14 results on '"V. Pucci"'
Number of results to display per page
Search Results
2. Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study
- Author
-
Davide Poli, Eliana Rulli, Luigi Varano, S. Talarico, S. Lateri, Luca Agnifili, C. Gizzi, F. Parravano, Teresa Rolle, E. Maggiolo, P. Vallon, Ilaria Motolese, Andreas Katsanos, S. Marchi, E. Bonacci, O. Vattovani, Luciano Quaranta, V. Pucci, L. Fontana, Francesco Oddone, Lorenza Landi, Luciana Carmassi, Ivano Riva, D. Jannetta, F. Cantatore, A. Bagnis, Carlo Enrico Traverso, Ciro Costagliola, O. Oneta, L. Bossolesi, Ignazio Alberto Zucca, Emilio C. Campos, Giulio Mirabella Roberti, Luca Rossetti, N. Ungaro, V. Tagliavini, A. Cucca, Michele Uva, D. Tognetto, Carlo Sborgia, Roberto Ratiglia, Stefano A. Gandolfi, Giuseppe Giannaccare, Maurizio Fossarello, R. Piccini, Lital Hollander, Gianluca Manni, M. Cassamali, F. Iannacone, R. Scotto, Robert N. Weinreb, M. Musolino, A. Rossi, L. Mastropasqua, T. Carchedi, Valter Torri, Simone Alex Bagaglia, F. Galli, G. Cardarella, Gemma Caterina Maria Rossi, Rulli, E., Quaranta, L., Riva, I., Poli, D., Hollander, L., Galli, F., Katsanos, A., Oddone, F., Torri, V., Weinreb, R. N., Varano, L., Carchedi, T., Talarico, S., Parravano, F., Motolese, I., Bagaglia, S. A., Rossi, G. C. M., Lateri, S., Bossolesi, L., Carmassi, L., Rolle, T., Piccini, R., Ratiglia, R., Rossi, A., Gandolfi, S., Tagliavini, V., Ungaro, N., Fossarello, M., Cucca, A., Zucca, I., Uva, M., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni, G. L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, C., Scotto, R., Musolino, M., Landi, L., Bagnis, A., Rulli, Eliana, Quaranta, Luciano, Riva, Ivano, Poli, Davide, Hollander, Lital, Galli, Fabio, Katsanos, Andrea, Oddone, Francesco, Torri, Valter, Weinreb, Robert N., Fontana, Luigi, Marchi, Susanna, Bagaglia, S.A., Rossi, G.C.M., and Manni, G.L.
- Subjects
Male ,Aging ,Visual acuity ,genetic structures ,lcsh:Medicine ,Glaucoma ,Neurodegenerative ,Eye ,0302 clinical medicine ,Quality of life ,Visual Field Test ,Surveys and Questionnaires ,80 and over ,Surveys and Questionnaire ,Young adult ,lcsh:Science ,Aged, 80 and over ,Multidisciplinary ,Middle Aged ,Visual field ,Open-Angle ,Italy ,Female ,Visual field loss ,medicine.symptom ,Glaucoma, Open-Angle ,Human ,Adult ,medicine.medical_specialty ,glaucoma, quality of life, Visual field ,Open angle glaucoma ,Vision Disorders ,Italian Study Group on QoL in Glaucoma ,and over ,Article ,03 medical and health sciences ,Young Adult ,Clinical Research ,Ophthalmology ,Settore MED/30 ,medicine ,Humans ,Author Correction ,Eye Disease and Disorders of Vision ,Aged ,business.industry ,lcsh:R ,Vision Disorder ,Neurosciences ,medicine.disease ,eye diseases ,Quality of Life ,Visual Field Tests ,Clinical trial ,glaucoma ,quality of life ,030221 ophthalmology & optometry ,lcsh:Q ,business ,030217 neurology & neurosurgery - Abstract
The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or “glaucoma suspect” patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were classified as having VF damage in one eye (VFD-1), both eyes (VFD-2), or neither eye (VFD-0). 3227 patients were enrolled and 2940 were eligible for the analysis. 13.4% of patients were classified in the VFD-0, 23.7% in the VFD-1, and 62.9% in the VFD-2 group. GSS visual symptoms domain (Func-4) and GSS non-visual symptoms domain (Symp-6) scores were similar for the VFD-0 and VFD-1 groups (p = 0.133 and p = 0.834 for Func-4 and Symp-6, respectively). VFD-0 group had higher scores than VFD-2 both in Func-4 (p
- Published
- 2018
3. QUALITY CONTROL OF PHARMACEUTICAL FORMULATIONS OF NEUROLEPTIC DRUGS BY CAPILLARY ZONE ELECTROPHORESIS
- Author
-
Meri Raggi, Ernst Kenndler, and V. Pucci
- Subjects
Chromatography ,Chemistry ,Clinical Biochemistry ,Loxapine ,Pharmaceutical Science ,Repeatability ,Biochemistry ,Dosage form ,Analytical Chemistry ,Dilution ,Electrophoresis ,Capillary electrophoresis ,Ionic strength ,medicine ,Quantitative analysis (chemistry) ,medicine.drug - Abstract
Classical (haloperidol and chlorpromazine) and atypical neuroleptics (olanzapine, clozapine, loxapine, and risperidone) were quantified in pharmaceutical formulations (tablets, capsules, and oral solutions) by capillary zone electrophoresis. The simple sample pretreatment consists of a one-step extraction, filtration, and dilution. The electrophoretic conditions were as follows: uncoated fused-silica capillary (28.3 cm total length, 22.0 cm effective length, 50 μm I.D.), phosphate buffer (pH 2.5, ionic strength 35 mmol/L). The separation voltage (15 kV) results in a current lower than 50 μA. UV detection was performed at 214 nm. Calibration curves were linear in the 5–50 μg/mL range for all tested drugs (r better than 0.999). The repeatability (or intra-day precision), expressed by the relative standard deviation, was better than 2% (6 measurements). The accuracy, resulting from recovery studies, was between 98 and 105 %. The amount of drug found agreed with the declared contents within the limits specifi...
- Published
- 2000
4. Separation of eleven central nervous system drugs by capillary zone electrophoresis
- Author
-
Meri Raggi, V. Pucci, and Ernst Kenndler
- Subjects
chemistry.chemical_classification ,Chromatography ,Cyclodextrin ,Polyvinylpyrrolidone ,Osmolar Concentration ,Central nervous system ,Phosphate buffered saline ,technology, industry, and agriculture ,Electrophoresis, Capillary ,macromolecular substances ,General Chemistry ,Electrolyte ,Hydrogen-Ion Concentration ,medicine.anatomical_structure ,Capillary electrophoresis ,chemistry ,Ionic strength ,Phase (matter) ,medicine ,Spectrophotometry, Ultraviolet ,Central Nervous System Agents ,medicine.drug - Abstract
Several strategies to improve the separation of 11 central nervous system drugs (antipsychotics and antidepressants) with capillary zone electrophoresis were applied: the variation of the pH of the buffering background electrolyte, its ionic strength, addition of inclusion-complex forming beta-cyclodextrin or polyvinylpyrrolidone (PVP), respectively, as a replaceable, soluble, polymeric pseudo-stationary phase. Best separation was achieved at pH 2.5 and 35 mmol/l ionic strength (phosphate buffer), with 0.5% (w/v) PVP.
- Published
- 1999
5. Separation of antipsychotic drugs (clozapine, loxapine) and their metabolites by capillary zone electrophoresis
- Author
-
Maria Augusta Raggi, V. Pucci, and Ernst Kenndler
- Subjects
Loxapine ,Electrolyte ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Electrolytes ,Capillary electrophoresis ,medicine ,Clozapine ,Cyclodextrins ,Chromatography ,Polyvinylpyrrolidone ,Chemistry ,Organic Chemistry ,Osmolar Concentration ,beta-Cyclodextrins ,Electrophoresis, Capillary ,Povidone ,General Medicine ,Amoxapine ,Hydrogen-Ion Concentration ,Phosphate ,Ionic strength ,medicine.drug ,Antipsychotic Agents ,gamma-Cyclodextrins - Abstract
Two antipsychotic drugs (clozapine and loxapine) and six metabolites, N-demethylclozapine, clozapine N-oxide, N-demethylloxapine (amoxapine), 7-hydroxyloxapine, 8-hydroxyloxapine, 8-hydroxyamoxapine, were separated by capillary zone electrophoresis. Variation of pH and ionic strength of the acidic phosphate buffer (pH below 4) did not enable the separation of loxapine and one of its metabolites. Resolution of the single parent drugs and their metabolites was possible in background electrolytes (phosphate, pH 3.5, 60 mmol/l) containing either 0.2% (w/v) polyvinylpyrrolidone as replaceable pseudo-stationary phase, or 0.75 mmol/l beta-cyclodextrin added as complex-forming agent. Full separation of the mixture with baseline resolution of all analytes was obtained with a background electrolyte with heptakis-6-sulfato-beta-cyclodextrin added as negatively charged complexation agent with improved separation selectivity.
- Published
- 1999
6. 397 Noninvasive measurement of coronary flow reserve in the anterior and posterior descending coronary arteries by transthoracic Doppler
- Author
-
V. Pucci, Francesco Romeo, E. Pisani, P. Spedicato, A. Aprile, M Marchei, Paolo Voci, Enrica Mariano, and Francesco Pizzuto
- Subjects
medicine.medical_specialty ,business.industry ,Coronary flow reserve ,General Medicine ,Coronary arteries ,symbols.namesake ,medicine.anatomical_structure ,Internal medicine ,medicine ,symbols ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,Doppler effect - Published
- 2003
7. Contact sensitivity in otitis externa
- Author
-
Paola Nappa, N. Balato, Giuseppe Lembo, Fabrizio Ayala, V. Pucci, Lembo, G, Nappa, P, Balato, Nicola, Pucci, V, and Ayala, Fabio
- Subjects
Staphylococcus aureus ,Tetracaine ,business.industry ,Dermatology ,Dermatitis, Contact ,Otitis Externa ,Contact sensitivity ,Otitis ,Italy ,Anesthesia ,Candida albicans ,Chronic Disease ,medicine ,Humans ,Immunology and Allergy ,Prospective Studies ,medicine.symptom ,business ,medicine.drug
8. Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients
- Author
-
Riva, I, Legramandi, L, Rulli, E, Konstas, Ag, Katsanos, A, Oddone, F, Weinreb, Rn, Quaranta, L, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, Ungaro, N, Fossarello, M, Cuccu, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, G, Iannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, Bagnis, A, Riva I, Legramandi L, Rulli E, Konstas AG, Katsanos A, Oddone F, Weinreb RN, Quaranta L, Italian Study Group on QoL in Glaucoma: L Varano, T Carchedi, S Talarico, F Parravano, I Motolese, SA Bagaglia, GCM Rossi, S Lateri, L Bossolesi, L Carmassi, T Rolle, R Piccini, R Ratiglia, A Rossi, S Gandolfi, V Tagliavini, N Ungaro, M Fossarello, A Cuccu, I Zucca, M Uva, E Bonacci, G Cardarella, D Tognetto, O Vattovani, P Vallon, F Iannacone, L Fontana, S Marchi, GL Manni, D Jannetta, G Roberti, L Rossetti, E Maggiolo, O Oneta, C Sborgia, F Cantatore, L Mastropasqua, L Agnifili, E Campos, C Gizzi, G Giannaccare, V Pucci, M Cassamali, C Costagliola, C Traverso, R Scotto, M Musolino, L Landi, A Bagnis, Riva, Ivano, Legramandi, Lorenzo, Rulli, Eliana, Konstas, Anastasios G, Katsanos, Andrea, Oddone, Francesco, Weinreb, Robert N, Quaranta, Luciano, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, Ungaro, N, Fossarello, M, Cuccu, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.
- Subjects
0301 basic medicine ,Change over time ,medicine.medical_specialty ,Aging ,Visual acuity ,Open angle glaucoma ,genetic structures ,Population ,lcsh:Medicine ,Glaucoma ,Diseases ,Italian Study Group on QoL in Glaucoma ,Neurodegenerative ,Eye ,Article ,03 medical and health sciences ,Medical research ,0302 clinical medicine ,Quality of life ,Clinical Research ,Settore MED/30 ,Internal medicine ,medicine ,POAG ,lcsh:Science ,education ,Prospective cohort study ,Author Correction ,Eye Disease and Disorders of Vision ,education.field_of_study ,Multidisciplinary ,business.industry ,lcsh:R ,Neurosciences ,medicine.disease ,primary open angle glaucoma ,humanities ,eye diseases ,030104 developmental biology ,Symptom perception ,glaucoma ,quality of life ,lcsh:Q ,sense organs ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p
- Published
- 2019
9. Influence of Sociodemographic Factors on Disease Characteristics and Vision-related Quality of Life in Primary Open-angle Glaucoma Patients: The Italian Primary Open Angle Glaucoma Study (IPOAGS)
- Author
-
Riva, Ivano, Legramandi, Lorenzo, Katsanos, Andreas, Oddone, Francesco, Rulli, Eliana, Roberti, Gloria, Quaranta Luciano, Varano L, Carchedi T, Talarico S, Parravano F, Motolese I, Bagaglia SA, Rossi GCM, Lateri S, Bossolesi L, Carmassi L, Rolle T, Piccini R, Ratiglia R, Rossi A, Gandolfi S, Tagliavini V, Ungaro N, Fossarello M, Cucca A, Zucca I, Uva M, Bonacci E, Cardarella G, Tognetto D, Vattovani O, Vallon P, Iannacone F, Fontana L, Marchi S, Manni GL, Jannetta D, Roberti G, Rossetti L, Maggiolo E, Oneta O, Sborgia C, Cantatore F, Mastropasqua L, Agnifili L, Campos E, Gizzi C, Giannaccare G, Pucci V, Cassamali M, Costagliola C, Scotto R, Musolino M, Landi L, Bagnis A., I Riva, L Legramandi, A Katsanos, F Oddone, E Rulli, G Roberti, L Quaranta, Italian Study Group on QoL in Glaucoma: L Varano, T Carchedi, S Talarico, F Parravano, I Motolese, SA Bagaglia, GCM Rossi, S Lateri, L Bossolesi, L Carmassi, T Rolle, R Piccini, R Ratiglia, A Rossi, S Gandolfi, V Tagliavini, N Ungaro, M Fossarello, A Cucca, I Zucca, M Uva, E Bonacci, G Cardarella, D Tognetto, O Vattovani, P Vallon, F Iannacone, L Fontana, S Marchi, GL Manni, D Jannetta, L Rossetti, E Maggiolo, O Oneta, C Sborgia, F Cantatore, L Mastropasqua, L Agnifili, E Campos, C Gizzi, G Giannaccare, V Pucci, M Cassamali, C Costagliola, C Traverso, R Scotto, M Musolino, L Landi, A Bagnis, Riva, Ivano, Legramandi, Lorenzo, Katsanos, Andrea, Oddone, Francesco, Rulli, Eliana, Roberti, Gloria, Quaranta, Luciano, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.
- Subjects
Male ,medicine.medical_specialty ,Multivariate statistics ,Visual acuity ,Open angle glaucoma ,genetic structures ,Cross-sectional study ,sociodemographic factors ,Visual Acuity ,Glaucoma ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,Settore MED/30 ,Sickness Impact Profile ,Surveys and Questionnaires ,medicine ,Humans ,030212 general & internal medicine ,Intraocular Pressure ,Vision, Ocular ,Aged ,Demography ,business.industry ,Middle Aged ,medicine.disease ,eye diseases ,glaucoma ,quality of life ,Ophthalmology ,Cross-Sectional Studies ,Italy ,sociodemographic factor ,030221 ophthalmology & optometry ,Quality of Life ,Marital status ,Disease characteristics ,Female ,medicine.symptom ,business ,Glaucoma, Open-Angle - Abstract
Purpose: The purpose of this article was to evaluate the potential association between sociodemographic factors with clinical characteristics, vision-related quality of life (QoL), and glaucoma-related symptoms scores in a large cohort of primary open-angle glaucoma patients. Materials and Methods: Multicenter, cross-sectional study involving academic and nonacademic centers. Previously diagnosed primary open-angle glaucoma patients aged >18 years were enrolled. At baseline, information on demographic characteristics, social, medical and ocular history, clinical presentation and treatments was collected. Vision-related QoL was evaluated by means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), while glaucoma-related symptoms were evaluated using the Glaucoma Symptom Scale (GSS) questionnaire. The associations between sociodemographic factors with clinical characteristics (mean deviation, pattern standard deviation, best-corrected visual acuity), NEI-VFQ-25, and GSS scores were evaluated by means of univariate and multivariate general linear models. Results: A total of 3227 patients were enrolled. Older age and male sex were significantly associated with lower mean deviation (P
- Published
- 2018
10. Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study
- Author
-
Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, Alessandri, C., Serviddio, G., Palange, P., Greco, E., Bruno, G., Averna, M., Giammanco, A., Sposito, P., de Cristofaro, R., Carulli, L., de Gennaro, L., Pellegrini, E., Cominacini, L., Mozzini, C., Pasini, A. F., Sprovieri, M., Spagnuolo, V., Cerqua, G., Cerasola, G., Mulé, G., Barbagallo, M., Lo Sciuto, S., Monteverde, A., Saitta, A., Lo Gullo, A., Malatino, L., Cilia, C., Terranova, V., Pisano, M., Pinto, A., Di Raimondo, D., Tuttolomondo, A., Conigliaro, R., Signorelli, S., de Palma, D., Galderisi, M., Cudemo, G., Galletti, F., Fazio, V., de Luca, N., Meccariello, A., Caputo, D., de Donato, M. T., Iannuzi, A., Bresciani, A., Giunta, R., Utili, R., Iorio, V., Adinolfi, L. E., Sellitto, C., Iuliano, N., Bellis, P., Tirelli, P., Sacerdoti, D., Vanni, D., Iuliano, L., Ciacciarelli, M., Pacelli, A., Palazzuoli, A., Cacciafesta, M., Gueli, N., Lo Iacono, C., Brusco, S., Verrusio, W., Nobili, L., Tarquinio, N., Pellegrini, F., Vincentelli, G. M., Ravallese, F., Santini, C., Letizia, C., Petramala, L., Zinnamosca, L., Minisola, S., Cilli, M., Colangelo, L., Falaschi, P., Martocchia, A., Pastore, F., Bertazzoni, G., Attalla El Halabieh, E., Paradiso, M., Lizzi, E. M., Timmi, S., Battisti, P., Cerci, S., Ciavolella, M., Di Veroli, C., Malci, F., de Ciocchis, A., Abate, D., Castellino, P., Zanoli, L., Fidone, F., Mannarino, E., Pasqualini, L., Oliverio, G., Pende, A., Artom, N., Ricchio, R., Fimognari, F. L., Alletto, M., Messina, S., Sesti, G., Arturi, F., Succurro, E., Fiorentino, T. V., Pedace, E., Scarpino, P. E., Carullo, G., Maio, R., Sciacqua, A., Frugiuele, P., Battaglia, G., Atzori, S., Delitala, G., Angelucci, E., Sestili, S., Traisci, G., de Feudis, L., Di Michele, D., Fava, A., Balsano, C., de Ciantis, P., Desideri, G., Camerota, A., Mezzetti, M., Gresele, P., Vedovati, C., Fierro, T., Puccetti, L., Bertolotti, M., Mussi, C., Boddi, M., Savino, A., Contri, S., Degl’Innocenti, G., Saller, A., Fabris, F., Pesavento, R., Filippi, L., Vedovetto, V., Puato, M., Treleani, M., de Luca, E., de Zaiacomo, F., Giantin, V., Semplicini, A., Minuz, P., Romano, S., Fantin, F., Manica, A., Stockner, I., Pattis, P., Gutmann, B., Catena, C., Colussi, G., Sechi, L. A., Annoni, G., Bruni, A. A., Castagna, A., Spinelli, D., Miceli, E., Padula, D., Schinco, G., Spreafico, S., Secchi, B., Vanoli, M., Casella, G., Pulixi, E. A., Sansone, L., Serra, M. G., Longo, S., Antonaci, S., Belfiore, A., Frualdo, M., Palasciano, G., Ricci, L., Ventrella, F., Bianco, C., Santovito, D., Cipollone, F., Nicolai, S., Salvati, F., Rini, G. B., Scozzari, F., Muiesan, M. L., Salvetti, M., Bazza, A., Picardi, A., Vespasiani-Gentilucci, U., de Vincentis, A., Cosio, P., Terzolo, M., Madaffari, B., Parasporo, B., Fenoglio, L., Bracco, C., Melchio, R., Gentili, T., Salvi, A., Nitti, C., Gabrielli, A., Martino, G. P., Capucci, A., Brambatti, M., Sparagna, A., Tirotta, D., Andreozzi, P., Ettorre, E., Viscogliosi, G., Servello, A., Musumeci, M., Delfino, M., Giorgi, A., Glorioso, N., Melis, G., Marras, G., Matta, M., Sacco, A., Stellitano, E., Scordo, A., Russo, F., Caruso, A. A., Porreca, E., Tana, M., Ferri, C., Cheli, P., Portincasa, P., Muscianisi, G., Giordani, S., Stanghellini, V., Sabbà, C., Mancuso, G., Bartone, M., Calipari, D., Arcidiacono, G., Bellanuova, I., Ferraro, M., Marigliano, G., Cozzolino, D., Lampitella, A., Acri, V., Galasso, D., Mazzei, F., Buratti, A., Galasso, S., Porta, M., Brizzi, M. F., Fattorini, A., Sampietro, F., D’Angelo, A., Manfredini, R., Pala, M., Fabbian, F., Moroni, C., Valente, L., Lopreiato, F., Parente, F., Granata, M., Moia, M., Braham, S., Rossi, M., Pesce, M., Gentile, A., Catozzo, V., Baciarello, G., Cosimati, A., Ageno, W., Rancan, E., Guasti, L., Ciccaglioni, A., Negri, S., Polselli, M., Prisco, D., Marcucci, R., Ferro, D., Perri, L., Cangemi, R., Saliola, M., Del Ben, M., Angelico, F., Baratta, F., Migliacci, R., Porciello, G., Corrao, S., Proietti, M., Raparelli, V., Napoleone, L., Talerico, G., Amoroso, D., Romiti, G. F., Ruscio, E., Toriello, F., Sperduti, N., Todisco, T., Di Tanna, G., Sacchetti, M. L., Puddu, P. E., Farcomeni, A., Anzaldi, M., Bazzini, C., Bianchi, P. I., Boari, B., Buonauro, A., Buttà, C., Buzzetti, E., Calabria, S., Capeci, W., Caradio, F., Carleo, P., Carrabba, M. D., Castorani, L., Cecchetto, L., Cicco, S., Cimini, C., Colombo, B. M., de Giorgi, A., de Vuono, S., Del Corso, L., Denegri, A., Di Giosia, P., Durante Mangoni, E., Falsetti, L., Forgione, A., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Masala, M., Miceli, G., Montebianco Abenavoli, L., Murgia, G., Naccarato, P., Pattoneri, P., Perego, F., Pesce, P., Piano, S., Pinna, M., Pinto, D., Pretti, V., Pucci, G., Salinaro, F., Salzano, A., Santilli, F., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Tassone, E. J., Torres, D., Vazzana, N., Vecchio, C. R., Vidili, G., Vitale, F., Zaccone, V., ARAPACIS Study Collaborators, Raparelli, V, Pastori, D, Pignataro, S, Vestri, A, Pignatelli, P, Cangemi, R, Proietti, M, Davi, G, Hiatt, W, Lip, G, Corazza, G, Perticone, F, Violi, F, Basili, S, Alessandri, C, Serviddio, G, Palange, P, Greco, E, Bruno, G, Averna, M, Giammanco, A, Sposito, P, Decristofaro, R, Carulli, L, Degennaro, L, Pellegrini, E, Cominacini, L, Mozzini, C, Pasini, A, Sprovieri, M, Spagnuolo, V, Cerqua, G, Cerasola, G, Mule, G, Barbagallo, M, Lo Sciuto, S, Monteverde, A, Saitta, A, Lo Gullo, A, Malatino, L, Cilia, C, Terranova, V, Pisano, M, Pinto, A, Diraimondo, D, Tuttolomondo, A, Conigliaro, R, Signorelli, S, Depalma, D, Galderisi, M, Cudemo, G, Galletti, F, Fazio, V, Deluca, N, Meccariello, A, Caputo, D, Dedonato, M, Iannuzi, A, Bresciani, A, Giunta, R, Utili, R, Iorio, V, Adinolfi, L, Sellitto, C, Iuliano, N, Bellis, P, Tirelli, P, Sacerdoti, D, Vanni, D, Iuliano, L, Ciacciarelli, M, Pacelli, A, Palazzuoli, A, Cacciafesta, M, Gueli, N, Lo Iacono, C, Brusco, S, Verrusio, W, Nobili, L, Tarquinio, N, Pellegrini, F, Vincentelli, G, Ravallese, F, Santini, C, Letizia, C, Petramala, L, Zinnamosca, L, Minisola, S, Cilli, M, Colangelo, L, Falaschi, P, Martocchia, A, Pastore, F, Bertazzoni, G, Attalla El Halabieh, E, Paradiso, M, Lizzi, E, Timmi, S, Battisti, P, Cerci, S, Ciavolella, M, Diveroli, C, Malci, F, Deciocchis, A, Abate, D, Castellino, P, Zanoli, L, Fidone, F, Mannarino, E, Pasqualini, L, Oliverio, G, Pende, A, Artom, N, Ricchio, R, Fimognari, F, Alletto, M, Messina, S, Sesti, G, Arturi, F, Succurro, E, Fiorentino, T, Pedace, E, Scarpino, P, Carullo, G, Maio, R, Sciacqua, A, Frugiuele, P, Battaglia, G, Atzori, S, Delitala, G, Angelucci, E, Sestili, S, Traisci, G, Defeudis, L, Dimichele, D, Fava, A, Balsano, C, Deciantis, P, Desideri, G, Camerota, A, Mezzetti, M, Gresele, P, Vedovati, C, Fierro, T, Puccetti, L, Bertolotti, M, Mussi, C, Boddi, M, Savino, A, Contri, S, Degl'Innocenti, G, Saller, A, Fabris, F, Pesavento, R, Filippi, L, Vedovetto, V, Puato, M, Treleani, M, Deluca, E, Dezaiacomo, F, Giantin, V, Semplicini, A, Minuz, P, Romano, S, Fantin, F, Manica, A, Stockner, I, Pattis, P, Gutmann, B, Catena, C, Colussi, G, Sechi, L, Annoni, G, Bruni, A, Castagna, A, Spinelli, D, Miceli, E, Padula, D, Schinco, G, Spreafico, S, Secchi, B, Vanoli, M, Casella, G, Pulixi, E, Sansone, L, Serra, M, Longo, S, Antonaci, S, Belfiore, A, Frualdo, M, Palasciano, G, Ricci, L, Ventrella, F, Bianco, C, Santovito, D, Cipollone, F, Nicolai, S, Salvati, F, Rini, G, Scozzari, F, Muiesan, M, Salvetti, M, Bazza, A, Picardi, A, Vespasiani-Gentilucci, U, Devincentis, A, Cosio, P, Terzolo, M, Madaffari, B, Parasporo, B, Fenoglio, L, Bracco, C, Melchio, R, Gentili, T, Salvi, A, Nitti, C, Gabrielli, A, Martino, G, Capucci, A, Brambatti, M, Sparagna, A, Tirotta, D, Andreozzi, P, Ettorre, E, Viscogliosi, G, Servello, A, Musumeci, M, Delfino, M, Giorgi, A, Glorioso, N, Melis, G, Marras, G, Matta, M, Sacco, A, Stellitano, E, Scordo, A, Russo, F, Caruso, A, Porreca, E, Tana, M, Ferri, C, Cheli, P, Portincasa, P, Muscianisi, G, Giordani, S, Stanghellini, V, Sabba, C, Mancuso, G, Bartone, M, Calipari, D, Arcidiacono, G, Bellanuova, I, Ferraro, M, Marigliano, G, Cozzolino, D, Lampitella, A, Acri, V, Galasso, D, Mazzei, F, Buratti, A, Galasso, S, Porta, M, Brizzi, M, Fattorini, A, Sampietro, F, D'Angelo, A, Manfredini, R, Pala, M, Fabbian, F, Moroni, C, Valente, L, Lopreiato, F, Parente, F, Granata, M, Moia, M, Braham, S, Rossi, M, Pesce, M, Gentile, A, Catozzo, V, Baciarello, G, Cosimati, A, Ageno, W, Rancan, E, Guasti, L, Ciccaglioni, A, Negri, S, Polselli, M, Prisco, D, Marcucci, R, Ferro, D, Perri, L, Saliola, M, Delben, M, Angelico, F, Baratta, F, Migliacci, R, Porciello, G, Corrao, S, Napoleone, L, Talerico, G, Amoroso, D, Romiti, G, Ruscio, E, Toriello, F, Sperduti, N, Todisco, T, Ditanna, G, Sacchetti, M, Puddu, P, Farcomeni, A, Anzaldi, M, Bazzini, C, Bianchi, P, Boari, B, Buonauro, A, Butta, C, Buzzetti, E, Calabria, S, Capeci, W, Caradio, F, Carleo, P, Carrabba, M, Castorani, L, Cecchetto, L, Cicco, S, Cimini, C, Colombo, B, De Giorgi, A, Devuono, S, Delcorso, L, Denegri, A, Digiosia, P, Durante Mangoni, E, Falsetti, L, Forgione, A, Giorgini, P, Grassi, D, Grembiale, A, Hijazi, D, Iamele, L, Lorusso, G, Marchese, A, Marra, A, Masala, M, Miceli, G, Montebianco Abenavoli, L, Murgia, G, Naccarato, P, Pattoneri, P, Perego, F, Pesce, P, Piano, S, Pinna, M, Pinto, D, Pretti, V, Pucci, G, Salinaro, F, Salzano, A, Santilli, F, Scarpini, F, Scicali, R, Sirico, D, Suppressa, P, Talia, M, Tassone, E, Torres, D, Vazzana, N, Vecchio, C, Vidili, G, Vitale, F, Zaccone, V, Raparelli, V1, Pastori, D1, Pignataro, Sf1, Vestri, Ar2, Pignatelli, P1, Cangemi, R1, Proietti, M3, Davì, G4, Hiatt, Wr5, Lip, Gyh3, Corazza, Gr6, Perticone, F7, Violi, F8, Basili, S1, De Cristofaro, R, De Gennaro, L, Pasini, Af, Mulé, G, Di Raimondo, D, De Palma, D, De Luca, N, De Donato, Mt, Adinolfi, Le, Vincentelli, Gm, Lizzi, Em, Di Veroli, C, De Ciocchis, A, Fimognari, Fl, Fiorentino, Tv, Scarpino, Pe, De Feudis, L, Di Michele, D, De Ciantis, P, De Luca, E, De Zaiacomo, F, Sechi, La, Bruni, Aa, Pulixi, Ea, Serra, Mg, Rini, Gb, Muiesan, Ml, De Vincentis, A, Martino, Gp, Caruso, Aa, Sabbà, C, Brizzi, Mf, Del Ben, M, Romiti, Gf, Di Tanna, G, Sacchetti, Ml, Puddu, Pe, Bianchi, Pi, Buttà, C, Carrabba, Md, Colombo, Bm, De Vuono, S, Del Corso, L, Di Giosia, P, Marra, Am, Tassone, Ej, Vecchio, Cr, Zaccone, V., Pignataro, Sf, Vestri, Ar, Davì, G, Hiatt, Wr, Lip, Gyh, Corazza, Gr, Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, Alessandri C., Serviddio G., Palange P., Greco E., Bruno G., Averna M., Giammanco A., Sposito P., De Cristofaro R., Carulli L., De Gennaro L., Pellegrini E. Cominacini L., Mozzini C., Pasini A.F., Sprovieri M., Spagnuolo V., Cerqua G., Cerasola G., Mulé G., Barbagallo M., Lo Sciuto S., Monteverde A., Saitta A., Lo Gullo A., Malatino L., Cilia C., Terranova V., Pisano M., Pinto A., Di Raimondo D., Tuttolomondo A., Conigliaro R., Signorelli S., De Palma D., Galderisi M., Cudemo G., Galletti F., Fazio V., De Luca N., Meccariello A., Caputo D., De Donato M. T., Iannuzi A., Bresciani A., Giunta R., Utili R., Iorio V., Adinolfi L.E., Sellitto C., Iuliano N., Bellis P., Tirelli P., Sacerdoti D., Vanni D., Iuliano L., Ciacciarelli M., Pacelli A., Palazzuoli A., Cacciafesta M., Gueli N., Lo Iacono C., Brusco S., Verrusio W., Nobili L., Tarquinio N., Pellegrini F., Vincentelli G.M., Ravallese F., Santini C., Letizia C., Petramala L., Zinnamosca L., Minisola S., Cilli M., Colangelo L., Falaschi P., Martocchia A., Pastore F., Bertazzoni G., Attalla El Halabieh E., Paradiso M., Lizzi E.M., Timmi S., Battisti P., Cerci S., Ciavolella M., Di Veroli C., Malci F., De Ciocchis A., Abate D., Castellino P., Zanoli L., Fidone F., Mannarino E., Pasqualini L., Oliverio G., Pende A., Artom N., Ricchio R., Fimognari F.L., Alletto M., Messina S., Sesti G., Arturi F., Succurro E, Fiorentino T.V., Pedace E., Scarpino P.E., Carullo G., Maio R., Sciacqua A., Frugiuele P., Spagnuolo V., Battaglia G., Atzori S., Delitala G., Angelucci E., Sestili S., Traisci G., De Feudis L., Di Michele D., Fava A., Balsano C., De Ciantis P., Desideri G., Camerota A., Mezzetti M., Gresele P., Vedovati C., Fierro T., Puccetti L., Bertolotti M., Mussi C., Boddi M., Savino A., Contri S., Degl’Innocenti G., Saller A., Fabris F., Pesavento R., Filippi L., Vedovetto V., Puato M., Fabris F., Treleani M., De Luca E., De Zaiacomo F., Giantin V., Semplicini A., Minuz P., Romano S., Fantin F., Manica A., Stockner I., Pattis P., Gutmann B., Catena C., Colussi G., Sechi L.A., Annoni G., Bruni A.A., Castagna A., Spinelli D., Miceli E., Padula D., Schinco G., Spreafico S., Secchi B., Vanoli M., Casella G., Pulixi E.A., Sansone L., Serra M.G., Longo S., Antonaci S., Belfiore A., Frualdo M., Palasciano G., Ricci L., Ventrella F., Bianco C., Santovito D., Cipollone F., Nicolai S., Salvati F., Rini G. B., Scozzari F., Muiesan M.L., Salvetti M., Bazza A., Picardi A., Vespasiani-Gentilucci U., De Vincentis A., Cosio P., Terzolo M., Madaffari B., Parasporo B., Fenoglio L., Bracco C., Melchio R., Gentili T., Salvi A., Nitti C., Gabrielli A., Martino G.P., Capucci A., Brambatti M., Sparagna A., Tirotta D., Andreozzi P., Ettorre E., Viscogliosi G., Servello A., Musumeci M., Delfino M., Giorgi A., Glorioso N., Melis G., Marras G., Matta M., Sacco A., Stellitano E., Scordo A., Russo F., Caruso A.A., Porreca E., Tana M., Ferri C., Cheli P., Portincasa P., Muscianisi G., Giordani S., Stanghellini V., Sabbà C., Mancuso G., Bartone M., Calipari D., Arcidiacono G., Bellanuova I., Ferraro M., Marigliano G., Cozzolino D., Lampitella A., Acri V., Galasso D., Mazzei F., Buratti A., Galasso S., Porta M., Brizzi M.F., Fattorini A., Sampietro F., D’Angelo A., Manfredini R., Pala M., Fabbian F., Moroni C., Valente L., Lopreiato F., Parente F., Granata M., Moia M., Braham S., Rossi M., Pesce M., Gentile A., Catozzo V., Baciarello G., Cosimati A., Ageno W., Rancan E., Guasti L., Ciccaglioni A., Negri S., Polselli M., Prisco D., Marcucci R., Ferro D., Perri L., Cangemi R., Saliola M., Del Ben M., Angelico F., Baratta F., Migliacci R., Porciello G., Corrao S. Data entry and Safety Monitoring Board: Proietti M., Raparelli V., Napoleone L., Talerico G., Amoroso D., Romiti G.F., Ruscio E., Toriello F., Sperduti N., Todisco T., Di Tanna G., Sacchetti M.L., Puddu P.E., Farcomeni A. Simi Young Internists Group: Anzaldi M., Bazzini C., Bianchi P.I., Boari B., Bracco C., Buonauro A., Buttà C., Buzzetti E., Calabria S., Capeci W., Caradio F., Carleo P., Carrabba M.D., Castorani L., Cecchetto L., Cicco S., Cimini C., Colombo B.M., De Giorgi A., De Vuono S., Del Corso L., Denegri A., Di Giosia P., Durante Mangoni E., Falsetti L., Forgione A., Giorgini P., Grassi D., Grembiale A., Hijazi D., Iamele L., Lorusso G., Marchese A., Marra A.M., Masala M., Miceli G., Montebianco Abenavoli L., Murgia G., Naccarato P., Padula D., Pattoneri P., Perego F., Pesce P., Piano S., Pinna M., Pinto D., Pretti V., Pucci G., Salinaro F., Salzano A., Santilli F., Scarpini F., Scicali R., Sirico D., Suppressa P., Talia M., Tassone E.J., Torres D., Vazzana N., Vecchio C.R., Vidili G., Vitale F., Zaccone V., Raparelli Valeria, Pastori Daniele, Pignataro Serena Francesca, Vestri Anna Rita, Pignatelli Pasquale, Cangemi Roberto, Proietti Marco, Davì Giovanni, Hiatt William Robert, Lip Gregory Yoke Hong, Corazza Gino Roberto, Perticone Francesco, Violi Francesco, Basili Stefania, Alessandri C, Serviddio G, Palange P, Greco E, Bruno G, Averna M, Giammanco A, Sposito P, De Cristofaro R, Carulli L, De Gennaro L, Pellegrini E, Cominacini L, Mozzini C, Pasini AF, Sprovieri M, Spagnuolo V, Cerqua G, Cerasola G, Mulé G, Barbagallo M, Lo Sciuto S, Monteverde A, Saitta A, Lo Gullo A, Malatino L, Cilia C, Terranova V, Pisano M, Pinto A, Di Raimondo D, Tuttolomondo A, Conigliaro R, Signorelli S, De Palma D, Galderisi M, Cudemo G, Galletti F, Fazio V, De Luca N, Meccariello A, Caputo D, De Donato MT, Iannuzi A, Bresciani A, Giunta R, Utili R, Iorio V, Adinolfi LE, Sellitto C, Iuliano N, Bellis P, Tirelli P, Sacerdoti D, Vanni D, Iuliano L, Ciacciarelli M, Pacelli A, Palazzuoli A, Cacciafesta M, Gueli N, Lo Iacono C, Brusco S, Verrusio W, Nobili L, Tarquinio N, Pellegrini F, Vincentelli GM, Ravallese F, Santini C, Letizia C, Petramala L, Zinnamosca L, Minisola S, Cilli M, Colangelo L, Falaschi P, Martocchia A, Pastore F, Bertazzoni G, Attalla El Halabieh E, Paradiso M, Lizzi EM, Timmi S, Battisti P, Cerci S, Ciavolella M, Di Veroli C, Malci F, De Ciocchis A, Abate D, Castellino P, Zanoli L, Fidone F, Mannarino E, Pasqualini L, Oliverio G, Pende A, Artom N, Ricchio R, Fimognari FL, Alletto M, Messina S, Sesti G, Arturi F, Succurro E, Fiorentino TV, Pedace E, Scarpino PE, Carullo G, Maio R, Sciacqua A, Frugiuele P, Battaglia G, Atzori S, Delitala G, Angelucci E, Sestili S, Traisci G, De Feudis L, Di Michele D, Fava A, Balsano C, De Ciantis P, Desideri G, Camerota A, Mezzetti M, Gresele P, Vedovati C, Fierro T, Puccetti L, Bertolotti M, Mussi C, Boddi M, Savino A, Contri S, Degl’Innocenti G, Saller A, Fabris F, Pesavento R, Filippi L, Vedovetto V, Puato M, Treleani M, De Luca E, De Zaiacomo F, Giantin V, Semplicini A, Minuz P, Romano S, Fantin F, Manica A, Stockner I, Pattis P, Gutmann B, Catena C, Colussi G, Sechi LA, Annoni G, Bruni AA, Castagna A, Spinelli D, Miceli E, Padula D, Schinco G, Spreafico S, Secchi B, Vanoli M, Casella G, Pulixi EA, Sansone L, Serra MG, Longo S, Antonaci S, Belfiore A, Frualdo M, Palasciano G, Ricci L, Ventrella F, Bianco C, Santovito D, Cipollone F, Nicolai S, Salvati F, Rini GB, Scozzari F, Muiesan ML, Salvetti M, Bazza A, Picardi A, Vespasiani-Gentilucci U, De Vincentis A, Cosio P, Terzolo M, Madaffari B, Parasporo B, Fenoglio L, Bracco C, Melchio R, Gentili T, Salvi A, Nitti C, Gabrielli A, Martino GP, Capucci A, Brambatti M, Sparagna A, Tirotta D, Andreozzi P, Ettorre E, Viscogliosi G, Servello A, Musumeci M, Delfino M, Giorgi A, Glorioso N, Melis G, Marras G, Matta M, Sacco A, Stellitano E, Scordo A, Russo F, Caruso AA, Porreca E, Tana M, Ferri C, Cheli P, Portincasa P, Muscianisi G, Giordani S, Stanghellini V, Sabbà C, Mancuso G, Bartone M, Calipari D, Arcidiacono G, Bellanuova I, Ferraro M, Marigliano G, Cozzolino D, Lampitella A, Acri V, Galasso D, Mazzei F, Buratti A, Galasso S, Porta M, Brizzi MF, Fattorini A, Sampietro F, D’Angelo A, Manfredini R, Pala M, Fabbian F, Moroni C, Valente L, Lopreiato F, Parente F, Granata M, Moia M, Braham S, Rossi M, Pesce M, Gentile A, Catozzo V, Baciarello G, Cosimati A, Ageno W, Rancan E, Guasti L, Ciccaglioni A, Negri S, Polselli M, Prisco D, Marcucci R, Ferro D, Perri L, Cangemi R, Saliola M, Del Ben M, Angelico F, Baratta F, Migliacci R, Porciello G, Corrao S, Proietti M, Raparelli V, Napoleone L, Talerico G, Amoroso D, Romiti GF, Ruscio E, Toriello F, Sperduti N, Todisco T, Di Tanna G, Sacchetti ML, Puddu PE, Farcomeni A, Anzaldi M, Bazzini C, Bianchi PI, Boari B, Buonauro A, Buttà C, Buzzetti E, Calabria S, Capeci W, Caradio F, Carleo P, Carrabba MD, Castorani L, Cecchetto L, Cicco S, Cimini C, Colombo BM, De Giorgi A, De Vuono S, Del Corso L, Denegri A, Di Giosia P, Durante Mangoni E, Falsetti L, Forgione A, Giorgini P, Grassi D, Grembiale A, Hijazi D, Iamele L, Lorusso G, Marchese A, Marra AM, Masala M, Miceli G, Montebianco Abenavoli L, Murgia G, Naccarato P, Pattoneri P, Perego F, Pesce P, Piano S, Pinna M, Pinto D, Pretti V, Pucci G, Salinaro F, Salzano A, Santilli F, Scarpini F, Scicali R, Sirico D, Suppressa P, Talia M, Tassone EJ, Torres D, Vazzana N, Vecchio CR, Vidili G, Vitale F, and Zaccone V
- Subjects
Male ,Settore MED/09 - Medicina Interna ,030204 cardiovascular system & hematology ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Risk Factors ,Major cardiovascular event ,Cause of Death ,Risk of mortality ,Prevalence ,Medicine ,030212 general & internal medicine ,Prospective Studies ,Registries ,Prospective cohort study ,Stroke ,Cause of death ,COPD ,Chronic obstructive pulmonary disease ,Incidence ,Hazard ratio ,Atrial fibrillation ,Cardiovascular mortality ,Major cardiovascular events ,Aged ,Atrial Fibrillation ,Cardiovascular Diseases ,Endpoint Determination ,Female ,Follow-Up Studies ,Humans ,Italy ,Predictive Value of Tests ,Internal Medicine ,Emergency Medicine ,Atrial fibrillation, Cardiovascular mortality, Chronic obstructive pulmonary disease, Major cardiovascular events ,Cardiology ,Settore SECS-S/01 - Statistica ,medicine.medical_specialty ,Chronic Obstructive ,Socio-culturale ,Pulmonary Disease ,03 medical and health sciences ,Internal medicine ,cardiovascular diseases ,business.industry ,medicine.disease ,business ,Mace - Abstract
Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan–Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20–2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76–4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48–3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.
- Published
- 2018
11. Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography
- Author
-
Vincenzo Pucci, Maria Augusta Raggi, V. Pucci, and M.A. Raggi
- Subjects
Clinical Biochemistry ,Phenylcarbamates ,Antiepileptic drug ,Succinimides ,Lamotrigine ,Biochemistry ,Vigabatrin ,Micellar electrokinetic chromatography ,Analytical Chemistry ,Benzodiazepines ,SAMPLE PRE-TREATMENT ,Electrokinetic phenomena ,medicine ,Biological fluids ,Humans ,PLASMA LEVELS ,Chromatography, Micellar Electrokinetic Capillary ,Chromatography ,Triazines ,Chemistry ,Hydantoins ,Valproic Acid ,ANTIEPILEPTIC DRUGS ,Isoxazoles ,Carbamazepine ,Felbamate ,ELECTROKINETIC CAPILLARY CHROMATOGRAPHY ,Acetazolamide ,BIOLOGICAL FLUIDS ,Ethosuximide ,Propylene Glycols ,Zonisamide ,Barbiturates ,Anticonvulsants ,Levetiracetam ,medicine.drug - Abstract
An overview of the electrokinetic chromatographic methods for the analysis of antiepileptic drug levels in biological samples is presented. In particular, micellar electrokinetic capillary chromatography is a very suitable method for the determination of these drugs, because it allows a rapid, selective, and accurate analysis. In addition to the electrokinetic chromatographic studies on the determination of antiepileptic drugs, some information regarding sample pretreatment will also be reported: this is a critical step when the analysis of biological fluids is concerned. The electrokinetic chromatographic methods for the determination of recent antiepileptic drugs (e.g., lamotrigine, levetiracetam) and classical anticonvulsants (e.g., carbamazepine, phenytoin, ethosuximide, valproic acid) will be discussed in depth, and their pharmacological profiles will be briefly described as well.
- Published
- 2005
12. Advances in Therapeutic Drug Monitoring of Atypical Antipsychotic Drugs
- Author
-
Maria Augusta Raggi, Vincenzo Pucci, Roberto Mandrioli, Cesare Sabbioni, M.A. Raggi, R. Mandrioli, V. Pucci, and C. Sabbioni
- Subjects
medicine.diagnostic_test ,ATYPICAL ANTIPSYCHOTICS ,business.industry ,medicine.drug_class ,Atypical antipsychotic ,THERAPEUTIC DRUG MONITORING ,Bioinformatics ,Therapeutic drug monitoring ,PHARMACOLOGICAL PROFILE ,Drug Discovery ,Molecular Medicine ,Medicine ,business ,PLASMA SAMPLE PRETREATMENT ,ANALYTICAL METHODS - Abstract
The introduction in clinical practice of new antipsychotic drugs neurologically safer and with a broader spectrum of efficacy than "classical" neuroleptics has brought about significant improvement in the therapy of schizophrenic patients. These second-generation antipsychotics, usually called "atypical" antipsychotics, have several therapeutical features in common, such as their effectiveness against the negative symptoms of schizophrenia and the advantage of not causing severe extrapyramidal symptoms and hyperprolactinemia. The therapeutic drug monitoring of patients treated with atypical antipsychotics is, however, still advisable. In many cases it can avoid the onset of side and toxic effects due to high plasma levels of the drug caused by overdose or interactions with other drugs. Furthermore, monitoring can significantly improve the patient's compliance, thus leading to higher treatment efficacy. The pharmacological properties of the most widely used atypical antipsychotics (clozapine, olanzapine, risperidone and quetiapine) will be treated herein with particular attention paid to chemical-clinical correlations. The analytical methods suitable for the therapeutical drug monitoring of these drugs will also be discussed. Other recent atypical agents (ziprasidone, aripiprazole, iloperidone, sertindole and zotepine) will be described as well.
- Published
- 2004
13. Atypical antipsychotics: pharmacokinetics, therapeutic drug monitoring and pharmacological interactions
- Author
-
Cesare Sabbioni, Roberto Mandrioli, Maria Augusta Raggi, Vincenzo Pucci, M.A. Raggi, R. Mandrioli, C. Sabbioni, and V. Pucci
- Subjects
PHARMACOKINETICS ,Dibenzothiazepines ,medicine.medical_treatment ,Chemistry, Pharmaceutical ,THERAPEUTIC DRUG MONITORING ,Pharmacology ,PHARMACOLOGICAL INTERACTIONS ,Biochemistry ,Piperazines ,Iloperidone ,Benzodiazepines ,Quetiapine Fumarate ,Sertindole ,Cytochrome P-450 Enzyme System ,Drug Discovery ,medicine ,Humans ,Ziprasidone ,Drug Interactions ,Antipsychotic ,Clozapine ,ANALYTICAL METHODS ,Clinical Trials as Topic ,Molecular Structure ,ATYPICAL ANTIPSYCHOTICS ,business.industry ,Organic Chemistry ,Risperidone ,Thiazoles ,Zotepine ,Olanzapine ,Schizophrenia ,Molecular Medicine ,Quetiapine ,Aripiprazole ,Drug Monitoring ,business ,medicine.drug ,Antipsychotic Agents - Abstract
The development of new “atypical” antipsychotic agents, which are safer than classical neuroleptics and also active against the negative symptoms and neurocognitive deficits caused by the illness, has produced a significant advancement in the treatment of schizophrenia. The atypical (or “second generation”) antipsychotics have several therapeutical properties in common, however they can significantly differ with regard to clinical potency and side effects. The main features regarding pharmacodynamics, pharmacokinetics and pharmacological interactions of the most important atypical antipsychotics, namely clozapine, olanzapine, quetiapine and risperidone, are treated herein. Several analytical methods available for the therapeutic drug monitoring of these drugs are also presented, as well as the novel formulations, which can notably improve the therapy of schizophrenia. Other very recent atypical agents, such as ziprasidone, aripiprazole, iloperidone, sertindole and zotepine will also be briefly described.
- Published
- 2004
14. High-performance liquid chromatographic determination of levetiracetam in human plasma: comparison of different sample clean-up procedures
- Author
-
Vincenzo Pucci, Roberto Mandrioli, Anna Ferranti, Ernst Kenndler, Francesca Bugamelli, Maria Augusta Raggi, V. Pucci, F. Bugamelli, R. Mandrioli, A. Ferranti, E. Kenndler, and M.A. Raggi
- Subjects
Sample (material) ,Clinical Biochemistry ,Sensitivity and Specificity ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Cartridge ,SAMPLE PRE-TREATMENT ,Drug Discovery ,medicine ,Humans ,Solid phase extraction ,HUMAN PLASMA ,Molecular Biology ,Chromatography, High Pressure Liquid ,Pharmacology ,Chromatography ,LEVETIRACETAM ,Extraction (chemistry) ,Reproducibility of Results ,General Medicine ,Piracetam ,LIQUID CHROMATOGRAPHY ,Clean-up ,chemistry ,Yield (chemistry) ,Anticonvulsants ,Levetiracetam ,Methanol ,medicine.drug - Abstract
An accurate and precise high-performance liquid chromatographic method using diode array detection for the determination of the novel antiepileptic, Levetiracetam, has been developed. Three clean-up procedures for the analysis of Levetiracetam in human plasma were implemented and evaluated, namely solid-phase extraction, deproteinization by addition of organic solvents and formation of insoluble salts. Adenosine was used as the internal standard for all three sample pretreatment procedures. Among the several cartridges used for solid-phase extraction, the hydrophilic–lypophilic balance (Oasis® HLB) phase provides the best extraction yield of Levetiracetam, together with high precision. With the two other clean-up procedures involving plasma deproteinization by addition of methanol or zinc sulphate, lower sensitivity and precision of the assays were obtained. However, they are cheaper and faster when compared with the solid-phase extraction procedure. Copyright © 2003 John Wiley & Sons, Ltd.
- Published
- 2004
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.