Search

Bhumi Chaturvedi,1 Sourav Debnath,1 Hemant Bareth,1 Preeti Raj,2 Pratima Singh,3 Mahaveer Singh,4 Deepak Nathiya,1,5,6 Balvir Singh Tomar5– 7 1Department of Pharmacy Practice, National Institute of Medical Sciences and Research, Jaipur, Rajasthan, India; 2School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; 3Public Health and Preventive Medicine, University of Alberta, Edmonton, AB, Canada; 4Department of Endocrinology, National Institute of Medical Sciences and Research, Jaipur, Rajasthan, India; 5Department of Clinical Studies, Fourth Hospital of Yulin (Xingyuan), Yulin, Shaanxi, People’s Republic of China; 6Department of Clinical Sciences, Shenmu Hospital, Shenmu, Shaanxi, People’s Republic of China; 7Institute of Pediatric Gastroenterology and Hepatology, National Institute of Medical Sciences and Research, Jaipur, Rajasthan, IndiaCorrespondence: Mahaveer Singh, Department of Endocrinology, National Institute of Medical Sciences and Research, Nims University, Jaipur, Rajasthan, India, Email drms.mamcmed@gmail.comIntroduction: The ongoing repercussions of the COVID-19 pandemic include potentially deleterious impacts on bone health.Aim: This research aimed to ascertain the effects of COVID-19 on the bone health of obese and non-obese Indian individuals.Methods: We executed a case-control study enrolling individuals who recovered from COVID-19. Participants were stratified into obese and non-obese groups based on their BMI. Comprehensive assessments encompassed anthropometric evaluations, laboratory tests, and bone mineral density (BMD) measurements using dual-energy X-ray absorptiometry (DEXA).Results: From April to July 2022, we enrolled obese (n = 27, mean BMI = 30.54 ± 4.51 kg/m 2) and non-obese (n = 23, mean BMI = 21.97 ± 2.20 kg/m 2) individuals. The cohort’s average age was 36.08 ± 15.81 years, with a male-to-female ratio of 1.6:1. There was a difference in BMD, especially at the total hip, between the two groups. BMD at the spine (L1-L4), the neck of the femur, and ultra-distal radius were consistent across both groups. Weight exhibited a significant positive correlation with BMD at L1-L4 (r = 0.40, p = 0.003) and the left femur total (r = 0.27, p = 0.001). Haemoglobin levels were lower in the obese group compared to their non-obese counterparts (12.3 ± 2.0 vs 13.6 ± 1.9, p = 0.01). Multivariate analysis underscored weight as a crucial predictor for BMD at the spine (L1-L4, p = 0.003) and total hip (p = 0.001).Conclusion: Even with advanced age, obese post-COVID-19 individuals demonstrate a higher bone mineral density (BMD) at the hip than non-obese subjects.Keywords: COVID-19, obesity, bone mineral density, osteopenia, fracture risk

Balvir S Tomar,1 Mahaveer Singh,2 Deepak Nathiya,3 Abhishek Sharma,4 Eshan Sharma,4 Hemant Bareth,3 Supriya Suman,3 Darshan Purshotambhai Ruparelia,4 Jaykumar Bharatbhai Patel,4 Vikrant Kantilal Gajera4 On Behalf of the NIMS COVID 19 Investigator Group1Institute of Gastroenterology, Hepatology & Transplant, Nims University Rajasthan, Jaipur, India; 2Department of Endocrinology, National Institute of Medical Sciences and Research Hospital, Nims University Rajasthan, Jaipur, 303121, India; 3Department of Pharmacy Practice, Institute of Pharmacy, Nims University Rajasthan, Jaipur, India; 4Department of General Medicine, National Institute of Medical Sciences and Research Hospital, Nims University Rajasthan, Jaipur, IndiaCorrespondence: Mahaveer SinghDepartment of Endocrinology, National Institute of Medical Sciences and Research Hospital, Nims University Rajasthan, Jaipur, 303121, IndiaTel +91 8949836075Email drms.mamcmed@gmail.comDeepak NathiyaDepartment of Pharmacy Practice, Institute of Pharmacy, Nims University Rajasthan, Jaipur, 303121, IndiaTel +91 9929600137Email dnathiya@nimsuniversity.orgPurpose: To assess the prevalence of post-COVID symptoms in patients with recovered COVID-19 (nasopharyngeal RT PCR negative) who were discharged from an acute COVID care facility at a tertiary care teaching hospital in North India.Methods: This study was an observational study with retrospective data collection, conducted in the COVID follow-up clinic, a combined clinic of medicine and endocrinology. Patients discharged from the acute COVID care facility were recruited after 14 days of discharge if they fulfilled inclusion and exclusion criteria. The retrospective data was collected from the hospital records/EMR and analysed by the SPSSv23.Results: Fifty patients, who fulfilled the inclusion and exclusion criteria, were included in the study. The Mean age of patients was 53.4± 13.8 years (range 28– 77). Seventy six percent were male, and 38% had type 2 diabetes. Fever (94%), cough (78%) and breathlessness (68%), were the most common symptoms at presentation to acute care facility. Oxygen saturation at presentation had a negative correlation with D-Dimer, age, and C reactive protein. When patients were evaluated clinically, after 14 days (range 15 to 50 days) of the discharge, 82% of patients had at least one persistent symptom. Fatigue (74%) was the most common symptoms in follow-up followed by breathlessness (44%), and muscle weakness (36%). Two patients had persistent fever, even after negative RT PCR status.Conclusion: Patients discharged from the acute COVID care facility had a high prevalence of post-COVID symptoms even after 14 days.Keywords: COVID-19, diabetes, SARS-CoV-2, oxygen saturation, post-COVID