1. Breast cancer among Asian Indian and Pakistani Americans: A surveillance, epidemiology and end results‐based study
- Author
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Tina Dharamdasani, Elisa V. Bandera, Jaya M. Satagopan, Anita Y. Kinney, Antoinette M. Stroup, and Shridar Ganesan
- Subjects
Adult ,Cancer Research ,medicine.medical_specialty ,Receptor, ErbB-2 ,India ,Breast Neoplasms ,California ,White People ,Article ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Breast cancer ,Epidemiology ,medicine ,Surveillance, Epidemiology, and End Results ,Humans ,Pakistan ,Cumulative incidence ,Registries ,Poisson regression ,Stage (cooking) ,Mastectomy ,Progesterone ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Retrospective Studies ,Asian ,New Jersey ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Middle Aged ,medicine.disease ,United States ,Receptors, Estrogen ,Oncology ,030220 oncology & carcinogenesis ,symbols ,Regression Analysis ,Female ,business ,Demography - Abstract
Breast cancer incidence is increasing among Asian Indian and Pakistani women living in the United States. We examined the characteristics of breast cancer in Asian Indian and Pakistani American (AIPA) and non-Hispanic white (NHW) women using data from the surveillance, epidemiology and end results (SEER) program. Breast cancer incidence rates were estimated via segmented Poisson regression using data between 1990 and 2014 from SEER 9 registries, including New Jersey and California. Disease characteristics, treatment and survival information between 2000 and 2016 for 4900 AIPA and 482 250 NHW cases diagnosed after age 18 were obtained from SEER 18 registries and compared using descriptive analyses and multivariable competing risk proportional hazards regression. Breast cancer incidence was lower in AIPA than NHW women, increased with age and the rate of increase declined after age of 46 years. AIPA women were diagnosed at significantly younger age (mean (SD) = 54.5 (13.3) years) than NHW women (mean (SD) = 62 (14) years, P < .0001) and were more likely than NHW cases (P < .0001) to have regional or distant stage, higher grade, estrogen receptor-negative, progesterone receptor-negative, triple-negative or human epidermal growth factor receptor 2-enriched tumors, subcutaneous or total mastectomy, and lower cumulative incidence of death due to breast cancer (hazard ratio = 0.79, 95% CI: 0.72-0.86, P < .0001). AIPA had shorter median follow-up (52 months) than NHW cases (77 months). Breast cancer in AIPA women has unique characteristics that need to be further studied along with a comprehensive evaluation of their follow-up patterns.
- Published
- 2020