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Supplemental material, sj-pdf-4-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-2-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-pdf-5-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-3-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-pdf-4-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-3-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-1-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-docx-2-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Supplemental material, sj-pdf-5-ejo-10.1177_11206721211034649 for Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires by Luca Cimino, Piergiorgio Neri, Elisabetta Miserocchi, Maria Pia Paroli, Lorenzo Vannozzi, Leonardo Mastropasqua, Caterina Gagliano, Maria Vadalà, Michele Figus, Francesca Romana Florio, Barbara Iaccheri, Paolo Mora, Maurizio Fossarello, Paola Balestrieri, Giuliana Gualberti, Francesca Marando and Massimo Accorinti in European Journal of Ophthalmology

Objectives To investigate the real-life experience of patients affected by neovascular age-related macular degeneration (nAMD), in the healthcare pathway for the management of the disease, using a "patient journey" and narrative method approach. Methods The patient journey of subjects affected by nAMD was designed using a process-mapping methodology involving a team from 11 Italian centres. Subsequently, narratives were collected from nAMD patients and family members. The interviews were analyzed using the narrative medicine methodology. Results Eleven specialized retina centres across Italy were involved and 205 narratives collected. In 29% of cases, patients underestimated their symptoms or attributed them to non-pathological causes, thus delaying the specialist consultation. The delay in accessing to care was due to a lack of awareness of this disease (50% of the participants didn't know what nAMD is) and to critical issues faced at first visit (long waiting lists, failed diagnosis, underestimation of the problem). Despite anti-VEGF therapies were perceived as effective in improving or stabilizing vision in 91% of narratives collected, 77% of patients still reduced or ceased daily activities such as reading and driving. Within the pathway of care there was not a multidisciplinary approach, and the patients were treated just by the ophthalmologist. Conclusions nAMD may significantly affect the quality of life of affected patients, both from a functional and psychological point of view. The narrative medicine approach highlights some critical points in the healthcare journey of nAMD patients and represents a useful background in implementing patient management algorithms and pathways of care.

Background and Objectives: The objective of this paper is to compare the visual outcomes and quality of life (QoL) after bilateral ultrathin Descemet’s stripping automated endothelial keratoplasty (UT-DSAEK) with bilateral penetrating keratoplasty (PK) for Fuchs’ endothelial dystrophy (FED). Materials and Methods: Retrospective comparative cohort study, including 11 patients with FED who underwent bilateral PK and 13 patients with FED who underwent bilateral UT-DSAEK. All patients were already pseudophakic or had undergone a combined cataract procedure. The main outcomes were corrected distance visual acuity (CDVA) corneal higher-order aberrations (HOAs), contrast sensitivity (CS) and quality of life (QoL). Results: The mean follow-up after the second eye surgery was 32.5 ± 10.2 months in PK and 19.6 ± 8.6 months in UT-DSAEK patients. The CDVA in the UT-DSAEK group was significantly better than in the PK one (0.18 ± 0.07 vs. 0.35 ± 0.16 logMAR, p &lt, 0.0001). The mean anterior corneal total HOAs of the central 5 mm were significantly lower in UT-DSAEK eyes than in PK eyes (0.438 ± 0.078 µ and 1.282 ± 0.330 µ respectively, p &lt, 0.0001), whilst the mean posterior total HOAs did not differ between groups (0.196 ± 0.056 µ and 0.231 ± 0.089 µ, respectively, p = 0.253). The CS was lower at 0.75 and 1.5 cycles/degree in P the K group when compared to the DSAEK one (p = 0.008 and 0.005, respectively). The QoL scores by the NEI RQL-42 test exhibited better values in DSAEK patients in 9 out of 13 scales. Conclusion: Our study confirms that UT-DSAEK provides a better visual function in terms of CDVA and CS, together with lower HOAs, when compared to PK. Hence, the vision-related QoL, binocularly evaluated by the NEI RQL-42 items, indicates a higher satisfaction in UT-DSAEK eyes.

Background: The purpose of this study was to evaluate the association between a novel psychometric 12-item questionnaire (U-qest) and other validated questionnaires to assess quality of life and work impairment in patients with non-infectious uveitis. Methods: Data were collected at baseline and 3 months postbaseline using U-qest and two other validated questionnaires: The National Eye Institute 25-Item Visual Function Questionnaire (VFQ-25) and the 12-Item Short-Form Health Survey (SF-12). Results: A total of 136 patients (52.2% female) aged 47.9 ± 14.8 years (mean ± SD) were enrolled in 14 uveitis referral centres. U-qest correlated moderately with VFQ-25 and SF-12 at baseline and at 3 months. Both U-qest and VFQ-25 scores improved as disease improved; however, U-qest also detected improvement in patients for whom VFQ-25 scores did not improve. Disease activity was shown to significantly affect activity impairment. Patients and physicians expressed positive perceptions regarding the use and benefit of this instrument. U-qest showed very good reliability in terms of internal consistency (Cronbach’s alpha = 0.91). Conclusions: U-qest can be considered a useful tool to assess the burden of uveitis on quality of life.

Blindness due to photoreceptor degeneration is observed in both genetic and acquired eye disorders. Long blue light exposure can contribute to increase levels of oxidative compounds within the retinal pigment epithelium (RPE), enhancing risk of retinal damage. In retina, reactive oxygen species contribute to the activation of inflammatory cascade. If chronic, this inflammatory response can result in photoreceptor death. Therefore, we investigated the effects of the endogenous adduct N-retinylidene-N-retinylethanolamine (A2E) on RPE cells, in order to identify the most dysregulated cytokines and their related inflammatory pathways. RPE cells were exposed to A2E and blue light for 3h and 6h. By transcriptome analysis, we identified differentially expressed genes in A2E-treated cells, when compared to untreated ones. Expression values were quantified by the Limma R package. Enrichment analysis was performed according to the “Reactome” and the Gene Ontology databases. Expression of pro-inflammatory cytokines increased after 3h of A2E treatment and pathways related to IL-6 and IL-1 signaling resulted enriched. Also the up-regulation of genes having a protective role against inflammation was observed. Moreover, our results show that ferroptosis could contribute to RPE degeneration induced by A2E and blue light. Dysregulated genes related to retinal degeneration triggered by oxidative damage and inflammatory response activation identified in this study can be considered as potential biomarkers for targeted therapies.

Retinal and choroidal microvascular changes can be related to renal impairment in hypertension and chronic kidney disease (CKD). The study examines the association between retinochoroidal parameters and renal impairment in hypertensive, non-diabetic patients. This is a cross-sectional study on Caucasian patients with systemic arterial hypertension with different levels of renal function. All subjects were studied by blood chemistry, urine examination, microalbuminuria and blood pressure. Complete eye examination was completed with swept source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) scans of macular region. Patients were divided in groups: LowGFR and HighGFR and CKD− and CKD+, according to the value of glomerular filtrate (GFR) and albuminuria. LowGFR and CKD+ groups included patients with clinical kidney impairment. One hundred and twenty eyes of 120 hypertensive patients were evaluated. The mean retinal thickness was thinner in CKD+ versus CKD− group (p

The introduction in the past few years of advanced optical coherence tomography (OCT) techniques has greatly increased our understanding of the choroid, which is the most important vascular layer of the eye. Our study aimed to assess choroidal thickness by using swept-source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without early-stage chronic kidney disease (CKD). We enrolled 100 EHs, of whom 65 were without kidney damage, and 35 had stage 1-3 CKD. In all of the participants, SS-OCT and a routine biochemical workup were performed. Glomerular filtration rate (GFR) was estimated by the CKD Epidemiology Collaboration equation (eGFR). CKD was defined in agreement with the Kidney Disease Outcomes Quality Initiative Kidney Disease: Improving Global Outcomes 2002 guidelines. OCT measurements were performed according to the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol, which divides the macula into nine subfields. The circular grid consists of three concentric rings. EHs with CKD showed thinner choroidal thicknesses than those without it (all p