1. Fascial thickness and stiffness in hypermobile <scp>Ehlers‐Danlos</scp> syndrome
- Author
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Tina J. Wang and Antonio Stecco
- Subjects
musculoskeletal diseases ,Iliac fascia ,Pain ,Iliotibial tract ,Prevalence ,Genetics ,medicine ,Back pain ,Humans ,Fascia ,Genetics (clinical) ,business.industry ,Ultrasound ,Anatomy ,musculoskeletal system ,medicine.disease ,Extracellular Matrix ,body regions ,medicine.anatomical_structure ,Knee pain ,Ehlers–Danlos syndrome ,Ehlers-Danlos Syndrome ,Deep fascia ,medicine.symptom ,business - Abstract
There is a high prevalence of myofascial pain in people with hypermobile Ehlers-Danlos Syndrome (hEDS). The fascial origin of pain may correspond to changes in the extracellular matrix. The objective of this study was to investigate structural changes in fascia in hEDS. A series of 65 patients were examined prospectively-26 with hEDS, and 39 subjects with chronic neck, knee, or back pain without hEDS. The deep fascia of the sternocleidomastoid, iliotibial tract, and iliac fascia were examined with B-mode ultrasound and strain elastography, and the thicknesses were measured. Stiffness (strain index) was measured semi-quantitatively using elastography comparing fascia to muscle. Differences between groups were compared using one-way analysis of variance. hEDS subjects had a higher mean thickness in the deep fascia of the sternocleidomastoid compared with non-hEDS subjects. There was no significant difference in thickness of the iliac fascia and iliotibial tract between groups. Non-hEDS subjects with pain had a higher strain index (more softening of the fascia with relative stiffening of the muscle) compared with hEDS subjects and non-hEDS subjects without back or knee pain. In myofascial pain, softening of the fascia may occur from increase in extracellular matrix content and relative increase in stiffness of the muscle; this change is not as pronounced in hEDS.
- Published
- 2021