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Manjri Singh,1 Parul Gupta,2 Richa Baronia,1 Priti Singh,1 Stalin Karuppiah,1 Rishi Shankar,3 Premendra D Dwivedi,2 Surinder P Singh1 1CSIR-National Physical Laboratory, New Delhi, 2CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO–DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO–DOx drug conjugate for head and neck cancer. Keywords: graphene oxide, doxorubicin, nanomedicine, head and neck cancer

Rajni Singh,1 Mony Sreedharan Smitha,1 Stalin Karuppiah,2 Surinder P Singh2 1Amity Institute of Microbial Biotechnology, Amity University, Noida, Uttar Pradesh, 2CSIR-National Physical Laboratory, New Delhi, Delhi, India Abstract: GO with –OH, –CHO, –CO, –COOH, and epoxide groups is considered more suitable than other commonly used materials for biomedical applications. The presence of –CO, –CHO, and –OH groups renders the easy functionalization of GO by biomolecules and drugs. Therefore, in this study, we designed a multifunctional GO–Fe3O4 nanocomposite and investigated its bactericidal activity against different bacterial strains with an evaluation of percentage inhibition. Our results revealed the potential of GO–Fe3O4 nanocomposites as an effective bactericidal, which can be used for dynamic applications in medical devices and food and other industries. Keywords: graphene oxide, GO nanocomposites, GO–Fe3O4, pathogenic strains, antibacterial

Richa Baronia,1 Manjri Singh,1 Rajat B Gupta,1 Stalin Karuppiah,1 Rajiv Kumar,2 Jodi Belz,2 Rishi Shanker,3 Srinivas Sridhar,2 Surinder P Singh1 1CSIR-National Physical Laboratory, Dr KS Krishnan Marg, New Delhi, India; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, India Abstract: Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines. Keywords: gold nanoclusters, radiation therapy