22 results on '"Xiaofeng Qu"'
Search Results
2. Impacts of obesity on global subclinical left cardiac function represented by CMR-derived myocardial strain, TyG index may be a predictor
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Jiajie Mei, Yanhua Li, Jianli Dong, Miaomiao Bai, Yinong Jiang, Xiaofeng Qu, and Lili Yin
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Medicine ,Science - Abstract
Abstract Obesity is a recognized risk factor for heart failure. People with similar weights may have different metabolic health. Notably, insulin resistance is a hallmark of obesity and a feature of heart failure. We aimed to evaluate the effects of obesity and metabolic health status on subclinical left cardiac function. We also investigated whether insulin resistance (TyG index) plays a role in BMI-linked subclinical left cardiac dysfunction. The study involved 403 volunteers. Hierarchical multiple regression models were used to assess associations between obesity, metabolic health, and overall subclinical left cardiac function. Mediating analysis was used to explore the role of the TyG index in the association between BMI and left cardiac function. Finally, ROC analysis was performed to explore the predictive value of the TyG index in subclinical left cardiac dysfunction. The correlation analysis showed that metabolic unhealth increased the risk of subclinical left ventricular (LV) dysfunction; obesity was associated with an increased risk of global left cardiac dysfunction regardless of metabolic health status. The TyG index mediated 25% of the associations between BMI and Left atrial (LA) functional parameters. ROC analysis exhibited that the TyG index can be used as a predictor of LA dysfunction (AUC = 0.63), and the optimal cut-off point for the TyG index is 9.33. Even a “non-obese metabolically unhealthy” is a detrimental state of early LV function; obesity remains a major risk factor for global subclinical left cardiac dysfunction. Using the TyG index could allow early identification of individuals at high risk of subclinical left cardiac dysfunction. Registration number: ChiCTR2200057991; Date of registration: 2022-03-25. URL: http://www.chictr.org.cn/showproj.aspx?proj=162316 .
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- 2023
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3. Machine learning-based CT radiomics model to discriminate the primary and secondary intracranial hemorrhage
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Jianbo Lyu, Zhaohui Xu, HaiYan Sun, Fangbing Zhai, and Xiaofeng Qu
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Medicine ,Science - Abstract
Abstract It is challenging to distinguish between primary and secondary intracranial hemorrhage (ICH) purely by imaging data, and the two forms of ICHs are treated differently. This study aims to evaluate the potential of CT-based machine learning to identify the etiology of ICHs and compare the effectiveness of two regions of interest (ROI) sketching methods. A total of 1702 radiomic features were extracted from the CT brain images of 238 patients with acute ICH. We used the Select K Best method, least absolute shrinkage, and selection operator logistic regression to select the most discriminable features with a support vector machine to build a classifier model. Then, a ten-fold cross-validation strategy was employed to evaluate the performance of the classifier. From all quantitative CT-based imaging features obtained by two sketch methods, eighteen features were selected respectively. The radiomics model outperformed radiologists in distinguishing between primary and secondary ICH in both the volume of interest and the three-layer ROI sketches. As a result, a machine learning-based CT radiomics model can improve the accuracy of identifying primary and secondary ICH. A three-layer ROI sketch can identify primary versus secondary ICH based on the CT radiomics method.
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- 2023
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4. Fast detection of dam zone boundary based on Otsu thresholding optimized by enhanced harris hawks optimization.
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Xiaofeng Qu, Jiajun Wang, Xiaoling Wang, Yike Hu, Tianwen Tan, and Dong Kang
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Medicine ,Science - Abstract
Earth-rock dams are among the most important and expensive infrastructure projects. A key safety issue is dam zone boundary detection to prevent the intrusion of materials from different zones. However, existing detection methods strongly highly depend on human judgement, which is time consuming and labor intensive. To solve this problem, this work proposes a fast boundary detection method based on the Otsu algorithm optimized by enhanced Harris hawks optimization (HHO). Compared with the original Otsu algorithm, the proposed method has a higher computation speed to meet the time requirements of engineering projects. Particle swarm optimization is adopted to enhance the exploration stage of HHO. In addition, a tangent function and chaotic sine map are used to improve the convergence speed and robustness. The application of the proposed method to a real-life project shows that the calculation time can be reduced to 20 s, which is approximately 18.8% of the original calculation time.
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- 2023
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5. Pharmacokinetics of anti-HBV polyoxometalate in rats.
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Juan Wang, Xiaofeng Qu, Yanfei Qi, Jinhua Li, Xiuling Song, Li Li, Dehui Yin, Kun Xu, and Juan Li
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Medicine ,Science - Abstract
Polyoxometalates are non-nucleoside analogs that have been proven to exhibit broad-spectrum antiviral activity. In particular, Cs2K4Na[SiW9Nb3O40].H2O 1 shows low toxicity and high activity against HBV. The preclinical pharmacokinetics of Compound 1 in rats were characterized by establishing and applying inductively coupled plasma-mass spectrometry method to determine the concentration of W in plasma, urine, feces, bile and organ samples. The quantitative ICP-MS method demonstrated good sensitivity and application in the pharmacokinetics study of polyoxometalates. The pharmacokinetic behavior of Compound 1 after intravenous or oral administration fit a two-compartment model. Tmax ranges from 0.1 h to 3 h and the T1/2 of Compound 1 is between 20 h and 30 h. The absolute bioavailability of Compound 1 at 45, 180 and 720 mg/kg groups were 23.68%, 14.67% and 11.93%, respectively. The rates of plasma protein binding of Compound 1 at 9, 18 and 36 mg/ml of Compound 1 are 62.13±9.41%, 71.20±24.98% and 49.00±25.59%, respectively. Compound 1 was widely distributed throughout the body, and high levels of compound 1 were found in the kidney and liver. The level of Compound 1 in excretion was lower: 30% for urine, 0.28% for feces and 0.42% for bile, respectively. For elaborate pharmacokinetic characteristics to be fully understood, the metabolism of Compound 1 needs to be studied further.
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- 2014
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6. Study on the Correlation Between Ischemic Leukoaraiosis and Cerebral Large Artery Stenosis Using the Stages of the Preinfarction Period Based on the Result of Computed Tomography Perfusion
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Caifang Ni, Xiaowen Deng, Taojie Ren, Bo Li, Chunxing Li, Yuan Chen, Shifu Sun, and Xiaofeng Qu
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Male ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Leukoaraiosis ,Large artery ,Arteries ,Constriction, Pathologic ,Middle Aged ,medicine.disease ,Correlation ,Perfusion ,Stenosis ,Internal medicine ,Cohort ,medicine ,Cardiology ,Humans ,Stage (cooking) ,Cerebral perfusion pressure ,business ,Tomography, X-Ray Computed ,Computed tomography angiography ,Aged - Abstract
BACKGROUND AND OBJECTIVE The influence of cerebral large artery stenosis (CLAS) on ischemic leukoaraiosis (LA) remains elusive. Based on the proposed stages of the preinfarction period, this study aimed to adopt the staging system to assess the correlation between ischemic LA and CLAS. MATERIALS AND METHODS Patients with unilateral CLAS ≥50% and without cerebral stroke were screened. The severity and distribution of stenosis were evaluated on computed tomography angiography images. The degree of regional cerebral perfusion was rated according to the stages of preinfarction period: 0=normal, 1=stage Ia, 2=stage Ib, 3=stage IIa, 4=stage IIb. Stage I included stage Ia and stage Ib. Stage II included stage IIa and stage IIb. LA was scored with Fazakas scale on T2-weighted image and/or fluid-attenuated inversion recovery sequences. RESULTS The cohort consisted of 212 patients (mean age, 66.89±11.39 y), including 145 (68.40%) males. CLAS severity and distribution did not differ between patients with and without LA (P>0.05). Normal, stage I, and stage II had significantly different incidences of LA and hemispheric LA scores in the left and right hemispheres (P
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- 2021
7. Carotid Web Misdiagnosis
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Yang Gao, Shifu Sun, Taojie Ren, and Xiaofeng Qu
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Cerebral infarction ,Digital subtraction angiography ,Fibromuscular dysplasia ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Bypass surgery ,030220 oncology & carcinogenesis ,medicine.artery ,Occlusion ,medicine ,Anterior cerebral artery ,Surgery ,Neurology (clinical) ,Radiology ,business ,Stroke ,030217 neurology & neurosurgery ,Computed tomography angiography - Abstract
Background A carotid web (CW), an atypical fibromuscular dysplasia, is rare and may cause ischemic stroke. It is challenging to recognize a CW promptly and treat it accordingly. We report a case of an initially misdiagnosed CW. Case Description A 48-year-old man with recurrent cerebral infarction was transferred to our hospital for bypass surgery. Imaging performed at our facility showed multiple old infarct lesions and cerebral tissue hypoperfusion in the occluded left middle cerebral artery territory. Bypass surgery was performed without perioperative complications. While searching for the cause of his stroke, we found a thin intraluminal filling defect along the posterior wall of the left carotid bulb just beyond the carotid bifurcation on sagittal maximal intensity projection images, axial thin-cut images, and volume rendering images. The defect was diagnosed as a CW. It was also detected on follow-up ultrasonography. Owing to our initial unawareness, we did not photograph the carotid bulb during preoperative digital subtraction angiography and postoperative computed tomography angiography. Although the patient was treated with bypass, the persistence of the factors underlying the CW may induce further thrombosis and subsequent occlusion of his ipsilateral anterior cerebral artery. Conclusions Clinicians should be aware of CW as a potential cause of ischemic stroke. Head and neck computed tomography angiography is a reliable imaging method to detect CWs.
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- 2020
8. An automatic personalized internal fixation plate modeling framework for minimally invasive long bone fracture surgery based on pre-registration with maximum common subgraph strategy
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Wen Qi, Xiaofeng Qu, Wenpeng Liu, Yang Yiqian, Bin Liu, Mingzhe Wang, Xiaohui Zhang, and Song Zhang
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Surface (mathematics) ,0209 industrial biotechnology ,medicine.medical_specialty ,Computer science ,medicine.medical_treatment ,Base (geometry) ,Iterative closest point ,020207 software engineering ,02 engineering and technology ,Computer Graphics and Computer-Aided Design ,Industrial and Manufacturing Engineering ,Computer Science Applications ,Surgery ,Visualization ,020901 industrial engineering & automation ,Minimum bounding box ,Principal component analysis ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Fracture (geology) ,Internal fixation - Abstract
In this paper, a visualization and modeling method for the internal fixation plate in personalized and minimally invasive long bone fracture surgery is presented. This framework mainly includes six sub-steps: firstly, the Principal Component Analysis (PCA) method is used to extract the 3D axis of the broken bone; secondly, the Gauss mapping method is utilized to segment the end surfaces of the broken bone; thirdly, the maximum common subgraph strategy is utilized to complete the end surface matching; fourthly, the OBB (Oriented Bounding Box) method is utilized to accomplish the pre-registration of the fracture surface; fifthly, the ICP (Iterative Closest Point) algorithm is utilized to achieve the fracture surface models’ accurate alignment; lastly, the personalized bent internal fixation plate model can be reconstructed based on anchor points. Via this method, doctors can obtain the accurate and personalized internal fixation plate model that has the best matching geometric form to the patient’s broken bones. This method can provide a well technique base and computational solution for the minimally invasive long bone fracture surgery.
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- 2019
9. Asymmetric pathological pachymeningeal enhancement: A new imaging feature for cerebral venous thrombosis
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Ying Liu, Qingwen Sun, Qi Yang, Zhaoyang Fan, Debiao Li, Xiaofeng Qu, and Ce Zhang
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Adult ,Male ,medicine.medical_specialty ,Clinical onset ,03 medical and health sciences ,Sinus Thrombosis, Intracranial ,0302 clinical medicine ,Meninges ,medicine ,Humans ,Thrombus ,Pathological ,Retrospective Studies ,Imaging Feature ,Venous Thrombosis ,medicine.diagnostic_test ,business.industry ,Angiography, Digital Subtraction ,Magnetic resonance imaging ,Retrospective cohort study ,General Medicine ,Phlebography ,Middle Aged ,medicine.disease ,Cerebral Veins ,Magnetic Resonance Imaging ,Venous thrombosis ,Early Diagnosis ,030220 oncology & carcinogenesis ,Case-Control Studies ,Surgery ,Female ,Neurology (clinical) ,Intracranial Atherosclerosis ,Radiology ,Dura Mater ,Intracranial Thrombosis ,business ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
Purpose Cerebral venous thrombosis (CVT) has various clinical presentations and has a median onset delay of 7 days. So it is important to find more identifiable early imaging manifestations for CVT. Method This was a retrospective study. Patients with CVT (CVT group, n = 26) diagnosed by conventional imaging techniques (magnetic resonance imaging and/or digital subtraction angiogram) and patients with symptomatic intracranial atherosclerosis (control group, n = 30) were included. Magnetic resonance black-blood thrombus imaging (MRBTI) technique had been performed in both groups. The CVT group was divided into 3 groups based on the duration of clinical onset: ≤7 days (group 1), between 7 and 30 days (group 2), and >30 days (group 3). Pathological pachymeningeal enhancement and its characteristics were analyzed between the CVT group and the control group. Results Pathological pachymeningeal enhancement was found in 14 CVT patients (54 %) and none in control group (P value = 0.000). The bilateral pathological pachymeningeal enhancement was involved in 10 CVT patients, 6 patients were asymmetric, and 4 patients had ipsilateral enhancement. Asymmetric pathological pachymeningeal enhancement was 71 % and predominantly located on the thrombosed sinus side. Strong enhancement was found in the venous sinus wall beside the thrombus. Pathological pachymeningeal enhancement percentages of three subgroups were 75 % in group 1, 55 % in group 2, and 29 % in group 3 and had no statistical differences (p value = 0.198). Conclusions Current findings suggest asymmetrical pathological pachymeningeal enhancement was associated was CVT and may be a new imaging feature for CVT.
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- 2020
10. Layer-by-layer assembly of polyoxometalate-pyrene-decorated fluorescent microspheres for the suspension immunoassay of Listeria monocytogenes
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Dehui Yin, Kun Xu, Li Li, Gang Yan, Li Juan, Wen Ju, Yangguang Li, Xiuling Song, Wang Juan, and Xiaofeng Qu
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Detection limit ,Materials science ,Chromatography ,medicine.diagnostic_test ,Biomedical Engineering ,Analytical chemistry ,02 engineering and technology ,General Chemistry ,General Medicine ,Conjugated system ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Photobleaching ,Fluorescence ,0104 chemical sciences ,Matrix (chemical analysis) ,chemistry.chemical_compound ,chemistry ,Immunoassay ,medicine ,Pyrene ,General Materials Science ,0210 nano-technology ,Luminescence - Abstract
A fluorescence microsphere suspension array technique has been developed as a promising tool for the molecular detection of Listeria monocytogene (LM), which is a dangerous food borne pathogen that can cause severe food intoxication in both humans and animals. In such a technique, fluorescent microspheres as the key matrix for detection are often decorated with neutral organic dyes, which usually suffer from instability, easy photobleaching and loss from the matrix. Herein, we design and synthesize a new organic–inorganic hybrid POM–pyrene compound [N(C4H9)4]2[V6O13{(OCH2)3CNH–CH2–C16H9}2] (1), which is employed as a negatively-charged fluorescent material to prepare a new class of fluorescent microspheres by a layer-by-layer electrostatic self-assembly method. As a result, such POM–pyrene-decorated fluorescent microspheres possess obvious luminescence properties, superior photo-stability and long-term stability. Therefore, the POM–pyrene-decorated fluorescent microspheres are conjugated by monoclonal anti-LM antibodies, and introduced into the fluorescence microsphere-based suspension immunoassay system for the detection of LM in food, which exhibits a high sensitivity. The lowest limit of detection (LOD) of LM in artificially contaminated meat is down to 6 CFU g−1 without cross-reactivity with other pathogens. Furthermore, the suspension immunoassay based on PS@POM–pyrene microspheres shows excellent specificity to LM, good repeatability and high efficiency in contrast to the conventional culture-based method.
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- 2020
11. Augmented reality surgical navigation with accurate CBCT-patient registration for dental implant placement
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Longfei Ma, Guochen Ning, Xiaofeng Qu, Hongen Liao, Weipeng Jiang, Boyu Zhang, and Xinran Zhang
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Cone beam computed tomography ,medicine.medical_treatment ,0206 medical engineering ,Biomedical Engineering ,Mandible ,02 engineering and technology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,medicine ,Humans ,Dental implant ,Dental Implants ,Orthodontics ,business.industry ,Human physiology ,Cone-Beam Computed Tomography ,Patient registration ,020601 biomedical engineering ,Computer Science Applications ,Surgery, Computer-Assisted ,3d image ,Calibration ,Augmented reality ,Implant ,business - Abstract
It is challenging to achieve high implant accuracy in dental implant placement, because high risk tissues need to be avoided. In this study, we present an augmented reality (AR) surgical navigation with an accurate cone beam computed tomography (CBCT)-patient registration method to provide clinically desired dental implant accuracy. A registration device is used for registration between preoperative data and patient outside the patient's mouth. After registration, the registration device is worn on the patient's teeth for tracking the patient. Naked-eye 3D images of the planning path and the mandibular nerve are superimposed onto the patient in situ to form an AR scene. Simultaneously, a 3D image of the drill is overlaid accurately on the real one to guide the implant procedure. Finally, implant accuracy is evaluated postoperatively. A model experiment was performed by an experienced dentist. Totally, ten parallel pins were inserted into five 3D-printed mandible models guided by our AR navigation method and through the dentist's experience, respectively. AR-guided dental implant placement showed better results than the dentist's experience (mean target error = 1.25 mm vs. 1.63 mm; mean angle error = 4.03° vs. 6.10°). Experimental results indicate that the proposed method is expected to be applied in the clinic. Graphical abstract ᅟ.
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- 2018
12. Development of a low-cost paper-based ELISA method for rapid Escherichia coli O157:H7 detection
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Kaiyue Fu, Xiuling Song, Kun Xu, Hao Bao, Dandan Song, Juan Li, Xiaofeng Qu, Xiangjun Meng, Li Li, Zhuping Zhang, Juan Wang, Chao Zhao, Bo Pang, and Yushen Liu
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Paper ,Detection limit ,Chromatography ,Chemistry ,010401 analytical chemistry ,Biophysics ,Enzyme-Linked Immunosorbent Assay ,Pathogenic bacteria ,02 engineering and technology ,Cell Biology ,Paper based ,Escherichia coli O157 ,021001 nanoscience & nanotechnology ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,medicine ,Lower cost ,Elisa method ,0210 nano-technology ,Molecular Biology ,Escherichia coli - Abstract
Escherichia coli O157: H7 (E. coli O157: H7) has become one of the most dangerous foodborne pathogenic bacteria around the world. Currently, because of the tedious, high-cost and stringent laboratory conditions required, the conventional E. coli O157: H7 detection methods, such as culture-based methods and polymerase chain reaction (PCR), have much limitation. Thus, we developed a novel paper-based enzyme-linked immunosorbent assay (p-ELISA) with shorter operation duration, lower cost, relatively higher sensitivity and wider application. This method required less than 3 h and 5 μL of sample to complete the detection. The limit of detection (LOD) for E. coli O157: H7 reached 1 × 104 CFU/mL with high specificity. To be more suitable for on-site testing, the readout could be rapidly obtained without any expensive instruments. In this study, we chose E. coli O157:H7 as the representative, and our method could provide a platform for determination of other pathogenic bacteria.
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- 2018
13. Recanalization of symptomatic chronic internal carotid artery occlusions by hybrid treatment
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Jianjie Rong, Bo Li, Bingxin Jiang, Yizhi Liu, Xiaofeng Qu, and Weijian Fan
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Adult ,Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,medicine.medical_treatment ,Carotid endarterectomy ,Revascularization ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,medicine ,Humans ,Carotid Stenosis ,Stroke ,Aged ,Retrospective Studies ,Endarterectomy, Carotid ,business.industry ,Endovascular Procedures ,Montreal Cognitive Assessment ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,Reperfusion ,Female ,Stents ,Neurology (clinical) ,Internal carotid artery ,business ,030217 neurology & neurosurgery ,Postoperative Hypertension - Abstract
To evaluate the efficacy and safety of hybrid revascularization by carotid endarterectomy and endovascular intervention in the treatment of chronic internal carotid artery occlusion (ICAO).We performed a retrospective analysis of patients who received hybrid treatment for symptomatic chronic ICAO between December 2016 and December 2018. Fifty-six patients with long-segment ICAO were enrolled and divided into the short duration (1-3 months) and long ICAO duration (3 months) groups, and their clinical and angiographic data were analyzed.The mean duration was 106.8 ± 36.1 days from the date of ICAO diagnosis to revascularization. Totally, 10 patients (17.8%, n = 56) in the short duration group while no patients in the long duration group failed recanalization (n = 7). Perioperative complications included intraoperative thromboembolism in 1 (1.8%) patient and subarachnoid hemorrhage in 2 (3.6%) patients. Early phase postoperative hypertension was noted in 11 (19.6%) patients and cervical hemorrhage in 1 (1.8%) patient. No severe neurological deficits occurred. Overall, the 6-month modified Rankin score, Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in patients with successful recanalization significantly improved versus the baseline (P 0.05). After successful recanalization, the long duration group demonstrated more stents for revascularization compared with the short duration group (P 0.05). Five (10.8%) patients had recurrent transient ischemic attack, and 1 (2.2%) patient developed stroke in the successful revascularization group during 6 months of follow-up. ICA restenosis occurred in 5 (8.9%) patients and re-occlusion was noted in 1 (1.8%) patient.Hybrid operation may be feasible and effective for patients with symptomatic chronic complete ICAO according to our limited data. The original occlusion site from the carotid bifurcation and the duration of ICAO should be considered as independent indicators for successful recanalization as well as perioperative outcomes.
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- 2021
14. Evaluation of the 3D Augmented Reality-Guided Intraoperative Positioning of Dental Implants in Edentulous Mandibular Models
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Longfei Ma, Yingwei Fan, Hongen Liao, Xiaofeng Qu, Boyu Zhang, Xinran Zhang, and Weipeng Jiang
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Computer science ,medicine.medical_treatment ,Point cloud ,Overlay ,Mandible ,Stereotaxic Techniques ,03 medical and health sciences ,User-Computer Interface ,0302 clinical medicine ,Imaging, Three-Dimensional ,medicine ,Humans ,Maxillary central incisor ,Computer vision ,030212 general & internal medicine ,Dental implant ,Dental Implants ,business.industry ,Phantoms, Imaging ,030206 dentistry ,General Medicine ,Surgery, Computer-Assisted ,Virtual image ,Printing, Three-Dimensional ,Augmented reality ,Artificial intelligence ,Implant ,Tomography ,Oral Surgery ,Mouth, Edentulous ,business ,Tomography, X-Ray Computed - Abstract
PURPOSE This research aimed to propose a three-dimensional (3D) augmented reality navigation method with point cloud-based image-patient registration that could merge virtual images in the real environment for dental implants using a 3D image overlay and to evaluate its feasibility. MATERIALS AND METHODS A total of 12 rapid prototyping mandibular models were fabricated using a 3D printing method and were divided into two groups: 3D augmented reality-guided group and traditional two-dimensional (2D) image-guided group. A point cloud-based preoperative image-to-patient registration method was introduced to replace the traditional point-to-point registration. After the registration, dental implant surgery was performed in the two model groups using an augmented reality-guided navigation method and a traditional two-dimensional image-guided navigation method. The planned and actual postoperative implant positions were compared for measuring positional implantation errors. The surgery time was also recorded and compared between the two groups. RESULTS In the model experiment, the root-mean-square deviation of registration was 0.54 mm, and the implant surgery results showed < 1.5-mm mean linear deviation and < 5.5-degree angular deviation. The augmented reality-guided implantation showed smaller horizontal, vertical, and angular errors in the apical areas of the central incisor and the canine region. The surgery time using the augmented reality-guided navigation method was significantly shorter than that using the two-dimensional (2D) image-guided navigation method (P < .05). Moreover, the volunteer experiment demonstrated that the preoperative 3D models in situ accurately overlaid onto the surgical site. CONCLUSION The proposed point cloud-based registration method can achieve excellent registration accuracy. Dental implant placement guided by the proposed 3D augmented reality navigation method showed better accuracy and applicability, as well as higher efficiency, than the traditional 2D image navigation method.
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- 2018
15. Early Detection and Quantification of Cerebral Venous Thrombosis by Magnetic Resonance Black-Blood Thrombus Imaging
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Xiaoming Bi, Xiaofeng Qu, Qi Yang, Christopher Nguyen, Yibin Xie, Kuncheng Li, Xiangying Du, Debiao Li, Jiangang Duan, Zhaoyang Fan, and Xunming Ji
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Signal-To-Noise Ratio ,Sensitivity and Specificity ,Article ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,Cohort Studies ,Sinus Thrombosis, Intracranial ,Young Adult ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,medicine ,Medical imaging ,Humans ,Prospective Studies ,Thrombus ,Child ,Prospective cohort study ,Aged ,Aged, 80 and over ,Venous Thrombosis ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Cerebral Angiography ,Venous thrombosis ,Early Diagnosis ,Intracranial Thrombosis ,Case-Control Studies ,Child, Preschool ,Female ,Neurology (clinical) ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Magnetic Resonance Angiography ,030217 neurology & neurosurgery ,Cerebral angiography - Abstract
Background and Purpose— Early diagnosis of cerebral venous thrombosis (CVT) is currently a major clinical challenge. We proposed a novel magnetic resonance black-blood thrombus imaging technique (MRBTI) for detection and quantification of CVT. Methods— MRBTI was performed on 23 patients with proven CVT and 24 patients with negative CVT confirmed by conventional imaging techniques. Patients were divided into 2 groups based on the duration of clinical onset: ≤7 days (group 1) and between 7 and 30 days (group 2). Signal/noise ratio was calculated for the detected thrombus, and contrast/noise ratio was measured between thrombus and lumen and also between thrombus and brain tissue. The feasibility of using MRBTI for thrombus volume measurement was explored, and total thrombus volume was calculated for each patient. Results— In 23 patients with proven CVT, MRBTI correctly identified 113 of 116 segments with a sensitivity of 97.4%. Thrombus signal/noise ratio was 153±57 and 261±95 for group 1 (n=10) and group 2 (n=13), respectively ( P P Conclusions— The current findings support that with effectively suppressed blood signal, MRBTI allows selective visualization of thrombus as opposed to indirect detection of venous flow perturbation and can be used as a promising first-line diagnostic imaging tool.
- Published
- 2016
16. Development of atherosclerotic-moyamoya syndrome with genetic variant of RNF213 p.R4810K and p.T1727M: A case report
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Xueying Wu, Yongzhong Lin, Zhaoyang Fan, Lele Zhong, Jingdan Cheng, Xiaofeng Qu, and Ying Liu
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medicine.medical_specialty ,Exacerbation ,media_common.quotation_subject ,Ubiquitin-Protein Ligases ,Magnetic resonance angiography ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal medicine ,medicine ,Anterior cerebral artery ,Humans ,Genetic Predisposition to Disease ,030212 general & internal medicine ,media_common ,Adenosine Triphosphatases ,Daughter ,Adult female ,medicine.diagnostic_test ,business.industry ,Haplotype ,Genetic variants ,General Medicine ,Middle Aged ,medicine.disease ,Stenosis ,Cerebrovascular Disorders ,Mutation ,Cardiology ,Surgery ,Female ,Neurology (clinical) ,Moyamoya Disease ,business ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
Objective We report a rare case of atherosclerotic-moyamoya syndrome (A-MMS) in an adult female with genetic variant of both ring finger 213 (RNF213) p.R4810K and p.T1727M. Case report A 46-year-old previously healthy, right-handed woman displayed transient slurred speech, which started to worsen four years ago. Initial magnetic resonance angiography (MRA) revealed stenosis in left middle cerebral artery (MCA), bilateral anterior cerebral artery (ACA), and left posterior cerebral artery (PCA). The patient subsequently underwent catheter angiography, which confirmed the formation of moyamoya vessels, with Suzuki's angiographic staging of grade-3 on the left side. Although the patient had been on both anti-platelet and statin therapy at the time, a follow-up examination showed further exacerbation of left MCA stenosis, along with enhanced moyamoya vessel formation. On black-blood imaging using DANTE-SPACE, there were eccentric, evolving lesions in the left MCA. We next screened for potential genetic variants, using genomic DNA samples isolated from both the patient and her immediate family members. The results showed that the patient, along with her mother, sister, and brother, possessed the heterozygous variant of the RNF213 gene, including c.14429G > A (p.R4810K) and c.5180C > T (p.T1727M). The patient's daughter did not have the variant. Conclusion Collectively, we present a unique case of A-MMS with genetic variant of RNF213 p.R4810K and p.T1727M, manifesting as progression. Based on the family tree, these two mutations are on the same RNF213 haplotype. Whether atherosclerosis is the cause of A-MMS or it further exacerbates the injury of MMD to the A-MMS patients with RNF213 gene variant is a question to be investigated.
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- 2017
17. Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats
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Juan Wang, Wei Nie, Fenglan Niu, Hao Bao, Jinhua Li, Chao Zhao, Xiuling Song, Juan Li, Xiaofeng Qu, Kun Xu, and Li Li
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Male ,Salmonella typhimurium ,Acute oral toxicity ,Administration, Oral ,02 engineering and technology ,Pharmacology ,Kidney ,010402 general chemistry ,medicine.disease_cause ,Antiviral Agents ,01 natural sciences ,lcsh:RA1190-1270 ,In vivo ,Oral administration ,Toxicity Tests, Acute ,medicine ,Animals ,Subchronic oral toxicity ,Pharmacology (medical) ,Prospective Studies ,Rats, Wistar ,lcsh:Toxicology. Poisons ,Mice, Inbred ICR ,Polyoxometalate ,Micronucleus Tests ,business.industry ,lcsh:RM1-950 ,Toxicity Tests, Subchronic ,Tungsten Compounds ,021001 nanoscience & nanotechnology ,Acute toxicity ,Rats ,0104 chemical sciences ,Bioavailability ,lcsh:Therapeutics. Pharmacology ,medicine.anatomical_structure ,Liver ,Toxicity ,Micronucleus test ,Female ,Genotoxicity ,0210 nano-technology ,business ,Mutagens ,Research Article - Abstract
Background Cs2K4Na [SiW9Nb3O40] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications. Methods The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests. Results The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo. Conclusions The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks. Electronic supplementary material The online version of this article (doi:10.1186/s40360-017-0133-x) contains supplementary material, which is available to authorized users.
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- 2017
18. Effect of phosphodiesterase type 5 inhibitors on prostate cancer risk and biochemical recurrence after prostate cancer treatment: A systematic review and meta-analysis
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Qingqing Qian, Ju Xia, Yang Wang, Yang Hong, Xiaofeng Qu, Yougen Wu, and Yuting Gu
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Male ,Oncology ,Biochemical recurrence ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Endocrinology ,Erectile Dysfunction ,Risk Factors ,Internal medicine ,medicine ,Humans ,Prostatectomy ,030219 obstetrics & reproductive medicine ,business.industry ,Prostatic Neoplasms ,General Medicine ,Odds ratio ,Phosphodiesterase 5 Inhibitors ,Prostate-Specific Antigen ,medicine.disease ,Radiation therapy ,Erectile dysfunction ,Relative risk ,Meta-analysis ,Neoplasm Recurrence, Local ,business - Abstract
Recent studies have examined the impact of phosphodiesterase type 5 inhibitors (PDE5-Is) use on the risk of prostate cancer, and biochemical recurrence (BCR) in prostate cancer patients, but the results were inconsistent. A meta-analysis was conducted to assess the associations with all published studies. Databases (PubMed, Web of Science and MEDLINE) were retrieved to identify relevant studies which explored the impact of PDE5-Is use on the risk of prostate cancer, and BCR in prostate cancer patients. The summary results along with 95% confidence intervals (CIs) were calculated. Nine articles were eligible for the inclusion criteria. The pooled analysis showed that PDE5-Is use was not related to the increased risk of prostate cancer (odds ratio (OR), 0.71; 95% CI, 0.40-1.29). Moreover, PDE5-Is use was not linked to BCR risk in prostate cancer patients with erectile dysfunction (ED) following radical prostatectomy or radiation therapy (relative risk (RR), 1.09; 95% CI, 0.89-1.34). The heterogeneity test suggested moderate heterogeneity across studies. PDE5-Is use does not influence the risk of prostate cancer, and BCR in prostate cancer patients. More well-designed studies are warranted to confirm the findings of our analyses.
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- 2018
19. A novel multi-epitope recombined protein for diagnosis of human brucellosis
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Jinhua Liu, Wen Ju, Juan Wang, Xiangjun Meng, Dehui Yin, Han Li, Dandan Song, Yushen Liu, Kun Xu, Juan Li, Xiaofeng Qu, Rizeng Meng, Weiyi Song, Hongqian Cao, Li Li, and Xiuling Song
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0301 basic medicine ,medicine.medical_specialty ,Recombinant protein ,030106 microbiology ,Blotting, Western ,Immunoblotting ,Enzyme-Linked Immunosorbent Assay ,Brucella ,Sensitivity and Specificity ,Epitope ,Brucellosis ,Serology ,law.invention ,03 medical and health sciences ,Epitopes ,Medical microbiology ,Antigen ,law ,Diagnosis ,medicine ,Humans ,Antigens, Bacterial ,biology ,business.industry ,medicine.disease ,biology.organism_classification ,Recombinant Proteins ,030104 developmental biology ,Infectious Diseases ,Parasitology ,ROC Curve ,Immunology ,Recombinant DNA ,business ,Research Article - Abstract
Background In epidemic regions of the world, brucellosis is a reemerging zoonosis with minimal mortality but is a serious public hygiene problem. Currently, there are various methods for brucellosis diagnosis, however few of them are available to be used to diagnose, especially for serious cross-reaction with other bacteria. Method To overcome this disadvantage, we explored a novel multi-epitope recombinant protein as human brucellosis diagnostic antigen. We established an indirect enzyme-linked immunosorbent assay (ELISA) based on this recombinant protein. 248 sera obtained from three different groups including patients with brucellosis (146 samples), non-brucellosis patients (82 samples), and healthy individuals (20 samples) were tested by indirect ELISA. To evaluate the assay, a receiver-operating characteristic (ROC) analysis and immunoblotting were carried out using these characterized serum samples. Results For this test, the area under the ROC curve was 0.9409 (95 % confidence interval, 0.9108 to 0.9709), and a sensitivity of 88.89 % and a specificity of 85.54 % was given with a cutoff value of 0.3865 from this ROC analysis. The Western blot results indicate that it is feasible to differentiate human brucellosis and non-brucellosis with the newly established method based on this recombinant protein. Conclusion Our results obtained high diagnostic accuracy of the ELISA assay which encourage the use of this novel recombinant protein as diagnostic antigen to implement serological diagnosis of brucellosis. Electronic supplementary material The online version of this article (doi:10.1186/s12879-016-1552-9) contains supplementary material, which is available to authorized users.
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- 2015
20. Pharmacokinetics of Anti-HBV Polyoxometalate in Rats
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Xiuling Song, Dehui Yin, Jinhua Li, Li Li, Juan Wang, Juan Li, Xiaofeng Qu, Yanfei Qi, and Kun Xu
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Male ,Drug Research and Development ,Metabolic Clearance Rate ,Immunology ,lcsh:Medicine ,Urine ,Pharmacology ,Antiviral Agents ,General Biochemistry, Genetics and Molecular Biology ,Excretion ,Antiviral Therapy ,Pharmacokinetics ,Oral administration ,Medicine and Health Sciences ,medicine ,Animals ,Tissue Distribution ,Rats, Wistar ,lcsh:Science ,Feces ,Kidney ,Multidisciplinary ,Chemistry ,lcsh:R ,Biology and Life Sciences ,Metabolism ,General Medicine ,Tungsten Compounds ,Vaccination and Immunization ,Blood proteins ,Rats ,medicine.anatomical_structure ,lcsh:Q ,General Agricultural and Biological Sciences ,Research Article - Abstract
Polyoxometalates are non-nucleoside analogs that have been proven to exhibit broad-spectrum antiviral activity. In particular, Cs2K4Na[SiW9Nb3O40].H2O 1 shows low toxicity and high activity against HBV. The preclinical pharmacokinetics of Compound 1 in rats were characterized by establishing and applying inductively coupled plasma-mass spectrometry method to determine the concentration of W in plasma, urine, feces, bile and organ samples. The quantitative ICP-MS method demonstrated good sensitivity and application in the pharmacokinetics study of polyoxometalates. The pharmacokinetic behavior of Compound 1 after intravenous or oral administration fit a two-compartment model. Tmax ranges from 0.1 h to 3 h and the T1/2 of Compound 1 is between 20 h and 30 h. The absolute bioavailability of Compound 1 at 45, 180 and 720 mg/kg groups were 23.68%, 14.67% and 11.93%, respectively. The rates of plasma protein binding of Compound 1 at 9, 18 and 36 mg/ml of Compound 1 are 62.13±9.41%, 71.20±24.98% and 49.00±25.59%, respectively. Compound 1 was widely distributed throughout the body, and high levels of compound 1 were found in the kidney and liver. The level of Compound 1 in excretion was lower: 30% for urine, 0.28% for feces and 0.42% for bile, respectively. For elaborate pharmacokinetic characteristics to be fully understood, the metabolism of Compound 1 needs to be studied further.
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- 2014
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21. Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats
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Dongchun Zheng, Liting Zhou, Xin Chen, Jian Huang, Te Liu, Na Li, Xiaofeng Qu, Guangyan Yu, Jian Zhu, Shuyue Wang, Lin Ye, and Kun Guo
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endocrine system ,medicine.medical_specialty ,Hypothalamo-Hypophyseal System ,Ovary ,Biology ,Female reproductive system ,Toxicology ,Gonadotropin-Releasing Hormone ,chemistry.chemical_compound ,Plasticizers ,Internal medicine ,Diethylhexyl Phthalate ,medicine ,Animals ,Reproductive system ,Rats, Wistar ,Gonadal Steroid Hormones ,GNRHR ,Body Weight ,Uterus ,Phthalate ,Rats ,medicine.anatomical_structure ,Endocrinology ,Endocrine disruptor ,chemistry ,Gene Expression Regulation ,Hypothalamus ,Female ,Reproductive toxicity - Abstract
Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on hypothalamus-pituitary-ovarian axis in adult female rats. Compared with control rats, the DEHP-treated rats showed: (1) lower body weight; (2) lower organ coefficient of ovary; (3) higher GnRH level in the hypothalamus; (4) higher mRNA and protein levels of GnRHR in the pituitary; and (5) lower serum sex hormone levels. Our data reveal that DEHP exposure may lead to the disruption of estrogen biosynthesis pathways in female rats and imbalance of hypothalamus-pituitary-ovarian axis. DEHP may impose negative influence on the development and function of the reproductive system in female rats.
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- 2013
22. Cerebral venous thrombosis: direct thrombus imaging with sub-millimeter isotropic resolution dark-blood CMR
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Yutaka Natsuaki, Qi Yang, Xiaoming Bi, Xiaofeng Qu, Yibin Xie, Guoxi Xie, Debiao Li, and Zhaoyang Fan
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Medicine(all) ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Flow pattern ,Bioinformatics ,medicine.disease ,Image contrast ,Venous thrombosis ,Poster Presentation ,Dark blood ,Medicine ,Radiology, Nuclear Medicine and imaging ,Mr venography ,Radiology ,Thrombus ,Cardiology and Cardiovascular Medicine ,business ,Isotropic resolution ,Angiology - Abstract
Background Cerebral venous thrombosis (CVT) is a disorder potentially leading to devastating disability and even death if not timely diagnosed and treated. While TOF MR venography is most commonly used for diagnosis, the accuracy can be compromised by the flow voids caused by a slow or complex flow pattern and in-plane flow saturation. Several other MR techniques, relying on characteristic image contrast of CVT, may also underor over-estimate the thrombus due to the signals from venous flow and other structures. High-spatial resolution dark-blood CMR could address the above issues, but, to our knowledge, has not been attempted. In this work, a fast dark-blood CMR technique was developed and validated in CVT patients.
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