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4 results on '"Spanò R"'

1. Match Analysis, Physical Training, Risk of Injury and Rehabilitation in Padel: Overview of the Literature.

Author

Demeco A, de Sire A, Marotta N, Spanò R, Lippi L, Palumbo A, Iona T, Gramigna V, Palermi S, Leigheb M, Invernizzi M, and Ammendolia A

Subjects
Anthropometry, Exercise, Humans, Risk Factors, Medicine, Sports
Abstract

Padel is a racket sport that has been gaining great popularity and scientific interest in recent years. It could be considered to be a high-intensity intermittent sport with valuable cardiovascular and neuromuscular benefits; however, the risk of injury cannot be neglected. To date, there is still a gap of knowledge in the scientific literature on this emergent sport. Therefore, the present review aims to synthetize the current knowledge on padel game dynamics to better characterize the main risk factors, the injury rate and characteristics, and the most effective rehabilitative treatment strategies. PubMed, Scopus, Cochrane, and PEDro were screened up to January 2022 to identify eligible studies focusing on padel players as participants. Out of 160 records, we included 19 studies, which were focused on match analysis, anthropometric and physical training, the risk of injury, and rehabilitative interventions. The results showed that the high action velocity and the sudden changes in direction during a padel match could represent a risk factor for injuries, especially in untrained players. However, the high heterogeneity of the studies in the literature hinders our ability to draw any strong conclusions, and the results should be carefully considered. Future research should address the lack of knowledge on injury mechanisms and type to implement a tailored rehabilitation program.

Published
2022
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2. X-Ray Phase Contrast Tomography Reveals Early Vascular Alterations and Neuronal Loss in a Multiple Sclerosis Model

Author

V. Grigoryev, Gaetano Campi, Alberto Mittone, Antonio Uccelli, Alessia Cedola, Inna Bukreeva, Nicole Kerlero de Rosbo, Consuelo Venturi, Valentina Petrosino, Lorenzo Massimi, Paola Coan, Francesco Brun, Maddalena Mastrogiacomo, Raffaele Spanò, Alberto Bravin, Alexandra Pacureanu, Michela Fratini, Peter Cloetens, Cedola, A., Bravin, A., Bukreeva, I., Fratini, M., Pacureanu, A., Mittone, A., Massimi, L., Cloetens, P., Coan, P., Campi, G., Spanò, R., Brun, F., Grigoryev, V., Petrosino, V., Venturi, C., Mastrogiacomo, M., Kerlero De Rosbo, Nicole, Uccelli, A., Cedola, A, Bravin, A, Bukreeva, I, Fratini, M, Pacureanu, A, Mittone, A, Massimi, L, Cloetens, P, Coan, P, Campi, G, Spano, R, Brun, F, Grigoryev, V, Petrosino, V, Venturi, C, Mastrogiacomo, M, de Rosbo Nicole, K, Uccelli, A, CNR, Inst Nanotechnol, Rome Unit, Rome, Italy, European Synchrotron Radiation Facility (ESRF), IRCCS Santa Lucia Fdn, Rome, Italy, Ludwig Maximilians Univ Munchen, Dept Phys, Munich, Germany, Ludwig Maximilians Univ Munchen, Fac Med, Munich, Germany, CNR, Inst Crystallog, Rome, Italy, IST Ist Nazl Ric Canc, Policlin San Martino, Genoa, Italy, Univ Genoa, Dept Expt Med, Genoa, Italy, Moscow Engn Phys Inst MEPhI, Moscow, Russia, IST Ist Nazl Ric Canc Genoa, AOU San Martino, Genoa, Italy, Univ Genoa, Dept Neurosci, Rehabil Ophthalmol Genet Maternal & Child Hlth Un, Genoa, Italy, and Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Encephalomyelitis, Autoimmune, Experimental, Science, Encephalomyelitis, [SDV]Life Sciences [q-bio], Central nervous system, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), Disease, Neuropathology, Mesenchymal Stem Cell Transplantation, multiple sclerosis, Article, 03 medical and health sciences, 0302 clinical medicine, Imaging, Three-Dimensional, medicine, Animals, Early Vascular Alteration, Neurons, Multidisciplinary, business.industry, Tomography, X-Ray, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Mesenchymal stem cell, Mesenchymal Stem Cells, medicine.disease, Capillaries, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, FRELON CAMERA, Medicine, Experimental pathology, Nanoparticles, Female, business, X-Ray Phase Contrast Tomography, 030217 neurology & neurosurgery
Abstract

The degenerative effects of multiple sclerosis at the level of the vascular and neuronal networks in the central nervous system are currently the object of intensive investigation. Preclinical studies have demonstrated the efficacy of mesenchymal stem cell (MSC) therapy in experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis, but the neuropathology of specific lesions in EAE and the effects of MSC treatment are under debate. Because conventional imaging techniques entail protocols that alter the tissues, limiting the reliability of the results, we have used non-invasive X-ray phase-contrast tomography to obtain an unprecedented direct 3D characterization of EAE lesions at micro-to-nano scales, with simultaneous imaging of the vascular and neuronal networks. We reveal EAE-mediated alterations down to the capillary network. Our findings shed light on how the disease and MSC treatment affect the tissues, and promote X-ray phase-contrast tomography as a powerful tool for studying neurovascular diseases and monitoring advanced therapies.

Published
2017

3. Characterization of mouse spinal cord vascular network by means of synchrotron radiation X-ray phase contrast tomography

Author

Gaetano Campi, Alberto Bravin, Lorenzo Massimi, Inna Bukreeva, Francesco Brun, Michela Fratini, Alberto Mittone, Antonio Uccelli, Nicole Kerlero de Rosbo, Raffaele Spanò, Milena Mastrogiacomo, Alessia Cedola, Massimi, L, Fratini, M, Bukreeva, I, Brun, F, Mittone, A, Campi, G, Spanò, R, Mastrogiacomo, M, de Rosbo, N, Bravin, A, Uccelli, A, Cedola, A, Massimi, Lorenzo, Fratini, Michela, Bukreeva, Inna, Brun, Francesco, Mittone, Alberto, Campi, Gaetano, Spanò, Raffaele, Mastrogiacomo, Milena, de Rosbo, Nicole Kerlero, Bravin, Alberto, Uccelli, Antonio, and Cedola, Alessia

Subjects
0301 basic medicine, Pathology, Radiology, Nuclear Medicine and Imaging, General Physics and Astronomy, Synchrotron radiation, law.invention, Imaging, Mice, 0302 clinical medicine, law, Nuclear Medicine and Imaging, Contrast (vision), Segmentation, Encephalomyelitis, Tomography, media_common, Experimental autoimmune encephalomyelitis, X-ray, Spinal cord vascular network, General Medicine, Synchrotron, X-Ray Computed, Spinal Cord, Female, X-ray phase contrast tomography, Radiology, medicine.medical_specialty, Materials science, Encephalomyelitis, Autoimmune, Experimental, Vascular segmentation, Animals, Blood Vessels, Imaging, Three-Dimensional, Tomography, X-Ray Computed, Synchrotrons, Biophysics, Physics and Astronomy (all), Blood Vessel, media_common.quotation_subject, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), 03 medical and health sciences, Experimental, medicine, Radiology, Nuclear Medicine and imaging, Animal, Multiple sclerosis, medicine.disease, Encephalomyeliti, 030104 developmental biology, Biophysic, Three-Dimensional, 030217 neurology & neurosurgery, Ex vivo, Biomedical engineering, Autoimmune
Abstract

High resolution Synchrotron-based X-ray Phase Contrast Tomography (XPCT) allows the simultaneous detection of three dimensional neuronal and vascular networks without using contrast agents or invasive casting preparation. We show and discuss the different features observed in reconstructed XPCT volumes of the ex vivo mouse spinal cord in the lumbo-sacral region, including motor neurons and blood vessels. We report the application of an intensity-based segmentation method to detect and quantitatively characterize the modification in the vascular networks in terms of reduction in experimental visibility. In particular, we apply our approach to the case of the experimental autoimmune encephalomyelitis (EAE), i.e. human multiple sclerosis animal model.

Published
2016

4. Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

Author

Giuliana Tromba, Giuseppe Battaglia, Gaetano Campi, Alessia Cedola, Peter Modregger, Alberto Bravin, Domenico Bucci, Raffaele Spanò, Federico Giove, Herwig Requardt, Michela Fratini, Francesco Brun, Maddalena Mastrogiacomo, Inna Bukreeva, Fratini, M, Bukreeva, I, Campi, G, Brun, F, Tromba, G, Modregger, P, Bucci, D, Battaglia, G, Spanò, R, Mastrogiacomo, M, Requardt, H, Giove, F, Bravin, A, Cedola, A, Fdn Santa Lucia, Enrico Fermi Ctr MARBILab, I-00179 Rome, Italy, Univ Rome Tre, Dept Sci, I-00146 Rome, Italy, Univ Roma La Sapienza, CNR, Inst Phys & Chem Proc, Dept Phys, I-00185 Rome, Italy, CNR, Inst Crystallog, I-00016 Monterotondo, Rome, Italy, Elettra Sincrotrone Trieste, Univ Trieste, Dept Engn & Architecture, I-34127 Trieste, Italy, Ecole Polytech Fed Lausanne, Ctr Imagerie BioMed, CH-1015 Lausanne, Switzerland, Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland, IRCCS Neuromed, I-86077 Pozzilli, Italy, AUO San Martino IST Ist Nazl Ric Canc, I-16132 Genoa, Italy, Univ Genoa, Dept Expt Med, I-16132 Genoa, Italy, European Synchrotron Radiation Facility (ESRF), Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy, Fratini, Michela, Bukreeva, Inna, Campi, Gaetano, Brun, Francesco, Tromba, Giuliana, Modregger, Peter, Bucci, Domenico, Battaglia, Giuseppe, Spanò, Raffaele, Mastrogiacomo, Maddalena, Requardt, Herwig, Giove, Federico, Bravin, Alberto, and Cedola, Alessia

Subjects
Pathology, medicine.medical_specialty, Phase-contrast microscopy, imaging, neurodegeneration, spinal cord, [SDV]Life Sciences [q-bio], FOS: Physical sciences, Phase-contrast microscopy, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), Computed tomography, Article, Mice, Simultaneous visualization, Imaging, Three-Dimensional, Mouse Spinal Cord, Neural Pathways, medicine, Animals, Multidisciplinary, medicine.diagnostic_test, business.industry, neurodegeneration, imaging, spinal cord, Spinal cord, Physics - Medical Physics, Corrigenda, 3. Good health, medicine.anatomical_structure, Vascular network, Microvessels, Soma, Neuron, Tomography, Medical Physics (physics.med-ph), Tomography, X-Ray Computed, business, Neuroscience
Abstract

Defaults in vascular (VN) and neuronal networks of spinal cord are responsible for serious neurodegenerative pathologies. Because of inadequate investigation tools, the lacking knowledge of the complete fine structure of VN and neuronal systems is a crucial problem. Conventional 2D imaging yields incomplete spatial coverage leading to possible data misinterpretation, whereas standard 3D computed tomography imaging achieves insufficient resolution and contrast. We show that X-ray high-resolution phase-contrast tomography allows the simultaneous visualization of three-dimensional VN and neuronal systems of mouse spinal cord at scales spanning from millimeters to hundreds of nanometers, with neither contrast agent nor a destructive sample-preparation. We image both the 3D distribution of micro-capillary network and the micrometric nerve fibers, axon-bundles and neuron soma. Our approach is a crucial tool for pre-clinical investigation of neurodegenerative pathologies and spinal-cord-injuries. In particular, it should be an optimal tool to resolve the entangled relationship between VN and neuronal system., Comment: 15 pages, 6 figures

Published
2015

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