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Your search keyword '"V. M. Shmeleva"' showing total 3 results
Start Over Author "V. M. Shmeleva" Topic medicine
3 results on '"V. M. Shmeleva"'

1. Genetic determinants of hereditary thrombophilia in pathogenesis of venous thrombosis

Author

S I Kapustin, M N Blinov, V D Kargin, L I Filanovskaya, N В Saltykova, O E Belyazo, O G Golovina, V M Shmeleva, A M Panshina, and L P Papayan

Subjects
thrombosis of the deep veins, thromboembolism of the pulmonary artery, hereditary throm- bophilia, mutations of the factor fv leiden, prothrombin g20210 -» a, polymorphism c677t in the gene of mthfr, Medicine
Abstract

Aim. To study the role of genetic determinants of hereditary thrombophilia in pathogenesis of various clinical manifestations of venous thrombosis in the citizens of the North-West Region of Russia. Material and methods. Mutations of the genes of factor V (FV Leiden), prothrombin (G20210-A) and polymorphism C677-T in the gene of methylentetrahydrofolate reductase (MTHFR) were detected using polymerase chain reaction (PCR) with a following restriction analysis of PCR product in 183 patients with venous thrombosis (115 with isolated thrombosis of the deep veins and 68 with thromboembolism of the pulmonary artery). Results. It was established that mutation FV Leiden is a significant risk factor of deep vein thrombosis in the legs and postthrombotic disease, but this mutation is weakly associated with pulmonary artery thromboembolism (PAT). An essential PAT risk factor is carriage of the variant prothrombin G20210A. Conclusion. Determination of prothrombotic genotypes is a key factor of treatment efficacy and prevention of life-threatening thromboembolic complications.

Published
2003

2. ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM

Author

S. I. Kapustin, L. P. Papayan, V. D. Kargin, V. M. Shmeleva, A. P. Polyakova, M. N. Blinov, and V. E. Soldatenkov

Subjects
medicine.medical_specialty, business.industry, Immunology, venous thromboembolism, Venous circulation, RC581-607, medicine.disease, pro-inflammatory cytokines, Gastroenterology, Thrombosis, Surgery, polymorphism, Pathogenesis, Polymorphism (computer science), Internal medicine, Hemostasis, medicine.artery, Pulmonary artery, medicine, Retrospective analysis, Immunology and Allergy, Immunologic diseases. Allergy, business, gene, Venous thromboembolism
Abstract

Taking into account interrelations between inflammation and hemostasis, as well as immediate effects of IL-1β, IL-6 and TNFα upon blood coagulation system, one may suggest that their functional variants could determine thrombosis risks both in arterial and venous circulation. The aim of this study was to assess possible role of allelic IL-1β, IL-6 and TNFα variants in pathogenesis of venous thromboembolism (VTE) in young patients. A retrospective analysis was performed for a group of 180 patients with early-onset VTE, and 150 healthy. In a sub-group with deep-vein thrombosis of lower extremities (DWTLE) complicated by pulmonary artery thromboembolia (PAT), we have revealed increased frequencies of IL-6 –174C homozygotes (30.8% vs 13.0%, p = 0.02) and IL-1β –31Т (61.5% vs 40.9%, p = 0.03), when compared with a subgroup of DWTLE. Among patients with “isolated” PAT a tendency for increased IL-1β –31ТТ ratio was found, as compared with DWTLE (53.8% vs 40.9%, р = 0,3), like as with control group (53.8% vs 40.7%, р = 0,3), These differences, however, were statistically insignificant. These data may suggest certain effects of IL-1β and IL-6 gene polymorphisms upon clinical characteristics of venous thromboembolism, rather than upon general VTE risk among young persons.

Published
2014

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