13 results on '"Andrea Urbina"'
Search Results
2. Histopathological findings of infections caused by canine distemper virus, Trypanosoma cruzi, and other parasites in two free-ranging White-nosed Coatis Nasua narica (Carnivora: Procyonidae) from Costa Rica
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Jorge Rojas-Jiménez, Silvia E. Acevedo-González, Andrea Urbina-Villalobos, Michael J. Yabsley, Juan A. Morales-Acuña, and Milena Argüello-Sáenz
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0106 biological sciences ,Myocarditis ,Opportunistic infection ,010607 zoology ,CDV ,Management, Monitoring, Policy and Law ,010603 evolutionary biology ,01 natural sciences ,Virus ,MYOCARDITS ,PARÁSITOS ,parasitic diseases ,medicine ,Trypanosoma cruzi ,Ecology, Evolution, Behavior and Systematics ,POLYPARASITSM ,Nature and Landscape Conservation ,biology ,Canine distemper ,Meningoencephalitis ,Procyonidae ,Nasua ,TRYPANOSOMA CRUZI ,medicine.disease ,biology.organism_classification ,Virology ,NASUA NARICA ,PCR ,Animal Science and Zoology ,ENFERMEDAD DE CHAGAS - Abstract
Canine distemper virus (CDV) causes systemic infections and immunosuppression in carnivores, which subsequently makes animals highly susceptible to opportunistic infections. Although Trypanosoma cruzi infects procyonids, chagasic myocarditis in Coatis has not been reported in Central America. The aim of this study was to report the histopathological findings caused by canine distemper virus, T. cruzi, and other parasites in two free-ranging White-nosed Coatis Nasua narica found dead in a national park on the Pacific coast of Costa Rica. Heart, lung, tongue, liver, brain and spleen samples were subjected to macroscopic and microscopic examination. A mononuclear meningoencephalitis associated with intra-nuclear eosinophilic inclusion bodies consistent with canine distemper virus was observed in nervous tissue. Myocarditis and associated nests of amastigotes of T. cruzi were observed during microscopic examination in cardiac tissue, and in muscle from the tongue of both animals. Molecular analysis confirmed T. cruzi in formalin-fixed paraffin embedded cardiac tissues. The myocardial damage caused by the opportunistic infection due to T. cruzi in these individuals could be the result of a severe compromised immunological status associated to the CDV infection, and subsequent opportunistic polyparasitism described herein. To the authors knowledge this is the first report of chagasic myocarditis in free-ranging coatis from Central America. El virus del moquillo canino (VDC) provoca infecciones sistémicas e inmunosupresión en los carnívoros, lo que posteriormente hace que los animales sean muy susceptibles a las infecciones oportunistas. Aunque Trypanosoma cruzi infecta a los procónidos, en Centroamérica no se ha informado de la existencia de una miocarditis chagásica en los coatis. El objetivo de este estudio fue reportar los hallazgos histopatológicos causados por el virus del moquillo canino, T. cruzi y otros parásitos en dos Coatis Nasua narica en libertad encontrados muertos en un parque nacional en la costa del Pacífico de Costa Rica. Se sometieron a examen macroscópico y microscópico muestras de corazón, pulmón, lengua, hígado, cerebro y bazo. En el tejido nervioso se observó una meningoencefalitis mononuclear asociada a cuerpos de inclusión eosinófilos intranucleares compatibles con el virus del moquillo canino. Durante el examen microscópico se observaron miocarditis y nidos asociados de amastigotes de T. cruzi en el tejido cardíaco y en el músculo de la lengua de ambos animales. El análisis molecular confirmó la presencia de T. cruzi en los tejidos cardíacos fijados en parafina. El daño miocárdico causado por la infección oportunista debida a T. cruzi en estos individuos podría ser el resultado de un estado inmunológico severamente comprometido asociado a la infección por CDV, y al posterior poliparasitismo oportunista aquí descrito. Hasta donde saben los autores, éste es el primer informe de miocarditis chagásica en coatíes en libertad de América Central. Universidad de Georgia, Estados Unidos. Universidad Nacional, Costa Rica. Universidad Nacional Autónoma de México, México. Escuela de Medicina Veterinaria
- Published
- 2021
3. Severity of airway obstruction in COPD: comparison of z-score-based categorization approaches against FEV1%
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Ana Cerezo Barqueros, Tania Álvaro de Castro, Tomás Ruiz Albi, Milko Daniel Terranova Ríos, Ana Gómez García, Andrea Crespo Sedano, Félix del Campo Matias, Daniel Álvarez González, Fernando Moreno Torrero, Carolina Andrea Urbina Carrera, and Jose Ignacio Santos Plaza
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COPD ,medicine.medical_specialty ,Categorization ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Standard score ,Airway obstruction ,business ,medicine.disease - Published
- 2020
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4. Influence of air pollution on hospital admissions in patients with COPD or asthma exacerbation
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Ana Gómez García, Raúl López Izquierdo, Félix del Campo Matias, Lucía Arroyo, Fernando Moreno Torrero, Milko Daniel Terranova Ríos, Carolina Andrea Urbina Carrera, Andrea Crespo Sedano, Daniel Álvarez González, Tomás Ruiz Albi, and Ana Cerezo Hernández
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medicine.medical_specialty ,COPD ,Asthma exacerbations ,business.industry ,Emergency medicine ,Air pollution ,Medicine ,In patient ,business ,medicine.disease_cause ,medicine.disease - Published
- 2020
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5. Detection of anti-Toxocara spp. antibodies in canines from a peri-urban area in the province of Heredia, Costa Rica
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F. Raúl Bermúdez-Salas, Natalia Guzmán-Gómez, Marta C. Bonilla, Gaby Dolz, Andrea Urbina-Villalobos, and Luis José Schmidt
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Veterinary medicine ,lcsh:Veterinary medicine ,seroprevalencia ,Zoonosis ,SEROPREVALENCE ,PERRO ,General Medicine ,zoonosis ,medicine.disease ,toxocara spp ,ZOONOSIS ,TOXOCARIASIS ,toxocariasis ,Toxoplasmosis ,Geography ,medicine ,Toxocariasis ,DOG ,perros ,lcsh:SF600-1100 ,Seroprevalence ,TOXOPLASMOSIS ,lcsh:Animal culture ,ZOONOTIC ,lcsh:SF1-1100 - Abstract
La toxocariasis es una enfermedad zoonótica cosmopolita causada por nemátodos del género Toxocara. Los perros son hospedadores definitivos de Toxocara canis y pueden ser asintomáticos o presentar signos clínicos inespecíficos. El ser humano puede infectarse y desarrollar diferentes patologías. En Costa Rica, se ha realizado estudios de prevalencia de huevecillos de Toxocara spp. en muestras de suelo y heces de caninos, pero no se ha investigado la prevalencia de anticuerpos contra este parásito en perros. Este estudio tiene como objetivo analizar 55 sueros de caninos de una comunidad periurbana de Heredia, Costa Rica, utilizando una prueba comercial para la detección de anticuerpos IgG anti-Toxocara spp. Además, se utilizó la información obtenida, mediante un cuestionario aplicado a las personas poseedoras de los perros, para conocer las prácticas de manejo con sus mascotas y el conocimiento sobre enfermedades zoonóticas. Se determinó una seroprevalencia de 29%, lo cual evidencia que los caninos se infectaron con este parásito en alguna etapa de su vida. Se comprueba un desconocimiento generalizado acerca de las enfermedades zoonóticas por parte de los propietarios de los caninos; la mayoría de ellos aplicaba prácticas de manejo inadecuadas, tales como: no recoger las heces de sus perros en sitios públicos, poca o ninguna atención veterinaria para sus mascotas y protocolos de desparasitación de sus animales sin guía profesional ni registros confiables, lo cual podría favorecer la infección de sus mascotas con parásitos zoonóticos. Toxocariasis is a cosmopolitan zoonotic disease caused by nematodes belonging to the genus To x o c a r a. Dogs are the definitive hosts of Toxocara canis and can develop non-specific clinical symptoms or remain asymptomatic. Humans can also become infected and develop different pathologies. Prevalence studies on To x o c a r a spp. eggs in soil samples and canine feces were conducted in Costa Rica; however, the prevalence of antibodies against this parasite in dogs has not been investigated yet. This study aimed to analyze 55 canine sera from a peri-urban community in Heredia, Costa Rica, using a commercial test for the detection of IgG antibodies against To x o c a r a spp. In addition, dog owners were asked to fill out a questionnaire to know pet management practices and verify their knowledge of zoonotic diseases.A 29% seroprevalence was determined, evidencing that canines had been infected with this parasite at some point in their lives. A general lack of knowledge about zoonotic diseases was determined among the owners, and most of them showed inadequate pet management practices such as not collecting canine feces in public places, little or no veterinary care, and deworming protocols without professional guidance or reliable records which could favor infection with zoonotic parasites. A toxocaríase é uma doença zoonótica cosmopolita causada por nematóides do gênero Toxocara. Os cães são hospedeiros definitivos do Toxocara canis e podem ser assintomáticos ou mostrar sinais clínicos inespecíficos. O ser humano pode ser infectado e desenvolver diferentes patologias.Em Costa Rica, foram realizados estudos de prevalência de ovos de To x o c a r a spp. em amostras de solo e fezes de cães, mas a prevalência de anticorpos contra esse parasita em cães ainda não tem sido investigado. Este estudo tem como objetivo analisar 55 soros caninos de uma comunidade periurbana de Heredia, Costa Rica, utilizando um teste comercial para a detecção de anticorpos IgG anti-To x o c a r a spp. Além disso, as informações obtidas, através de um questionário aplicado aos donos dos cães, foram utilizadas para conhecer as práticas de manejo com seus animais de estimação e o conhecimento sobre doenças zoonóticas.Foi determinada uma soroprevalência de 29%, o que mostra que os caninos foram infectados com esse parasita em algum estágio de sua vida. Existe um desconhecimento geral sobre doenças zoonóticas por parte dos proprietários caninos; a maioria deles aplicava práticas inadequadas de manejo, tais como: não coletar as fezes de seus cães em locais públicos, pouca ou nenhuma atenção veterinária para seus animais de estimação e protocolos de desparasitação para seus animais sem orientação profissional ou registros confiáveis, o que poderia favorecer a infecção de seus animais de estimação com parasitas zoonóticos. Escuela de Medicina Veterinaria
- Published
- 2020
6. What perception and knowledge about smoking have patients included in a Cardiac Rehabilitation Program?
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Milko Daniel Terranova Ríos, Ana Gómez García, Carmen Ainhoa Arroyo Domingo, Ana María Andrés Blanco, Ana Cerezo Hernández, Francisco Javier Pagán Buzo, Carolina Andrea Urbina Carrera, María Victoria García Gallardo, and Laura García
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medicine.medical_specialty ,Rehabilitation ,Descriptive statistics ,business.industry ,media_common.quotation_subject ,medicine.medical_treatment ,Infarction ,Disease ,medicine.disease ,Sudden death ,Perception ,Physical therapy ,Medicine ,Smoking cessation ,Observational study ,business ,media_common - Abstract
Background: Half of smokers will die of an illness related to smoking. The habitual consumption of cigarettes is attributed to 30% of cardiovascular accidents. For this reason, smoking(SMK) represents one of the main coronary risk factors. The patients who continue SMK after an acute coronary episode is not negligible, and relapse is frequent. The Smoking Subunits within the Cardiac Rehabilitation Programs(CRP)can facilitate the control of this drug dependence. Education is a basic step for prevention and SMK cessation. Aim: To evaluate the knowledge about SMK of patients in a CRP. Method: Observational study. Patients referred to the CRP who carried out a questionnaire on knowledge of SMK of the Spanish Society of Cardiology with several items:symptoms, treatment, recommendations, strategies, benefits of smoking cessation and the influence on cardiovascular diseases. Descriptive statistics were used. Result: 60 questionnaires were analyzed.90% of patients consider SMK a chronic disease with treatment. 40% believe that the treatments are effective.85% believe that we must take the positive decision to quit and include healthy habits. 90% think that passive smokers suffer from eye irritation and cough. 70% think that a balanced diet, exercise and a home smoke-free are recommended.80% think that SMK influences the aging of the skin, infarction, sudden death and fatigue.80% believe that a good strategy is to set a date. 95% think that SMK increases the risk of cardiovascular disease in the long term.70% know its physiopathological effects. Conclusion: The majority of patients included in a CRP have adequate knowledge about SMK. Tobacco education should be emphasized towards primary prevention.
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- 2019
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7. Repetitive Transcranial Magnetic Stimulation in adult patients with migraine: Report of 3 cases
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Andrea Urbina, Sahory Bautista, Edgar Castillo – Armas, Erick Carrillo, and José Ricardo López Melgar
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Adult patients ,business.industry ,General Neuroscience ,medicine.medical_treatment ,Biophysics ,medicine.disease ,lcsh:RC321-571 ,Transcranial magnetic stimulation ,Migraine ,Anesthesia ,medicine ,Neurology (clinical) ,business ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry - Published
- 2020
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8. Canine trypanosomiasis in an endemic Costa Rican community: Demonstration of the active infection cycle
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Marta C. Bonilla, Ruth Castro-Vásquez, Gaby Dolz, Andrea Urbina-Villalobos, and Marco Vinicio Herrero-Acosta
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Costa Rica ,Male ,Veterinary medicine ,Endemic Diseases ,Trypanosoma cruzi ,Antibodies, Protozoan ,Biology ,Polymerase Chain Reaction ,law.invention ,Serology ,Dogs ,CANINE TRYPANOSOMIASIS ,law ,Zoonoses ,medicine ,Prevalence ,Animals ,COSTA RICA ,Chagas Disease ,Dog Diseases ,Longitudinal Studies ,Seroconversion ,Fluorescent Antibody Technique, Indirect ,Polymerase chain reaction ,Phylogeny ,Spatial Analysis ,Indirect immunofluorescence ,General Veterinary ,Indirect hemagglutination ,Incidence ,SEROLOGY ,PERRO ,Hemagglutination Tests ,DNA, Protozoan ,medicine.disease ,Insect Vectors ,PCR ,Cross-Sectional Studies ,Microscopy, Fluorescence ,Housing ,Parasitology ,Female ,Seasons ,Triatominae ,Trypanosomiasis ,CANINE - Abstract
Proyecto: "FIDA "Distribución espacio-temporal del Trypanososma cuzi en perros y chinches en la comunidad de Getsemaní, San Rafael, Heredia" A cross-sectional study was conducted to determine the prevalence of canine trypanosomiasis in an endemic community of Costa Rica. The indirect hemagglutination and indirect immunofluorescence assay yielded positive results in 6.4% (20/314) of canine samples analyzed; polymerase chain reaction (PCR) and light microscopy yielded positive results in one dog. Subsequently, a longitudinal study was carried out with 55 negative T. cruzi canines in the cross-sectional study. These dogs were divided into two groups: Group 1, which consisted of 25 individuals that lived in dwellings where triatomines were found in their homes; and Group 2, which consisted of 30 dogs that lived in dwellings where triatomines were not found during the previous study in their homes. Seroconversion occurred in six dogs (10.9%) in Group 1 in the first months of the year (dry season); these dogs remained seropositive until the end of the study. Only one of the six seropositive canines was also found positive once in T. cruzi PCR. The analysis of the amplified T. cruzi sequences of dogs and triatomines showed that all of them belonged to the TcI lineage. It is recommended that residents be made aware of the need to eliminate vectors in their homes and their surroundings. Se realizó un estudio transversal para determinar la prevalencia de tripanosomiasis canina en una comunidad endémica de Costa Rica. El ensayo de hemaglutinación indirecta e inmunofluorescencia indirecta arrojó resultados positivos en 6,4% (20/314) de muestras caninas analizadas; La reacción en cadena de la polimerasa (PCR) y la microscopía óptica arrojaron resultados positivos en un perro. Posteriormente, se realizó un estudio longitudinal con 55 caninos negativos de T. cruzi en el estudio transversal. Estos perros se dividieron en dos grupos: el Grupo 1, que consistía en 25 individuos que vivían en viviendas donde se encontraban triatominos en sus hogares; y el Grupo 2, que consistía en 30 perros que vivían en viviendas donde no se encontraron triatominos durante el estudio anterior en sus hogares. La seroconversión ocurrió en seis perros (10.9%) en el Grupo 1 en los primeros meses del año (estación seca); estos perros permanecieron seropositivos hasta el final del estudio. Solo uno de los seis caninos seropositivos también resultó positivo una vez en T. cruzi PCR. El análisis de las secuencias amplificadas de T. cruzi de perros y triatominos mostró que todos ellos pertenecían al linaje TcI. Se recomienda que los residentes sean conscientes de la necesidad de eliminar los vectores en sus hogares y sus alrededores. FUNDAUNA Escuela de Medicina Veterinaria
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- 2018
9. Efectividad de la férula U-Mano en el tratamiento del síndrome del túnel del carpo
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Claudia Andrea Urbina
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medicine.medical_specialty ,Flexor tendon ,biology ,business.industry ,Therapeutic treatment ,medicine.medical_treatment ,biology.organism_classification ,medicine.disease ,Computer users ,Surgery ,medicine.anatomical_structure ,General Earth and Planetary Sciences ,Medicine ,Carpal tunnel ,business ,Carpal tunnel syndrome ,Splint (medicine) ,Ferula ,General Environmental Science - Abstract
El síndrome del túnel del carpo (STC) es el trauma acumulativo más frecuente del mundo y la patología que los usuarios de computador sufren con mayor regularidad; es así como en terapia ocupacional este síndrome constituye un gran porcentaje de los motivos de consulta. El tratamiento terapéutico del STC, tiene como objetivo minimizar la inflamación, reducir el dolor y mantener el deslizamiento normal de los tendones flexores dentro del túnel del carpo, mediante un programa, modificación de la actividad, técnicas de protección articular y de conservación de energía. El objetivo del presente trabajo es evaluar la efectividad de la férula U-Mano para el tratamiento del STC, basandose en la relación costo/beneficio para los pacientes, en comparación con la férula convencional utilizada en el medio.
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- 2017
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10. Molecular and serological rapid tests as markers of Trypanosoma cruzi infection in dogs in Costa Rica
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Victor M Montenegro, Marlen Cordero, Albert Picado, Regina Lizundia, Alejandra Calderón, Andrea Urbina, and Stijn Deborggraeve
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Chagas disease ,Costa Rica ,Trypanosoma cruzi ,Coris ,Diagnostic tools ,Zoonotic disease ,diagnostic tools ,Serology ,rapid test ,parasitic diseases ,medicine ,Screening tool ,COSTA RICA ,Triatominae ,T. cruzi-Detect ,OligoC-TesT ,biology ,CHAGAS DISEASE ,TRYPANOSOMA CRUZI ,TRYPANOSOMA ,biology.organism_classification ,medicine.disease ,Asymptomatic infections ,Virology ,Chagas ,Original Article ,ENFERMEDAD DE CHAGAS - Abstract
Chagas disease is a zoonotic disease caused by Trypanosoma cruzi and dogs are one of the main domestic reservoirs. Materials and Methods: One molecular (OligoC‑TesT, Coris Bioconcept) and one serological (T. cruzi‑Detect, Inbios) rapid tests were evaluated as infection markers for T. cruzi in 102 dogs living in eight villages endemic for Chagas in Costa Rica. Results: T. cruzi‑Detect performed well as screening tool with 23.3% positive samples. The large number of invalid results (66.7%) observed in samples tested with OligoC‑TesT precluded assessing the use of this new method as epidemiological tool to detect T. cruzi infection in dogs. La enfermedad de Chagas es una enfermedad zoonótica causada por el Trypanosoma cruzi y los perros son uno de los principales reservorios domésticos. Materiales y métodos: Un molecular (OligoC-TesT, Coris Bioconcept) y una serológica (T. cruzi-Detect, Inbios) de T. cruzi en 102 perros que viven en ocho pueblos endémicos de Costa Rica. de Chagas en Costa Rica. Resultados: T. cruzi-Detect funcionó bien como herramienta de cribado con un 23,3% de muestras positivas. El gran número de resultados no válidos (66,7%) observado en las muestras analizadas con OligoC-TesT impidió evaluar el uso de este nuevo método como herramienta epidemiológica para detectar la infección por T. cruzi en perros. Universidad Nacional, Costa Rica Escuela de Medicina Veterinaria
- Published
- 2014
11. Zymodeme and Serodeme Characterization of Leishmania Isolates Obtained from Costa Rican Patients
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Johnny Peraza, Rodrigo Zeledón, and Andrea Urbina
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Male ,RC955-962 ,lcsh:QR1-502 ,Fluorescent Antibody Technique ,lcsh:Microbiology ,Antibody Specificity ,Antibodies monoclonal ,Arctic medicine. Tropical medicine ,EPIDEMIOLOGY ,characterization ,Isoenzyme electrophoresis ,Child ,Leishmania guyanensis ,Aged, 80 and over ,Leishmania ,Leishmania panamensis ,etiological agent ,biology ,Antibodies, Monoclonal ,Middle Aged ,QR1-502 ,Isoenzymes ,population characteristics ,Female ,ENFERMEDAD DE CHAGAS ,geographic locations ,Adult ,Microbiology (medical) ,Costa Rica ,lcsh:Arctic medicine. Tropical medicine ,Adolescent ,lcsh:RC955-962 ,Leishmaniasis, Cutaneous ,Microbiology ,Leishmania braziliensis ,medicine ,Animals ,Humans ,leishmaniasis ,Aged ,Infant ,Leishmaniasis ,Electrophoresis, Cellulose Acetate ,CHAGAS DISEASES ,biology.organism_classification ,medicine.disease ,Immunology ,EPIDEMIOLOGIA - Abstract
Human leishmaniasis is widespread through- out Central America and constitutes an important public health problem. Annual incidence is esti- mated to be about 20,000 cases (Carreira et al. 1995), of which 4,000 to 5,000 correspond to Costa Rica (Zeledón 1992). The disease exists under dif- ferent clinical manifestations and in a variety of ecological and epidemiological patterns (Zeledón 1985) making it a complex problem that is diffi- cult to manage. The identity of the Leishmania species involved is a factor that largely determines the clinical mani- festations of the disease (Lainson & Shaw 1987, Alexander & Russell 1992) and its response to treatment (Navin et al. 1992, Grogl et al. 1992). The World Health Organization (WHO 1990) rec- ommends isoenzyme electrophoresis and the use of specific monoclonal antibodies as appropriate methods for characterizing Leishmania. In Costa Rica, although it is known that L. panamensis species is the principal etiological agent of leishmaniasis (Zeledón 1992), there are no detailed and extensive taxonomic studies of the implicated parasites in different areas of the coun- try. Here, we report the identification by isoenzyme electrophoresis and indirect immunofluorescence (IFA) with monoclonal antibodies of 34 Leishma- nia strains, isolated from different geographical and ecological areas of Costa Rica, from patients with cutaneous leishmaniasis. La leishmaniasis humana está extendida por toda América Central y constituye un importante problema de salud pública. La incidencia anual se estima en unos 20.000 casos (Carreira et al. 1995), de los cuales entre 4.000 y 5.000 corresponden a Costa Rica (Zeledón 1992). La enfermedad se presenta bajo diferentes manifestaciones clínicas y en una variedad de patrones ecológicos y epidemiológicos (Zeledón 1992). Patrones ecológicos y epidemiológicos (Zeledón 1985), lo que la convierte en un problema complejo y de difícil manejo. La identidad de la especie de Leishmania implicada es un factor que determina infestaciones clínicas de la enfermedad (Lainson & Shaw 1987, Alexander & Russell 1992) y su respuesta al tratamiento tratamiento (Navin et al. 1992, Grogl et al. 1992). La Organización Mundial de la Salud (OMS 1990) recomienda la electroforesis isoenzimática y el uso de anticuerpos monoclonales específicos como métodos de anticuerpos monoclonales como métodos apropiados para la caracterización de Leishmania. En Costa Rica, aunque se sabe que la especie L. panamensis es el principal agente etiológico de la leishmaniasis (Zeledón 1992), no existen estudios taxonómicos detallados y extensos de los parásitos implicados en las diferentes zonas del país. En este caso, informamos de la identificación por electroforesis isoenzimática electroforesis e inmunofluorescencia indirecta (IFA) con anticuerpos monoclonales de 34 cepas de Leishma- nia, aisladas en diferentes zonas geográficas y ecológicas de zonas geográficas y ecológicas de Costa Rica, procedentes de pacientes con leishmaniasis cutánea. Universidad Nacional, Costa Rica Escuela de Medicina Veterinaria
- Published
- 1998
12. Does a spontaneous cure for chagas' disease exist?
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A. Brilla-Salazar, Luis G. Vargas, Rodrigo Zeledón, Andrea Urbina, João Carlos Pinto Dias, and J. Marcondes de Rezende
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Adult ,Costa Rica ,Male ,Microbiology (medical) ,Chagas disease ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,Heart malformation ,Remission, Spontaneous ,Incomplete block ,Spontaneous remission ,Disease ,Gastroenterology ,Serology ,Doença de Chagas ,Estudo longitudinal ,Tripanosomiase americana ,Internal medicine ,medicine ,Humans ,Chagas Disease ,Longitudinal Studies ,Right bundle branch ,business.industry ,Longitudinal studies ,Middle Aged ,medicine.disease ,Surgery ,Chagas' disease ,Infectious Diseases ,Cura espontânea ,Spontaneous cure ,Female ,Parasitology ,business ,American trypanosomiasis - Abstract
Six Costa Rican Chagas' disease patients, with wellknown acute phase history and no specific treatment were examined in several occasions during 39, 24, 32, 16 and 14 years, respectively, from the onset. Nome of the patients presented heart abnormalities as revealed by the conventional EKG and ergometry, exceptfor one of them with an incomplete block of the right bundle branch. Also, no alterations of the oesophagus motility was detected manometrically except for another patient who presented a slight hypersensivity reaction to a pharmacological test (Mecholyl). Three out of six patients became serologically negative in 1981, remaining as such until 1986. Besides the conventional serology, the search of protective ("lytic") antibodies was also performed in 1985 and 1986, being completely negative in one of the "cured" patients and dubious in the other two. The hypothesis that these three patients had as spontaneous cure, based on the clinical, serological and parasitologica l findings is discussed.Um grupo de pacientes com doença de Chagas vem sendo acompanhado desde a fase aguda, na Costa Rica, com tempos de evolução entre 14 e 44 anos (mediana de 32 anos). Em todos a doença aguda foi bem comprovada, não sendo realizado tratamento específico em nenhum deles, contra o Trypanosoma cruzi. Todos apresentaram pelo menos uma sorologia positiva ao longo da fase crônica, mas em três deles as técnicas sorológicas convencionais se tomaram parmanentemente negativas em diversos exames ealizados em diferentes laboratórios, entre 1981 e 1986. Nestes três pacientes também a pesquisa de anticorpos líticos foi negativa (um caso) ou negativo-duvidosa (dois casos), permanecendo consistentemente positiva nos três outros pacientes com sorologia convencional reagente. Atualmente todos os seis pacientes se apresentam assintomáticos e com xenodiagnóstico negativo. Apenas um deles apresenta distúrbio eletrocardiogràfico mínimo e inespecífico (bloqueio incompleto do ramo direito) e, um outro, pequeno retardo do trânsito esofagiano à prova de metacolina. Levanta-se a hipótese de cura espontânea da doença de Chagas, fato que deve ser raro e que merece maior investigação.
- Published
- 1988
13. Atypical cutaneous leishmaniasis in a semiarid region of north-west Costa Rica
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Harry Hidalgo, Rodrigo Zeledón, Abel Víquez, and Andrea Urbina
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medicine.medical_specialty ,Public Health, Environmental and Occupational Health ,Leishmaniasis ,General Medicine ,medicine.disease ,Dermatology ,Surgery ,Infectious Diseases ,Geography ,Cutaneous leishmaniasis ,North west ,medicine ,Parasitology ,Protozoal disease - Abstract
Cette forme a ete observee chez environ 200 personnes, surtout des enfants, entre 1986 et 1987. Il s'agit des petits nodules de 2 a 10 mm n'ayant aucune tendance a l'ulceration ou encore de petites papules ou plaques erythemateuses chroniques
- Published
- 1989
- Full Text
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