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Paragangliomas are rare tumors arising from undifferentiated cells of the primitive neural crest. We report a case of a 33-year-old female patient who presented a large firm retroperitoneal tumor situated on the left flank above the left kidney. Levels of the serum epinephrine and norepinephrine were high. We performed a scanned biopsy; the histopathological examination and the immunohistochemical analyses concluded the diagnosis of a retroperitoneal paraganglioma. The tumor was judged secreting and inoperable; therefore it was decided to be treated with radiotherapy., Paragangliomalar, ilkel nöral krest'in farklılaşmamış hücrelerinden kaynaklanan nadir tümörlerdir. Sol böbreğin sol böbrek üzerinde yer alan geniş retroperitonal tümör hastası olan 33 yaşında bir kadın hastayı sunduk. Serum epinefrin ve norepinefrin düzeyleri yüksek bulundu. Taranmış bir biyopsi yaptık; Histopatolojik inceleme ve immunohistokimyasal analizler retroperitoneal paraganglioma tanısını koydu. Tümör salgılanıp inoperabl olarak değerlendirildi; Bu nedenle radyoterapi ile tedavi edilmeye karar verildi.

Aim: Endometrial cancer is the most common gynecological cancer in the West. It is the third cancer of women after that of the breast and intestine. It mainly concerns menopausal women. Our aim is to highlight, through a retrospective study and in light of literature data, the role of radiotherapy in the management of this cancer.Methods: This is a retrospective cohort study concerning patients' records for endometrial in the radiotherapy department at university hospital center of FEZ for a period of 5 years from January 2012 to December 2016.Results: We collected 158 patients of mean age 64 years (36 to 92 years), all patients had a total hysterectomy with (76% of cases) or without (24% of cases) ganglion dissection. Type 1 was the most common histological type (96% of cases). The myometrial invasion was greater than 50% in 51% of cases, histological grade III in 36% of cases, and cervical invasion was observed in 16% of cases. Therapeutically, 18% of patients received exclusive external radiotherapy at a dose of 50 Gy in conventional fractionation and spreading, a TEN at a dose of 46 Gy followed by a brachytherapy dam in 58% of cases, and 24% of patients received brachytherapy alone.After an average follow-up of 25 months, 91% of the patients are in good locoregional control, 9% of the patients had distant metastases.Conclusion: Radiotherapy retains an important place in the therapeutic strategy of high endometrial cancers, or with unfavorable histological characters, and thus allows the reduction of locoregional recurrence rates.

The extraskeletal myxoid chondrosarcoma (CME) is a rare malignant soft tissue tumour described as a distinct clinical, histological, immunohistochemical, genetical and evolutive entity. It represents only 2.5% of soft tissue sarcomas. Its individualization is important because it has a long and indolent clinical course, and tumour-related death often occurs after a long survival period. The diagnostic key is morphological supported by immunohistochemistry and genetics t (9; 22) that allow differentiating it from other tumours with myxoid stroma and from chordoma. This report describes a patient with paravertebral extraskeletal myxoid chondrosrcoma with a high locoregional extension.