E., van der Burg-Van de Plas, M., Heins, H., Kortmann, W., van Twillert, G., Renckens, R., Ruiter-Pronk, D., van Truijen-Oud, F. A., Cohen Stuart, J. W. T., Jansen, E. R., Hoogewerf, M., Rozemeijer, W., van der Reijden, W. A., Sinnige, J. C., Brinkman, K., van den Berk, G. E. L., Blok, W. L., Frissen, P. H. J., Lettinga, K. D., Schouten, W. E. M., Veenstra, J., Vrouenraets, S. M. E., Brouwer, C. J., Geerders, G. F., Hoeksema, K., Kleene, M. J., Knapen, M., van der Meche, I. B., Mulder-Seeleman, E., Toonen, A. J. M., Wijnands, S., Kwa, D., van Crevel, R., van Aerde, K., Doferhof, A. S. M., Henriet, S. S. V., ter Hofstede, H. J. M., Hoogerwerf, J., Keuter, M., Richel, O., Albers, M., Grintjes-Huisman, K. J. T., de Haan, M., Marneef, M., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Burger, D., Gisolf, E. H., Hassing, R. J., Claassen, M., ter Beest, G., van Bentum, P. H. M., Langebeek, N., Tiemessen, R., Swanink, C. M. A., van Lelyveld, S. F. L., Soetekouw, R., van der Prijt, L. M. M., van der Swaluw, J., Bermon, N., Jansen, R., Herpers, B. L., Veenendaal, D., Verhagen, D. W. M., Lauw, F. N., van Broekhuizen, M. C., van Wijk, M., Bierman, W. F. W., Bakker, M., Kleinnijenhuis, J., Kloeze, E., Middel, A., Scholvinck, E. H., Stienstra, Y., Verhage, A. R., Wouthuyzen-Bakker, K. M., Boonstra, A., de Groot-De Jonge, H., van der Meulen, P. A., de Weerd, D. A., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Hoepelman, A. I. M., Arends, J. E., Barth, R. E., Bruns, A. H. W., Ellerbroek, P. M., Mudrikova, T., Oosterheert, J. J., de Regt, M. J. A., Schadd, E. M., van Zoelen, M. A. 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A., Campins, A. A., Vidal, C., Gil, L., Fanjul, F., Marinescu, C., Ribera, E., Santos, J., Marquez, M., Viciana, I., Palacios, R., Gonzalez, C. M., Viciana, P., Leal, M., Lopez-Cortes, L. F., Espinosa, N., Munoz, J., Zubero, M. Z., Baraia-Etxaburu, J. M., Ibarra, S., Ferrero, O., Lopez de Munain, J., Camara, M. M., Lopez, I., de la Pena, M., Suarez-Garcia, I., Malmierca, E., Olalla, J., del Arco, A., de la Torre, J., Prada, J. L., Caracuel, Z., Lopez-Lirola, A. M., Lozano, A. B., Fernandez, E., Fernandez, J. M., Martinez, O. J., Vera, F. J., Martinez, L., Garcia, J., Alcaraz, B., Jimeno, A., Poveda, E., Pernas, B., Mena, A., Grandal, M., Castro, A., Pedreira, J. D., Galera, C., Albendin, H., Iborra, A., Campillo, M. A., Vidal, A., Amador, C., Pasquau, F., Ena, J., Benito, C., Fenoll, V., Mohamed-Balghata, M. O., Gomez, M. A., Alberto de Zarraga, M., Rivas, M. E., Gorgolas, M., Svedhem-Johansson, V., Flamholc, L., Gisslen, M., Hejdeman, B., Norgren, H., Wendahl, S., European Centre for Disease Prevention and Control (ECDC), Esser, Stefan (Beitragende*r), Schenk-Westkamp, Pia (Herausgeber*in), Vourli G., Noori T., Pharris A., Porter K., Axelsson M., Begovac J., Cazein F., Costagliola D., Cowan S., Croxford S., Monforte A.D., Delpech V., Diaz A., Girardi E., Gunsenheimer-Bartmeyer B., Hernando V., Leierer G., Lot F., Nunez O., Obel N., Op de Coul E., Paraskeva D., Patrinos S., Reiss P., Schmid D., Sonnerborg A., Suligoi B., Supervie V., van Sighem A., Zangerle R., Touloumi G., Egle A., Kanatschnig M., Ollinger A., Rieger A., Schmied B., Wallner E., Dewasurendra D., Gisinger M., Kitchen M., Plattner A., Rieser E., Sarcletti M., Greil R., Schachner M., Skocic M., Muller M., Aichwalder R., Chromy D., Grabmeier-Pfstershammer K., Skoll M., Touzeau V., Cichon P., Wolf-Nussmuller S., Laferl H., Zoufaly A., Genger-Hackl C., Kapper A., Schneeberger T., Trattner E., Schober G., Atzl M., Hartmann B., Puchhammer-Stockl E., Berg J., Appoyer H., Rappold M., Strickner S., Schindelwig K., Ledergerber B., Fatkenheuer G., Gerstof J., Kronborg G., Pedersen C., Larsen C.S., Pedersen G., Mohey R., Nielsen L., Weise L., Kvinesdal B., Jensen J., Abgrall S., Bernard L., Billaud E., Boue F., Boyer L., Cabie A., Caby F., Canestri A., Cotte L., de Truchis P., Duval X., Duvivier C., Enel P., Fischer H., Gasnault J., Gaud C., Grabar S., Khuong-Josses M.A., Launay O., Marchand L., Mary-Krause M., Matheron S., Melica-Gregoire G., Melliez H., Meynard J.L., Nacher M., Pavie J., Piroth L., Poizot-Martin I., Pradier C., Reynes J., Rouveix E., Simon A., Slama L., Tattevin P., Tissot-Dupont H., Biga J., Kurth T., Jacquemet N., Guiguet M., Leclercq S., Lievre L., Marshall E., Roul H., Selinger-Leneman H., Potard V., Benveniste O., Breton G., Lupin C., Bourzam E., Girard P.M., Fonquernie L., Valin N., Lefebvre B., Sebire M., Pialoux G., Lebrette M.G., Tibaut P., Adda A., Hamidi M., Cadranel J., Lavole A., Parrot A., Bouchaud O., Vignier N., Mechai F., Makhlouf S., Honore P., Bergmann J.F., Delcey V., Lopes A., Sellier P., Parrinello M., Oksenhendler E., Gerard L., Molina J.M., Rozenbaum W., Denis B., De Castro N., Lascoux C., Yazdanpanah Y., Lariven S., Joly V., Rioux C., Poupard M., Taverne B., Sutton L., Masse V., Genet P., Wifaq B., Gerbe J., Grefe S., Dupont C., Freire Maresca A., Reimann E., Bloch M., Meier F., Mortier E., Zeng F., Montoya B., Perronne C., Mathez D., Marigot-Outtandy D., Berthe H., Greder Belan A., Terby A., Godin Collet C., Marque Juillet S., Ruquet M., Roussin-Bretagne S., Colardelle P., Granier F., Laurichesse J.J., Perronne V., Akpan T., Marcou M., Daneluzzi V., Veyssier-Belot C., Masson H., Welker Y., Brazille P., Kahn J.E., Zucman D., Majerholc C., Fourn E., Bornarel D., Chambrin V., Kansau I., Raho-Moussa M., Lelievre J.D., Saidani M., Chesnel C., Dumont C., Vittecoq D., Derradji O., Bolliot C., Goujard C., Teicher E., Mole M., Bourdic K., Salmon D., Le Jeunne C., Guet P., Pietri M.P., Pannier Metzger E., Marcou V., Loulergue P., Dupin N., Morini J.P., Deleuze J., Gerhardt P., Chanal J., Weiss L., Lucas M.L., Jung C., Ptak M., Viard J.P., Ghosn J., Gazalet P., Cros A., Maignan A., Lortholary O., Rouzaud C., Touam F., Benhadj K., Consigny P.H., Bossi P., Gergely A., Cessot G., Durand F., Beck-Wirth G., Michel C., Benomar M., Rey D., Partisani M., Cheneau C., Batard M.L., Fischer P., Leclercq P., Blanc M., Morand P., Epaulard O., Signori-Schmuck A., Laurichesse H., Jacomet C., Vidal M., Coban D., Casanova S., Fresard A., Guglielminotti C., Botelho-Nevers E., Brunon-Gagneux A., Ronat V., Verdon R., Dargere S., Haustraete E., Feret P., Goubin P., Chavanet P., Fillion A., Croisier D., Gohier S., Arvieux C., Souala F., Chapplain J.M., Ratajczak M., Rohan J., Faller J.P., Ruyer O., Gendrin V., Toko L., Chirouze C., Hustache-Mathieu L., Faucher J.F., Proust A., Magy-Bertrand N., Gil H., Meaux-Ruault N., Sotto A., Rouanet I., Mauboussin J.M., Doncesco R., Jacques G., May T., Rabaud C., Andre M., Delestan M., Bouillon M.P., Bani-Sadr F., Rouger C., Berger J.L., Nguyen Y., Marchou B., Delobel P., Martin Blondel G., Cuzin L., Biezunski N., Alric L., Bonnet D., Guivarch M., Palacin A., Payssan V., Ajana F., Meybeck A., Viget N., Pugliese P., Roger P.M., Rosenthal E., Durant J., Cua E., Naqvi A., Perbost I., Risso K., Quinsat D., Raphael St., Del Giudice P., Dides P.Y., Sambuc R., Antolini-Bouvenot M.S., Druart P., Meddeb L., Ravaux I., Menard A., Tomei C., Dhiver C., Moreau J., Mokhtari S., Soavi M.J., Tomas V., Bregigeon S., Faucher O., Obry-Roguet V., Ritleng A.S., Petit N., Bartoli C., Ruiz J.M., Blanc D., Allegre T., Sordage M., Riou J.M., Faudon C., Slama B., Zerazhi H., Boulat O., Chebrek S., Beyrne M., Granet Brunello P., Pellissier L., Bonnabel D., Cohen Valensi R., Mouchet B., Mboungou G., Lafeuillade A., Hope-Rapp E., Hittinger G., Philip G., Lambry V., Raf F., Allavena C., Hall N., Reliquet V., Chidiac C., Ferry T., Perpoint T., Miailhes P., Boibieux A., Livrozet J.M., Makhlouf D., Brunel F., Chiarello P., Hoen B., Lamaury I., Fabre I., Samar K., Duvallon E., Clavel C., Stegmann S., Walter V., Adriouch L., Huber F., Vanticlke V., Couppie P., Abel S., Pierre-Francois S., Ricaud C., Rodet R., Wartel G., Sautron C., Poubeau P., Borgherini G., Camuset G., Arasteh K., Kowohl Vivantes S., Schurmann D., Warncke Charite M., Rockstroh J., Wasmuth J., Hass S., Jensen B.O., Feind C., Esser S., Schenk-Westkamp P., Haberl A., Stephan C., Plettenberg A., Kuhlendahl F., Adam A., Weitner L., Schewe K., Goey H., Fenske S., Buhk T., Stellbrink H.J., Hofmann C., Hansen S., Degen O., Heuer M., Stoll M., Gerschmann S., Horst H., Trautmann S., Gillor D., Bogner J., Sonntag B., Salzberger B., Fritzsche C., Adamis G., Antoniadou A., Chini M., Chrysos G., Gikas A., Gogos H.A., Katsarou O., Lazanas M., Metallidis S., Panagopoulos P., Paparizos V., Papastamopoulos V., Paraskevis D., Psychogiou M., Sambatakou H., Sipsas N.V., Pantazis N., Papadopoulos A., Nitsotolis T., Xylomenos G., Marangos M.N., Kouramba A., Kontos A., Lioni A., Tsachouridou O., Kourkounti S., Ganitis A., Barbounakis E., d'Arminio Monforte A., Antinori A., Andreoni M., Castagna A., Castelli F., Cauda R., Di Perri G., Galli M., Iardino R., Ippolito G., Lazzarin A., Marchetti G.C., Rezza G., von Schloesser F., Viale P., Ceccherini-Silberstein F., Cozzi-Lepri A., Lo Caputo S., Mussini C., Puoti M., Perno C.F., Bai F., Balotta C., Bandera A., Bonora S., Borderi M., Calcagno A., Capetti A., Capobianchi M.R., Cicalini S., Cingolani A., Cinque P., Di Biagio A., Gianotti N., Gori A., Guaraldi G., Lapadula G., Lichtner M., Madeddu G., Maggiolo F., Marchetti G., Monno L., Nozza S., Pinnetti C., Quiros Roldan E., Rossotti R., Rusconi S., Santoro M.M., Saracino A., Sarmati L., Fanti I., Galli L., Lorenzini P., Rodano A., Macchia M., Tavelli A., Carletti F., Carrara S., Di Caro A., Graziano S., Petroni F., Prota G., Trufa S., Giacometti A., Costantini A., Barocci V., Angarano G., Milano E., Suardi C., Donati V., Verucchi G., Castelnuovo F., Minardi C., Menzaghi B., Abeli C., Cacopardo B., Celesia B., Vecchiet J., Falasca K., Pan A., Lorenzotti S., Sighinolf L., Segala D., Blanc P., Vichi F., Cassola G., Viscoli C., Alessandrini A., Bobbio N., Mazzarello G., Fondaco L., Bonfanti P., Molteni C., Chiodera A., Milini P., Nunnari G., Pellicano G., Rizzardini G., Cannizzo E.S., Moioli M.C., Piolini R., Bernacchia D., Salpietro S., Tincati C., Puzzolante C., Migliorino C., Sangiovanni V., Borgia G., Esposito V., Di Flumeri G., Gentile I., Rizzo V., Cattelan A.M., Marinello S., Cascio A., Trizzino M., Francisci D., Schiaroli E., Parruti G., Sozio F., Magnani G., Ursitti M.A., Cristaudo A., Vullo V., Acinapura R., Moschese D., Capozzi M., Mondi A., Rivano Capparuccia M., Iaiani G., Latini A., Gagliardini R., Plazzi M.M., De Girolamo G., Vergori A., Cecchetto M., Viviani F., De Vito A., Rossetti B., Montagnani F., Franco A., Fontana Del Vecchio R., Di Giuli C., Caramello P., Orofno G.C., Sciandra M., Bassetti M., Londero A., Manfrin V., Battagin G., Starnini G., Ialungo A., van der Valk M., Geerlings S.E., Goorhuis A., Hovius J.W., Lempkes B., Nellen F.J.B., van der Poll T., Prins J.M., van Vugt M., Wiersinga W.J., Wit F.W.M.N., van Duinen M., van Eden J., Hazenberg A., van Hes A.M.H., Pijnappel F.J.J., Smalhout S.Y., Weijsenfeld A.M., Jurriaans S., Back N.K.T., Zaaijer H.L., Berkhout B., Cornelissen M.T.E., Schinkel C.J., Wolthers K.C., Peters E.J.G., van Agtmael M.A., Bomers M., Sigalof K.C.E., Heitmuller M., Laan L.M., Ang C.W., van Houdt R., Jonges M., van Prehn J., Kuijpers T.W., Pajkrt D., Scherpbier H.J., de Boer C., van der Plas A., van den Berge M., Stegeman A., Baas S., Hage de Loof L., Wintermans B., Veenemans J., Pronk M.J.H., Ammerlaan H.S.M., de Munnik E.S., Jansz A.R., Tjhie J., Wegdam M.C.A., Deiman B., Scharnhorst V., van Eeden A., Brokking W., Elsenburg L.J.M., Nobel H., Damen M., van Kasteren M.E.E., Berrevoets M.A.H., Brouwer A.E., Adams A., de Kruijf-Van de Wiel B.A.F.M., Keelan-Pfaf S., van der Ven B., Buiting A.G.M., Murck J.L., Versteeg D., de Vries-Sluijs T.E.M.S., Bax H.I., van Gorp E.C.M., Nouwen J.L., Rijnders B.J.A., Schurink C.A.M., Verbon A., de Jong-Peltenburg N.C., Bassant N., van Beek J.E.A., Vriesde M., van Zonneveld L.M., van den Berg-Cameron H.J., de Groot J., Boucher C.A.B., Koopmans M.P.G., van Kampen J.J.A., Fraaij P.L.A., van Rossum A.M.C., Vermont C.L., van der Knaap L.C., Visser E., Branger J., Douma R.A., Duijf-Van de Ven C.J.H.M., Schippers E.F., van Nieuwkoop C., van IJperen J.M., Geilings J., van der Hut G., van Burgel N.D., Leyten E.M.S., Gelinck L.B.S., Mollema F., Davids-Veldhuis S., Wildenbeest G.S., Heikens E., Groeneveld P.H.P., Bouwhuis J.W., Lammers A.J.J., Kraan S., van Hulzen A.G.W., Kruiper M.S.M., van der Bliek G.L., Bor P.C.J., Bloembergen P., Wolfagen M.J.H.M., Ruijs G.J.H.M., Kroon F.P., de Boer M.G.J., Scheper H., Jolink H., Dorama W., van Holten N., Claas E.C.J., Wessels E., den Hollander J.G., El Moussaoui R., Pogany K., Kastelijns M., Smit J.V., Smit E., Struik-Kalkman D., Tearno C., van Niekerk T., Pontesilli O., Lowe S.H., Oude Lashof A.M.L., Posthouwer D., Ackens R.P., Burgers K., Schippers J., Weijenberg-Maes B., van Loo I.H.M., Havenith T.R.A., Weijer S., van Vonderen M.G.A., Kampschreur L.M., Faber S., Steeman-Bouma R., Weel J., Kootstra G.J., Delsing C.E., van der Burg-Van de Plas M., Heins H., Kortmann W., van Twillert G., Renckens R., Ruiter-Pronk D., van Truijen-Oud F.A., Cohen Stuart J.W.T., Jansen E.R., Hoogewerf M., Rozemeijer W., van der Reijden W.A., Sinnige J.C., Brinkman K., van den Berk G.E.L., Blok W.L., Frissen P.H.J., Lettinga K.D., Schouten W.E.M., Veenstra J., Vrouenraets S.M.E., Brouwer C.J., Geerders G.F., Hoeksema K., Kleene M.J., Knapen M., van der Meche I.B., Mulder-Seeleman E., Toonen A.J.M., Wijnands S., Kwa D., van Crevel R., van Aerde 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Pedreira J.D., Galera C., Albendin H., Iborra A., Campillo M.A., Vidal A., Amador C., Pasquau F., Ena J., Benito C., Fenoll V., Mohamed-Balghata M.O., Gomez M.A., Alberto de Zarraga M., Rivas M.E., Gorgolas M., Svedhem-Johansson V., Flamholc L., Gisslen M., Hejdeman B., Norgren H., Wendahl S., Global Health, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, ANS - Neuroinfection & -inflammation, Internal medicine, Medical Microbiology and Infection Prevention, AMS - Rehabilitation & Development, VU University medical center, Amsterdam Gastroenterology Endocrinology Metabolism, Pediatric surgery, Neurology, Amsterdam Neuroscience - Neurodegeneration, Pulmonary medicine, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Ethics, Law & Medical humanities, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Reproduction & Development (AR&D), APH - Societal Participation & Health, Pediatrics, HAL-SU, Gestionnaire, National and Kapodistrian University of Athens (NKUA), University College of London [London] (UCL), Public Health Agency of Sweden, University of Zagreb, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Statens Serum Institut [Copenhagen], Public Health England [London], Università degli Studi di Milano = University of Milan (UNIMI), Instituto de Salud Carlos III [Madrid] (ISC), Istituto Nazionale di Malattie Infettive 'Lazzaro Spallanzani' (INMI), Robert Koch Institute [Berlin] (RKI), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), University of Copenhagen = Københavns Universitet (UCPH), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Hellenic Center for Disease Control and Prevention, Amsterdam UMC - Amsterdam University Medical Center, Austrian Agency for Health and Food Safety (AGES), Department of Infectious Diseases, Institution of Medicine, Karolinska University Hospital and Karolinska Institutet, Istituto Superiore di Sanita [Rome], Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), University of Athens Medical School [Athens], Vourli, G, Noori, T, Pharris, A, Porter, K, Axelsson, M, Begovac, J, Cazein, F, Costagliola, D, Cowan, S, Croxford, S, Monforte, A, Delpech, V, Diaz, A, Girardi, E, Gunsenheimer-Bartmeyer, B, Hernando, V, Leierer, G, Lot, F, Nunez, O, Obel, N, Op de Coul, E, Paraskeva, D, Patrinos, S, Reiss, P, Schmid, D, Sonnerborg, A, Suligoi, B, Supervie, V, van Sighem, A, Zangerle, R, Touloumi, G, Egle, A, Kanatschnig, M, Ollinger, A, Rieger, A, Schmied, B, Wallner, E, Dewasurendra, D, Gisinger, M, Kitchen, M, Plattner, A, Rieser, E, Sarcletti, M, Greil, R, Schachner, M, Skocic, M, Muller, M, Aichwalder, R, Chromy, D, Grabmeier-Pfstershammer, K, Skoll, M, Touzeau, V, Cichon, P, Wolf-Nussmuller, S, Laferl, H, Zoufaly, A, Genger-Hackl, C, Kapper, A, Schneeberger, T, Trattner, E, Schober, G, Atzl, M, Hartmann, B, Puchhammer-Stockl, E, Berg, J, Appoyer, H, Rappold, M, Strickner, S, Schindelwig, K, Ledergerber, B, Fatkenheuer, G, Gerstof, J, Kronborg, G, Pedersen, C, Larsen, C, Pedersen, G, Mohey, R, Nielsen, L, Weise, L, Kvinesdal, B, Jensen, J, Abgrall, S, Bernard, L, Billaud, E, Boue, F, Boyer, L, Cabie, A, Caby, F, Canestri, A, Cotte, L, de Truchis, P, Duval, X, Duvivier, C, Enel, P, Fischer, H, Gasnault, J, Gaud, C, Grabar, S, Khuong-Josses, M, Launay, O, Marchand, L, Mary-Krause, M, Matheron, S, Melica-Gregoire, G, Melliez, H, Meynard, J, Nacher, M, Pavie, J, Piroth, L, Poizot-Martin, I, Pradier, C, Reynes, J, Rouveix, E, Simon, A, Slama, L, Tattevin, P, Tissot-Dupont, H, Biga, J, Kurth, T, Jacquemet, N, Guiguet, M, Leclercq, S, Lievre, L, Marshall, E, Roul, H, Selinger-Leneman, H, Potard, V, Benveniste, O, Breton, G, Lupin, C, Bourzam, E, Girard, P, Fonquernie, L, Valin, N, Lefebvre, B, Sebire, M, Pialoux, G, Lebrette, M, Tibaut, P, Adda, A, Hamidi, M, Cadranel, J, Lavole, A, Parrot, A, Bouchaud, O, Vignier, N, Mechai, F, Makhlouf, S, Honore, P, Bergmann, J, Delcey, V, Lopes, A, Sellier, P, Parrinello, M, Oksenhendler, E, Gerard, L, Molina, J, Rozenbaum, W, Denis, B, De Castro, N, Lascoux, C, Yazdanpanah, Y, Lariven, S, Joly, V, Rioux, C, Poupard, M, Taverne, B, Sutton, L, Masse, V, Genet, P, Wifaq, B, Gerbe, J, Grefe, S, Dupont, C, Freire Maresca, A, Reimann, E, Bloch, M, Meier, F, Mortier, E, Zeng, F, Montoya, B, Perronne, C, Mathez, D, Marigot-Outtandy, D, Berthe, H, Greder Belan, A, Terby, A, Godin Collet, C, Marque Juillet, S, Ruquet, M, Roussin-Bretagne, S, Colardelle, P, Granier, F, Laurichesse, J, Perronne, V, Akpan, T, Marcou, M, Daneluzzi, V, Veyssier-Belot, C, Masson, H, Welker, Y, Brazille, P, Kahn, J, Zucman, D, Majerholc, C, Fourn, E, Bornarel, D, Chambrin, V, Kansau, I, Raho-Moussa, M, Lelievre, J, Saidani, M, Chesnel, C, Dumont, C, Vittecoq, D, Derradji, O, Bolliot, C, Goujard, C, Teicher, E, Mole, M, Bourdic, K, Salmon, D, Le Jeunne, C, Guet, P, Pietri, M, Pannier Metzger, E, Marcou, V, Loulergue, P, Dupin, N, Morini, J, Deleuze, J, Gerhardt, P, Chanal, J, Weiss, L, Lucas, M, Jung, C, Ptak, M, Viard, J, Ghosn, J, Gazalet, P, Cros, A, Maignan, A, Lortholary, O, Rouzaud, C, Touam, F, Benhadj, K, Consigny, P, Bossi, P, Gergely, A, Cessot, G, Durand, F, Beck-Wirth, G, Michel, C, Benomar, M, Rey, D, Partisani, M, Cheneau, C, Batard, M, Fischer, P, Leclercq, P, Blanc, M, Morand, P, Epaulard, O, Signori-Schmuck, A, Laurichesse, H, Jacomet, C, Vidal, M, Coban, D, Casanova, S, Fresard, A, Guglielminotti, C, Botelho-Nevers, E, Brunon-Gagneux, A, Ronat, V, Verdon, R, Dargere, S, Haustraete, E, Feret, P, Goubin, P, Chavanet, P, Fillion, A, Croisier, D, Gohier, S, Arvieux, C, Souala, F, Chapplain, J, Ratajczak, M, Rohan, J, Faller, J, Ruyer, O, Gendrin, V, Toko, L, Chirouze, C, Hustache-Mathieu, L, Faucher, J, Proust, A, Magy-Bertrand, N, Gil, H, Meaux-Ruault, N, Sotto, A, Rouanet, I, Mauboussin, J, Doncesco, R, Jacques, G, May, T, Rabaud, C, Andre, M, Delestan, M, Bouillon, M, Bani-Sadr, F, Rouger, C, Berger, J, Nguyen, Y, Marchou, B, Delobel, P, Martin Blondel, G, Cuzin, L, Biezunski, N, Alric, L, Bonnet, D, Guivarch, M, Palacin, A, Payssan, V, Ajana, F, Meybeck, A, Viget, N, Pugliese, P, Roger, P, Rosenthal, E, Durant, J, Cua, E, Naqvi, A, Perbost, I, Risso, K, Quinsat, D, Raphael, S, Del Giudice, P, Dides, P, Sambuc, R, Antolini-Bouvenot, M, Druart, P, Meddeb, L, Ravaux, I, Menard, A, Tomei, C, Dhiver, C, Moreau, J, Mokhtari, S, Soavi, M, Tomas, V, Bregigeon, S, Faucher, O, Obry-Roguet, V, Ritleng, A, Petit, N, Bartoli, C, Ruiz, J, Blanc, D, Allegre, T, Sordage, M, Riou, J, Faudon, C, Slama, B, Zerazhi, H, Boulat, O, Chebrek, S, Beyrne, M, Granet Brunello, P, Pellissier, L, Bonnabel, D, Cohen Valensi, R, Mouchet, B, Mboungou, G, Lafeuillade, A, Hope-Rapp, E, Hittinger, G, Philip, G, Lambry, V, Raf, F, Allavena, C, Hall, N, Reliquet, V, Chidiac, C, Ferry, T, Perpoint, T, Miailhes, P, Boibieux, A, Livrozet, J, Makhlouf, D, Brunel, F, Chiarello, P, Hoen, B, Lamaury, I, Fabre, I, Samar, K, Duvallon, E, Clavel, C, Stegmann, S, Walter, V, Adriouch, L, Huber, F, Vanticlke, V, Couppie, P, Abel, S, Pierre-Francois, S, Ricaud, C, Rodet, R, Wartel, G, Sautron, C, Poubeau, P, Borgherini, G, Camuset, G, Arasteh, K, Kowohl Vivantes, S, Schurmann, D, Warncke Charite, M, Rockstroh, J, Wasmuth, J, Hass, S, Jensen, B, Feind, C, Esser, S, Schenk-Westkamp, P, Haberl, A, Stephan, C, Plettenberg, A, Kuhlendahl, F, Adam, A, Weitner, L, Schewe, K, Goey, H, Fenske, S, Buhk, T, Stellbrink, H, Hofmann, C, Hansen, S, Degen, O, Heuer, M, Stoll, M, Gerschmann, S, Horst, H, Trautmann, S, Gillor, D, Bogner, J, Sonntag, B, Salzberger, B, Fritzsche, C, Adamis, G, Antoniadou, A, Chini, M, Chrysos, G, Gikas, A, Gogos, H, Katsarou, O, Lazanas, M, Metallidis, S, Panagopoulos, P, Paparizos, V, Papastamopoulos, V, Paraskevis, D, Psychogiou, M, Sambatakou, H, Sipsas, N, Pantazis, N, Papadopoulos, A, Nitsotolis, T, Xylomenos, G, Marangos, M, Kouramba, A, Kontos, A, Lioni, A, Tsachouridou, O, Kourkounti, S, Ganitis, A, Barbounakis, E, d'Arminio Monforte, A, Antinori, A, Andreoni, M, Castagna, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Marchetti, G, Rezza, G, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Cozzi-Lepri, A, Lo Caputo, S, Mussini, C, Puoti, M, Perno, C, Bai, F, Balotta, C, Bandera, A, Bonora, S, Borderi, M, Calcagno, A, Capetti, A, Capobianchi, M, Cicalini, S, Cingolani, A, Cinque, P, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Monno, L, Nozza, S, Pinnetti, C, Quiros Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Sarmati, L, Fanti, I, Galli, L, Lorenzini, P, Rodano, A, Macchia, M, Tavelli, A, Carletti, F, Carrara, S, Di Caro, A, Graziano, S, Petroni, F, Prota, G, Trufa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Milano, E, Suardi, C, Donati, V, Verucchi, G, Castelnuovo, F, Minardi, C, Menzaghi, B, Abeli, C, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolf, L, Segala, D, Blanc, P, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Fondaco, L, Bonfanti, P, Molteni, C, Chiodera, A, Milini, P, Nunnari, G, Pellicano, G, Rizzardini, G, Cannizzo, E, Moioli, M, Piolini, R, Bernacchia, D, Salpietro, S, Tincati, C, Puzzolante, C, Migliorino, C, Sangiovanni, V, Borgia, G, Esposito, V, Di Flumeri, G, Gentile, I, Rizzo, V, Cattelan, A, Marinello, S, Cascio, A, Trizzino, M, Francisci, D, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Vullo, V, Acinapura, R, Moschese, D, Capozzi, M, Mondi, A, Rivano Capparuccia, M, Iaiani, G, Latini, A, Gagliardini, R, Plazzi, M, De Girolamo, G, Vergori, A, Cecchetto, M, Viviani, F, De Vito, A, Rossetti, B, Montagnani, F, Franco, A, Fontana Del Vecchio, R, Di Giuli, C, Caramello, P, Orofno, G, Sciandra, M, Bassetti, M, Londero, A, Manfrin, V, Battagin, G, Starnini, G, Ialungo, A, van der Valk, M, Geerlings, S, Goorhuis, A, Hovius, J, Lempkes, B, Nellen, F, van der Poll, T, Prins, J, van Vugt, M, Wiersinga, W, Wit, F, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A, Pijnappel, F, Smalhout, S, Weijsenfeld, A, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Wolthers, K, Peters, E, van Agtmael, M, Bomers, M, Sigalof, K, Heitmuller, M, Laan, L, Ang, C, van Houdt, R, Jonges, M, van Prehn, J, Kuijpers, T, Pajkrt, D, Scherpbier, H, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Loof, L, Wintermans, B, Veenemans, J, Pronk, M, Ammerlaan, H, de Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van Eeden, A, Brokking, W, Elsenburg, L, Nobel, H, Damen, M, van Kasteren, M, Berrevoets, M, Brouwer, A, Adams, A, de Kruijf-Van de Wiel, B, Keelan-Pfaf, S, van der Ven, B, Buiting, A, Murck, J, Versteeg, D, de Vries-Sluijs, T, Bax, H, van Gorp, E, Nouwen, J, Rijnders, B, Schurink, C, Verbon, A, de Jong-Peltenburg, N, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, van den Berg-Cameron, H, de Groot, J, Boucher, C, Koopmans, M, van Kampen, J, Fraaij, P, van Rossum, A, Vermont, C, van der Knaap, L, Visser, E, Branger, J, Douma, R, Duijf-Van de Ven, C, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, van Burgel, N, Leyten, E, Gelinck, L, Mollema, F, Davids-Veldhuis, S, Wildenbeest, G, Heikens, E, Groeneveld, P, Bouwhuis, J, Lammers, A, Kraan, S, van Hulzen, A, Kruiper, M, van der Bliek, G, Bor, P, Bloembergen, P, Wolfagen, M, Ruijs, G, Kroon, F, de Boer, M, Scheper, H, Jolink, H, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, El Moussaoui, R, Pogany, K, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, van Niekerk, T, Pontesilli, O, Lowe, S, Oude Lashof, A, Posthouwer, D, Ackens, R, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I, Havenith, T, Weijer, S, van Vonderen, M, Kampschreur, L, Faber, S, Steeman-Bouma, R, Weel, J, Kootstra, G, Delsing, C, van der Burg-Van de Plas, M, Heins, H, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F, Cohen Stuart, J, Jansen, E, Hoogewerf, M, Rozemeijer, W, van der Reijden, W, Sinnige, J, Brinkman, K, van den Berk, G, Blok, W, Frissen, P, Lettinga, K, Schouten, W, Veenstra, J, Vrouenraets, S, Brouwer, C, Geerders, G, Hoeksema, K, Kleene, M, Knapen, M, van der Meche, I, Mulder-Seeleman, E, Toonen, A, Wijnands, S, Kwa, D, van Crevel, R, van Aerde, K, Doferhof, A, Henriet, S, ter Hofstede, H, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F, Burger, D, Gisolf, E, Hassing, R, Claassen, M, ter Beest, G, van Bentum, P, Langebeek, N, Tiemessen, R, Swanink, C, van Lelyveld, S, Soetekouw, R, van der Prijt, L, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B, Veenendaal, D, Verhagen, D, Lauw, F, van Broekhuizen, M, van Wijk, M, Bierman, W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Scholvinck, E, Stienstra, Y, Verhage, A, Wouthuyzen-Bakker, K, Boonstra, A, de Groot-De Jonge, H, van der Meulen, P, de Weerd, D, Niesters, H, van Leer-Buter, C, Knoester, M, Hoepelman, A, Arends, J, Barth, R, Bruns, A, Ellerbroek, P, Mudrikova, T, Oosterheert, J, de Regt, M, Schadd, E, van Zoelen, M, Aarsman, K, Grifoen-Van Santen, B, de Kroon, I, van Rooijen, C, van Berkel, M, Schuurman, R, Verduyn-Lunel, F, Wensing, A, Bont, L, Geelen, S, Loefen, Y, Wolfs, T, Nauta, N, Zaheri, S, Boyd, A, Bezemer, D, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Bretin, N, Djoechro, E, Geerlinks, J, Kruijne, E, Lodewijk, C, Lucas, E, van der Meer, R, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnorr, P, Tuijn, E, Veenenberg, L, Witte, E, Tuk, B, Moreno, S, del Amo, J, Dalmau, D, Navarro, M, Gonzalez, M, Blanco, J, Garcia, F, Rubio, R, Iribarren, J, Gutierrez, F, Vidal, F, Berenguer, J, Gonzalez, J, Sobrino, P, Alejos, B, Alvarez, D, Jarrin, I, Moreno, C, Munoz-Fernandez, M, Garcia-Merino, I, Rico, C, de la Fuente, J, Torre, A, Portilla, J, Merino, E, Reus, S, Boix, V, Giner, L, Gadea, C, Portilla, I, Pampliega, M, Diez, M, Rodriguez, J, Sanchez-Paya, J, Podzamczer, D, Imaz, E, Van Den Eyncle, E, Di Yacovo, S, Sumoy, M, Gomez, J, Hernandez, J, Aleman, M, Alonso, M, Hernandez, M, Diaz-Flores, F, Garcia, D, Pelazas, R, Asensi, V, Valle, E, Carton, J, Perez, V, Molina, M, Garcia, J, Carrera, E, Pulido, F, Bisbal, O, Matarranz, M, Lagarde, M, Rubio-Martin, R, Hernando, A, Bermejo, L, Dominguez, L, Arrizabalaga, J, Aramburu, M, Camino, X, Rodriguez-Arrondo, F, von Wichmann, M, Tome, L, Goenaga, M, Bustinduy, M, Galparsoro, H, Ibarguren, M, Aguado, M, Umerez, M, Masia, M, Lopez, C, Padilla, S, Navarro, A, Montolio, F, Robledano, C, Colome, J, Adsuar, A, Pascual, R, Carlos, F, Martinez, M, Fernandez, M, Garcia, E, Muga, R, Tor, J, Sanvisens, A, Bernaldo de Quiros Lopez, J, Miralles, P, Gutierrez, I, Ramirez, M, Padilla, B, Gijon, P, Carrero, A, Aldamiz-Echevarria, T, Tejerina, F, Parras, F, Balsalobre, P, Diez, C, Peraire, J, Vilades, C, Veloso, S, Vargas, M, Lopez-Dupla, M, Olona, M, Aguilar, A, Sirvent, J, Alba, V, Calavia, O, Montero, M, Lacruz, J, Blanes, M, Calabuig, E, Cuellar, S, Lopez, J, Salavert, M, de la Serna, I, Arribas, J, Montes, M, Pena, J, Arribas, B, Castro, J, Zamora, J, Perez, I, Estebanez, M, Garcia, S, Diaz, M, Alcariz, N, Mingorance, J, Montero, D, Gonzalez, A, Isabel de Jose, M, de los Santos, I, Sanz, J, Salas, A, Sarria, C, Berrocal, A, Garcia-Fraile, L, Oteo, J, Ibarra, V, Metola, L, Sanz, M, Perez-Martinez, L, Pascual, A, Ramos, C, Arazo, P, Gil, D, Jaen, A, Cairo, M, Irigoyen, D, Jordano, Q, Xercavins, M, Martinez-Lacasa, J, Velli, P, Font, R, Sanmarti, M, Ibanez, L, Rivero, M, Casado, M, Diaz, J, Uriz, J, Reparaz, J, Irigoyen, C, Arraiza, M, Segura, F, Amengual, M, Navarro, G, Sala, M, Cervantes, M, Pineda, V, Segura, V, Anton, E, Nogueras, M, Casado, J, Dronda, F, Moreno, A, Elias, M, Lopez, D, Gutierrez, C, Madrid, N, Lamas, A, Marti, P, de Diaz, A, Serrrano, S, Donat, L, Cano, A, Bernal, E, Munoz, A, Pena, A, Munoz, L, Parra, J, Alvarez, M, Chueca, N, Guillot, V, Vinuesa, D, Fernandez, J, Del Romero, J, Rodriguez, C, Puerta, T, Carrio, J, Vera, M, Ballesteros, J, Domingo, P, Sambeat, M, Lamarca, K, Mateo, G, Gutierrez, M, Fernandez, I, Antela, A, Losada, E, Riera, M, Penaranda, M, Leyes, M, Ribas, M, Campins, A, Vidal, C, Gil, L, Fanjul, F, Marinescu, C, Ribera, E, Santos, J, Marquez, M, Viciana, I, Palacios, R, Gonzalez, C, Viciana, P, Leal, M, Lopez-Cortes, L, Espinosa, N, Munoz, J, Zubero, M, Baraia-Etxaburu, J, Ibarra, S, Ferrero, O, Lopez de Munain, J, Camara, M, Lopez, I, de la Pena, M, Suarez-Garcia, I, Malmierca, E, Olalla, J, del Arco, A, de la Torre, J, Prada, J, Caracuel, Z, Lopez-Lirola, A, Lozano, A, Fernandez, E, Martinez, O, Vera, F, Martinez, L, Alcaraz, B, Jimeno, A, Poveda, E, Pernas, B, Mena, A, Grandal, M, Castro, A, Pedreira, J, Galera, C, Albendin, H, Iborra, A, Campillo, M, Vidal, A, Amador, C, Pasquau, F, Ena, J, Benito, C, Fenoll, V, Mohamed-Balghata, M, Gomez, M, Alberto de Zarraga, M, Rivas, M, Gorgolas, M, Svedhem-Johansson, V, Flamholc, L, Gisslen, M, Hejdeman, B, Norgren, H, and Wendahl, S
Subjects: Male, 0301 basic medicine, Psychological intervention, Human immunodeficiency virus (HIV), Medizin, Continuum of care, Europe, HIV infection, Key population, Sex, Anti-Retroviral Agents, Continuity of Patient Care, European Union, HIV, Humans, HIV Infections, medicine.disease_cause, key population, 0302 clinical medicine, HIV Infection, 030212 general & internal medicine, Men having sex with men, media_common, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Transmission (medicine), Infectious Diseases, AcademicSubjects/MED00290, HIV infection, continuum of care, sex, key population, Europe, Microbiology (medical), Population, Socio-culturale, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), SDG 3 - Good Health and Well-being, medicine, media_common.cataloged_instance, European union, education, Pandemics, continuum of care, sex, business.industry, SARS-CoV-2, COVID-19, medicine.disease, 030112 virology, Major Articles and Commentaries, Anti-Retroviral Agent, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography
Abstract: Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control., Standardized definitions were used to estimate a 4-stage continuum of human immunodeficiency virus (HIV) care in 11 European Union (EU) countries in 2016. The EU is close to the 90-90-90 target, with the main challenge being the percentage of undiagnosed infections.
Published: 2020
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43. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Author: Sylvie Tresson, Sara Mareso, Daniela Campion, Agustín Albillos, Alex Amoros, Hans Van Vlierberghe, Manuel Romero-Gómez, Andrea De Gottardi, Thomas Reiberger, Vicente Arroyo, Boglarka Balogh, Miriam Maschmeier, Marco Pavesi, Javier Martínez, Harald Rupprechter, Sara Montagnese, Alessandra Pohlmann, Minneke J. Coenraad, Pierre Nahon, Agnese Antognoli, Jose Presa Ramos, Christoph Welsch, Alexander L. Gerbes, Pietro Gatti, Richard Moreau, Wim Laleman, Mauro Bernardi, Karen Vagner Danielsen, Laure Elkrief, Christian Jansen, Alexander Zipprich, Lise Lotte Gluud, Paul Horn, Ilaria Giovo, Roland Amathieu, Martina Rizzo, Elisabet Garcia, Joan Clària, Oliviero Riggio, Cristina Sanchez, Rita Garcia, Florian Rainer, Sven Francque, Manuela Merli, Giorgio Maria Saracco, Javier J.M. Fernández, Mária Papp, Martina Gagliardi, Antonella Putignano, Claire Francoz, Debbie L. Shawcross, Manuel Tufoni, Ferran Aguilar, Paola Ponzo, Heinz Zoller, Elsa Solà, Faouzi Saliba, Pavel Strnad, Stefan Zeuzem, Miguel Á. Rodríguez, David Semela, Peter Lykke Eriksen, Anna Curto, Rajiv Jalan, Emanuela Ciraci, Alessandra Brocca, István Altorjay, István Tornai, Edilmar Alvarado-Tapias, Jennifer Lehmann, Rajeshwar P. Mookerjee, Paolo Angeli, Rudolf E. Stauber, Ahmed Elsharkawy, Cristina Solé, Didier Samuel, Daniel Markwardt, Maurizio Baldassarre, Cornelius Engelmann, Cesar Jimenez, Pere Ginès, Frederik Nevens, Osagie Akpata, Germán Soriano, Robert Schierwagen, Eleonora Bertoli, Adam Herber, Jörg Tobiasch Moritz, Michael Praktiknjo, Natalie Van den Ende, William Bernal, Nesrine Amari, Stephen D. Ryder, Ana Clemente, Martin Janicko, Victor Vargas, Mattias Mandorfer, Flemming Bendtsen, Peter Jarcuska, Juan Acevedo, Vish Patel, Esau Moreno, Zsuzsanna Vitális, Tamas Tornai, Rafael Bañares, Christian J. Steib, Christian Trautwein, Thomas Berg, Michael Manns, Paolo Caraceni, Jelte J Schaapman, Carlo Alessandria, Carmine Gambino, Salvatore Piano, Carla Pitarch, Thierry Gustot, Osman Ozdogan, Francois Smits, Henning Grønbæk, Giacomo Zaccherini, Cristina Ripoll, Tony Bruns, Jonel Trebicka, Macarena Simón-Talero, Frank Erhard Uschner, Monica Mesquita, PREDICT STUDY Group, EASL-CLIF Consortium, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Banares, Rafael, Janicko, Martin, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Bernal, William, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Bendtsen, Flemming, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, Jose Presa, Sole, Cristina, Soriano, German, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Ozdogan, Osman Cavit, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Shawcross, Debbie, Aguilar, Ferran, Claria, Joan, Ponzo, Paola, Jansen, Christian, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Vargas, Victor, Montagnese, Sara, Alessandria, Carlo, Bernardi, Mauro, Gines, Pere, Jalan, Rajiv, Moreau, Richard, Angeli, Paolo, Arroyo, Vicente, Trebicka J., Fernandez J., Papp M., Caraceni P., Laleman W., Gambino C., Giovo I., Uschner F.E., Jimenez C., Mookerjee R., Gustot T., Albillos A., Banares R., Janicko M., Steib C., Reiberger T., Acevedo J., Gatti P., Bernal W., Zeuzem S., Zipprich A., Piano S., Berg T., Bruns T., Bendtsen F., Coenraad M., Merli M., Stauber R., Zoller H., Ramos J.P., Sole C., Soriano G., de Gottardi A., Gronbaek H., Saliba F., Trautwein C., Ozdogan O.C., Francque S., Ryder S., Nahon P., Romero-Gomez M., Van Vlierberghe H., Francoz C., Manns M., Garcia E., Tufoni M., Amoros A., Pavesi M., Sanchez C., Curto A., Pitarch C., Putignano A., Moreno E., Shawcross D., Aguilar F., Claria J., Ponzo P., Jansen C., Vitalis Z., Zaccherini G., Balogh B., Vargas V., Montagnese S., Alessandria C., Bernardi M., Gines P., Jalan R., Moreau R., Angeli P., Arroyo V., Maschmeier M., Semela D., Elkrief L., Elsharkawy A., Tornai T., Tornai I., Altorjay I., Antognoli A., Baldassarre M., Gagliardi M., Bertoli E., Mareso S., Brocca A., Campion D., Saracco G.M., Rizzo M., Lehmann J., Pohlmann A., Praktiknjo M., Schierwagen R., Sola E., Amari N., Rodriguez M., Nevens F., Clemente A., Jarcuska P., Gerbes A., Mandorfer M., Welsch C., Ciraci E., Patel V., Ripoll C., Herber A., Horn P., Danielsen K.V., Gluud L.L., Schaapman J., Riggio O., Rainer F., Moritz J.T., Mesquita M., Alvarado-Tapias E., Akpata O., Lykke Eriksen P., Samuel D., Tresson S., Strnad P., Amathieu R., Simon-Talero M., Smits F., van den Ende N., Martinez J., Garcia R., Markwardt D., Rupprechter H., and Engelmann C.
Subjects: Liver Cirrhosis, Male, CHRONIC LIVER-FAILURE, Cirrhosis, medicine.medical_treatment, Trasplantament hepàtic, Liver transplantation, Chronic liver disease, Severity of Illness Index, Acute complications, Non-elective admission, Outcome, Risk factors, acute complications, Ascites, Medicine and Health Sciences, Prospective Studies, 610 Medicine & health, Hepatic encephalopathy, Mortality rate, Sciences bio-médicales et agricoles, Middle Aged, Prognosis, Europe, Survival Rate, Hepatic cirrhosis, Portal hypertension, Female, medicine.symptom, medicine.medical_specialty, Cirrosi hepàtica, Gastrointestinal hemorrhage, INFLAMMATION, Internal medicine, Hypertension, Portal, SCORE, medicine, Humans, Decompensation, Hepatology, business.industry, MORTALITY, Acute-On-Chronic Liver Failure, Acute complication, Hemorràgia gastrointestinal, medicine.disease, Human medicine, Hepatic transplantation, business, Follow-Up Studies
Abstract: Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF). The PREDICT study is a European, prospective, observational study, designed to characterize the clinical course of AD and to identify predictors of ACLF., info:eu-repo/semantics/published
Published: 2020
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44. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study

Author: Madotto, F., Pham, T., Bellani, G., Bos, L. D., Simonis, F. D., Fan, E., Artigas, A., Brochard, L., Schultz, M. J., Laffey, J. G., Pesenti, A., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., Ranieri, M., Rubenfeld, G., Thompson, B. T., Wrigge, H., Slutsky, A. S., Rios, F., Van Haren, F., Sottiaux, T., Depuydt, P., Lora, F. S., Azevedo, L. C., Bugedo, G., Qiu, H., Gonzalez, M., Silesky, J., Cerny, V., Nielsen, J., Jibaja, M., Matamis, D., Ranero, J. L., Amin, P., Hashemian, S. M., Clarkson, K., Kurahashi, K., Villagomez, A., Zeggwagh, A. A., Heunks, L. M., Laake, J. H., Palo, J. E., do Vale Fernandes, A., Sandesc, D., Arabi, Y., Bumbasierevic, V., Nin, N., Lorente, J. A., Piquilloud, L., Abroug, F., McNamee, L., Hurtado, J., Bajwa, E., Démpaire, G., Sula, H., Nunci, L., Cani, A., Zazu, A., Dellera, C., Alejandro, R. V., Daldin, J., Vinzio, M., Fernandez, R. O., Cardonnet, L. P., Bettini, L. R., Bisso, M. C., Osman, E. M., Setten, M. G., Lovazzano, P., Alvarez, J., Villar, V., Pozo, N. C., Grubissich, N., Plotnikow, G. A., Vasquez, D. N., Ilutovich, S., Tiribelli, N., Chena, A., Pellegrini, C. A., Saenz, M. G., Estenssoro, E., Brizuela, M., Gianinetto, H., Gomez, P. E., Cerrato, V. I., Bezzi, M. G., Borello, S. A., Loiacono, F. A., Fernandez, A. M., Knowles, S., Reynolds, C., Inskip, D. M., Miller, J. J., Kong, J., Whitehead, C., Bihari, S., Seven, A., Krstevski, A., Rodgers, H. J., Millar, R. T., Mckenna, T. E., Bailey, I. M., Hanlon, G. C., Aneman, A., Lynch, J. M., Azad, R., Neal, J., Woods, P. W., Roberts, B. L., Kol, M. R., Wong, H. S., Riss, K. C., Staudinger, T., Wittebole, X., Berghe, C., Bulpa, P. A., Dive, A. M., Verstraete, R., Lebbinck, H., Vermassen, J., Meersseman, P., Ceunen, H., Rosa, J. I., Beraldo, D. O., Piras, C., Rampinelli, A. M., Nassar A. P., Jr., Mataloun, S., Moock, M., Thompson, M. M., Gonçalves, C. H., Antônio, A. C. P., Ascoli, A., Biondi, R. S., Fontenele, D. C., Nobrega, D., Sales, V. M., Shindhe, S., Ismail, D. M. A. B. P. H., Laffey, J., Beloncle, F., Davies, K. G., Cirone, R., Manoharan, V., Ismail, M., Goligher, E. C., Jassal, M., Nishikawa, E., Javeed, A., Curley, G., Rittayamai, N., Parotto, M., Ferguson, N. D., Mehta, S., Knoll, J., Pronovost, A., Canestrini, S., Bruhn, A. R., Garcia, P. H., Aliaga, F. A., Farías, P. A., Yumha, J. S., Ortiz, C. A., Salas, J. E., Saez, A. A., Vega, L. D., Labarca, E. F., Martinez, F. T., Carreño, N. G., Lora, P., Liu, H., Liu, L., Tang, R., Luo, X., An, Y., Zhao, H., Gao, Y., Zhai, Z., Ye, Z. L., Wang, W., Li, W., Li, Q., Zheng, R., Yu, W., Shen, J., Li, X., Yu, T., Lu, W., Wu, Y. Q., Huang, X. B., He, Z., Lu, Y., Han, H., Zhang, F., Sun, R., Wang, H. X., Qin, S. H., Zhu, B. H., Zhao, J., Liu, J., Li, B., Liu, J. L., Zhou, F. C., Li, Q. J., Zhang, X. Y., Li-Xin, Z., Xin-Hua, Q., Jiang, L., Gao, Y. N., Zhao, X. Y., Li, Y. Y., Li, X. L., Wang, C., Yao, Q., Yu, R., Chen, K., Shao, H., Qin, B., Huang, Q. Q., Zhu, W. H., Hang, A. Y., Hua, M. X., Li, Y., Xu, Y., Di, Y. D., Ling, L. L., Qin, T. H., Wang, S. H., Qin, J., Han, Y., Zhou, S., Vargas, M. P., Jimenez, J. I. S., Rojas, M. A. G., Solis-Quesada, J. E., Ramirez-Alfaro, C. M., Máca, J., Sklienka, P., Gjedsted, J., Christiansen, A., Villamagua, B. G., Llano, M., Burtin, P., Buzancais, G., Beuret, P., Pelletier, N., Mortaza, S., Mercat, A., Chelly, J., Jochmans, S., Terzi, N., Daubin, C., Carteaux, G., de Prost, N., Chiche, J. -D., Daviaud, F., Fartoukh, M., Barberet, G., Biehler, J., Dellamonica, J., Doyen, D., Arnal, J. -M., Briquet, A., Hraiech, S., Papazian, L., Roux, D., Messika, J., Kalaitzis, E., Dangers, L., Combes, A., Au, S. -M., Béduneau, G., Carpentier, D., Zogheib, E. H., Dupont, H., Ricome, S., Santoli, F. L., Besset, S. L., Michel, P., Gelée, B., Danin, P. -E., Goubaux, B., Crova, P. J., Phan, N. T., Berkelmans, F., Badie, J. C., Tapponnier, R., Gally, J., Khebbeb, S., Herbrecht, J. -E., Schneider, F., Declercq, P. -L. M., Rigaud, J. -P., Duranteau, J., Harrois, A., Chabanne, R., Marin, J., Bigot, C., Thibault, S., Ghazi, M., Boukhazna, M., Zein, S. O., Richecoeur, J. R., Combaux, D. M., Grelon, F., Le Moal, C., Sauvadet, E. P., Robine, A., Lemiale, V., Reuter, D., Dres, M., Demoule, A., Goldgran-Toledano, D., Baboi, L., Guérin, C., Lohner, R., Kraßler, J., Schäfer, S., Zacharowski, K. D., Meybohm, P., Reske, A. W., Simon, P., Hopf, H. -B. F., Schuetz, M., Baltus, T., Papanikolaou, M. N., Papavasilopoulou, T. G., Zacharas, G. A., Ourailogloy, V., Mouloudi, E. K., Massa, E. V., Nagy, E. O., Stamou, E. E., Kiourtzieva, E. V., Oikonomou, M. A., Avila, L. E., Cortez, C. A., Citalán, J. E., Jog, S. A., Sable, S. D., Shah, B., Gurjar, M., Baronia, A. K., Memon, M., Muthuchellappan, R., Ramesh, V. J., Shenoy, A., Unnikrishnan, R., Dixit, S. B., Rhayakar, R. V., Ramakrishnan, N., Bhardwaj, V. K., Mahto, H. L., Sagar, S. V., Palaniswamy, V., Ganesan, D., Jamaati, H., Heidari, F., Meaney, E. A., Nichol, A., Knapman, K. M., O’Croinin, D., Dunne, E. S., Breen, D. M., Clarkson, K. P., Jaafar, R. F., Dwyer, R., Amir, F., Ajetunmobi, O. O., O’Muircheartaigh, A. C., Black, C. S., Treanor, N., Collins, D. V., Altaf, W., Zani, G., Fusari, M., Spadaro, S., Volta, C. A., Graziani, R., Brunettini, B., Palmese, S., Formenti, P., Umbrello, M., Lombardo, A., Pecci, E., Botteri, M., Savioli, M., Protti, A., Mattei, A., Schiavoni, L., Tinnirello, A., Todeschini, M., Giarratano, A., Cortegiani, A., Sher, S., Rossi, A., Antonelli, M. M., Montini, L. M., Casalena, P., Scafetti, S., Panarello, G., Occhipinti, G., Patroniti, N., Pozzi, M., Biscione, R. R., Poli, M. M., Raimondi, F., Albiero, D., Crapelli, G., Beck, E., Pota, V., Schiavone, V., Molin, A., Tarantino, F., Monti, G., Frati, E., Mirabella, L., Cinnella, G., Fossali, T., Colombo, R., Pattarino, P. T. I., Mojoli, F., Braschi, A., Borotto, E. E., Cracchiolo, A. N., Palma, D. M., Raponi, F., Foti, G., Vascotto, E. R., Coppadoro, A., Brazzi, L., Floris, L., Iotti, G. A., Venti, A., Yamaguchi, O., Takagi, S., Maeyama, H. N., Watanabe, E., Yamaji, Y., Shimizu, K., Shiozaki, K., Futami, S., Ryosuke, S., Saito, K., Kameyama, Y., Ueno, K., Izawa, M., Okuda, N., Suzuki, H., Harasawa, T., Nasu, M., Takada, T., Ito, F., Nunomiya, S., Koyama, K., Abe, T., Andoh, K., Kusumoto, K., Hirata, A., Takaba, A., Kimura, H., Matsumoto, S., Higashijima, U., Honda, H., Aoki, N., Imai, H., Ogino, Y., Mizuguchi, I., Ichikado, K., Nitta, K., Mochizuki, K., Hashida, T., Tanaka, H., Nakamura, T., Niimi, D., Ueda, T., Kashiwa, Y., Uchiyama, A., Sabelnikovs, O., Oss, P., Haddad, Y., Liew, K. Y., Ñamendys-Silva, S. A., Jarquin-Badiola, Y. D., Sanchez-Hurtado, L. A., Gomez-Flores, S. S., Marin, M. C., Villagomez, A. J., Lemus, J. S., Fierro, J. M., Cervantes, M. R., Mejia, F. J. F., Dector, D., Dector, D. M., Gonzalez, D. R., Estrella, C. R., Sanchez-Medina, J. R., Ramirez-Gutierrez, A., George, F. G., Aguirre, J. S., Buensuseso, J. A., Poblano, M., Dendane, T., Balkhi, H., Elkhayari, M., Samkaoui, N., Ezzouine, H., Benslama, A., Amor, M., Maazouzi, W., Cimic, N., Beck, O., Bruns, M. M., Schouten, J. A., Rinia, M., Raaijmakers, M., Van Wezel, H. M., Heines, S. J., Strauch, U., Buise, M. P., Goodson, J. C., Browne, T. S., Navarra, L., Hunt, A., Hutchison, R. A., Bailey, M. B., Newby, L., Mcarthur, C., Kalkoff, M., Mcleod, A., Casement, J., Hacking, D. J., Andersen, F. H., Dolva, M. S., Barratt-Due, A., Noremark, K. A. L., Søreide, E., Sjøbø, B. Å., Guttormsen, A. B., Yoshido, H. H. L., Aguilar, R. Z., Oscanoa, F. A. M., Alisasis, A. U., Robles, J. B., Pasanting-Lim, R. A. B., Tan, B. C., Andruszkiewicz, P., Jakubowska, K., Coxo, C. M., Alvarez, A. M., Oliveira, B. S., Montanha, G. M., Barros, N. C., Pereira, C. S., Messias, A. M., Monteiro, J. M., Araujo, A. M., Catorze, N. T., Marum, S. M., Bouw, M. J., Gomes, R. M., Brito, V. A., Castro, S., Estilita, J. M., Barros, F. M., Serra, I. M., Martinho, A. M., Tomescu, D. R., Marcu, A., Bedreag, O. H., Papurica, M., Corneci, D. E., Negoita, S. L., Grigoriev, E., Gritsan, A. I., Gazenkampf, A. A., Almekhlafi, G., Albarrak, M. M., Mustafa, G. M., Maghrabi, K. A., Salahuddin, N., Aisa, T. M., Jabbary, A. S. A., Tabhan, E., Arabi, Y. M., Trinidad, O. A., Dorzi, H. M. A., Tabhan, E. E., Bolon, S., Smith, O., Mancebo, J., Aguirre-Bermeo, H., Lopez-Delgado, J. C., Esteve, F., Rialp, G., Forteza, C., De Haro, C., Albaiceta, G. M., De Cima-Iglesias, S., Seoane-Quiroga, L., Ceniceros-Barros, A., Ruiz-Aguilar, A. L., Claraco-Vega, L. M., Soler, J. A., del Carmen Lorente, M., Hermosa, C., Gordo, F., Prieto-González, M., López-Messa, J. B., Perez, M. P., Perez, C. P., Allue, R. M., Roche-Campo, F., Ibañez-Santacruz, M., Temprano, S., Pintado, M. C., De Pablo, R., Gómez, P. R. A., Ruiz, S. R., Moles, S. I., Jurado, M. ªT., Arizmendi, A., Piacentini, E. A., Franco, N., Honrubia, T., Cheng, M. P., Losada, E. P., Blanco, J., Yuste, L. J., Carbayo-Gorriz, C., Cazorla-Barranquero, F. G., Alonso, J. G., Alda, R. S., Algaba, Á., Navarro, G., Cereijo, E., Diaz-Rodriguez, E., Marcos, D. P., Montero, L. A., Para, L. H., Sanchez, R. J., Navalpotro, M. A. B., Abad, R. D., González, R. M., Toribio, D. P., Castro, A. G., Artiga, M. J. D., Penuelas, O., Roser, T. P., Olga, M. F., Curto, E. G., Sánchez, R. M., Imma, V. P., Elisabet, G. M., Claverias, L., Magret, M., Pellicer, A. M., Rodriguez, L. L., Sánchez-Ballesteros, J., González-Salamanca, Á., Jimenez, A. G., Huerta, F. P., Diaz, J. C. J. S., Lopez, E. B., Moya, D. D. L., Alfonso, A. A. T., Luis, P. S. E., Cesar, P. S., Rafael, S. I., Virgilio, C. G., Recio, N. N., Adamsson, R. O., Rylander, C. C., Holzgraefe, B., Broman, L. M., Wessbergh, J., Persson, L., Schiöler, F., Kedelv, H., Tibblin, A. O., Appelberg, H., Hedlund, L., Helleberg, J., Eriksson, K. 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L., Ioannou, N., Gillis, S., Csabi, P., Macfadyen, R., Dawson, H., Preez, P. D., Williams, A. J., Boyd, O., De Gordoa, L. O. -R., Bramall, J., Symmonds, S., Chau, S. K., Wenham, T., Szakmany, T., Toth-Tarsoly, P., McCalman, K. H., Alexander, P., Stephenson, L., Collyer, T., Chapman, R., Cooper, R., Allan, R. M., Sim, M., Wrathall, D. W., Irvine, D. A., Zantua, K. S., Adams, J. C., Burtenshaw, A. J., Sellors, G. P., Welters, I. D., Williams, K. E., Hessell, R. J., Oldroyd, M. G., Battle, C. E., Pillai, S., Kajtor, I., Sivashanmugavel, M., O’Kane, S. C., Donnelly, A., Frigyik, A. D., Careless, J. P., May, M. M., Stewart, R., Trinder, T. J., Hagan, S. J., Wise, M. P., Cole, J. M., MacFie, C. C., Dowling, A. T., Nuñez, E., Pittini, G., Rodriguez, R., Imperio, M. C., Santos, C., França, A. G., Ebeid, A., Deicas, A., Serra, C., Uppalapati, A., Kamel, G., Banner-Goodspeed, V. M., Beitler, J. R., Mukkera, S. R., Kulkarni, S., Lee, J., Mesar, T., Shinn, J. 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L., Schomer, A., Bumbasirevic, V., Jovanovic, B., Surbatovic, M., Veljovic, M., LUNG SAFE Investigators and the ESICM Trials Group, Madotto, F., Pham, T., Bellani, G., Bos, L.D., Simonis, F.D., Fan, E., Artigas, A., Brochard, L., Schultz, M.J., Laffey, J.G., Pesenti, A., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D.F., Ranieri, M., Rubenfeld, G., Thompson, B.T., Wrigge, H., Slutsky, A.S., Rios, F., Van Haren, F., Sottiaux, T., Depuydt, P., Lora, F.S., Azevedo, L.C., Bugedo, G., Qiu, H., Gonzalez, M., Silesky, J., Cerny, V., Nielsen, J., Jibaja, M., Matamis, D., Ranero, J.L., Amin, P., Hashemian, S.M., Clarkson, K., Kurahashi, K., Villagomez, A., Zeggwagh, A.A., Heunks, L.M., Laake, J.H., Palo, J.E., do Vale Fernandes, A., Sandesc, D., Arabi, Y., Bumbasierevic, V., Nin, N., Lorente, J.A., Piquilloud, L., Abroug, F., McNamee, L., Hurtado, J., Bajwa, E., Démpaire, G., Sula, H., Nunci, L., Cani, A., Zazu, A., Dellera, C., Alejandro, R.V., Daldin, J., Vinzio, M., 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Schomer, A., Bumbasirevic, V., Jovanovic, B., Surbatovic, M., Veljovic, M., LUNG SAFE Investigators and the ESICM Trials Group, Madotto, F, Pham, T, Bellani, G, Bos, L, Simonis, F, Fan, E, Artigas, A, Brochard, L, Schultz, M, Laffey, J, Pesenti, A, Esteban, A, Gattinoni, L, van Haren, F, Larsson, A, Mcauley, D, Ranieri, M, Rubenfeld, G, Thompson, B, Wrigge, H, Slutsky, A, Rios, F, Sottiaux, T, Depuydt, P, Lora, F, Azevedo, L, Bugedo, G, Qiu, H, Gonzalez, M, Silesky, J, Cerny, V, Nielsen, J, Jibaja, M, Matamis, D, Ranero, J, Amin, P, Hashemian, S, Clarkson, K, Kurahashi, K, Villagomez, A, Zeggwagh, A, Heunks, L, Laake, J, Palo, J, Do Vale Fernandes, A, Sandesc, D, Arabi, Y, Bumbasierevic, V, Nin, N, Lorente, J, Piquilloud, L, Abroug, F, Mcnamee, L, Hurtado, J, Bajwa, E, Démpaire, G, Sula, H, Nunci, L, Cani, A, Zazu, A, Dellera, C, Alejandro, R, Daldin, J, Vinzio, M, Fernandez, R, Cardonnet, L, Bettini, L, Bisso, M, Osman, E, Setten, M, Lovazzano, P, Alvarez, J, Villar, V, Pozo, N, Grubissich, N, Plotnikow, G, Vasquez, D, Ilutovich, S, Tiribelli, N, Chena, A, Pellegrini, C, Saenz, M, Estenssoro, E, Brizuela, M, Gianinetto, H, Gomez, P, Cerrato, V, Bezzi, M, Borello, S, Loiacono, F, Fernandez, A, Knowles, S, Reynolds, C, Inskip, D, Miller, J, Kong, J, Whitehead, C, Bihari, S, Seven, A, Krstevski, A, Rodgers, H, Millar, R, Mckenna, T, Bailey, I, Hanlon, G, Aneman, A, Lynch, J, Azad, R, Neal, J, Woods, P, Roberts, B, Kol, M, Wong, H, Riss, K, Staudinger, T, Wittebole, X, Berghe, C, Bulpa, P, Dive, A, Verstraete, R, Lebbinck, H, Vermassen, J, Meersseman, P, Ceunen, H, Rosa, J, Beraldo, D, Piras, C, Rampinelli, A, Nassar, A, Mataloun, S, Moock, M, Thompson, M, Gonçalves, C, Antônio, A, Ascoli, A, Biondi, R, Fontenele, D, Nobrega, D, Sales, V, Shindhe, S, Ismail, D, Beloncle, F, Davies, K, Cirone, R, Manoharan, V, Ismail, M, Goligher, E, Jassal, M, Nishikawa, E, Javeed, A, Curley, G, Rittayamai, N, Parotto, M, Ferguson, N, Mehta, S, Knoll, J, Pronovost, A, Canestrini, S, Bruhn, A, Garcia, P, Aliaga, F, Farías, P, Yumha, J, Ortiz, C, Salas, J, Saez, A, Vega, L, Labarca, E, Martinez, F, Carreño, N, Lora, P, Liu, H, Liu, L, Tang, R, Luo, X, An, Y, Zhao, H, Gao, Y, Zhai, Z, Ye, Z, Wang, W, Li, W, Li, Q, Zheng, R, Yu, W, Shen, J, Li, X, Yu, T, Lu, W, Wu, Y, Huang, X, He, Z, Lu, Y, Han, H, Zhang, F, Sun, R, Wang, H, Qin, S, Zhu, B, Zhao, J, Liu, J, Li, B, Zhou, F, Zhang, X, Li-Xin, Z, Xin-Hua, Q, Jiang, L, Zhao, X, Li, Y, Wang, C, Yao, Q, Yu, R, Chen, K, Shao, H, Qin, B, Huang, Q, Zhu, W, Hang, A, Hua, M, Xu, Y, Di, Y, Ling, L, Qin, T, Wang, S, Qin, J, Han, Y, Zhou, S, Vargas, M, Jimenez, J, Rojas, M, Solis-Quesada, J, Ramirez-Alfaro, C, Máca, J, Sklienka, P, Gjedsted, J, Christiansen, A, Villamagua, B, Llano, M, Burtin, P, Buzancais, G, Beuret, P, Pelletier, N, Mortaza, S, Mercat, A, Chelly, J, Jochmans, S, Terzi, N, Daubin, C, Carteaux, G, de Prost, N, Chiche, J, Daviaud, F, Fartoukh, M, Barberet, G, Biehler, J, Dellamonica, J, Doyen, D, Arnal, J, Briquet, A, Hraiech, S, Papazian, L, Roux, D, Messika, J, Kalaitzis, E, Dangers, L, Combes, A, Au, S, Béduneau, G, Carpentier, D, Zogheib, E, Dupont, H, Ricome, S, Santoli, F, Besset, S, Michel, P, Gelée, B, Danin, P, Goubaux, B, Crova, P, Phan, N, Berkelmans, F, Badie, J, Tapponnier, R, Gally, J, Khebbeb, S, Herbrecht, J, Schneider, F, Declercq, P, Rigaud, J, Duranteau, J, Harrois, A, Chabanne, R, Marin, J, Bigot, C, Thibault, S, Ghazi, M, Boukhazna, M, Zein, S, Richecoeur, J, Combaux, D, Grelon, F, Le Moal, C, Sauvadet, E, Robine, A, Lemiale, V, Reuter, D, Dres, M, Demoule, A, Goldgran-Toledano, D, Baboi, L, Guérin, C, Lohner, R, Kraßler, J, Schäfer, S, Zacharowski, K, Meybohm, P, Reske, A, Simon, P, Hopf, H, Schuetz, M, Baltus, T, Papanikolaou, M, Papavasilopoulou, T, Zacharas, G, Ourailogloy, V, Mouloudi, E, Massa, E, Nagy, E, Stamou, E, Kiourtzieva, E, Oikonomou, M, Avila, L, Cortez, C, Citalán, J, Jog, S, Sable, S, Shah, B, Gurjar, M, Baronia, A, Memon, M, Muthuchellappan, R, Ramesh, V, Shenoy, A, Unnikrishnan, R, Dixit, S, Rhayakar, R, Ramakrishnan, N, Bhardwaj, V, Mahto, H, Sagar, S, Palaniswamy, V, Ganesan, D, Jamaati, H, Heidari, F, Meaney, E, Nichol, A, Knapman, K, O’Croinin, D, Dunne, E, Breen, D, Jaafar, R, Dwyer, R, Amir, F, Ajetunmobi, O, O’Muircheartaigh, A, Black, C, Treanor, N, Collins, D, Altaf, W, Zani, G, Fusari, M, Spadaro, S, Volta, C, Graziani, R, Brunettini, B, Palmese, S, Formenti, P, Umbrello, M, Lombardo, A, Pecci, E, Botteri, M, Savioli, M, Protti, A, Mattei, A, Schiavoni, L, Tinnirello, A, Todeschini, M, Giarratano, A, Cortegiani, A, Sher, S, Rossi, A, Antonelli, M, Montini, L, Casalena, P, Scafetti, S, Panarello, G, Occhipinti, G, Patroniti, N, Pozzi, M, Biscione, R, Poli, M, Raimondi, F, Albiero, D, Crapelli, G, Beck, E, Pota, V, Schiavone, V, Molin, A, Tarantino, F, Monti, G, Frati, E, Mirabella, L, Cinnella, G, Fossali, T, Colombo, R, Pattarino, P, Mojoli, F, Braschi, A, Borotto, E, Cracchiolo, A, Palma, D, Raponi, F, Foti, G, Vascotto, E, Coppadoro, A, Brazzi, L, Floris, L, Iotti, G, Venti, A, Yamaguchi, O, Takagi, S, Maeyama, H, Watanabe, E, Yamaji, Y, Shimizu, K, Shiozaki, K, Futami, S, Ryosuke, S, Saito, K, Kameyama, Y, Ueno, K, Izawa, M, Okuda, N, Suzuki, H, Harasawa, T, Nasu, M, Takada, T, Ito, F, Nunomiya, S, Koyama, K, Abe, T, Andoh, K, Kusumoto, K, Hirata, A, Takaba, A, Kimura, H, Matsumoto, S, Higashijima, U, Honda, H, Aoki, N, Imai, H, Ogino, Y, Mizuguchi, I, Ichikado, K, Nitta, K, Mochizuki, K, Hashida, T, Tanaka, H, Nakamura, T, Niimi, D, Ueda, T, Kashiwa, Y, Uchiyama, A, Sabelnikovs, O, Oss, P, Haddad, Y, Liew, K, Ñamendys-Silva, S, Jarquin-Badiola, Y, Sanchez-Hurtado, L, Gomez-Flores, S, Marin, M, Lemus, J, Fierro, J, Cervantes, M, Mejia, F, Dector, D, Gonzalez, D, Estrella, C, Sanchez-Medina, J, Ramirez-Gutierrez, A, George, F, Aguirre, J, Buensuseso, J, Poblano, M, Dendane, T, Balkhi, H, Elkhayari, M, Samkaoui, N, Ezzouine, H, Benslama, A, Amor, M, Maazouzi, W, Cimic, N, Beck, O, Bruns, M, Schouten, J, Rinia, M, Raaijmakers, M, van Wezel, H, Heines, S, Strauch, U, Buise, M, Goodson, J, Browne, T, Navarra, L, Hunt, A, Hutchison, R, Bailey, M, Newby, L, Mcarthur, C, Kalkoff, M, Mcleod, A, Casement, J, Hacking, D, Andersen, F, Dolva, M, Barratt-Due, A, Noremark, K, Søreide, E, Sjøbø, B, Guttormsen, A, Yoshido, H, Aguilar, R, Oscanoa, F, Alisasis, A, Robles, J, Pasanting-Lim, R, Tan, B, Andruszkiewicz, P, Jakubowska, K, Coxo, C, Alvarez, A, Oliveira, B, Montanha, G, Barros, N, Pereira, C, Messias, A, Monteiro, J, Araujo, A, Catorze, N, Marum, S, Bouw, M, Gomes, R, Brito, V, Castro, S, Estilita, J, Barros, F, Serra, I, Martinho, A, Tomescu, D, Marcu, A, Bedreag, O, Papurica, M, Corneci, D, Negoita, S, Grigoriev, E, Gritsan, A, Gazenkampf, A, Almekhlafi, G, Albarrak, M, Mustafa, G, Maghrabi, K, Salahuddin, N, Aisa, T, Jabbary, A, Tabhan, E, Trinidad, O, Dorzi, H, Bolon, S, Smith, O, Mancebo, J, Aguirre-Bermeo, H, Lopez-Delgado, J, Esteve, F, Rialp, G, Forteza, C, de Haro, C, Albaiceta, G, de Cima-Iglesias, S, Seoane-Quiroga, L, Ceniceros-Barros, A, Ruiz-Aguilar, A, Claraco-Vega, L, Soler, J, Del Carmen Lorente, M, Hermosa, C, Gordo, F, Prieto-González, M, López-Messa, J, Perez, M, Perez, C, Allue, R, Roche-Campo, F, Ibañez-Santacruz, M, Temprano, S, Pintado, M, de Pablo, R, Gómez, P, Ruiz, S, Moles, S, Jurado, M, Arizmendi, A, Piacentini, E, Franco, N, Honrubia, T, Cheng, M, Losada, E, Blanco, J, Yuste, L, Carbayo-Gorriz, C, Cazorla-Barranquero, F, Alonso, J, Alda, R, Algaba, Á, Navarro, G, Cereijo, E, Diaz-Rodriguez, E, Marcos, D, Montero, L, Para, L, Sanchez, R, Navalpotro, M, Abad, R, González, R, Toribio, D, Castro, A, Artiga, M, Penuelas, O, Roser, T, Olga, M, Curto, E, Sánchez, R, Imma, V, Elisabet, G, Claverias, L, Magret, M, Pellicer, A, Rodriguez, L, Sánchez-Ballesteros, J, González-Salamanca, Á, Jimenez, A, Huerta, F, Diaz, J, Lopez, E, Moya, D, Alfonso, A, Luis, P, Cesar, P, Rafael, S, Virgilio, C, Recio, N, Adamsson, R, Rylander, C, Holzgraefe, B, Broman, L, Wessbergh, J, Persson, L, Schiöler, F, Kedelv, H, Tibblin, A, Appelberg, H, Hedlund, L, Helleberg, J, Eriksson, K, Glietsch, R, Larsson, N, Nygren, I, Nunes, S, Morin, A, Kander, T, Adolfsson, A, Zender, H, Leemann-Refondini, C, Elatrous, S, Bouchoucha, S, Chouchene, I, Ouanes, I, Souissi, A, Kamoun, S, Demirkiran, O, Aker, M, Erbabacan, E, Ceylan, I, Girgin, N, Ozcelik, M, Ünal, N, Meco, B, Akyol, O, Derman, S, Kennedy, B, Parhar, K, Srinivasa, L, Hopkins, P, Mellis, C, Kakar, V, Hadfield, D, Vercueil, A, Bhowmick, K, Humphreys, S, Ferguson, A, Mckee, R, Raj, A, Fawkes, D, Watt, P, Twohey, L, Thomas, R, Morton, A, Kadaba, V, Smith, M, Hormis, A, Kannan, S, Namih, M, Reschreiter, H, Camsooksai, J, Kumar, A, Rugonfalvi, S, Nutt, C, O’Neill, O, Seasman, C, Dempsey, G, Scott, C, Ellis, H, Mckechnie, S, Hutton, P, Di Tomasso, N, Vitale, M, Griffin, R, Dean, M, Cranshaw, J, Willett, E, Ioannou, N, Gillis, S, Csabi, P, Macfadyen, R, Dawson, H, Preez, P, Williams, A, Boyd, O, de Gordoa, L, Bramall, J, Symmonds, S, Chau, S, Wenham, T, Szakmany, T, Toth-Tarsoly, P, Mccalman, K, Alexander, P, Stephenson, L, Collyer, T, Chapman, R, Cooper, R, Allan, R, Sim, M, Wrathall, D, Irvine, D, Zantua, K, Adams, J, Burtenshaw, A, Sellors, G, Welters, I, Williams, K, Hessell, R, Oldroyd, M, Battle, C, Pillai, S, Kajtor, I, Sivashanmugavel, M, O’Kane, S, Donnelly, A, Frigyik, A, Careless, J, May, M, Stewart, R, Trinder, T, Hagan, S, Wise, M, Cole, J, Macfie, C, Dowling, A, Nuñez, E, Pittini, G, Rodriguez, R, Imperio, M, Santos, C, França, A, Ebeid, A, Deicas, A, Serra, C, Uppalapati, A, Kamel, G, Banner-Goodspeed, V, Beitler, J, Mukkera, S, Kulkarni, S, Lee, J, Mesar, T, Shinn, J, Gomaa, D, Tainter, C, Yeatts, D, Warren, J, Lanspa, M, Miller, R, Grissom, C, Brown, S, Bauer, P, Gosselin, R, Kitch, B, Cohen, J, Beegle, S, Gueret, R, Tulaimat, A, Choudry, S, Stigler, W, Batra, H, Huff, N, Lamb, K, Oetting, T, Mohr, N, Judy, C, Saito, S, Kheir, F, Schlichting, A, Delsing, A, Crouch, D, Elmasri, M, Dreyer, K, Blakeman, T, Baron, R, Grijalba, C, Hou, P, Seethala, R, Aisiku, I, Henderson, G, Frendl, G, Hou, S, Owens, R, Schomer, A, Bumbasirevic, V, Jovanovic, B, Surbatovic, M, Veljovic, M, Madotto, Fabiana, Pham, Tài, Bellani, Giacomo, Bos, Lieuwe D., Simonis, Fabienne D., Fan, Eddy, Artigas, Antonio, Brochard, Laurent, Schultz, Marcus J., Laffey, John G., Pesenti, Antonio, Esteban, Andre, Gattinoni, Luciano, van Haren, Frank, Larsson, Ander, McAuley, Daniel F., Ranieri, Marco, Rubenfeld, Gordon, Thompson, B. Taylor, Wrigge, Hermann, Slutsky, Arthur S., Rios, Fernando, Lora, Fredy S., Azevedo, Luciano Cesar, Bugedo, Guillermo, Qiu, Haibo, Gonzalez, Marco, Silesky, Juan, Cerny, Vladimir, Nielsen, Jona, Jibaja, Manuel, Matamis, Dimitrio, Ranero, Jorge Lui, Amin, Pravin, Clarkson, Kevin, Kurahashi, Kiyoyasu, Villagomez, Asisclo, Zeggwagh, Amine Ali, Heunks, Leo M., Laake, Jon Henrik, Palo, Jose Emmanuel, Do Vale Fernandes, Antero, Sandesc, Dorel, Arabi, Yaasen, Bumbasierevic, Vesna, Nin, Nicola, Lorente, Jose A., Piquilloud, Lise, Abroug, Fekri, McNamee, Lia, Hurtado, Javier, Bajwa, Ed, Démpaire, Gabriel, Sula, Hektor, Nunci, Lordian, Cani, Alma, Zazu, Alan, Dellera, Christian, Alejandro, Risso V., Daldin, Julio, Vinzio, Mauricio, Fernandez, Ruben O., Cardonnet, Luis P., Bettini, Lisandro R., Bisso, Mariano Carboni, Osman, Emilio M., Setten, Mariano G., Lovazzano, Pablo, Alvarez, Javier, Villar, Veronica, Pozo, Norberto C., Grubissich, Nicola, Plotnikow, Gustavo A., Vasquez, Daniela N., Ilutovich, Santiago, Tiribelli, Norberto, Chena, Ariel, Pellegrini, Carlos A., Saenz, María G., Estenssoro, Elisa, Brizuela, Matia, Gianinetto, Hernan, Gomez, Pablo E., Cerrato, Valeria I., Bezzi, Marco G., Borello, Silvina A., Loiacono, Flavia A., Fernandez, Adriana M., Knowles, Serena, Reynolds, Claire, Inskip, Deborah M., Miller, Jennene J., Kong, Jing, Whitehead, Christina, Bihari, Shailesh, Seven, Aylin, Krstevski, Amanda, Rodgers, Helen J., Millar, Rebecca T., Mckenna, Toni E., Bailey, Irene M., Hanlon, Gabrielle C., Aneman, Ander, Lynch, Joan M., Azad, Raman, Neal, John, Woods, Paul W., Roberts, Brigit L., Kol, Mark R., Wong, Helen S., Riss, Katharina C., Staudinger, Thoma, Wittebole, Xavier, Berghe, Caroline, Bulpa, Pierre A., Dive, Alain M., Verstraete, Rik, Lebbinck, Herve, Depuydt, Pieter, Vermassen, Jori, Meersseman, Philippe, Ceunen, Helga, Rosa, Jonas I., Beraldo, Daniel O., Piras, Claudio, Rampinelli, Adenilton M., Nassar, Antonio P., Mataloun, Sergio, Moock, Marcelo, Thompson, Marlus M., Gonçalves, Claudio H., Antônio, Ana Carolina P., Ascoli, Aline, Biondi, Rodrigo S., Fontenele, Danielle C., Nobrega, Danielle, Sales, Vanessa M., Shindhe, Suresh, Ismail, Dk Maizatul Aiman B. Pg Hj, Laffey, John, Beloncle, Francoi, Davies, Kyle G., Cirone, Rob, Manoharan, Venika, Ismail, Mehvish, Goligher, Ewan C., Jassal, Mandeep, Nishikawa, Erin, Javeed, Areej, Curley, Gerard, Rittayamai, Nuttapol, Parotto, Matteo, Ferguson, Niall D., Mehta, Sangeeta, Knoll, Jenny, Pronovost, Antoine, Canestrini, Sergio, Bruhn, Alejandro R., Garcia, Patricio H., Aliaga, Felipe A., Farías, Pamela A., Yumha, Jacob S., Ortiz, Claudia A., Salas, Javier E., Saez, Alejandro A., Vega, Luis D., Labarca, Eduardo F., Martinez, Felipe T., Carreño, Nicolás G., Lora, Pilar, Liu, Haitao, Liu, Ling, Tang, Rui, Luo, Xiaoming, An, Youzhong, Zhao, Huiying, Gao, Yan, Zhai, Zhe, Ye, Zheng L., Wang, Wei, Li, Wenwen, Li, Qingdong, Zheng, Ruiqiang, Yu, Wenkui, Shen, Juanhong, Li, Xinyu, Yu, Tao, Lu, Weihua, Wu, Ya, Huang, Xiao B., He, Zhenyang, Lu, Yuanhua, Han, Hui, Zhang, Fan, Sun, Renhua, Wang, Hua X., Qin, Shu H., Zhu, Bao H., Zhao, Jun, Liu, Jian, Li, Bin, Liu, Jing L., Zhou, Fa, Li, Qiong J., Zhang, Xing Y., Li-Xin, Zhou, Xin-Hua, Qiang, Jiang, Liangyan, Gao, Yuan N., Zhao, Xian Y., Li, Yuan Y., Li, Xiao L., Wang, Chunting, Yao, Qingchun, Yu, Rongguo, Chen, Kai, Shao, Huanzhang, Qin, Bingyu, Huang, Qing Q., Zhu, Wei H., Hang, Ai, Hua, Ma, Li, Yimin, Xu, Yonghao, Di, Yu, Ling, Long L., Qin, Tie H., Wang, Shou H., Qin, Junping, Han, Yi, Zhou, Suming, Vargas, Monica P., Jimenez, Juan I. Silesky, Rojas, Manuel A. González, Solis-Quesada, Jaime E., Ramirez-Alfaro, Christian M., Máca, Jan, Sklienka, Peter, Gjedsted, Jakob, Christiansen, Aage, Villamagua, Boris G., Llano, Miguel, Burtin, Philippe, Buzancais, Gautier, Beuret, Pascal, Pelletier, Nicola, Mortaza, Satar, Mercat, Alain, Chelly, Jonathan, Jochmans, Sébastien, Terzi, Nicola, Daubin, Cédric, Carteaux, Guillaume, de Prost, Nicola, Chiche, Jean-Daniel, Daviaud, Fabrice, Pham, Tai, Fartoukh, Muriel, Barberet, Guillaume, Biehler, Jerome, Dellamonica, Jean, Doyen, Deni, Arnal, Jean-Michel, Briquet, Anai, Hraiech, Sami, Papazian, Laurent, Roux, Damien, Messika, Jonathan, Kalaitzis, Evangelo, Dangers, Laurence, Combes, Alain, Au, Siu-Ming, Béduneau, Gaetan, Carpentier, Dorothée, Zogheib, Elie H., Dupont, Herve, Ricome, Sylvie, Santoli, Francesco L., Besset, Sebastien L., Michel, Philippe, Gelée, Bruno, Danin, Pierre-Eric, Goubaux, Bernard, Crova, Philippe J., Phan, Nga T., Berkelmans, Frantz, Badie, Julio C., Tapponnier, Romain, Gally, Josette, 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C., Ferguson, N. D., Bruhn, A. R., Garcia, P. H., Aliaga, F. A., Farias, P. A., Yumha, J. S., Ortiz, C. A., Salas, J. E., Saez, A. A., Vega, L. D., Labarca, E. F., Martinez, F. T., Carreno, N. G., Ye, Z. L., Wu, Y. Q., Huang, X. B., Wang, H. X., Qin, S. H., Zhu, B. H., Liu, J. L., Zhou, F. C., Li, Q. J., Zhang, X. Y., Gao, Y. N., Zhao, X. Y., Li, Y. Y., Li, X. L., Huang, Q. Q., Zhu, W. H., Hang, A. Y., Hua, M. X., Di, Y. D., Ling, L. L., Qin, T. H., Wang, S. H., Vargas, M. P., Jimenez, J. I. S., Rojas, M. A. G., Solis-Quesada, J. E., Ramirez-Alfaro, C. M., Maca, J., Villamagua, B. G., Chiche, J. -D., Arnal, J. -M., Au, S. -M., Beduneau, G., Zogheib, E. H., Santoli, F. L., Besset, S. L., Gelee, B., Danin, P. -E., Crova, P. J., Phan, N. T., Badie, J. C., Herbrecht, J. -E., Declercq, P. -L. M., Rigaud, J. -P., Zein, S. O., Richecoeur, J. R., Combaux, D. M., Lemoal, C., Sauvadet, E. P., Guerin, C., Krassler, J., Schafer, S., Zacharowski, K. D., Reske, A. W., Hopf, H. -B. F., Papanikolaou, M. N., Papavasilopoulou, T. G., Zacharas, G. A., Mouloudi, E. K., Massa, E. V., Nagy, E. O., Stamou, E. E., Kiourtzieva, E. V., Oikonomou, M. A., Avila, L. E., Cortez, C. A., Citalan, J. E., Jog, S. A., Sable, S. D., Baronia, A. K., Ramesh, V. J., Dixit, S. B., Rhayakar, R. V., Bhardwaj, V. K., Mahto, H. L., Sagar, S. V., Meaney, E. A., Knapman, K. M., O'Croinin, D., Dunne, E. S., Breen, D. M., Clarkson, K. P., Jaafar, R. F., Ajetunmobi, O. O., O'Muircheartaigh, A. C., Black, C. S., Collins, D. V., Volta, C. A., Antonelli, M. M., Montini, L. M., Biscione, R. R., Poli, M. M., Pattarino, P. T. I., Borotto, E. E., Cracchiolo, A. N., Palma, D. M., Vascotto, E. R., Iotti, G. A., Maeyama, H. N., Liew, K. Y., Namendys-Silva, S. A., Jarquin-Badiola, Y. D., Sanchez-Hurtado, L. A., Gomez-Flores, S. S., Marin, M. C., Villagomez, A. J., Lemus, J. S., Fierro, J. M., Cervantes, M. R., Mejia, F. J. F., Dector, D. M., Gonzalez, D. R., Estrella, C. R., Sanchez-Medina, J. 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M., Ruiz-Aguilar, A. L., Claraco-Vega, L. M., Soler, J. A., Prieto-Gonzalez, M., Lopez-Messa, J. B., Perez, M. P., Perez, C. P., Allue, R. M., Ibanez-Santacruz, M., Pintado, M. C., Depablo, R., Gomez, P. R. A., Ruiz, S. R., Moles, S. I., Jurado, M. T., Piacentini, E. A., Cheng, M. P., Losada, E. P., Yuste, L. J., Cazorla-Barranquero, F. G., Alonso, J. G., Alda, R. S., Algaba, A., Marcos, D. P., Montero, L. A., Para, L. H., Sanchez, R. J., Navalpotro, M. A. B., Abad, R. D., Gonzalez, R. M., Toribio, D. P., Castro, A. G., Artiga, M. J. D., Roser, T. P., Olga, M. F., Curto, E. G., Sanchez, R. M., Imma, V. P., Elisabet, G. M., Pellicer, A. M., Rodriguez, L. L., Sanchez-Ballesteros, J., Gonzalez-Salamanca, A., Jimenez, A. G., Huerta, F. P., Diaz, J. C. J. S., Lopez, E. B., Moya, D. D. L., Alfonso, A. A. T., Luis, P. S. E., Cesar, P. S., Rafael, S. I., Virgilio, C. G., Recio, N. N., Adamsson, R. O., Rylander, C. C., Broman, L. M., Schioler, F., Tibblin, A. O., Eriksson, K. E., Nunes, S. 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K., Brown, S. M., Bauer, P. R., Gosselin, R. J., Kitch, B. T., Cohen, J. E., Beegle, S. H., Gueret, R. M., Huff, N. G., Lamb, K. D., Oetting, T. W., Mohr, N. M., Kheir, F. M., Schlichting, A. B., Crouch, D. R., Dreyer, K. R., Blakeman, T. C., Baron, R. M., Grijalba, C. Q., Hou, P. C., Hou, S. -K., and Owens, R. L.
Subjects: Male, ARDS, medicine.medical_treatment, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], ARDS reassessment, ARDS Survival, Berlin criteria ARDS, Persisting ARDS, Critical Care and Intensive Care Medicine, assisted ventilation, 0302 clinical medicine, Risk Factors, 030212 general & internal medicine, risk factor, Adult, Tidal volume, comparative study, education.field_of_study, Respiratory Distress Syndrome, Mortality rate, Remission Induction, tidal volume, artificial ventilation, clinical trial, immunosuppressive treatment, adult respiratory distress syndrome, Middle Aged, Monte Carlo method, medicine.anatomical_structure, classification, positive end expiratory pressure, Cardiology, Disease Progression, SOFA score, disease severity, Female, Adult, medicine.medical_specialty, Population, disease classification, Article, NO, 03 medical and health sciences, remission, length of stay, Anesthesiology, Internal medicine, medicine, pneumonia, Sequential Organ Failure Assessment Score, Humans, human, education, Aged, Mechanical ventilation, hospital mortality, Lung, business.industry, Risk Factor, disease association, Respiratory Distress Syndrome, Adult, medicine.disease, major clinical study, mortality, Respiration, Artificial, breathing rate, 030228 respiratory system, disease exacerbation, business
Abstract: Purpose: To evaluate patients with resolved versus confirmed ARDS, identify subgroups with substantial mortality risk, and to determine the utility of day 2 ARDS reclassification. Methods: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus confirmed ARDS after 24 h. Secondary objectives included identifying factors associated with ARDS persistence and mortality, and the utility of day 2 ARDS reclassification. Results: Of 2377 patients fulfilling the ARDS definition on the first day of ARDS (day 1) and receiving invasive mechanical ventilation, 503 (24%) no longer fulfilled the ARDS definition the next day, 52% of whom initially had moderate or severe ARDS. Higher tidal volume on day 1 of ARDS was associated with confirmed ARDS [OR 1.07 (CI 1.01–1.13), P = 0.035]. Hospital mortality was 38% overall, ranging from 31% in resolved ARDS to 41% in confirmed ARDS, and 57% in confirmed severe ARDS at day 2. In both resolved and confirmed ARDS, age, non-respiratory SOFA score, lower PEEP and P/F ratio, higher peak pressure and respiratory rate were each associated with mortality. In confirmed ARDS, pH and the presence of immunosuppression or neoplasm were also associated with mortality. The increase in area under the receiver operating curve for ARDS reclassification on day 2 was marginal. Conclusions: ARDS, whether resolved or confirmed at day 2, has a high mortality rate. ARDS reclassification at day 2 has limited predictive value for mortality. The substantial mortality risk in severe confirmed ARDS suggests that complex interventions might best be tested in this population. Trial Registration: ClinicalTrials.gov NCT02010073. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature and ESICM.
Published: 2018

45. Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial

Author: Yi-Long Wu, Ying Cheng, Jianying Zhou, Shun Lu, Yiping Zhang, Jun Zhao, Dong-Wan Kim, Ross Andrew Soo, Sang-We Kim, Hongming Pan, Yuh-Min Chen, Chih-Feng Chian, Xiaoqing Liu, Daniel Shao Weng Tan, Rolf Bruns, Josef Straub, Andreas Johne, Jürgen Scheele, Keunchil Park, James Chih-Hsin Yang, Zhe Liu, Xi Chen, Mengzhao Wang, Shiying Yu, Helong Zhang, Jian Fang, Wei Li, Chih-Hsin Yang, Gee-Chen Chang, Te-Chun Hsia, Cheng-Ta Yang, Chin-Chou Wang, Byoung Chul Cho, Ki Hyeong Lee, Young-Chul Kim, Ho Jung An, In Sook Woo, Jae Yong Cho, Sang Won Shin, Jong-Seok Lee, Joo-Hang Kim, Seung Soo Yoo, Terufumi Kato, Naofumi Shinagawa, Shao Weng Daniel Tan, Lynette Si-Mien Ngo, Kananathan Ratnavelu, Azura Rozila Ahmad, Chong Kin Liam, Filippo de Marinis, Pierfrancesco Tassone, Amelia Insa Molla, Antonio Calles Blanco, Martin Emilio Lazaro Quintela, Enriqueta Felip Font, Anne-Marie Dingemans, and Lynne Bui
Subjects: Male, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Risk Assessment, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Gefitinib, Piperidines, Carcinoma, Non-Small-Cell Lung, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Clinical endpoint, Humans, media_common.cataloged_instance, 030212 general & internal medicine, European union, Lung cancer, Aged, Proportional Hazards Models, EGFR inhibitors, media_common, Chemotherapy, business.industry, Hazard ratio, Middle Aged, Proto-Oncogene Proteins c-met, Prognosis, medicine.disease, Survival Analysis, ErbB Receptors, Gene Expression Regulation, Neoplastic, Pyridazines, Pyrimidines, Treatment Outcome, 030228 respiratory system, Drug Resistance, Neoplasm, Mutation, Absolute neutrophil count, Female, business, medicine.drug
Abstract: Summary Background We evaluated the efficacy and safety of tepotinib, a potent and highly selective oral MET inhibitor, plus gefitinib in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) with MET overexpression (immunohistochemistry [IHC]2+ or IHC3+) or MET amplification having acquired resistance to EGFR inhibition. Methods In this open-label, phase 1b/2, multicentre, randomised trial (the INSIGHT study), we enrolled adult patients (≥18 years) with advanced or metastatic NSCLC, and Eastern Cooperative Oncology Group performance status of 0 or 1, from academic medical centres and community clinics in six Asian countries. In phase 1b, patients received oral tepotinib 300 mg or 500 mg plus gefitinib 250 mg once daily. In phase 2, patients with EGFR-mutant, T790M-negative NSCLC MET overexpression or MET amplification were randomly assigned (initially in a 1:1 ratio and then 2:1 following a protocol amendment) to tepotinib plus gefitinib at the recommended phase 2 dose or to standard platinum doublet chemotherapy. Randomisation was done centrally via an interactive voice-response system. The primary endpoint was investigator-assessed progression-free survival (PFS). Secondary endpoints included overall survival (OS) and safety. Subgroup analyses were preplanned in patients with high MET overexpression (IHC3+) or MET amplification (mean gene copy number ≥5 or MET to centromere of chromosome 7 ratio ≥2). Efficacy and patient characteristics were assessed on an intention-to-treat basis and safety was assessed for all patients who received at least one dose of study medication. Low recruitment led to early termination of phase 2, so all analyses are considered to be exploratory. This study is registered with ClinicalTrials.gov , NCT01982955 , and the European Union Drug Regulating Authorities Clinical Trials Database, Eudra-CT 2016-001604-28. Findings From Dec 23, 2013, to May 25, 2017, 18 patients were enrolled in phase 1b (n=6 in the 300 mg tepotinib group; n=12 in the 500 mg tepotinib group) and 55 patients in phase 2 (n=31 in the tepotinib plus gefitinib group; n=24 in the chemotherapy group). No dose-limiting toxicities were observed in phase 1b, so tepotinib 500 mg was used as the recommended phase 2 dose. In phase 2, survival outcomes were similar between groups: median PFS was 4·9 months in the tepotinib plus gefitinib group (90% CI 3·9–6·9) versus 4·4 months in the chemotherapy group (90% CI 4·2–6·8; hazard ratio [HR] 0·67, 90% CI 0·35–1·28). Median OS was 17·3 months in the tepotinib plus gefitinib group (12·1–37·3) versus 18·7 months in the chemotherapy group (15·9–20·7; HR 0·69, 0·34–1·41). PFS and OS were longer with tepotinib plus gefitinib than with chemotherapy in patients with high (IHC3+) MET overexpression (n=34; median PFS 8·3 months [4·1–16·6] vs 4·4 months [4·1–6·8]; HR 0·35, 0·17–0·74; median OS 37·3 months [90% CI 24·2–37·3] vs 17·9 months [12·0–20·7]; HR 0·33, 0·14–0·76) or MET amplification (n=19; median PFS 16·6 months [8·3–not estimable] vs 4·2 months [1·4–7·0]; HR 0·13, 0·04–0·43; median OS 37·3 months [90% CI not estimable] vs 13·1 months [3·25–not estimable]; HR 0·08, 0·01–0·51). The most frequent treatment-related grade 3 or worse adverse events were increased amylase (5 [16%] of 31 patients) and lipase (4 [13%]) concentrations in the tepotinib plus gefitinib group and anaemia (7 [30%] of 23 patients) and decreased neutrophil count (3 [13%]) in the chemotherapy group. Interpretation Despite early study termination, in a preplanned subgroup analysis, our findings suggest improved anti activity for tepotinib plus gefitinib compared with standard chemotherapy in patients with EGFR-mutant NSCLC and MET amplification, warranting further exploration. Funding Merck KGaA.
Published: 2020
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46. Between fear and courage: Attitudes, beliefs, and behavior of liver transplantation recipients and waiting list candidates during the COVID-19 pandemic

Author: Tony Bruns, Andreas Stallmach, Stefanie Albers, Falk Rauchfuss, Christian Trautwein, Utz Settmacher, and Philipp A. Reuken
Subjects: Male, medicine.medical_specialty, Waiting Lists, medicine.medical_treatment, Comorbidity, Liver transplantation, Chronic liver disease, Liver disease, Ambulatory care, Risk Factors, Germany, Internal medicine, medicine, Humans, Immunology and Allergy, Pharmacology (medical), Aged, Retrospective Studies, Transplantation, SARS-CoV-2, business.industry, COVID-19, Immunosuppression, Retrospective cohort study, Original Articles, Fear, Middle Aged, medicine.disease, Courage, Transplant Recipients, Liver Transplantation, Attitude, Original Article, Female, business, Liver Failure, Follow-Up Studies
Abstract: Patients with chronic liver disease and patients after solid organ transplantation (SOT) are vulnerable to severe coronavirus disease 2019 (COVID-19). We evaluated fears, attitudes, and opinions associated with COVID-19 in 365 SOT recipients (95% liver, 5% pancreas/kidney), 112 SOT candidates, and 394 immediate household contacts in 2 German transplant centers. Seven (1.5%) patients and 10 (2.5%) controls had contact with confirmed COVID-19 cases. Fear of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was expressed by 65% of SOT recipients and by 55% of SOT candidates. SOT recipients had higher levels of fear of infection and more often wore personal protective gear than household controls. Female sex, steroid treatment, and using the local newspaper as a primary source of information were independently associated with expressed fear of infection in SOT recipients. Younger age and more recent transplantation correlated with concerns about severe COVID-19 expressed by patients and with concerns about worse medical care expressed by household controls. One third of the patients expressed fear that immunosuppression could worsen COVID-19 but only 15% used the transplantation center as a source of information. These data show that fears associated with the SARS-CoV-2 pandemic are frequently expressed but measures to prevent infection are regularly followed by patients before and after SOT.
Published: 2020
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47. Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma

Author: Martin Thelen, Dirk Waldschmidt, Thomas Zander, Alexander Quaas, Michael von Bergwelt-Baildon, Maria Garcia-Marquez, Katharina Leuchte, Christiane Bruns, Uta Drebber, E Staib, Philipp Gödel, Dirk L. Stippel, Axel Lechner, Roger Wahba, Christian Wybranski, Kerstin Wennhold, Hans A. Schlößer, Peter Zentis, and Rabi R Datta
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, medicine.medical_treatment, T cell, Immunology, Abscopal effect, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Internal medicine, medicine, Humans, Immunology and Allergy, Prospective Studies, Antigens, Microwaves, Aged, 030304 developmental biology, Aged, 80 and over, 0303 health sciences, business.industry, Liver Neoplasms, Microwave ablation, Immunity, Immunotherapy, Middle Aged, Prognosis, medicine.disease, Survival Rate, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Catheter Ablation, Immunogenic cell death, Female, Original Article, business, Follow-Up Studies
Abstract: Thermal ablative therapies are standard treatments for localized hepatocellular carcinoma (HCC). In addition to local tumor destruction, ablation leads to abscopal effects in distant lesions most likely mediated by an anti-tumor immune response. Although microwave ablation (MWA) is increasingly substituting other ablative techniques, its systemic immunostimulatory effects are poorly studied. We analyzed tumor-specific immune responses in peripheral blood of HCC patients after thermal ablation with regard to T cell responses and disease outcome. While comprehensive flow cytometric analyses in sequential samples of a prospective patient cohort (n = 23) demonstrated only moderate effects of MWA on circulating immune cell subsets, fluorospot analyses of specific T cell responses against seven tumor-associated antigens (TTAs) revealed de-novo or enhanced tumor-specific immune responses in 30% of patients. This anti-tumor immune response was related to tumor control as Interferon-y and Interleukin-5 T cell responses against TAAs were more frequent in patients with a long-time remission (> 1 year) after MWA (7/16) compared to patients suffering from an early relapse (0/13 patients) and presence of tumor-specific T cell response (IFN-y and/or IL-5) was associated to longer progression-free survival (27.5 vs. 10.0 months). Digital image analysis of immunohistochemically stained archival HCC samples (n = 18) of patients receiving combined MWA and resection revealed a superior disease-free survival of patients with high T cell abundance at the time of thermal ablation (37.4 vs. 13.1 months). Our data demonstrates remarkable immune-related effects of MWA in HCC patients and provides additional evidence for a combination of local ablation and immunotherapy in this challenging disease. Electronic supplementary material The online version of this article (10.1007/s00262-020-02734-1) contains supplementary material, which is available to authorized users.
Published: 2020
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48. Chirurgische Therapie des Ösophaguskarzinoms – Qualitätsindikatoren für Diagnostik und Therapie

Author: Qualitätskommission der Deutschen Gesellschaft für Allgemein und Viszeralchirurgie, Heinz J Buhr, Dietmar Lorenz, Christiane Bruns, Michael Ghadimi, Ines Gockel, Patrick Sven Plum, and Jens Hoeppner
Subjects: Gynecology, medicine.medical_specialty, business.industry, Esophageal cancer, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Transplant surgery, Cardiothoracic surgery, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, Surgery, Surgical treatment, business, Abdominal surgery
Abstract: Zusammenfassung Hintergrund Im Rahmen der Qualitätsinitiative der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV) wurde eine Übersichtsarbeit auf der Grundlage einer systematischen Literatursuche verfasst und Empfehlungen für die aktuelle Diagnostik und Therapie des Ösophaguskarzinoms erarbeitet. Methoden Die systematische Literatursuche erfolgte gemäß den PRISMA-Kriterien unter Verwendung der MEDLINE-Datenbank und wurde im März 2019 durchgeführt. Die Empfehlungen wurden auf der Grundlage von Abstimmungen in der DGAV formuliert. Ergebnisse und Schlussfolgerung Operationen unterhalb der derzeit gültigen Mindestmenge sollten nicht mehr durchgeführt werden. Es spricht vieles dafür, die Mindestmenge in Deutschland auf ≥20 Resektionen/Jahr/Krankenhaus anzuheben, um die Qualität flächendeckend zu verbessern. Prähabilitationsprogramme mit Ausdauer‑, Kraft- und intensivem Atemtraining und Ernährungstherapie verbessern das Patientenoutcome. Die aktuelle Therapie des Ösophaguskarzinoms erfolgt stadienabhängig und umfasst die endoskopische Resektion bei (sub‑)mukosalen Low-risk-Tumoren (T1m1–3 bzw. T1sm1 „low risk“), die primäre Ösophagektomie bei submukosalen High-risk-Tumoren (T1a), Submukosakarzinomen (T1sm2–3) und T2N0-Tumoren, die multimodale Therapie mittels neoadjuvanter Radiochemotherapie bzw. perioperativer Chemotherapie und Operation bei fortgeschrittenen Befunden. Die Ösophagektomie wird gegenwärtig einzeitig als sog. Hybridverfahren (Laparoskopie und muskelschonende Thorakotomie) oder als total minimal-invasive Operation (Laparoskopie und Thorakoskopie) durchgeführt.
Published: 2020
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49. Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling

Author: Nina N. Seel, Verena Liu, Mario H. Müller, Ioannis Pozios, Martin E. Kreis, Christiane J. Bruns, Lisa Hartmann, Nina A. Hering, Hendrik Seeliger, Peter Camaj, and Lucas D. Lee
Subjects: Male, Cancer Research, Small interfering RNA, Time Factors, endocrine system diseases, Estrogen receptor, Stat3 Signaling Pathway, STAT3, chemistry.chemical_compound, Cytokine Receptor gp130, ERβ, Neoplasm Metastasis, Gene knockdown, biology, General Medicine, Oncology, Molecular Medicine, Original Article, Growth inhibition, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, medicine.drug, Signal Transduction, STAT3 Transcription Factor, Mice, Nude, Adenocarcinoma, gp130, Pancreatic cancer, Cell Line, Tumor, medicine, Animals, Estrogen Receptor beta, Humans, Raloxifene, Cell Proliferation, IL-6, Interleukin-6, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, SERM, Pancreatic Neoplasms, chemistry, Raloxifene Hydrochloride, Cancer research, biology.protein
Abstract: Purpose Currently, the exact role of estrogen receptor (ER) signaling in pancreatic cancer is unknown. Recently, we showed that expression of phosphorylated ERβ correlates with a poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here, we hypothesized that raloxifene, a FDA-approved selective ER modulator (SERM), may suppress PDAC tumor growth by interfering with ERβ signaling. To test this hypothesis, we studied the impact of raloxifene on interleukin-6/glycoprotein-130/signal transducer and activator of transcription-3 (IL-6/gp130/STAT3) signaling. Methods Human PDAC cell lines were exposed to raloxifene after which growth inhibition was assessed using a BrdU assay. ER knockdown was performed using siRNAs specific for ERα and ERβ. The effects of raloxifene on IL-6 expression and STAT3 phosphorylation in PDAC cells were assessed by ELISA and Western blotting, respectively. In addition, raloxifene was administered to an orthotopic PDAC tumor xenograft mouse model, after which tumor growth was monitored and immunohistochemistry was performed. Results Raloxifene inhibited the in vitro growth of PDAC cells, and this effect was reversed by siRNA-mediated knockdown of ERβ, but not of ERα, indicating ER isotype-specific signaling. We also found that treatment with raloxifene inhibited the release of IL-6 and suppressed the phosphorylation of STAT3Y705 in PDAC cells. In vivo, we found that orthotopic PDAC tumor growth, lymph node and liver metastases as well as Ki-67 expression were reduced in mice treated with raloxifene. Conclusions Inhibition of ERβ and the IL-6/gp130/STAT3 signaling pathway by raloxifene leads to potent reduction of PDAC growth in vitro and in vivo. Our results suggest that ERβ signaling and IL-6/gp130 interaction may serve as promising drug targets for pancreatic cancer and that raloxifene may serve as an attractive therapeutic option for PDAC patients expressing the ERβ isotype.
Published: 2020

50. Characteristics and Outcomes of Drainage Versus Surgery First in Severe Pancreatitis

Author: Kevin Kim, Brandon R. Bruns, Jose J. Diaz, Melike Harfouche, and Jaclyn Clark
Subjects: Male, medicine.medical_specialty, Percutaneous, business.industry, Incidence, General Medicine, Middle Aged, medicine.disease, Severity of Illness Index, United States, Surgery, Pancreatectomy, Postoperative Complications, Pancreatitis, Drainage, Humans, Medicine, Female, Registries, business, Retrospective Studies
Abstract: Background Percutaneous drainage as the initial procedure for severe pancreatitis (SP) may not always be optimal. Our aim was to identify the characteristics of patients who failed percutaneous drainage and compare their outcomes with patients who underwent surgical intervention as the initial approach. Methods A retrospective review of a prospectively collected emergency general surgery registry of patients admitted to a tertiary-care, academic center with the diagnosis of SP who underwent an intervention was performed (2010-2018). Patients were divided into successful drainage (SD), drainage failure (DF), and surgery first (SF) groups. DF was defined as the need for surgical intervention. Results The study included 129 patients. Fifty (38.8%) patients underwent SF as their initial management modality. Among 79 patients who underwent drainage, 34 (43.0%) were in the DF group and progressed to surgical intervention. Within that group, 19 (55.9%) underwent open necrosectomy. The DF group was more likely to have lower rates of peripancreatic fluid collections, a higher rate of necrotizing pancreatitis, and a higher Acute Physiology and Chronic Health Evaluation (APACHE) II score when compared with the DS group. Mortality was higher in the DF and SF groups, and total length of stay and ICU length of stay were highest in the DF group. Discussion Patients who experience failure of drainage for SP have high morbidity and mortality rates and fare worse overall than patients who undergo surgery as the primary intervention. Patients with necrotizing pancreatitis and a higher APACHE II score might warrant surgical intervention over a drainage-first approach.
Published: 2020
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