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Objective: Although spinal cord stimulation (SCS) is widely used in the treatment of refractory neuropathic pain, the underlying mechanisms of action are still not fully understood. The theory behind that mechanism is based on a simplified model, the gate control theory. It postulates that stimulation[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Intraventricular meningiomas (IVMs) are a rare subgroup accounting for less than 5% of all intracranial meningiomas. Recent studies showed evidence that IVMs are marked by a distinct chromosomal alteration with a combined loss of chromosome 22q and 1p. Here, we aim to map epigenetic [for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Use of navigation for spinal instrumentation has gained traction in recent years but preoperative trajectory-planning is a time-consuming task. We sought to develop and validate an automated planning tool for lumbosacral pedicle screws using a convolutional neural network (CNN). Methods:[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The management of aggressive meningiomas remains challenging due to limited treatment options beside surgical removal and radiotherapy. High recurrence rates and lack of effective chemotherapies may be reasons for unfavorable prognosis of these patients. Consequently, there is an urgent need[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Despite the overall perception of meningioma as a benign disease, 20-35% of patients experience a clinically aggressive course with debilitating treatment and poor outcome. In contrast to the growing interest in novel therapeutic strategies, the impact on health-related quality of life[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: With roughly 200 cases published world-wide since 1930, combination tumours such as collision tumours and tumour-to-tumour metastases (TTM) pose rare constellations of neoplastic disease with their clinical relevance still being a matter of debate. Methods: Among all patients operated[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Indication and treatment of intracerebral arterio-venous malformations (AVMs) are complex and referring to the current literature in some aspects controversial. Besides conservative observation, widely-accepted treatment options encompass microsurgical resection, embolization, a combination[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Tumour-associated macrophages (TAMs) play an emerging role in tumour progression by creating an immunosuppressive tumour microenvironment. Therefore, we investigated TAM numbers and their activation (M1/2) in primary (p‑) and recurrent (r‑) meningiomas and evaluated their[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Until now, the Pignatti risk score has been used to guide treatment decisions after histological diagnosis of diffuse glioma WHO grade II. However, its prognostic value was derived from a historic cohort of gliomas that has been diagnosed by morphologic rather than molecular criteria. Thus,[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Traumatic spinal cord injury (SCI) remains a devastating event with no neuroprotective treatment currently available. Disruption of the blood-spinal cord barrier (BSCB) with subsequent edema formation and neuroinflammation contributes to the disease’s seriousness. It has been linked[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The effects of Deep Brain Stimulation (DBS) for different psychiatric disorders have been explored in clinical trials. Implantable pulse generator (IPGs) replacements represent the most common type of scheduled follow-up surgeries as stimulation parameters are usually higher compared to movement[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Cancer-derived organoids (CDOs) are novel, complex three-dimensional ex vivo tissue cultures that accurately reflect genotype and phenotype of the original tumor with preserved cellular heterogeneity and structural architecture. They offer a new and exciting platform for studying cancer biology[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Intracranial meningioma WHO grade I is considered a benign disease with long-term disease control after extensive surgery. However, the psychooncological burden of these patients is still poorly defined. Here, we sought to analyse health-related quality of life (QoL) after meningioma resection.[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Odontoid type II fractures are the most common cervical spine injuries in patients over 65 years. The decision for surgical treatment in patients over 90 years of age is still controversially discussed. The aim of this study was to assess early morbidity and mortality and long-term outcome[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Screw accuracy in spinal instrumentation has so far mainly been evaluated from a clinical point of view according to positioning within cortical bone compartments or in relation to nervous structures. In the light of the anticipated advancements of robotic assistance devices for spinal instrumentation[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The discovery of the Isocitrate Dehydrogenase (IDH) mutation in glioma has led to a paradigm shift on how we see glioma biology. While it is clear that IDH mutated (IDHmut) and wildtype (IDHwt) tumors have to be viewed as separate entities, the underlying biological differences are still [for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Post-concussive symptoms are frequent in patients with traumatic brain injury (TBI). While various efforts have been made to develop clinical prediction models for post-concussive syndrome (PCS) in adult TBI, data on this condition in children or adolescents is scarce. We, therefore, aimed[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: WHO grade I intracranial gliomas are usually referred to as benign tumors and complete surgical resection is supposed to improve outcome. Unlike other types of glioma however, WHO°I tumors often affect patients at a younger age and are preferentially located within the posterior fossa[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Clivus chordomas are a rare tumor entity considered as low-grade malignancies. Treatment of choice encompasses radical surgical resection - if possible - followed by radiotherapy. Since the huge variety of tumor extension, different surgical approaches appear rational. Within the last ten[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Endoscopic third ventriculostomy (ETV) has become the method of choice in the treatment of obstructive hydrocephalus. Age and etiology could determine success rates of ETV. The outcome is worse in children, 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Treatment of aggressive meningiomas is still challenging for a couple of reasons, including high rate of recurrence of higher-grade meningiomas, impossible total resection and a lack of effective chemotherapies. To address this urgent need for more successful treatments of aggressive[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Despite the widespread use of external ventricular drainage, revision rates, and associated complications are reported between 10 and 40%. Current available image-guided techniques using stereotaxy, endoscopy, or ultrasound for catheter placements remain time-consuming techniques. We[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Rechargeable neurostimulators for deep brain stimulation have been available since 2008, promising longer battery life and fewer replacement surgeries compared to non-rechargeable systems. Long-term data on how recharging affects movement disorder patients are sparse. This is the first multicenter,[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Functional pituitary adenomas (FPA) represent a special sub-entity among pituitary adenomas which come with characteristic challenges for imaging diagnostics, medical and surgical treatment. Transsphenoidal surgery (TSS) is an established treatment option for FPAs aiming at better hormone[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Recent studies have suggested an impact of the AB0 blood group on thromboembolic and haemorrhagic events following trauma or surgical procedures. However, only limited data are available on the impact of the AB0 blood group in neurosurgical patients. The goal of the present study was to evaluate[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Recent focus of experimental research in traumatic brain injury has been directed towards the role of inflammatory processes. Proinflammatory pathways have become the focus of interest; however, in models of ischemic stroke and spinal cord injury it has been shown that anti-inflammatory pathways,[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Since nationwide data on the epidemiology, treatment characteristics and long-term outcome of severe traumatic brain injury (TBI) in Germany are lacking, neurosurgeons from the German Neurosurgery Society (DGNC) and traumatologists from the German Trauma Society (DGU) joined forces in 2016[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Pituitary tumours may lead to compression of the optic chiasm and visual impairment in patients. Therefore, decompression of the optic chiasm is a major goal of surgical treatment. Automated pupillometry has been used in various clinical settings for assessing the optic system. The aim of[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Traumatic brain injury (TBI) is the leading cause of death and disability in children. It includes a range of different pathologies that differ considerably from adult TBI in regard to pathophysiology, injury patterns, and clinical management. Analyzing and understanding injury patterns of[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Traumatic spinal cord injury (SCI) is a devastating event with limited functional recovery. As a potential treatment approach, neural precursor cell (NPC) transplantation has shown beneficial effects on neuroregeneration. However, survival and differentiation of transplanted NPCs and thus[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Craniopharyngiomas are rare and benign tumors of the sellar and/or the parasellar region. Primary treatment involves surgical resection followed by adjuvant radiotherapy. Despite successful therapy, patients often show neuropsychological deficits and impaired quality of life (Qol). The[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Indication for lumbar discectomy has been the target of repeated critical discussions. Unfortunately, the quality of referral of affected patients to specialized surgeons who advise on surgical treatment thereby often receives little attention. We therefore sought to perform a prospective[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brain tumor with fatal outcome. The INFORM registry offers comprehensive molecular profiling of high-risk tumors in order to identify target alterations for potential precision therapy. We analyzed molecular characteristics[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: In our ageing Western society, the incidence of chronic subdural hematomas (cSDH) is raising while more and more affected patients are on antithrombotic drugs (anticoagulants or antiplatelets). In this study, we reviewed our clinical management of cSDH patients on antithrombotic drugs and[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: PNSTs rarely have their origin from lumbosacral roots or plexus and can occur in the retroperitoneum. The tumours can be asymptomatic until they reach an appreciable size. There are only few studies to this topic available. Aim of this study is to show the relevance of a nerve-sparing resection[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Clivus chordomas are rare and (semi-)malignant tumors that originate from remnants of the chorda dorsalis (Notochordoa). Due to the invasive and extensive growth, treatment remains challenging and is affiliated with poor prognosis. Treatment consists of surgical resection followed by carbon[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Recent series analysing the utility of intraoperative MRI (iMRI) in transsphenoidal pituitary surgery suggest that the rate of complete resections can be significantly increased while the rate of pituitary insufficiency remains unaffected. Since iMRI is time-consuming and costly however, [for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Posttraumatic inflammation after spinal cord injury (SCI) is non-resolving and still present in chronic injury stages. It is thought to play a key role in the pathophysiology of SCI and has been associated with further neurodegeneration and impaired functional recovery. Neural Precursor Cells[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Spreading Depolarizations (SDs) play a central role in cerebrovascular diseases. They produce secondary damage in subarachnoid hemorrhage (SAH), head trauma, intracerebral hemorrhage and ischemic stroke. The vasomotor components of SDs in humans are rarely described. SDs with vasoconstrictor[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Spreading depolarizations (SDs) have been reported in many animal stroke models that arises from the core of the ischemic area and spreads across the penumbra and occurs in chiefly in ischemic stroke patients. Hypothermia is a promising neuroprotective strategy that has been studied in running[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Craniopharyngiomas are rare and benign tumors of the sellar and/or the parasellar region. Primary treatment involves surgical resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and, in particular[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Intraoperative MRI (iMRI) is increasingly used for resection guidance in glioma surgery to increase the extent of resection (EOR). For reasons of time- and cost efficacy however, iMRI is often applied in selected cases only which has limited the identification of its general benefits to date.[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Microvascular decompression (MVD) represents the neurosurgical gold standard for patients with refractory classical trigeminal neuralgia (TN). Although success rates of MVD are high, there is a percentage of patients that relapse or do not profit in spite of typical symptomology or intraoperative[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Meningiomas (MGMs) are the most common primary tumors of the central nervous system. Although aggressive MGMs WHO grade II and III are rare, more effective therapies are urgently needed as reflected by a 5-year-recurrence rate of 50-80% in WHO grade III MGMs despite standard surgical[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Tumors of the pineal region are rare and a heterogeneous group of lesions. Currently there is lack of consensus concerning the optimal treatment of these lesions. Treatment often encompasses multimodal therapy consisting of neurosurgical intervention and oncological therapy. Neurosurgical[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: The beneficial impact of a gross total resection (GTR) on patient outcome in low grade glioma (LGG) surgery has been emphasized in the literature. Since GTR is not always feasible in the vicinity of eloquent areas the aim of this study was to evaluate prognosis according to different levels[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

In spite of great success in research severe traumatic brain injury (TBI) remains the most frequent cause for morbidity and mortality in the age < 45 years. The primary lesion emerges at the moment of trauma. Due to several pathophysiological mechanisms secondary lesions occur that enlarge size of contusions significantly. As a consequence of intracranial bleedings and brain edema intracranial pressure (ICP) increases and threaten the patient. Extent of severity (declared in Glasgow Coma Scale Score [GCS]), expansion and type of bleedings (acute and chronic subdural hemorrhage, epidural bleeding, contusion bleedings and intracerebral hemorrhage) determinate operative and conservative therapy as well as intensive care medicine. A specific feature represents frontobasal lesions that, apart of penetrating injuries, are treated interdisciplinary not before ICP is stable, brain edema declining and coagulation sufficient several days after trauma. A persisting rhinoliquorrhoe cause meningitis up to 85 % within 10 years. Patient with GCS < 8 have to be intubated and controlled ventilated. Basic monitoring does not differ from those of other patients treated at the intensive care ward (sufficient breathing [pO (2), pCO (2)], arterial blood pressure, CBC and coagulation parameters, fluid monitoring and nutrition). Additionally, ICP have to be measured and be treated corresponding to the algorithm of ICP treatment. Complementary, oxygen saturation of brain tissue (ptiO (2)), local cerebral blood flow (r-CBF) and cerebral metabolism (micro dialysis) can be measured. Just the combination of the single monitoring parameters gives evidence of the functional condition of the injured brain and relieved planning and performing of the appropriate therapy.

Objective: With the increased use of oral anticoagulation with vitamin K antagonists, neurosurgeons encounter a growing number of emergency patients requiring rapid reversal of anticoagulant effects. Administration of prothrombin complex concentrates (PCC) is recommended for anticoagulation reversal[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Spreading depolarization (SD) is a wave of mass neuronal and glial cell depolarization. SD is associcated with profound cerebrovascular changes that may have important clinical consequences. Ketamine, a NMDA receptor blocker, has the capacity to modify SD occurrence. However, the studies [for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: During last winter seasons some fatal sport-injuries with severe traumatic brain injury (TBI) prompted major discussions about protective helmet use. Although, ski-helmets reportedly lead to a 60% decrease of risk to incur TBI, little is known about the distribution of helmet users and[for full text, please go to the a.m. URL], 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010