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4 results on '"AP-HP Hôpital A. Chenevier [Créteil]"'

1. Risk of Severe Bacterial Infection in People Living Human Immunodeficiency Virus Infection in the Combined Antiretroviral Therapy Era

Author

Murielle Mary-Krause, Sébastien Gallien, Martin Siguier, Dominique Costagliola, Hugues Melliez, Patricia Enel, Patrizia Carrieri, Juliette Pavie, Xavier Duval, Pierre Tattevin, Marguerite Guiguet, Claudine Duvivier, Anaenza Freire-Maresca, Sophie Abgrall, Dupuis, Christine, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Département des Maladies Infectieuses [CH Tourcoing] (Hôpital Gustave Dron), Centre Hospitalier Gustave Dron [Tourcoing]-Centre Hospitalier de Tourcoing, Hôpital de la Région de Saint-Omer [Helfaut], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Service de médecine interne, immunologie clinique [Béclère], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de santé publique et information médicale [Hôpital de la Conception - APHM], Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Service d'Immunologie Clinique et Maladies Infectieuses [AP-HP Hôpital H. Mondor-A. Chenevier, Paris], Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-AP-HP Hôpital A. Chenevier [Créteil], Services de Maladies Infectieuses et Tropicales [CHU Bichat], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Médical de l'Institut Pasteur (CMIP), Institut Pasteur [Paris] (IP), Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Service d'Immunologie Clinique [Hôpital Européen Georges Pompidou - APHP], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de maladies infectieuses et tropicales [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Service de médecine interne [CHU Ambroise Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], France Recherche Nord&Sud Sida-hiv Hépatites, Institut National de la Santé et de la Recherche Médicale, French Ministry of Health, Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Antoine Béclère [Clamart], Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Hôpital Henri Mondor-AP-HP Hôpital A. Chenevier [Créteil], Institut Pasteur [Paris], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Université de Paris (UP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Centre Médical de l'Institut Pasteur, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut Pasteur [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Service des maladies infectieuses et réanimation médicale [Rennes], Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou

Subjects
Male, 0301 basic medicine, Databases, Factual, Neutrophils, [SDV]Life Sciences [q-bio], HIV Infections, Comorbidity, Leukocyte Count, Liver disease, 0302 clinical medicine, Risk Factors, Immunology and Allergy, Prospective Studies, 030212 general & internal medicine, diabetes, Incidence, Incidence (epidemiology), Hazard ratio, Bacterial Infections, Middle Aged, 3. Good health, [SDV] Life Sciences [q-bio], Alcoholism, Infectious Diseases, Anti-Retroviral Agents, Drug Therapy, Combination, Female, France, liver disease, Adult, medicine.medical_specialty, Neutropenia, Malignancy, Risk Assessment, AIDS-defining malignancy, End Stage Liver Disease, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Humans, Renal Insufficiency, Chronic, Aged, business.industry, HIV, medicine.disease, Confidence interval, 030104 developmental biology, HIV-1, business, chronic kidney disease, Kidney disease
Abstract

BackgroundSevere bacterial infections are the first cause of morbidity in people with human immunodeficiency virus (PWH). We aimed to assess their incidence and to analyze their determinants.MethodsWe studied human immunodeficiency virus (HIV)-1-infected individuals aged at least 15 years and prospectively followed between 2006 and 2015 in the French Hospital Database on HIV. The Andersen and Gill model was used to calculate the adjusted hazard ratios (HRs), focusing on heavy alcohol use and neutrophil function-altering comorbidities.ResultsOf 25 795 participants, 1414 developed 1883 severe bacterial infections. Between 2006 and 2009 and 2013 and 2015, the incidence fell from 13.2 (95% confidence interval [CI], 12.3–14.1) to 7.1 (95% CI, 6.3–7.8) per 1000 person-years. Heavy alcohol use was associated with an increased risk of severe bacterial infection (HR = 1.3, 95% CI = 1.1–1.7 for 40–80 g/day and HR = 1.6, 95% CI = 1.2–2.1 for >80 g/day), as were diabetes, chronic kidney disease, and end-stage liver disease (HR = 1.2, 95% CI = 1.0–1.4 when 1 comorbidity; HR = 2.3, 95% CI = 1.6–3.4 when more than 1 comorbidity), and nonacquired immune deficiency syndrome-defining malignancy (HR = 2.0; 95% CI, 1.6–2.4).ConclusionsHeavy alcohol use was associated with an increased risk of severe bacterial infection, as were neutrophil function-altering comorbidities. Controlled-drinking approaches should be promoted and comorbidity management should be strengthened in PWH.

Published
2020
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2. Unilateral recurrent laryngeal nerve palsy post-thyroidectomy: Looking for hyperventilation syndrome

Author

Laurent Boyer, Françoise Zerah-Lancner, Jean-François Papon, André Coste, E. Bequignon, H. Dang, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Cytosquelette et développement (CD), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AP-HP Hôpital A. Chenevier [Créteil], Hôpital Henri Mondor, Centre Hospitalier Intercommunal de Créteil (CHIC), Biomécanique & Appareil Respiratoire (BAR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), and CCSD, Accord Elsevier

Subjects
Adult, Male, Hyperventilation syndrome, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Unilateral vocal fold paralysis, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Swallowing, Hyperventilation, medicine, Recurrent laryngeal nerve, Humans, Prospective Studies, 030223 otorhinolaryngology, Aged, Palsy, Lung, Hypocapnia, Recurrent Laryngeal Nerve palsy, business.industry, Thyroidectomy, Syndrome, Middle Aged, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Dyspnea, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Anesthesia, Arterial blood, Female, Surgery, Blood Gas Analysis, medicine.symptom, business, Vocal Cord Paralysis, Alkalosis, Respiratory
Abstract

International audience; Aims: Unilateral Recurrent Laryngeal Nerve (RLN) palsy is responsible for dysphonia and difficulties in swallowing. The role of unilateral RLN palsy on dyspnea is not fully elucidated. Our hypothesis is that air leak could be responsible for development of hyperventilation syndrome (HVS).Objective: The objective of this study was to determine in patients with unilateral RLN palsy if dyspnea could be associated with HVS.Material and methods: Over a 12-month period, all patients with permanent unilateral RLN palsy after thyroidectomy complaining from the onset of unexplained dyspnea were tested. Measurement of Nijmegen score, an hyperventilation test, an arterial blood gas, lung function and cardiac tests were performed. The diagnosis of HVS was defined if at least two criteria were present among: Nijmegen score>23; reproduction of at least 2 usual symptoms during hyperventilation test; an expirated pressure of CO2 (EpCO2)

Published
2019
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3. No Positive Association between Vitamin D Level and Immune Responses to Hepatitis B and Streptococcus pneumoniae Vaccination in HIV-Infected Adults

Author

Alex Assuied, Rodolphe Thiébaut, Yves Levy, Jean-Claude Souberbielle, Jean-Paul Viard, Fabrice Carrat, Laura Richert, Odile Launay, Geneviève Chêne, Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Vaccine Research Institute (VRI), CHU Necker - Enfants Malades [AP-HP], CHU Bordeaux [Bordeaux], Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Université Paris Descartes - Paris 5 (UPD5)-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM), Vaccine Research Institute [Créteil, France] (VRI), HAL UPMC, Gestionnaire, Assistance publique - Hôpitaux de Paris (AP-HP), Université Paris Descartes - Faculté de Médecine ( UPD5 Médecine ), Université Paris Descartes - Paris 5 ( UPD5 ), Institut de Santé Publique, d'Epidémiologie et de Développement ( ISPED ), INSERM U955, équipe 16, Vaccine Research Institute ( VRI ), Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Institut Mondor de Recherche Biomédicale ( IMRB ), Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR10-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR10, Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Service d'Immunologie Clinique et Maladies Infectieuses [AP-HP Hôpital H. Mondor-A. Chenevier, Paris], Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -AP-HP Hôpital Henri Mondor (Créteil)-AP-HP Hôpital A. Chenevier [Créteil], Statistics In System biology and Translational Medicine ( SISTM ), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), CHU Saint-Antoine [APHP], CIC Cochin Pasteur ( CIC 1417 ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP]-Hôtel-Dieu-Université Paris Descartes - Paris 5 ( UPD5 ) -Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale ( INSERM ), F-CRIN, I-REIVAC, and Institut National de la Santé et de la Recherche Médicale ( INSERM )

Subjects
0301 basic medicine, Male, Physiology, Gastroenterology and hepatology, Antibody Response, Organic chemistry, lcsh:Medicine, medicine.disease_cause, Biochemistry, Hepatitis, Pneumococcal Vaccines, 0302 clinical medicine, Immune Physiology, Medicine and Health Sciences, Medicine, Public and Occupational Health, 030212 general & internal medicine, Vitamin D, lcsh:Science, Immune Response, Vaccines, Multidisciplinary, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Immune System Proteins, biology, Vitamins, Hepatitis B, Middle Aged, Vaccination and Immunization, 3. Good health, Vaccination, Physical sciences, Titer, Chemistry, Infectious hepatitis, Streptococcus pneumoniae, Nutritional deficiencies, Infectious diseases, Female, Antibody, Research Article, Adult, medicine.medical_specialty, Immunology, Viral diseases, Antibodies, 03 medical and health sciences, Chemical compounds, Immune system, Internal medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Organic compounds, Vitamin D and neurology, Humans, Hepatitis B Vaccines, Hepatitis B Antibodies, Liver diseases, Nutrition, Vitamin D deficiency, business.industry, lcsh:R, Biology and Life Sciences, Proteins, medicine.disease, Confidence interval, 030104 developmental biology, Immunoglobulin G, biology.protein, lcsh:Q, Preventive Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; ObjectiveTo assess whether higher 25-hydroxyvitamin D (25OHD) levels are associated with subsequent better immune responses to hepatitis B and Streptococcus pneumoniae vaccination in HIV-infected patients.Methods25OHD was measured on stored baseline plasma samples from two randomized vaccine trials in HIV-infected adults: the ANRS HB03 VIHVAC B trial and an immunological sub-study of the ANRS 114-PNEUMOVAC trial. In ANRS HB03 VIHVAC B, participants received three or four doses of recombinant HBV vaccine strategies. Anti-HBs IgG titers were measured four weeks after the last injection. Associations between baseline 25OHD levels and ordered IgG response categories were analyzed in multivariable proportional odds models. In the ANRS 114-PNEUMOVAC sub-study, two strategies of pneumococcal vaccination were tested, cellular immune responses were measured at repeated time points, and IgG responses four weeks after the last vaccine injection. Exploratory statistical analyses were performed on this sub-study data set.ResultsThree hundred and thirty-nine ANRS HB03 VIHVAC B and 25 ANRS 114-PNEUMOVAC sub-study participants were included in the analyses. Median age in each of the two studies was 43 years, 68% were male, and 77–92% on antiretroviral treatment. Median 25OHD level was 18 ng/mL (IQR: 12–25) and 24 ng/mL (IQR: 13–32) in the two trial populations, respectively. In the multivariable model, there was no significant association between baseline 25OHD level and vaccine responses in ANRS HB03 VIHVAC B (proportional odds ratio 0.83 per 10 ng/mL 25OHD increase; 95% confidence interval 0.65–1.07, p = 0.14). Exploratory analyses of ANRS 114-PNEUMOVAC showed consistent results.ConclusionThis study does not support a positive association between 25OHD and immune responses to hepatitis B or pneumococcal vaccination in HIV-infected patients.

Published
2016
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4. Rituximab for prevention of delayed hemolytic transfusion reaction in sickle cell disease

Author

Marc Michel, Dora Bachir, Frédéric Galactéros, F. Noizat-Pirenne, Philippe Chadebech, Jean-Claude Lecron, Anne Plonquet, Philippe Bierling, Etablissement Français du Sang [Île-de-France Mondor], Centre de référence des cytopénies auto-immunes [CHU Mondor] (CeReCAI), CHU Henri Mondor, Unité des Maladies Génétiques du Globule Rouge [CHU Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de médecine interne [Mondor], Service d'Immunologie Clinique et Maladies Infectieuses [AP-HP Hôpital H. Mondor-A. Chenevier, Paris], Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-AP-HP Hôpital A. Chenevier [Créteil], Laboratoire Cytokines et Inflammation, Université de Poitiers, and CHADEBECH, Philippe

Subjects
Adult, Erythrocytes, Exacerbation, Cell, Disease, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Anemia, Sickle Cell, 030204 cardiovascular system & hematology, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Hemolysis, 03 medical and health sciences, Antibodies, Monoclonal, Murine-Derived, 0302 clinical medicine, Second line, Hemoglobin drop, hemic and lymphatic diseases, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Medicine, Humans, Immunologic Factors, Autoantibodies, B-Lymphocytes, business.industry, Antibodies, Monoclonal, Hematology, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, medicine.disease, 3. Good health, Delayed hemolytic transfusion reaction, medicine.anatomical_structure, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Immunology, Rituximab, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Anemia, Hemolytic, Autoimmune, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, business, Complication, Erythrocyte Transfusion, 030215 immunology, medicine.drug
Abstract

International audience; Delayed hemolytic transfusion reaction (DHTR), a life-threatening transfusion complication in sickle cell disease (SCD), is characterized by a marked hemoglobin drop with destruction of both transfused and autologous red blood cells (RBCs) and exacerbation of SCD symptoms. One mechanism of RBCs destruction is auto-antibody production secondary to transfusion. As rituximab specifically targets circulating B cells, we thought that it could be beneficial in preventing this immune-mediated transfusion complication. We report the case of a SCD patient who previously experienced DHTR with auto-antibodies and who needed a new transfusion. DHTR recurrence was successfully prevented by rituximab administration prior transfusion, supporting the safe use of rituximab to prevent DHTR in SCD patients as a second line approach when other measures failed.

Published
2007
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