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Objective: Microglia, mono-nuclear cells distributed throughout the CNS, are key immune effector cells of the brain. The complex interactions between microglia and the other cell types in glioma play a crucial role in the development of novel treatments, presumably via the regulation of tumor progression[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Fluorescence-guidance with 5-Aminolevulinic Acid (5-ALA) has been approved for malignant glioma surgery by the European Medicine Agencies (EMA) in Europe and the Food and Drug Administration (FDA) in the USA. Multiple systems have since been developed for visualizing fluorescing Protoporphyrin[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The gold standard for the treatment of classic trigeminal neuralgia (TN) is carbamazepine. However, the efficacy of carbamazepine is compromised by its adverse effects. Furthermore, after long-term follow-up only 22% of participants still find carbamazepine effective. Aim[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Surgical resection is the therapy of choice in head and neck paraganglioma (HNPGL), however associated with significant morbidity depending on tumor size and localization. In cases of progressive residual or recurrent disease, novel and less aggressive therapeutic options are warranted. Somatostatin[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: The BLUE 400 filter system (Carl Zeiss Meditec, Oberkochen, Germany) has provided visualization of 5-ALA-induced fluorescence-guided surgery for more than 20 years. Nevertheless, constraints, e.g. limited background discrimination during hemostasis, obstruct fluency of surgery. A novel filter[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Estimating the risk of recurrence is crucial during postoperative care of meningioma patients. However, risk factors for tumor recurrence or high-grade (grade II/III) histology available from routine preoperative imaging remain elusive. Methods: Characteristics on preoperative magnetic[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Working place of spine surgeons in the operating room (OR) requires permanent standing occupation in a monotone constrained posture. The static load is often aggravated by burden of an X-ray lead gown. Working times in excess of 10 hours are not rare due to economic reasons. The ergonomic[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Glioblastoma is a brain tumor with particular poor prognosis despite maximal multimodal treatment. Given the infiltrative nature of this tumor treatment options to improve local tumor control are urgently needed. Fluorescence-guided resection with 5-aminolevulinic acid (5-ALA) is considered[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: The gold standard for the treatment of classic trigeminal neuralgia (TN) is carbamazepine. However, the efficacy of carbamazepine is compromised by its adverse effects. Aim of this study is to assess the clinical outcome following the surgical treatment of TN and to find potential factors[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Although generally considered benign, recurrences in more than 20% after surgery for grade I meningiomas have been described. Hence, determination of risk factors associated with recurrence is crucial during perioperative care of meningioma patients. Increased microvascular density has[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: The majority of surgeries for spinal meningiomas are performed in geriatric patients with commonly poor neurological and medical condition. However, age-related analyses of preoperative symptoms and functional outcomes are rare. Methods: Clinical, neuropathological and radiological data[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Anterior approaches to the thoracic spine enable corpectomy for different pathologies and vertebral replacement. However, this approach has previously required a thoracotomy incision, which is associated with significant perioperative morbidity, pain, and the potential for compromised ventilation[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Pathological CSF dynamics in the cranio cervical junction are thought to account for pathophysiology in Chiari Type I Malformations. Distinctive flow patterns have been visualized by four dimensional MRI phase contrast flow imaging. However, it remains unclear how these recognizable patterns[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Spinal cord and brain stem lesions require a judicious approach with an optimized trajectory due to a clustering of functions on their surfaces. Intraoperative mapping helps locate function. To confidently locate such lesions, neuronavigation alone lack the desired accuracy and is of limited[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Indocyanine green (ICG) facilitates the intraoperative visualization of blood vessels and vascular malformations after intravenous injection. ICG fluorescence video-angiography can be used as a tool before and after neurosurgical clipping of aneurysms in order to evaluate cerebral local perfusion[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: The elderly population is poorly studied and constitutes a rapidly expanding surgical demographic. Although neurological deficits could be present, senior citizens are often surgically undertreated because of age and comorbidities. Due to this demographic change, we have to deal increasingly[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: Treatment of patients suffering from non-traumatic subarachnoidal hemorrhage (SAH) remains challenging. Given that inflammation seems to play a key role in the etiology of vasospasms, the concept of suppression of inflammation by glucocorticoids appears promising. However, data undermining[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective Glioblastoma is an orphan disease with a grave prognosis. Despite recent advances in the therapy, median survival is still restricted to about 15 months. Novel therapies in the recurrent situation have so far failed phase III evaluations. Therefore, new treatment concepts are needed. One concept[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: Giant Cell Tumors (GCT) account for 5% of bone tumors, spinal GCT again form 5% of all GCT. Generally considered benign, local aggressiveness and metastatic growth have been described. Because of low prevalence mostly small clinical series have been published on GCT in the cervical[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Objective: To determine predictors of tumor control and side effects of Gamma Knife Surgery (GKS) for Vestibular Schwannomas (VS). Method: Clinical and radiological data of 1177 patients (median age: 50 years) who underwent GKS for primarily diagnosed (N=987, 86%) and recurrent VS [previous[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Objective: Transforming growth factor-beta (TGF-beta) is a multifunctional regulatory cytokine that has pleiotropic functions, regulating cell differentiation, proliferation, angiogenesis and immune function. Furthermore, a large body of evidence suggests that TGF-beta has profound effects on tumour[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Objective: Approximately only a small fraction of low-grade gliomas (LGGs) displays visible PPIX fluorescence during surgery, after 5-ALA administration. We wanted to determine if PPIX positive LGGs differed in prognosis from non-PPIX positive LGGs and whether this was reflected by molecular factors,[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Background: During surgery for intra- or periorbital tumors, we intraoperatively recorded evoked compound muscle action potentials (ECMAPs) from the extraocular and intraocular muscles. Intraoperative cranial computer tomography (iCCT) allows on the one hand resection control during surgery and on the[for full text, please go to the a.m. URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Background: Titanium cages are widely used in the surgical treatment of spinal metastases. In most cases adjuvant radiotherapy is an essential part of treatment. Radiation target volumes are defined from postoperative imaging. However, titanium cages lead to metal-related artifacts in imaging. Large[for full text, please go to the a.m. URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Background: Ankylosing spondylitis (AS) is an autoimmune inflammatory arthritis causing ossifications and rigidity of the spinal column. Patients with AS have a high incidence of spinal fractures, especially in the cervical spine, with a high rate of epidural hematomas. These have hazardous consequences[for full text, please go to the a.m. URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Objective: Diagnosis of primary central nervous system lymphoma (PCNSL) is usually confirmed by brain biopsy and subsequent neuropathological work-up. In contrast to treatment of other brain tumors, efforts at resection are discouraged. 5-aminolevulinic acid-induced fluorescence (5-ALA) has been established[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Fluorescein sodium has generated renewed interest for off-label use in fluorescence-guided resections of malignant gliomas due to potential advantages such as bright fluorescence and the possibility of intravenous application. We sought to simultaneously visualize 5-aminolevulinic acid (5-ALA)[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Cachectic patients with a body mass index (BMI) of less than 17 (mild to severe underweight) because of individual constitution, chronic inflammatoric desease, HIV or malignant tumor history are more sensitive for complications after dorsal instrumentation concerning woundhealing and postoperative[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Telomerase activation and expression are considered one of the key features in tumorigenesis. Currently, methylations and hotspot mutations of the promoter of the catalytic subunit of the Telomerase (hTERT, human Telomerase Reverse Transcriptase) are discussed as main potential underlying[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Einleitung: Kachektische Patienten mit einem Body Mass Index (BMI) von weniger als 17 (mittleres bis starkes Untergewicht) aufgrund der individuellen Konstitution, chronisch entzündlicher Erkrankung, HIV oder Tumorvorgeschichte sind empfänglicher für Komplikationen nach dorsaler Instrumentierung[for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Objective: Not only are regulatory T cells (Tregs) an essential component of the immune system in maintaining immunologic self-tolerance by suppressing expansion of immune cells but they are also involved in the suppression of anti-tumour immune responses. The transcription factor forkhead box P3 (FOXP3)[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Cerebral aneurysms (IAs) affect 2-5% of the population and familial predisposition plays a significant role in IA pathogenesis. Several lines of evidence suggesting that genetic variations in different genes of matrix metalloproteinases (MMPs) are involved in the etiopathology of IAs.[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Einleitung: Die mechanische Irritation des Iliosakralgelenks ist eine seltene oder vielleicht verkannte Komplikation nach einer dorsalen lumbosakralen Instrumentation und wurde in der Literatur mit 1 Fall beschrieben1. Wir berichten über eine 50-jährige Patientin mit Affektion des rechten [for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Einleitung: Eine ausreichende Visualisierung des Operationsfeldes ist für den Erfolg einer spinalen Operation ausschlaggebend. Neben der Wahl der Vergrößerungshilfe spielt die Ausleuchtung eine entscheidende Rolle. Insbesondere bei der Minimalisierung der Zugänge und zunehmender [for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Introduction: Patients with Gorham-Stout disease (GSD), a rare disease of poorly understood etiopathophysiology, suffer from progressive osteolysis. Destruction of bone matrix is caused by lymphatic vessels, which can lead to CSF leakage if parts of bony structures adjacent to CSF spaces are involved.[for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Objective: Eloquent brain has become more and more accessible to surgery. Awake craniotomy with cortical mapping, intraoperative neuromonitoring, functional and diffusion weighted MR-imaging facilitate surgical procedures within or contiguous to Wernicke’s and Broca’s area or the primary[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: To evaluate clinical outcome after surgery for pituitary adenomas with special regard to quality of life. To evaluate factors predicting outcome and risks. Method: Retrospective analysis of a surgical series of 176 patients operated for a pituitary adenoma in a tertiary care center between[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: During surgery for intra- or periorbital tumors, we intraoperatively recorded evoked compound muscle action potentials (ECMAPs) from the extraocular and intraocular muscles. Intraoperative cranial computer tomography (iCCT) allows on the one hand resection control during surgery and on the[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Postoperative wound infections in neurosurgical patients result additional morbidity. In order to reduce the incidence of wound infections the application of a single shot of antibiotics 30 minutes prior to surgery has been established during the last years. Our study aimed at analyzing possible[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: The aim of this study was to assess histological and imaging factors associated with the intraoperative accumulation of 5-aminolaevulinic acid (5-ALA) derived porphyrins in gliomas. Method: Retrospectively, we analyzed the data of patients operated at our department between 01/2012[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Brain tumors are the most frequent solid neoplasms in pediatric patients. Modern therapy concepts including imaging, surgery, radiation, chemo- and immunotherapy improved the prognosis in the past years, yet a gross total resection is still one of the most important survival factors. On the[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Progressive cervical myelopathy sometimes represents a quite challenging condition. Spinal imaging as MRI, myelography and angiography can help to distinguish between degenerative, compressive, nutritive, hypoxic, adhesive or posttraumatic damages, but their informative value is sometimes[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Spreading depression (SD) belongs to the domain of the pathophysiology of the brain and has been linked to various neurological disorders, including migraine with aura, cerebrovascular diseases, head injury, transient global amnesia, and epilepsy. The close kinship between SD and experimental[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Sufficient perfusion is crucial during and after vascular neurosurgical procedures. Thus intraoperative ICG-angiography is a fundamental tool in aneurysm and arterio-venous-malformation surgery. Dynamic ICG fluorescence analysis “flow800”® leads to a better understanding[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Spreading depression (SD) is a pathophysiological condition of the brain. The ECoG correlate of SD is a large slow negative potential change propagating at a rate of ~3 mm/min.The occurrence of SD has been demonstrated in the comatose patients suffering from cerebrovascular diseases.[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Fluorescence-guided surgery with 5-aminolevulinic acid (5-ALA) makes more complete resections of contrast-enhancing tumors in adults possible. 5-ALA elicits synthesis and accumulation of fluorescent porphyrins in various epithelia and cancerous tissues, which can be visualized using a modified[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: Ultrasonic aspiration has been widely adopted in the resection of tumors of the central nervous system. In the past, the tumor tissue fragments obtained have been discarded. To evaluate these fragments as possible sources of material for histopathological study and tissue culture, we compared[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: 5-aminolaevulinic acid (5-ALA) has improved surgical therapy of malignant gliomas. However, there is a lack of knowledge concerning 5-ALA uptake and fluorescence kinetic in different histologies. Aim of this study was to detect differences in malignant gliomas concerning uptake kinetic and[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: Chronic subdural hematoma (cSDH) is common and burr hole trepanation with subsequent inlay of a subdural drainage remains a safe surgical measure. Since performance of scheduled postoperative CT-scans before or after drainage removal is still controversial, we retrospectively analyzed the[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: Chronic subdural hematoma (cSDH) is a frequent disorder in the elderly. Although well investigated, numerous aspects including pathophysiology of clinical symptoms remain unclear. Perfusion deficits are likely to induce the transient neurologic symptoms often seen in cSDH, next to toxic effects[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)