6 results on '"Varsha Kumari"'
Search Results
2. Microarray profiling of inflammatory bowel disease
- Author
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Khodiyar, Varsha Kumari
- Subjects
616 ,Medicine - Abstract
In this study of inflammatory bowel diseases (IBD, i.e. Crohn's disease and ulcerative colitis), the gene transcription profile of colonic IBD resection specimens were analysed by oligonucleotide microarray analysis. A total of 33,625 genes were profiled across 23 colonic mucosa samples; 5 involved Crohn's disease, 4 uninvolved Crohn's disease, 5 involved ulcerative colitis, 3 uninvolved ulcerative colitis and 6 samples from macroscopically normal areas of colorectal cancer resections (controls). A number of data-mining tools, encompassing clustering (e.g. hierarchical & K-means) and matrix-based methods were evaluated for the analysis of this microarray data. Mining strategies were formulated, tested and then applied to the data set to identify genes showing interesting and novel expression patterns across the samples. The application of these tools to the data set resulted in the generation of gene expression profiles for Crohn's disease and ulcerative colitis. Genes of interest were annotated using publicly accessible sequence and literature databases. Potential links by previous research in the inflammatory bowel disease field were analysed for selected genes. Common pathways emerging from the annotation effort and potentially linking together several of the genes of interest were investigated. Specifically, the energy deficiency hypothesis proposed by Roediger in 1980 and the relevance of potential cancer and apoptosis related genes were reviewed with regard to the findings.
- Published
- 2002
3. Dietary intake by adolescents from government and private school: A comparative assessment
- Author
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Priti, Neeta Kumari, Sangeeta C. Sindhu, Sapna Dhami, and Varsha Kumari
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Food group ,Government ,Private school ,business.industry ,Nutrition Education ,Environmental health ,Dietary intake ,food and beverages ,Medicine ,24 hour recall ,Dietary pattern ,Jaggery ,business - Abstract
Study was carried out on two hundred school going adolescents, aged between thirteen and seventeen years. Dietary intake of all the subjects was recorded for three consecutive days by ‘24 Hour Recall Method’. Study revealed that the daily mean intake of cereals, pulses, green leafy vegetables, roots tubers, other vegetables, fruits, milk & milk products, fats & oils, and sugar & jaggery was significantly lower (p≤0.05) than the recommended RDIs values in the daily diet of both males and females of both the age group (13-15 years and 16-17 years) of government and private schools. Furthermore, there was significant (p≤0.05) difference between the daily mean dietary intake of government and private school adolescents. Except cereals, pulses, roots & tubers and sugar & jaggery the adequacy ratio was below 50 per cent for all food groups in majority of government school respondents. However, majority of private school respondents met the adequacy by 75 -99.9 per cent of all food groups except green leafy vegetables which was below 50 per cent. In order to improve the current dietary pattern of school going adolescents there is an urgent need of imparting focused nutrition education programmes among the school going youth and their parents.
- Published
- 2021
- Full Text
- View/download PDF
4. Drug utilization pattern of antimicrobial drugs in intensive care unit of a tertiary care hospital attached with a medical college
- Author
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Bansari Patel, Chintan Doshi, Nishita H. Darji, Varsha Kumari, Hiren R. Trivedi, and Rutvij Hedamba
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Drug ,Drug Utilization ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,030206 dentistry ,Tertiary care hospital ,Antimicrobial ,Intensive care unit ,law.invention ,03 medical and health sciences ,Metronidazole ,0302 clinical medicine ,law ,Emergency medicine ,Medicine ,Observational study ,030212 general & internal medicine ,Medical prescription ,business ,Intensive care medicine ,media_common ,medicine.drug - Abstract
Background: A number of antimicrobial drugs are prescribed to the patients in Intensive Care Unit (ICU). Drug utilization research was defined by WHO as the study of marketing, distribution, prescription, and use of drugs in a society, with special emphasis on the resulting medical, social and economic consequences. There is lack of information about the use of antimicrobial agents in the ICU at GGGH till date. So we decided to conduct this type of study. Methods: A prospective observational study was carried out for 12 months. Patients of age >18 of both sexes who was admitted in ICU were included in the study while pregnant and lactating women excluded. The prescribing pattern was analyzed by using World Health Organization basic drug indicators. Results: Among 611 patients, 373 (61.04%) were male and 238 (38.95%) were female. The most common emergency was post-operative 204 (33.38%).The most common prescribed antimicrobial drug group and drug was antiamoebic drugs and metronidazole respectively in 437 (24.04%) out of total drugs prescribed. The numbers of antimicrobial drugs prescribed per patient were 2.97. 68% drugs were prescribed from WHO and national EML list. Total 57.26% drugs were prescribed by generic name. Average antimicrobial drug cost per patient was 1805.34 rs. Conclusions: Despite of limitations of present study it gives important conclusion about how antimicrobial drugs are used in GGGH ICU. This information can be used for improvement of current treatment strategies.
- Published
- 2016
- Full Text
- View/download PDF
5. Increasing rates of cesarean section, an upcoming public health problem: an audit of cesarean section in a tertiary care center of North India based on Robson classification
- Author
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Varsha Kumari, Vinita Das, Anjoo Agarwal, Amita Pandey, Smriti Agrawal, and Namrata Kumar
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medicine.medical_specialty ,Pediatrics ,business.industry ,Section (archaeology) ,Family medicine ,Public health ,medicine ,Center (algebra and category theory) ,Audit ,business ,North india ,Tertiary care - Abstract
Background: Increasing rates of cesarean section during last three decades has become a cause of alarm since and a need for ongoing studies. Objective of present study was to investigate cesarean section rates as per modified Robsons Criteria and to determine area of concern which requires maximum focus to decrease overall caesarean rateMethods: This cross sectional study was conducted over a period of one year (From January 2016 to December 2016) in the Department of Obstetrics and Gynecology at King George’s Medical University, Lucknow.Results: Total number of deliveries for one year was 8526. Out of them, 4275 (50.1%) were vaginal and 4251 (49.9%) were abdominal. Overall maximum caesarean section rate was contributed by group 5 of modified Robsons criteria i.e. previous section, singleton, cephalic, ≥37 weeks (17.7%).Conclusions: Robson 10 group classification provides easy way in collecting information about Cesarean section rate which obtains good insight into certain birth groups. It is important that efforts to reduce the overall CS rate should focus on reducing the primary CS rate (group 1 and 2) and on increasing vaginal birth after CS (group 5). The caesarean rate is commonest in group 5 that is previous section (17.7%).
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- 2017
- Full Text
- View/download PDF
6. Lymphocutaneous sporotrichosis in an adolescent girl presenting as mycetoma
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Ragini Tilak, Manish Bansal, Varsha Kumari, Shyam Sunder Pandey, and Taniya Sharma
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medicine.medical_specialty ,Antifungal Agents ,Adolescent ,Itraconazole ,medicine.drug_class ,media_common.quotation_subject ,Antibiotics ,Biopsy ,medicine ,Sporothrix schenckii ,Humans ,Girl ,Foot Ulcer ,media_common ,medicine.diagnostic_test ,Sporotrichosis ,biology ,business.industry ,Sporothrix ,General Medicine ,Inguinal lymphadenopathy ,medicine.disease ,biology.organism_classification ,Dermatology ,Mycetoma ,Surgery ,Female ,medicine.symptom ,business ,Foot (unit) ,medicine.drug - Abstract
A 13-year-old girl presented with multiple painless purulent ulcers with raised borders on the medial aspect of the sole of her right foot associated with inguinal lymphadenopathy for the past 4 years. There was history of local trauma at the site prior to the formation of ulcers. There were no other significant associated signs or symptoms. The patient was initially treated with multiple antibiotics with minimal improvement. Fungal cultures of biopsy specimens demonstrated the presence of colonies of Sporothrix schenckii thus confirming the diagnosis of sporotrichosis. Oral itraconazole at the dose of 100 mg twice daily was initiated with marked response at 4 weeks. This case demonstrated a rare morphological presentation of the lymphocutaneous sporotrichosis as mycetoma. The possible diagnosis of sporotrichosis should be kept in mind in such a clinical presentation not responding to antibiotics. Cutaneous sporotrichosis should be diagnosed and treated as early as possible because untreated cases may disseminate to cause visceral involvement with fatal outcome in immunocompromised patients.
- Published
- 2012
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