1. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children
- Author
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Theresa W. Guilbert, Leonard B. Bacharier, David T. Mauger, Wanda Phipatanakul, Stanley J. Szefler, Susan Boehmer, Avraham Beigelman, Anne M. Fitzpatrick, Daniel J. Jackson, Sachin N. Baxi, Mindy Benson, Carey-Ann D. Burnham, Michael D. Cabana, Mario Castro, James F. Chmiel, Ronina Covar, Michael Daines, Jonathan M. Gaffin, Deborah A. Gentile, Fernando Holguin, Elliot Israel, H. William Kelly, Stephen C. Lazarus, Robert F. Lemanske, Ngoc Ly, Kelley Meade, Wayne Morgan, James Moy, J. Tod Olin, Stephen P. Peters, Jacqueline A. Pongracic, Hengameh H. Raissy, Kristie Ross, William J. Sheehan, Christine Sorkness, W. Gerald Teague, Shannon Thyne, Fernando D. Martinez, Lisa Bartnikas, Alisha Bouzaher, Christopher Burke, Matthew Cavanaugh, Julia Chen, Elizabeth Cunningham, Amparito Cunningham, James Friedlander, Enal Hindi, David Kantor, Perdita Permaul, Devako Rao, Melinda Rossi, Doris Schierembergg, Kynda Schneider, Jennifer Troung, Dale Umetsu, Joseph Zhou, Jill Chmielewski, Anna Fishbein, Iliana Flexas, Ramsay Fuleihan, Rajesh Kumar, James Lane, Melanie Makhija, Louis Martos, Brandon Parker, Benjamin Prince, Nashmia Qamar, Mary Riordan, Rachel Robinson, Waheeda Samady, Christine Szychlinski, Daniel Tsang, Christopher Codispoti, Juan Fu, Grace Li, Diana Munoz-Mendoza, Benjamin Thompson, Melanie Gleason, Sakari Graves, Jonathan Malka, Melanie Phillips, Gayle Spears, D. Sundstrom, Michael White, Christina Batson, Lea Davies, Franceska Kelly, Esmeralda Morales, Abby Redway, Mary Spicher, Lauren Kaminski, Megan R. Knutson, Kelly Miller, Jennifer Promer, Sheila Turcsanyi, Tanya Watson, Shean Aujla, John Broyles, Hey Chong, Patricia Dubin, Jonathan Finder, Todd D. Green, Lori Holt, Adam Kufen, Geoffrey Kurland, Rose Lanzo, David Nash, Julianne Parente, Catherine Smith, Jonathan Spahr, Daniel J. Weiner, Daniel Craven, Danielle Goetz, Meeghan Hart, Leigh A. Kerns, Laurie Logan, Ross Myers, Laura Veri, Erica Butler, Jennifer Maiolo, Sara Misplay, David Skoner, Glennys Smith, Wanda Caldwell, Courtney Dula, Alysa Ellis, Caroline Horner, Lila Kertz, Tina Norris, Katherine Rivera-Spoljaric, Oscar Rodriguez, Robert Strunk, Jessica Bowman, Vicky Bowyer, Judy Gonzales-Vargas, Sara Hawkey, Susannah McCormick, Michelle McKean, Dan Shapiro, Katherine Tom, Jason Decker, Keonna Harrison, Dayna Long, Jyothi Marbin, Robert Mok, Cindy Nelson-Purdy, Dennis Ren, Hollie Stessel, Deb Green, Denise Thompson-Batt, Kristin Wavell, Donna Wolf, Timothy Beaty, Alice C. Bruce, Karen DeMuth, Jennifer Dodds, Shaneka Douglas, Dawn M. Simon, Denise Whitlock, Shanae Brown, Matthew Bowman, Loretta Doty, Linda Ferrari, Beth Gern, Dave Mauger, Aimee Merchlinski, James Schmidt, Daniel Tekely, Lindsay Texter, Angela Updegrave, and Ronald Zimmerman
- Subjects
Pediatrics ,medicine.medical_specialty ,Allergy ,Adrenal cortex hormones ,Immunology ,education ,MEDLINE ,Article ,03 medical and health sciences ,0302 clinical medicine ,Adrenal Cortex Hormones ,030225 pediatrics ,Administration, Inhalation ,and Blood Institute's AsthmaNet ,medicine ,Immunology and Allergy ,Humans ,Respiratory sounds ,Child ,Preschool ,Lung ,Asthma ,Respiratory Sounds ,medicine.diagnostic_test ,Inhalation ,business.industry ,National Heart ,medicine.disease ,Clinical trial ,medicine.anatomical_structure ,030228 respiratory system ,Child, Preschool ,Administration ,business - Abstract
Summary This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.
- Published
- 2018