49 results on '"Woo Sub Shim"'
Search Results
2. A Case With Herpes Zoster Ophthalmicus Mimicking Delayed Complication of Rhinoplasty
- Author
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Il Gu Jung, Hahn Jin Jung, and Woo Sub Shim
- Subjects
herpes zoster ophthalmicus ,hutchinson’s sign ,rhinoplasty ,alloplastic material ,complication ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Herpes zoster ophthalmicus (HZO) occurs due to reactivation of dormant varicella zoster virus infection in the ophthalmic division of the trigeminal nerve. Hutchinson’s sign, a herpetic skin lesion in the nasal tip, is a predictor of ocular complications, as the nasal tip area and ocular structure are innervated by the same nasociliary nerve. Patients who present with Hutchinson’s sign should be referred to an ophthalmologist due to possibility of ocular complications. Here, we present a case of a 44-year-old man with HZO that was confused with delayed rhinoplasty complication. The patient presented with nasal tip skin lesions 17 years after undergoing augmentation rhinoplasty. A graft-related infection was suspected due to operation history and skin lesions. However, surgical exploration disclosed no infection or inflammation, and serological tests revealed positive varicella zoster virus immunoglobulin M, and immunoglobulin G, antibodies. Based on these findings, the patient was diagnosed with HZO. Further, the patient received antiviral treatment with famciclovir. The lesions gradually improved with conservative treatment and became almost unrecognizable. Therefore, HZO should be considered when there is an unexplained skin lesion at the nasal tip in patients with history of rhinoplasty.
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- 2022
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3. Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
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Hahn Jin Jung, Young-Kyung Ko, Woo Sub Shim, Hyun Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Moo Kyun Park, and Doo Hee Han
- Subjects
Medicine ,Science - Abstract
Abstract Diesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear. Therefore, this study aimed to investigate the effect of DEP exposure on AR using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP. Allergic symptom scores, serum total and HDM-specific immunoglobulins (Igs), eosinophil infiltration in the nasal mucosa, cytological profiles in bronchoalveolar lavage fluid (BALF), and cytokine levels in the nasal mucosa and spleen cell culture were analyzed. Mice co-exposed to HDM and DEP showed increased allergic symptom scores compared with mice exposed to HDM alone. Reduced total IgE and HDM-specific IgE and IgG1 levels, decreased eosinophil infiltration in the nasal mucosa, and increased proportion of neutrophils in BALF were found in mice co-exposed to HDM and DEP. Interleukin (IL)-17A level was found to be increased in the nasal mucosa of the co-exposure group compared with that in the HDM-exposed group. The levels of IL-4, IL-13, interferon-γ, IL-25, IL-33, and TSLP expression showed no difference between the groups with and without DEP treatment. Increased expression of IL-17A in the nasal mucosa may contribute to DEP-mediated exacerbation of AR in HDM-sensitized murine AR model.
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- 2021
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4. Evaluation of the Esthetic and Functional Outcomes of Extracorporeal Septoplasty for Rhinoplasty in Asian Patients
- Author
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Sue Jean Mun, Young-Seok Choi, Ji Hwan Kim, Woo Sub Shim, and Hahn Jin Jung
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extracorporeal septoplasty ,rhinoplasty ,asian ,septal extension graft ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Objectives In extracorporeal septoplasty (ECS), the entire septal cartilage is harvested, and a neo-L strut is built extracorporeally. Thus, ECS can simultaneously achieve septum straightening and tip projection. This study evaluated the functional and esthetic outcomes of the ECS technique for rhinoplasty in Asian patients. Methods We conducted a retrospective review of 64 patients who underwent rhinoplasty using ECS between January 2016 and March 2018. Subjective patient satisfaction was assessed and objective surgical outcomes were evaluated. Improvement in nasal obstruction was rated using a visual analog scale (VAS). Anthropometric changes were compared between preoperative and postoperative facial photographs. Complications and revisions were also analyzed. Results The participants comprised 64 patients (48 males and 16 females, with a mean age of 29.3 years). The mean operative time was 89.3 minutes. In total, 61 patients were satisfied with the esthetic outcome, and the overall objective rhinoplasty outcome score was 3.45. Preoperative nasal obstruction symptoms (7.9±1.2 on VAS) improved postoperatively (3.1±1.3, P
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- 2021
- Full Text
- View/download PDF
5. Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study)
- Author
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Doo Hee Han, Jae-Min Shin, Seokyung An, Jong Seung Kim, Dong-Young Kim, Sungji Moon, Jung-Soo Kim, Joong Saeng Cho, Si Whan Kim, Young Hyo Kim, Hwan-Jung Roh, Woo Sub Shim, Ki-Sang Rha, Sang-Wook Kim, Seung-Sin Lee, Dae Woo Kim, Kyu-Sup Cho, Hyo Jin Yim, Sue K. Park, and Chae-Seo Rhee
- Subjects
Rhinitis, Allergic ,Breast Feeding ,Environment ,Delivery, Obstetric ,Cesarean Section ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Objectives There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children. Methods Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. All subjects were divided into AR or non-allergic rhinitis (NAR) groups. Data on environmental factors, mode of delivery and duration of breastfeeding were collected using a questionnaire. Results Compared with short-term breastfeeding (
- Published
- 2019
- Full Text
- View/download PDF
6. A Systematic Review of Benefit of Silicone Intubation in Endoscopic Dacryocystorhinostomy
- Author
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Min Gyu Kang, Woo Sub Shim, Dong Keun Shin, Joo Yeon Kim, Ji-Eun Lee, and Hahn Jin Jung
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Meta-Analysis ,Dacryocystorhinostomy ,Endoscopy ,Silicones ,Failure ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Objectives Insertion of a silicone stent during endoscopic dacryocystorhinostomy (DCR) is the most common procedure to prevent rhinostomy closure. It has been claimed that silicone intubation improves the surgical outcomes of endoscopic DCR. However, many reports have documented an equally high success rate for surgery without silicone intubation. Accordingly, we conducted a systematic review and meta-analysis to clarify the outcomes of endoscopic DCR with and without silicone intubation and determine whether silicone intubation is actually beneficial for patients. Methods PubMed, Embase, and Cochrane Library databases were searched to identify relevant controlled trials evaluating endoscopic DCR with and without silicone intubation. The search was restricted to English articles published between January 2007 and December 2016. Relevant articles were reviewed to obtain information pertaining to interventions and outcomes. We also performed a meta-analysis of the relevant literature. Results In total, 1,216 patients included in 12 randomized controlled trials were pooled. A total of 1,239 endoscopic DCR procedures were performed, and silicone stents were used in 533 procedures. The overall success rate for endoscopic DCR was 91.9% (1,139/1,239), while the success rates with and without silicone intubation were 92.9% (495/533) and 91.2% (644/706), respectively. There was no statistically significant heterogeneity among the included studies. A meta-analysis using a fixed-effects models showed no significant difference in the success rate between endoscopic DCR with silicone intubation and that without silicone intubation (OR, 1.38; 95% CI, 0.89 to 2.12; P=0.148; z=1.45). Furthermore, there were no significant differences with regard to surgical complications such as synechia, granulation, and postoperative bleeding. Conclusion The findings of our meta-analysis suggest that the success rate and postoperative complication rate for endoscopic DCR is not influenced by the use of silicone intubation during the procedure.
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- 2018
- Full Text
- View/download PDF
7. Corrective Septorhinoplasty in Acute Nasal Bone Fractures
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Jisung Kim, Hahn Jin Jung, and Woo Sub Shim
- Subjects
Nasal Bone ,Bone Fractures ,Rhinoplasty ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Objectives Closed reduction is generally recommended for acute nasal bone fractures, and rhinoplasty is considered in cases with an unsatisfactory outcome. However, concomitant rhinoplasty with fracture reduction might achieve better surgical outcomes. This study investigated the surgical techniques and outcomes in patients who underwent rhinoplasty and fracture reduction concomitantly, during the acute stage of nasal bone fracture. Methods Forty-five patients who underwent concomitant rhinoplasty and fracture reduction were enrolled. Nasal bone fractures were classified into three major types (type I, simple fracture; type II, fracture line that mimics nasal osteotomy; and type III, comminuted fracture) based on computed tomography images and preoperative facial images. Two independent otolaryngology-head and neck surgeons evaluated the surgical outcomes and telephone based survey were made to evaluate patients satisfaction. Results Among 45 patients, there were 39 males and 6 females. Type I was the commonest type of fracture with 18 patients (40%), while the most frequently used surgical technique for corrective surgery was dorsal augmentation with 44 patients (97.8%). The mean visual analogue scale satisfaction score of the surgeons and patients were 7.62 and 8, respectively, with no significant differences between fracture types. Conclusion Concomitant rhinoplasty with fracture reduction can be performed for acute nasal bone fracture patients, and it might lead to better aesthetic outcomes.
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- 2018
- Full Text
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8. Effect of a Chitosan Gel on Hemostasis and Prevention of Adhesion After Endoscopic Sinus Surgery
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Young-Jun Chung, Se-Young An, Je-Yeob Yeon, Woo Sub Shim, and Ji-Hun Mo
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Chitosan ,Endoscopy ,Wound Healing ,Hemostasis ,Adverse Effects ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Objectives Postoperative bleeding and adhesion formation are the two most common complications after endoscopic sinus surgery (ESS). The former sometimes can be life threatening and the latter is the most common reason requiring revision surgery. This study was designed to evaluate the effect of newly developed chitosan gel (8% carboxymethyl chitosan, Surgi shield) on hemostasis and wound healing after ESS. Methods A prospective, randomized, double-blind controlled trial was conducted in 33 patients undergoing symmetric ESS. At the conclusion of the operation, Surgi shield was randomly applied on one side of the nasal cavity, with the opposite side acting as control and the bleeding quantity of the surgical field was evaluated every 2 minutes. And then, Merocel was placed in the ethmoidectomized areas of the both sides. Five milliliters of Surgi shield was applied to the Merocel of intervention side and saline was applied to the other side. Merocel in both nasal cavities was removed and 5 mL of Surgi shield was applied again to the intervention side on the second day after surgery. The nasal cavity was examined using a nasal endoscope and the degree of adhesion, crusting, mucosal edema, infection, and granulations were graded at 1, 2, and 4 weeks after surgery. Results Complete hemostasis was rapidly achieved in the Surgi shield applied side compared with the control side at 2, 4, 6, 8, and 10 minutes after application of Surgi shield (P#x0003d;0.007, P#x0003d;0.004, P0.05). No adverse effects were noted in the patient series. Conclusion Surgi shield containing chitosan can be used safely to achieve rapid hemostasis immediately after ESS and to prevent adhesion formation.
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- 2016
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9. The Surgical Outcome of Endoscopic Dacryocystorhinostomy According to the Obstruction Levels of Lacrimal Drainage System
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Ji Chul Choi, Hong-Ryul Jin, Young Eun Moon, Min-Sang Kim, Jae Kwang Oh, Hyun Ah Kim, Mi-Young Choi, and Woo Sub Shim
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Lacrimal sac ,Lacrimal duct obstruction ,Epiphora ,Dacryocystorhinostomy ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
ObjectivesMany factors influence the outcome of endoscopic dacryocystorhinostomy (DCR). One of the most important prognostic factors is the level of obstruction in the lacrimal drainage system. The main objective of this report is to evaluate both the frequency of obstruction by anatomical region of the lacrimal drainage system on dacryocystography (DCG) and the surgical outcome of endoscopic DCR according to the obstruction level.MethodsA retrospective series of 48 patients (60 eyes) who had undergone endoscopic DCR from January 2005 to November 2007 were enrolled. Preoperative evaluation consisted of a standard examination which included lacrimal irrigation, probing, DCG and osteomeatal unit (OMU) computed tomography. Patients were classified into four groups according to the obstruction level on DCG. Surgical outcome was evaluated postoperatively by subjective improvement of epiphora and patent rhinostomy opening on nasal endoscopic exam.ResultsOf 60 eyes, the levels of obstruction were the common canaliculus in 14 eyes (23.3%), the lacrimal sac in 13 eyes (21.7%), the duct-sac junction in 13 eyes (21.7%) and the nasolacrimal duct (NLD) in 20 eyes (33.3%). The ductsac junction obstruction was treated most successfully (100%), followed by NLD obstruction (90%), common canaliculus obstruction (78.6%) and saccal obstruction (69.2%).ConclusionIn patients with lacrimal drainage system obstruction, preoperative evaluation of obstruction level using DCG may be helpful for predicting the surgical outcome of endoscopic DCR. The saccal obstruction may have a worse prognosis than the other obstruction levels.
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- 2009
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10. Non-Functional Parathyroid Adenoma Presenting as a Massive Cervical Hematoma: A Case Report
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Woo Sub Shim, In Kyeong Kim, Seung Du Yoo, and Dong Hwal Kim
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Neck ,Hematoma ,Parathyroid neoplasm ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Parathyroid adenoma usually manifests with symptoms related to hypercalcemia, such as urinary stone and bone fracture. It may also present with asymptomatic hypercalcemia. However, spontaneous cervical hematoma may occur very rarely as a result of extracapsular hemorrhage of a cervical parathyroid adenoma causing acute painful cervical swelling, bruising, dyspnea, hoarseness and dysphagia. We report a 44-year-old woman who manifested as a spontaneous cervical hematoma without any clinical evidence of hyperparathyroidism.
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- 2008
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11. A case of otitis media with effusion due to leiomyoma of the Eustachian tube
- Author
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Hahn Jin Jung, Young Su Kim, Woo Sub Shim, and Dong Keun Shin
- Subjects
medicine.medical_specialty ,Eustachian tube ,business.industry ,medicine.disease ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Otitis ,Leiomyoma ,Otorhinolaryngology ,Effusion ,medicine ,Radiology ,medicine.symptom ,030223 otorhinolaryngology ,business ,030217 neurology & neurosurgery - Published
- 2020
12. Evaluation of the Esthetic and Functional Outcomes of Extracorporeal Septoplasty for Rhinoplasty in Asian Patients
- Author
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Sue Jean Mun, Woo Sub Shim, Young-Seok Choi, Hahn Jin Jung, and Ji Hwan Kim
- Subjects
medicine.medical_specialty ,Visual analogue scale ,medicine.medical_treatment ,Economic shortage ,Extracorporeal ,Rhinoplasty ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Nasal septum ,Medicine ,Extracorporeal Septoplasty ,030223 otorhinolaryngology ,Asian ,business.industry ,Septal Extension Graft ,Surgery ,Septoplasty ,medicine.anatomical_structure ,RF1-547 ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Operative time ,Original Article ,business - Abstract
Objectives. In extracorporeal septoplasty (ECS), the entire septal cartilage is harvested, and a neo-L strut is built extracorporeally. Thus, ECS can simultaneously achieve septum straightening and tip projection. This study evaluated the functional and esthetic outcomes of the ECS technique for rhinoplasty in Asian patients.Methods. We conducted a retrospective review of 64 patients who underwent rhinoplasty using ECS between January 2016 and March 2018. Subjective patient satisfaction was assessed and objective surgical outcomes were evaluated. Improvement in nasal obstruction was rated using a visual analog scale (VAS). Anthropometric changes were compared between preoperative and postoperative facial photographs. Complications and revisions were also analyzed.Results. The participants comprised 64 patients (48 males and 16 females, with a mean age of 29.3 years). The mean operative time was 89.3 minutes. In total, 61 patients were satisfied with the esthetic outcome, and the overall objective rhinoplasty outcome score was 3.45. Preoperative nasal obstruction symptoms (7.9±1.2 on VAS) improved postoperatively (3.1±1.3, PPPP
- Published
- 2020
13. Nasal packing with Merocel in a glove finger after endoscopic endonasal reduction of medial blowout fracture
- Author
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Ji Hwan Kim, Jee Hye Wee, Hahn Jin Jung, Jooyeon Lee, Woo Sub Shim, and Jun Yong Lee
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Adult ,Male ,Natural Orifice Endoscopic Surgery ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Observational Study ,Hemostatics ,Fractures, Bone ,Young Adult ,Formaldehyde ,endoscopic endonasal reduction ,medicine ,Outpatient clinic ,Humans ,Sinusitis ,Reduction (orthopedic surgery) ,Aged ,Retrospective Studies ,Diplopia ,Aged, 80 and over ,Frontal sinus ,Enophthalmos ,business.industry ,Merocel ,General Medicine ,Middle Aged ,medicine.disease ,Symptomatic relief ,Nasal packing ,Surgery ,blowout fracture ,Merocel in a glove finger ,medicine.anatomical_structure ,Polyvinyl Alcohol ,Female ,medicine.symptom ,business ,Orbit ,Research Article ,nasal packing - Abstract
After endoscopic endonasal reduction (EER) for medial blowout fracture (BOF), nasal packing may be necessary for sustaining the reduced orbital contents. This study aimed to introduce a new packing technique using Merocel in a glove finger. We retrospectively reviewed 131 patients with a mean age of 42.2 years (range, 13–80 years), who underwent EER for medial BOF, followed by a postoperative nasal packing of Merocel in a glove finger, between March 2016 and December 2019. Sex, age, side and cause of trauma, pre-operative diplopia and enophthalmos, duration from the occurrence of trauma to surgery, postoperative diplopia, enophthalmos, complications like sinusitis, and revision surgery were evaluated. The most common cause of injury was physical assault in 47 cases and a fall or slip event in 34. Pre-operatively 22 patients had diplopia and 1 patient had enophthalmos. Mean duration after trauma to the surgery was 13.2 days (range, 1–29 days). The mean operative time was 34.1 minutes (range, 10–70 minutes). Four weeks after operation, the nasal packing was removed at an outpatient clinic, with minimal pain, discomfort, and bleeding and no evidence of infection or inflammation. A computed tomography scan performed at 3 months postoperatively showed no re-bulging. The computed tomography image of 1 patient showed frontal sinus haziness; the patient had a headache and underwent endoscopic sinus surgery for symptomatic relief. Three patients had diplopia and 1 had enophthalmos at final follow-up. No other major postoperative complications were noted. Merocel in a glove finger packing technique proved itself to be safe and effective after EER for medial BOF.
- Published
- 2021
14. Minimally Invasive Technique to Reduce the Isolated Anterior Wall Fracture of the Frontal Sinus
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Hong-Ryul Jin, Woo Sub Shim, and Hahn Jin Jung
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Anterior wall ,Anterior wall fracture ,Young Adult ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Internal fixation ,Operation time ,030223 otorhinolaryngology ,Reduction (orthopedic surgery) ,Retrospective Studies ,Frontal sinus ,business.industry ,Retrospective cohort study ,030206 dentistry ,General Medicine ,Surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,Forehead ,Frontal Sinus ,business - Abstract
Conventional open reduction and internal fixation of frontal sinus anterior wall fractures are associated with risks of visible scarring and limited access to the nasofrontal duct. The goal of this study was to report the minimally invasive surgical techniques and their results in cases with frontal sinus anterior wall fractures. A retrospective study was performed on 20 consecutive cases of isolated anterior wall fractures of the frontal sinus between July, 2008 and February, 2017. Causes of injury, interval between the injury and operation, and operation time were reviewed. The fractures were reduced using the minimally invasive techniques of endoscopic endonasal reduction or reduction through a small trephination. Anatomical and aesthetic outcomes were evaluated, and postoperative complications were reviewed. The fractures were reduced with endoscopic endonasal techniques in 11 patients and through a small trephination with a minimal incision in the forehead in 9 patients. The fractures were successfully reduced in all cases. The mean follow-up period was 21.2 months, and no postoperative complications were observed. For isolated anterior wall fractures of the frontal sinus, minimally invasive techniques, such as endonasal endoscopic reduction or reduction through a small trephination, are safe and effective options.
- Published
- 2019
15. Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study)
- Author
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Ki Sang Rha, Young Hyo Kim, Joong Saeng Cho, Jong Seung Kim, Sue K. Park, Seokyung An, Seung Sin Lee, Dae Woo Kim, Doo Hee Han, Sungji Moon, Hyo Jin Yim, Woo Sub Shim, Chae Seo Rhee, Dong Young Kim, Jae Min Shin, Kyu-Sup Cho, Jung-Soo Kim, Hwan Jung Roh, Sang-Wook Kim, and Si Whan Kim
- Subjects
medicine.medical_specialty ,Rhinitis allergic ,Breastfeeding ,lcsh:Medicine ,Environment ,Lower risk ,03 medical and health sciences ,0302 clinical medicine ,medicine ,030223 otorhinolaryngology ,Cesarean Section ,Obstetrics ,business.industry ,Vaginal delivery ,lcsh:R ,Odds ratio ,Delivery, Obstetric ,lcsh:Otorhinolaryngology ,Rhinitis, Allergic ,lcsh:RF1-547 ,Confidence interval ,Breast Feeding ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Original Article ,Surgery ,business ,Breast feeding ,Cohort study - Abstract
Objectives There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children. Methods Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. All subjects were divided into AR or non-allergic rhinitis (NAR) groups. Data on environmental factors, mode of delivery and duration of breastfeeding were collected using a questionnaire. Results Compared with short-term breastfeeding (
- Published
- 2019
16. Reduction of Isolated Zygomatic Arch Fractures with Gillies Approach
- Author
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Hahn Jin Jung, Young Su Kim, Dong Keun Shin, and Woo Sub Shim
- Subjects
Orthodontics ,business.industry ,medicine.medical_treatment ,030206 dentistry ,Zygomatic arch fracture ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Otorhinolaryngology ,medicine ,Surgery ,Zygomatic arch ,030223 otorhinolaryngology ,business ,Reduction (orthopedic surgery) - Published
- 2018
17. Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice
- Author
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Doo Hee Han, Young Kyung Ko, Dong-Young Kim, Hahn Jin Jung, Moo Kyun Park, Hyun Jik Kim, Chae Seo Rhee, and Woo Sub Shim
- Subjects
medicine.medical_treatment ,Science ,Mucous membrane of nose ,Immunoglobulin E ,complex mixtures ,Article ,Mice ,medicine ,Respiratory Hypersensitivity ,Animals ,Lung ,House dust mite ,Air Pollutants ,Mice, Inbred BALB C ,Respiratory tract diseases ,Multidisciplinary ,medicine.diagnostic_test ,biology ,business.industry ,Interleukin-17 ,Pyroglyphidae ,Interleukin ,Eosinophil ,respiratory system ,Allergens ,biology.organism_classification ,Rhinitis, Allergic ,Asthma ,respiratory tract diseases ,Experimental models of disease ,Disease Models, Animal ,Nasal Mucosa ,Bronchoalveolar lavage ,Cytokine ,medicine.anatomical_structure ,Immunology ,biology.protein ,Medicine ,Cytokines ,Nasal administration ,Female ,Particulate Matter ,business ,Bronchoalveolar Lavage Fluid - Abstract
Diesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear. Therefore, this study aimed to investigate the effect of DEP exposure on AR using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP. Allergic symptom scores, serum total and HDM-specific immunoglobulins (Igs), eosinophil infiltration in the nasal mucosa, cytological profiles in bronchoalveolar lavage fluid (BALF), and cytokine levels in the nasal mucosa and spleen cell culture were analyzed. Mice co-exposed to HDM and DEP showed increased allergic symptom scores compared with mice exposed to HDM alone. Reduced total IgE and HDM-specific IgE and IgG1 levels, decreased eosinophil infiltration in the nasal mucosa, and increased proportion of neutrophils in BALF were found in mice co-exposed to HDM and DEP. Interleukin (IL)-17A level was found to be increased in the nasal mucosa of the co-exposure group compared with that in the HDM-exposed group. The levels of IL-4, IL-13, interferon-γ, IL-25, IL-33, and TSLP expression showed no difference between the groups with and without DEP treatment. Increased expression of IL-17A in the nasal mucosa may contribute to DEP-mediated exacerbation of AR in HDM-sensitized murine AR model.
- Published
- 2021
18. A Systematic Review of Benefit of Silicone Intubation in Endoscopic Dacryocystorhinostomy
- Author
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Hahn Jin Jung, Min Gyu Kang, Woo Sub Shim, Dong Keun Shin, Joo Yeon Kim, and Ji Eun Lee
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Dacryocystorhinostomy ,Silicones ,Failure ,lcsh:Medicine ,Review ,Cochrane Library ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Silicone ,Randomized controlled trial ,law ,medicine ,Intubation ,030223 otorhinolaryngology ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Postoperative complication ,Stent ,Endoscopy ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,Surgery ,Otorhinolaryngology ,chemistry ,030221 ophthalmology & optometry ,business ,Meta-Analysis - Abstract
Objectives Insertion of a silicone stent during endoscopic dacryocystorhinostomy (DCR) is the most common procedure to prevent rhinostomy closure. It has been claimed that silicone intubation improves the surgical outcomes of endoscopic DCR. However, many reports have documented an equally high success rate for surgery without silicone intubation. Accordingly, we conducted a systematic review and meta-analysis to clarify the outcomes of endoscopic DCR with and without silicone intubation and determine whether silicone intubation is actually beneficial for patients. Methods PubMed, Embase, and Cochrane Library databases were searched to identify relevant controlled trials evaluating endoscopic DCR with and without silicone intubation. The search was restricted to English articles published between January 2007 and December 2016. Relevant articles were reviewed to obtain information pertaining to interventions and outcomes. We also performed a meta-analysis of the relevant literature. Results In total, 1,216 patients included in 12 randomized controlled trials were pooled. A total of 1,239 endoscopic DCR procedures were performed, and silicone stents were used in 533 procedures. The overall success rate for endoscopic DCR was 91.9% (1,139/1,239), while the success rates with and without silicone intubation were 92.9% (495/533) and 91.2% (644/706), respectively. There was no statistically significant heterogeneity among the included studies. A meta-analysis using a fixed-effects models showed no significant difference in the success rate between endoscopic DCR with silicone intubation and that without silicone intubation (OR, 1.38; 95% CI, 0.89 to 2.12; P=0.148; z=1.45). Furthermore, there were no significant differences with regard to surgical complications such as synechia, granulation, and postoperative bleeding. Conclusion The findings of our meta-analysis suggest that the success rate and postoperative complication rate for endoscopic DCR is not influenced by the use of silicone intubation during the procedure.
- Published
- 2018
19. Corrective Septorhinoplasty in Acute Nasal Bone Fractures
- Author
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Hahn Jin Jung, Jisung Kim, and Woo Sub Shim
- Subjects
medicine.medical_specialty ,Visual analogue scale ,medicine.medical_treatment ,lcsh:Medicine ,030230 surgery ,Osteotomy ,Rhinoplasty ,03 medical and health sciences ,0302 clinical medicine ,medicine ,In patient ,Nasal Bone ,030223 otorhinolaryngology ,Reduction (orthopedic surgery) ,Fracture type ,business.industry ,lcsh:R ,Nasal bone ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,Surgery ,Bone Fractures ,Otorhinolaryngology ,Concomitant ,Original Article ,business - Abstract
OBJECTIVES Closed reduction is generally recommended for acute nasal bone fractures, and rhinoplasty is considered in cases with an unsatisfactory outcome. However, concomitant rhinoplasty with fracture reduction might achieve better surgical outcomes. This study investigated the surgical techniques and outcomes in patients who underwent rhinoplasty and fracture reduction concomitantly, during the acute stage of nasal bone fracture. METHODS Forty-five patients who underwent concomitant rhinoplasty and fracture reduction were enrolled. Nasal bone fractures were classified into three major types (type I, simple fracture; type II, fracture line that mimics nasal osteotomy; and type III, comminuted fracture) based on computed tomography images and preoperative facial images. Two independent otolaryngology-head and neck surgeons evaluated the surgical outcomes and telephone based survey were made to evaluate patients satisfaction. RESULTS Among 45 patients, there were 39 males and 6 females. Type I was the commonest type of fracture with 18 patients (40%), while the most frequently used surgical technique for corrective surgery was dorsal augmentation with 44 patients (97.8%). The mean visual analogue scale satisfaction score of the surgeons and patients were 7.62 and 8, respectively, with no significant differences between fracture types. CONCLUSION Concomitant rhinoplasty with fracture reduction can be performed for acute nasal bone fracture patients, and it might lead to better aesthetic outcomes.
- Published
- 2018
20. Clinicopathological and Radiological Features of Chronic Rhinosinusitis with Eosinophilic Mucin in Chungcheong Province of Korea
- Author
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Soo Kyoung Park, Ki Sang Rha, Hahn Jin Jung, Woo Sub Shim, Ji-Hun Mo, Yong Min Kim, Byoung Joon Baek, and Ki Wan Park
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Allergy ,Veterinary (miscellaneous) ,030106 microbiology ,Disease ,medicine.disease_cause ,Applied Microbiology and Biotechnology ,Microbiology ,Gastroenterology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Medical microbiology ,Internal medicine ,Eosinophilic ,medicine ,Humans ,Sinusitis ,Retrospective Studies ,Korea ,business.industry ,fungi ,Mucin ,Mucins ,Immunoglobulin E ,Middle Aged ,medicine.disease ,Eosinophils ,Treatment Outcome ,Mycoses ,Radiological weapon ,Allergic response ,Chronic Disease ,Female ,business ,Tomography, X-Ray Computed ,Agronomy and Crop Science - Abstract
Chronic rhinosinusitis (CRS) with eosinophilic mucin is considered rare in Korea. The object of this study was to categorize CRS patients with eosinophilic mucin into several groups and compared the groups based on their clinicopathological and radiological features. In total, 105 CRS patients with eosinophilic mucin from four tertiary medical centers which are located at Chungcheong province of Korea were included for this study. The patients were divided into four groups for analysis, based on the presence or absence of an allergy (A) to a fungus or fungal element (F) in the mucin. The following were the four groups: allergic fungal rhinosinusitis (AFRS, A+F+), AFRS-like sinusitis (A+F−), eosinophilic fungal rhinosinusitis (EFRS, A−F+), and eosinophilic mucin rhinosinusitis (EMRS, A−F−). Their clinical manifestation, the presence of associated disease, radiological finding, treatment, and treatment outcome were reviewed and compared. There were no patients in the AFRS-like sinusitis group, 47 patients were assigned to the AFRS group, 27 to the EFRS group, and 41 to the EMRS group. Patients of AFRS group showed a significantly higher association with allergic rhinitis than did the other groups. The mean total serum IgE level in the AFRS patients was significantly higher than in the EFRS and EMRS patients. In the AFRS group and EFRS group, 67.6% and 74.1% had unilateral disease, respectively, in contrast to the EMRS group (4.9%). The mean Hounsfield unit values of the area of high attenuation in the AFRS patients were significantly higher than those in the other groups. Significant clinicopathological differences existed among the subgroups of CRS with eosinophilic mucin. AFRS tends to be an allergic response to colonizing fungi in atopic individuals. In EFRS, local allergies to fungi might play a role in the disease. EMRS is thought to be unconnected with fungal allergies, and it showed different form compared with the AFRS and EFRS groups.
- Published
- 2018
21. Effect of a Chitosan Gel on Hemostasis and Prevention of Adhesion After Endoscopic Sinus Surgery
- Author
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Je-Yeob Yeon, Se-Young An, Ji-Hun Mo, Woo Sub Shim, and Young-Jun Chung
- Subjects
medicine.medical_specialty ,Adverse Effects ,lcsh:Medicine ,Chitosan ,Endoscopy ,Wound Healing ,Hemostasis ,Adhesion (medicine) ,macromolecular substances ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,030223 otorhinolaryngology ,Adverse effect ,medicine.diagnostic_test ,business.industry ,lcsh:R ,technology, industry, and agriculture ,lcsh:Otorhinolaryngology ,medicine.disease ,lcsh:RF1-547 ,Surgery ,carbohydrates (lipids) ,Endoscopic sinus surgery ,Otorhinolaryngology ,chemistry ,Carboxymethyl-chitosan ,030220 oncology & carcinogenesis ,Original Article ,business ,Wound healing - Abstract
Objectives Postoperative bleeding and adhesion formation are the two most common complications after endoscopic sinus surgery (ESS). The former sometimes can be life threatening and the latter is the most common reason requiring revision surgery. This study was designed to evaluate the effect of newly developed chitosan gel (8% carboxymethyl chitosan, Surgi shield) on hemostasis and wound healing after ESS. Methods A prospective, randomized, double-blind controlled trial was conducted in 33 patients undergoing symmetric ESS. At the conclusion of the operation, Surgi shield was randomly applied on one side of the nasal cavity, with the opposite side acting as control and the bleeding quantity of the surgical field was evaluated every 2 minutes. And then, Merocel was placed in the ethmoidectomized areas of the both sides. Five milliliters of Surgi shield was applied to the Merocel of intervention side and saline was applied to the other side. Merocel in both nasal cavities was removed and 5 mL of Surgi shield was applied again to the intervention side on the second day after surgery. The nasal cavity was examined using a nasal endoscope and the degree of adhesion, crusting, mucosal edema, infection, and granulations were graded at 1, 2, and 4 weeks after surgery. Results Complete hemostasis was rapidly achieved in the Surgi shield applied side compared with the control side at 2, 4, 6, 8, and 10 minutes after application of Surgi shield (P#x0003d;0.007, P#x0003d;0.004, P0.05). No adverse effects were noted in the patient series. Conclusion Surgi shield containing chitosan can be used safely to achieve rapid hemostasis immediately after ESS and to prevent adhesion formation.
- Published
- 2016
22. A Case of Bilateral Pneumoparotid Improved with Conservative Treatment
- Author
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Jeong Marn Kim, Yun Seok Oh, Woo Sub Shim, and Hahn Jin Jung
- Subjects
Conservative treatment ,medicine.medical_specialty ,business.industry ,Pneumoparotid ,medicine ,business ,Surgery - Published
- 2017
23. Epiphora after nasolacrimal duct fracture in patients with midfacial trauma
- Author
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Min Jai Cho, Jisung Kim, Woo Sub Shim, and Hahn Jin Jung
- Subjects
Facial trauma ,medicine.medical_specialty ,Facial bone ,Nasolacrimal duct ,business.industry ,medicine.medical_treatment ,Medical record ,Dacryocystorhinostomy ,Retrospective cohort study ,General Medicine ,medicine.disease ,eye diseases ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Etiology ,Medicine ,In patient ,sense organs ,030212 general & internal medicine ,business - Abstract
The aim of this study was to identify the factors related to occurrence of epiphora or requirement of dacryocystorhinostomy (DCR) in patients with midfacial trauma.We performed a retrospective analysis of the medical records of 1038 patients with midfacial trauma from January 2005 to December 2015. Fifty-one patients (55 cases) diagnosed with nasolacrimal duct (NLD) fracture using facial bone computed tomography were enrolled. Correlation analysis was performed of patient- and injury-related factors, including age, sex, facial trauma etiology, accompanying injury, type and level of the NLD fracture, and time from injury to initial surgery, with the occurrence of epiphora and requirement for DCR.Epiphora occurred in 14.5% and DCR was performed in 5.5% of the patients with NLD fracture. The correlation analysis revealed no significant relationship among the factors with the occurrence of epiphora and requirement for DCR.In patients with midfacial trauma and NLD fracture, epiphora occurred in 14.5% and endoscopic DCR was performed due to persistent epiphora in 5.5% and its result was all successful.
- Published
- 2019
24. Management of Dental Implant Related Maxillary Sinusitis
- Author
-
Woo Sub Shim
- Subjects
business.industry ,medicine.medical_treatment ,Medicine ,Dentistry ,General Medicine ,business ,Sinusitis ,medicine.disease ,Dental implant - Published
- 2014
25. Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus
- Author
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Eun-Ha Kim, Young Ki Choi, Moon-Hee Sung, Woo-Sub Shim, Richard J. Webby, Ok-Jun Lee, Chul-Joong Kim, Se Mi Kim, Su-Jin Park, Philippe Noriel Q. Pascua, Gyo-Jin Lim, Eun-Ji Choi, Young-Jae Si, In-Pil Mo, Sun-Woo Yoon, Robert G. Webster, Hyeok-il Kwon, Si-Wook Kim, Yeonji Bae, Yong Taik Lim, and Young-Il Kim
- Subjects
genetic evolution ,Epidemiology ,viruses ,Immunology ,Reassortment ,avian influenza virus ,Biology ,medicine.disease_cause ,Microbiology ,Genome ,Virus ,migratory waterfowl ,Virology ,Drug Discovery ,Pandemic ,medicine ,virus diseases ,Outbreak ,General Medicine ,Influenza A virus subtype H5N1 ,Titer ,HPAI A(H5N8) ,Infectious Diseases ,Tissue tropism ,Original Article ,reassortment ,Parasitology ,migratorywaterfowl - Abstract
The endemicity of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in Asia has led to the generation of reassortant H5 strains with novel gene constellations. A newly emerged HPAI A(H5N8) virus caused poultry outbreaks in the Republic of Korea in 2014. Because newly emerging high-pathogenicity H5 viruses continue to pose public health risks, it is imperative that their pathobiological properties be examined. Here, we characterized A/mallard duck/Korea/W452/2014 (MDk/W452(H5N8)), a representative virus, and evaluated its pathogenic and pandemic potential in various animal models. We found that MDk/W452(H5N8), which originated from the reassortment of wild bird viruses harbored by migratory waterfowl in eastern China, replicated systemically and was lethal in chickens, but appeared to be attenuated, albeit efficiently transmitted, in ducks. Despite predominant attachment to avian-like virus receptors, MDk/W452(H5N8) also exhibited detectable human virus-like receptor binding and replicated in human respiratory tract tissues. In mice, MDk/W452(H5N8) was moderately pathogenic and had limited tissue tropism relative to previous HPAI A(H5N1) viruses. It also induced moderate nasal wash titers in inoculated ferrets; additionally, it was recovered in extrapulmonary tissues and one of three direct-contact ferrets seroconverted without shedding. Moreover, domesticated cats appeared to be more susceptible than dogs to virus infection. With their potential to become established in ducks, continued circulation of A(H5N8) viruses could alter the genetic evolution of pre-existing avian poultry strains. Overall, detailed virological investigation remains a necessity given the capacity of H5 viruses to evolve to cause human illness with few changes in the viral genome.
- Published
- 2014
26. Management of Orbital Blowout Fractures: ENT Surgeon's Perspective
- Author
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Hahn Jin Jung and Woo Sub Shim
- Subjects
Diplopia ,medicine.medical_specialty ,business.industry ,Enophthalmos ,General surgery ,Perspective (graphical) ,medicine ,medicine.symptom ,business ,Orbital Fracture ,medicine.disease ,ENT surgeon ,Orbital blowout fracture - Published
- 2019
27. Prevalence of Ocular Symptoms in Patients with Allergic Rhinitis: Korean Multicenter Study
- Author
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Kun Hee Lee, Cho Ks, Ji Sang Park, Eun Joong Kim, Hun Jong Dhong, Ki Sang Rha, Byung Hoon Ahn, Tae Hoon Lee, Hyun Jun Kim, Sung Wan Kim, Yil Seob Lee, Woo Sub Shim, Chang Hoon Kim, Ji Eun Lee, Soo Hwan Kim, Young Ho Jung, Kyong Rae Kim, Dong Joon Park, Yong-Dae Kim, Dongyoung Kim, Hwan Jung Roh, Kyung-Su Kim, Jae Hoon Lee, Jun Myung Kang, Sang Chul Lim, and Chae Seo Rhee
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Rhinitis, Allergic, Perennial ,Eye Diseases ,genetic structures ,Disease ,Young Adult ,Sex Factors ,Quality of life ,Sex factors ,Surveys and Questionnaires ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,In patient ,Young adult ,Asthma ,Korea ,business.industry ,Disease progression ,Rhinitis, Allergic, Seasonal ,General Medicine ,Middle Aged ,medicine.disease ,eye diseases ,Otorhinolaryngology ,Multicenter study ,Disease Progression ,Quality of Life ,Female ,sense organs ,business - Abstract
Background Allergic rhinitis (AR) is often accompanied by multiple ocular symptoms. This study aimed to evaluate the prevalence of ocular symptoms and the impact of ocular symptoms on the quality of life in patients with AR. Methods One thousand one hundred seventy-four patients with AR were enrolled from 24 centers in Korea. They were classified into four groups according to the Allergic Rhinitis and Its Impact on Asthma (ARIA) guideline and also classified into perennial AR (PAR) and seasonal AR groups. All patients were asked to complete the questionnaire regarding the presence of ocular symptoms, such as eye itching, watery eyes, and red eyes. The correlation between ocular symptoms and the rest of the quality-of-life areas in the Mini-Rhinoconjunctivitis Quality of Life Questionnaire (Mini-RQLQ) was also asked. Results Seven hundred nineteen (61.2%) of 1174 patients had ocular symptoms. In detail, the numbers of patients with eye itching, watery eyes, red eyes, and other ocular symptoms were 605 (51.5%), 313 (26.7%), 207 (17.6%), and 66 (5.6%), respectively. Female patients (72.5%) complained of ocular symptoms more commonly than male patients (55.1%). The patients with moderate–severe persistent AR showed the highest prevalence of ocular symptoms. The correlation coefficients between ocular symptoms and the rest of the quality-of-life areas in the Mini-RQLQ were statistically significant (p < 0.05). Conclusion Sixty-one percent of Korean AR patients experienced ocular symptoms. The patients who were women and had PAR and more severe AR showed higher prevalence of ocular symptoms. The ocular symptoms might have a significant impact on the quality of life in patients with AR.
- Published
- 2013
28. The effect of xylometazoline spray for expansion of nasal cavity
- Author
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Woo Sub Shim, Sang Hi Park, Young Duck Shin, Jin Ho Bae, Jun Sung Han, and Eunjung Kwon
- Subjects
Nasal cavity ,medicine.medical_specialty ,Epinephrine ,Mucous membrane of nose ,Xylometazoline ,lcsh:RD78.3-87.3 ,Acoustic rhinometry ,medicine ,otorhinolaryngologic diseases ,Nasal intubation ,Clinical Research Article ,Nasotracheal intubation ,business.industry ,respiratory system ,Nasal packing ,Surgery ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,lcsh:Anesthesiology ,Anesthesia ,Nasal administration ,business ,medicine.drug - Abstract
Background During nasotracheal intubation it is important to have proper pretreatment for nasal mucosa constriction and nasal cavity expanding. Nasal packing of epinephrine gauze is widely used as well as xylometazoline. The aim of this study was to compare and evaluate the efficacy of prophylactic intranasal spray of xylometazoline against epinephrine gauze packing in expanding the nasal cavity. Methods Volunteers (n = 32) in their twenties without nasal disease such as septal deviation or rhinitis were enrolled in the study. The more patent nostril in each subject was measured by acoustic rhinometry as the base value. After intranasal spray of xylometazoline, the same nostril was remeasured by same method. Twenty four hours later, intranasal packing of epinephrine gauze was done and the same treatment was done. Subject preferences about the procedures were asked. Results There were significant difference among treatments (base value: 0.582 ± 0.164 cm2, xylometazoline spray: 0.793 ± 0.165 cm2, epinephrine gauze packing: 0.990 ± 0.290 cm2) in acoustic rhinometry. While the epinephrine gauze packing showed more efficient mucosa constriction, subjects preferred xylometazoline spray. Conclusions Even though xylometazoline spray was less effective than epinephrine gauze packing, the simplicity and convenience compensated. In patients undergoing nasotracheal intubation, xylometazoline spray can be an alternative to epinephrine gauze packing.
- Published
- 2013
29. Inverted papilloma of the nasal cavity and paranasal sinuses: A Korean multicenter study
- Author
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Tae Bin Won, Dae Woo Kim, Sung Lyong Hong, Ki Sang Rha, Hwan Jung Roh, Hong Ryul Jin, Kyong Rae Kim, Il Joon Moon, Bong-Jae Lee, Chan Hum Park, Seok Hyun Cho, Kyung-Su Kim, Sung Wan Kim, Seung-Kyu Chung, Dong Young Kim, Woo Sub Shim, Chul Hee Lee, Young Jun Chung, Il Gyu Kang, and Jun Myung Kang
- Subjects
medicine.medical_specialty ,Maxillary sinus ,Nose Neoplasms ,Inverted papilloma ,Republic of Korea ,medicine ,Humans ,Stage (cooking) ,Neoplasm Staging ,Retrospective Studies ,Papilloma, Inverted ,Frontal sinus ,business.industry ,Incidence ,Endoscopy ,Retrospective cohort study ,medicine.disease ,Otorhinolaryngologic Surgical Procedures ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Paranasal sinuses ,Otorhinolaryngology ,Papilloma ,Neoplasm Recurrence, Local ,business ,Paranasal Sinus Neoplasms ,Follow-Up Studies ,Cohort study - Abstract
Objectives/Hypothesis: The study group for sinonasal tumors at the Korean Rhinologic Society analyzed the results of the Korean multicenter experience for sinonasal inverted papilloma (IP) surgeries. Study Design: Multicenter cohort study and retrospective analysis. Methods: In total, 939 patients diagnosed with sinonasal IP treated between 1998 and 2007 at 17 university hospitals were enrolled. Demographic data and information about previous surgeries, the origin and involved site of the tumor, the surgical approach, follow-up duration, recurrence, and the presence of malignancy were collected. There were 361 patients whose follow-up was 3 years is required. Moreover, surgeons should always consider combined approaches to reduce the chances of recurrence.
- Published
- 2012
30. The Surgical Outcome of Endoscopic Dacryocystorhinostomy According to the Obstruction Levels of Lacrimal Drainage System
- Author
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Min Sang Kim, Hyun Ah Kim, Hong Ryul Jin, Jae Kwang Oh, Ji Chul Choi, Young Eun Moon, Woo Sub Shim, and Mi Young Choi
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Dacryocystorhinostomy ,lcsh:Medicine ,Common Canaliculus ,urologic and male genital diseases ,Endoscopic dacryocystorhinostomy ,Subjective improvement ,Lacrimal sac ,Epiphora ,medicine ,Nasolacrimal duct ,Lacrimal duct obstruction ,business.industry ,lcsh:R ,Lacrimal drainage ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,eye diseases ,Surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,Original Article ,sense organs ,business - Abstract
Objectives Many factors influence the outcome of endoscopic dacryocystorhinostomy (DCR). One of the most important prognostic factors is the level of obstruction in the lacrimal drainage system. The main objective of this report is to evaluate both the frequency of obstruction by anatomical region of the lacrimal drainage system on dacryocystography (DCG) and the surgical outcome of endoscopic DCR according to the obstruction level. Methods A retrospective series of 48 patients (60 eyes) who had undergone endoscopic DCR from January 2005 to November 2007 were enrolled. Preoperative evaluation consisted of a standard examination which included lacrimal irrigation, probing, DCG and osteomeatal unit (OMU) computed tomography. Patients were classified into four groups according to the obstruction level on DCG. Surgical outcome was evaluated postoperatively by subjective improvement of epiphora and patent rhinostomy opening on nasal endoscopic exam. Results Of 60 eyes, the levels of obstruction were the common canaliculus in 14 eyes (23.3%), the lacrimal sac in 13 eyes (21.7%), the duct-sac junction in 13 eyes (21.7%) and the nasolacrimal duct (NLD) in 20 eyes (33.3%). The ductsac junction obstruction was treated most successfully (100%), followed by NLD obstruction (90%), common canaliculus obstruction (78.6%) and saccal obstruction (69.2%). Conclusion In patients with lacrimal drainage system obstruction, preoperative evaluation of obstruction level using DCG may be helpful for predicting the surgical outcome of endoscopic DCR. The saccal obstruction may have a worse prognosis than the other obstruction levels.
- Published
- 2009
31. Successful Hemostasis with Recombinant Activated Factor VII in a Patient with Massive Hepatic Subcapsular Hematoma
- Author
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Won Joong Jeon, Dong Ick Shin, Ji Yoon Kim, Ju Hee Lee, Rohyun Sung, Yoon Mi Shin, Hye Won Jeong, Woo Sub Shim, Jang Whan Bae, Soon Kil Kwon, Hee Bok Chae, Il Hun Bae, and Euikeun Seo
- Subjects
Toxic hepatitis ,medicine.medical_specialty ,medicine.medical_treatment ,chemistry.chemical_compound ,medicine ,Coagulopathy ,Platelet ,Hemoperitoneum ,Embolization ,lcsh:RC799-869 ,Subcapsular hematoma ,Factor VII ,biology ,business.industry ,Gastroenterology ,medicine.disease ,Surgery ,Published: February, 2009 ,Recombinant activated coagulation factor VII ,chemistry ,Recombinant factor VIIa ,Hemostasis ,biology.protein ,lcsh:Diseases of the digestive system. Gastroenterology ,medicine.symptom ,business - Abstract
Recombinant activated coagulation factor VII (rFVIIa) is known to be effective in the management of acquired deficiencies of factor VII and platelet function defects. But recently, rFVIIa has been successfully used to treat ongoing bleeding in disseminated intravascular coagulopathy (DIC) condition. The patient reported here was suspected to be suffering from toxic hepatitis on admission. After percutaneous liver biopsy, bleeding occurred and did not stop even after right hepatic artery embolization. The patient developed a severe hemorrhage that resulted in hypovolemic shock, hemoperitoneum, and a massive subcapsular hematoma. The patient then developed DIC due to massive transfusion, as well as acute liver necrosis. The patient was given 400 mug/kg of rFVIIa. Recombinant factor VIIa was administered in an attempt to control the bleeding. This stabilized the hemoglobin levels of the patient. The patient gradually recovered in 4 months. In conclusion, this case suggests that rFVIIa can be successfully used for the hemostasis of uncontrolled bleeding in DIC.
- Published
- 2009
32. Effects of Corticosteroids on Expression of Interleukin-18 in the Airway Mucosa of a Mouse Model of Allergic Rhinitis
- Author
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Jin-Young Min, Yoon Kyung Jeon, Hun-Jong Dhong, Tae Bin Won, Yang-Gi Min, Woo Sub Shim, and Si Whan Kim
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Intraperitoneal injection ,Respiratory Mucosa ,Dexamethasone ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Dexamethasone Sodium Phosphate ,Internal medicine ,medicine ,Animals ,Lymphocytes ,030223 otorhinolaryngology ,Glucocorticoids ,Lung ,Rhinitis ,Mice, Inbred BALB C ,biology ,Inhalation ,business.industry ,Interleukin-18 ,Interleukin ,General Medicine ,Eosinophil ,Nasal Lavage Fluid ,Eosinophils ,Disease Models, Animal ,Nasal Mucosa ,Ovalbumin ,Endocrinology ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,biology.protein ,business ,Bronchoalveolar Lavage Fluid ,Glucocorticoid ,medicine.drug - Abstract
Objectives: In this study, we aimed to investigate the release and response of interleukin (IL)-18 to steroid treatment in a mouse model of allergic rhinitis. Methods: BALB/c mice were sensitized systemically by intraperitoneal injection of ovalbumin and locally by ovalbumin inhalation. Dexamethasone sodium phosphate was given by intraperitoneal injection in the steroid treatment group. Symptom scores, eosinophil counts, and IL-18 concentrations in the nasal and lung lavage fluids were analyzed. Results: The symptom scores and eosinophil counts of the negative control and steroid treatment groups were significantly lower than those of the positive control group (p < .01). The mean IL-18 concentrations in the nasal lavage fluid were not significantly different among the three groups (56.68 ± 9.57, 63.39 ± 8.93, and 64.47 ± 6.83 pg/mL, respectively). The IL-18 concentrations in the lung lavage fluid were significantly different between the positive control group and the steroid treatment group (430.75 ± 154.54 and 69.94 ± 14.26 pg/mL, respectively, p = .028). Conclusions: The IL-18 concentration was found to be increased in the lung lavage fluid, but not in the nasal lavage fluid, in a mouse model of allergic rhinitis. Increased IL-18 concentrations returned toward the previous concentrations after steroid treatment. These results suggest that the roles of IL-18 may be different in the pathogenesis of allergic rhinitis and the pathogenesis of asthma.
- Published
- 2007
33. Value of Lying-Down Nystagmus in the Lateralization of Horizontal Semicircular Canal Benign Paroxysmal Positional Vertigo
- Author
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Ji Soo Kim, Il Joon Moon, Woo Sub Shim, So Young Moon, and Ja Won Koo
- Subjects
Adult ,Male ,medicine.medical_specialty ,Benign paroxysmal positional vertigo ,Supine position ,Horizontal semicircular canal ,Labyrinth Diseases ,Posture ,Nystagmus ,Audiology ,Nystagmus, Pathologic ,Lateralization of brain function ,Horizontal Canal ,Supine Position ,otorhinolaryngologic diseases ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Head turning ,Electronystagmography ,Anatomy ,Middle Aged ,medicine.disease ,Semicircular Canals ,Sensory Systems ,Otorhinolaryngology ,Vertigo ,Female ,sense organs ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Horizontal canal benign paroxysmal positional vertigo is characterized by horizontal direction-changing nystagmus induced by lateral head turning in supine position. According to Ewald's second law, the direction of head turning that creates a stronger response represents the affected side in geotropic nystagmus and the healthy side in apogeotropic nystagmus. However, it may not always be possible to lateralize the involved ear only by comparing the intensity of the nystagmus. We studied the values of nystagmus induced by position change from sitting to supine in the lateralization of horizontal canal benign paroxysmal positional vertigo.A retrospective study of 54 patients who had been diagnosed as having horizontal canal benign paroxysmal positional vertigo at the Dizziness Clinic of Seoul National University Bundang Hospital from May 2003 to February 2004 was performed. The directions of the nystagmus induced by lying down were compared with those determined by Ewald's second law.Of the 54 patients, 32 (20 apogeotropic and 12 geotropic) showed horizontal nystagmus induced by lying down. The nystagmus tended to be ipsilesional in apogeotropic patients (80%) and contralesional in their geotropic counterparts (75%).In horizontal canal benign paroxysmal positional vertigo, lying-down nystagmus mostly beats toward the involved ear in the apogeotropic type and directs to the healthy ear in the geotropic type. The direction of lying-down nystagmus may help lateralizing the involved ear in horizontal canal benign paroxysmal positional vertigo.
- Published
- 2006
34. Effects of staphylococcal enterotoxin on ciliary activity and histology of the sinus mucosa
- Author
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Yong Min Kim, Seung Jun Oh, Hun-Jong Dhong, Chae-Seo Rhee, Tae-Bin Won, Woo Sub Shim, Yang-Gi Min, and Jin-Young Min
- Subjects
Staphylococcus aureus ,Micrococcaceae ,Mucociliary clearance ,Enterotoxin ,In Vitro Techniques ,medicine.disease_cause ,Pathogenesis ,Enterotoxins ,medicine ,Animals ,Edema ,Cilia ,Sinusitis ,biology ,Toxin ,Histology ,General Medicine ,Maxillary Sinus ,Maxillary Sinusitis ,biology.organism_classification ,medicine.disease ,Eosinophils ,Nasal Mucosa ,Otorhinolaryngology ,Mucociliary Clearance ,Immunology ,Rabbits - Abstract
The results of our study suggest that Staphylococcus aureus enterotoxin A (SEA) may play an important role in the pathogenesis of rhinosinusitis by ciliostatic effects at high concentrations, and by a different mechanism at low concentrations.To investigate the in vitro effects of SEA on ciliary activity and its in vivo effects on histology of the sinus mucosa.The in vitro effects of SEA on ciliary activity at different concentrations and exposure time were investigated using maxillary sinus mucosa harvested from experimental rabbits. After in vivo instillation of different concentrations (high and low dose) of SEA into the maxillary sinus, ciliary beat frequency (CBF) and histologic findings of the maxillary sinus mucosa were examined.After exposure to low doses of SEA (0.03 and 0.3 ng/ml), CBF did not decrease, but after exposure to high doses of SEA (1.5, 3, and 30 ng/ml), CBF decreased significantly as a function of time. At 24 h after instillation of high-dose SEA (30 ng/ml) into the sinus, CBF decreased significantly and rhinosinusitis was induced after 7 days. Although no alteration was observed in the CBF of the sinus mucosa after instillation of low-dose SEA (0.3 ng/ml), histological findings of rhinosinusitis including subepithelial edema and inflammatory cell infiltration were observed.
- Published
- 2006
35. Cochlear Implantation in Patients with a History of Chronic Otitis Media
- Author
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Woo Sub Shim, Hyo-Jeong Lee, Chong-Sun Kim, Young Ho Kim, Seung Ha Oh, and Sun O Chang
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Chronic otitis ,Cochlear implant ,medicine ,Humans ,In patient ,Cochlear implantation ,Aged ,Retrospective Studies ,Tympanic Membrane Perforation ,Aged, 80 and over ,business.industry ,Soft tissue ,General Medicine ,Middle Aged ,Cochlear Implantation ,Surgery ,Radiography ,Otitis Media ,Cochlear Implants ,Treatment Outcome ,Otorhinolaryngology ,Chronic Disease ,Female ,Tympanomastoidectomy ,Complication ,business ,Algorithms - Abstract
To propose management options for cochlear implantation in chronic otitis media based on our experiences.A retrospective review of 418 cochlear implantations performed by the 2 senior authors between November 1988 and February 2004 was conducted. Nine patients who had chronic otitis media in the ear to be implanted were included. Of these, three showed active inflammation at presentation; the other six cases had undergone previous tympanomastoidectomy surgery and did not show active inflammation at presentation.Five patients with active inflammation or without an adequate soft tissue layer in the mastoid bowl underwent a two-stage procedure. Four cases who showed inactive inflammation and had an adequate tissue layer to protect the electrode array underwent a single-stage technique, although two of them showed dry tympanic membrane perforation. No local or intracranial inflammation recurred. The electrode was exposed in the mastoid bowl in one case, who was managed with revisional mastoid obliteration with soft tissue.Complete eradication of inflammation and the securing of a strong protective soft tissue layer over the electrode are prerequisites for cochlear implantation in ears with chronic otitis media.
- Published
- 2004
36. Endoscopic dacryocystorhinostomy with canalicular marsupialization in common canalicular obstruction
- Author
-
Mi-Young Choi, Dong Wook Kim, and Woo Sub Shim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Dacryocystorhinostomy ,Canalicular obstruction ,Endoscopic dacryocystorhinostomy ,Young Adult ,medicine ,Intubation ,Humans ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Stent ,Retrospective cohort study ,Endoscopy ,General Medicine ,Middle Aged ,Marsupialization ,Surgery ,Ophthalmology ,Treatment Outcome ,Tears ,Female ,Stents ,Radiology ,business ,Nasolacrimal Duct - Abstract
Objective To evaluate the surgical outcomes of endoscopic dacryocystorhinostomy with canalicular marsupialization (EDCR CM) in common canalicular obstruction. Design Retrospective review of medical records. Participants Thirty-six patients (38 eyes) who had undergone EDCR CM for chronic epiphora caused by common canalicular obstruction. Methods Surgical outcomes were evaluated postoperatively by improvement of subjective symptoms and patency of the neo-ostium of DCR on nasal endoscopy. Results Subjective symptoms improved in 81.6% (31/38) after primary EDCR CM and 94.7% (36/38) after revision surgery. In cases of silicone stent intubation, the surgical results were relatively superior compared with patients without silicon stent insertion (83.3% and 75.0%, respectively; p = 0.624). On postoperative nasal examination after primary surgery, the patency of dacryocystorhinostomy site was lower in patients with silicone stent insertion than those without (86.70% and 100%, respectively; p = 0.560), and the patency rate of the canalicular neo-ostium was higher in patients with silicone stent insertion than those without (90.0% and 75.0%, respectively; p = 0.279). There were no serious intraoperative complications except mild punctual erosion (4 patients, 10.5%). Conclusion EDCR CM showed favourable surgical outcomes and few surgical complications. This surgical treatment could be the first-line treatment for patients with distal common canalicular obstruction.
- Published
- 2012
37. Endoscopic dacryocystorhinostomy without silicone stent
- Author
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Woo Sub Shim and Je Yeob Yeon
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Silicones ,Canalicular obstruction ,Endoscopic dacryocystorhinostomy ,chemistry.chemical_compound ,Silicone ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Nasolacrimal duct ,business.industry ,Stent ,Endoscopy ,General Medicine ,Middle Aged ,equipment and supplies ,medicine.disease ,eye diseases ,Lacrimal sac ,Surgery ,Nasolacrimal duct obstruction ,medicine.anatomical_structure ,Treatment Outcome ,Otorhinolaryngology ,chemistry ,Symptom improvement ,Female ,Stents ,sense organs ,business ,Dacryocystorhinostomy ,Nasolacrimal Duct ,Follow-Up Studies - Abstract
In nasolacrimal duct (NLD) obstruction patients that undergo endoscopic dacryocystorhinostomy (DCR), creation of a patent rhinostomy with adequate epithelialization can be accomplished without a stent. However, in common canalicular obstruction patients, a silicone stent seems to have a beneficial role and to bear more favorable results.The aim of this study was to evaluate the surgical outcome of endoscopic DCR without the use of a silicone stent.In all, 36 patients (41 eyes) who underwent endoscopic DCR were enrolled in this study. The patients were classified into a DCR with silicone stent group and a DCR without silicone stent group. Then each of the groups was subdivided into common canalicular obstruction group and NLD obstruction group. Surgical outcomes were evaluated by postoperative symptom improvement and patency of the rhinostomy under nasal endoscopic exam.The epiphora was improved in 84.2% of the silicone stent group and 81.8% of the non-silicone stent group. Categorized by the level of obstruction, in common canalicular obstruction, the success rate was 84.5% (11/13) in the silicone stent group and 57.1% (4/7) in the no stent group. In NLD obstruction, the success rate was 83.0% (5/6) in the silicone stent group and 93.3% (14/15) in the no stent group.
- Published
- 2012
38. The role of transesophageal echocardiography during surgery for patients with tetralogy of Fallot
- Author
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Soo Jin Kim, Woo Sub Shim, Jinyoung Song, Sin-Ae Park, Eun Young Choi, and Sangyoon Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,Diagnostic methods ,Adolescent ,Young Adult ,Monitoring, Intraoperative ,Republic of Korea ,medicine ,Humans ,Cardiac Surgical Procedures ,Child ,Tetralogy of Fallot ,Retrospective Studies ,business.industry ,Medical record ,Infant, Newborn ,Infant ,Retrospective cohort study ,Vascular surgery ,Middle Aged ,medicine.disease ,Cost savings ,Cardiac surgery ,Surgery ,Survival Rate ,Treatment Outcome ,Bypass surgery ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,human activities ,Echocardiography, Transesophageal - Abstract
Routine use of intraoperative transesophageal echocardiography (TEE) is a safe monitoring and diagnostic method during pediatric congenital cardiac surgery. However, the question of whether intraoperative TEE is accurate and cost effective for patients with tetralogy of Fallot (TOF) has not been raised. This study aimed to analyze the cost-benefit of routine TEE during the repair of TOF. The medical records, including TEE results, for patients who underwent correction of TOF between January 1997 and June 2007 were reviewed and retrospectively analyzed. Intraoperative TEE was performed for 340 patients (85 %). Residual problems were detected in 17.9 % (61/340), and a return to bypass was needed for 10 % (34/340) of the patients. The degree of agreement between the intraoperative TEE and early postoperative transthoracic echocardiography (TTE) was relatively high. Surgeons with less surgical experience more frequently used intraoperative TEE (p = 0.007) and performed repeat bypass surgery at a higher rate (p = 0.00). Even relatively unskilled surgeons might be able to achieve surgical outcomes similar to those of experienced surgeons using intraoperative TEE. By avoiding late surgical revision, the possible cost savings were estimated to be 1,726,000 Korean won (US$1,489) per TEE examination. Intraoperative TEE can be used as a tool for surgeons in making decisions in the operating room. In addition, intraoperative TEE decreased the frequency of reoperations and postoperative interventions. The results of this study demonstrate that routine intraoperative TEE during repair of TOF was both clinically beneficial and cost effective.
- Published
- 2012
39. Induction of airway remodeling of nasal mucosa by repetitive allergen challenge in a murine model of allergic rhinitis
- Author
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Chae-Seo Rhee, Tae-Bin Won, Yune Sung Lim, Woo Sub Shim, Jeong-Whun Kim, Yong Min Kim, Yang-Gi Min, and Chul Hee Lee
- Subjects
Pulmonary and Respiratory Medicine ,Allergy ,Pathology ,medicine.medical_specialty ,Ovalbumin ,Immunology ,Anti-Inflammatory Agents ,Mucous membrane of nose ,Dexamethasone ,Mice ,Fibrosis ,Transforming Growth Factor beta ,medicine ,Hypersensitivity ,Immunology and Allergy ,Animals ,Lung ,Rhinitis ,Mice, Inbred BALB C ,Tissue Inhibitor of Metalloproteinase-1 ,biology ,business.industry ,respiratory system ,Allergens ,medicine.disease ,Immunohistochemistry ,respiratory tract diseases ,Nasal Mucosa ,medicine.anatomical_structure ,Matrix Metalloproteinase 9 ,biology.protein ,Nasal Lavage Fluid ,Airway ,business ,medicine.drug - Abstract
Background Although many studies regarding airway remodeling in asthma have been reported, only a few studies have investigated airway remodeling in allergic rhinitis. Objectives To determine whether repetitive allergen challenge could induce airway remodeling in the nose and evaluate the effect of steroids using a murine model of allergic rhinitis. Methods To develop a mouse model of airway remodeling, ovalbumin-sensitized mice were repeatedly exposed to inhaled ovalbumin administration twice a week for 1 month and 3 months. Matched control mice were challenged with phosphate-buffered saline, and the treatment group received intraperitoneal dexamethasone injection. Trichrome, periodic acid–Schiff, hematoxylin-eosin, and immunohistochemical staining against matrix metalloproteinase 9 and tissue inhibitors of metalloproteinase 1 were performed to nasal and lung tissues, and the level of transforming growth factor β in the nasal lavage fluid was analyzed. Results Repetitive ovalbumin challenge for 3 months induced circumferential peribronchial fibrosis in the lung. In the nose, subepithelial fibrosis, increased matrix metalloproteinase 9 and tissue inhibitors of metalloproteinase 1 expression, goblet cell hyperplasia, and submucous gland hypertrophy were observed compared with the control group. Features of airway remodeling were more prominent in the lung tissue. Administration of dexamethasone significantly inhibited these histologic changes. Conclusion Airway remodeling associated with long-term allergen challenge can occur in the nasal mucosa and the lung. Steroid treatment prevents airway inflammation in response to acute allergen challenge, as well as airway remodeling by long-term allergen challenge.
- Published
- 2007
40. Two Cases of Combined Orbital Fractures Involving Medial Wall, Inferior Wall and Inferomedial Strut
- Author
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Jae Hong Park, Yun Seok Oh, Je Yeob Yeon, and Woo Sub Shim
- Subjects
medicine.medical_specialty ,Otorhinolaryngology ,medicine.diagnostic_test ,business.industry ,Medial wall ,Inferior wall ,Medicine ,Surgery ,Anatomy ,Radiology ,Orbital Fracture ,business ,Endoscopy - Published
- 2015
41. Adenoid cystic carcinoma of the sinonasal tract: treatment results
- Author
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Yang-Gi Min, Yong Min Kim, Myung-Whun Sung, Chul Hee Lee, Tae-Bin Won, Chae-Seo Rhee, Woo Sub Shim, Kwang Hyun Kim, and Jeong-Whun Kim
- Subjects
Male ,medicine.medical_specialty ,Maxillary sinus ,Adenoid cystic carcinoma ,Nose Neoplasms ,Metastasis ,Ethmoid Sinus ,Carcinoma ,medicine ,Humans ,Radical surgery ,Neoplasm Metastasis ,Survival rate ,Retrospective Studies ,business.industry ,Nasopharyngeal Neoplasms ,Sinonasal Tract ,Maxillary Sinus ,Middle Aged ,medicine.disease ,Prognosis ,Carcinoma, Adenoid Cystic ,Surgery ,Survival Rate ,Paranasal sinuses ,medicine.anatomical_structure ,Otorhinolaryngology ,Female ,Radiotherapy, Adjuvant ,Radiology ,Nasal Cavity ,business ,Paranasal Sinus Neoplasms - Abstract
Objectives: Malignancies arising from the sinonasal tract, which includes the nose, paranasal sinuses, and nasopharynx, are uncommon. Although adenoid cystic carcinoma (ACC) is the second most common cancer occurring in the sinonasal tract, only few studies have been reported. This retrospective review was performed to identify the clinical features and treatment outcomes of sinonasal ACC. Methods: Thirty-five patients diagnosed and treated for ACC of the sinonasal tract were included in this study. Medical records, radiographs, and pathologic slides were retrospectively reviewed. Results: In two thirds of the patients, the maxillary sinus was the site of origin and cribriform was the most common histologic subtype (61%). Seventy-one percent of the patients had advanced disease (T3, T4) at the time of diagnosis. Five-year overall survival rate was 86% and treatment failure occurred in 18 patients (51%). Five-year local recurrence rate and distant metastasis rate were 30% and 25%, respectively. Adjunctive radiotherapy appeared to reduce local recurrence. Presence of distant metastasis correlated with decreased 5-year survival (P = .001). Five-year survival rate after development of distant metastasis or local recurrence were 17% and 58%, respectively. Conclusions: Based on our findings, we suggest that sinonasal ACC be treated by a combined modality of radical surgery followed by postoperative radiation. The prognosis of sinonasal ACC seems to be determined by the presence of distant metastasis.
- Published
- 2006
42. The role of lacrimal stent in endoscopic dacryocystorhinostomy
- Author
-
Woo Sub Shim and Je Yeob Yeon
- Subjects
Lacrimal bone ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Stent ,General Medicine ,Common Canaliculus ,Osteotomy ,Lacrimal sac ,Surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,Maxilla ,Statistical significance ,medicine ,business ,Nose - Abstract
Dear Editor, We are grateful to the questioner for the comments on our manuscript [1]. The correspondent’s first question was about the size of bone resection during endoscopic dacryocystorhinostomy (DCR). I agree that complete bone resection exposing the full length of the lacrimal sac is one of the most important parts affecting the surgical result. The boundaries of complete bone resection are inferiorly from the level of the inferior turbinate, superiorly to the level of the fundus (the level common canaliculus joining to the lacrimal sac), and anteriorly and posteriorly the edge of the lacrimal sac. The bone covering the posterior part of the lacrimal sac is lacrimal bone, which is thin and can be easily fractured and removed with an elevator. The anterior part is the frontal process of the maxilla. After removal of lacrimal bone, we use a rongeur (Koros Osteo-Punch Rongeurs , 2 mm, T. Koros Surgical Instruments Corp., CA, USA) engaging and removing the free edge of the frontal process of the maxilla. However, sometimes there is a limitation in resection of the superior part with the rongeur; then, a diamond DCR bur (High Speed Diamond DCR Bur , 2.5 mm, 20 curved, Medtronic Xomed, Inc., FL, USA) is introduced. The questioner has mentioned articles [2,3] recommending creation of a 15–20 mm antero-posterior diameter osteotomy. Because we do not perform postoperative computed tomography (CT) scans, we have no data on how large we make bone resections in length, but we estimate that it is around 10 mm antero-posteriorly. The articles the questioner has mentioned were based on external DCR, not endoscopic DCR. In endoscopic DCR, because the bone work is performed under direct visualization of the lacrimal sac from the nose, the appropriate amount of bone resection is possible and it is not same for everyone. Several previous articles on endoscopic DCR showed excellent success rates without mentioning such a large size of bone resection, 15–20 mm [4–6]. The second comment was on our surgical results. In the common canalicular obstruction group of our series, the success rate of the no stent group was 57.1%, compared with 84.5% in the stent group. Even though there was no statistical significance, we concluded that the silicone stent group seems to have a higher success rate. Just like the questioner said, the statistical significance would have been reached with a greater sample size. Although there was no statistical significance, we thought that the silicone stent seems to have a beneficial role in common canalicular obstruction. However, we agree with the questioner’s point and have no further comments on this matter. The third criticism concerned the assessment of the surgical outcome. Surgery was considered successful if the patients had marked improvement of preoperative chronic epiphora and endoscopic findings revealing a patent rhinostomy on nasal endoscopy. We used a visual analog scoring system, 0 to 10. Zero stands for no symptom and 10 for the most severe symptom. Every enrolled patient’s preoperative score was more than 5, and ‘marked improvement’ was considered if the score was 2 or less. An objective method like a flow test of fluorescein from the conjunctiva to the nose could have made this study more perfect. However, we still think that the patients’ symptom improvement is the most important part. Again, we thank the questioner for the interest in our manuscript.
- Published
- 2013
43. A Case of Churg-Strauss Syndrome Involving Nasal Cavity
- Author
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Mi Sook Choi, Dong Wook Lee, Woo Sub Shim, and Chul Soon Jang
- Subjects
Nasal cavity ,Pathology ,medicine.medical_specialty ,business.industry ,Emergency department ,Disease ,respiratory system ,Eosinophil ,medicine.disease ,Dermatology ,respiratory tract diseases ,medicine.anatomical_structure ,Otorhinolaryngology ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Eosinophilia ,Surgery ,cardiovascular diseases ,medicine.symptom ,business ,Vasculitis ,Asthma ,Systemic vasculitis - Abstract
Churg-Strauss syndrome is a rare systemic vasculitis occurring in patients with asthma and peripheral eosinophilia. Lungs, skin, and the nervous system are the most common sites of involvement, although many other organs are affected frequently. We report a case of 54-year-old male with a history of asthma and chronic rhinosinusitis who was admitted to the emergency department because of dyspnea and pleural pain. He was diagnosed with Churg-Strauss syndrome based on bronchial asthma, peripheral eosinophilia, pulmonary infiltration, chronic rhinosinusitis, and extravascular eosinophil infiltration. His symptoms were resolved dramatically after treatment with corticosteroids. Allergic rhinitis and chronic rhinosinusitis with or without polyps may be present at the early stage of Churg-Strauss syndrome. Therefore, otolaryngologists may play a pivotal role in making an early diagnosis of this disease.
- Published
- 2014
44. Two Cases of Epiphora Following Le Fort I Osteotomy
- Author
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Dong Wook Lee, Woo Sub Shim, Mi Sook Choi, and Jisung Kim
- Subjects
Autoimmune disease ,medicine.medical_specialty ,Nasolacrimal duct ,Jaw Surgery ,business.industry ,Soft tissue ,medicine.disease ,Le Fort I osteotomy ,Surgery ,Stenosis ,medicine.anatomical_structure ,Otorhinolaryngology ,Sinus disease ,medicine ,business - Abstract
Several conditions can cause acquired nasolacrimal duct (NLD) obstruction. These conditions include involutional stenosis of the NLD that presumably results from unidentified infection or autoimmune disease, dacryolith, sinus disease, naso-orbital fractures following trauma, inflammatory diseases, such as Wegener’s granulomatosis, neoplasm or iatrogenic injuries during endoscopic paranasal sinus surgery. The two jaw surgery (TJS) (i.e., maxillary and mandibular osteotomies) has recently become popular for cosmetic purposes and has become an increasing cause of concern regarding NLD obstruction. However, there have been no previously reported cases of NLD obstruction associated with TJS. The NLD can be damaged by excessively high maxillary osteotomies during TJSs, which can result in epiphora. Furthermore, in the absence of direct damage to the NLD or excessive mobilization of the maxillary bone during TJS, the soft tissues surrounding the Hasner’s valve can cause NLD obstruction. Recently, the authors experienced two cases of NLD obstruction following TJS and report those cases here.
- Published
- 2014
45. Endoscopic Endonasal Reduction of Medial Blow Out Fracture Using Nasopore Forte®
- Author
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Seok Hee Lee, Min Jin Sun, Si Ok Shin, Chul Chang, Dong Wook Lee, Young-Seok Choi, Mi Suk Choi, and Woo Sub Shim
- Subjects
Medial orbital wall ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Transorbital approach ,Blow out ,Surgery ,Endoscopic sinus surgery ,Otorhinolaryngology ,Fracture (geology) ,Medicine ,business ,Reduction (orthopedic surgery) - Abstract
Background and ObjectivesZZBefore the introduction of transnasal endoscopic sinus surgery, transorbital approach with an external incision used to be one of the representative reconstructive surgical repairing method of blow out fracture. The important advantages of transnasal endoscopic technique are magnified direct visualization and easy accessibility to the medial orbital wall. Nasopore Forte ® is a slowly absorbable material and provides excellent durability. The purpose of this study is to evaluate outcomes of endoscopic endonasal reduction (EER) of medial blow out fracture using Nasopore Forte ® . Subjects and MethodZZA retrospective study was performed on 26 patients with medial blowout fracture who had undergone EER using Nasopore Forte
- Published
- 2011
46. Nasolacrimal Duct Obstruction Following Midfacial Autologous Fat Injection
- Author
-
Woo Sub Shim and Min Jin Sun
- Subjects
Facial trauma ,medicine.medical_specialty ,Nasolacrimal duct ,business.industry ,medicine.medical_treatment ,Dacryocystorhinostomy ,medicine.disease ,Lacrimal sac ,Dacryocystitis ,Surgery ,Autologous Fat Injection ,Nasolacrimal duct obstruction ,medicine.anatomical_structure ,Otorhinolaryngology ,Paranasal Sinus Diseases ,medicine ,business - Abstract
Received August 13, 2011 Accepted September 27, 2011 Address for correspondence Woo Sub Shim, MD Department of OtolaryngologyHead and Neck Surgery, College of Medicine, Chungbuk National University, 410 Seongbong-ro, Heungdeok-gu, Cheongju 361-763, Korea Tel +82-43-269-6157 Fax +82-43-265-6157 E-mail hwatas@naver.com Epiphora is usually caused by nasolacrimal duct obstruction. The nasolacrimal duct obstruction is related with facial trauma, other nasal or paranasal sinus diseases, or recurrent dacryocystitis. We describe a case of iatrogenic nasolacrimal duct obstruction that occurred secondary to midfacial autologous fat injection. In our case, mal positioned fat tissue was detected on the dacryocystogram to be present in the lacrimal sac and the nasolacrimal duct. They were safely removed during dacryocystorhinostomy. Korean J Otorhinolaryngol-Head Neck Surg 2011;54:802-4 Key WordsZZNasolacrimal duct obstruction ᆞEpiphora ᆞAutologous fat injection.
- Published
- 2011
47. Kawasaki Disease Presenting as Cervical Lymphadenitis and Retropharyngeal Abscess
- Author
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Seok Hee Lee, Sung Su Lee, Hyun Ah Kim, Young Eun Moon, Jae Gwuang Oh, Woo Sub Shim, and Dong Wook Lee
- Subjects
Aspirin ,medicine.medical_specialty ,business.industry ,Medical record ,Retropharyngeal abscess ,Cervical lymphadenitis ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,Refractory ,Cervical lymphadenopathy ,medicine ,Kawasaki disease ,Radiology ,medicine.symptom ,business ,Retropharyngeal space ,medicine.drug - Abstract
Background and Objectives : Kawasaki diseases (KD) sometimes present themselves as cervical lymphadenitis or deep neck infection. These unusual Kawasaki diseases then lead to unnecessary antibiotic therapy or surgical intervention or delaying therapy. The purpose of this study is to determine clinical characteristics of early expressions of atypical Kawasaki diseases presenting as deep neck infection. Subjects and Method : We reviewed the medical records of the 6 patients who had been treated for Kawasaki disease that initially presented as fever and cervical lymphadenitis between March, 2007 and December, 2008. Results : The contrast neck CT scan of four of the cases revealed no ring enhancement but retropharyngeal space fluid collection suggestive of retropharyngeal abscess. The contrast neck CT scan of the other two cases showed homogenous nonsuppurative cervical lymph node enlargement. We administered intravenous antibiotics but patients did not response to them. We then immediately administered intravenous immunoglobulin and aspirin after making the diagnosis of Kawasaki disease. The clinical condition of all the cases improved dramatically with defervescence. Conclusion : The possibility of Kawasaki disease should be considered in the following three situations: first, if the fever is refractory to intravenous antibiotic treatment in the febrile child with cervical lymphadenopathy, secondly, if the neck CT scan reveals a soft tissue swelling with no ring enhancement, and lastly, if the fever subsides dramatically after starting intravenous immunoglobulin and aspirin. Echocardiography should be performed as early as possible.
- Published
- 2010
48. A Case ofStreptococcus salivariusMeningitis in a Patient with Cerebrospinal Fluid Rhinorrhea after Skull Base Fracture
- Author
-
Kyeong Seob Shin, Eun-Jung Kim, Dong Hee Ryu, Il Hun Bae, Byeong Cheol Rim, Bo Ra Son, Dong Ik Shin, Woo Sub Shim, and Seung Young Lee
- Subjects
medicine.medical_specialty ,biology ,business.industry ,medicine.disease ,University hospital ,biology.organism_classification ,humanities ,Surgery ,Cerebrospinal Fluid Rhinorrhea ,Skull base fracture ,Streptococcus salivarius ,Skull fracture ,medicine ,Neurosurgery ,business ,Meningitis - Abstract
A Case of Streptococcus salivarius Meningitis in a Patient with Cerebrospinal Fluid Rhinorrhea after Skull Base Fracture Kyeong Seob Shin, Dong Ik Shin, Woo Sub Shim, Byeong Cheol Rim, Il Hun Bae, Seung Young Lee, Dong Hee Ryu, Eun Jung Kim, Bo Ra Son Departments of Laboratory Medicine, Neurology, Otorhinolaryngology-Head and Neck Surgery, Neurosurgery, Radiology and Surgery, Chungbuk National University College of Medicine, Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea
- Published
- 2009
49. Non-Functional Parathyroid Adenoma Presenting as a Massive Cervical Hematoma: A Case Report
- Author
-
Dong Hwal Kim, Woo Sub Shim, Seung Du Yoo, and In Kyeong Kim
- Subjects
medicine.medical_specialty ,endocrine system diseases ,Non functional ,lcsh:Medicine ,Case Report ,Asymptomatic ,Hematoma ,medicine ,Parathyroid adenoma ,Hyperparathyroidism ,Parathyroid neoplasm ,business.industry ,lcsh:R ,Bone fracture ,lcsh:Otorhinolaryngology ,medicine.disease ,lcsh:RF1-547 ,Dysphagia ,Surgery ,Otorhinolaryngology ,medicine.symptom ,business ,Neck ,hormones, hormone substitutes, and hormone antagonists - Abstract
Parathyroid adenoma usually manifests with symptoms related to hypercalcemia, such as urinary stone and bone fracture. It may also present with asymptomatic hypercalcemia. However, spontaneous cervical hematoma may occur very rarely as a result of extracapsular hemorrhage of a cervical parathyroid adenoma causing acute painful cervical swelling, bruising, dyspnea, hoarseness and dysphagia. We report a 44-year-old woman who manifested as a spontaneous cervical hematoma without any clinical evidence of hyperparathyroidism.
- Published
- 2008
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