16 results on '"Yan, Sheng-Li"'
Search Results
2. Pure laparoscopic radical nephrectomy and inferior vena caval tumor thrombus removal in patients with complicated renal tumor
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Xin Zhang, Yan-Sheng Li, Bo Xiao, Tao Li, Peng Zhang, Yuan-Hao Chen, Xu-Hui Zhu, Xiu-Wu Han, and Ning-Ning Wang
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Medicine - Published
- 2019
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3. Clinical Observation of UreTron Single-Probe Ultrasonic Intracorporeal Lithotripter for Ureteral Calculi
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Yan-Sheng Li, Xin Zhang, Peng Zhang, Xu-Hui Zhu, Gao Li, Yuan-Hao Chen, Tao Li, and Xiu-Wu Han
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medicine.medical_specialty ,ureteral calculi ,Stone clearance ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,holmium laser ,Statistical difference ,Holmium laser ,International Journal of General Medicine ,General Medicine ,Lithotripsy ,lithotripsy ,Surgery ,medicine ,Ureteroscopic lithotripsy ,Single probe ,business ,Hospital stay ,Original Research ,UreTron - Abstract
Peng Zhang, Xiu-Wu Han, Xin Zhang, Xu-Hui Zhu, Tao Li, Yan-Sheng Li, Yuan-Hao Chen, Gao Li Department of Urology, Beijing Chao-Yang Hospital, Beijing, Peopleâs Republic of ChinaCorrespondence: Xiu-Wu HanDepartment of Urology, Beijing Chao-Yang Hospital, Capital Medical University, 5 Jingyuan Road, Shijingshan District, Beijing, Peopleâs Republic of ChinaTel +86 10-13501356960Email hanxiuwu47859@163.comObjective: The present study aimed to observe and discuss the effectiveness and safety of the UreTron single-probe ultrasonic intracorporeal lithotripter in ureteroscopic lithotripsy.Methods: The clinical data of patients with unilateral solitary ureteral calculi treated with ureteroscopic lithotripsy who were hospitalized at the Department of Urology (West District) of Beijing Chaoyang Hospital between March 2016 and August 2020 were selected for retrospective analysis. The patients were divided into the UreTron group (group U) and holmium laser group (group H) according to the lithotripsy method adopted. The operation duration, length of hospital stay, stone clearance rate, proportion of patients requiring flexible ureteroscopy-assisted lithotripsy, and complications were compared between the groups.Results: There was no statistical difference between the groups in terms of the general characteristics, operation duration, or length of hospital stay (P > 0.05). Regarding the stone clearance rate (group U=93.5%; group H=75%), proportion of patients requiring flexible ureteroscopy-assisted lithotripsy (group U=6.5%; group H=27.8%), and incidence of surgical complications (group U=1 case; group H=9 cases), group U was superior to group H, and the differences between the groups were statistically significant (P < 0.05). However, the differences in other complications (cardiocerebral complications and lower extremity thrombosis) were not statistically significant between the groups (P > 0.05).Conclusion: The UreTron system is a new lithotripsy apparatus that is safe and effective for ureteroscopic lithotripsy and has certain advantages in terms of the stone clearance rate, proportion of patients requiring flexible ureteroscopy-assisted lithotripsy, and surgical complications, making it worthy of clinical application.Keywords: UreTron, holmium laser, ureteral calculi, lithotripsy
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- 2021
4. A controlled clinical study of a two-trocar mini-laparoscopic technique versus the standard laparoscopic technique in treatment of adult renal cysts
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Yuan-Hao Chen, Gao Li, Siyuan Wang, Xuhui Zhu, Xiuwu Han, Xin Zhang, Yan-Sheng Li, and Peng Zhang
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Original Paper ,medicine.medical_specialty ,business.industry ,Urology ,renal cyst decortication ,Gastroenterology ,Obstetrics and Gynecology ,two-trocar approach ,Surgery ,renal cyst ,Clinical study ,Renal cysts ,medicine ,mini-laparoscopic surgery ,business - Abstract
Introduction Laparoscopic renal cyst decortication is currently the best choice for the treatment of simple renal cysts and is widely used in clinical practice Aim To investigate the safety and clinical efficacy of two-trocar mini-laparoscopic decortication of adult renal cysts. Material and methods A total of 90 patients were enrolled in the study and randomly divided into two groups: a two-trocar mini-laparoscopic treatment group (M group) and a three-trocar standard laparoscopic treatment group (S group), with 45 patients in each group. Results The average length of hospital stay was shorter, and the demand for postoperative analgesics was less in the M group than in the S group (p < 0.05). The proportion of “very satisfied” patients in the patient physical recovery satisfaction survey was significantly higher in the M group than in the S group (p < 0.05). Of the 45 patients in the M group, 40 successfully underwent surgery. In 3 patients, the two-trocar procedure was converted to a three-trocar procedure due to difficulty in separating perirenal adhesion for visualization. Mini-laparoscopic surgery was converted to classic laparoscopic surgery in 2 patients. In the S group, 44 patients successfully underwent the renal cyst decortication procedure. One patient underwent partial renal resection due to an intraoperative diagnosis of multilocular cystic renal cell carcinoma. Postoperative urine leakage was reported in 3 patients in the M group and two in the S group. Conclusions Two-trocar mini-laparoscopic treatment of renal cysts is as safe and effective as traditional laparoscopy but is associated with less cosmetic damage, leading to a better physical appearance.
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- 2021
5. Deep microbleeds and periventricular white matter disintegrity are independent predictors of attention/executive dysfunction in non-dementia patients with small vessel disease
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Ye Deng, Qun Xu, Quan Dong, Xue Chen, Wenwei Cao, Yan Zhou, Yao Wang, Yan-Sheng Li, and Li Gao
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Male ,China ,medicine.medical_specialty ,Population ,Neuropsychological Tests ,030204 cardiovascular system & hematology ,Cohort Studies ,Executive Function ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Dementia ,Attention ,Cognitive Dysfunction ,Neuropsychological assessment ,Cognitive decline ,Psychiatry ,education ,Depression (differential diagnoses) ,Aged ,Cerebral Hemorrhage ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Cognition ,Middle Aged ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,White Matter ,Psychiatry and Mental health ,Clinical Psychology ,Diffusion Tensor Imaging ,Cerebral Small Vessel Diseases ,Multivariate Analysis ,Cardiology ,Regression Analysis ,Female ,Geriatrics and Gerontology ,business ,Gerontology ,030217 neurology & neurosurgery ,Executive dysfunction ,Diffusion MRI - Abstract
Background:Cerebral small vessel disease (SVD) is the common cause of cognitive decline in the old population. MRI can be used to clarify its mechanisms. However, the surrogate markers of MRI for early cognitive impairment in SVD remain uncertain to date. We investigated the cognitive impacts of cerebral microbleeds (CMBs), diffusion tensor imaging (DTI), and brain volumetric measurements in a cohort of post-stroke non-dementia SVD patients.Methods:Fifty five non-dementia SVD patients were consecutively recruited and categorized into two groups as no cognitive impairment (NCI) (n = 23) or vascular mild cognitive impairment (VaMCI) (n = 32). Detailed neuropsychological assessment and multimodal MRI were completed.Results:The two groups differed significantly on Z scores of all cognitive domains (all p < 0.01) except for the language. There were more patients with hypertension (p = 0.038) or depression (p = 0.019) in the VaMCI than those in the NCI group. Multiple regression analysis of cognition showed periventricular mean diffusivity (MD) (β = −0.457, p < 0.01) and deep CMBs numbers (β = −0.352, p < 0.01) as the predictors of attention/executive function, which explained 45.2% of the total variance. Periventricular MD was the independent predictor for either memory (β = −0.314, p < 0.05) or visuo-spatial function (β = −0.375, p < 0.01); however, only small proportion of variance could be accounted for (9.8% and 12.4%, respectively). Language was not found to be correlated with any of the MRI parameters. No correlation was found between brain atrophic indices and any of the cognitive measures.Conclusion:Arteriosclerotic CMBs and periventricular white matter disintegrity seem to be independent MRI surrogated markers in the early stage of cognitive impairment in SVD.
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- 2016
6. Early Use of Statin in Patients Treated with Alteplase for Acute Ischemic Stroke
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Lin Yu, Zhihao Mu, Yan-Sheng Li, Yeping Song, Qun Xu, Guo-Wen Shi, Guo-Yuan Yang, Ya-meng Sun, Yan Lin, Yuanmei Pan, Jieli Geng, and Ying Chen
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Intracerebral hemorrhage ,medicine.medical_specialty ,Statin ,medicine.drug_class ,business.industry ,Incidence (epidemiology) ,medicine.medical_treatment ,Thrombolysis ,030204 cardiovascular system & hematology ,Logistic regression ,medicine.disease ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Physical therapy ,Cardiology ,cardiovascular diseases ,Stage (cooking) ,business ,Stroke ,030217 neurology & neurosurgery - Abstract
Studies have reported that statin usage before stroke can increase the incidence of intracerebral hemorrhage after thrombolytic treatment. However, whether the administration of statin at an early stage of ischemic stroke increases hemorrhage occurrence is unknown. The aim of this study was to assess the effect of statin on neurological imaging and functional outcomes after intravenous alteplase treatment, within 24 h of acute ischemic stroke attack. A total of 119 consecutive acute ischemic stroke patients treated by intravenous alteplase were recruited, of which 71 patients (59.7 %) were given statin therapy within 24 h of stroke onset. The physiological parameters, including demography, vascular risk factors, and clinical characteristics were recorded. The occurrence of intracerebral hemorrhage (ICH), symptomatic intracerebral hemorrhage (sICH), 90-day functional outcomes, and mortality in the patients were further analyzed. There were 24 occurrences of ICH after alteplase treatment (20.2 %) and there was no difference when patients were treated with statin (p = 0.280). Multivariate logistic regression analysis showed no significant correlation between the administration of statin and the occurrence of ICH (p = 0.230) or sICH (p = 0.949). There was a trend toward better neurological function with higher statin dose. The use of statin in the early stage of ischemic stroke is safe and does not increase the risk of intracerebral hemorrhage after alteplase treatment, suggesting that a clinical trial of early statin treatment on a large scale following thrombolysis is needed for further evaluation.
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- 2016
7. Molecular epidemiology of PRRSV from China’s Guangxi Province between 2007 and 2009
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Lin-Juan Xie, Ting Rong Luo, Xiao-ning Li, Hui Li, Jing-Jing Liang, Xian-Ming Meng, Shan Yin, Li-Juan Su, Jian Yang, Yan-Sheng Li, Xiao-Xia He, Hong-Pu Zhang, Hong-Yun Zhang, and Xiao-Quan Li
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China ,medicine.medical_specialty ,Genotype ,Swine ,viruses ,Molecular Sequence Data ,Porcine Reproductive and Respiratory Syndrome ,Biology ,Genome ,Viral Proteins ,Medical microbiology ,Virology ,Genetics ,medicine ,Animals ,Cluster Analysis ,Porcine respiratory and reproductive syndrome virus ,Molecular Biology ,Gene ,Phylogeny ,Sequence Deletion ,chemistry.chemical_classification ,Molecular Epidemiology ,Polymorphism, Genetic ,Molecular epidemiology ,Phylogenetic tree ,virus diseases ,RNA ,Sequence Analysis, DNA ,General Medicine ,Amino acid ,chemistry ,RNA, Viral ,Gene sequence - Abstract
Porcine reproductive and respiratory syndrome (PRRS) is considered to be one of the most important infectious diseases affecting livestock. This study used gene sequence analysis of ORF5 and Nsp2 to determine the molecular epidemiology of PRRSV in different parts of the Guangxi province of China. These genes were selected due to their extensive variation within the genome. Out of 189 samples from animals suspected to have PRRS, 145 were PRRSV RNA positive. ORF5 and Nsp2 gene sequence analysis of 31 of these samples showed that all of the Guangxi isolates were of type 2. A phylogenetic tree analysis based on ORF5 showed that the Guangxi isolates were divided into two groups. Most of these were closely related to highly pathogenic strains, showing a 30 amino acid deletion at positions 481 and 533-561 of Nsp2, but an additional unique isolate (GXNN06) possessed a further four amino acid deletion at positions 485-488 of Nsp2.
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- 2012
8. A digital model individual template and CT-guided 125I seed implants for malignant tumors of the head and neck
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Guang-Yan Yu, Yan-Sheng Li, Yan Shi, Jian-Guo Zhang, Lei Zheng, Shu-Ming Liu, Ming-Wei Huang, and Jie Zhang
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Adult ,Male ,medicine.medical_specialty ,Technology ,Adolescent ,Radioactive seed ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Brachytherapy ,Digital model ,Models, Biological ,head and neck ,Iodine Radioisotopes ,Young Adult ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Computer Simulation ,Radiation treatment planning ,Head and neck ,Child ,Aged ,Prior Surgery ,Radiation ,business.industry ,125i seed ,Middle Aged ,Radiation therapy ,Clinical Practice ,Treatment Outcome ,radioactive seeds ,Head and Neck Neoplasms ,Child, Preschool ,Radiographic Image Interpretation, Computer-Assisted ,Female ,Radiology ,Radiopharmaceuticals ,Nuclear medicine ,business ,individual template ,Radiotherapy, Image-Guided - Abstract
To enhance the accuracy of radioactive seed implants in the head and neck, a digital model individual template, containing information simultaneously on needle pathway and facial features, was designed to guide implantation with CT imaging. Thirty-one patients with recurrent and local advanced malignant tumors of head and neck after prior surgery and radiotherapy were involved in this study. Before (125)I implants, patients received CT scans based on 0.75mm thickness. And the brachytherapy treatment planning system (BTPS) software was used to make the implantation plan based on the CT images. Mimics software and Geomagic software were used to read the data containing CT images and implantation plan, and to design the individual template. Then the individual template containing the information of needle pathway and face features simultaneously was made through rapid prototyping (RP) technique. All patients received (125)I seeds interstitial implantation under the guide of the individual template and CT. The individual templates were positioned easily and accurately, and were stable. After implants, treatment quality evaluation was made by CT and TPS. The seeds and dosages distribution (D(90),V(100),V(150)) were well meet the treatment requirement. Clinical practice confirms that this approach can facilitate easier and more accurate implantation.
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- 2012
9. Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to Alzheimer's disease
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Min-Yue Zhang, Yan-Sheng Li, Ling Miao, and Guang-Yuan Hu
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Male ,medicine.medical_specialty ,Genotype ,Polymorphism, Single Nucleotide ,Gastroenterology ,White People ,Gene Frequency ,Meta-Analysis as Topic ,Alzheimer Disease ,Polymorphism (computer science) ,Internal medicine ,Confidence Intervals ,Odds Ratio ,medicine ,Humans ,Age of Onset ,Allele ,Risk factor ,Allele frequency ,Methylenetetrahydrofolate Reductase (NADPH2) ,Aged ,Genetics ,biology ,Asia, Eastern ,business.industry ,General Neuroscience ,Case-control study ,General Medicine ,Odds ratio ,Case-Control Studies ,Methylenetetrahydrofolate reductase ,biology.protein ,Female ,business ,Publication Bias - Abstract
No clear consensus has been reached at the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and Alzheimer's disease (AD) risk. Thus in this meta-analysis, a total of 19 case-control studies was assessed to evaluate the possible association. The data demonstrated that the frequency of T677 allele (T vs. C) was significantly associated with susceptibility to AD in all subjects (OR=1.15, 95% CI=1.06-1.26) and in East Asians (OR=1.22, 95% CI=1.08-1.39). There was statistical difference between AD patients and the controls under recessive genetic mode (CT+TT vs. CC) and homozygote comparison (TT vs. CC) in all subjects and in East Asians as well. Despite a small effect of the polymorphism on late-onset AD (LOAD) risk, MTHFR C677T polymorphism was not a major risk factor for LOAD in East Asians and Caucasians. A subgroup analysis in the subjects without APOE epsilon4 alleles showed T677 allele significantly increased risk of AD in all subjects (OR=1.21, 95% CI: 1.04-1.42) and in East Asians (OR=1.28, 95% CI: 1.06-1.55). However, no association was found in Caucasians. In conclusion, this meta-analysis supports that MTHFR C677T polymorphism is capable of causing AD susceptibility in East Asians, not in Caucasians.
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- 2010
10. Brief screening for mild cognitive impairment in subcortical ischemic vascular disease: a comparison study of the Montreal Cognitive Assessment with the Mini-Mental State Examination
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Ling Yu, Yan Lin, Qun Xu, Jian-hua Mi, Wen-wei Cao, and Yan-Sheng Li
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Male ,medicine.medical_specialty ,Neuropsychological Tests ,Sensitivity and Specificity ,Brain Ischemia ,Internal medicine ,medicine ,Raw score ,Humans ,Cognitive Dysfunction ,Psychiatry ,Vascular dementia ,Cognitive impairment ,Aged ,Aged, 80 and over ,Mini–Mental State Examination ,Receiver operating characteristic ,medicine.diagnostic_test ,Vascular disease ,Montreal Cognitive Assessment ,Middle Aged ,medicine.disease ,Neurology ,ROC Curve ,Area Under Curve ,Comparison study ,Female ,Neurology (clinical) ,Psychology - Abstract
Background and Purpose: To assess the validity of the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) in the detection of vascular mild cognitive impairment (VaMCI) in patients with subcortical ischemic vascular disease (SIVD). Methods: Among 102 SIVD patients, both cutoff scores of the MMSE and MoCA for differentiating VaMCI from no cognitive impairment (NCI) or differentiating VaMCI from vascular dementia (VaD) were determined by the receiver operator characteristic (ROC) analysis. Optimal sensitivity with specificity of cutoff scores was obtained after the raw scores were adjusted for education. Results: After adjusting for education, the MoCA cutoff score for differentiating VaMCI from NCI was at 24/25 and that for differentiating VaMCI from VaD was at 18/19. After applying the adjusted MoCA scores from 19 to 24 to identify VaMCI in all SIVD patients, sensitivity was at 76.7% and specificity was at 81.4% (κ = 0.579). The adjusted cutoff score of the MMSE for differentiating VaMCI from NCI was at 28/29 and that for differentiating VaMCI from VaD was at 25/26. The sensitivity and specificity of the adjusted MMSE was at 58.1 and 71.2%, respectively, when using the score from 26 to 28 to identify VaMCI in SIVD patients (κ = 0.294). Conclusions: The MoCA detected subcortical VaMCI better than the MMSE.
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- 2013
11. Age- and Gender-Specific Prevalence of Risk Factors in Patients with First-Ever Ischemic Stroke in China
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Yan-Sheng Li, Guo-Wen Shi, Ya-meng Sun, Qun Xu, Yan Lin, Ying Chen, Xiao-ying Yao, and Jieli Geng
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Pediatrics ,medicine.medical_specialty ,Article Subject ,business.industry ,Atrial fibrillation ,Vascular risk ,medicine.disease ,Age and gender ,Diabetes mellitus ,Ischemic stroke ,medicine ,In patient ,Neurology (clinical) ,Neurology. Diseases of the nervous system ,Family history ,Young adult ,business ,RC346-429 ,Research Article - Abstract
Background. Evidences are accumulating that age and gender have great impact on the distribution of stroke risk factors. Such data are lacking in Chinese population.Methods. 1027 patients with first-ever ischemic stroke (IS) were recruited and divided into young adult (80 years) groups according to stroke onset ages. Vascular risk factors were collected and compared among groups.Results. Female patients were globally older than male patients at stroke onset and having higher prevalence of diabetes mellitus (DM), heart diseases, and atrial fibrillation (AF). However, females were less likely to drink heavily or smoke than males. Young patients had a much higher proportion of smoking and drinking than middle-aged and very old patients and the highest family history of hypertension, while very old patients had the highest prevalence of heart diseases and AF but lowest proportion of positive family history of vascular diseases. Hypertension and DM were equally frequent among three groups.Conclusion. Our study showed that vascular risk factors had a specific age and gender distribution pattern in Chinese IS patients. Secondary prevention strategy should emphasize on the control of different risk factors based on patient’s age and gender.
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- 2012
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12. Diffusion tensor imaging changes correlate with cognition better than conventional MRI findings in patients with subcortical ischemic vascular disease
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Wen-wei Cao, Yan-Sheng Li, Qun Xu, Sheng-Di Chen, Yan Lin, Yuanmei Pan, and Yan Zhou
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Male ,medicine.medical_specialty ,Pathology ,Cognitive Neuroscience ,White matter ,Executive Function ,Cognition ,Internal medicine ,Fractional anisotropy ,medicine ,Dementia ,Humans ,Attention ,Neuropsychological assessment ,Vascular dementia ,Aged ,Aged, 80 and over ,Analysis of Variance ,medicine.diagnostic_test ,Dementia, Vascular ,Cognitive disorder ,Brain ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Radiography ,Psychiatry and Mental health ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,Case-Control Studies ,Mental Recall ,Cardiology ,Female ,Geriatrics and Gerontology ,Psychology ,Cognition Disorders ,Diffusion MRI - Abstract
Background/Aims: To investigate whether diffusion tensor imaging (DTI) is more sensitive than conventional MRI at detecting cognitive deterioration in patients with subcortical ischemic vascular disease (SIVD). Methods: Forty-two SIVD patients had a diagnosis of no cognitive impairment (NCI), vascular cognitive impairment/no dementia or vascular dementia (VaD). Whole-brain DTI histography and routine MRI were performed on these participants. Results: There were significant differences between cognitively impaired patients and NCI subjects in mean diffusivity and fractional anisotropy in either whole-brain white matter (WBWM) or in normal-appearing white matter (NAWM). All DTI indices within either WBWM or NAWM were found to be significantly correlated with both the attention-executive and memory measures in SIVD subjects. Lacune numbers and T2-weighted lesions correlated only with attention-executive measures, whereas hippocampal volumes correlated only weakly with memory measures. Whole-brain gray matter volumes correlated with Z scores for all cognitive domains but language. After VaD patients had been excluded from the analysis, cognitive measures remained significantly correlated with some of the DTI indices, but not with conventional MRI findings. Conclusions: Compared with conventional MRI, whole-brain DTI is a more reliable and sensitive technique for the early detection of cognitive impairment in SIVD patients.
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- 2010
13. P1‐424: Diffusion tensor imaging correlates with cognition better than conventional MRI in patients with subcortical ischemic vascular disease
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Yan Lin, Qun Xu, Wenwei Cao, Yuanmei Pan, Yan-Sheng Li, Sheng-Di Chen, and Yan Zhou
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medicine.medical_specialty ,Epidemiology ,Vascular disease ,business.industry ,Health Policy ,Cognition ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,In patient ,Neurology (clinical) ,Radiology ,Geriatrics and Gerontology ,business ,Diffusion MRI - Published
- 2010
14. Whole brain diffusion tensor imaging histogram analysis in vascular cognitive impairment
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Jiong Zhu, Yan-sheng Li, Zhi-guo Zhuang, Jing Tao, Yan Zhou, Jianrong Xu, Li-jun Qian, Fuchun Lin, and Hao Lei
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Male ,Brain mapping ,Fractional anisotropy ,medicine ,Effective diffusion coefficient ,Humans ,Prospective Studies ,Vascular Diseases ,Prospective cohort study ,Stroke ,Aged ,Retrospective Studies ,Analysis of Variance ,Brain Mapping ,business.industry ,Cognitive disorder ,Brain ,equipment and supplies ,medicine.disease ,body regions ,Diffusion Magnetic Resonance Imaging ,nervous system ,Neurology ,Female ,sense organs ,Neurology (clinical) ,Analysis of variance ,Nuclear medicine ,business ,Psychology ,Cognition Disorders ,Neuroscience ,Diffusion MRI - Abstract
Background Studies were carried out to detect brain tissue damage in patients with vascular cognitive impairment (VCI) using diffusion tensor imaging (DTI) histogram analysis, and to determine the correlations between DTI histogram-derived measures and Mini-Mental State Examination (MMSE) scores. Methods Conventional MRI and DTI scans were performed on 19 patients with VCI, 19 age- and sex-matched post-stroke patients without cognitive impairment (stroke group) and 19 cognitively normal subjects (CN group). Histograms of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the whole brain were analyzed. Results Analysis showed that the patterns of the whole brain ADC and FA histograms of the VCI group differed from those of the stroke and CN groups. Compared with those of the two control groups, the mean FA value was significantly lower and the FA histogram peak height was higher in the VCI group. However, the patterns of the whole brain ADC and FA histograms in the stroke group were similar to those of the CN group, and there were no significant differences in any of the DTI histogram-derived measures between these two groups. The mean FA value, the FA histogram peak height, and the FA histogram peak location in VCI patients correlated with the MMSE scores. Conclusions Our findings suggest that VCI leads to abnormal diffusion in brain tissue, and that DTI histogram-derived measures might be used to monitor the severity of cognitive impairment in this disease.
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- 2007
15. Effect of endogenous estrogen on endothelial function in women with coronary heart disease and its mechanism
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Mei Gao, Yan Zhou, Shui-Ping Zhao, Yan-Sheng Li, Xiang Ping Li, and Qi-Chang Zhou
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medicine.medical_specialty ,Endothelium ,Brachial Artery ,medicine.drug_class ,Clinical Biochemistry ,Endogeny ,Vasodilation ,Coronary Disease ,Biochemistry ,chemistry.chemical_compound ,Internal medicine ,medicine ,Humans ,Endothelial dysfunction ,biology ,business.industry ,Biochemistry (medical) ,Estrogens ,General Medicine ,Middle Aged ,medicine.disease ,Nitric oxide synthase ,Blood pressure ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Estrogen ,biology.protein ,Female ,Endothelium, Vascular ,business ,Asymmetric dimethylarginine - Abstract
Background: Estrogen promotes and modulates vascular endothelial function, which may be protective against development of atherosclerosis. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, has been reported to be associated with the impairment of vascular endothelial function. Recent studies suggested estrogen replacement therapy lowers plasma concentrations of ADMA in healthy postmenopausal women. However, the relation between endogenous estrogen and ADMA and their effect on endothelial function in patients with coronary heart disease (CHD) remains unclear. Methods: Flow-mediated dilatation (FMD) and nitroglycerin-induced dilatation (NID) of the brachial arteries were detected by using high-resolution ultrasound in 33 women with CHD and 17 healthy controls. Plasma estradiol, ADMA, and lipid concentrations were also measured in all subjects. Results: In comparison with control group, FMD and NID were significantly decreased in the CHD group (1.73±1.26% vs. 5.37±3.20%, p
- Published
- 2003
16. In vitro infection with classical swine fever virus inhibits the transcription of immune response genes
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Yan-Sheng Li, Jun Li, Xiao-Quan Li, Shan Yin, Ting Rong Luo, Xian-Ming Meng, Xiao-ning Li, Li Feng, Shi-Kai Sun, Jing-Jing Liang, Xin-Bin Cai, Hui Li, Hong-Yun Zhang, and Li-Juan Su
- Subjects
Transcription, Genetic ,Swine ,medicine.medical_treatment ,Genes, MHC Class II ,Real-Time Polymerase Chain Reaction ,Immune response genes ,Virus ,Cell Line ,Immune tolerance ,lcsh:Infectious and parasitic diseases ,Classical swine fever virus (CSFV) ,Immune system ,Virology ,Immune Tolerance ,medicine ,Animals ,lcsh:RC109-216 ,Gene ,Immune Evasion ,biology ,Antigen processing ,Gene Expression Profiling ,Research ,fungi ,biology.organism_classification ,Real-time RT-PCR ,Chronic infection ,Cytokine ,Infectious Diseases ,Classical Swine Fever Virus ,Classical swine fever ,Host-Pathogen Interactions ,Immunology - Abstract
Background Classical swine fever virus (CSFV) can evade the immune response and establish chronic infection under natural and experimental conditions. Some genes related to antigen processing and presentation and to cytokine regulation are known to be involved in this response, but the precise mechanism through which each gene responds to CSFV infection remains unclear. Results In this study, the amplification standard curve and corresponding linear regression equations for the genes SLA-2, TAP1, SLA-DR, Ii, CD40, CD80, CD86, IFN-α, and IFN-β were established successfully. Real-time RT-PCR was used to quantify the immune response gene transcription in PK-15 cells post CSFV infection. Results showed that: (1) immune response genes were generally down-regulated as a result of CSFV infection, and (2) the expression of SLA-2, SLA-DR, Ii and CD80 was significantly decreased (p Conclusion We conclude that in vitro infection with CSFV inhibits the transcription of host immune response genes. These findings may facilitate the development of effective strategies for controlling CSF.
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