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1. PICO Questions and DELPHI Methodology for the Management of Venous Thromboembolism Associated with COVID-19

Author

Riera-Mestre, Antoni, Jara-Palomares, Luis, Lecumberri, Ramón, Trujillo-Santos, Javier, Grau, Enric, Blanco-Molina, Angeles, Carbonell, Ana Piera, Jiménez, Sonia, Vargas, Manuel Frías, Fuset, Mari, Bellmunt-Montoya, Sergi, Monreal, Manuel, Jiménez, David, Project, on behalf of the COVILAX, Institut Català de la Salut, [Riera-Mestre A] Internal Medicine Department, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. [Jara-Palomares L] Medical-Surgical Unit for Respiratory Diseases, Virgen del Rocío University Hospital, Sevilla, Spain. Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Lecumberri R] Hematology Department, Clínica Universidad de Navarra, Pamplona, Spain. Center for Biomedical Research Network on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. [Trujillo-Santos J] Internal Medicine Department, Hospital General Universitario Santa Lucía, Cartagena, Spain. Faculty of Health Sciences, Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain. [Grau E] Hematology Department, Lluis Alcanyis de Xativa Hospital, Valencia, Spain. [Blanco-Molina A] Internal Medicine Unit, Hospital Universitario Reina Sofía, Córdoba, Spain. [Bellmunt-Montoya S] Servei de Angiologia, Cirurgia Vascular i Endovascular, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Cirurgia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
pulmonary embolism, Delphi Technique, Coronaviruses, Deep vein, Delphi method, coronavirus, law.invention, law, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Medicine, Trombosi, enfermedades cardiovasculares::enfermedades vasculares::embolia y trombosis::tromboembolia::tromboembolia venosa [ENFERMEDADES], anticoagulation, COVID-19 (Malaltia) - Complicacions, Embòlia pulmonar, Cardiovascular Diseases::Vascular Diseases::Embolism and Thrombosis::Thromboembolism::Venous Thromboembolism [DISEASES], Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Venous Thromboembolism, Medicina clínica - Presa de decisions, Intensive care unit, Thrombosis, QR1-502, Pulmonary embolism, Ciencias de la información::análisis de sistemas::técnica Delfos [CIENCIA DE LA INFORMACIÓN], Infectious Diseases, medicine.anatomical_structure, Information Science::Systems Analysis::Delphi Technique [INFORMATION SCIENCE], medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.drug_class, Low molecular weight heparin, Microbiology, Article, deep vein thrombosis, Virology, Humans, Intensive care medicine, Tromboembolisme, Duration of Therapy, business.industry, fungi, Anticoagulants, COVID-19, Heparin, Low-Molecular-Weight, medicine.disease, Coronavirus, Embolism, business, venous thromboembolic disease
Abstract

Patients with coronavirus disease 2019 (COVID-19) have a higher risk of venous thromboembolic disease (VTE) than patients with other infectious or inflammatory diseases, both as macrothrombosis (pulmonar embolism and deep vein thrombosis) or microthrombosis. However, the use of anticoagulation in this scenario remains controversial. This is a project that used DELPHI methodology to answer PICO questions related to anticoagulation in patients with COVID-19. The objective was to reach a consensus among multidisciplinary VTE experts providing answers to those PICO questions. Seven PICO questions regarding patients with COVID-19 responded with a broad consensus: 1. It is recommended to avoid pharmacological thromboprophylaxis in most COVID-19 patients not requiring hospital admission, 2. In most hospitalized patients for COVID-19 who are receiving oral anticoagulants before admission, it is recommended to replace them by low molecular weight heparin (LMWH) at therapeutic doses, 3. Thromboprophylaxis with LMWH at standard doses is suggested for COVID-19 patients admitted to a conventional hospital ward, 4. Standard-doses thromboprophylaxis with LMWH is recommended for COVID-19 patients requiring admission to Intensive Care Unit, 5. It is recommended not to determine D-Dimer levels routinely in COVID-19 hospitalized patients to select those in whom VTE should be suspected, or as a part of the diagnostic algorithm to rule out or confirm a VTE event, 6. It is recommended to discontinue pharmacological thromboprophylaxis at discharge in most patients hospitalized for COVID-19, 7. It is recommended to withdraw anticoagulant treatment after 3 months in most patients with a VTE event associated with COVID-19. The combination of PICO questions and DELPHI methodology provides a consensus on different recommendations for anticoagulation management in patients with COVID-19.

Published
2021
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2. Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

Author

Jara-Palomares, Luis, Alfonso, Maria, Maestre, Ana, Jimenez, David, Garcia-Bragado, Fernando, Font, Carme, Lopez Reyes, Raquel, Hernandez Blasco, Luis, Vidal, Gemma, Otero, Remedios, Monreal, Manuel, Adarraga, Ma Dolores, Angel Aibar, Miguel, Aibar, Jesus, Amado, Cristina, Ignacio Arcelus, Juan, Ballaz, Aitor, Barba, Raquel, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Blanco-Molina, Angeles, Maria Camon, Ana, Canas, Inmaculada, Carrasco, Cristina, Castro, Joaquin, de Ancos, Cristina, Del Toro, Jorge, Demelo, Pablo, Antonio Diaz-Peromingo, Jose, Diaz-Simon, Raquel, Falga, Conxita, Isabel Farfan, Ana, Fernandez-Capitan, Carmen, Del Carmen Fernandez-Criado, Maria, Fernandez-Nunez, Sandra, Fidalgo, Angeles, Font, Llorenc, Angelina Garcia, Maria, Garcia-Morillo, Marcial, Garcia-Raso, Aranzzu, Gavin-Sebastian, Olga, del Carmen Gayol, Maria, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grau, Enric, Gutierrez, Javier, Gutierrez-Gonzalez, Sara, Iglesias, Marina, Jaras, Ma Jesus, Jou, Ines, Dolores Joya, Maria, Lalueza, Antonio, Lima, Jorge, Llamas, Pilar, Luis Lobo, Jose, Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Jose Lopez-Nunez, Juan, Bosco Lopez-Saez, Juan, Alejandro Lorente, Manuel, Lorenzo, Alicia, Loring, Monica, Madridano, Olga, Javier Marchena, Pablo, Miguel Martin, Javier, Mellado, Meritxell, del Valle Morales, Ma, Luisa Nieto, Maria, Antonio Nieto, Jose, Jesus Nunez, Manuel, Carmen Olivares, Maria, Maria Pedrajas, Jose, Pellejero, Galadriel, Prez-Rus, Gloria, Peris, Ma Luisa, Antonio Porras, Jose, Rivas, Agustina, Angeles Rodriguez-Davila, Ma, Adela Rodriguez-Hernandez, A, Rubio, Carmen Ma, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Carles Sahuquillo, Joan, Salazar, Vladimir, Samperiz, Angel, Sanchez Munoz-Torrero, Juan Francisco, Sancho, Teresa, Soler, Silvia, Maria Surinach, Jose, Tapia, Elena, Tolosa, Caries, Isabel Torres, Maria, Trujillo-Santos, Javier, Uresandi, Fernando, Valle, Reina, Villares, Paula, Gutierrez, Paula, Javier Vazquez, Fernando, Vilaseca, Alicia, Vanassche, Thomas, Vandenbriele, Christophe, Verhamme, Peter, Hirmerova, Jana, Maly, Radovan, Celis, Gregory, del Pozo, Gustavo, Salgado, Estuardo, Benzidia, Ilham, Bertoletti, Laurent, Bura-Riviere, Alessandra, Debourdeau, Philippe, Farge-Bancel, Dominique, Hij, Adrian, Mahe, Isabelle, Moustafa, Fares, Schellong, Sebastian, Braester, Andrei, Brenner, Benjamin, Tzoran, Inna, Sharif-Kashani, Babak, Barillari, Giovanni, Bilora, Franca, Bortoluzzi, Cristiano, Brandolin, Barbara, Bucherini, Eugenio, Ciammaichella, Maurizio, Dentali, Francesco, Di Micco, Pierpaolo, Maida, Rosa, Mastroiacovo, Daniela, Mumoli, Nicola, Pace, Federica, Parisi, Roberto, Pesavento, Raffaelle, Prandoni, Paolo, Quintavalla, Roberto, Rocci, Anna, Romualdi, Roberta, Sinicalchi, Carmine, Tufano, Antonella, Visona, Adriana, Hong, Ngoc Vo, Zalunardo, Beniamino, Gibietis, Valdis, Kigitovica, Dana, Skride, Andris, Bosevski, Marijan, Bounameaux, Henri, Mazzolai, Lucia, Caprini, Joseph A, Hanh, My Bui, Khanh, Quoc Pham, Reis, Abilio, UCH. Departamento de Medicina (Extinguido), Producción Científica UCH 2019, UCH. Departamento de Medicina y Cirugía, Sanofi España, Bayer, Sociedad Española de Neumología y Cirugía Torácica, Jara-Palomares, L., Alfonso, M., Maestre, A., Jimenez, D., Garcia-Bragado, F., Font, C., Reyes, R. L., Blasco, L. H., Vidal, G., Otero, R., Monreal, M., Adarraga, M. ªD., Aibar, M. A., Aibar, J., Amado, C., Arcelus, J. I., Ballaz, A., Barba, R., Barron, M., Barron-Andres, B., Bascunana, J., Blanco-Molina, A., Camon, A. M., Canas, I., Carrasco, C., Castro, J., de Ancos, C., Del Toro, J., Demelo, P., Diaz-Peromingo, J. A., Diaz-Simon, R., Falga, C., Farfan, A. I., Fernandez-Capitan, C., del Carmen Fernandez-Criado, M., Fernandez-Nunez, S., Fidalgo, A., Font, L., Garcia, M. A., Garcia-Morillo, M., Garcia-Raso, A., Gavin-Sebastian, O., del Carmen Gayol, M., Gil-Diaz, A., Gomez, V., Gomez-Cuervo, C., Gonzalez-Martinez, J., Grau, E., Gutierrez, J., Gutierrez-Gonzalez, S., Iglesias, M., Jaras, M. ªJ., Jou, I., Joya, M. D., Lalueza, A., Lima, J., Llamas, P., Lobo, J. L., Lopez-Jimenez, L., Lopez-Miguel, P., Lopez-Nunez, J. J., Lopez-Saez, J. B., Lorente, M. A., Lorenzo, A., Loring, M., Madridano, O., Marchena, P. J., Martin, J. M., Mellado, M., Morales, M. ªV., Nieto, M. L., Nieto, J. A., Nunez, M. J., Olivares, M. C., Pedrajas, J. M., Pellejero, G., Perez-Rus, G., Peris, M. ªL., Porras, J. A., Rivas, A., Rodriguez-Davila, M. ªA., Adela Rodriguez-Hernandez, A., Rubio, C. M., Ruiz-Artacho, P., Ruiz-Ruiz, J., Ruiz-Sada, P., Sahuquillo, J. C., Salazar, V., Samperiz, A., Munoz-Torrero, J. F. S., Sancho, T., Soler, S., Surinach, J. M., Tapia, E., Tolosa, C., Torres, M. I., Trujillo-Santos, J., Uresandi, F., Valle, R., Villares, P., Gutierrez, P., Vazquez, F. J., Vilaseca, A., Vanassche, T., Vandenbriele, C., Verhamme, P., Hirmerova, J., Maly, R., Celis, G., del Pozo, G., Salgado, E., Benzidia, I., Bertoletti, L., Bura-Riviere, A., Debourdeau, P., Farge-Bancel, D., Hij, A., Mahe, I., Moustafa, F., Schellong, S., Braester, A., Brenner, B., Tzoran, I., Sharif-Kashani, B., Barillari, G., Bilora, F., Bortoluzzi, C., Brandolin, B., Bucherini, E., Ciammaichella, M., Dentali, F., Di Micco, P., Maida, R., Mastroiacovo, D., Mumoli, N., Pace, F., Parisi, R., Pesavento, R., Prandoni, P., Quintavalla, R., Rocci, A., Romualdi, R., Sinicalchi, C., Tufano, A., Visona, A., Hong, N. V., Zalunardo, B., Gibietis, V., Kigitovica, D., Skride, A., Bosevski, M., Bounameaux, H., Mazzolai, L., Caprini, J. A., Bui, H. M., Pham, K. Q., and Reis, A.

Subjects
PREDICTION, Embolism, Aparato circulatorio - Enfermedades - Pronóstico, Cardiovascular system - Diseases - Prognosis, lcsh:Medicine, 030204 cardiovascular system & hematology, 0302 clinical medicine, Retrospective Studie, Risk Factors, 030212 general & internal medicine, lcsh:Science, INDEX, education.field_of_study, Multidisciplinary, Middle Aged, Prognosis, Predictive value, Pulmonary embolism, Multidisciplinary Sciences, DERIVATION, Science & Technology - Other Topics, Major bleeding, Human, medicine.medical_specialty, ANTITHROMBOTIC THERAPY, Disease-free survival, Prognosi, Population, DIAGNOSIS, VALIDATION, Article, 03 medical and health sciences, STRATIFICATION, Thromboembolism, Internal medicine, medicine, Humans, In patient, education, Retrospective Studies, OLDER, VENOUS THROMBOEMBOLISM, Science & Technology, business.industry, Risk Factor, lcsh:R, CLINICAL PRESENTATION, Retrospective cohort study, medicine.disease, Embolia pulmonar - Pronóstico, Shock index, Pulmonary embolism - Prognosis, Spain, lcsh:Q, business, Pulmonary Embolism
Abstract

The RIETE investigators., In young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm, PREP, shock index and RIETE) in patients aged, This study received funding: SEPAR (1/2016) grupo GeCIR. We express our gratitude to Sanofi Spain for supporting this Registry with an unrestricted educational grant. We also wish to thank Bayer Pharma AG for supporting this Registry. Bayer Pharma AG’s support was limited to the part of RIETE outside Spain, which accounts for a 25.20% of the total patients included in the RIETE Registry.

Published
2019

3. Prediction of early mortality in patients with cancer-associated thrombosis in the rIete Database

Author

Fuentes, Harry E., Tafur, Alfonso J., Caprini, Joseph A., Alatri, Adriano, Trujillo-santos, Javier, Farge-bancel, Dominique, Rosa, Vladimir, Font, Llorenc, Vilaseca, Alicia, Monreal, Manuel, Adarraga, Maria D., Aibar, Miguel A., Aibar, Jesus, Amado, Cristina, Aranda, Carlos, Arcelus Juan, I, Ballaz, Aitor, Barba, Raquel, Barillari, Giovanni, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Benzidia, Ilham, Bertoletti, Laurent, Blanco-Molina, Angeles, Bilora, Franca, Bortoluzzi, Cristiano, Bosevski, Marijan, Bounameaux, Henri, Braester, Andrei, Brandolin, Barbara, Brenner, Benjamin, Bucherini, Eugenio, Hanh My Bui, Bura-Riviere, Alessandra, Camon, Ana M., Carrasco, Cristina, Castro, Joaquin, Cesta, Alisia, Ciammaichella, Maurizio, Cruz, Javier A., de Ancos, Cristina, del Toro, Jorge, Demelo, Pablo, Dentali, Francesco, del Carmen Diaz-pedroche, Maria, Diaz-Peromingo, Jose A., Di Micco, Pierpaolo, Di Pangrazio, Marco, Ellis, Martin, Encabo, Marta, Falga, Conxita, Falvo, Nicolas, Farfan Ana, Fernandez-Capitan, Carmen, Angeles Fidalgo, Maria, Font, Carme, Fresa, Marco, Furest, Ildefonso, Garcia, Maria A., Garcia-Braoado, Ferran, Garcia-Morillo, Marcia, Garcia-Raso, Aranzazu, Gavin, Olga, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grandone, Elvira, Grau, Enric, Guijarro, Ricardo, Gutierrez, Javier, Gutierrez, Paula, Hernandez-Blasco, Luis, Hu, Adrian, Hirmerova, Jana, Imbalzano, Egidio, Jara-Palomares, Luis, Jaras, Maria J., Jimenez, David, Jou, Ines, Joya, Maria D., Krstevski, Gorjan, Lessiani, Gianfranco, Lima, Jorge, Llamas, Pilar, Lobo, Jose L., Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Lopez-Nunez, Juan J., Lopez-Reyes, Raquel, Lopez-Saez, Juan B., Lorente, Manuel A., Lorenzo, Alicia, Loring, Monica, Lumbierres, Marina, Mahe, Isabelle, Maida, Rosa, Maly, Radovan, Manrique-Abos, Isabel, Marchena, Pablo J., Martin-Fernandez, Miguel, Martin-Guerra, Javier M., Martin-Romero, Miguel, Mastroiacovo, Danicla, Mazzolai, Lucia, Mellado, Meritxell, Merah, Adel, del Valle Morales, Maria, Moustafa, Fares, Ney, Barbara, Nieto, Jose A., Nunez, Manuel J., del Carmen Olivares, Maria, Otalora, Sonia, Otero, Remedios, Pace, Federica, Parisi, Roberto, Pedrajas, Jose Maria, Pellejero, Galadriel, Perez-Ductor, Cristina, Perez-Jacoiste, Asuncion, Perez-Rus, Gloria, Peris, Maria L., Pesavento, Raffaele, Pesce, Maria L., Porras, Jose A., Prandoni, Paolo, Quinta-Valla, Roberto, Riesco, David, Rivas, Agustina, Rocci, Anna, Rodriguez-Davila, Maria A., Rodriguez-Hernandez, Adela, Rubio, Carmen M., Ruiz-Alcaraz, Sandra, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Ruiz-Torregrosa, Paloma, Sahuquillo, Joan C., Sala-Sainz, Carmen, Salgado, Estuardo, Samperiz, Angel, Sanchez-Munoz-Torrero, Juan F., Sancho, Teresa, Sanoja, Indra D., Siniscalchi, Carmine, Skride, Andris, Soler, Silvia, Sotgiu, Pietro, Soto, Maria J., Surinach, Jose M., Tiraferri, Eros, Tonello, Diego, Torres Maria, Tufano, Antonella, Tzoran, Inns, Uresandi, Fernando, Usandizaga, Esther, Valle, Reins, Vanassche, Thomas, Vandenbriele, Christophe, Vazquez, Fernando J., Verhamme, Peter, Villalobos, Aurora, Visona, Adriana, Ngoc Vo Hong, Yoo, Hugo H., Zdraveska, Marija, Fuentes, Harry E., Tafur, Alfonso J., Caprini, Joseph A., Alatri, Adriano, Trujillo-santos, Javier, Farge-bancel, Dominique, Rosa, Vladimir, Font, Llorenc, Vilaseca, Alicia, Monreal, Manuel, Adarraga, Maria D., Aibar, Miguel A., Aibar, Jesu, Amado, Cristina, Aranda, Carlo, Arcelus, Juan, I, Ballaz, Aitor, Barba, Raquel, Barillari, Giovanni, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Benzidia, Ilham, Bertoletti, Laurent, Blanco-Molina, Angele, Bilora, Franca, Bortoluzzi, Cristiano, Bosevski, Marijan, Bounameaux, Henri, Braester, Andrei, Brandolin, Barbara, Brenner, Benjamin, Bucherini, Eugenio, Hanh My, Bui, Bura-Riviere, Alessandra, Camon, Ana M., Carrasco, Cristina, Castro, Joaquin, Cesta, Alisia, Ciammaichella, Maurizio, Cruz, Javier A., de Ancos, Cristina, del Toro, Jorge, Demelo, Pablo, Dentali, Francesco, del Carmen Diaz-pedroche, Maria, Diaz-Peromingo, Jose A., Di Micco, Pierpaolo, Di Pangrazio, Marco, Ellis, Martin, Encabo, Marta, Falga, Conxita, Falvo, Nicola, Farfan, Ana, Fernandez-Capitan, Carmen, Angeles Fidalgo, Maria, Font, Carme, Fresa, Marco, Furest, Ildefonso, Garcia, Maria A., Garcia-Braoado, Ferran, Garcia-Morillo, Marcia, Garcia-Raso, Aranzazu, Gavin, Olga, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grandone, Elvira, Grau, Enric, Guijarro, Ricardo, Gutierrez, Javier, Gutierrez, Paula, Hernandez-Blasco, Lui, Hu, Adrian, Hirmerova, Jana, Imbalzano, Egidio, Jara-Palomares, Lui, Jaras, Maria J., Jimenez, David, Jou, Ine, Joya, Maria D., Krstevski, Gorjan, Lessiani, Gianfranco, Lima, Jorge, Llamas, Pilar, Lobo, Jose L., Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Lopez-Nunez, Juan J., Lopez-Reyes, Raquel, Lopez-Saez, Juan B., Lorente, Manuel A., Lorenzo, Alicia, Loring, Monica, Lumbierres, Marina, Mahe, Isabelle, Maida, Rosa, Maly, Radovan, Manrique-Abos, Isabel, Marchena, Pablo J., Martin-Fernandez, Miguel, Martin-Guerra, Javier M., Martin-Romero, Miguel, Mastroiacovo, Danicla, Mazzolai, Lucia, Mellado, Meritxell, Merah, Adel, del Valle Morales, Maria, Moustafa, Fare, Ney, Barbara, Nieto, Jose A., Nunez, Manuel J., del Carmen Olivares, Maria, Otalora, Sonia, Otero, Remedio, Pace, Federica, Parisi, Roberto, Pedrajas, Jose Maria, Pellejero, Galadriel, Perez-Ductor, Cristina, Perez-Jacoiste, Asuncion, Perez-Rus, Gloria, Peris, Maria L., Pesavento, Raffaele, Pesce, Maria L., Porras, Jose A., Prandoni, Paolo, Quinta-Valla, Roberto, Riesco, David, Rivas, Agustina, Rocci, Anna, Rodriguez-Davila, Maria A., Rodriguez-Hernandez, Adela, Rubio, Carmen M., Ruiz-Alcaraz, Sandra, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Ruiz-Torregrosa, Paloma, Sahuquillo, Joan C., Sala-Sainz, Carmen, Salgado, Estuardo, Samperiz, Angel, Sanchez-Munoz-Torrero, Juan F., Sancho, Teresa, Sanoja, Indra D., Siniscalchi, Carmine, Skride, Andri, Soler, Silvia, Sotgiu, Pietro, Soto, Maria J., Surinach, Jose M., Tiraferri, Ero, Tonello, Diego, Torres, Maria, Tufano, Antonella, Tzoran, Inn, Uresandi, Fernando, Usandizaga, Esther, Valle, Rein, Vanassche, Thoma, Vandenbriele, Christophe, Vazquez, Fernando J., Verhamme, Peter, Villalobos, Aurora, Visona, Adriana, Ngoc Vo, Hong, Yoo, Hugo H., and Zdraveska, Marija

Subjects
Adult, Male, Internationality, Adolescent, Population, 030204 cardiovascular system & hematology, 030230 surgery, computer.software_genre, Logistic regression, Risk Assessment, Cohort Studies, Young Adult, 03 medical and health sciences, Mortality, Neoplasms, Premature, Thrombosis, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Humans, Medicine, Registries, Child, education, Aged, education.field_of_study, Framingham Risk Score, Database, business.industry, Infant, Newborn, Infant, Venous Thromboembolism, Odds ratio, Middle Aged, medicine.disease, Pulmonary embolism, Logistic Models, Child, Preschool, Predictive value of tests, Multivariate Analysis, Female, Cardiology and Cardiovascular Medicine, Risk assessment, business, computer, Cohort study
Abstract

BACKGROUND: Proper risk stratification of patients for early mortality after cancer-associated thrombosis may lead to personalized anticoagulation protocols. Therefore, we aimed to derive and validate a scoring system to predict early mortality in this population. To this end, we selected patients with active cancer and thrombosis from the Computerized Registry of Patients with Venous Thromboembolism database. METHODS: The main outcome was all cause mortality within the month following a thrombotic event. We used a simple random selection to split are data in a derivation and a validation cohort. In the derivation cohort, we used recursive partitioning and binary logistic regression to identify groups at risk and to determine the likelihood of the primary outcome. The risk score was developed based on odds ratios from the final multivariate model, and then tested in the validation cohort. RESULTS: In 10,025 eligible patients, we identified 6 predictors of 30-day mortality: leukocytosis =11.5x109/L; platelet count =160x109/L, metastasis, recent immobility, initial presentation as pulmonary embolism and Body Mass Index

Published
2019

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