57 results on '"Xiuyu Chen"'
Search Results
2. Proton magnetic resonance spectroscopy ((1)H-MRS) reveals geniculocalcarine and striate area degeneration in primary glaucoma.
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Yan Zhang, Xiuyu Chen, Ge Wen, Guijun Wu, and Xuelin Zhang
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Medicine ,Science - Abstract
BACKGROUND: Glaucoma is a collection of neurodegenerative diseases that affect both the retina and the central visual pathway. We investigated whether metabolites' concentrations changed in the geniculocalcarine (GCT) and the striate area of occipital lobe by proton magnetic resonance spectroscopy ((1)H-MRS), suggesting neurodegeneration of the central visual pathway in primary glaucoma. METHODOLOGY/PRINCIPAL FINDINGS: 20 patients with glaucoma in both eyes were paired with 20 healthy volunteers in same gender and an age difference less than 3 years. All the participants were examined by MR imaging including T1 Flair, T2 FSE and (1)H-MRS. The T1 intensity and T2 intensity of their GCTs and striate areas were measured. The ratio of N-acetylaspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, glutamine and glutamate (Glx)/Cr were derived by multi-voxels (1)H-MRS in the GCT and the striate area of each brain hemisphere. The T1 intensity and T2 intensity had no difference between the groups. Significant decreases in NAA/Cr and Cho/Cr but no difference in Glx/Cr was found between the groups in both the GCT and the striate area. CONCLUSIONS/SIGNIFICANCE: Primary glaucoma affects metabolites' concentrations in the GCT and the striate area suggesting there is ongoing neurodegenerative process.
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- 2013
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3. Three-dimensional phase-sensitive inversion-recovery Turbo FLASH sequence for the assessment of left ventricular myocardial scar in swine.
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Xiuyu Chen, Minjie Lu, Gang Yin, Tao Zhao, Xiaoning Shao, Ranxu Zhao, Yue Tang, Jing An, Shiliang Jiang, and Shihua Zhao
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Medicine ,Science - Abstract
OBJECTIVES:We sought to evaluate the feasibility and accuracy of free-breathing three-dimensional (3D) phase-sensitive inversion-recovery (PSIR) Turbo FLASH sequence for noninvasive assessment of left ventricular myocardial scar in swine models. MATERIALS AND METHODS:Nine Chinese minipigs with experimentally induced acute myocardial infarction were studied. At 1 week and the study endpoint 4 weeks after myocardial infarction surgery, the 3D and 2D contrasted cardiac magnetic resonance (CMR) imaging were performed randomly by using a 1.5 T clinical MR imaging system. Comparisons of myocardial scar volume (in cubic centimeters), scar transmurality (on a 5 points scale) and image quality (on a 4 points Likert scale) were performed by using the Pearson correlation and Bland-Altman analysis (for myocardial scar volume) or κ statistics (for transmurality) or Wilcoxon signed rank test (for image quality). RESULTS:In 6 of the 9 pigs, all procedures were successfully completed. In these pigs, a total of 48 segments with myocardial scars were detected by both 3D and 2D sequences, and there was good agreement for classification of scar transmurality (κ=0.930). The scar volume determined by triphenyltetrazolium chloride (TTC) staining (3.52 ± 1.40 cm(3)) showed a good correlation with both 3D (3.54 ± 1.36 cm(3), r=0.957, P=0.003) and 2D sequence (3.53 ± 1.26 cm(3), r=0.942, P=0.005) at 4 weeks. And there were good correlation between scar volumes obtained from 3D and 2D techniques (r=0.859, P
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- 2013
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4. Correction: Three-Dimensional Phase-Sensitive Inversion-Recovery Turbo FLASH Sequence for the Assessment of Left Ventricular Myocardial Scar in Swine.
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Xiuyu Chen, Minjie Lu, Gang Yin, Tao Zhao, Xiaoning Shao, Ranxu Zhao, Yue Tang, Jing An, Shiliang Jiang, and Shihua Zhao
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Medicine ,Science - Published
- 2013
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5. Correlation between left ventricular fractal dimension and impaired strain assessed by cardiac MRI feature tracking in patients with left ventricular noncompaction and normal left ventricular ejection fraction
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Kai Yang, Jia-Xin Wang, Shiqin Yu, Shihua Zhao, Weipeng Yan, Guohai Su, Kankan Zhao, Wenhao Dong, and Xiuyu Chen
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medicine.medical_specialty ,Population ,Magnetic Resonance Imaging, Cine ,Ventricular Function, Left ,Contractility ,Ventricular Dysfunction, Left ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,education ,Retrospective Studies ,Neuroradiology ,education.field_of_study ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Stroke Volume ,Magnetic resonance imaging ,General Medicine ,Stroke volume ,Magnetic Resonance Imaging ,Fractals ,cardiovascular system ,Cardiology ,Left ventricular noncompaction ,Radiology ,business - Abstract
To investigate the correlation between the extent of excessive trabeculation assessed by fractal dimension (FD) and myocardial contractility assessed by cardiac MRI feature tracking in patients with left ventricular noncompaction (LVNC) and normal left ventricular ejection fraction (LVEF). Forty-one LVNC patients with normal LVEF (≥ 50%) and 41 healthy controls were retrospectively included. All patients fulfilled three available diagnostic criteria on MRI. Cardiac MRI feature tracking was performed on cine images to determine left ventricular (LV) peak strains in three directions: global radial strain (GRS), global circumferential strain (GCS), and global longitudinal strain (GLS). The complexity of excessive trabeculation was quantified by fractal analysis on short-axis cine stacks. Compared with controls, patients with LVNC had impaired GRS, GCS, and GLS (all p
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- 2021
6. Prognostic significance of myocardial fibrosis and CMR characteristics in bicuspid aortic valve with moderate and severe aortic insufficiency
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Kai Wang, Guohai Su, Shihua Zhao, Kai Yang, Yucong Zheng, Minjie Lu, Gang Yin, Rui Li, and Xiuyu Chen
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Adult ,Aortic valve ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Aortic Valve Insufficiency ,Population ,Contrast Media ,Gadolinium ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Bicuspid aortic valve ,Bicuspid Aortic Valve Disease ,Fibrosis ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Adverse effect ,education ,Retrospective Studies ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Aortic Valve Stenosis ,General Medicine ,Odds ratio ,Prognosis ,medicine.disease ,medicine.anatomical_structure ,Aortic Valve ,030220 oncology & carcinogenesis ,cardiovascular system ,Cardiology ,Myocardial fibrosis ,Radiology ,business - Abstract
This study attempted to evaluate the characteristics and prognostic value of myocardial fibrosis (MF) in aortic insufficiency (AI) patients with bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) by cardiac magnetic resonance (CMR). A total of 314 adults with CMR-diagnosed AI were retrospectively retrieved. Of them, 166 patients with moderate or severe AI were included and divided into two groups: BAV group (N = 46) and a TAV group (N = 120). The presence and characteristics of MF were assessed with CMR. The patients were followed for adverse clinical events. The prognostic capability of the parameters was assessed using Cox regression model. LV fibrosis was more common in the BAV group than in the TAV group (65.2% vs. 45.0%; p = 0.020). There was a strong association between BAV and MF even after adjusting for clinical and imaging variables (odds ratio: 3.57; p = 0.031). Kaplan-Meier analysis showed a higher rate of clinical adverse events in AI+BAV patients with MF during a median follow-up of 4.7 years. Multivariate Cox regression analysis showed that late gadolinium enhancement (LGE) was an independent predictor of clinical adverse outcome. MF is more common in AI with BAV than with TAV and is a predictor of clinical adverse events. • The presence and extent of late gadolinium enhancement of left ventricular were more common and severer in the bicuspid aortic valve group than in the tricuspid aortic valve group in aortic insufficiency patients. • Bicuspid aortic valve was an independent factor for myocardial fibrosis in aortic insufficiency patients. • Late gadolinium enhancement could be used as an independent predictor of adverse clinical events in this population.
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- 2021
7. Late gadolinium enhancement characteristics in giant cell myocarditis
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Jialin Song, Xiuyu Chen, Yang Sun, Hong-Yue Wang, Shihua Zhao, Shujuan Yang, and Jinghui Li
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medicine.medical_specialty ,Short Communication ,Short Communications ,Contrast Media ,Gadolinium ,030204 cardiovascular system & hematology ,Giant cell myocarditis ,Late gadolinium enhancement ,Giant Cells ,Both ventricles ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,In patient ,030212 general & internal medicine ,cardiovascular diseases ,Endocardium ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,GCM transcription factors ,medicine.disease ,Subendocardium ,Myocarditis ,RC666-701 ,Heart failure ,embryonic structures ,Cardiology ,Cardiovascular magnetic resonance ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims This study aims to demonstrate the characteristics of late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance (CMR) imaging in patients with giant cell myocarditis (GCM). Methods and results Six patients histologically diagnosed with GCM were retrospectively recruited in this study. All of them underwent CMR during hospitalization. The distribution and extent of LGE were assessed on both ventricles, and the AHA‐17 segment model was used for left ventricular (LV) analysis. Nine case reports with CMR in GCM were reviewed and summarized to investigate the features of LGE further. LGE was detected on both ventricular walls in all subjects. For a detailed analysis of LGE in the LV, the extent ranged from 21.6% to 56%. Among 70 segments (68.6%) involved by LGE, the subendocardial LGE was the most common pattern (46/102, including 24 segments located in the right‐sided septum), followed by the subepicardial pattern (23/102). The right‐sided septum, the subepicardial anterior wall, and the subendocardial right ventricular (RV) wall were observed in all subjects. To summarize the results of the present study with these case reports, the three most common patterns of LGE are the right‐sided septum (73%), the subepicardial anterior wall (60%), and the subendocardial RV wall (53%). Conclusions Extensive LGE seems to be common in GCM, affecting both LV and RV walls. Apart from subepicardial LGE, subendocardial LGE, which was used to be implicated in ischaemic disease, was frequently presented in GCM. The right‐sided subendocardial septum, the subepicardial anterior wall, and the subendocardial RV wall might be the vulnerable areas of LGE in GCM.
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- 2021
8. The Etiological Heterogeneity of Bicuspid Aortopathy between Ascending and Root Morphotype
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Gang Yin, Wei Wang, Cun-Tao Yu, Fei Li, Xuan Li, Yuetang Wang, Shihua Zhao, Xiuyu Chen, and Qi Gao
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Pathology ,medicine.medical_specialty ,biology ,business.industry ,Hemodynamics ,Context (language use) ,General Medicine ,Degeneration (medical) ,Matrix (biology) ,Matrix metalloproteinase ,medicine.anatomical_structure ,medicine.artery ,Ascending aorta ,cardiovascular system ,medicine ,biology.protein ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Elastin ,Elastic fiber - Abstract
Background: Valve-related hemodynamics and intrinsically regulated matrix proteases are 2 determined pathogenetic factors associated with medial elastin degeneration in bicuspid aortopathy. This study analyzed the association between elastic fiber deterioration and the 2 pathogenetic factors in ascending and root morphotypes, aiming to elucidate the etiological heterogeneity between the 2 morphotypes. Methods: Four-dimensional flow cardiac magnetic resonance was used to measure the regional wall shear stress (WSS) on the ascending aorta, and matrix metalloproteinase (MMP) expression was assessed by immunoblotting. After histopathology analysis of aortic tissue, we assessed whether elevated regional WSS and increased MMP expression corresponded with medial elastin thinning. Results: Increased regional WSS corresponded with medial elastin thinning in both morphotypes. Increased expression of different MMP isoforms corresponded with medial elastin degeneration in bicuspid aortopathy. The significantly increased expression of MMP-2 corresponded with a decrease of elastic fiber thickness in the ascending morphotype (P = .046), whereas elastic fiber thinning was associated with high levels of MMP-3 expression (P = .012) in the root morphotype. No association was observed between regional WSS and MMP expression. Conclusion: There is no difference in the effect of valve-related hemodynamics between ascending and root morphotype, and MMPs are not involved in the process of elastic fiber degeneration induced by increased WSS. The increased expression of different MMP isoforms was observed in the context of elastic fiber degeneration between the 2 morphotypes, implying that heterogeneity between them is revealed in the different intrinsic pathway of medial elastin degradation.
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- 2020
9. 3.0 T magnetic resonance imaging scanning on different body regions in patients with pacemakers
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Keping Chen, Zhimin Liu, Xiaohui Ning, Xiaofei Li, Shihua Zhao, Xiuyu Chen, Wei Hua, Xiaohan Fan, Yan Dai, Shu Zhang, and Minjie Lu
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Pacemaker, Artificial ,medicine.medical_specialty ,Image quality ,Heart Ventricles ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Cardiac pacemaker ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Physiology (medical) ,Medical imaging ,Humans ,Medicine ,030212 general & internal medicine ,Adverse effect ,Lead (electronics) ,Equipment Safety ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Body region ,Radiology ,Artifacts ,Cardiology and Cardiovascular Medicine ,business - Abstract
Magnetic resonance imaging (MRI) at 3.0 T is becoming more common, but there is a lack of sufficient evidence on the safety of a 3.0 T scan in patients with pacemakers. This study aimed to investigate the safety and practical concerns of 3.0 T scans for patients with MR-conditional pacemakers. Twenty consecutive patients were enrolled. A standardized protocol was developed by cardiologists, pacemaker engineers, and radiologists. Pacemaker interrogation was performed immediately before and after the scan. Scan-related adverse events were documented, and imaging quality was graded as level 1 to 4 by radiologists. Twenty-three MRI scans of different body regions (brain = 13, lumbar spine = 4, cervical spine = 2, and heart = 4) were performed, and the average time of a scan was 25 ± 11 min. No significant changes in sensing amplitude (atrial 3.1 ± 1.1 mV vs. 2.9 ± 1.2 mV, P = 0.71; ventricular 9.3 ± 3.5 mV vs. 10.2 ± 3.4 mV, P = 0.46), lead impedances (atrial 647 ± 146 Ω vs. 627 ± 151 Ω, P = 0.7; ventricular: 780 ± 247 Ω vs.711 ± 226 Ω, P = 0.36), or pacing threshold (atrial 0.6 ± 0.2 V/0.4 ms vs. 0.6 ± 0.2 V/0.4 ms, P = 0.71; ventricular 0.7 ± 0.3 V/0.4 ms vs. 0.7 ± 0.2 V/0.4 ms, P = 0.85) were observed pre- and postscan. No adverse events were detected. Image quality review showed grade 1 quality in 16 patients and grade 2 quality in 4 patients with artifacts of pulse generators and leads in cardiac MRI scan and no impact on diagnostic value. Our initial data indicated that 3.0 T scanning might be feasible under a standardized protocol with good diagnostic imaging quality irrespective of body region in patients with MR-conditional pacemakers.
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- 2020
10. Integrin β1D Deficiency–Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
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Jiang Hong, Shihua Zhao, Zhenwei Pan, Duane D. Hall, Long-Sheng Song, Xiuyu Chen, Ling Shi, Minjie Lu, Chen Cui, Chunyan Li, Biyi Chen, Jinhua Huang, and Yihui Wang
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Male ,Integrins ,Heart disease ,030204 cardiovascular system & hematology ,Ventricular tachycardia ,Ryanodine receptor 2 ,Catecholamines ,0302 clinical medicine ,Protein Isoforms ,Medicine ,Phosphorylation ,Extracellular Signal-Regulated MAP Kinases ,Arrhythmogenic Right Ventricular Dysplasia ,Mice, Knockout ,0303 health sciences ,biology ,Integrin beta1 ,Desmosomes ,Middle Aged ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Ion Channel Gating ,medicine.drug ,Adult ,medicine.medical_specialty ,Integrin ,Down-Regulation ,Article ,Right ventricular cardiomyopathy ,03 medical and health sciences ,Physiology (medical) ,Internal medicine ,Animals ,Humans ,Calcium Signaling ,Aged ,030304 developmental biology ,business.industry ,Myocardium ,Ubiquitination ,Ryanodine Receptor Calcium Release Channel ,medicine.disease ,Fibronectins ,Mice, Inbred C57BL ,Disease Models, Animal ,Increased risk ,Desmoplakins ,Proteolysis ,Tachycardia, Ventricular ,biology.protein ,Catecholamine ,business ,Plakophilins - Abstract
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary heart disease characterized by fatty infiltration, life-threatening arrhythmias, and increased risk of sudden cardiac death. The guideline for management of ARVC in patients is to improve quality of life by reducing arrhythmic symptoms and to prevent sudden cardiac death. However, the mechanism underlying ARVC-associated cardiac arrhythmias remains poorly understood. Methods: Using protein mass spectrometry analyses, we identified that integrin β1 is downregulated in ARVC hearts without changes to Ca 2+ -handling proteins. As adult cardiomyocytes express only the β1D isoform, we generated a cardiac specific β1D knockout mouse model and performed functional imaging and biochemical analyses to determine the consequences of integrin β1D loss on function in the heart in vivo and in vitro. Results: Integrin β1D deficiency and RyR2 Ser-2030 hyperphosphorylation were detected by Western blotting in left ventricular tissues from patients with ARVC but not in patients with ischemic or hypertrophic cardiomyopathy. Using lipid bilayer patch clamp single channel recordings, we found that purified integrin β1D protein could stabilize RyR2 function by decreasing RyR2 open probability, mean open time, and increasing mean close time. Also, β1D knockout mice exhibited normal cardiac function and morphology but presented with catecholamine-sensitive polymorphic ventricular tachycardia, consistent with increased RyR2 Ser-2030 phosphorylation and aberrant Ca 2+ handling in β1D knockout cardiomyocytes. Mechanistically, we revealed that loss of DSP (desmoplakin) induces integrin β1D deficiency in ARVC mediated through an ERK1/2 (extracellular signal–regulated kinase 1 and 2)–fibronectin–ubiquitin/lysosome pathway. Conclusions: Our data suggest that integrin β1D deficiency represents a novel mechanism underlying the increased risk of ventricular arrhythmias in patients with ARVC.
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- 2020
11. Correlation of Myocardial Strain and Late Gadolinium Enhancement by Cardiac Magnetic Resonance After a First Anterior ST-Segment Elevation Myocardial Infarction
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Shiqin Yu, Jinying Zhou, Kai Yang, Xiuyu Chen, Yucong Zheng, Kankan Zhao, Jialin Song, Keshan Ji, Peng Zhou, Hongbing Yan, and Shihua Zhao
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medicine.medical_specialty ,left ventricle ,030204 cardiovascular system & hematology ,Cardiovascular Medicine ,Anterior ST segment elevation ,030218 nuclear medicine & medical imaging ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,strain ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Late gadolinium enhancement ,magnetic resonance imaging ,Myocardial infarction ,cardiovascular diseases ,Original Research ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,ST-segment elevation myocardial infarction ,medicine.anatomical_structure ,late gadolinium enhancement ,Ventricle ,RC666-701 ,Cardiology ,Cardiac magnetic resonance ,business ,Cardiology and Cardiovascular Medicine - Abstract
Objectives: To investigate the correlation of cardiac magnetic resonance (CMR) feature-tracking with conventional CMR parameters in patients with a first anterior ST-segment elevation myocardial infarction (STEMI).Methods: This sub-analysis of OCTAMI (Optical Coherence Tomography Examination in Acute Myocardial Infarction) registry included 129 patients who finished a CMR examination 1 month after a first anterior STEMI. Cine images were applied to calculate both global and segmental left ventricular peak strain parameters. The patients were divided into two groups by left ventricular ejection fraction (LVEF) and compared with 42 healthy controls. Segmental late gadolinium enhancement (LGE) was graded according to LGE transmurality as follows: (1) >0 to ≤ 25%; (2) >25 to ≤ 50%; (3) >50 to ≤ 75%; (4) >75%. Left ventricle was divided into infarcted, adjacent, and remote regions to assess regional function.Results: Compared with controls, global radial (28.39 ± 5.08% vs. 38.54 ± 9.27%, p < 0.05), circumferential (−16.91 ± 2.11% vs. −20.77 ± 2.78%, p < 0.05), and longitudinal (−13.06 ± 2.15 vs. −15.52 ± 2.69, p < 0.05) strains were impaired in STEMI patients with normal LVEF (≥55%). Strain parameters were strongly associated with LGE (radial: r = 0.65; circumferential: r = 0.69; longitudinal: r = 0.61; all p < 0.05). A significant and stepwise impairment of global strains was observed in groups divided by LGE tertiles. Furthermore, segmental strain was different in various degrees of LGE transmurality especially for radial and circumferential strain. Strains of adjacent region were better than infarcted region in radial and circumferential directions and worse than remote region in all three directions.Conclusion: Global and regional strain could stratify different extent and transmurality of LGE, respectively. Although without LGE, adjacent region had impaired strains comparing with remote region.
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- 2021
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12. Multicenter Consistency Assessment of Valvular Flow Quantification With Automated Valve Tracking in 4D Flow CMR
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Carmen P.S. Blanken, Marcus Carlsson, Liang Zhong, Amir Ese, Shihua Zhao, Jos J.M. Westenberg, Jun Mei Zhang, Xiuyu Chen, Pim van Ooij, Tilman Emrich, Savine C S Minderhoud, Hildo J. Lamb, Johan Wittgren, Benjamin Fidock, R. Nils Planken, Jelle J. Goeman, Yu Cong Zheng, Alexander Hirsch, Joe F. Juffermans, Anton Kilburg, Johannes Töger, Pankaj Garg, Graduate School, Radiology and Nuclear Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ANS - Brain Imaging, AMS - Amsterdam Movement Sciences, ACS - Heart failure & arrhythmias, Cardiology, and Radiology & Nuclear Medicine
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automated retrospective valve tracking ,Network Functions Virtualization ,Magnetic Resonance Spectroscopy ,Intraclass correlation ,Regurgitation (circulation) ,030204 cardiovascular system & hematology ,Intracardiac injection ,valvular flow assessment regurgitation ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Consistency (statistics) ,Predictive Value of Tests ,3automated retrospective valve tracking ,Healthy volunteers ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,whole heart 4D flow CMR ,Retrospective Studies ,business.industry ,Flow quantification ,cardiovascular system ,Cardiology and Cardiovascular Medicine ,Cardiac magnetic resonance ,Nuclear medicine ,business - Abstract
OBJECTIVES This study determined: 1) the interobserver agreement; 2) valvular flow variation; and 3) which variables independently predicted the variation of valvular flow quantification from 4-dimensional (4D) flow cardiac magnetic resonance (CMR) with automated retrospective valve tracking at multiple sites. BACKGROUND Automated retrospective valve tracking in 4D flow CMR allows consistent assessment of valvular flow through all intracardiac valves. However, due to the variance of CMR scanners and protocols, it remains uncertain if the published consistency holds for other clinical centers. METHODS Seven sites each retrospectively or prospectively selected 20 subjects who underwent whole heart 4D flow CMR (64 patients and 76 healthy volunteers; aged 32 years [range 24 to 48 years], 47% men, from 2014 to 2020), which was acquired with locally used CMR scanners (scanners from 3 vendors; 2 1.5-T and 5 3-T scanners) and protocols. Automated retrospective valve tracking was locally performed at each site to quantify the valvular flow and repeated by 1 central site. Interobserver agreement was evaluated with intraclass correlation coefficients (ICCs). Net forward volume (NFV) consistency among the valves was evaluated by calculating the intervalvular variation. Multiple regression analysis was performed to assess the predicting effect of local CMR scanners and protocols on the intervalvular inconsistency. RESULTS The interobserver analysis demonstrated strong-to-excellent agreement for NFV (ICC: 0.85 to 0.96) and moderate-to-excellent agreement for regurgitation fraction (ICC: 0.53 to 0.97) for all sites and valves. In addition, all observers established a low intervalvular variation (#10.5%) in their analysis. The availability of 2 cine images per valve for valve tracking compared with 1 cine image predicted a decreasing variation in NFV among the 4 valves (beta =-1.3; p = 0.01). CONCLUSIONS Independently of locally used CMR scanners and protocols, valvular flow quantification can be performed consistently with automated retrospective valve tracking in 4D flow CMR. (J Am Coll Cardiol Img 2021;14:1354-66) (c) 2021 by the American College of Cardiology Foundation.
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- 2021
13. Patients who do not fulfill criteria for hypertrophic cardiomyopathy but have unexplained giant T-wave inversion: a cardiovascular magnetic resonance mid-term follow-up study
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Gang Yin, Shihua Zhao, Zhenhui Zhu, Jinghan Huang, Jing Xu, Jian He, Hao Wang, Bingqi Wei, Shuang Li, Baiyan Zhuang, Xiuyu Chen, Minjie Lu, and Bailing Wu
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medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Segmental wall thickness ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,T wave ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,cardiovascular diseases ,CMR ,Angiology ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Research ,Follow-up study ,Healthy subjects ,Hypertrophic cardiomyopathy ,Arrhythmias, Cardiac ,Magnetic resonance imaging ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Giant T-wave inversion ,Mid term follow up ,RC666-701 ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Background Patients who have unexplained giant T-wave inversions but do not meet criteria for hypertrophic cardiomyopathy (HCM) (left ventricular (LV) wall thickness Methods Seventy-one patients with unexplained giant T-wave inversion who did not fulfill HCM criteria were studied. The mean interval time of the follow-up CMR was 24.4 ± 8.3 months. The LV wall thickness was measured in each LV segment according to the American Heart Association 17-segmented model. The apical angle (ApA) was also measured. A receiver operating curve (ROC) was used to identify the predictive values of the CMR variables. Results Of 71 patients, 16 (22.5%) progressed to typical apical HCM, while 55 (77.5%) did not progress to HCM criteria. The mean apical wall thickness was significantly different between the two groups at both baseline and follow-up, with the apical HCM group having greater wall thickness at both time points (all p p Conclusions CMR metrics identify predictors for progression to HCM in patients with unexplained giant T-wave inversion.
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- 2021
14. Left Ventricular Longitudinal Dyssynchrony by CMR Feature Tracking Is Related to Adverse Prognosis in Advanced Arrhythmogenic Cardiomyopathy
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Lu Li, Xiuyu Chen, Yanyan Song, Richard N.W. Hauer, Keshan Ji, Liang Chen, Minjie Lu, and Shihua Zhao
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medicine.medical_specialty ,dyssynchrony ,medicine.medical_treatment ,Cardiomyopathy ,Cardiovascular Medicine ,Internal medicine ,magnetic resonance imaging ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,Circumferential strain ,Risk factor ,feature tracking ,Original Research ,Heart transplantation ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Confounding ,Magnetic resonance imaging ,arrhythmogenic cardiomyopathy ,medicine.disease ,RC666-701 ,Cardiology ,Feature tracking ,prognosis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives: Left ventricular (LV) involvement has been associated with unfavorable prognosis in arrhythmogenic cardiomyopathy (ACM). We aim to evaluate LV mechanics by cardiovascular magnetic resonance-feature tracking (CMR-FT) in ACM patients with right ventricular (RV) dysfunction.Methods: We retrospectively recruited ACM patients diagnosed according to the revised Task Force Criteria (rTFC) from January 2015 to July 2017. All patients underwent CMR examinations and collections of clinical, electrocardiographic data. The strain and dyssynchrony parameters of LV and RV were analyzed. These patients were followed, and primary study outcome was defined as a composite of cardiovascular events (arrhythmic events and heart transplantation), secondary study outcome included arrhythmic events.Results: Eighty-nine ACM patients (40.40 ± 13.98 years, 67.42% male) were included. LV and RV ejection fractions were 49.12 ± 12.02% and 22.28 ± 10.11%, respectively. During a median (IQR) follow-up for 18.20 (11.60-30.04) months, 30 patients experienced cardiovascular events which included 22 patients who experienced arrhythmic events. Patients with cardiovascular events had impaired LV global longitudinal strain (−10.82 ± 2.77 vs. −12.61 ± 3.18%, p = 0.010), impaired LV global circumferential strain (−11.81 ± 2.40 vs. −13.04 ± 2.83%, p = 0.044), and greater LV longitudinal dyssynchrony (LVLD) (80.98 ± 30.98 vs. 64.23 ± 25.51 ms, p = 0.012) than those without. After adjusting for age, sex, and other confounding factors, LVLD ≥89.15 ms was an independent risk factor for cardiovascular events (HR: 4.50, 95% CI: 1.94 to 10.42; p = 0.001) and for arrhythmic events (HR: 4.79, 95% CI: 1.74 to 13.20; p = 0.003).Conclusions: LVLD by CMR-FT was an independent risk factor for cardiovascular and arrhythmic events in ACM patients in advanced stage, which could provide prognostic value for this subtype.
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- 2021
15. Early detection of left atrial dysfunction assessed by CMR feature tracking in hypertensive patients
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Xiuyu Chen, Weipeng Yan, Gang Yin, Minjie Lu, Chen Cui, Huaibin Cheng, Lu Li, and Shihua Zhao
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Adult ,Male ,medicine.medical_specialty ,Left ventricular hypertrophy ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Left atrial ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,cardiovascular diseases ,Retrospective Studies ,Reproducibility ,Ejection fraction ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Ultrasound ,Reproducibility of Results ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Early Diagnosis ,ROC Curve ,030220 oncology & carcinogenesis ,Hypertension ,cardiovascular system ,Cardiology ,Atrial Function, Left ,Female ,Analysis of variance ,Radiology ,business - Abstract
To evaluate whether early left atrial (LA) dysfunction in hypertension (HTN), with or without left ventricular hypertrophy (LVH), can be detected by cardiovascular magnetic resonance feature tracking (CMR-FT). Seventy-three HTN patients and 29 healthy controls were retrospectively recruited. HTN patients were divided into the LVH (n = 29) and non-LVH group (n = 44). LA performance was analysed using CMR-FT in 2- and 4-chamber cine images, including LA reservoir function (total ejection fraction [EF], total strain [es], peak positive strain rate [SRs]), conduit function (passive EF, passive strain [ee], peak early negative strain rate [SRe]) and booster pump function (booster EF, active strain [ea], late peak negative strain rate [SRa]). One-way analysis of variance with post hoc LSD tests, Spearman analysis, receiver operating characteristic curve and intra-class correlation coefficient analysis were applied for statistical analyses. Compared with healthy controls, LA reservoir (LA total EF, es, SRs) and conduit function (LA passive EF, ee, SRe) were significantly impaired in HTN patients with or without LVH, and these parameters significantly correlated with mitral E/A
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- 2019
16. Stereotactic Body Radiation Therapy for the First-Line Comprehensive Treatment of Oligometastatic Nasopharyngeal Carcinoma: A Prospective, Single-Arm, Phase II Trial
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Yuan Qu, J. Xiao, X. Huang, Juxian Wang, R. Wu, Lu Gao, J. Luo, Xiuyu Chen, Jun-Wu Zhang, K. Wang, Quan Liu, J. Yi, and Yueming Zhang
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Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,medicine.medical_treatment ,First line ,Phases of clinical research ,Bone metastasis ,medicine.disease ,Metastasis ,Radiation therapy ,Oncology ,Nasopharyngeal carcinoma ,medicine ,Clinical endpoint ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Adverse effect - Abstract
Purpose/objective(s) The current treatment strategy for patients with metastatic nasopharyngeal carcinoma (NPC) is mainly based on palliative chemotherapy, with low complete remission rate and poor progression-free survival (PFS). Radiation therapy has proven efficacy in the treatment of patients with nonmetastatic NPC, with emerging indication in the setting of limited metastatic disease. We proposed a single-arm phase II study to determine if metastasis-directed SBRT plus systemic treatment could prolong PFS compared with historical findings at first-line therapy for patients with oligometastatic NPC. Materials/methods We enrolled metastatic NPC with 1-5 metastatic lesions, with all metastases amenable to SBRT. Prescribed doses ranged from 25-50 Gy administered in five fractions. All patients received systemic chemotherapy before or after SBRT. The primary endpoint was PFS at 1 year from the start of SBRT treatment. Results Between October 2016 and January 2020, 24 patients with a median age of 48 years (range, 29-65 years) were recruited. A total of 44 sites were treated with 11 of 24 patients receiving SBRT to more than one site. Spinal bone was most often irradiated. By Kaplan-Meier actuarial analysis, 1-year PFS was 62% and overall survival rate 87%. Most patients progressed in new distant sites with only one local SBRT failures out of 44 lesions. Patients with lung metastasis had a lower chance of distant progression than those with bone metastasis or liver metastasis. There were no SBRT relevant grade 3-5 toxicity, and only one patient suffered from grade 2 adverse event. Conclusion Use of metastasis-directed SBRT with systemic chemotherapy for patients with oligometastatic NPC as first-line therapy was well tolerated, and resulted in high PFS, substantially greater than historical values for patients who only received systemic agents.
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- 2021
17. Response-Adapted Strategy Based on Early Response to Radiotherapy Achieves Favorable Survival With Functional Larynx in Resectable, Locally Advanced Hypopharyngeal Cancer: An Analysis of 423 Real-World Cases
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J. Wang, Yueming Zhang, Quan Liu, R. Wu, G. Xu, Lu Gao, X. Luo, Xiuyu Chen, Jun-Wu Zhang, Xiuqing Huang, J. Yi, Yuan Qu, and J. Luo
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Larynx ,Oncology ,Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,medicine.medical_treatment ,Cancer ,Hypopharyngeal cancer ,Subgroup analysis ,medicine.disease ,Primary tumor ,Hypopharyngeal Carcinoma ,Radiation therapy ,Laryngectomy ,medicine.anatomical_structure ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Abstract
Purpose/Objective(s) The survival and larynx preservation were both important in hypopharyngeal cancer. For primary surgery, most patients need total laryngectomy. For primary radical concurrent chemoradiotherapy (CCRT), the non-responders to CCRT had worse outcome compared with surgery. Thus, our cancer center explored a new response-adapted strategy based on early response to radiotherapy. Materials/Methods A total of 423 patients with resectable, III/IVA hypopharyngeal cancer were reviewed between May 2009 and October 2019. There were three main treatment strategies for locally advanced hypopharyngeal carcinoma in our institution, surgery followed by radiotherapy (S+RT group), response-adapted group and radical CCRT/RT (CRT group). The response-adapted strategy was determined by primary tumor regression evaluated at DT 50 Gy, only primary lesions reaching large PR were recommended for radical CCRT, otherwise planned surgery. We defined the survival with functional larynx as total laryngectomy or death from local disease. Results With a medial follow-up of 66.5 months, the 5-year overall survival (OS), locoregional recurrence-free survival (LRRFS), distance metastasis free survival (DMFS) and survival with functional larynx were 49.5%, 45.7%, 47.0% and 52.5% for whole cohort. For different groups, the 5-year OS, LRRFS, DMFS and survival with functional larynx were 54.4%, 52.5%, 52.3% and 47.4% for S+RT group (n = 144); 52.7%, 47.0%, 49.5% and 58.6% for response-adapted group (n = 212); 27.7%, 28.6%, 26.3% and 41.3% for CRT group (n = 67). The response-adapted strategy achieved similar survival and better survival with functional larynx compared with S+RT group, but the baseline between them were unbalanced. We use PSM to balance the two arms, the adjusted 5-year OS, LRRFS and DMFS were 54.8%, 48.7%, 53.5% for response-adapted group vs 52.2% 50.8%, 50.8% for S+RT group, without significant difference. But the adjusted 5-year larynx preservation rate and survival with functional larynx in response-adapted group were 75.1% and 53.8%, better compared with 56.1% and 50.1% in S+RT group (P 0.05) for two groups had no difference. In subgroup analysis, 87.7% (186/212) required total laryngectomy when evaluated before treatment in the response-adapted group, but the 5-year survival with functional larynx were still 57.4%. In multivariable analysis, treatment strategies, ECOG, T and N stage were independently significant for OS, LRRFS, DMFS and survival with functional larynx. Conclusion The response-adapted strategy achieved favorable survival with functional larynx and equally oncologist outcome compared with S+RT strategy. Besides, the response-adapted strategy did not result in additional operative complications and was well tolerated. Therefore, the response-adapted strategy might be an innovative, desirable for locally advanced hypopharyngeal cancer, especially for those with organ preservation intention.
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- 2021
18. Early Left Ventricular Diastolic Dysfunction and Abnormal Left Ventricular-left Atrial Coupling in Asymptomatic Patients With Hypertension: A Cardiovascular Magnetic Resonance Feature Tracking Study
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Shihua Zhao, Lu Li, Xiuyu Chen, Yanyan Song, Minjie Lu, Xiaoning Shao, and Jingliang Cheng
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Diastole ,030204 cardiovascular system & hematology ,Asymptomatic ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Left atrial ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Heart Atria ,Retrospective Studies ,medicine.diagnostic_test ,Atrium (architecture) ,business.industry ,Area under the curve ,Magnetic resonance imaging ,Hypertension ,Cardiology ,Feature tracking ,Left ventricular diastolic dysfunction ,Atrial Function, Left ,medicine.symptom ,business - Abstract
PURPOSE Hypertension (HTN) patients suffer from increased risk of left ventricular (LV) diastolic dysfunction and LV hypertrophy (LVH). Evaluation of early LV diastolic function requires accurate noninvasive diagnostic tools. The aim of this study was to evaluate whether cardiovascular magnetic resonance feature-tracking (CMR-FT) could detect early LV dysfunction and evaluate LV-left atrium (LA) correlation in HTN patients. MATERIALS AND METHODS In all, 89 HTN patients and 38 age-matched and sex-matched controls were retrospectively enrolled and underwent CMR examination. HTN patients were divided into LVH (n=38) and non-LVH (n=51) groups. All LV deformation parameters were analyzed in radial, circumferential, and longitudinal directions, including peak strain, peak systolic strain rate and peak diastolic strain rate (PDSR), LA strain and strain rate (SR), including LA reservoir function (es, SRs), conduit function (ee, SRe), and booster pump function (ea, SRa). RESULTS Compared with controls, the LV PDSR in radial, circumferential, and longitudinal directions and the LA reservoir and conduit function were significantly impaired in HTN patients regardless of LVH (all P
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- 2020
19. Myocardial remodelling after withdrawing therapy for heart failure in patients with recovered dilated cardiomyopathy: insights from TRED-HF
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Zohya Khalique, John Gregson, Xiuyu Chen, Richard E. Jones, Dudley J. Pennell, Vassilios S. Vassiliou, A. John Baksi, John G.F. Cleland, Daniel Hammersley, Upasana Tayal, Martin R. Cowie, Ricardo Wage, Ruth Owen, Brian P Halliday, Sanjay K Prasad, Amrit Lota, British Heart Foundation, and Guys & St Thomas NHS Foundation Trust
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Cardiomyopathy, Dilated ,Global longitudinal strain ,medicine.medical_specialty ,Cardiac & Cardiovascular Systems ,medicine.drug_class ,Dilated cardiomyopathy ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Extracellular fluid ,PROGNOSTIC-SIGNIFICANCE ,medicine ,Clinical endpoint ,Natriuretic peptide ,Humans ,FIBROSIS ,1102 Cardiorespiratory Medicine and Haematology ,Heart Failure ,Ejection fraction ,Science & Technology ,medicine.diagnostic_test ,Ventricular Remodeling ,business.industry ,Magnetic resonance imaging ,Stroke Volume ,medicine.disease ,Confidence interval ,DYSFUNCTION ,PREVALENCE ,DIASTOLIC FUNCTION ,Cardiovascular System & Hematology ,Heart failure ,Cardiology ,Cardiovascular System & Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Life Sciences & Biomedicine ,Extracellular volume - Abstract
Aims: To characterize adverse ventricular remodelling after withdrawing therapy in recovered dilated cardiomyopathy (DCM). Methods and results: TRED-HF was a randomized controlled trial with a follow-on single-arm cross-over phase that examined the safety and feasibility of therapy withdrawal in patients with recovered DCM over 6 months. The primary endpoint was relapse of heart failure defined by (i) a reduction in left ventricular (LV) ejection fraction >10% and to 10% increase in LV end-diastolic volume and to above the normal range, (iii) a twofold rise in N-terminal pro-B-type natriuretic peptide and to >400 ng/L, or (iv) evidence of heart failure. LV mass, LV and right ventricular (RV) global longitudinal strain (GLS) and extracellular volume were measured using cardiovascular magnetic resonance at baseline and follow-up (6 months or relapse) for 48 patients. LV cell and extracellular matrix masses were derived. The effect of withdrawing therapy, stratified by relapse and genotype, was investigated in the randomized and follow-on phases. In the randomized comparison, withdrawing therapy led to an increase in mean LV mass [5.4 g/m 2; 95% confidence interval (CI) 1.3–9.5] and cell mass (4.2 g/m 2; 95% CI 0.5–8.0) and a reduction in LV (3.5; 95% CI 1.6–5.5) and RV (2.4; 95% CI 0.1–4.7) GLS. In a non-randomized comparison of all patients (n = 47) who had therapy withdrawn in either phase, there was an increase in LV mass (6.2 g/m 2; 95% CI 3.6–8.9; P = 0.0001), cell mass (4.0 g/m 2; 95% CI 1.8–6.2; P = 0.0007) and matrix mass (1.7 g/m 2; 95% CI 0.7–2.6; P = 0.001) and a reduction in LV GLS (2.7; 95% CI 1.5–4.0; P = 0.0001). Amongst those who had therapy withdrawn and did not relapse, similar changes were observed (n = 28; LV mass: 5.1 g/m 2, 95% CI 1.5–8.8, P = 0.007; cell mass: 3.7 g/m 2, 95% CI 0.3–7.0, P = 0.03; matrix mass: 1.7 g/m 2, 95% CI 0.4–3.0, P = 0.02; LV GLS: 1.7, 95% CI 0.1–3.2, P = 0.04). Patients with TTN variants (n = 10) who had therapy withdrawn had a greater increase in LV matrix mass (mean effect of TTN: 2.6 g/m 2; 95% CI 0.4–4.8; P = 0.02). Conclusion: In TRED-HF, withdrawing therapy caused rapid remodelling, with early tissue and functional changes, even amongst patients who did not relapse.
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- 2020
20. Deep learning algorithm to improve hypertrophic cardiomyopathy mutation prediction using cardiac cine images
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Shihua Zhao, Minjie Lu, Gang Yin, Xiuyu Chen, Zhenyu Liu, Lei Song, Lu Li, Hongyu Zhou, Kankan Zhao, Jie Tian, and Hairong Zheng
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Adult ,Male ,High variability ,Magnetic Resonance Imaging, Cine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Deep Learning ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Genetic testing ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,Magnetic resonance imaging ,Heart ,General Medicine ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Mutation ,cardiovascular system ,Female ,business ,Algorithm - Abstract
The high variability of hypertrophic cardiomyopathy (HCM) genetic phenotypes has prompted the establishment of risk-stratification systems that predict the risk of a positive genetic mutation based on clinical and echocardiographic profiles. This study aims to improve mutation-risk prediction by extracting cardiovascular magnetic resonance (CMR) morphological features using a deep learning algorithm. We recruited 198 HCM patients (48% men, aged 47 ± 13 years) and divided them into training (147 cases) and test (51 cases) sets based on different genetic testing institutions and CMR scan dates (2012, 2013, respectively). All patients underwent CMR examinations, HCM genetic testing, and an assessment of established genotype scores (Mayo Clinic score I, Mayo Clinic score II, and Toronto score). A deep learning (DL) model was developed to classify the HCM genotypes, based on a nonenhanced four-chamber view of cine images. The areas under the curve (AUCs) for the test set were Mayo Clinic score I (AUC: 0.64, sensitivity: 64.29%, specificity: 47.83%), Mayo Clinic score II (AUC: 0.70, sensitivity: 64.29%, specificity: 65.22%), Toronto score (AUC: 0.74, sensitivity: 75.00%, specificity: 56.52%), and DL model (AUC: 0.80, sensitivity: 85.71%, specificity: 69.57%). The combination of the DL and the Toronto score resulted in a significantly higher predictive performance (AUC = 0.84, sensitivity: 83.33%, specificity: 78.26%), compared with Mayo I (p = 006), Mayo II (p = 022), and Toronto score (p = 0.029). The combination of the DL model, based on nonenhanced cine CMR images and the Toronto score yielded significantly higher diagnostic performance in detecting HCM mutations. • Deep learning method could enable the extraction of image features from cine images. • Deep learning method based on cine images performed better than established scores in identifying HCM patients with positive genotypes. • The combination of the deep learning method based on cine images and the Toronto score could further improve the performance of the identification of HCM patients with positive genotypes.
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- 2020
21. Arrhythmogenic Left Ventricular Cardiomyopathy: A Clinical and CMR Study
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Jinghan Huang, Baiyan Zhuang, Jing Xu, Yang Wang, Shuang Li, Shihua Zhao, Yong Jiang, Gang Yin, Xuejin Duan, Jian He, Guozhong Li, Xiuyu Chen, Xiaohan Fan, Di Zhou, Li Li, and Minjie Lu
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Male ,medicine.medical_specialty ,Heart Ventricles ,Cardiology ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Image Processing, Computer-Assisted ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,lcsh:Science ,Aged ,Observer Variation ,Multidisciplinary ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Arrhythmias, Cardiac ,Magnetic resonance imaging ,Middle Aged ,Right bundle branch block ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Ventricular cardiomyopathy ,Ventricle ,cardiovascular system ,End-diastolic volume ,Female ,lcsh:Q ,Myocardial fibrosis ,Cardiomyopathies ,business ,Rare disease - Abstract
The clinical features, CMR characteristics and outcomes of arrhythmogenic left ventricular cardiomyopathy (ALVC), which is a very rare nonischemic cardiomyopathy, are currently not well studied. The purpose of the study is to investigate the clinical and cardiovascular magnetic resonance (CMR) imaging characteristics of arrhythmogenic left ventricular cardiomyopathy (ALVC). Fifty-three consecutive patients with ALVC were divided into two groups: ALVC patients without right ventricular (RV) involvement (n = 36, group 1) and those with RV involvement (n = 17, group 2). Clinical symptoms, cardiac electrophysiological findings, and CMR parameters (morphology, ventricular function, and myocardial fibrosis and fatty infiltration) were evaluated in both groups. The two groups showed no significant difference in age, gender, or presenting symptoms (P > 0.05). Right bundle branch block ventricular arrhythmia was less common in patients without RV involvement (50.0% vs.64.7%, P = 0.031). There were no significant differences in left ventricular function between the two groups, however right ventricular ejection fraction was significantly lower in group 2 (40.1 ± 4.0% vs. 48.7 ± 3.9%, P
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- 2020
22. LGE-CMR-derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results
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Xiuyu Chen, Mengjie Fang, Shihua Zhao, Sainan Cheng, Chen Cui, Di Dong, Jie Tian, Gang Yin, and Sanjay K Prasad
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Gadolinium DTPA ,Male ,medicine.medical_specialty ,Systole ,Contrast Media ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,Humans ,Medicine ,Late gadolinium enhancement ,Radiology, Nuclear Medicine and imaging ,Univariate analysis ,Ejection fraction ,business.industry ,Hazard ratio ,Event free survival ,Hypertrophic cardiomyopathy ,General Medicine ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Prognosis ,medicine.disease ,Confidence interval ,Cardiology ,Female ,Radiology ,business ,Cardiac magnetic resonance - Abstract
To evaluate the prognostic value of texture features based on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) images in hypertrophic cardiomyopathy (HCM) patients with systolic dysfunction. 67 HCM patients with systolic dysfunction (41 male and 26 female, mean age ± standard deviation, 46.20 years ± 13.38) were enrolled. All patients underwent 1.5 T CMR cine and LGE imaging. Texture features were extracted from LGE images. Cox proportional hazard analysis and Kaplan-Meier analysis were used to determine the association of texture features and traditional parameters with event free survival. Family history (hazard ratio [HR]=2.558, 95 % confidence interval [CI]=1.060–6.180), NYHA III-IV (HR=5.627, CI=1.652–19.173), left ventricular ejection fraction (HR=0.945, CI=0.902–0.991), left ventricular end-diastolic volume index (HR=1.006, CI=1.000–1.012), LGE extent (HR=1.911, CI=1.348–2.709) and three texture parameters [X0_H_skewness (HR=0.783, CI=0.691–0.889), X0_GLCM_cluster_tendency (HR=0.735, CI=0.616–0.877) and X0_GLRLM_energy (HR=1.344, CI=1.173–1.540)] were significantly associated with event free survival in univariate analysis (p
- Published
- 2018
23. Vessel structural stress mediates aortic media degeneration in bicuspid aortopathy: New insights based on patient-specific fluid-structure interaction analysis
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Xu Wang, Shihua Zhao, Yuetang Wang, Shuo Wang, Fei Li, En Qiao, Gang Yin, Zakaria Meddings, Wei Wang, Qi Gao, Xiuyu Chen, Zhongzhao Teng, Cun-Tao Yu, Teng, Zhongzhao [0000-0003-3973-6157], and Apollo - University of Cambridge Repository
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medicine.medical_specialty ,Bicuspid aortic valve ,Heart Valve Diseases ,Biomedical Engineering ,Biophysics ,Degeneration (medical) ,Wall shear stress ,Bicuspid Aortic Valve Disease ,Vessel structural stress ,Internal medicine ,medicine.artery ,Fluid–structure interaction ,Ascending aorta ,medicine ,Shear stress ,Humans ,Orthopedics and Sports Medicine ,Aorta ,biology ,business.industry ,Rehabilitation ,Hemodynamics ,medicine.disease ,Curvatures of the stomach ,Elastin ,Tissue Degeneration ,Aortic Valve ,biology.protein ,Cardiology ,Stress, Mechanical ,business - Abstract
This study aimed to assess the relationship between local mechanical stimuli and regional aortic tissue degeneration using fluid–structure interaction (FSI) analysis in patients with bicuspid aortic valve (BAV) disease. Nine patients underwent ascending aortic replacement were recruited. Tissues were collected to evaluate the pathology features in four regions, greater curvature (GC-region), posterior (P-region), anterior (A-region), and lesser curvature (LC-region). FSI analysis was performed to quantify vessel structural stress (VSS) and flow-induced parameters, including wall shear stress (WSS), oscillatory shear index (OSI), and particle relative residence time (RRT). The correlation between these biomechanical metrics and tissue degeneration was analyzed. Elastin in the medial layer and media thickness were thinnest and the gap between fibers was biggest in the GC-region, followed by the P-region and A-region, while the elastin and media thickness were thickest and the gap smallest in the LC-region. The collagen deposition followed a pattern with the biggest in the GC-region and least in the LC-region. There is a strong negative correlation between mean or peak VSS and elastin thickness in the arterial wall in the GC-region (r = -0.917; p = 0.001 and r = -0.899; p = 0.001), A-region (r = -0.748; p = 0.020 and r = -0.700; p = 0.036) and P-region (r = -0.773; p = 0.014 and r = -0.769; p = 0.015), and between mean VSS and fiber distance in the A-region (r = -0.702, p = 0.035). Moreover, strong negative correlation between mean or peak VSS and media thickness was also observed. No correlation was found between WSS, OSI, and RRT and aortic tissue degeneration in these four regions. These findings indicate that increased VSS correlated with local elastin degradation and aortic media degeneration, implying that it could be a potential biomechanical parameter for a refined risk stratification for patients with BAV.
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- 2021
24. The Optimal Sequence of Intracranial Radiotherapy Compared to Systematic TKI for Brain Metastases in Targeted Treatment Era
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H. Zhang, J. Xiao, K. Wang, Xiuqing Huang, Y.X. Li, J. Yi, N. Bi, Sujuan Wang, Yueming Zhang, Robert Chunhua Zhao, Quan Liu, Xiuyu Chen, S. Yang, and Yanni Ma
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Oncology ,Cancer Research ,medicine.medical_specialty ,Radiation ,Multivariate analysis ,business.industry ,medicine.medical_treatment ,Salvage therapy ,Retrospective cohort study ,Radiation therapy ,Stereotactic radiotherapy ,Internal medicine ,medicine ,Clinical endpoint ,Radiology, Nuclear Medicine and imaging ,Target therapy ,business ,Adverse effect - Abstract
PURPOSE/OBJECTIVE(S) The high intracranial efficacy of target therapy agents challenges the sequence of local radiation therapy (RT) and systematic tyrosine kinase inhibitors (TKI) in brain metastases (BM) patients. Therefore, we conducted a single institutional retrospective cohort study to demonstrate the appropriate treatment strategy of upfront RT or upfront TKI in these patients, including an assessment of its feasibility and toxicity. MATERIALS/METHODS Patients with brain metastases who received hypofractionated stereotactic radiotherapy (HFSRT) with/without whole brain radiotherapy (WBRT) at our institution from October 2010 to October 2020 were included in this study. The primary endpoint was intracranial progression-free survival (IPFS). The secondary endpoints were overall survival (OS), brain metastases specific survival (BMSS) and toxicity. Intracranial progression was estimated using the Fine-Gray competing risks model. Kaplan-Meier analysis and Log-rank tests were used to evaluate and compare OS and BMSS. Multivariate analysis was performed using Cox logistic regression analysis. RESULTS Among 885 patients, 570 patients enrolled in the study. 130 patients received upfront TKI with RT, 193 patients received upfront RT with TKI, and 247 patients received RT alone. The median follow-up time was 56.4 months. Upfront RT group showed lower intracranial progression risk with adjusted SHR 0.51 (95% CI, 0. 40- 0.667) than upfront TKI group (median IPFS, 17.2 months vs. 8.5 months; P
- Published
- 2021
25. Hypopharyngeal Carcinoma With Synchronous and Metachronous Multiple Malignancies: Clinical Characteristics and Prognosis Analysis of 673 Real World Cases
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G. Xu, Yueming Zhang, Lu Gao, Yuan Qu, Xiuqing Huang, J. Wang, J. Yi, Jun-Wu Zhang, X. Luo, K. Wang, J. Luo, R. Wu, and Xiuyu Chen
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Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,Proportional hazards model ,Second primary cancer ,medicine.disease ,Gastroenterology ,Head and neck squamous-cell carcinoma ,Hypopharyngeal Carcinoma ,medicine.anatomical_structure ,Oncology ,Internal medicine ,Medicine ,Radiology, Nuclear Medicine and imaging ,Digestive tract ,In patient ,Esophagus ,business ,Head and neck - Abstract
PURPOSE/OBJECTIVE(S) Hypopharyngeal carcinoma (HPC) is one of the most devastating malignancies among head and neck cancers. Our aim is to analyze the clinical characteristics and prognosis of synchronous and metachronous second primary malignancies (SPMs) in patients with hypopharyngeal carcinoma. MATERIALS/METHODS We retrospectively reviewed 673 patients diagnosed in our institution between May 2009 and October 2019. Endoscopic examination was performed in 97.1% (654/673) of patients before treatment. We defined a synchronous SPM as which developed within 6 months of the index HPC diagnosis, while a metachronous SPM as which developed more than 6 months after initial diagnosis of HPC. The Kaplan-Meier method, propensity score-matched (PSM) and Cox model were used to analyze the data. RESULTS Within the median follow-up of 66.5 months, 71 (10.5%) patients developed gastric/esophageal tumor in situ (Tis) and 143 (21.2%), patients developed SPMs, consisting of 78 with synchronous SPMs and 75 with metachronous SPMs, respectively, with patient overlap. Among the 143 patients, the most common secondary site was esophagus (n = 85), followed by the head and neck squamous cell carcinoma (HNSCC, n = 36), lung (n = 20) and other cancers (n = 19). The 5-year overall survivals (OS) for non-SPMs (n = 459), SPMs (n = 143) and Tis group (n = 71) were 43.8% vs 37.1% vs 42.9%, respectively. Accordingly, the disease-specific survivals (DSS) were 46.3% vs 56.2% vs 47.8%, respectively. We compared synchronous SPMs and no-SPMs groups, the 5-year OS and DSS were 37.1% and 56.2% for synchronous SPMs group (n = 78), compared with 43.8% (P = 0.093) and 46.3% (P = 0.098) for no-SPMs group (n = 459). We use PSM to balance two arms with the ratio of 1:1, resulting in the number of 62 patients in each group. The adjusted 5-year OS and DSS were 23.6% and 32.7% for synchronous SPMs group (n = 62), compared with 49.8% (P < 0.001) and 52.4% (P < 0.001) for no-SPMs group (n = 62). For synchronous and metachronous SPMs, the 5-year OS and DSS were 27.3% and 40.8% for synchronous SPMs group (n = 78) vs 48.8% (P = 0.001) and 70.7% (P = 0.001) for metachronous SPMs group (n = 75). According to the site of the SPMs, the 5-year OS and DSS were 24.5% and 40.4% for esophagus (n = 85), 51.9% and 66.9% for HNSCC (n = 36), 52.0% and 75.1% for lung (n = 20), 60.7% and 83.9% for others (n = 19). The SPMs in esophagus had worse OS than the other three groups (P
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- 2021
26. Early Left Ventricular Involvement Detected by Cardiovascular Magnetic Resonance Feature Tracking in Arrhythmogenic Right Ventricular Cardiomyopathy: The Effects of Left Ventricular Late Gadolinium Enhancement and Right Ventricular Dysfunction
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Tongtong Han, Xiuyu Chen, Huaibin Cheng, Shihua Zhao, Lin Chen, Lu Li, Minjie Lu, Keshan Ji, and Yanyan Song
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Gadolinium DTPA ,Male ,Time Factors ,Ventricular Dysfunction, Right ,Magnetic Resonance Imaging (MRI) ,Contrast Media ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Imaging ,030218 nuclear medicine & medical imaging ,Ventricular Dysfunction, Left ,Basal (phylogenetics) ,0302 clinical medicine ,magnetic resonance imaging ,Prospective Studies ,Original Research ,Ejection fraction ,medicine.diagnostic_test ,ventricle ,Middle Aged ,Prognosis ,Arrhythmogenic right ventricular dysplasia ,medicine.anatomical_structure ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,arrhythmogenic right ventricular dysplasia ,Adult ,medicine.medical_specialty ,Cardiomyopathy ,Magnetic Resonance Imaging, Cine ,Right ventricular cardiomyopathy ,Young Adult ,03 medical and health sciences ,strain ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Late gadolinium enhancement ,cardiovascular diseases ,business.industry ,Reproducibility of Results ,Stroke Volume ,Magnetic resonance imaging ,medicine.disease ,Early Diagnosis ,Ventricle ,Case-Control Studies ,Ventricular Function, Right ,Feature tracking ,business - Abstract
Background Left ventricular ( LV ) involvement is common in arrhythmogenic right ventricular cardiomyopathy ( ARVC ). We aim to evaluate LV involvement in ARVC patients by cardiovascular magnetic resonance feature tracking. Methods and Results Sixty‐eight patients with ARVC and 30 controls were prospectively enrolled. ARVC patients were divided into 2 subgroups: the preserved LV ejection fraction (LVEF) group ( LVEF ≥55%, n=27) and the reduced LVEF group ( LVEF LGE ) and cardiovascular magnetic resonance feature tracking were performed in all subjects. LV global and regional (basal, mid, apical) peak strain ( PS ) in radial, circumferential and longitudinal directions were assessed, respectively. Right ventricular global PS in three directions were also analyzed. Compared with the controls, LV global and regional PS were all significantly impaired in the reduced LVEF group (all P LV global longitudinal PS as well as mid and apical longitudinal PS were impaired in the preserved LVEF group (all P PS ( r =−0.47, −0.47, and −0.49, respectively, all P LVEF group showed significantly higher prevalence of LGE (95.10% versus 63.00%, P =0.002) than the preserved LVEF group. Moreover, LV radial PS was significantly reduced in LV segments with LGE (33.15±20.42%, n=46) than those without LGE (41.25±15.98%, n=386) in the preserved LVEF group ( P =0.016). Conclusions In patients with ARVC , cardiovascular magnetic resonance feature tracking could detect early LV dysfunction, which was associated with LV myocardial LGE and right ventricular dysfunction.
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- 2019
27. The Value of Low-Dose Dynamic Myocardial Perfusion CT for Accurate Evaluation of Microvascular Obstruction in Patients With Acute Myocardial Infarction
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Yining Wang, Xiuyu Chen, Bin Lu, Xu Dai, Jiayin Zhang, Jingwei Pan, and Mengmeng Yu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Perfusion Imaging ,Contrast Media ,Coronary Angiography ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Myocardial perfusion imaging ,0302 clinical medicine ,Internal medicine ,Coronary Circulation ,medicine ,Late gadolinium enhancement ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Prospective Studies ,Aged ,medicine.diagnostic_test ,business.industry ,Microcirculation ,Low dose ,Curve analysis ,General Medicine ,Blood flow ,Middle Aged ,medicine.disease ,Coronary Vessels ,Magnetic Resonance Imaging ,Iopamidol ,030220 oncology & carcinogenesis ,Microvessels ,Cardiology ,ST Elevation Myocardial Infarction ,Female ,business ,Tomography, X-Ray Computed ,human activities ,Perfusion - Abstract
OBJECTIVE. The purpose of this study was to investigate the diagnostic performance of quantitative parameters generated from dynamic myocardial perfusion CT for assessment of acute myocardial infarction (AMI) and microvascular obstruction (MVO) using cardiac MRI as a reference standard. SUBJECTS AND METHODS. Patients who underwent successful reperfusion treatment within 1 week after AMI between January 1, 2018, and May 31, 2018, were prospectively enrolled. All patients were referred for cardiac MRI and dynamic myocardial perfusion CT on the same day. Various quantitative parameters and late iodine enhancement (LIE) were analyzed for the evaluation of AMI and MVO using cardiac MRI findings as a reference standard. RESULTS. Twenty-seven patients with 442 vascular segments were ultimately included in the analysis. The mean radiation doses ± SD for dynamic myocardial perfusion CT and LIE were 3.3 ± 1.1 mSv and 2.0 ± 0.6 mSv, respectively. Myocardial blood flow (MBF) was significantly lower in segments with MVO than in those without MVO and in reference segments (23.08 ± 7.95 mL/min/100 mL vs 44.60 ± 14.97 mL/min/100 mL and 75.07 ± 7.34 mL/min/100 mL; p < 0.001). According to ROC curve analysis, MBF had the largest AUC of all parameters for identifying AMI with and without MVO as determined by late gadolinium enhancement (LGE) (AUC = 0.941 and 0.996; p < 0.001). The diagnostic accuracy of MBF-based assessment for identifying MVO was 99.2%, which outperformed other quantitative parameters and LIE. We found good correlation between the AMI area and MVO area estimated by MBF and LGE (r = 0.95 and 0.99; p < 0.001). CONCLUSION. MBF derived from dynamic myocardial perfusion CT is accurate and outperforms other quantitative parameters and LIE in diagnosis of AMI and MVO. Area of AMI and MVO can also be accurately estimated using MBF.
- Published
- 2019
28. Proposal Of A TNM Staging Classification System For Esthesioneuroblastoma: A More Precise Prediction Of Prognosis
- Author
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G. Xu, X. Huang, R. Wu, Yujing Zhang, Kai Wang, J. Xiao, Shiping Zhang, M. Sun, J. Yi, Xiuyu Chen, Judong Luo, and Yuan Qu
- Subjects
Cancer Research ,medicine.medical_specialty ,Radiation ,Oncology ,Esthesioneuroblastoma ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,medicine.disease ,business ,TNM staging classification - Published
- 2020
29. Adding Induction Chemotherapy to Preoperative Concurrent Chemoradiotherapy Does Not Improve the Treatment Results in Locally Advanced Hypopharyngeal Carcinoma: A Randomized Phase II Trial
- Author
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Xiuqing Huang, G. Xu, Kai Wang, Lu Gao, J. Yi, Judong Luo, Yuan Qu, Yujing Zhang, J. Wang, Qi Liu, R. Wu, Xiuyu Chen, Jun-Wu Zhang, and X. Luo
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,Locally advanced ,Induction chemotherapy ,Treatment results ,Concurrent chemoradiotherapy ,Hypopharyngeal Carcinoma ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2020
30. A Comparative Analysis of Failure Patterns for Different Pathological Types of Primary Sinonasal Malignancies
- Author
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Lu Gao, Qianwen Liu, R. Wu, Z. Wang, Xiuyu Chen, Xiuqing Huang, Yujing Zhang, Jun-Wu Zhang, G. Xu, J. Wang, J. Yi, and Judong Luo
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Radiation ,Primary (chemistry) ,Oncology ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Pathological - Published
- 2020
31. Clinical Outcomes And Patterns Of Treatment Failure In Patients With Esthesioneuroblastomas (ENB)
- Author
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Yujing Zhang, X. Huang, Judong Luo, Yuan Qu, M. Sun, J. Xiao, Kai Wang, G. Xu, J. Yi, Shiping Zhang, R. Wu, and Xiuyu Chen
- Subjects
Cancer Research ,medicine.medical_specialty ,Radiation ,Oncology ,business.industry ,Internal medicine ,Medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,business ,Treatment failure - Published
- 2020
32. Dynamic Tracking of Injected Mesenchymal Stem Cells after Myocardial Infarction in Rats: A Serial 7T MRI Study
- Author
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Chen Cui, Xiuyu Chen, Shihua Zhao, Minjie Lu, Ning Ma, and Gang Yin
- Subjects
0301 basic medicine ,lcsh:Internal medicine ,medicine.medical_specialty ,Pathology ,Article Subject ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Fibrosis ,medicine ,Myocardial infarction ,lcsh:RC31-1245 ,Ventricular remodeling ,Molecular Biology ,medicine.diagnostic_test ,CD68 ,business.industry ,Mesenchymal stem cell ,Magnetic resonance imaging ,Cell Biology ,medicine.disease ,Surgery ,Transplantation ,030104 developmental biology ,business ,Research Article - Abstract
Purpose.To track the fate of micron-sized particles of iron oxide (MPIO) labeled mesenchymal stem cells (MSCs) in vivo in a rat myocardial infarction model using 7T magnetic resonance imaging (MRI) scanner.Materials and Methods.Male MSCs (2 × 106/50 μL) dual-labeled with MPIO and CM-DiI were injected into the infarct periphery 7 days after myocardial infarction (MI). The control group received cell-free media injection. The temporal stem cell location, signal intensity, and cardiac function were dynamically assessed using a 7T MRI at 24 h before transplantation (baseline), 3 days, 2 weeks, and 4 weeks after transplantation, respectively.Results.MR hypointensities caused by MPIOs were observed on T2⁎-weighted images at all time points after MSCs injection. Cine-MRI showed that MSCs moderated progressive left ventricular remodeling. Double staining for iron and CD68 revealed that most of the iron-positive cells were CD68-positive macrophages. Real-time PCR for rat SRY gene showed the number of survival MSCs considerably decreased after transplantation. MSC-treated hearts had significantly increased capillary density in peri-infarct region and lower cardiomyocytes apoptosis and fibrosis formation.Conclusions.Iron particles are not a reliable marker for in vivo tracking the long-term fate of MSCs engraftment. Despite of poor cell retention, MSCs moderate left ventricular remodeling after MI.
- Published
- 2016
33. Effects of Multidisciplinary Team Care Based on 5E's Renal Rehabilitation for Peritoneal Dialysis Patients in Guangxi Zhuang Autonomous Region of China: A Randomized Controlled Trial
- Author
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Gang Meng, Yanlin Huang, Yixin Luo, Xiuyu Chen, and Yongsheng Zhang
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,medicine.medical_treatment ,030232 urology & nephrology ,Peritonitis ,030204 cardiovascular system & hematology ,Multidisciplinary team ,law.invention ,Peritoneal dialysis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Medicine ,Humans ,Aged ,Patient Care Team ,Rehabilitation ,Self-management ,business.industry ,Incidence (epidemiology) ,Incidence ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Treatment Outcome ,Nephrology ,Inclusion and exclusion criteria ,Kidney Failure, Chronic ,Female ,business ,Peritoneal Dialysis - Abstract
Background: The number of patients with peritoneal dialysis (PD) in China has been increasing year after year, but there are still some challenge in the management of PD patients, and the efficient and effective method has yet to be developed. Multidisciplinary team (MDT) is to create a standardized, individualized, and continuous integrated treatment program for the patients, to ensure the best efficacy and improve patient outcomes. 5E’s renal rehabilitation was originally developed by the Life Options Rehabilitation Advisory Council in 1997 to achieve better management of PD patients. However, there is still no relevant study combining these 2 methods and applying to PD patients so far. Methods: A randomized controlled trial was undertaken in the nephrology department of the First Affiliated Hospital of Guangxi Medical University. We recruited 146 patients according to inclusion and exclusion criteria and divided them into study group (n = 73) and control group (n = 73) using SPSS random number. The control group received routine care and follow-up, while the study group received MDT care based on 5E’s renal rehabilitation. The self-management scale for PD patients and the incidence of dialysis-related peritonitis were compared before discharge and 12 months after discharge. Results: T tests showed that there were no significant differences between the 2 groups in the 5 subscales of Self-management Scale for PD patients at the baseline measures (p > 0.05). However, after 12 months of intervention, the study group gained higher scores in the 5 subscales while the control group declined. And the study group improved statistically significant compared with the control group on “Solution bag replacement (t = 3.103, p = 0.002),” “Troubleshooting during operation (t = 3.978, p ≤ 0.001),” “Diet management (t = 3.201, p = 0.002),”and “Emotion management and return to social life (t = 3.552, p = 0.001)” subscales. Moreover, the peritonitis occurrence rate of the study group (1/68.1 patient month) was statistically significantly lower than that of control group (1/29.4 patient month; p = 0.047). Conclusions: MDT care based on 5E’s renal rehabilitation is beneficial for patients undergoing PD and helpful to improve self-management ability and reduce the incidence of peritonitis.
- Published
- 2018
34. P687Arrhythmogenic right ventricular cardiomyopathy patients with desmoglein-2 variants are characterized by recessive inheritance and progressive heart failure
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Q T Hu, Shengshou Hu, Ningning Zhang, L L Gao, Keping Chen, Jiangping Song, Man Rao, Xiuyu Chen, Y H Ni, Youyi Zhang, and Luonan Chen
- Subjects
medicine.medical_specialty ,Recessive inheritance ,business.industry ,Internal medicine ,Heart failure ,medicine ,Cardiology ,Desmoglein-2 ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Right ventricular cardiomyopathy - Published
- 2018
35. Retrospective Electrocardiography-Gated Real-Time Cardiac Cine MRI at 3T: Comparison with Conventional Segmented Cine MRI
- Author
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Gang Yin, Minjie Lu, Yanyan Song, Sanjay K Prasad, Weipeng Yan, Shihua Zhao, Lu Li, Yan Zhang, Sainan Cheng, Chen Cui, and Xiuyu Chen
- Subjects
Adult ,Male ,Image quality ,Heart Ventricles ,Magnetic Resonance Imaging, Cine ,Breath Holding ,Electrocardiography ,Magnetic resonance imaging ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,cardiovascular diseases ,Cardiovascular Imaging ,Retrospective Studies ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Arrhythmias, Cardiac ,Stroke Volume ,Gold standard (test) ,Stroke volume ,Cardiac cine ,Middle Aged ,Cine mri ,cardiovascular system ,Real-time acquisition ,Female ,Original Article ,business ,Nuclear medicine - Abstract
Objective Segmented cardiac cine magnetic resonance imaging (MRI) is the gold standard for cardiac ventricular volumetric assessment. In patients with difficulty in breath-holding or arrhythmia, this technique may generate images with inadequate quality for diagnosis. Real-time cardiac cine MRI has been developed to address this limitation. We aimed to assess the performance of retrospective electrocardiography-gated real-time cine MRI at 3T for left ventricular (LV) volume and mass measurement. Materials and Methods Fifty-one patients were consecutively enrolled. A series of short-axis cine images covering the entire left ventricle using both segmented and real-time balanced steady-state free precession cardiac cine MRI were obtained. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and LV mass were measured. The agreement and correlation of the parameters were assessed. Additionally, image quality was evaluated using European CMR Registry (Euro-CMR) score and structure visibility rating. Results In patients without difficulty in breath-holding or arrhythmia, no significant difference was found in Euro-CMR score between the two techniques (0.3 ± 0.7 vs. 0.3 ± 0.5, p > 0.05). Good agreements and correlations were found between the techniques for measuring EDV, ESV, EF, SV, and LV mass. In patients with difficulty in breath-holding or arrhythmia, segmented cine MRI had a significant higher Euro-CMR score (2.3 ± 1.2 vs. 0.4 ± 0.5, p < 0.001). Conclusion Real-time cine MRI at 3T allowed the assessment of LV volume with high accuracy and showed a significantly better image quality compared to that of segmented cine MRI in patients with difficulty in breath-holding and arrhythmia.
- Published
- 2018
36. The Diagnosis and Comprehensive Treatment of Leptomeningeal Metastasis: A Phase II Trial
- Author
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S. Yang, Y.X. Li, Xiuyu Chen, Yanni Ma, Robert Chunhua Zhao, J. Xiao, N. Bi, Yantao Tian, Qianwen Liu, Yujing Zhang, Yingjie Xu, and H. Zhang
- Subjects
Cancer Research ,medicine.medical_specialty ,Radiation ,Oncology ,business.industry ,Phase (matter) ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Leptomeningeal metastasis - Published
- 2018
37. CMR assessment and clinical outcomes of hypertrophic cardiomyopathy with or without ventricular remodeling in the end-stage phase
- Author
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Shihua Zhao, Sanjay K Prasad, Hideki Ota, Yeon Hyeon Choe, Lu Li, Gang Yin, Sainan Cheng, Chen Cui, Minjie Lu, and Xiuyu Chen
- Subjects
Adult ,Gadolinium DTPA ,Male ,medicine.medical_specialty ,Multivariate analysis ,Heart Ventricles ,Contrast Media ,Magnetic Resonance Imaging, Cine ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Disease-Free Survival ,Ventricular Function, Left ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Edema ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,030212 general & internal medicine ,Stage (cooking) ,Ventricular remodeling ,Cardiac imaging ,Proportional Hazards Models ,Retrospective Studies ,Heart Failure ,Chi-Square Distribution ,Ventricular Remodeling ,business.industry ,Proportional hazards model ,Hypertrophic cardiomyopathy ,Reproducibility of Results ,Atrial fibrillation ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Prognosis ,Multivariate Analysis ,cardiovascular system ,Cardiology ,Disease Progression ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
End-stage phase of hypertrophic cardiomyopathy (ES-HCM) is a recognized part of HCM disease spectrum. Information on cardiac magnetic resonance (CMR) studies for ES-HCM especially for those without ventricular remodeling has been limited. We aimed to evaluate the morpho-functional and tissue features of ES-HCM with or without ventricular remodeling and to explore CMR prognostic value in these patients. We analysed CMR scans of sixty-three ES-HCM patients and divided them into those with ventricular dilatation (D-ES, n = 41) and those with normal ventricular size (N-ES, n = 22). Cox proportional hazards models were used to assess the association between CMR parameters and outcomes. Patients in D-ES showed hypokinetic-dilated HCM phenotype, while patients in N-ES showed hypokinetic-restrictive HCM phenotype. LGE extent was significantly larger in D-ES (34.7% ± 15.4% vs. 22.8% ± 7.7%; P
- Published
- 2017
38. P1604myocardial proteome profiling in patients with arrhythmogenic right ventricular cardiomyopathy compared to those with dilated cardiomyopathy and healthy controls
- Author
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Luonan Chen, Xiuyu Chen, Shengshou Hu, and Jiangping Song
- Subjects
medicine.medical_specialty ,Proteome profiling ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Dilated cardiomyopathy ,In patient ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Right ventricular cardiomyopathy - Published
- 2017
39. Myocardial late gadolinium enhancement: a head-to-head comparison of motion-corrected balanced steady-state free precession with segmented turbo fast low angle shot
- Author
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S. Li, Minjie Lu, X. Yang, Gang Yin, Shihua Zhao, Linlin Dai, Xiuyu Chen, Peter Kellman, Jinghui Li, Andrew E. Arai, H. Fan, Tian Lan, Arlene Sirajuddin, and Yan Zhang
- Subjects
Male ,Heart Diseases ,Head to head ,Image quality ,Gadolinium ,Turbo ,chemistry.chemical_element ,Contrast Media ,030204 cardiovascular system & hematology ,Signal-To-Noise Ratio ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,Breath Holding ,03 medical and health sciences ,0302 clinical medicine ,Nuclear magnetic resonance ,Medicine ,Late gadolinium enhancement ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Steady state free precession ,Heart Failure ,Observer Variation ,medicine.diagnostic_test ,biology ,business.industry ,Myocardium ,Arrhythmias, Cardiac ,General Medicine ,Middle Aged ,biology.organism_classification ,Signal-to-noise ratio (imaging) ,chemistry ,Feasibility Studies ,Female ,business ,Magnetic Resonance Angiography - Abstract
To evaluate the image quality and diagnostic agreement with a head-to-head comparison of late gadolinium enhancement (LGE) images acquired by the motion-corrected (MOCO) balanced steady-state free precession (bSSFP) phase sensitivity inversion recovery (PSIR) and conventional segmented fast low angle shot (FLASH) PSIR methodsIn 59 consecutive patients, signal-to-noise ratios (SNRs), contrast-to-noise ratios (CNRs) of the normal myocardium (NM), LGE, and blood pool (BP) were pair-wise compared between the two different sequences. A further semi-qualitative score system (graded 1 -4) was used to compare the overall image quality (OIQ). The diagnostic agreement of the two techniques were evaluated by both transmural severity and absolutely quantitative size of LGE.The SNRs of the NM, LGE, and BP of MOCO bSSFP were 4.8±3.4, 53.6±35.6 and 43.2±29.3, compared with 3.9±3.6 (p=0.126), 27.7±18.5 (p0.001) and 24.3±13.4 (p0.001) of FLASH LGE, respectively. The CNRs of LGE to NM, LGE to BP, and BP to NM were 48.3±33.1 versus 23.8±16.7 (p0.001), 6.5±21.6 versus 3.8±10.8 (p0.001), and 38.3±27.2 versus 20.3±10.7 (p=0.448), respectively. The OIQ of MOCO bSSFP was higher than that of segmented FLASH (median 4 versus median 3, p0.001). For quantification of LGE size, there is good agreement and high correlation (r=0.992, p0.001) between the two methods.MOCO bSSFP is a feasible, robust sequence for LGE imaging, especially for patients with arrhythmia and those incapable of breath-holding due to severe heart failure.
- Published
- 2017
40. The Patterns of Cervical Lymph Node Metastasis and Risk Factors of Retropharyngeal Lymph Node Metastasis Based on MR Imaging in Different Sites of Hypopharyngeal Carcinoma
- Author
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R. Wu, Xiuyu Chen, Xiuqing Huang, Hao Wang, Lu Gao, J. Yi, Kai Wang, Yujing Zhang, Judong Luo, and Yuan Qu
- Subjects
Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,Lymph node metastasis ,medicine.disease ,Mr imaging ,Metastasis ,Hypopharyngeal Carcinoma ,Retropharyngeal lymph nodes ,Oncology ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Published
- 2019
41. Research on application of artificial intelligence model in automobile machinery control system
- Author
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Xiuyu Chen
- Subjects
Engineering ,business.industry ,Mechanical Engineering ,Stiffness ,Kinematics ,Shock absorber ,Software ,Control system ,Automotive Engineering ,Genetic algorithm ,medicine ,Optimisation algorithm ,Artificial intelligence ,medicine.symptom ,Suspension (vehicle) ,business - Abstract
To improve the kinematics and ride comfort of the vehicle suspension system, this paper combines the ADAMS software with the artificial intelligence optimisation algorithm to simulate and optimise the suspension system of a certain type of off-road vehicle. The front suspension of a 1/2 virtual prototype model is established in ADAMS/view, and the kinematics analysis of the prototype model is made. In order to improve the kinematics characteristics of the front suspension, the genetic algorithm and the immune algorithm are used to optimise the positioning parameters of the front suspension based on the kinematics analysis of the suspension. The dynamic model of the whole vehicle is established in ADAMS/view, and the vehicle ride comfort is simulated and calculated. The spring stiffness and shock absorber damping of the rear suspension are optimised by using the immune algorithm, and the purpose of improving the ride comfort of the vehicle is realised.
- Published
- 2019
42. The Long Term Results of Adding Chemotherapy to Intensity-Modulated Radiation Therapy in the Treatment of Stage II Nasopharyngeal Carcinoma - A Multicenter Phase 2 Study
- Author
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Chong Zhao, J. Yi, Lu Gao, and Xiuyu Chen
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Chemotherapy ,Radiation ,business.industry ,medicine.medical_treatment ,Phases of clinical research ,Long term results ,Intensity-modulated radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Stage II Nasopharyngeal Carcinoma ,medicine ,Radiology, Nuclear Medicine and imaging ,030223 otorhinolaryngology ,business - Published
- 2018
43. A pilot trial of autologous bone marrow mononuclear cell transplantation through grafting artery: A sub-study focused on segmental left ventricular function recovery and scar reduction
- Author
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Minjie Lu, Shengshou Hu, Xiuyu Chen, Liangxin Tian, Sheng Liu, Shihua Zhao, Shi-liang Jiang, Gang Yin, Lei Song, Huaibing Chen, Qiyin Chen, Zuo-Xiang He, and Zhe Zheng
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Magnetic Resonance Imaging, Cine ,Pilot Projects ,Transplantation, Autologous ,Peripheral blood mononuclear cell ,Ventricular Function, Left ,Contractility ,Cicatrix ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Coronary Artery Bypass ,Ventricular remodeling ,Bone Marrow Transplantation ,Ejection fraction ,business.industry ,Stroke Volume ,Stem-cell therapy ,Middle Aged ,medicine.disease ,Coronary Vessels ,Surgery ,Transplantation ,Treatment Outcome ,medicine.anatomical_structure ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Background Our preliminary study suggested that patients with chronic myocardial infarction (MI) and heart failure could potentially benefit from CABG combined with aBM-MNC by improving global left ventricular (LV) function. The purpose of this sub-study was to quantitatively evaluate the effectiveness of aBM-MNC transplantation during CABG in patients with chronic MI by intensively analyzing the global and segmental LV function, the scar, and the relationships between the function recovery and the scar transmural extent. Methods A randomized, double-blinded, placebo-controlled study was performed in 50 patients with chronic MI. The patients were randomly allocated into CABG with stem cell transplantation (group A) and CABG only (group B) groups. CMR assessments of global and segmental left ventricular function and scar tissue were performed before surgery and repeated at 12months after CABG and aBM-MNC transplantation. Results The left ventricular ejection fraction (LVEF) improved by 13.5% and 8.0% in group A and B respectively (P=0.04). Segmental analysis of regional LV function recovery indicated that more improvement in contractility was found in group A within the same degree of the infarct transmurality (P=0.017) and showed a predominant interaction in the most severely affected segments (76–100%, P=0.016). Decrease in infarct size between the two groups did not reach statistical difference (9.4% vs. 6.0%, P=0.100). Conclusions CMR assessments revealed reversed ventricular remodeling and improved systolic function and scar reduction in patients who underwent aBM-MNC transplantation during CABG. And the conjunctional use of CABG and stem cell therapy could improve the left ventricular function in patients with chronic MI.
- Published
- 2013
44. Predictors of Outcome After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy
- Author
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Huaibing Cheng, Jinghan Huang, Yong Jiang, Zuo-Xiang He, Shihua Zhao, Yan Zhang, Gang Yin, Lei Song, Xiuyu Chen, Hui Du, Hao Wang, Zhan Gao, Jian Ling, Minjie Lu, and Jinghui Li
- Subjects
Ablation Techniques ,Adult ,Male ,medicine.medical_specialty ,Alcohol septal ablation ,Time Factors ,medicine.medical_treatment ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,Obstructive cardiomyopathy ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Basal (phylogenetics) ,0302 clinical medicine ,Refractory ,Predictive Value of Tests ,Internal medicine ,Heart Septum ,medicine ,Humans ,Ventricular outflow tract ,Survival rate ,Retrospective Studies ,Observer Variation ,Ethanol ,medicine.diagnostic_test ,business.industry ,Patient Selection ,Reproducibility of Results ,Magnetic resonance imaging ,Recovery of Function ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Ablation ,Echocardiography, Doppler ,Treatment Outcome ,ROC Curve ,Area Under Curve ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background— Alcohol septal ablation (ASA) is used for treatment of medically refractory hypertrophic obstructive cardiomyopathy patients with severe left ventricular outflow tract (LVOT) obstruction. The current recommendations restrict the procedure to adults with favorable anatomy and no other coexisting surgically amenable disease. Some patients remain symptomatic with residual LVOT obstruction, thus better patient selection is required. Methods and Results— One-hundred and two consecutive subjects with hypertrophic obstructive cardiomyopathy who underwent cardiovascular magnetic resonance imaging, transthoracic echocardiography, and ASA were enrolled in this study. Successful ASA was defined as reduction of LVOT gradient ≥50% of baseline by echocardiographic follow-up 6 months post ASA. The relationships between segmental thickness assessed by cardiovascular magnetic resonance imaging and echocardiography and outcomes of ASA were compared between the 2 groups. The survival rate after ablation was 100% at 6-month follow-up. The LVOT gradient decreased ≥50% of baseline in 72% (73/102) patients. There were good correlations between the reduction of postoperative LVOT gradient and the thickness of basal anterior segment ( r =0.371; P r =0.527; P r =0.672; P P Conclusions— Both echocardiography and cardiovascular magnetic resonance imaging can be used effectively as noninvasive tools for patient selection for ASA procedure. A significantly thickened septum among hypertrophic obstructive cardiomyopathy patients may be associated with a poor outcome after ASA.
- Published
- 2016
45. Comparison of cardiovascular magnetic resonance characteristics and clinical consequences in children and adolescents with isolated left ventricular non-compaction with and without late gadolinium enhancement
- Author
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Jing Wang, Xuhua Chen, Wei Xiangli, Shihua Zhao, Jielin Pu, Huaibing Cheng, Cuihong Hou, Jianmin Chu, Sanjay K Prasad, Chen Cui, Lihuan Li, Xiuyu Chen, Gang Yin, Shu Zhang, and Minjie Lu
- Subjects
Gadolinium DTPA ,Male ,Time Factors ,medicine.medical_treatment ,Contrast Media ,Kaplan-Meier Estimate ,Late gadolinium enhancement ,Ventricular Function, Left ,Risk Factors ,Prospective Studies ,Child ,Prospective cohort study ,Children ,Medicine(all) ,Heart transplantation ,Isolated Noncompaction of the Ventricular Myocardium ,Ejection fraction ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Age Factors ,Stroke volume ,Predictive value of tests ,embryonic structures ,Cohort ,Disease Progression ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,China ,medicine.medical_specialty ,Adolescent ,Magnetic Resonance Imaging, Cine ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Angiology ,business.industry ,Research ,Myocardium ,Stroke Volume ,Magnetic resonance imaging ,Myocardial Contraction ,Left ventricular non-compaction ,Heart Transplantation ,Cardiovascular magnetic resonance ,business ,Nuclear medicine - Abstract
Background Although cardiovascular magnetic resonance (CMR) is showing increasingly diagnostic potential in left ventricular non-compaction (LVNC), relatively little research relevant to CMR is conducted in children with LVNC. This study was performed to characterize and compare CMR features and clinical outcomes in children with LVNC with and without late gadolinium enhancement (LGE). Methods A cohort of 40 consecutive children (age, 13.7 ± 3.3 years; 29 boys and 11 girls) with isolated LVNC underwent a baseline CMR scan with subsequent clinical follow-up. Short-axis cine images were used to calculate left ventricular (LV) ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), myocardial mass, ratio of non-compacted-to-compacted myocardial thickness (NC/C ratio), and number of non-compacted segments. The LGE images were analyzed to assess visually presence and patterns of LGE. The primary end point was a composite of cardiac death and heart transplantation. Results The LGE was present in 10 (25 %) children, and 46 (27 %) segments were involved, including 23 non-compacted segments and 23 normal segments. Compared with LGE- cohort, LGE+ cohort had significantly lower LVEF (23.8 ± 10.7 % vs. 42.9 ± 16.7 %, p
- Published
- 2015
46. Magnetic Resonance Imaging with Superparamagnetic Iron Oxide Fails to Track the Long-term Fate of Mesenchymal Stem Cells Transplanted into Heart
- Author
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Xiuyu Chen, Shihua Zhao, Gang Yin, Yue Tang, Minjie Lu, Qiong Liu, Lianfeng Zhang, Hao Zhu, Huaibing Cheng, Xianmin Meng, and Ning Ma
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Myocardial Infarction ,Apoptosis ,Mesenchymal Stem Cell Transplantation ,Ventricular Function, Left ,Article ,chemistry.chemical_compound ,In vivo ,medicine ,Animals ,DAPI ,Magnetite Nanoparticles ,Multidisciplinary ,TUNEL assay ,medicine.diagnostic_test ,business.industry ,CD68 ,Macrophages ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Rats ,Disease Models, Animal ,Microscopy, Fluorescence ,chemistry ,Cell Tracking ,Stem cell ,business - Abstract
MRI for in vivo stem cell tracking remains controversial. Here we tested the hypothesis that MRI can track the long-term fate of the superparamagnetic iron oxide (SPIO) nanoparticles labelled mesenchymal stem cells (MSCs) following intramyocardially injection in AMI rats. MSCs (1 × 106) from male rats doubly labeled with SPIO and DAPI were injected 2 weeks after myocardial infarction. The control group received cell-free media injection. In vivo serial MRI was performed at 24 hours before cell delivery (baseline), 3 days, 1, 2 and 4 weeks after cell delivery, respectively. Serial follow-up MRI demonstrated large persistent intramyocardial signal-voids representing SPIO during the follow-up of 4 weeks and MSCs did not moderate the left ventricular dysfunction. The TUNEL analysis confirmed that MSCs engrafted underwent apoptosis. The histopathological studies revealed that the site of cell injection was infiltrated by inflammatory cells progressively and the iron-positive cells were macrophages identified by CD68 staining, but very few or no DAPI-positive stem cells at 4 weeks after cells transplantation. The presence of engrafted cells was confirmed by real-time PCR, which showed that the amount of Y-chromosome-specific SRY gene was consistent with the results. MRI may not reliably track the long-term fate of SPIO-labeled MSCs engraftment in heart.
- Published
- 2015
47. Effects of Prolonged Radiation Treatment Time on Survival in Nasopharyngeal Carcinoma Treated With Combined IMRT and Chemotherapy
- Author
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J. Wang, Min-Yu Chen, Lin Li, Xiuyu Chen, and Yuan Yuan Chen
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Chemotherapy ,Radiation ,business.industry ,medicine.medical_treatment ,medicine.disease ,Nasopharyngeal carcinoma ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Treatment time ,business - Published
- 2015
48. The relationship between electrocardiographic changes and CMR features in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy
- Author
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Shi-liang Jiang, Wei Xiangli, Shihua Zhao, Tao Zhao, Minjie Lu, Xiuyu Chen, Sanjay K Prasad, and Gang Yin
- Subjects
Adult ,Gadolinium DTPA ,Male ,medicine.medical_specialty ,Adolescent ,Heart Ventricles ,Cardiomyopathy ,Contrast Media ,Magnetic Resonance Imaging, Cine ,Ventricular Septum ,Asymptomatic ,Muscle hypertrophy ,Electrocardiography ,Young Adult ,Internal medicine ,T wave ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Aged ,medicine.diagnostic_test ,business.industry ,Myocardium ,Hypertrophic cardiomyopathy ,Magnetic resonance imaging ,Stroke Volume ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Fibrosis ,Heart Block ,Echocardiography ,cardiovascular system ,Cardiology ,End-diastolic volume ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
To investigate the relationship between electrocardiographic (ECG) abnormalities and left ventricular (LV) segmental hypertrophy and myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy (HCM). 118 asymptomatic or mildly symptomatic patients with HCM were examined with late gadolinium enhancement (LGE) CMR, 12-lead ECG, and echocardiography. The distribution and magnitude of LV segmental hypertrophy and LGE were assessed and analyzed in relation to ECG abnormalities. Abnormal electrocardiograms were found in 113 of 118 (95%) patients. Negative T waves were associated with greater apical septal thickness (P = 0.009) and an increased ratio of LV septum to free wall thickness (P = 0.01). Giant negative T waves (GNT) were found in 19 patients (16%), and were associated with apical HCM (P0.001), greater apical thickness (P = 0.004), and increased ratio of LV apical to basal wall thickness (P0.001). However, no significant association was demonstrated between GNT and apical LGE (P = 0.71). Abnormal Q waves were associated with greater basal anteroseptal thickness (P = 0.001), maximal basal thickness (P = 0.004), and more segments with extensive LGE (75% wall thickness involved) (P = 0.001). LV hypertrophy was related to greater LV mass (P = 0.002) and LV end diastolic volume (P = 0.002). In addition, a modest but significant correlation was observed between maximum LV wall thickness and the Romhilt-Estes score (r = 0.41, P0.001). GNT were associated with apical HCM and an increased ratio of LV apical to basal wall thickness. Abnormal Q waves were related to basal anteroseptal hypertrophy and segmental extensive LGE.
- Published
- 2014
49. T-wave inversions related to left ventricular basal hypertrophy and myocardial fibrosis in non-apical hypertrophic cardiomyopathy: a cardiovascular magnetic resonance imaging study
- Author
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Shi-liang Jiang, Tao Zhao, Shihua Zhao, Sanjay K Prasad, Minjie Lu, Xiuyu Chen, and Gang Yin
- Subjects
Male ,medicine.medical_specialty ,Statistics as Topic ,Magnetic Resonance Imaging, Cine ,Sensitivity and Specificity ,Muscle hypertrophy ,Basal (phylogenetics) ,Electrocardiography ,T wave ,Internal medicine ,Medicine ,Late gadolinium enhancement ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,medicine.diagnostic_test ,business.industry ,Myocardium ,Hypertrophic cardiomyopathy ,Reproducibility of Results ,Magnetic resonance imaging ,Arrhythmias, Cardiac ,General Medicine ,Middle Aged ,medicine.disease ,Fibrosis ,Cardiology ,Myocardial fibrosis ,Female ,Hypertrophy, Left Ventricular ,business - Abstract
Objectives To investigate the relationship between T-wave inversions and left ventricular (LV) segmental hypertrophy and myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) in patients with non-apical hypertrophic cardiomyopathy (HCM). Methods 196 consecutive patients with non-apical HCM underwent late gadolinium enhancement (LGE) CMR and 12-lead electrocardiogram. The distribution and magnitude of LV segmental hypertrophy and LGE were assessed according to the AHA 17-segment model and analyzed in relation to T-wave inversions. Results Of 196 HCM patients, 144 (73%) exhibited T-wave inversions. 144 (73%) patients had evidence of myocardial fibrosis as defined by LGE, and the prevalence of LGE was significantly higher in patients with T-wave inversions compared with those without T-wave inversions (78% vs. 59%, P = 0.008). T-wave inversions were related to basal anterior and basal anteroseptal LGE (20% vs. 10%, P = 0.04 and 68% vs. 46%, P = 0.005, respectively). In addition, T-wave inversions were associated with greater basal anteroseptal and basal inferior wall thickness (19.5 ± 4.7 mm vs. 16.7 ± 4.5 mm, P P = 0.01, respectively). By logistic regression analysis, basal anteroseptal wall thickness and LGE were independent determinants of T-wave inversions ( P = 0.005, P = 0.01, respectively). Conclusions T-wave inversions in HCM are associated with LGE and wall thickness of the left ventricular basal segments. Moreover, basal anteroseptal wall thickness and LGE are independent determinants of T-wave inversions.
- Published
- 2013
50. Three-Dimensional Phase-Sensitive Inversion-Recovery Turbo FLASH Sequence for the Assessment of Left Ventricular Myocardial Scar in Swine
- Author
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Jing An, Ranxu Zhao, Yue Tang, Xiuyu Chen, Shihua Zhao, Tao Zhao, Minjie Lu, Shi-liang Jiang, Gang Yin, and Xiaoning Shao
- Subjects
Multidisciplinary ,Statement (logic) ,Phase sensitive ,business.industry ,Science ,lcsh:R ,Library science ,Correction ,lcsh:Medicine ,Inversion recovery ,Bioinformatics ,Medicine ,lcsh:Q ,business ,lcsh:Science - Abstract
The first and second authors, Xiuyu Chen and Minjie Lu, should be indicated as having contributed equally to the work. In addition multiple funding organizations and grants were incorrectly omitted from the Funding Statement. The Funding Statement should read: "This study was supported in part by the Research Grant of National Natural Science Foundation of China (81000604 and 81370036 ),PUMC Youth Fund and the Fundamental Research Funds for the Central Universities (2009-xhj04# and 3332013105), and Grant for Talent Research Star of Fuwai Hospital (2012‐FWXX01). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."
- Published
- 2013
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