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Abstract Background Forensic anthropological examinations help in identification of unidentified human remains. This study aims to establish population-specific standards for age estimation from the sternal ends of left fourth ribs in the Nepalese population. A quantitative, observational study was conducted on 387 Nepalese deceased (106 females, 281 males) between November 2021 and March 2023. Left fourth ribs were collected, macerated and examined for the study. The variables examined included pit depth, pit shape, rim and wall configurations and rib phase. Results Pit depth significantly predicted age, β = 0.642, t(385) = 16.42, p

Background: Cricoid cartilage is crucial during endotracheal intubation, yet its dimensions in the Nepali population remain uncharacterized. This study aimed to measure cricoid cartilage dimensions in adult Nepalese. Methods: A total of 105 cadavers (75 males, 30 females) were dissected at *** Medical Campus, Nepal. Measurements of outer and inner transverse and anteroposterior diameters, as well as heights of the cricoid arch and lamina, were taken using digital vernier calipers. Statistical analyses included gender comparisons and correlations with age. Results: The mean age of the 105 cadavers studied was 34.11 years (SD = 12.08). The measurements of outer anteroposterior diameter, outer transverse diameter, inner anteroposterior diameter, inner transverse diameter, arch height and lamina height were respectively 22mm (SD=4), 21mm (SD=4), 18mm (SD=3), 17mm (SD=3), 9mm (SD=3) and 24mm (SD=4). Inner AP (p = 0.009) and inner TR (p = 0.021) measurements correlated significantly with age. Males had significantly larger cricoid cartilage dimensions than females (p < 0.001). Conclusions: This study provided essential data for selecting appropriately sized endotracheal tubes in Nepalese patients, reducing airway complications. It underscored the need to tailor medical devices to local anatomical variations, supporting advancements in biomechanical modeling and medical research.

Introduction: Mandibular premolars are considered an enigma in dentistry because of their variability in anatomical and morphological features making it difficult to treat endodontically. This study was conducted to determine the root and canal morphology of mandibular premolars in the Nepalese population by using cone beam computed tomography imaging. Methods: One hundred and thirty-four cone beam computed tomography images of the Nepalese population were collected by convenience sampling method from April 1 to August 31, 2022 in Bir Hospital, Kathmandu, Nepal. A total of 536 premolars (268 mandibular first premolars and 268 mandibular second premolars) were evaluated by two examiners (one endodontist and one oral radiologist). Canal configuration was classified according to Vertucci’s classification. Results: In mandibular premolar teeth, the majority had one root followed by two roots and fused roots. The most common configuration in mandibular premolars was Vertucci’s type I (83.88% and 96.65% in the first and second premolar respectively) followed by type V (9.89%) in the first premolar and type III (1.86%) in the second premolar. Vertucci’s type VII (0.37%), C-shaped configuration (1.46%), and an unusual configuration (0.37%) were observed in the first premolar. In mandibular first premolars, males showed more variation than females; while in second premolars, females showed more variation than males. Conclusions: Mandibular premolar teeth showed variation in root and canal morphology with one root and Vertucci’s type I in the majority of the cases.

Introduction: Hypertension and Diabetes are two major risk factors for atherosclerotic disease. Carotid artery intima media thickness(cIMT) is considered a reliable surrogate measure for diagnosing subclinical atherosclerosis, its progression and regression. Paucity of available data regarding mean value of cIMT highlights the importance of defining the cut off value of cIMT in a specified population. Very limited studies have been done on sonographic evaluation of mean cIMT and carotid artery injury in hypertension and diabetes in Nepalese population. This study, therefore aims to determine mean cIMT in Nepalese population and to analyze effect of Hypertension and diabetes on cIMT. Methods: Cross-sectional hospital based study was conducted within the period of 18 months. B-mode ultrasound was used to measure cIMT in bilateral common carotid arteries. Comparison of mean cIMT was done amongst healthy, hypertensive and diabetes with hypertensive patients. Duration of disease was also considered. Data analysis was done with “R” analytical study. Results were expressed as mean ± standard deviation. Results: Total1005 (508 female and 497 male) adult patients with age range of 30 to 85 years were assessed. Among these 329(32.74%) were healthy adults, 341(33.93%) were hypertensive and 335(33.33%) were diabetes with hypertensive patients. The mean cIMT in cases was more than controls (P < 0.001) bilaterally with diabetes having an additive effect. There was also positive correlation of measured value with duration of disease and age of patients. Conclusion: The present study found that mean cIMT in cases was more than controls. There is an additional effect of Diabetes on cIMT in hypertensive patient. Age and duration of disease can accelerate atherosclerosis.

Background & Objectives: Mesio-distal tooth size-arch length discrepancy is one of the major sources of malocclusion. Accurate prediction of space required for unerupted tooth can help in early interception of developing malocclusion. Various methods has been proposed for prediction of mesio-distal tooth size however accuracy of such methods in population groups other than that on which these methods are based remains questionable. The aims and objectives of this study were to test the reliability of Moyer’s and Tanaka Johnston mixed dentition analysis in Nepalese population, to construct prediction tables for Nepalese population if these methods were found not reliable.Materials & Methods: Study models of 77 subjects (31 males,46 females) fulfilling the inclusion criteria were retrieved from department archive. Tooth dimensions were measured using electronic digital caliper. Moyer’s and Tanaka and Jhonston methods were applied to predict the mesio- distal tooth size of canines and premolars. The predicted values were compared with the actual mesio-distal mesio-distal size. A regression equation based on actual canine and premolar mesio-distal dimensions and sum of mandibular permanent incisors was also developed.Results: Independent t-test showed that there was no significant difference between mesio-distal tooth size in males and females. Paired t-test showed that there was no difference in mesio-distal tooth size between right and left sides of the arch. Tanaka – Johnston analysis overestimated the mesio-distal size in both males and females. Moyer’s method at 75% overestimated the mesio-distal size in male and female and the difference were statistically significant while at 50% it underestimated the tooth size in females.Conclusion: Moyer’s and Tanaka and Jhonston method of mesio-distal size prediction are inaccurate when applied in Nepalese population. A new regression equation to predict the size of tooth has been presented.

CORRECTION: The conclusion on the PDF of this article was replaced on 17th April 2016. The corrected PDF is now available by clicking on the link below.Background & Objectives: Ectopic Left ventricular diastolic dysfunction is now well established as a cause of left sided heart failure and as a powerful predictor of cardiovascular events. It is attributed mostly to systemic hypertension. The objective of the study was to determine the prevalence of left ventricular diastolic dysfunction in recently diagnosed hypertensives in Nepalese population using echocardiography. Materials & Methods: Two-dimensional echocardiography was performed on 120 newly diagnosed patients of systemic hypertension. Transmitral Doppler indexes of diastolic function, Valsalva maneuver applied to the same mitral inflow pattern, pulsed tissue Doppler of the mitral annulus, deceleration time, isovolumic relaxation time and pulmonary venous flow pattern.Results: The age of the patients in our study ranged from 20 to 84 years with mean age of 50years±14.13 years (standard deviation) and male:female ratio being 1.35:1. Hypertensive patients were highest in age group 45-64 years followed by 25-44 years in both the genders. Majority of the patients had stage 1 hypertension (44.16%) followed by stage 2 HTN in 34.17% and pre-hypertension in 21.67%. The majority of the patients in our study had Grade 1 LVDD (66.67%), 10.83% patients had Grade II LVDD, only 2.50% had non-restrictive Grade III LVDD and none had LVDD-IV. Stage II hypertensives had more LVDD(I+II+III): 39/41-95.12% than stage I hypertensives(39/53-73.58%) and pre-hypertensives (8/26-30.77%). The association between stages of systemic HTN and LVDD was found to be highly statistically significant (p=0.002). Conclusion: Our study showed that left ventricular diastolic dysfunction is a common entity in Nepalese population with systemic hypertension.JCMS Nepal. 2016;12(1):14-18.

Background & Objectives:Sarcoidosis is a multi-system granulomatous disorder of unknown origin.The frequency and the clinical presentation of sarcoidosis vary among the geographical regions. This study is a retrospective analysis of the sarcoidosis patients diagnosed in Nepalese population. The aim of this study was to find the prevalence of sarcoidosis in Nepalese population which has high prevalence of tuberculosis and to understand the clinical profiles and ethnic differences.Materials & Methods:A retrospective chart analysis was done in all the patients from January first, 2005 to December 31st, 2010 who had abnormal chest radiograph and who were diagnosed with sarcoidosis. The study was done at Nepal Medical College Teaching Hospital and Everest Nursing Home.Results:A Forty two patients were diagnosed to have sarcoidosis over a five year period, of which 23/42 (55.0%) were females and 19/42 (45%) were males. The mean age was 36 years with minimum age being 18 years and maximum 72 years. As far as Ethnicity is concerned, 15/42 (36.0%)were Brahmins,08/42(19.0%) were Marwadi, and 07/42(17.0%) were Chhetri. The most common presenting symptom was cough 19/42 (45.0%).Out of the 42 patients, eight were being treated for pulmonary tuberculosis. Most common radiographic findings were bilateral hilar lymphadenopathy 15/42 (36.0%).Conclusion:Sarcoidosis is common in Nepal and should be considered in the differential diagnosis before treating the patient empirically for tuberculosis.